D:Proctocolitis

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Disease Term
Synonyms Hemorrhagic Proctocolitis, Hemorrhagic Rectocolitis, PROCTOCOLITIDES ULCERATIVE, PROCTOCOLITIS HEMORRHAGIC, Proctocolitis Ulcerative, Proctosigmoiditis, Rectocolitides Ulcerative, Rectocolitis, Rectocolitis Hemorrhagic, RECTOCOLITIS ULCERATIVE, Rectosigmoiditis
Documents 52
Hot Single Events 3
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Proctocolitis. They are ordered first by their relevance to Proctocolitis and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT290667 Il6 Positive_regulation of Stat3 3 0.69 2.42 1.15 5.00
2 INT290671 Binding of Socs3 and Stat3 2 0.23 1.59 0.45 5.00
3 INT290672 Stat3 Negative_regulation of Il6 1 0.08 0.4 0.18 5.00
4 INT290670 Binding of Nos2 and Ppara 1 0.17 0.41 0.16 5.00
5 INT290673 Ppara Positive_regulation of Gtf3a 1 0.01 0.58 0.09 5.00
6 INT290674 Ppara Positive_regulation of Gtf3a Positive_regulation of Ppara 1 0.01 0.58 0.09 5.00
7 INT290669 Tlr4 Positive_regulation of Binding of Il6 1 0.02 0.07 0.08 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Proctocolitis. They are ordered first by their pain relevance and then by number of times they were reported in Proctocolitis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT355463 Gene_expression of SPRED1 1 0.56 6.96 0.24 93.44
2 INT355461 Localization of SPRED1 1 0.63 3.48 0.04 87.44
3 INT355462 Negative_regulation of SPRED1 1 0.36 1.34 0.16 85.84
4 INT27314 Negative_regulation of CNOT4 4 0.00 1.64 0.98 71.64
5 INT27313 Negative_regulation of OAT 2 0.17 0.69 0.46 71.64
6 INT7336 Positive_regulation of VIP 60 0.70 24.2 19.62 56.68
7 INT157664 Positive_regulation of DEFB4A 15 0.56 10.87 3.8 44.04
8 INT169318 Positive_regulation of Rxra 15 0.42 4.35 2.12 31.24
9 INT114274 Gene_expression of Rxra 67 0.70 36.77 12.5 21.08
10 INT122039 Positive_regulation of Gene_expression of Ppara 144 0.68 113.55 28.55 18.80
11 INT115386 Gene_expression of Ppara 779 0.77 549.99 128.36 18.60
12 INT122037 Regulation of Ppara 93 0.62 56.28 12.89 15.40
13 INT130082 Regulation of Rxra 6 0.42 3.78 1.96 15.40
14 INT194479 Phosphorylation of Ppara 47 0.81 30.36 6.6 7.76
15 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
16 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 5.00
17 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 5.00
18 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 5.00
19 INT867 Gene_expression of IFNA1 930 0.78 594.85 168.03 5.00
20 INT66280 Gene_expression of Nos2 534 0.78 330.78 157.07 5.00
21 INT60694 Gene_expression of Il10 567 0.78 369.48 143.69 5.00
22 INT12339 Localization of IL8 437 0.81 251.87 117.39 5.00
23 INT20374 Gene_expression of Il4 515 0.76 306.15 114.12 5.00
24 INT11051 Positive_regulation of Gene_expression of IL6 415 0.69 319.21 109.3 5.00
25 INT10838 Positive_regulation of IL8 381 0.70 295.51 101.62 5.00
26 INT11381 Positive_regulation of IL1B 330 0.70 209.31 100.9 5.00
27 INT77435 Positive_regulation of Nos2 343 0.70 208.49 91.43 5.00
28 INT84546 Positive_regulation of Ppara 481 0.70 334.21 83.45 5.00
29 INT60691 Gene_expression of Il12a 331 0.78 208.03 75.96 5.00
30 INT14049 Positive_regulation of GRIN1 102 0.70 48.31 71.06 5.00
31 INT10837 Positive_regulation of Gene_expression of IL8 294 0.70 190.08 70.34 5.00
32 INT11807 Gene_expression of Il2 266 0.78 112 64.97 5.00
33 INT1951 Positive_regulation of Tlr4 345 0.70 176.99 62.42 5.00
34 INT11318 Gene_expression of Gtf3a 274 0.52 183.82 60.89 5.00
35 INT5058 Positive_regulation of IFNA1 356 0.70 245.75 60.52 5.00
