D:Premature Ovarian Failure

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Disease Term
Synonyms Gonadotropin Resistant Ovary Syndrome, Gonadotropin Resistant Ovary Syndromes, Ovarian Failures Premature, Ovary Syndrome Gonadotropin Resistant, Ovary Syndrome Resistant, Ovary Syndromes Gonadotropin Resistant, Ovary Syndromes Resistant, Premature Ovarian Failures, RESISTANT OVARY SYNDROME, Resistant Ovary Syndromes
Documents 40
Hot Single Events 19
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Premature Ovarian Failure. They are ordered first by their relevance to Premature Ovarian Failure and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT299460 Foxl2 Positive_regulation of Tpr 1 0.01 0.56 0.05 78.64
2 INT299457 Foxl2 Positive_regulation of Gnrhr 1 0.42 0.56 0.05 77.52
3 INT186240 Binding of AGRP and SCN5A 2 0.13 1.19 0.1 49.12
4 INT350120 FSHR Regulation of CYP19A1 1 0.01 3.02 0 37.96
5 INT350116 FSHR Positive_regulation of Gene_expression of CGA 1 0.01 1.28 0 31.60
6 INT284891 FSHR Positive_regulation of Gene_expression of PLOD1 2 0.03 1.32 0.11 30.76
7 INT350117 GNRHR Negative_regulation of Localization of FSHR 1 0.01 1.06 0 27.04
8 INT350113 GNRHR Negative_regulation of Localization of PLOD1 1 0.01 1.06 0 27.04
9 INT350115 GNRH1 Negative_regulation of Localization of PLOD1 1 0.04 0.99 0 25.76
10 INT350122 GNRH1 Negative_regulation of Localization of FSHR 1 0.05 0.99 0 25.76
11 INT350119 Positive_regulation of GNRH1 Positive_regulation of PLOD1 1 0.04 0.86 0.03 22.88
12 INT350114 Positive_regulation of GNRH1 Positive_regulation of FSHR 1 0.05 0.86 0.03 22.88
13 INT45780 GNRH1 Positive_regulation of PLOD1 3 0.07 1.02 0.63 22.48
14 INT54584 GNRH1 Positive_regulation of FSHR 3 0.48 2.02 0.54 22.04
15 INT334918 GNRH1 Positive_regulation of Gene_expression of FSHR 2 0.11 1.27 0.03 22.04
16 INT299438 Foxl2 Negative_regulation of Star 1 0.37 0.16 0 9.68
17 INT299435 Rspo3 Positive_regulation of Wnt2 1 0.06 0.35 0.19 5.00
18 INT251469 INS Negative_regulation of Gene_expression of SHBG 2 0.11 4.11 0.08 5.00
19 INT350121 INS Negative_regulation of Positive_regulation of SHBG 1 0.09 1.48 0.04 5.00
20 INT350118 INS Negative_regulation of SHBG 1 0.09 1.42 0.04 5.00
21 INT299450 Foxl2 Regulation of Ctla4 1 0.24 0.35 0.03 5.00
22 INT299442 Foxl2 Regulation of Transcription of Ctla4 1 0.24 0.35 0.03 5.00
23 INT299461 Foxl2 Regulation of Gnrhr 1 0.24 0.12 0 5.00
24 INT299454 Gene_expression of Foxl2 Positive_regulation of Positive_regulation of Gnrhr 1 0.42 0 0 5.00
25 INT299444 Foxl2 Positive_regulation of Sirt1 1 0.24 0.31 0 5.00
26 INT299458 Gene_expression of Sirt1 Negative_regulation of Foxl2 1 0.25 0.32 0 5.00
27 INT299455 Binding of Mxd1 and Suds3 1 0.01 0.47 0 5.00
28 INT299447 Lhb Positive_regulation of Gene_expression of Odc1 1 0.24 0.3 0 5.00
