D:Primary Pulmonary Hypertension

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Disease Term
Synonyms Ayerza Arrilaga Syndrome, Ayerza S Syndrome, Ayerza Syndrome, AYERZAS SYNDROME, Essential Pulmonary Hypertension, HYPERTENSION PULMONARY, Idiopathic Pulmonary Hypertension, PPHT PRIMARY PULMONARY HYPERTENSION, PULMONARY HYPERTENSION, SYNDROME AYERZA, Syndrome Ayerza Arrilaga
Documents 11
Hot Single Events 29
Hot Interactions 4

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Primary Pulmonary Hypertension. They are ordered first by their relevance to Primary Pulmonary Hypertension and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT261609 Binding of PAH and Hypt 1 0.00 1.26 0.28 100.00
2 INT261597 Binding of PAH and COPD 1 0.00 1.08 0.34 100.00
3 INT261605 Il6 Regulation of smc 1 0.02 1.19 0.3 87.20
4 INT261603 Il6 Regulation of Gene_expression of Vcam1 1 0.16 1.74 0.46 80.80
5 INT261608 Il6 Negative_regulation of Gene_expression of TNF 1 0.03 1.27 0.53 65.48
6 INT261607 Il6 Positive_regulation of smc 1 0.03 0.3 0.05 50.00
7 INT261604 Positive_regulation of Il6 Positive_regulation of smc 1 0.03 0.3 0.05 50.00
8 INT261606 Il6 Regulation of Gene_expression of smc 1 0.03 0 0 50.00
9 INT191718 Binding of FLT1 and VEGFA 35 0.50 12.18 0.27 5.00
10 INT281896 KNG1 Regulation of Binding of KNG1 and NOS3 1 0.02 0.17 0.22 5.00
11 INT281901 Binding of KNG1 and NOS3 1 0.05 0.17 0.22 5.00
12 INT281903 BDKRB1 Positive_regulation of KNG1 1 0.03 0.32 0.21 5.00
13 INT350363 Gatm Negative_regulation of NOS1 1 0.00 0.31 0.17 5.00
14 INT281911 Binding of ANG and MAS1 1 0.05 0.39 0.13 5.00
15 INT102885 Binding of ANG and ACE 2 0.17 0.37 0.13 5.00
16 INT281905 Binding of AGTR2 and NOS3 1 0.08 0.37 0.1 5.00
17 INT281912 Binding of AGTR2 and ANG 1 0.13 0.37 0.1 5.00
18 INT281898 Binding of ANG and ACE Positive_regulation of KNG1 1 0.03 0.37 0.1 5.00
19 INT281899 Binding of ANG and NOS3 1 0.12 0.37 0.1 5.00
20 INT281900 Positive_regulation of Binding of AGT and AGTR1 1 0.12 0.16 0.07 5.00
21 INT281909 Binding of AGT and AGTR1 1 0.09 0.16 0.06 5.00
22 INT281906 BDKRB2 Positive_regulation of ANG 1 0.11 0.51 0.05 5.00
23 INT281908 VEGFA Positive_regulation of NOS3 1 0.14 0.14 0 5.00
24 INT281897 VEGFA Regulation of VEGFA Positive_regulation of NOS3 1 0.04 0.09 0 5.00
25 INT206705 Negative_regulation of Binding of FLT1 and VEGFA 3 0.11 1.9 0 5.00
26 INT281902 Binding of AGT and AKR1A1 1 0.01 0.08 0 5.00
27 INT281907 VEGFA Positive_regulation of Gene_expression of PTGIS 1 0.03 0.14 0 5.00
28 INT281910 Binding of REN and AKR1A1 1 0.01 0.08 0 5.00
29 INT281904 ANG Positive_regulation of PTGIS 1 0.04 0 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Primary Pulmonary Hypertension. They are ordered first by their pain relevance and then by number of times they were reported in Primary Pulmonary Hypertension. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT127458 Positive_regulation of PAH 24 0.58 27.25 2.53 100.00
2 INT163969 Positive_regulation of Hypt 6 0.41 6.24 0.49 100.00
3 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 99.88
