D:Premature Ejaculation

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pChart

Disease Term
Synonyms ABNORMAL EJACULATION, Ejaculation Failure, Ejaculation Inhibited, Ejaculatory Behaviour, EJACULATORY DISORDERS, Ejaculatory Dysfunction, Ejaculatory Latency, Ejaculatory Problems, Male Orgasmic Disorder, MALE ORGASMIC DISORDERS, MED PREMATURE EJACULATION
Documents 126
Hot Single Events 20
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Premature Ejaculation. They are ordered first by their relevance to Premature Ejaculation and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT15984 Binding of Avp and Oxt 11 0.32 1.33 3.64 5.00
2 INT341897 Positive_regulation of NT5C3 Positive_regulation of Positive_regulation of Oxt 1 0.32 0.42 1.07 5.00
3 INT341896 Oxt Regulation of Localization of POMC 1 0.07 0.91 0.19 5.00
4 INT198382 Binding of AR and SRD5A1 2 0.06 0.84 0.17 5.00
5 INT341895 Oxt Positive_regulation of Localization of POMC 1 0.08 0.49 0.15 5.00
6 INT341879 Oxt Negative_regulation of Positive_regulation of Hpse 1 0.01 0.83 0.11 5.00
7 INT341880 Oxt Positive_regulation of Ca2 1 0.09 0 0.1 5.00
8 INT341877 Oxtr Regulation of Ca2 1 0.08 0 0.09 5.00
9 INT341882 Positive_regulation of Oxtr Positive_regulation of Positive_regulation of Ptgs2 1 0.02 0.11 0.05 5.00
10 INT293625 Binding of BGLAP and SHBG 1 0.03 0.1 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Premature Ejaculation. They are ordered first by their pain relevance and then by number of times they were reported in Premature Ejaculation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT76336 Negative_regulation of PDE5A 192 0.59 112.02 20.09 100.00
2 INT79598 Regulation of PDE5A 16 0.60 8.68 1.17 98.72
3 INT14132 Negative_regulation of HTR1A 25 0.57 4.93 10.91 98.48
4 INT77855 Gene_expression of Pain1 55 0.75 67.42 54.1 98.16
5 INT3579 Localization of Oxt 555 0.81 43.35 292.44 97.20
6 INT65000 Positive_regulation of Positive_regulation of Htr2c 4 0.67 0.69 2.8 95.28
7 INT18001 Positive_regulation of Htr2c 21 0.67 7.63 11.39 94.88
8 INT103043 Binding of PDE5A 16 0.37 7.79 1.12 94.68
9 INT8785 Gene_expression of ALDH7A1 16 0.75 5.55 1.92 94.40
10 INT246173 Phosphorylation of EEF2 4 0.48 0.44 0.24 93.48
11 INT32515 Negative_regulation of B4GALNT1 82 0.43 28.1 17.46 90.22
12 INT50658 Positive_regulation of HTR2C 5 0.67 2.3 1.9 89.48
13 INT5916 Positive_regulation of HTR1A 51 0.67 18.27 21.38 86.92
14 INT341886 Positive_regulation of EEF2 1 0.11 0.21 0.23 86.64
15 INT158471 Negative_regulation of El1 2 0.37 0.72 0.75 86.40
16 INT48959 Positive_regulation of Positive_regulation of Prkcg 52 0.70 16.47 36.49 85.40
17 INT9131 Positive_regulation of Prkcg 431 0.70 130.8 302.41 84.72
18 INT77309 Positive_regulation of Htr2c 3 0.49 2.72 2.25 83.48
19 INT48912 Localization of NOS1 52 0.77 24.14 10.92 82.56
20 INT185332 Regulation of El2 1 0.36 0.9 0 82.32
21 INT125384 Positive_regulation of Pain1 23 0.49 17.1 14.83 79.84
22 INT2149 Positive_regulation of Oxt 181 0.70 24.8 85.43 79.60
23 INT97984 Negative_regulation of SLC6A4 45 0.59 15.43 18.09 76.56
24 INT53929 Positive_regulation of GNPTAB 12 0.32 6.66 1.4 76.32
25 INT185331 Regulation of El1 1 0.44 0.45 0 75.40
26 INT719 Negative_regulation of SGCG 96 0.57 47.91 30.22 75.00
27 INT95207 Negative_regulation of Pde5a 46 0.58 32.01 10.14 75.00
28 INT94028 Regulation of Twist1 37 0.44 22.41 5.33 75.00
29 INT9358 Positive_regulation of HTR1B 26 0.67 11 17.51 72.40
30 INT169348 Gene_expression of SCLY 8 0.11 6.49 1.33 70.48
31 INT5533 Binding of Oxt 43 0.48 8.69 18.35 60.56
32 INT95585 Negative_regulation of Pde12 18 0.43 8.32 11.23 58.64