29 INT299459 Foxl2 Positive_regulation of Cyp19a1 1 0.34 0.07 0 5.00
30 INT284892 AMH Regulation of Localization of FSHR 1 0.01 0.18 0 5.00
31 INT299440 Gtf3a Regulation of Rhox5 1 0.01 0.15 0 5.00
32 INT299464 Binding of Mxd1 and SIDT1 1 0.11 0.31 0 5.00
33 INT299462 Binding of Mxd1 and Sin3a 1 0.08 0.62 0 5.00
34 INT299437 Regulation of Foxl2 Regulation of Gnrhr 1 0.21 0.05 0 5.00
35 INT299443 Gene_expression of Foxl2 Positive_regulation of Tpr 1 0.01 0.05 0 5.00
36 INT327198 DBT Positive_regulation of Gene_expression of ESRRA 1 0.00 0.42 0 5.00
37 INT299451 Foxl2 Negative_regulation of Gene_expression of Sirt1 1 0.25 0.32 0 5.00
38 INT299441 Foxl2 Regulation of Gene_expression of Gnrhr 1 0.24 0 0 5.00
39 INT299463 Binding of Sin3a and SIDT1 1 0.39 0.31 0 5.00
40 INT299445 Lhb Positive_regulation of Gene_expression of Nr4a2 1 0.22 0.13 0 5.00
41 INT299456 Binding of Gabpa and Notch1 1 0.21 0.09 0 5.00
42 INT299452 Foxl2 Positive_regulation of Aaiq4 1 0.01 0.07 0 5.00
43 INT299449 Foxl2 Regulation of Tpr 1 0.00 0.26 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Premature Ovarian Failure. They are ordered first by their pain relevance and then by number of times they were reported in Premature Ovarian Failure. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT34058 Gene_expression of FMR1 5 0.75 5.11 0.26 100.00
2 INT115039 Positive_regulation of FMR1 4 0.49 2.26 0.46 100.00
3 INT170886 Gene_expression of AIRE 2 0.49 4.63 0.19 99.76
4 INT299414 Gene_expression of Foxl2 1 0.74 4.86 0.04 99.58
5 INT299420 Negative_regulation of Gene_expression of Star 1 0.33 6.66 0.5 98.80
6 INT167716 Negative_regulation of Gene_expression of Gnrhr 2 0.35 6.64 0.93 98.80
7 INT158837 Binding of POLG 4 0.37 4.69 0.44 98.00
8 INT299416 Gene_expression of Star 1 0.53 1.72 0.1 97.52
9 INT3933 Positive_regulation of PLOD1 128 0.70 30.76 42.03 97.12
10 INT167717 Gene_expression of Gnrhr 5 0.55 2.49 0.69 95.68
11 INT299425 Binding of Sin3a 2 0.36 0.92 0.04 94.76
12 INT180359 Localization of AIRE 3 0.54 3.94 0.03 91.96
13 INT1579 Gene_expression of PRL 279 0.78 119.2 55.41 88.28
14 INT69867 Gene_expression of Mip 36 0.75 24.54 10.38 87.44
15 INT210590 Positive_regulation of Gene_expression of Mip 10 0.67 8.09 1.68 87.44
16 INT467 Gene_expression of POMC 1048 0.78 332.8 394.16 83.64
17 INT739 Negative_regulation of POMC 358 0.59 102.28 166.77 83.64
18 INT26538 Positive_regulation of FSHR 103 0.69 30.95 15.33 83.28
19 INT17246 Negative_regulation of POLG 16 0.56 9.69 0.79 81.64
20 INT6782 Gene_expression of SCN5A 156 0.78 33.13 17.88 76.96
21 INT200438 Negative_regulation of Gene_expression of SCN5A 6 0.36 1.93 0.71 76.48
22 INT162 Regulation of Prl 794 0.62 165.01 322.24 75.84
23 INT22838 Gene_expression of Fgg 26 0.25 19.9 3.88 61.60
24 INT177548 Regulation of Tpr 9 0.01 3.87 0.26 60.88
