D:Prion Diseases

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Disease Term
Synonyms Dementia Transmissible, DEMENTIAS TRANSMISSIBLE, Disorder Prion Induced, Disorders Prion Induced, Encephalopathies Spongiform Transmissible, Encephalopathies Transmissible Spongiform, Encephalopathy Transmissible Spongiform, HUMAN TRANSMISSIBLE SPONGIFORM ENCEPHALOPATHIES INHERITED, INHERITED HUMAN TRANSMISSIBLE SPONGIFORM ENCEPHALOPATHIES, Prion Disease, Prion Induced Disorder
Documents 43
Hot Single Events 74
Hot Interactions 4

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Prion Diseases. They are ordered first by their relevance to Prion Diseases and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT268646 Prnp Positive_regulation of PRNP 1 0.08 0.42 0 97.36
2 INT327792 Binding of IGFALS and Alms1 1 0.00 1.15 0.11 96.40
3 INT251944 Binding of GH1 and PRNP 1 0.09 1.14 0.05 93.08
4 INT223753 Tlr4 Positive_regulation of Gene_expression of Il10 4 0.32 1.93 0.78 87.08
5 INT231303 Binding of Prnp and Helt 1 0.02 3.23 0.41 76.48
6 INT231305 Positive_regulation of Binding of Prnp and Helt 1 0.03 1.63 0.19 76.48
7 INT268647 ATP2B3 Positive_regulation of Prnp 1 0.01 0.57 0 70.76
8 INT268648 ATP2B3 Regulation of ATP2B3 Positive_regulation of Prnp 1 0.00 0.57 0 70.76
9 INT335952 Prnp Positive_regulation of can 1 0.17 0.58 0 53.48
10 INT335950 Negative_regulation of Prnp Positive_regulation of can 1 0.16 0.59 0 53.48
11 INT335953 Binding of BCL2 and Bad 1 0.14 0.37 0 50.00
12 INT335951 Binding of Bad and Tgif2lx1 1 0.00 0.37 0 50.00
13 INT324692 Binding of Cd14 and Sod1m 1 0.01 1.07 0.03 27.28
14 INT237907 Tlr4 Positive_regulation of Gene_expression of Tlr2 7 0.40 5.85 0.6 7.48
15 INT206764 Binding of AQP4 and Nqo1 8 0.05 13.45 2.84 5.00
16 INT170367 Binding of Grin1 and Grin2a 5 0.23 1.72 2.79 5.00
17 INT140172 Binding of Nqo1 and IgG 5 0.17 6.68 1.2 5.00
18 INT276964 Binding of Tlr1 and Tlr2 11 0.24 4.22 0.89 5.00
19 INT276988 Binding of Tlr6 and Tlr2 11 0.26 4.89 0.79 5.00
20 INT235975 Binding of AQP4 and IgG 2 0.04 4.11 0.53 5.00
21 INT231304 Prnp Negative_regulation of Grin2d 2 0.38 0.5 0.4 5.00
22 INT324690 Binding of Traf6 and Ticam1 2 0.07 0.23 0.33 5.00
23 INT231306 Prnp Regulation of Grin1 1 0.60 0.35 0.31 5.00
24 INT324694 Tlr4 Positive_regulation of Gene_expression of Pnoc 1 0.05 0.56 0.24 5.00
25 INT327789 Binding of IgG and Alms1 1 0.01 1.1 0.17 5.00
26 INT327790 Binding of Nqo1 and Alms1 1 0.00 1.1 0.17 5.00
27 INT327791 Binding of AQP4 and Alms1 1 0.03 1.1 0.17 5.00
28 INT324691 Tlr6 Positive_regulation of Rcvrn 1 0.01 0 0.12 5.00
29 INT324695 Tlr6 Positive_regulation of Tlr2 1 0.14 0 0.12 5.00
30 INT231301 Prnp Regulation of Regulation of Grin1 1 0.26 0.24 0.08 5.00
31 INT231300 Positive_regulation of Grin2b Positive_regulation of Prnp 1 0.39 0.16 0.05 5.00