4 INT9656 Regulation of Gene_expression of Il6 57 0.62 33.3 17.71 99.60
5 INT11939 Negative_regulation of Il6 138 0.59 87.46 41.24 99.36
6 INT18025 Binding of Pah 32 0.45 30.72 7.93 99.28
7 INT8243 Positive_regulation of Il6 451 0.70 358.24 119.28 99.08
8 INT9657 Positive_regulation of Gene_expression of Il6 237 0.70 180.45 63.6 99.04
9 INT19472 Gene_expression of Il1 554 0.76 419.75 175.35 99.02
10 INT32783 Gene_expression of Pah 33 0.60 30.55 6.86 98.20
11 INT11936 Positive_regulation of Positive_regulation of Il6 34 0.50 26.85 10.59 98.16
12 INT174687 Regulation of Positive_regulation of Il6 10 0.61 9.07 2.61 97.72
13 INT9658 Negative_regulation of Gene_expression of Il6 110 0.59 66.29 32.58 97.04
14 INT9655 Regulation of Il6 98 0.62 70.92 31.95 95.96
15 INT54763 Binding of Il6 82 0.48 63.27 12.89 95.48
16 INT19541 Gene_expression of Ptgir 22 0.65 15.42 5.39 90.92
17 INT15516 Gene_expression of Crp 711 0.77 615.33 173.09 90.24
18 INT58288 Positive_regulation of Gene_expression of Crp 83 0.61 82.23 23.7 90.24
19 INT270748 Regulation of Regulation of Pah 1 0.04 1.61 0.04 89.92
20 INT19158 Gene_expression of PAH 35 0.65 35.81 3.88 89.48
21 INT41506 Localization of Ptgir 6 0.64 2.51 1.04 89.00
22 INT29651 Regulation of Pah 11 0.37 9.95 2.79 88.92
23 INT6364 Gene_expression of Edn1 123 0.78 73.76 28.43 88.80
24 INT14740 Gene_expression of TGFB1 272 0.78 168.48 60.18 86.64
25 INT66924 Positive_regulation of Transcription of Il6 18 0.68 11.8 3.53 82.80
26 INT191835 Gene_expression of Airn 10 0.66 4.83 0.9 82.80
27 INT191832 Positive_regulation of Gene_expression of Airn 3 0.42 1.69 0.16 82.80
28 INT175688 Gene_expression of smc 23 0.16 8.72 1.54 80.32
29 INT246445 Positive_regulation of Gene_expression of smc 2 0.10 2.12 0.19 80.32
30 INT261600 Positive_regulation of Gene_expression of Il6ra 7 0.05 6.22 0.84 78.96
31 INT71220 Positive_regulation of Casp1 15 0.38 10.23 5.84 78.24
32 INT73590 Positive_regulation of Positive_regulation of Casp1 2 0.19 1.94 1.28 78.24
33 INT353117 Negative_regulation of Positive_regulation of Casp1 1 0.06 1.25 0 78.24
34 INT72182 Gene_expression of Mcpt1 167 0.75 123.7 52.15 78.00
35 INT160814 Gene_expression of Il6ra 15 0.07 9.61 1.73 77.52
36 INT73670 Gene_expression of Vcam1 128 0.78 123.79 24.96 77.12
37 INT62543 Gene_expression of Icam1 231 0.78 187.58 52.71 76.48
38 INT49985 Transcription of Il6 62 0.72 40.13 20.29 75.00
39 INT60710 Gene_expression of Col7a1 217 0.78 113.2 35.2 72.52
40 INT18143 Gene_expression of Tbxas1 9 0.56 5.89 2.39 72.36
41 INT51803 Negative_regulation of Pde7a 14 0.59 14.98 4.85 71.36
42 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 64.68
43 INT261601 Binding of Emr1 2 0.02 1.34 0.08 63.08
44 INT76336 Negative_regulation of PDE5A 192 0.59 112.02 20.09 60.80
45 INT4259 Positive_regulation of Npr1 262 0.70 49.37 123.11 50.16
46 INT11937 Localization of Il6 228 0.81 139.83 64.39 50.00
47 INT171715 Gene_expression of Sema5b 46 0.31 6.46 7.48 50.00
48 INT163913 Gene_expression of Il11ra1 18 0.69 12.62 5.34 50.00