25 INT299413 Regulation of Foxl2 1 0.58 2.08 0.04 59.52
26 INT172789 Regulation of Gene_expression of Nos3 15 0.53 16.23 7.86 59.24
27 INT65245 Gene_expression of Nos3 121 0.78 98.14 41.56 57.32
28 INT12095 Negative_regulation of Edn1 26 0.59 12.01 8.79 56.24
29 INT101049 Positive_regulation of CD5 6 0.67 5.71 0.68 56.20
30 INT227759 Gene_expression of Best1 26 0.42 20.36 1.73 52.32
31 INT251827 Regulation of POLG 3 0.59 2.94 0.04 50.32
32 INT2120 Gene_expression of CD79A 159 0.78 111.69 17.16 50.00
33 INT24325 Regulation of SRY 2 0.24 0.89 0.32 50.00
34 INT121678 Gene_expression of SRY 15 0.68 5.61 0.06 50.00
35 INT266161 Regulation of Negative_regulation of POLG 1 0.38 0.56 0 38.40
36 INT335854 Negative_regulation of Localization of Best1 1 0.06 0.33 0 37.72
37 INT211968 Localization of Best1 11 0.40 9.33 0.38 36.80
38 INT227758 Positive_regulation of Localization of Best1 3 0.07 1.95 0 36.80
39 INT284907 Regulation of Transcription of AGRP 1 0.09 1.01 0.28 36.76
40 INT281403 Transcription of AGRP 4 0.47 1.61 0.27 34.80
41 INT299402 Regulation of Regulation of Foxl2 1 0.43 0.21 0 34.28
42 INT2982 Positive_regulation of Gene_expression of CGA 17 0.59 9.08 1.99 32.00
43 INT7972 Positive_regulation of Gene_expression of PLOD1 15 0.42 5.73 1.96 32.00
44 INT2614 Gene_expression of CGA 187 0.78 105.89 24.77 31.60
45 INT6441 Positive_regulation of CRH 98 0.69 57.22 24.12 30.80
46 INT7970 Gene_expression of PLOD1 120 0.71 44.42 15.54 30.76
47 INT22837 Regulation of Fgg 2 0.10 1.87 0.41 27.20
48 INT138715 Gene_expression of POLG 12 0.66 6.97 0.23 26.00
49 INT7395 Localization of GNRH1 399 0.81 62.88 117.68 25.76
50 INT7397 Negative_regulation of Localization of GNRH1 86 0.59 15.45 29.78 25.60
51 INT920 Localization of PLOD1 223 0.81 42.25 78.7 25.12
52 INT5454 Localization of CRH 124 0.79 79.18 41.53 25.00
53 INT912 Localization of FSHR 91 0.79 23.61 15.58 25.00
54 INT62829 Positive_regulation of VCAM1 39 0.70 38.42 9.15 25.00
55 INT5864 Localization of IL36RN 19 0.44 14.5 6.87 25.00
56 INT5455 Negative_regulation of Localization of CRH 16 0.49 7.31 6.41 25.00
57 INT62525 Positive_regulation of SELE 38 0.70 46 5.25 25.00
58 INT82354 Positive_regulation of PECAM1 25 0.34 22.93 4.69 25.00
59 INT5131 Gene_expression of GNRH1 109 0.78 28.79 23.94 23.52
60 INT15609 Positive_regulation of Gene_expression of GNRH1 17 0.49 5.15 3.34 23.52
61 INT4145 Gene_expression of FSHR 124 0.77 44.98 13.04 21.44
62 INT28739 Binding of Ins1 35 0.37 22.43 2.14 21.08
63 INT170855 Negative_regulation of GOPC 188 0.38 70.92 15.41 17.28
64 INT720 Positive_regulation of POMC 807 0.70 237.37 353.83 8.72
65 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 5.00
66 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 5.00
67 INT812 Localization of INS 1026 0.81 515.6 145.31 5.00
68 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 5.00