32 INT231299 Prnp Regulation of Grin2d 1 0.28 0 0.05 5.00
33 INT231302 Binding of Grin2d and Prnp 1 0.38 0.11 0.05 5.00
34 INT231311 Prnp Negative_regulation of Helt 1 0.04 0.05 0.03 5.00
35 INT231308 Prnp Negative_regulation of Gene_expression of Grin1 1 0.41 0.05 0.03 5.00
36 INT231312 Prnp Negative_regulation of Grin1 1 0.42 0.05 0.03 5.00
37 INT324696 Binding of Myd88 and Mapk10 1 0.05 0.68 0 5.00
38 INT231314 Prnp Positive_regulation of Grin2d Regulation of Prnp 1 0.32 0.16 0 5.00
39 INT231313 Prnp Positive_regulation of Grin2d 1 0.47 0.16 0 5.00
40 INT260518 Binding of Prnp and Gopc 2 0.13 1.06 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Prion Diseases. They are ordered first by their pain relevance and then by number of times they were reported in Prion Diseases. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT102112 Gene_expression of Prnp 440 0.78 209.32 22.5 100.00
2 INT55957 Positive_regulation of PRNP 57 0.67 37.87 7.11 100.00
3 INT100601 Localization of PRNP 17 0.66 13.61 0.71 100.00
4 INT293049 Positive_regulation of Localization of PRNP 1 0.07 2.67 0.09 100.00
5 INT251490 Localization of TSE2 1 0.04 1.71 0 100.00
6 INT69570 Binding of Prnp 75 0.48 44.26 4.37 99.98
7 INT141131 Positive_regulation of Gene_expression of PRNP 12 0.61 16.6 1.36 99.96
8 INT250272 Positive_regulation of Gene_expression of AQP4 11 0.54 9.79 1.85 99.96
9 INT69569 Positive_regulation of Prnp 175 0.70 96.31 13.34 99.84
10 INT335936 Regulation of Negative_regulation of Cabin1 1 0.03 0.98 0 99.80
11 INT204737 Negative_regulation of Gene_expression of Prnp 32 0.59 18.96 1.03 99.74
12 INT46273 Gene_expression of PRNP 103 0.78 110.34 9.25 99.60
13 INT140413 Gene_expression of AQP4 113 0.78 139.25 25.53 99.60
14 INT69572 Localization of Prnp 96 0.81 38.11 5.45 99.52
15 INT78284 Positive_regulation of PTPRC 40 0.49 27.17 3.45 99.50
16 INT335942 Positive_regulation of Cabin1 1 0.05 1.5 0 99.40
17 INT167203 Binding of PRNP 25 0.48 20.09 1.84 99.26
18 INT149985 Gene_expression of Tlr9 32 0.75 29.83 11.86 98.88
19 INT335934 Negative_regulation of Cabin1 1 0.04 0.98 0 98.84
20 INT169926 Positive_regulation of Gopc 416 0.46 157.8 58.67 98.84
21 INT173693 Localization of Gopc 249 0.65 70.49 38.81 98.84
22 INT335938 Negative_regulation of can 1 0.25 4.91 0.17 98.40
23 INT335935 Regulation of can 1 0.12 1.2 0.09 98.40
24 INT50670 Gene_expression of CPOX 763 0.76 442.13 195.02 98.36
25 INT207892 Binding of Tlr9 35 0.46 26.66 6.61 98.08
26 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 97.96
27 INT69571 Positive_regulation of Positive_regulation of Prnp 6 0.70 5.88 0.67 97.72
28 INT50730 Positive_regulation of can 2 0.30 5.37 0.19 97.68
29 INT102253 Negative_regulation of Prnp 75 0.59 24.23 2.62 97.14
30 INT102254 Positive_regulation of Gene_expression of Prnp 72 0.70 38.11 4.81 96.96
