D:Prolactinoma

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Disease Term
Synonyms Adenoma Lactotroph, Adenoma Prolactin Secreting Pituitary, Adenomas Lactotroph, Lactotroph Adenoma, Lactotroph Adenomas, Macroprolactinoma, Macroprolactinomas, Microprolactinoma, MICROPROLACTINOMAS, Pituitary Adenoma Prl Secreting, Pituitary Adenoma Prolactin Producing
Documents 199
Hot Single Events 144
Hot Interactions 9

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Prolactinoma. They are ordered first by their relevance to Prolactinoma and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT39738 PRL Regulation of Localization of GH1 1 0.37 0.6 0.24 98.88
2 INT45738 TRH Positive_regulation of TRH Regulation of Prl 2 0.51 0.61 0.17 95.96
3 INT25036 TRH Regulation of Prl 4 0.27 1.75 1.09 95.68
4 INT196951 Hmga2 Positive_regulation of E2f1 1 0.50 0.98 0 93.56
5 INT212013 RAD51D Negative_regulation of ALPP 1 0.00 0.7 0 91.20
6 INT196961 Binding of Hmga2 and Rb1 1 0.48 6.47 0 90.32
7 INT36008 Negative_regulation of Binding of Drd2 and Prl 1 0.01 2.11 0.85 87.68
8 INT36009 Binding of Drd2 and Prl 1 0.01 1.05 0.42 87.68
9 INT33135 Binding of NFKBIL1 and PRL 1 0.09 0.29 1.01 80.76
10 INT212014 RAD51D Positive_regulation of Gene_expression of PRL 1 0.06 0.77 0 78.48
11 INT222474 Binding of Fgf1 and Ecm1 1 0.00 0.62 0 75.96
12 INT202270 Pttg1 Positive_regulation of Myc 1 0.28 0.84 0.03 69.44
13 INT196950 Binding of Rb1 and E2f2 1 0.01 0.6 0 66.76
14 INT212009 Binding of PRL and PTHLH 1 0.32 0.48 0 64.76
15 INT196964 Binding of E2f1 and Rb1 Negative_regulation of Transcription of E2f1 1 0.46 0.6 0 56.64
16 INT196955 Binding of E2f1 and Rb1 1 0.36 1 0 56.16
17 INT196963 Binding of E2f1 and Rb1 Negative_regulation of E2f1 1 0.46 0.6 0 56.16
18 INT316544 BCL2L11 Regulation of INS 1 0.00 1.36 0.77 50.00
19 INT28947 GH1 Positive_regulation of Gene_expression of IGF1 4 0.22 3.78 0.69 50.00
20 INT316546 Binding of GH1 and SST 2 0.03 0.55 0.54 50.00
21 INT292814 Binding of VEGFA and Kdr 8 0.18 3.63 0.48 50.00
22 INT316545 Binding of IGF1 and SST 1 0.06 0.45 0.37 50.00
23 INT78444 Binding of GH1 and IGF1 4 0.16 2.82 0.37 50.00
24 INT316543 GH1 Regulation of Gene_expression of IGF1 1 0.03 1.32 0.09 50.00
25 INT316552 Binding of SST and Sst1 1 0.03 0.53 0.09 50.00
26 INT312330 Binding of Kdr and Flt1 1 0.12 0.37 0 50.00
27 INT300448 Binding of VEGFA and Flt1 3 0.10 1.93 0 50.00
28 INT312331 Binding of Flt1 and Pgf 1 0.08 0.31 0 50.00
29 INT196958 Phosphorylation of Rb1 Positive_regulation of Localization of E2f1 1 0.45 0.44 0 47.36
30 INT196954 Binding of Atp8a1 and E2f1 1 0.40 0.49 0 32.72
31 INT196946 Binding of E2f1 and Hdac1 1 0.26 0.65 0 32.72