69 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
70 INT65733 Positive_regulation of Cnr1 125 0.70 40.27 67.33 5.00
71 INT1199 Positive_regulation of INS 579 0.70 399.64 50.43 5.00
72 INT106525 Phosphorylation of Akt1 436 0.82 183.81 47.82 5.00
73 INT5130 Regulation of GNRH1 139 0.62 31.95 42.08 5.00
74 INT101992 Localization of VEGFA 413 0.81 258.23 36.15 5.00
75 INT60710 Gene_expression of Col7a1 217 0.78 113.2 35.2 5.00
76 INT5868 Positive_regulation of GNRH1 122 0.69 20.96 32.8 5.00
77 INT1495 Positive_regulation of Rtcd1 91 0.54 22.93 32.43 5.00
78 INT7975 Regulation of PLOD1 97 0.62 20.9 30.51 5.00
79 INT15610 Localization of GOPC 223 0.65 68.26 28.7 5.00
80 INT1638 Negative_regulation of PLOD1 92 0.59 21.69 26.61 5.00
81 INT2261 Gene_expression of Lhb 121 0.77 42.78 26.04 5.00
82 INT67610 Positive_regulation of Pparg 53 0.70 31.91 25.2 5.00
83 INT3589 Positive_regulation of SCN5A 101 0.57 46.01 21.73 5.00
84 INT1644 Regulation of FSHR 77 0.55 15.62 21.49 5.00
85 INT1792 Positive_regulation of CGA 123 0.70 64.73 20.79 5.00
86 INT3060 Negative_regulation of Bche 94 0.59 46.75 18.51 5.00
87 INT56749 Gene_expression of PCNA 219 0.77 111.25 18.42 5.00
88 INT14724 Negative_regulation of CYP19A1 233 0.59 96.56 18.26 5.00
89 INT27670 Negative_regulation of Ace 122 0.57 79.21 18.08 5.00
90 INT68681 Transcription of VEGFA 132 0.71 80.47 17.03 5.00
91 INT10214 Gene_expression of VIM 153 0.78 115.88 16.29 5.00
92 INT171666 Regulation of GOPC 117 0.39 40.41 15.47 5.00
93 INT81495 Positive_regulation of CNR2 28 0.67 14.62 14.27 5.00
94 INT54763 Binding of Il6 82 0.48 63.27 12.89 5.00
95 INT8210 Positive_regulation of Gene_expression of INS 188 0.68 146.57 12.83 5.00
96 INT2415 Binding of MAOA 26 0.47 13.26 11.86 5.00
97 INT4605 Negative_regulation of Gene_expression of INS 220 0.58 139.66 10.75 5.00
98 INT23676 Gene_expression of Chrna7 47 0.75 23.66 9.51 5.00
99 INT9548 Gene_expression of CHKB 99 0.65 50.86 9.03 5.00
100 INT1647 Negative_regulation of FSHR 54 0.45 13.44 8.87 5.00
101 INT91772 Gene_expression of PSEN1 115 0.75 38.12 8.48 5.00
102 INT111607 Gene_expression of CDH1 103 0.75 90.45 7.77 5.00
103 INT10344 Localization of Jun 23 0.73 6.36 7.46 5.00
104 INT800 Negative_regulation of Grhpr 21 0.42 10.3 7.17 5.00
105 INT22834 Negative_regulation of CYP21A2 28 0.58 23.07 7.13 5.00
106 INT196192 Gene_expression of Mrgpre 21 0.77 14.87 6.53 5.00
107 INT4144 Gene_expression of SHBG 64 0.68 39.94 6.08 5.00
108 INT9683 Binding of GH1 57 0.47 21.14 5.99 5.00
109 INT38556 Gene_expression of DBT 47 0.50 12.52 5.6 5.00
110 INT4613 Positive_regulation of Sirt1 32 0.67 18.19 5.53 5.00
111 INT23598 Binding of SCN5A 32 0.40 16 5.35 5.00
112 INT81796 Binding of AGRP 62 0.36 37.19 5.3 5.00
113 INT75682 Regulation of Chrna7 14 0.45 10.24 5.25 5.00