33 INT188844 Gene_expression of AES 44 0.58 33.94 5.85 50.00
34 INT200442 Positive_regulation of Gene_expression of AES 5 0.42 5.12 0.48 50.00
35 INT130372 Transcription of PDE5A 7 0.72 1.93 0.4 37.52
36 INT6302 Binding of IFNA1 196 0.48 133.85 32.73 34.72
37 INT443 Localization of POMC 1020 0.81 284.52 443.17 5.00
38 INT477 Localization of Avp 813 0.81 131.58 300.4 5.00
39 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 5.00
40 INT2451 Positive_regulation of Avp 355 0.70 102.66 147.69 5.00
41 INT1033 Positive_regulation of Ca2 507 0.68 131.76 147.64 5.00
42 INT1273 Gene_expression of Avp 356 0.78 90.56 138.7 5.00
43 INT6128 Positive_regulation of Localization of POMC 256 0.70 68.77 121.64 5.00
44 INT4207 Regulation of Avp 267 0.62 63.72 115.33 5.00
45 INT4822 Localization of Ca2 417 0.80 99.57 96.45 5.00
46 INT48767 Negative_regulation of NOS1 312 0.59 154.25 90.32 5.00
47 INT7885 Positive_regulation of Localization of Oxt 160 0.70 14.36 87.7 5.00
48 INT10534 Positive_regulation of Trib3 209 0.60 78.75 81.48 5.00
49 INT4358 Positive_regulation of Localization of Avp 195 0.70 30.79 77.58 5.00
50 INT7886 Regulation of Localization of Avp 146 0.62 14.53 72.99 5.00
51 INT451 Regulation of Oxt 142 0.62 22.07 69.42 5.00
52 INT5941 Gene_expression of Oxt 164 0.76 22.63 65.47 5.00
53 INT13286 Gene_expression of Ca2 317 0.67 71.58 65.01 5.00
54 INT7884 Regulation of Localization of Oxt 102 0.62 7.95 61.71 5.00
55 INT2148 Negative_regulation of Oxt 105 0.59 11.42 57 5.00
56 INT52692 Gene_expression of Ptgs2 160 0.78 85.06 55.73 5.00
57 INT1032 Regulation of Ca2 202 0.52 54.91 53.03 5.00
58 INT1197 Negative_regulation of Localization of POMC 109 0.59 28.29 48.02 5.00
59 INT52690 Positive_regulation of Ptgs2 65 0.68 39.51 30.02 5.00
60 INT17331 Positive_regulation of JUN 132 0.69 60.4 27.03 5.00
61 INT13415 Positive_regulation of Hpse 58 0.70 24.9 25.53 5.00
62 INT47741 Negative_regulation of Flvcr2 43 0.51 5.72 23.37 5.00
63 INT825 Negative_regulation of ADRA1D 54 0.58 20.25 22.78 5.00
64 INT39914 Negative_regulation of Cyp1a2 44 0.58 10.04 22 5.00
65 INT52693 Positive_regulation of Gene_expression of Ptgs2 57 0.70 25.51 21.18 5.00
66 INT3593 Gene_expression of ADRA1D 70 0.75 29.48 20.87 5.00
67 INT14546 Positive_regulation of Localization of Ca2 93 0.67 31.09 18.72 5.00
68 INT12575 Regulation of Hpse 33 0.59 17.7 18.45 5.00
69 INT68347 Negative_regulation of Cyp2d4 34 0.58 7.62 18.35 5.00
70 INT14724 Negative_regulation of CYP19A1 233 0.59 96.56 18.26 5.00
71 INT6782 Gene_expression of SCN5A 156 0.78 33.13 17.88 5.00
72 INT50403 Negative_regulation of CYP2C19 55 0.59 8.97 17.79 5.00
73 INT47742 Binding of Flvcr2 26 0.42 3.28 15.87 5.00
74 INT7523 Regulation of ADRA1D 42 0.45 11.63 14.52 5.00
75 INT113625 Positive_regulation of Gene_expression of Ca2 47 0.50 9.82 14.07 5.00
76 INT14572 Binding of INS 205 0.48 175.43 13.38 5.00
77 INT8629 Positive_regulation of COL7A1 72 0.69 40.66 12.09 5.00
78 INT7132 Localization of NPPA 53 0.81 19.79 10.86 5.00
79 INT132036 Negative_regulation of DPP4 126 0.59 63.24 9.51 5.00
80 INT78038 Gene_expression of Oxtr 43 0.78 18.72 9.38 5.00
81 INT23094 Positive_regulation of Positive_regulation of Ca2 29 0.49 6.8 9.35 5.00
82 INT5939 Regulation of Gene_expression of Oxt 27 0.51 2.84 9.1 5.00
83 INT108202 Positive_regulation of PIK3CG 47 0.67 25.83 8.25 5.00
84 INT38563 Negative_regulation of Gene_expression of Oxt 18 0.56 2.51 6.23 5.00
85 INT4144 Gene_expression of SHBG 64 0.68 39.94 6.08 5.00
86 INT69974 Positive_regulation of Oxtr 30 0.70 2.44 5.73 5.00