32 INT212011 RAD51D Regulation of Localization of GNRH1 1 0.04 0.59 0 27.36
33 INT212012 RAD51D Regulation of GNRH1 1 0.04 0.59 0 26.56
34 INT215035 Trh Positive_regulation of Gh 1 0.07 0.89 0 23.12
35 INT285748 PRL Positive_regulation of Positive_regulation of C6orf25 1 0.01 1.01 0.31 22.20
36 INT222464 Col4a2 Regulation of Localization of Prl 1 0.03 0.32 0.3 15.44
37 INT2161 Gnrh1 Positive_regulation of Localization of LH 33 0.73 0.87 14.34 5.00
38 INT16531 Ghrh Positive_regulation of Localization of Gh1 31 0.64 2.12 14.2 5.00
39 INT2714 Pomc Positive_regulation of Localization of Prl 17 0.79 0.5 8.18 5.00
40 INT20133 Trh Positive_regulation of Localization of Prl 23 0.78 2.04 5.44 5.00
41 INT1392 Trh Regulation of Prl 15 0.29 2.47 4.29 5.00
42 INT222522 Il1a Positive_regulation of Gene_expression of Il6 2 0.06 1.79 2.79 5.00
43 INT9786 Gnrh1 Regulation of LH 7 0.40 0.58 1.82 5.00
44 INT78066 Tlr4 Positive_regulation of Localization of Il6 5 0.03 0.76 1.25 5.00
45 INT62368 Gal Positive_regulation of Localization of LH 3 0.36 0 1.2 5.00
46 INT222516 Binding of Calcrl and Ramp1 5 0.17 0.11 1.12 5.00
47 INT36186 Npy Positive_regulation of Localization of Gnrh1 4 0.75 0.09 0.96 5.00
48 INT206857 Binding of Calca and Calcrl 4 0.37 1.9 0.95 5.00
49 INT232426 HRH2 Regulation of Localization of PRL 1 0.15 0.38 0.94 5.00
50 INT78062 Il1a Positive_regulation of Localization of Il6 3 0.24 0.48 0.9 5.00
51 INT222528 Abat Positive_regulation of Gene_expression of Gh1 1 0.01 0 0.75 5.00
52 INT123229 OXTR Regulation of Localization of PRL 2 0.30 0 0.73 5.00
53 INT222432 Binding of Tlr4 and Cd14 1 0.02 0.74 0.71 5.00
54 INT222493 Edn1 Positive_regulation of Localization of Prl 1 0.10 0 0.71 5.00
55 INT32715 Prl Regulation of Localization of LH 2 0.34 0.09 0.68 5.00
56 INT60283 Positive_regulation of Gnrh1 Regulation of LH 2 0.31 0 0.68 5.00
57 INT222552 Abat Regulation of Gene_expression of Gh1 1 0.00 0 0.67 5.00
58 INT339794 Sstr2 Positive_regulation of Gene_expression of Sstr5 1 0.08 0.25 0.64 5.00
59 INT222492 Ngf Positive_regulation of Gene_expression of Prl 1 0.24 0 0.62 5.00
60 INT3617 Trh Regulation of Localization of Gh1 3 0.65 0.55 0.62 5.00
61 INT89902 SST Positive_regulation of Localization of PRL 2 0.40 0 0.61 5.00
62 INT27067 Crh Positive_regulation of Localization of Avp 3 0.18 0.46 0.61 5.00
63 INT32747 Avp Positive_regulation of Localization of Pomc 4 0.16 1.92 0.61 5.00
64 INT222521 Vip Positive_regulation of Localization of Ngf 1 0.14 0.08 0.6 5.00
65 INT60536 Gnrh1 Positive_regulation of Localization of Prl 2 0.22 1.12 0.6 5.00
66 INT222554 Il1a Positive_regulation of Localization of Ngf 1 0.02 0.07 0.6 5.00
67 INT156668 Gh Positive_regulation of Igf1 5 0.22 2.07 0.57 5.00