31 INT324679 Negative_regulation of Tlr5 1 0.18 1.02 0.22 94.72
32 INT251679 Negative_regulation of Gene_expression of AQP4 2 0.38 10.37 0.77 93.76
33 INT327786 Negative_regulation of Gene_expression of AQP1 3 0.29 4.21 0.44 93.76
34 INT251949 Negative_regulation of Gene_expression of PRNP 6 0.43 4.16 0.3 93.76
35 INT79902 Gene_expression of AQP1 33 0.78 24.72 4.55 93.40
36 INT335939 Positive_regulation of Negative_regulation of can 1 0.21 0.8 0 93.36
37 INT50672 Positive_regulation of CPOX 205 0.44 125.93 60.06 93.00
38 INT178338 Gene_expression of Tbx15 50 0.65 38.65 12.19 92.56
39 INT102255 Regulation of Prnp 35 0.62 18.97 3.25 91.16
40 INT5855 Positive_regulation of Bad 12 0.61 12.26 1.56 91.08
41 INT82055 Positive_regulation of Creb1 176 0.70 60.2 58.39 91.08
42 INT102021 Positive_regulation of Gene_expression of Creb1 66 0.70 24.04 23.28 91.08
43 INT201628 Positive_regulation of Gene_expression of Bad 12 0.68 13.86 0.72 91.08
44 INT63975 Positive_regulation of Il10 175 0.68 134.13 54.69 90.76
45 INT102020 Gene_expression of Creb1 190 0.78 57.31 59.77 90.60
46 INT13385 Gene_expression of Bad 60 0.76 41.86 6.52 90.20
47 INT115708 Phosphorylation of PRNP 2 0.71 1.61 0.26 89.96
48 INT293048 Regulation of Protein_catabolism of PRNP 1 0.06 1.01 0 89.24
49 INT3982 Gene_expression of Acot1 53 0.56 7.61 10.46 88.92
50 INT293047 Protein_catabolism of PRNP 1 0.57 2 0.03 88.84
51 INT335946 Positive_regulation of Positive_regulation of Cabin1 1 0.03 0.64 0 88.16
52 INT140414 Positive_regulation of AQP4 25 0.64 23.43 2.47 87.52
53 INT211054 Positive_regulation of AQP1 3 0.33 4.53 1.41 87.52
54 INT166889 Positive_regulation of Gene_expression of AQP1 10 0.70 6.43 0.99 87.52
55 INT52194 Positive_regulation of Grin1 83 0.69 25.09 34.76 87.28
56 INT136634 Transcription of Prnp 9 0.72 3.34 0.83 87.08
57 INT124164 Protein_catabolism of Prnp 20 1.00 8.58 0.44 86.92
58 INT250282 Negative_regulation of AQP4 32 0.54 32.96 9.07 86.68
59 INT2611 Negative_regulation of AQP1 17 0.39 10.04 2.15 86.68
60 INT268171 Negative_regulation of Binding of Prnp 3 0.42 0.82 0.25 86.64
61 INT60695 Positive_regulation of Gene_expression of Il10 154 0.70 120.28 43.07 86.48
62 INT60694 Gene_expression of Il10 567 0.78 369.48 143.69 86.16
63 INT190664 Regulation of Binding of Prnp 3 0.52 4.29 0.1 86.00
64 INT2038 Localization of Esr1 104 0.79 40.12 13.27 85.04
65 INT271855 Gene_expression of PR@ 11 0.06 11.07 0.61 84.92
66 INT92513 Regulation of Grin1 26 0.59 9.12 13.94 84.60
67 INT245514 Regulation of Gene_expression of Tbx15 3 0.01 2.83 0.98 84.00
68 INT87765 Binding of Acot1 4 0.07 2.59 0.95 83.68
69 INT66200 Gene_expression of Gfap 215 0.78 88.04 28.25 83.60
70 INT50080 Binding of APOE 38 0.45 29.61 2.67 82.96
71 INT251948 Binding of PRND 1 0.35 0.86 0 82.96