87 INT17828 Gene_expression of Pla2g1b 18 0.70 6.22 5.58 5.00
88 INT72000 Gene_expression of Gnaq 17 0.75 3.12 5.48 5.00
89 INT23952 Gene_expression of Cyp2d4 18 0.78 4.76 5.31 5.00
90 INT6021 Binding of PRL 18 0.48 12.55 4.3 5.00
91 INT13742 Gene_expression of Son 45 0.58 2.98 4.19 5.00
92 INT180338 Binding of Cyp2d4 12 0.47 6.87 4.09 5.00
93 INT34720 Positive_regulation of SHBG 58 0.69 32.4 3.83 5.00
94 INT16616 Negative_regulation of SRD5A1 44 0.57 34.81 2.96 5.00
95 INT24149 Gene_expression of BPHL 58 0.59 93.54 2.91 5.00
96 INT19539 Positive_regulation of Gene_expression of ADRA1D 10 0.67 9.4 2.9 5.00
97 INT92877 Gene_expression of PDE5A 35 0.76 17.1 2.7 5.00
98 INT6638 Binding of Oxtr 14 0.34 1.52 2.43 5.00
99 INT25121 Negative_regulation of Positive_regulation of COL7A1 5 0.24 1.32 2.37 5.00
100 INT12033 Binding of PLOD1 15 0.48 8.04 2.3 5.00
101 INT6521 Negative_regulation of Gene_expression of ADRA1D 4 0.57 3.19 2.14 5.00
102 INT110925 Positive_regulation of Positive_regulation of JUN 14 0.49 6.22 1.98 5.00
103 INT112880 Positive_regulation of Gnaq 17 0.49 1.97 1.95 5.00
104 INT15742 Negative_regulation of EPO 37 0.59 17.44 1.84 5.00
105 INT48596 Positive_regulation of NT5C3 3 0.45 0.53 1.79 5.00
106 INT110189 Regulation of Gnaq 3 0.02 0.26 1.63 5.00
107 INT255462 Binding of Avpr1a 8 0.47 2.41 1.61 5.00
108 INT7033 Binding of FSHR 19 0.37 6.66 1.52 5.00
109 INT13740 Positive_regulation of Gene_expression of Son 6 0.52 0.36 1.52 5.00
110 INT17827 Positive_regulation of Gene_expression of Pla2g1b 6 0.61 1.69 1.5 5.00
111 INT33305 Localization of Son 12 0.65 0.88 1.36 5.00
112 INT78034 Localization of Oxtr 7 0.81 1.09 1.36 5.00
113 INT242945 Localization of PDE5A 9 0.75 4.57 1.28 5.00
114 INT198387 Regulation of SRD5A1 2 0.60 1.29 1.26 5.00
115 INT175652 Positive_regulation of BPHL 9 0.44 17.98 1.14 5.00
116 INT78032 Regulation of Oxtr 12 0.62 0.72 1.09 5.00
117 INT98445 Negative_regulation of BPHL 7 0.32 7.24 1.08 5.00
118 INT70505 Positive_regulation of Positive_regulation of Ptgs2 4 0.49 2.22 1.08 5.00
119 INT341885 Positive_regulation of Localization of NT5C3 1 0.49 0.41 1.07 5.00
120 INT231528 Localization of NT5C3 2 0.73 1.78 1.06 5.00
121 INT64044 Localization of DAG1 3 0.59 0.27 0.87 5.00
122 INT200438 Negative_regulation of Gene_expression of SCN5A 6 0.36 1.93 0.71 5.00
123 INT236877 Negative_regulation of Gene_expression of BPHL 12 0.32 16.43 0.56 5.00
124 INT197662 Negative_regulation of Positive_regulation of SHBG 5 0.39 3.54 0.52 5.00
125 INT15569 Negative_regulation of PDE6C 3 0.21 1.24 0.48 5.00
126 INT78037 Positive_regulation of Positive_regulation of Oxtr 4 0.69 0.26 0.46 5.00
127 INT78035 Regulation of Gene_expression of Oxtr 5 0.62 0.26 0.46 5.00
128 INT118610 Localization of BPHL 6 0.57 6.88 0.33 5.00
129 INT102992 Regulation of Negative_regulation of SRD5A1 4 0.60 3.59 0.29 5.00
130 INT97191 Regulation of Gene_expression of Son 3 0.39 0.31 0.27 5.00
131 INT323257 Localization of Itpr1 2 0.23 0.27 0.27 5.00
132 INT173876 Positive_regulation of Positive_regulation of COL7A1 3 0.25 1.57 0.24 5.00
133 INT126794 Binding of SRD5A1 2 0.36 3.26 0.22 5.00
134 INT258250 Positive_regulation of ROCK1 7 0.51 2.07 0.22 5.00
135 INT274016 Negative_regulation of PDE6A 1 0.03 1.27 0.22 5.00
136 INT155668 Negative_regulation of Oxtr 2 0.50 0.28 0.12 5.00
137 INT341884 Positive_regulation of Localization of DAG1 1 0.03 0.21 0.06 5.00
138 INT341887 Positive_regulation of Positive_regulation of ROCK1 1 0.01 0.12 0.05 5.00
139 INT287191 Regulation of Positive_regulation of BPHL 1 0.34 1.18 0.04 5.00
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