D:Primitive Neuroectodermal Tumors

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Disease Term
Synonyms Cerebral Primitive Neuroectodermal Tumor, EPENDYMOBLASTOMA, EPENDYMOBLASTOMAS, Medulloepithelioma, Medulloepitheliomas, NEOPLASM PRIMITIVE NEUROEPITHELIAL, Neoplasms Primitive Neuroepithelial, NEUROECTODERMAL TUMOR PRIMITIVE, Neuroepithelial Neoplasm Primitive, NEUROEPITHELIAL NEOPLASMS PRIMITIVE, Neuroepithelial Tumor Primitive
Documents 160
Hot Single Events 69
Hot Interactions 3

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Primitive Neuroectodermal Tumors. They are ordered first by their relevance to Primitive Neuroectodermal Tumors and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT137398 Binding of CD99 and Vim 2 0.02 2.36 0.09 81.44
2 INT137395 Binding of CD99 and S100B 1 0.17 1.04 0.09 81.44
3 INT137394 Binding of DES and CD99 1 0.17 1.04 0.09 81.44
4 INT239559 MSC Regulation of Gene_expression of BDNF 1 0.05 1 0.09 5.00
5 INT203638 Binding of MR1 and GOPC 1 0.04 1.43 0.05 5.00
6 INT181601 Binding of TP53 and WT1 1 0.30 0.9 0.05 5.00
7 INT239560 MSC Regulation of Gene_expression of IFN1@ 1 0.11 0.87 0.04 5.00
8 INT275232 DUOX2 Positive_regulation of ROS1 1 0.10 0.33 0 5.00
9 INT232364 Bgn Negative_regulation of Agxt 1 0.02 0.65 0 5.00
10 INT231519 Binding of PAX7 and POMT1 1 0.02 0.78 0 5.00
11 INT181599 Binding of EWSR1 and WT1 1 0.40 0.29 0 5.00
12 INT231521 Binding of IARS and POMT1 1 0.03 0.72 0 5.00
13 INT231520 Binding of PAX7 and GOPC 1 0.09 0.98 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Primitive Neuroectodermal Tumors. They are ordered first by their pain relevance and then by number of times they were reported in Primitive Neuroectodermal Tumors. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT175770 Binding of Pnet-ps 1 0.00 4.91 0 100.00
2 INT101209 Gene_expression of Wt1 19 0.72 25.77 0.7 99.92
3 INT101208 Positive_regulation of Gene_expression of Wt1 3 0.47 3.08 0.15 99.92
4 INT671 Positive_regulation of Cea 221 0.69 164.5 47.79 99.86
5 INT18672 Gene_expression of Ncam1 54 0.78 36.64 18.79 99.76
6 INT101212 Positive_regulation of Gene_expression of MTUS1 1 0.01 2.31 0.09 99.52
7 INT101213 Gene_expression of MTUS1 2 0.02 2.72 0.09 99.52
8 INT68269 Gene_expression of CD99 49 0.77 47.38 3.86 98.96
9 INT104442 Transcription of ATF1 5 0.06 4.96 0.65 98.96
10 INT137690 Negative_regulation of Gene_expression of Ncam1 3 0.50 3.37 2.18 98.76
11 INT76477 Positive_regulation of CD99 14 0.50 14.77 1.42 98.72
12 INT136395 Positive_regulation of Gene_expression of CD99 2 0.23 3.19 0.3 98.72
13 INT92916 Gene_expression of Acta2 50 0.74 17.52 6.11 98.64
14 INT78877 Gene_expression of EWSR1 10 0.75 11.16 0.97 98.36
15 INT176888 Positive_regulation of MR1 29 0.67 11.68 1.71 98.28
16 INT27651 Gene_expression of S100A12 45 0.76 52.25 10.51 98.16
17 INT4877 Gene_expression of MME 184 0.78 122.82 24.78 98.16