49 INT110768 Transcription of Mcpt1 12 0.52 7.66 4.71 50.00
50 INT163915 Positive_regulation of Gene_expression of Il11ra1 2 0.41 1.84 1.37 50.00
51 INT17802 Transcription of Edn1 6 0.24 6.31 1.18 50.00
52 INT261599 Transcription of Icam1 6 0.50 4.55 1.07 50.00
53 INT83946 Transcription of Vcam1 2 0.40 3.33 0.95 50.00
54 INT261602 Positive_regulation of Binding of Il6 2 0.50 1.75 0.62 50.00
55 INT169725 Binding of Il6ra 4 0.07 3.99 0.59 50.00
56 INT261598 Positive_regulation of Transcription of Icam1 3 0.24 2.56 0.55 50.00
57 INT130372 Transcription of PDE5A 7 0.72 1.93 0.4 43.92
58 INT22385 Positive_regulation of Ptgir 8 0.41 5.16 0.71 43.20
59 INT11491 Positive_regulation of KNG1 128 0.67 60.41 58.74 12.40
60 INT5200 Gene_expression of Fos 3083 0.78 894.43 1639.02 5.00
61 INT6056 Negative_regulation of Gene_expression of Fos 601 0.59 193.05 386.84 5.00
62 INT49750 Negative_regulation of CPOX 735 0.58 360.06 274.19 5.00
63 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 5.00
64 INT48955 Gene_expression of Nos2 753 0.78 403.87 208.08 5.00
65 INT48953 Positive_regulation of Nos2 486 0.70 239.85 131.87 5.00
66 INT62124 Gene_expression of NOS1 444 0.78 218.08 114.85 5.00
67 INT48593 Positive_regulation of NOS1 420 0.68 226.15 114.71 5.00
68 INT69764 Positive_regulation of Cnr1 126 0.70 67.8 91.49 5.00
69 INT48767 Negative_regulation of NOS1 312 0.59 154.25 90.32 5.00
70 INT74376 Gene_expression of Cnr1 173 0.78 73.43 89.7 5.00
71 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 5.00
72 INT58400 Negative_regulation of Tnf 182 0.59 129.97 71 5.00
73 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 5.00
74 INT8357 Gene_expression of KNG1 153 0.75 77.26 68.66 5.00
75 INT9196 Gene_expression of PTGS1 215 0.77 96.99 60.5 5.00
76 INT50672 Positive_regulation of CPOX 205 0.44 125.93 60.06 5.00
77 INT48952 Negative_regulation of Nos2 204 0.59 101.73 53.15 5.00
78 INT49017 Negative_regulation of Gene_expression of Nos2 169 0.59 80.64 52.67 5.00
79 INT76620 Gene_expression of Cnr2 93 0.78 34.7 50.14 5.00
80 INT375 Positive_regulation of REN 293 0.70 152.46 47.55 5.00
81 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53 5.00
82 INT9094 Gene_expression of COL7A1 277 0.77 143.42 38.73 5.00
83 INT101992 Localization of VEGFA 413 0.81 258.23 36.15 5.00
84 INT390 Positive_regulation of Agt 170 0.70 61.47 36.08 5.00
85 INT1158 Regulation of Agt 106 0.61 29.4 30.29 5.00
86 INT3167 Binding of KNG1 48 0.48 23.26 26.77 5.00
87 INT74377 Regulation of Cnr1 38 0.59 16.93 24.77 5.00
88 INT6726 Positive_regulation of Edn1 118 0.70 65.96 24.07 5.00
89 INT79061 Positive_regulation of NOS2 92 0.65 58.89 23.96 5.00
90 INT3330 Gene_expression of AGT 149 0.76 98.65 22.73 5.00
91 INT3299 Positive_regulation of AGT 126 0.68 79.45 21.91 5.00
92 INT48692 Binding of VEGFA 345 0.48 210.3 21.31 5.00
93 INT6848 Gene_expression of BDKRB2 40 0.75 17.19 20.04 5.00
94 INT83198 Positive_regulation of Nos3 78 0.64 35.69 17.71 5.00
95 INT29555 Positive_regulation of CALM1 58 0.69 14.09 17.37 5.00
96 INT10173 Binding of Tnf 45 0.48 35.6 14.32 5.00