68 INT232424 VIP Positive_regulation of Localization of PRL 1 0.36 0 0.53 5.00
69 INT222524 Abat Negative_regulation of Localization of Trh 1 0.02 0.16 0.51 5.00
70 INT232427 ABAT Regulation of PRL 1 0.08 0.26 0.45 5.00
71 INT222490 Npy Positive_regulation of Localization of Gh1 1 0.02 0.06 0.41 5.00
72 INT285746 IL6 Regulation of Localization of PRL 1 0.08 1.51 0.39 5.00
73 INT285749 IL6 Positive_regulation of Localization of PRL 1 0.08 1.51 0.39 5.00
74 INT222418 Tlr4 Positive_regulation of Gene_expression of Il1a 1 0.00 0.31 0.39 5.00
75 INT285750 IL1B Positive_regulation of Localization of PRL 1 0.05 1.51 0.39 5.00
76 INT285744 IL1B Regulation of Localization of PRL 1 0.05 1.51 0.39 5.00
77 INT232422 VIP Regulation of Gene_expression of PRL 1 0.40 0 0.37 5.00
78 INT232421 Binding of PRL and Positive_regulation of Regulation of ABAT 1 0.09 0 0.37 5.00
79 INT3616 Trh Positive_regulation of Localization of Gh1 4 0.73 0.49 0.36 5.00
80 INT232419 ABAT Positive_regulation of Localization of PRL 1 0.09 0 0.33 5.00
81 INT232425 Binding of ABAT and Positive_regulation of PRL 1 0.09 0.15 0.33 5.00
82 INT232420 PRL Positive_regulation of Regulation of ABAT 1 0.09 0 0.33 5.00
83 INT222441 Tlr4 Positive_regulation of Gene_expression of Tac1 1 0.00 0.39 0.32 5.00
84 INT341777 SLC6A4 Regulation of EPHB1 1 0.02 0.96 0.3 5.00
85 INT222529 Binding of Trh and Vip 1 0.07 0.09 0.29 5.00
86 INT126696 Binding of Crhr1 and Crh 3 0.50 0.44 0.29 5.00
87 INT323152 Binding of DBT and ESR1 2 0.02 1.29 0.27 5.00
88 INT222428 Negative_regulation of Tlr4 Positive_regulation of Il6 1 0.01 0.26 0.27 5.00
89 INT222412 Cd14 Negative_regulation of Binding of Tlr4 1 0.02 0.26 0.27 5.00
90 INT222440 Tlr4 Positive_regulation of Localization of Pomc 1 0.01 0.35 0.27 5.00
91 INT222427 Il6 Positive_regulation of Localization of Pomc 1 0.02 0.27 0.26 5.00
92 INT222422 Tlr4 Positive_regulation of Il6 1 0.01 0.25 0.26 5.00
93 INT222467 Gh1 Positive_regulation of Prl 1 0.04 0.52 0.26 5.00
94 INT222557 Gal Positive_regulation of Gene_expression of Vip 1 0.06 0.07 0.25 5.00
95 INT222421 Tlr4 Negative_regulation of Localization of Prl 1 0.02 0.45 0.25 5.00
96 INT222563 Vip Positive_regulation of Gene_expression of Il6 1 0.05 0.38 0.25 5.00
97 INT222560 Calca Positive_regulation of Gene_expression of Il6 1 0.06 0.39 0.25 5.00
98 INT222540 Mzb1 Positive_regulation of Gene_expression of Il6 1 0.03 0.38 0.25 5.00
99 INT215037 Ghrh Regulation of Localization of Igf2 1 0.04 2.12 0.24 5.00
100 INT222561 Gnrh1 Positive_regulation of Prl 1 0.15 0.38 0.22 5.00
101 INT341779 DBT Positive_regulation of PRKCA 1 0.02 0 0.22 5.00
102 INT285745 IL31RA Positive_regulation of Gene_expression of MPL 1 0.19 1.04 0.22 5.00