18 INT37722 Gene_expression of NCAM1 103 0.75 81.57 14.18 98.16
19 INT20055 Gene_expression of CRTAC1 19 0.58 15.49 4.73 98.16
20 INT106972 Gene_expression of MAP2 36 0.75 9.72 3.87 98.16
21 INT4960 Positive_regulation of CSF2 285 0.70 256.73 65.73 97.48
22 INT17739 Gene_expression of S100B 226 0.78 132.7 26.4 97.44
23 INT134224 Gene_expression of FLI1 3 0.53 1.79 0.14 97.44
24 INT148121 Gene_expression of KRT8 35 0.65 29.07 1.05 97.36
25 INT134223 Localization of CD99 4 0.73 4.42 0.16 96.88
26 INT90240 Gene_expression of MYOG 19 0.75 10 1.06 96.72
27 INT56955 Binding of MYOG 5 0.27 2.92 0.73 96.72
28 INT179856 Gene_expression of Sdc1 4 0.75 3.88 0.03 96.72
29 INT158696 Regulation of Ewsr1 1 0.40 0.7 0.08 96.48
30 INT158442 Gene_expression of Nkx2-1 21 0.59 8.47 1.99 96.00
31 INT116314 Gene_expression of Myod1 38 0.70 16.6 0.89 95.92
32 INT138898 Gene_expression of Cd99l2 2 0.09 2.15 0.12 95.88
33 INT138899 Positive_regulation of Cd99l2 1 0.07 1.16 0.09 95.88
34 INT181604 Localization of WT1 1 0.63 1.41 0.03 95.76
35 INT17742 Localization of S100B 44 0.80 17.14 4.65 95.60
36 INT25963 Gene_expression of DES 122 0.75 98.81 11.25 95.20
37 INT59784 Binding of DES 22 0.47 19.48 2.27 95.20
38 INT6557 Gene_expression of Eno2 65 0.77 54.42 8.17 94.64
39 INT5841 Gene_expression of Vim 181 0.72 138.54 16.33 94.56
40 INT6810 Gene_expression of ENO2 70 0.78 54.8 8.35 94.56
41 INT15652 Positive_regulation of ENO2 37 0.68 33.39 5.02 94.56
42 INT4991 Positive_regulation of Vim 74 0.69 69.84 8.33 94.56
43 INT11775 Gene_expression of Ema 39 0.65 38.12 2.99 94.32
44 INT155896 Gene_expression of SUFU 1 0.65 1.74 0.14 93.56
45 INT4988 Gene_expression of KRT1 64 0.77 43.4 4.12 92.64
46 INT6868 Gene_expression of GFAP 136 0.78 84.65 22.7 92.32
47 INT23956 Negative_regulation of DES 12 0.42 10.84 1.82 92.08
48 INT272484 Negative_regulation of Myod1 8 0.39 6.77 0.2 92.08
49 INT304773 Negative_regulation of MYOG 1 0.02 2.35 0.07 92.08
50 INT10248 Gene_expression of KRT20 436 0.78 231.96 32.88 91.76
51 INT8224 Gene_expression of CHGA 73 0.75 53.63 12.31 91.60
52 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 91.56
53 INT15264 Gene_expression of TRAFD1 5 0.23 3.56 0.71 91.44
54 INT76479 Binding of CD99 5 0.33 4.66 0.44 90.40
55 INT22301 Positive_regulation of Gene_expression of CSF2 66 0.63 59.49 14.24 89.76
56 INT63349 Gene_expression of PECAM1 199 0.75 166.03 36.76 89.20
57 INT99572 Localization of Kit 13 0.75 5.23 1.95 86.80
58 INT91891 Gene_expression of Kit 268 0.78 158.89 22.67 86.40
59 INT88278 Binding of Kit 33 0.37 24.45 4.13 86.40
60 INT1912 Gene_expression of Calca 1152 0.78 453.25 739.84 85.60
61 INT161321 Localization of Smarcb1 2 0.68 2.05 0.89 83.72
62 INT161322 Localization of PTEN 9 0.73 5.65 0.57 83.32
63 INT49325 Gene_expression of Cd34 102 0.78 82.75 8.97 83.20
64 INT24891 Gene_expression of SYP 55 0.75 45.76 7.53 82.24