97 INT22276 Gene_expression of TBXA2R 65 0.77 23.22 14.21 5.00
98 INT5806 Regulation of Edn1 63 0.62 23.46 13.88 5.00
99 INT83201 Gene_expression of NOS3 93 0.78 47.16 12.48 5.00
100 INT8629 Positive_regulation of COL7A1 72 0.69 40.66 12.09 5.00
101 INT66718 Positive_regulation of BDKRB2 21 0.64 9.89 11.6 5.00
102 INT14204 Protein_catabolism of KNG1 41 0.96 20.94 11.47 5.00
103 INT661 Gene_expression of REN 100 0.78 48.21 11.36 5.00
104 INT48912 Localization of NOS1 52 0.77 24.14 10.92 5.00
105 INT8065 Binding of AGT 54 0.48 20.54 10.85 5.00
106 INT113317 Regulation of Cnr2 17 0.52 10.27 10.68 5.00
107 INT74272 Localization of CPOX 39 0.63 25.12 10.53 5.00
108 INT29740 Gene_expression of ANG 55 0.78 24.53 9.86 5.00
109 INT18830 Localization of TBXA2R 25 0.81 7.14 9.28 5.00
110 INT35366 Binding of AR 87 0.47 30.52 8.9 5.00
111 INT48908 Transcription of NOS1 27 0.55 13.46 8.39 5.00
112 INT76091 Positive_regulation of NOS3 48 0.61 18.4 7.92 5.00
113 INT103154 Gene_expression of FLT1 138 0.76 58.5 7.41 5.00
114 INT83006 Gene_expression of AGTR1 59 0.75 54.46 7.27 5.00
115 INT34767 Gene_expression of PTGIR 36 0.42 14.79 6.69 5.00
116 INT49468 Negative_regulation of Pah 28 0.55 24.95 6.29 5.00
117 INT77427 Regulation of Negative_regulation of CPOX 17 0.26 10.03 6.15 5.00
118 INT16359 Positive_regulation of Gene_expression of AGT 30 0.49 28.27 6.14 5.00
119 INT64176 Transcription of CPOX 35 0.41 15.1 5.5 5.00
120 INT102891 Positive_regulation of AGTR1 31 0.67 30.57 5.29 5.00
121 INT48277 Regulation of BDKRB2 9 0.59 2.69 5.05 5.00
122 INT127914 Gene_expression of AGTR2 23 0.68 26.87 4.69 5.00
123 INT76581 Regulation of Negative_regulation of NOS1 14 0.45 7.49 4.4 5.00
124 INT34720 Positive_regulation of SHBG 58 0.69 32.4 3.83 5.00
125 INT6956 Gene_expression of PTGIS 29 0.76 12.1 3.8 5.00
126 INT22274 Negative_regulation of Gene_expression of TBXA2R 12 0.58 3.32 3.28 5.00
127 INT48902 Gene_expression of ACE2 22 0.78 17.91 3.24 5.00
128 INT92814 Negative_regulation of NOS3 25 0.51 20.67 3.07 5.00
129 INT92877 Gene_expression of PDE5A 35 0.76 17.1 2.7 5.00
130 INT25121 Negative_regulation of Positive_regulation of COL7A1 5 0.24 1.32 2.37 5.00
131 INT125377 Localization of CYP2B6 5 0.78 0.59 2.23 5.00
132 INT3533 Binding of REN 24 0.37 10.84 2.16 5.00
133 INT281928 Gene_expression of ARG2 3 0.77 63.17 2.14 5.00
134 INT91594 Localization of NOS3 12 0.78 5.39 2.02 5.00
135 INT143127 Positive_regulation of FLT1 44 0.66 21.7 1.92 5.00
136 INT29739 Positive_regulation of ANG 11 0.69 4.37 1.75 5.00
137 INT107923 Regulation of Gene_expression of NOS3 11 0.61 2.73 1.73 5.00
138 INT26451 Gene_expression of KLK1 14 0.75 5.79 1.66 5.00
139 INT119346 Positive_regulation of PTGIR 9 0.58 6.2 1.61 5.00
140 INT68766 Positive_regulation of Transcription of CPOX 10 0.30 4.76 1.49 5.00
141 INT12429 Negative_regulation of Spdya 5 0.20 1.07 1.49 5.00
142 INT182514 Binding of AGTR1 18 0.47 13.35 1.48 5.00
143 INT4336 Negative_regulation of Gene_expression of REN 13 0.58 7.22 1.43 5.00
144 INT251834 Negative_regulation of Gene_expression of ANG 5 0.59 3.95 1.38 5.00