103 INT222527 Gal Regulation of Vip 1 0.03 0.05 0.22 5.00
104 INT341778 DBT Positive_regulation of MAP2K6 1 0.00 0 0.21 5.00
105 INT197811 Binding of SMS and SST 1 0.00 0.98 0.21 5.00
106 INT222566 Agt Positive_regulation of Localization of Prl 1 0.08 0.23 0.21 5.00
107 INT222482 Lep Positive_regulation of Localization of Gh1 1 0.02 1.02 0.2 5.00
108 INT222568 Vip Negative_regulation of Transcription of Nos2 1 0.06 0.3 0.19 5.00
109 INT222543 Il1a Regulation of Chat 1 0.01 0.64 0.19 5.00
110 INT222525 Il1a Regulation of Localization of Gh1 1 0.00 0.64 0.19 5.00
111 INT222499 Il10 Regulation of Positive_regulation of Hpse 1 0.00 0.8 0.19 5.00
112 INT222473 Mzb1 Negative_regulation of Transcription of Nos2 1 0.04 0.29 0.19 5.00
113 INT222494 Negative_regulation of Il1a Negative_regulation of Positive_regulation of Il6 1 0.00 0.79 0.19 5.00
114 INT222531 Il6 Positive_regulation of Hpse 1 0.00 0.61 0.18 5.00
115 INT222661 IFNA1 Positive_regulation of Gene_expression of Nos1 1 0.01 0.25 0.18 5.00
116 INT222414 Tlr4 Positive_regulation of Hpse 1 0.00 0.61 0.18 5.00
117 INT222470 Prl Regulation of Gnrh1 1 0.14 0.09 0.18 5.00
118 INT1394 Binding of Prl and LH 3 0.36 0 0.17 5.00
119 INT222443 INCENP Positive_regulation of Localization of Pomc 1 0.00 0.75 0.17 5.00
120 INT222426 Lif Positive_regulation of Localization of Pomc 1 0.02 0.75 0.17 5.00
121 INT222505 Gene_expression of Crh Negative_regulation of Gene_expression of Hpse 1 0.02 0.55 0.17 5.00
122 INT222509 Ghrh Positive_regulation of Localization of Prl 1 0.28 0.23 0.16 5.00
123 INT222430 Il11 Positive_regulation of Localization of Pomc 1 0.01 0.69 0.16 5.00
124 INT222548 Il11 Positive_regulation of Transcription of Pomc 1 0.03 0.7 0.16 5.00
125 INT222420 Tlr4 Positive_regulation of Positive_regulation of Hpse 1 0.00 0.67 0.15 5.00
126 INT39154 Crh Positive_regulation of Avp 2 0.11 0.15 0.14 5.00
127 INT222673 Gnrh1 Negative_regulation of Gnrh1 Positive_regulation of Prl 1 0.08 0.21 0.14 5.00
128 INT222551 Il6 Positive_regulation of Positive_regulation of Hpse 1 0.01 0.5 0.13 5.00
129 INT215034 Gh Regulation of Igf1 1 0.13 0.27 0.13 5.00
130 INT222465 Binding of Calcrl and Rxfp2 1 0.02 0 0.12 5.00
131 INT222546 Mzb1 Positive_regulation of Localization of Prl 1 0.10 0.17 0.12 5.00
132 INT222549 Pomc Positive_regulation of Gnrh1 1 0.13 0 0.12 5.00
133 INT222507 Igf1 Positive_regulation of Localization of Edn3 1 0.05 0 0.11 5.00
134 INT341775 DBT Regulation of Binding of ESR1 1 0.02 0.1 0.11 5.00
135 INT222472 Lep Positive_regulation of Localization of Cartpt 1 0.05 0 0.11 5.00
136 INT222503 Agt Positive_regulation of Localization of Gh1 1 0.02 0.23 0.11 5.00
137 INT222558 Mzb1 Regulation of Localization of Prl 1 0.13 0.14 0.1 5.00