65 INT199681 Gene_expression of SERPINA5 13 0.36 15.42 1.25 82.16
66 INT16364 Gene_expression of HLA-DRA 234 0.78 118.81 45.01 81.48
67 INT48518 Gene_expression of ANPEP 51 0.78 22.88 4.18 81.48
68 INT7980 Gene_expression of Fut4 36 0.62 13.37 3.79 81.48
69 INT69029 Gene_expression of PTPRC 127 0.75 74.26 11.57 80.88
70 INT56924 Binding of CRTAC1 3 0.28 2.82 1.03 78.28
71 INT10214 Gene_expression of VIM 153 0.78 115.88 16.29 77.20
72 INT95636 Gene_expression of ACTG2 23 0.44 19.87 1.75 77.20
73 INT104534 Gene_expression of IGKV2-38 1 0.11 1.75 0.09 76.72
74 INT104533 Gene_expression of CENPV 3 0.75 2.13 0.41 75.00
75 INT78879 Positive_regulation of EWSR1 4 0.50 2.97 0.47 75.00
76 INT121280 Gene_expression of Sephs2 1 0.04 0.99 0.07 75.00
77 INT78878 Positive_regulation of Gene_expression of EWSR1 3 0.49 2.52 0.39 75.00
78 INT28084 Positive_regulation of VIM 49 0.67 35.12 5.15 75.00
79 INT99961 Positive_regulation of SYP 13 0.67 15.13 2.79 75.00
80 INT4993 Gene_expression of Lrrc23 13 0.66 11.04 1.99 75.00
81 INT14515 Positive_regulation of Lrrc23 8 0.28 8.51 0.97 75.00
82 INT75311 Gene_expression of Cd79a 5 0.77 5.13 0.58 75.00
83 INT126220 Positive_regulation of CENPV 2 0.49 1.52 0.17 75.00
84 INT143945 Localization of EWSR1 5 0.78 3.39 0.06 75.00
85 INT105761 Binding of GFAP 13 0.36 14.94 2.32 72.20
86 INT82374 Binding of SYP 13 0.36 13.69 0.85 70.92
87 INT44349 Gene_expression of FSIP1 5 0.77 6.56 2.54 69.76
88 INT14301 Binding of CSF2 82 0.48 67.95 8.98 69.44
89 INT48219 Gene_expression of SLC4A1 34 0.75 33.18 2.84 68.88
90 INT23954 Negative_regulation of Mb 24 0.49 11.27 2.55 67.44
91 INT166312 Negative_regulation of Vim 7 0.22 5.9 0.46 64.32
92 INT48960 Gene_expression of SCG2 16 0.68 4.41 4.33 62.24
93 INT203640 Regulation of MR1 7 0.34 3.8 1.26 54.36
94 INT104143 Transcription of EWSR1 7 0.67 8.1 0.42 53.84
95 INT137349 Transcription of Fli1 1 0.10 0.92 0.11 53.68
96 INT88694 Gene_expression of WT1 17 0.75 21.88 0.56 51.28
97 INT4228 Gene_expression of CAT 50 0.75 20.62 7.18 50.00
98 INT22129 Positive_regulation of Gene_expression of CAT 11 0.67 4.23 2.37 50.00
99 INT208919 Regulation of Fli1 2 0.09 0.73 0.11 50.00
100 INT181606 Regulation of EWSR1 3 0.28 0.4 0 50.00
101 INT228692 Negative_regulation of EWSR1 4 0.27 4.73 0.03 42.32
102 INT157382 Gene_expression of Csi 17 0.58 3.93 0.82 41.28
103 INT178830 Negative_regulation of MR1 16 0.50 7.63 0.44 40.40
104 INT287297 Gene_expression of CREB3L2 1 0.49 1.02 0 40.24
105 INT205654 Gene_expression of FUS 9 0.32 11.53 0.16 35.92
106 INT287295 Transcription of FLI1 1 0.38 0.79 0.08 34.76
107 INT232363 Positive_regulation of Gene_expression of Mgmt 8 0.49 6.01 0.28 31.76
108 INT232361 Positive_regulation of Gene_expression of Agxt 3 0.49 0.11 0 31.76
109 INT232362 Gene_expression of Mgmt 10 0.76 8.08 0.41 31.24
110 INT186121 Gene_expression of Agxt 6 0.65 2.77 0.39 30.44