72 INT65500 Gene_expression of App 605 0.78 429.94 98.31 82.64
73 INT116249 Positive_regulation of LARS 6 0.39 4.16 0.71 81.48
74 INT231290 Positive_regulation of Positive_regulation of Helt 3 0.03 1.71 0.68 80.48
75 INT17237 Regulation of Esr1 74 0.43 49.09 17.25 79.60
76 INT190667 Binding of PNMA2 1 0.08 2.37 0.66 79.36
77 INT190663 Binding of Mixl1 1 0.19 1.08 0 79.36
78 INT157960 Regulation of AQP4 11 0.48 21.36 3.06 79.04
79 INT297728 Binding of Sod1m 2 0.04 3.45 0.21 77.32
80 INT11796 Positive_regulation of Helt 52 0.31 11.7 29.22 76.48
81 INT5055 Positive_regulation of IFNG 89 0.69 64.03 23.05 74.80
82 INT335949 Positive_regulation of Positive_regulation of PRNP 2 0.25 0.82 0.29 74.12
83 INT60388 Gene_expression of Helt 90 0.07 19.18 41.72 74.08
84 INT135040 Regulation of Gene_expression of Prnp 30 0.62 10.52 2.45 72.56
85 INT95694 Gene_expression of Chrnb1 6 0.36 4.27 1.33 71.96
86 INT240280 Gene_expression of IGFALS 14 0.42 20.38 0.95 71.52
87 INT327784 Regulation of Gene_expression of IGFALS 1 0.07 1.21 0.13 71.52
88 INT9385 Localization of LDHA 74 0.81 31.67 10.5 70.64
89 INT190665 Gene_expression of Mixl1 4 0.35 2.54 0.2 70.52
90 INT24225 Gene_expression of Alms1 93 0.62 52.75 16.93 69.60
91 INT5207 Negative_regulation of Alms1 70 0.41 41.56 13.68 69.60
92 INT230495 Regulation of Gene_expression of Alms1 4 0.04 4.53 0.53 69.60
93 INT327778 Positive_regulation of Regulation of AQP4 1 0.37 2.84 0.07 69.44
94 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 68.88
95 INT3361 Positive_regulation of Esr1 273 0.69 208.53 44.81 68.76
96 INT288332 Localization of Sod1m 2 0.04 2.41 0.17 68.52
97 INT85621 Regulation of PRNP 16 0.60 8.7 1.15 68.40
98 INT315419 Protein_catabolism of Chrnb1 1 0.03 0.14 0 66.12
99 INT324681 Positive_regulation of Tlr1 2 0.22 2.02 0.05 62.72
100 INT23564 Negative_regulation of Car2 103 0.50 27.28 21.86 62.32
101 INT1561 Negative_regulation of Dnahc8 59 0.59 18.12 20.99 62.32
102 INT160670 Negative_regulation of Pdia3 3 0.42 0.7 0.22 62.32
103 INT725 Negative_regulation of IgG 62 0.41 37.21 8.16 60.44
104 INT36799 Negative_regulation of Ighm 21 0.41 17.47 3.65 60.44
105 INT222089 Positive_regulation of Localization of Esr1 19 0.49 8.73 1.58 59.20
106 INT69568 Positive_regulation of Localization of Prnp 5 0.50 2.43 0.26 59.16
107 INT230195 Negative_regulation of LDLRAP1 1 0.04 0.88 0 59.00
108 INT273338 Protein_catabolism of Apex1 4 0.05 0.57 0.09 57.08
109 INT230198 Gene_expression of LDLRAP1 1 0.06 0.87 0 56.52
110 INT47712 Positive_regulation of App 135 0.69 101.38 28.94 55.72
111 INT127714 Negative_regulation of GEM 6 0.37 2.24 1.01 52.24
112 INT57380 Phosphorylation of Creb1 213 0.82 66.8 71.26 50.00
113 INT170054 Negative_regulation of Gopc 280 0.38 117.89 42.4 50.00
114 INT62577 Negative_regulation of Creb1 55 0.59 19.68 18.1 50.00