114 INT924 Regulation of Localization of FSHR 15 0.45 1.4 5.07 5.00
115 INT22825 Regulation of Gtf3a 36 0.25 19.93 5.03 5.00
116 INT12726 Gene_expression of Rtcd1 17 0.32 2.55 4.76 5.00
117 INT8340 Negative_regulation of SHBG 49 0.57 35.96 4.73 5.00
118 INT240934 Gene_expression of Sirt1 24 0.75 18.77 4.68 5.00
119 INT2144 Localization of COL7A1 36 0.74 20.92 4.67 5.00
120 INT32324 Gene_expression of Eda 20 0.75 6.43 4.66 5.00
121 INT6021 Binding of PRL 18 0.48 12.55 4.3 5.00
122 INT141665 Gene_expression of AGRP 83 0.67 43.43 4.24 5.00
123 INT4988 Gene_expression of KRT1 64 0.77 43.4 4.12 5.00
124 INT170738 Binding of Icam1 23 0.37 25.49 4.09 5.00
125 INT11370 Positive_regulation of LHB 15 0.28 5.45 4.01 5.00
126 INT34720 Positive_regulation of SHBG 58 0.69 32.4 3.83 5.00
127 INT28060 Positive_regulation of Hdlcl1 48 0.66 37.31 3.79 5.00
128 INT143998 Binding of IK 11 0.34 2.44 3.42 5.00
129 INT157401 Gene_expression of Ctla4 21 0.65 15.43 3.2 5.00
130 INT69099 Gene_expression of Serpine2 22 0.78 7.89 2.87 5.00
131 INT64734 Positive_regulation of Mpz 17 0.67 6.81 2.55 5.00
132 INT188756 Positive_regulation of AGRP 43 0.60 23.67 2.51 5.00
133 INT145101 Transcription of Nos3 8 0.70 6.04 2.47 5.00
134 INT50723 Positive_regulation of Nr4a2 7 0.53 0.47 2.46 5.00
135 INT211970 Negative_regulation of Best1 49 0.14 37.33 2.32 5.00
136 INT109305 Phosphorylation of Pik3r1 13 0.53 5.69 2.32 5.00
137 INT12033 Binding of PLOD1 15 0.48 8.04 2.3 5.00
138 INT73809 Regulation of Nos3 18 0.45 10.05 2.27 5.00
139 INT103327 Gene_expression of F8 45 0.71 32.5 2.12 5.00
140 INT221409 Regulation of Sirt1 8 0.58 5.53 2.1 5.00
141 INT55810 Negative_regulation of Positive_regulation of Crp 10 0.41 4.95 2.02 5.00
142 INT33496 Positive_regulation of Gene_expression of FSHR 14 0.46 6.05 1.66 5.00
143 INT118674 Gene_expression of Camkk1 3 0.71 1.03 1.61 5.00
144 INT66930 Positive_regulation of Tcirg1 2 0.15 1.18 1.6 5.00
145 INT69125 Gene_expression of Prlr 6 0.78 2 1.58 5.00
146 INT6830 Positive_regulation of Notch1 20 0.55 7.91 1.57 5.00
147 INT7033 Binding of FSHR 19 0.37 6.66 1.52 5.00
148 INT43479 Positive_regulation of Positive_regulation of CGA 9 0.39 4.24 1.46 5.00
149 INT112109 Gene_expression of FIGF 13 0.31 8.31 1.44 5.00
150 INT1641 Positive_regulation of Negative_regulation of FSHR 3 0.41 1.7 1.43 5.00
151 INT109301 Positive_regulation of Phosphorylation of Pik3r1 5 0.42 1.45 1.38 5.00
152 INT151540 Regulation of Fmr1 8 0.59 6.08 1.34 5.00
153 INT1651 Positive_regulation of Negative_regulation of PLOD1 4 0.46 0.49 1.33 5.00
154 INT102200 Gene_expression of Nr4a2 9 0.72 3.69 1.28 5.00
155 INT123413 Positive_regulation of Tpr 7 0.03 1.05 1.25 5.00
156 INT16013 Gene_expression of Rac1 52 0.75 23.79 1.21 5.00
157 INT91872 Gene_expression of RPA1 9 0.77 5.28 1.12 5.00