111 INT156794 Gene_expression of CISH 41 0.58 23.09 5.03 20.32
112 INT194322 Positive_regulation of CST7 1 0.32 0.39 0.17 10.04
113 INT66599 Gene_expression of MC4R 16 0.78 12.37 3.12 9.36
114 INT323078 Negative_regulation of Phosphorylation of SERPINA5 1 0.23 1.05 0 9.00
115 INT323079 Phosphorylation of SERPINA5 1 0.44 1.04 0 9.00
116 INT952 Negative_regulation of GHRH 57 0.56 25.3 10.34 7.72
117 INT867 Gene_expression of IFNA1 930 0.78 594.85 168.03 5.00
118 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 5.00
119 INT12339 Localization of IL8 437 0.81 251.87 117.39 5.00
120 INT170025 Gene_expression of Fig4 588 0.67 183.27 113.32 5.00
121 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83 5.00
122 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 5.00
123 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
124 INT75999 Gene_expression of BDNF 344 0.78 114.19 83.12 5.00
125 INT171145 Positive_regulation of Fig4 274 0.59 93.55 69.81 5.00
126 INT170332 Gene_expression of IFN1@ 477 0.75 275.21 69.65 5.00
127 INT8357 Gene_expression of KNG1 153 0.75 77.26 68.66 5.00
128 INT3375 Gene_expression of IGHE 535 0.77 387.47 65.46 5.00
129 INT546 Binding of ALB 311 0.48 85.98 60.14 5.00
130 INT73048 Gene_expression of MMP9 268 0.77 159.75 57.81 5.00
131 INT157666 Positive_regulation of GOPC 335 0.60 120.19 42.75 5.00
132 INT69437 Positive_regulation of ROS1 328 0.58 222.83 40.56 5.00
133 INT3987 Positive_regulation of IGHE 316 0.70 283.2 40.16 5.00
134 INT74563 Positive_regulation of Gene_expression of ROS1 258 0.61 168.18 34.08 5.00
135 INT234 Binding of Alb 151 0.48 52.34 32.97 5.00
136 INT73498 Gene_expression of IL13 117 0.44 83.85 32.26 5.00
137 INT88318 Gene_expression of CXCR4 208 0.77 189.67 31.72 5.00
138 INT28361 Gene_expression of TP53 443 0.78 384.86 28.8 5.00
139 INT15610 Localization of GOPC 223 0.65 68.26 28.7 5.00
140 INT11159 Gene_expression of EGFR 698 0.78 548.93 25.69 5.00
141 INT58192 Positive_regulation of MRI1 86 0.61 53.81 24.68 5.00
142 INT105021 Binding of GOPC 187 0.40 60.39 20.38 5.00
143 INT14737 Gene_expression of FN1 117 0.78 78.74 18.99 5.00
144 INT192409 Positive_regulation of Gene_expression of IFN1@ 102 0.67 64.66 18.8 5.00
145 INT103245 Positive_regulation of Gene_expression of MMP9 64 0.68 36.86 15.7 5.00
146 INT171666 Regulation of GOPC 117 0.39 40.41 15.47 5.00
147 INT5333 Gene_expression of NPEPPS 45 0.65 26.34 15.25 5.00
148 INT3002 Binding of SUGT1 62 0.24 55.9 14.91 5.00
149 INT24876 Gene_expression of CD34 172 0.78 91.02 12.39 5.00
150 INT3988 Positive_regulation of Gene_expression of IGHE 98 0.68 91.46 9.61 5.00
151 INT36891 Positive_regulation of Gd 39 0.48 34.32 9.43 5.00
152 INT57549 Gene_expression of GNPTAB 49 0.65 57.5 9.05 5.00
153 INT69264 Gene_expression of KIT 207 0.78 179.41 8.95 5.00
154 INT53487 Gene_expression of TSC1 81 0.58 77.71 7.94 5.00
155 INT2971 Regulation of IGHE 42 0.61 28.81 7.87 5.00