115 INT121796 Gene_expression of NeuN 92 0.78 23.18 10.53 50.00
116 INT121866 Localization of Creb1 13 0.73 1.95 4.48 50.00
117 INT143591 Binding of NeuN 10 0.31 2.23 2.22 50.00
118 INT172874 Phosphorylation of Bad 31 0.80 27.46 2.07 50.00
119 INT170900 Regulation of Positive_regulation of Gopc 10 0.20 3.44 1.24 50.00
120 INT70019 Binding of BCL2 25 0.47 17.55 0.79 50.00
121 INT131891 Localization of Cabin1 2 0.05 1.43 0.59 50.00
122 INT229518 Phosphorylation of Prnp 5 0.69 1.62 0.27 50.00
123 INT335945 Phosphorylation of can 1 0.35 0.16 0.09 50.00
124 INT229519 Regulation of Localization of Prnp 4 0.61 0.7 0.03 50.00
125 INT335943 Regulation of Negative_regulation of can 1 0.12 0.22 0 50.00
126 INT335941 Gene_expression of Cabin1 1 0.04 0.38 0 50.00
127 INT335944 Localization of can 1 0.13 0.3 0 50.00
128 INT335937 Negative_regulation of Phosphorylation of Bad 1 0.15 0.41 0 50.00
129 INT335940 Binding of can 1 0.16 0.43 0 50.00
130 INT240689 Gene_expression of FCMTE1 3 0.15 1.31 0 49.88
131 INT230197 Binding of LDLRAP1 1 0.03 0.63 0 41.48
132 INT230181 Binding of Aurka 2 0.35 0.63 0.03 41.12
133 INT72747 Localization of IgG 55 0.53 30.88 4.19 38.76
134 INT206760 Localization of Nqo1 8 0.09 15.76 2.4 38.40
135 INT315418 Negative_regulation of Slc26a5 1 0.01 0.63 0 37.60
136 INT4509 Gene_expression of IgG 426 0.76 293.69 56.64 35.00
137 INT77855 Gene_expression of Pain1 55 0.75 67.42 54.1 35.00
138 INT140411 Gene_expression of Nqo1 45 0.60 62.35 8.7 35.00
139 INT271856 Positive_regulation of Positive_regulation of PR@ 1 0.02 1 0 30.28
140 INT239100 Positive_regulation of PR@ 4 0.37 8.28 2.73 29.20
141 INT71363 Binding of Rvm 9 0.31 3.23 10.83 27.52
142 INT185738 Binding of Cd14 28 0.45 14.41 3.25 27.04
143 INT190666 Positive_regulation of Binding of Prnp 2 0.50 1.87 0 26.64
144 INT69264 Gene_expression of KIT 207 0.78 179.41 8.95 24.56
145 INT264686 Positive_regulation of Gene_expression of IGFALS 2 0.28 2.21 0.27 15.76
146 INT324684 Positive_regulation of Transcription of MGAT1 1 0.06 0.88 0.09 15.76
147 INT324685 Transcription of MGAT1 1 0.08 0.88 0.09 15.76
148 INT240281 Positive_regulation of IGFALS 11 0.31 10.44 0.56 15.28
149 INT24042 Gene_expression of MUC5AC 98 0.77 74.99 6.18 12.16
150 INT92515 Gene_expression of Grin2a 84 0.76 26.68 38.37 10.48
151 INT142594 Gene_expression of Tlr2 165 0.78 139.73 22.26 6.64
152 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
153 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 5.00
154 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 5.00
155 INT7533 Gene_expression of Tlr4 720 0.78 343.22 121.57 5.00
156 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61 5.00
157 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83 5.00
158 INT56291 Gene_expression of Ros1 503 0.63 274.12 81.5 5.00