36 INT20375 Gene_expression of Hand1 213 0.60 148.51 54.53 5.00
37 INT122041 Binding of Ppara 308 0.48 189.17 51.48 5.00
38 INT20382 Gene_expression of Hand2 211 0.66 142.26 51.05 5.00
39 INT6473 Positive_regulation of Gene_expression of IL1B 204 0.70 117.23 50.86 5.00
40 INT18522 Positive_regulation of Gene_expression of IFNA1 248 0.67 160.85 44.87 5.00
41 INT8465 Regulation of Ptgs1 100 0.57 36.03 44.41 5.00
42 INT100939 Gene_expression of Il13 176 0.73 125.1 43.38 5.00
43 INT60695 Positive_regulation of Gene_expression of Il10 154 0.70 120.28 43.07 5.00
44 INT85943 Negative_regulation of Nos2 161 0.59 108.56 42.65 5.00
45 INT11939 Negative_regulation of Il6 138 0.59 87.46 41.24 5.00
46 INT77307 Gene_expression of Bcl2 399 0.77 319.77 38 5.00
47 INT48222 Positive_regulation of Localization of IL8 123 0.59 78.04 37.2 5.00
48 INT20380 Gene_expression of Il5 172 0.78 104.75 34.78 5.00
49 INT2732 Gene_expression of VIP 74 0.78 24.57 33.72 5.00
50 INT6302 Binding of IFNA1 196 0.48 133.85 32.73 5.00
51 INT92837 Negative_regulation of Gene_expression of Nos2 116 0.59 59.67 31.82 5.00
52 INT10506 Gene_expression of PTAFR 86 0.76 37.57 28.58 5.00
53 INT115385 Negative_regulation of Ppara 154 0.58 129.05 27.58 5.00
54 INT16428 Positive_regulation of Gtf3a 135 0.20 106.44 26.67 5.00
55 INT10836 Negative_regulation of IL8 95 0.59 52.59 24.71 5.00
56 INT23257 Regulation of CRP 127 0.62 100.05 21.87 5.00
57 INT14700 Regulation of IFNA1 111 0.45 66.16 21.52 5.00
58 INT52106 Negative_regulation of Localization of IL8 57 0.52 22.81 20.8 5.00
59 INT86751 Negative_regulation of Il10 62 0.59 40.1 20.51 5.00
60 INT49985 Transcription of Il6 62 0.72 40.13 20.29 5.00
61 INT14701 Negative_regulation of IFNA1 118 0.54 84.19 20.08 5.00
62 INT138696 Positive_regulation of Ccl2 57 0.67 59.57 19.58 5.00
63 INT34057 Negative_regulation of Gene_expression of IFNA1 65 0.58 43.46 17.25 5.00
64 INT77433 Regulation of Gene_expression of Nos2 49 0.62 35.07 16.33 5.00
65 INT142464 Gene_expression of Socs3 58 0.77 52.04 15.34 5.00
66 INT129584 Positive_regulation of Stat3 97 0.68 87.07 14.86 5.00
67 INT34904 Negative_regulation of Gtf3a 48 0.15 38.88 13.73 5.00
68 INT69878 Positive_regulation of Gene_expression of Gtf3a 48 0.29 36.78 13.57 5.00
69 INT54763 Binding of Il6 82 0.48 63.27 12.89 5.00
70 INT94464 Negative_regulation of Hand1 44 0.41 31.5 12.39 5.00
71 INT194462 Localization of Ppara 94 0.78 68.33 12.09 5.00
72 INT5045 Regulation of VIP 26 0.62 7.15 11.61 5.00
73 INT94465 Positive_regulation of Gene_expression of Hand1 43 0.38 29.76 10.88 5.00
74 INT3180 Positive_regulation of PPY 39 0.63 25.57 10.15 5.00
75 INT114874 Gene_expression of Stat3 78 0.76 53.99 9.49 5.00
76 INT132586 Negative_regulation of Hand2 40 0.30 26.58 9.28 5.00
77 INT93045 Negative_regulation of Gene_expression of Hand2 31 0.43 25.26 9.24 5.00
78 INT142462 Positive_regulation of Gene_expression of Socs3 23 0.68 23.27 8.27 5.00
79 INT114873 Phosphorylation of Stat3 63 0.82 30.19 8.23 5.00
80 INT30526 Negative_regulation of PTAFR 15 0.58 8.15 8.19 5.00
81 INT101189 Transcription of Gtf3a 49 0.17 24.39 7.93 5.00
82 INT77306 Negative_regulation of Gene_expression of Bcl2 46 0.58 38.05 7.71 5.00
83 INT181817 Negative_regulation of Gene_expression of Ppara 58 0.58 43.24 7.67 5.00
84 INT18524 Regulation of Gene_expression of IFNA1 37 0.44 18.79 7.62 5.00
85 INT138922 Positive_regulation of Stat1 57 0.69 28.35 7.2 5.00
86 INT93046 Positive_regulation of Gene_expression of Hand2 27 0.47 24.54 7.01 5.00
87 INT138799 Regulation of Gene_expression of Ppara 40 0.60 29.42 6.89 5.00