138 INT243468 Binding of SSTR1 and SSTR5 1 0.05 0.99 0.1 5.00
139 INT222501 Cartpt Negative_regulation of Localization of Prl 1 0.08 0 0.1 5.00
140 INT222553 Binding of Sdc1 and Egf 1 0.02 0 0.1 5.00
141 INT243465 Binding of GH1 and GOPC 1 0.02 0.99 0.09 5.00
142 INT222517 Calca Positive_regulation of Localization of Gh1 1 0.03 0 0.09 5.00
143 INT222442 Tlr4 Positive_regulation of Gene_expression of INCENP 1 0.00 0.34 0.09 5.00
144 INT222425 Mif Regulation of Tlr4 1 0.01 0.24 0.09 5.00
145 INT341776 ESR1 Positive_regulation of Gene_expression of SLC6A3 1 0.06 0.08 0.09 5.00
146 INT222483 Trh Regulation of Gene_expression of Gh1 1 0.03 0 0.09 5.00
147 INT222484 Pomc Positive_regulation of Transcription of Prl 1 0.14 0 0.09 5.00
148 INT243466 POU1F1 Regulation of GH1 1 0.11 1.26 0.08 5.00
149 INT222511 Il1a Positive_regulation of Gene_expression of Fst 1 0.01 0.32 0.08 5.00
150 INT1388 Binding of Prl and Gnrh1 3 0.35 0.17 0.08 5.00
151 INT222545 Lep Negative_regulation of Nmb 1 0.04 0.52 0.08 5.00
152 INT8092 Npy Regulation of Localization of Gnrh1 2 0.30 0.08 0.08 5.00
153 INT243464 POU1F1 Regulation of PRL 1 0.28 1.26 0.08 5.00
154 INT222514 Mif Regulation of Localization of Il6 1 0.04 0.23 0.08 5.00
155 INT222506 Gnrh1 Regulation of Localization of Prl 1 0.20 0.16 0.08 5.00
156 INT222662 Il1a Positive_regulation of Gene_expression of INCENP 1 0.00 0.32 0.08 5.00
157 INT222489 Npr2 Positive_regulation of Pde5a 1 0.00 0.16 0.07 5.00
158 INT222466 Gnrh1 Regulation of Prl 1 0.14 1.16 0.07 5.00
159 INT222429 Nps Positive_regulation of Pde5a 1 0.00 0.16 0.07 5.00
160 INT32745 Crh Positive_regulation of Localization of Pomc 2 0.16 0.49 0.07 5.00
161 INT222416 Tlr4 Positive_regulation of Gene_expression of Inhba 1 0.00 0.29 0.06 5.00
162 INT222488 Gal Positive_regulation of Gene_expression of Prl 1 0.05 0.05 0.06 5.00
163 INT222479 Binding of Ramp1 and Rxfp2 1 0.01 0 0.06 5.00
164 INT222431 Tlr4 Positive_regulation of Gene_expression of Fst 1 0.01 0.29 0.06 5.00
165 INT222533 Mzb1 Positive_regulation of Gene_expression of Gh1 1 0.03 0 0.06 5.00
166 INT222478 Binding of Calca and Rxfp2 1 0.02 0 0.06 5.00
167 INT222513 Mzb1 Positive_regulation of Localization of Gh1 1 0.03 0 0.06 5.00
168 INT215036 Gh Positive_regulation of Gene_expression of Trh 1 0.08 1.4 0.06 5.00
169 INT222570 Cnp Positive_regulation of Localization of Gh1 1 0.03 0 0.06 5.00
170 INT222663 Mzb1 Positive_regulation of Localization of VEGFA 1 0.02 0 0.05 5.00
171 INT222463 Inhba Positive_regulation of Gene_expression of Fst 1 0.01 0 0.05 5.00
172 INT222520 Mzb1 Positive_regulation of Gene_expression of Fst 1 0.04 0 0.05 5.00
173 INT222476 Gnrh1 Negative_regulation of Gene_expression of Fst 1 0.04 0 0.05 5.00