158 INT93656 Gene_expression of Hephl1 14 0.22 1.45 1.11 5.00
159 INT168397 Gene_expression of Cyp19a1 2 0.06 1.77 1.06 5.00
160 INT98992 Binding of Vcam1 13 0.34 12.97 1.04 5.00
161 INT83479 Gene_expression of KRT18 30 0.65 27.29 1 5.00
162 INT114017 Gene_expression of CD200 10 0.75 2.38 0.88 5.00
163 INT38558 Positive_regulation of DBT 9 0.31 1.59 0.86 5.00
164 INT93899 Negative_regulation of Tcirg1 5 0.14 4.34 0.85 5.00
165 INT246552 Transcription of Fmr1 11 0.72 6.72 0.71 5.00
166 INT70362 Transcription of GH1 9 0.56 2.01 0.69 5.00
167 INT93655 Localization of Hephl1 6 0.26 0.3 0.68 5.00
168 INT39865 Regulation of Positive_regulation of PLOD1 2 0.27 0.71 0.66 5.00
169 INT112649 Negative_regulation of Serpine2 10 0.43 1.41 0.66 5.00
170 INT187712 Negative_regulation of DBT 11 0.19 2.99 0.65 5.00
171 INT159190 Gene_expression of KRT5 31 0.65 26.67 0.56 5.00
172 INT69127 Positive_regulation of Gene_expression of Prlr 2 0.50 0.57 0.54 5.00
173 INT228832 Gene_expression of Mxd1 14 0.25 1.77 0.52 5.00
174 INT236648 Binding of Hrt1 4 0.07 5.07 0.51 5.00
175 INT120924 Regulation of CHRNA7 1 0.24 0.51 0.5 5.00
176 INT43091 Positive_regulation of Negative_regulation of Ace 3 0.30 1.51 0.48 5.00
177 INT7067 Negative_regulation of Gene_expression of SHBG 7 0.41 5.08 0.48 5.00
178 INT127273 Gene_expression of AMH 24 0.78 9.53 0.47 5.00
179 INT145100 Regulation of Transcription of Nos3 4 0.44 2.05 0.46 5.00
180 INT58679 Gene_expression of Odc1 13 0.78 9.55 0.45 5.00
181 INT198884 Gene_expression of Vldlr 13 0.70 2.41 0.44 5.00
182 INT244736 Gene_expression of Bcl11a 3 0.60 0.43 0.37 5.00
183 INT93887 Gene_expression of ESRRA 4 0.40 2.63 0.36 5.00
184 INT187790 Negative_regulation of Gene_expression of Serpine2 2 0.37 1.23 0.33 5.00
185 INT176895 Negative_regulation of EEF1A2 3 0.41 0.85 0.29 5.00
186 INT7977 Regulation of Gene_expression of FSHR 4 0.44 0.79 0.24 5.00
187 INT299421 Localization of Rspo3 1 0.69 0.35 0.19 5.00
188 INT213275 Positive_regulation of Gene_expression of SHBG 6 0.46 4.24 0.19 5.00
189 INT246551 Negative_regulation of Serpinb12 1 0.01 2.57 0.17 5.00
190 INT299419 Transcription of Ctla4 2 0.43 0.71 0.17 5.00
191 INT280465 Negative_regulation of Sin3a 2 0.41 1.07 0.17 5.00
192 INT95417 Regulation of Gnrhr 3 0.48 0 0.16 5.00
193 INT327200 Positive_regulation of Gene_expression of ESRRA 3 0.23 0.94 0.16 5.00
194 INT316238 Localization of Tcirg1 2 0.30 1.98 0.14 5.00
195 INT316240 Regulation of Tcirg1 2 0.16 2.05 0.13 5.00
196 INT250899 Gene_expression of Thbs2 17 0.75 4.97 0.13 5.00
197 INT327770 Binding of Tcirg1 1 0.14 1.65 0.12 5.00
198 INT195744 Gene_expression of XIST 3 0.65 1.61 0.12 5.00
199 INT151342 Positive_regulation of Positive_regulation of FSHR 5 0.20 1.79 0.11 5.00
200 INT299400 Regulation of Bcl11a 1 0.35 0.32 0.11 5.00
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