145 INT78658 Localization of PTGIR 6 0.18 2.46 1.33 5.00
146 INT242945 Localization of PDE5A 9 0.75 4.57 1.28 5.00
147 INT31572 Negative_regulation of FLT1 21 0.48 16.49 1.18 5.00
148 INT79598 Regulation of PDE5A 16 0.60 8.68 1.17 5.00
149 INT103043 Binding of PDE5A 16 0.37 7.79 1.12 5.00
150 INT10033 Localization of PTGIS 10 0.69 6.8 1.07 5.00
151 INT166482 Negative_regulation of AKR1A1 5 0.15 2.51 1.07 5.00
152 INT107922 Positive_regulation of Gene_expression of NOS3 17 0.60 9.32 1.04 5.00
153 INT281919 Localization of ACE2 4 0.75 2.69 1.02 5.00
154 INT112717 Negative_regulation of Binding of VEGFA 21 0.56 11.07 0.99 5.00
155 INT107288 Positive_regulation of ACE2 4 0.66 5.48 0.99 5.00
156 INT132667 Regulation of Transcription of NOS1 1 0.30 2.58 0.95 5.00
157 INT109079 Negative_regulation of ANG 4 0.57 2.2 0.8 5.00
158 INT136690 Regulation of Negative_regulation of Tnf 5 0.45 3.58 0.78 5.00
159 INT268231 Regulation of Gene_expression of PTGIR 2 0.05 0.77 0.62 5.00
160 INT7153 Positive_regulation of Regulation of Edn1 2 0.35 1.97 0.57 5.00
161 INT142452 Regulation of Gene_expression of PTGIS 3 0.23 0.72 0.53 5.00
162 INT197662 Negative_regulation of Positive_regulation of SHBG 5 0.39 3.54 0.52 5.00
163 INT143125 Binding of FLT1 48 0.40 13.6 0.51 5.00
164 INT281922 Positive_regulation of Gene_expression of ARG2 2 0.69 10.45 0.5 5.00
165 INT15569 Negative_regulation of PDE6C 3 0.21 1.24 0.48 5.00
166 INT158019 Positive_regulation of Gene_expression of FLT1 20 0.68 9.73 0.44 5.00
167 INT48336 Negative_regulation of ARG2 4 0.58 3.82 0.36 5.00
168 INT121087 Gene_expression of Pde7a 3 0.17 2.69 0.31 5.00
169 INT4636 Positive_regulation of Regulation of Agt 4 0.50 1.3 0.3 5.00
170 INT6955 Positive_regulation of Gene_expression of PTGIS 3 0.36 0.6 0.29 5.00
171 INT281933 Localization of YWHAZ 2 0.09 1.08 0.27 5.00
172 INT185688 Regulation of Localization of TBXA2R 3 0.15 1.09 0.26 5.00
173 INT187828 Negative_regulation of Gene_expression of ACE2 2 0.29 0.54 0.26 5.00
174 INT102890 Localization of ANG 9 0.72 0.41 0.26 5.00
175 INT173876 Positive_regulation of Positive_regulation of COL7A1 3 0.25 1.57 0.24 5.00
176 INT274016 Negative_regulation of PDE6A 1 0.03 1.27 0.22 5.00
177 INT10031 Positive_regulation of PTGIS 2 0.31 0.67 0.12 5.00
178 INT265803 Positive_regulation of Positive_regulation of FLT1 5 0.41 2.85 0.1 5.00
179 INT281931 Transcription of ACE2 2 0.69 0.57 0.07 5.00
180 INT281926 Positive_regulation of Gene_expression of ACE2 2 0.47 1.19 0.04 5.00
181 INT281929 Transcription of PTGIS 1 0.07 0.34 0.03 5.00
182 INT281917 Negative_regulation of Negative_regulation of FLT1 1 0.16 0.08 0 5.00
183 INT281925 Gene_expression of KLK10 1 0.01 0.32 0 5.00
184 INT281920 Negative_regulation of Negative_regulation of AKR1A1 1 0.04 0.08 0 5.00
185 INT353116 Binding of Pde7a 1 0.08 0.59 0 5.00
186 INT281924 Transcription of ANG 1 0.39 0.1 0 5.00
187 INT281916 Negative_regulation of Transcription of ANG 1 0.23 0.1 0 5.00
188 INT281927 Binding of AKR1A1 1 0.03 0.08 0 5.00
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