88 INT104909 Binding of Pias1 11 0.37 3.67 6.72 5.00
89 INT48239 Binding of Gtf3a 52 0.33 23.14 6.45 5.00
90 INT48234 Negative_regulation of Gene_expression of PTAFR 11 0.57 3.97 6.25 5.00
91 INT97797 Localization of TLR4 18 0.77 13.78 6 5.00
92 INT75833 Negative_regulation of Positive_regulation of IL8 15 0.53 6.69 5.59 5.00
93 INT87022 Gene_expression of Apc 68 0.67 46.98 5.22 5.00
94 INT122038 Transcription of Ppara 35 0.71 20.5 5.12 5.00
95 INT141275 Negative_regulation of Gene_expression of Hand1 18 0.34 15.83 5.05 5.00
96 INT97878 Positive_regulation of Pias1 6 0.50 2.73 4.65 5.00
97 INT202417 Gene_expression of Gata3 16 0.61 7.84 4.12 5.00
98 INT156131 Binding of Hand2 14 0.25 10.35 3.99 5.00
99 INT3817 Negative_regulation of Apc 29 0.58 22.12 3.91 5.00
100 INT66924 Positive_regulation of Transcription of Il6 18 0.68 11.8 3.53 5.00
101 INT184060 Negative_regulation of Stat1 28 0.58 17.44 3.19 5.00
102 INT240544 Gene_expression of TBX21 12 0.75 5.96 2.97 5.00
103 INT114878 Positive_regulation of Gene_expression of Stat3 15 0.49 10.81 2.91 5.00
104 INT11920 Regulation of ENO2 18 0.55 11.51 2.89 5.00
105 INT142465 Negative_regulation of Socs3 8 0.48 8.31 2.62 5.00
106 INT202419 Positive_regulation of Gene_expression of Gata3 6 0.52 5.47 2.6 5.00
107 INT112962 Regulation of Positive_regulation of Ppara 17 0.45 10.63 2.58 5.00
108 INT215379 Positive_regulation of Binding of Ppara 15 0.66 8.04 2.36 5.00
109 INT178193 Negative_regulation of Stat3 25 0.58 17.82 2.27 5.00
110 INT211984 Regulation of Binding of Ppara 11 0.45 9.55 1.87 5.00
111 INT91664 Positive_regulation of Negative_regulation of IL8 5 0.40 3.28 1.62 5.00
112 INT186309 Binding of Stat1 18 0.48 5.31 1.58 5.00
113 INT184032 Regulation of Socs3 6 0.37 4.08 1.48 5.00
114 INT100672 Transcription of Hand2 9 0.42 2.84 1.47 5.00
115 INT116014 Transcription of Gata3 4 0.63 2.24 1.46 5.00
116 INT43899 Positive_regulation of Positive_regulation of VIP 4 0.57 1.71 1.42 5.00
117 INT55950 Negative_regulation of Pias1 4 0.37 1.31 1.36 5.00
118 INT190880 Binding of Ncor2 11 0.27 2.24 1.34 5.00
119 INT197167 Positive_regulation of Localization of Ppara 18 0.67 9.51 1.21 5.00
120 INT183635 Negative_regulation of Positive_regulation of Ppara 11 0.42 10 1.2 5.00
121 INT242134 Localization of Apc 8 0.74 4.83 0.88 5.00
122 INT193334 Gene_expression of HPYR1 11 0.53 10.36 0.88 5.00
123 INT178186 Regulation of Stat3 7 0.44 6.23 0.74 5.00
124 INT202416 Negative_regulation of Gata3 2 0.32 1.17 0.64 5.00
125 INT290660 Negative_regulation of Gene_expression of Gata3 1 0.25 1.52 0.6 5.00
126 INT205477 Transcription of Stat3 4 0.68 3.15 0.5 5.00
127 INT263932 Positive_regulation of PROCR 6 0.67 2.43 0.46 5.00
128 INT197168 Regulation of Localization of Ppara 6 0.39 3.7 0.41 5.00
129 INT138910 Negative_regulation of Positive_regulation of Stat1 3 0.57 0.81 0.39 5.00
130 INT81644 Regulation of Ctnnb1 5 0.41 3.38 0.37 5.00
131 INT276919 Regulation of Phosphorylation of Stat3 3 0.35 1.32 0.27 5.00
132 INT290657 Gene_expression of Tbx21 1 0.10 0.09 0.17 5.00
133 INT290656 Positive_regulation of Gene_expression of Tbx21 1 0.08 0.09 0.17 5.00
134 INT290661 Regulation of Regulation of Stat3 1 0.29 0.36 0.14 5.00
135 INT290655 Positive_regulation of Transcription of Stat3 1 0.33 0.41 0.13 5.00
136 INT262100 Gene_expression of Ncor2 3 0.42 0.31 0.12 5.00
137 INT203727 Negative_regulation of Phosphorylation of Ppara 4 0.42 3.54 0.07 5.00
138 INT355460 Positive_regulation of SPRED1 1 0.42 0.37 0 5.00
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