159 INT92518 Gene_expression of Grin2b 131 0.78 65.52 80.91 5.00
160 INT1951 Positive_regulation of Tlr4 345 0.70 176.99 62.42 5.00
161 INT29144 Gene_expression of Rvm 41 0.52 29.23 47.76 5.00
162 INT85943 Negative_regulation of Nos2 161 0.59 108.56 42.65 5.00
163 INT94029 Positive_regulation of Grin2b 58 0.70 24.2 42.52 5.00
164 INT64440 Gene_expression of Pnoc 66 0.78 13.61 41.76 5.00
165 INT11939 Negative_regulation of Il6 138 0.59 87.46 41.24 5.00
166 INT69437 Positive_regulation of ROS1 328 0.58 222.83 40.56 5.00
167 INT92517 Gene_expression of Grin1 105 0.78 29.53 39.43 5.00
168 INT81289 Positive_regulation of Gene_expression of Tlr4 192 0.69 104.5 33.89 5.00
169 INT9658 Negative_regulation of Gene_expression of Il6 110 0.59 66.29 32.58 5.00
170 INT96913 Positive_regulation of Mapk8 179 0.69 130.44 32.2 5.00
171 INT93451 Positive_regulation of Gene_expression of Grin2b 43 0.70 29.09 31.89 5.00
172 INT56809 Binding of Tlr4 184 0.48 106.02 31.18 5.00
173 INT32794 Gene_expression of Grin2d 81 0.68 20.87 26.99 5.00
174 INT107577 Negative_regulation of Grin2b 32 0.59 12.35 24.88 5.00
175 INT172458 Regulation of Gopc 155 0.53 62.57 24.86 5.00
176 INT78057 Localization of Tlr4 140 0.77 67.75 21.72 5.00
177 INT7535 Negative_regulation of Tlr4 111 0.56 56.84 21.37 5.00
178 INT955 Gene_expression of GHRH 126 0.78 59.91 20.74 5.00
179 INT12265 Positive_regulation of IgG 168 0.63 104.89 19.76 5.00
180 INT13244 Binding of Helt 30 0.31 4.56 18.01 5.00
181 INT63928 Negative_regulation of Grin1 51 0.56 11.81 17.57 5.00
182 INT170051 Positive_regulation of Gene_expression of Gopc 150 0.43 56.75 16.93 5.00
183 INT171666 Regulation of GOPC 117 0.39 40.41 15.47 5.00
184 INT170855 Negative_regulation of GOPC 188 0.38 70.92 15.41 5.00
185 INT14647 Positive_regulation of Grin2a 26 0.67 4.69 14.8 5.00
186 INT11795 Negative_regulation of Helt 33 0.28 6.51 14.76 5.00
187 INT36177 Binding of Alms1 70 0.31 35.47 13.81 5.00
188 INT69435 Negative_regulation of ROS1 74 0.51 50.38 13.71 5.00
189 INT142593 Positive_regulation of Tlr2 85 0.70 75.9 13.62 5.00
190 INT27268 Localization of Gtf3a 71 0.21 56.93 12.51 5.00
191 INT135022 Gene_expression of Cd14 79 0.76 36.37 10.63 5.00
192 INT20205 Binding of IgG 108 0.46 66.68 8.57 5.00
193 INT95414 Positive_regulation of Alms1 40 0.41 20.3 8.1 5.00
194 INT117642 Regulation of Gene_expression of Grin1 18 0.53 7.09 8.08 5.00
195 INT157959 Binding of AQP4 32 0.48 43.44 7.44 5.00
196 INT10478 Protein_catabolism of Alms1 25 0.47 12.95 7.19 5.00
197 INT140170 Binding of Nqo1 24 0.38 36.16 6.79 5.00
198 INT142596 Positive_regulation of Gene_expression of Tlr2 42 0.69 38.41 6.67 5.00
199 INT9695 Negative_regulation of Csf2 41 0.57 31.65 6.28 5.00
200 INT84704 Positive_regulation of Nqo1 18 0.70 18.64 5.65 5.00
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