156 INT105287 Positive_regulation of Slco1c1 24 0.34 15.41 6.81 5.00
157 INT69441 Regulation of Gene_expression of ROS1 38 0.50 26.78 6.78 5.00
158 INT28122 Gene_expression of MSC 111 0.58 26.83 6.57 5.00
159 INT38672 Binding of KRT20 69 0.39 48.01 6.31 5.00
160 INT89084 Gene_expression of Slco1c1 15 0.51 4.92 6.02 5.00
161 INT16688 Positive_regulation of Cndp2 11 0.49 1.12 5.86 5.00
162 INT71764 Positive_regulation of Mri1 24 0.44 12.31 5.67 5.00
163 INT177584 Gene_expression of MR1 80 0.58 46.48 5.48 5.00
164 INT60585 Regulation of TP53 59 0.59 54.55 5.21 5.00
165 INT22557 Gene_expression of BMP1 3 0.59 20.18 4.73 5.00
166 INT56032 Positive_regulation of NCAM1 38 0.49 26.01 4.68 5.00
167 INT168418 Positive_regulation of RCT 32 0.55 20.2 4.07 5.00
168 INT9144 Localization of MSC 18 0.56 10.17 3.69 5.00
169 INT103674 Positive_regulation of Gene_expression of CXCR4 32 0.69 37.1 3.08 5.00
170 INT8103 Binding of TP53 46 0.44 40.2 2.96 5.00
171 INT154334 Localization of S100A12 9 0.80 9.32 2.89 5.00
172 INT176892 Binding of MR1 36 0.32 15.55 2.58 5.00
173 INT164645 Binding of Csi 9 0.48 4.6 2.46 5.00
174 INT60765 Gene_expression of LAMB2 28 0.49 13.93 2.38 5.00
175 INT56925 Negative_regulation of TSC1 54 0.52 63.39 1.87 5.00
176 INT169862 Regulation of NPC1 13 0.53 13.61 1.84 5.00
177 INT5331 Positive_regulation of Gene_expression of NPEPPS 6 0.49 3.74 1.81 5.00
178 INT174656 Binding of NCF1 5 0.37 6.46 1.65 5.00
179 INT22329 Gene_expression of Ptprc 36 0.66 15.84 1.59 5.00
180 INT28123 Positive_regulation of Gene_expression of MSC 17 0.43 4.02 1.54 5.00
181 INT90377 Gene_expression of HBA1 26 0.75 7.34 1.51 5.00
182 INT133875 Gene_expression of POMT1 26 0.58 17.1 1.48 5.00
183 INT51486 Negative_regulation of GNPTAB 11 0.41 8.18 1.45 5.00
184 INT53929 Positive_regulation of GNPTAB 12 0.32 6.66 1.4 5.00
185 INT21581 Gene_expression of IL4I1 9 0.24 4.21 1.37 5.00
186 INT242902 Gene_expression of NCF1 12 0.78 9.34 1.36 5.00
187 INT61749 Negative_regulation of Csi 9 0.42 4.04 1.35 5.00
188 INT63905 Regulation of RB1 13 0.62 12.67 1.28 5.00
189 INT48192 Gene_expression of Setd1a 8 0.42 4.41 1.26 5.00
190 INT61993 Gene_expression of NF1 29 0.78 34.47 1.23 5.00
191 INT155787 Localization of Csi 4 0.64 1.65 1.19 5.00
192 INT154333 Positive_regulation of Localization of S100A12 4 0.69 3.9 1.19 5.00
193 INT192807 Gene_expression of SSRP1 14 0.49 19.28 1.15 5.00
194 INT93168 Gene_expression of Ttf1 24 0.63 17.18 1.14 5.00
195 INT177593 Positive_regulation of Gene_expression of MR1 17 0.43 9.36 1.13 5.00
196 INT3046 Gene_expression of LGALS1 20 0.75 12.48 1.11 5.00
197 INT231528 Localization of NT5C3 2 0.73 1.78 1.06 5.00
198 INT75846 Positive_regulation of MC4R 7 0.70 5.73 1.05 5.00
199 INT177615 Gene_expression of PAX7 20 0.65 13.5 1.03 5.00
200 INT97052 Transcription of Trp53 12 0.64 6.52 1.01 5.00
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