174 INT222544 Binding of Ucn and Crh 1 0.02 0 0.05 5.00
175 INT222508 Ghrh Regulation of Localization of LH 1 0.07 0 0.05 5.00
176 INT222487 Trh Negative_regulation of Nmb 1 0.05 0.26 0.05 5.00
177 INT222512 Nppa Positive_regulation of Localization of LH 1 0.02 0 0.05 5.00
178 INT222664 Il6 Positive_regulation of Localization of VEGFA 1 0.01 0 0.05 5.00
179 INT222559 Binding of Ramp3 and Ramp1 1 0.02 0 0.05 5.00
180 INT222485 Binding of Iapp and Ramp1 1 0.09 0 0.05 5.00
181 INT222567 Negative_regulation of Gh1 Negative_regulation of Ghrh 1 0.03 0.19 0.04 5.00
182 INT222498 Ghrh Positive_regulation of Gene_expression of Ghrl 1 0.10 0.19 0.04 5.00
183 INT222417 Ucn Positive_regulation of Localization of Pomc 1 0.01 0 0.04 5.00
184 INT222534 Gnrh1 Positive_regulation of Localization of Lep 1 0.07 0 0.04 5.00
185 INT222497 Negative_regulation of Gh1 Negative_regulation of Ghrl 1 0.01 0.2 0.04 5.00
186 INT222562 Trh Regulation of Localization of LH 1 0.04 0 0.03 5.00
187 INT334918 GNRH1 Positive_regulation of Gene_expression of FSHR 2 0.11 1.27 0.03 5.00
188 INT222468 Nmb Positive_regulation of Localization of Trh 1 0.05 0.28 0.03 5.00
189 INT222532 Anxa1 Negative_regulation of Localization of Gh1 1 0.01 0.14 0.03 5.00
190 INT222469 Binding of Ucn and Crhr2 1 0.00 0 0.03 5.00
191 INT222477 Mzb1 Positive_regulation of Gene_expression of Prl 1 0.10 0.1 0.03 5.00
192 INT222565 Crh Positive_regulation of Transcription of Pomc 1 0.10 0.35 0.03 5.00
193 INT222538 Anxa1 Negative_regulation of Localization of Prl 1 0.04 0.14 0.03 5.00
194 INT246480 Binding of ALB and SHBG 2 0.14 1.45 0.03 5.00
195 INT222564 Mzb1 Regulation of Localization of Gh1 1 0.01 0 0.03 5.00
196 INT222475 Anxa1 Negative_regulation of Localization of LH 1 0.01 0.14 0.03 5.00
197 INT222510 Nmb Positive_regulation of Trh 1 0.05 0.28 0.03 5.00
198 INT222500 Avp Positive_regulation of Transcription of Pomc 1 0.17 0.35 0.03 5.00
199 INT197808 Binding of MEN1 and NME1 1 0.00 1.81 0 5.00
200 INT196948 Hmga2 Positive_regulation of Hdac1 1 0.36 0.23 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Prolactinoma. They are ordered first by their pain relevance and then by number of times they were reported in Prolactinoma. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT528 Gene_expression of Prl 693 0.78 217.18 192.2 100.00
2 INT158 Localization of Prl 2431 0.81 378.96 952.2 100.00
3 INT425 Localization of PRL 455 0.81 189.64 144.8 100.00
4 INT252 Localization of GH1 529 0.80 227.4 122.05 100.00
5 INT1893 Localization of Gh 1041 0.79 340.23 256.58 100.00
6 INT443 Localization of POMC 1020 0.81 284.52 443.17 100.00
7 INT16455 Gene_expression of Drd2 116 0.78 22.71 38.47 100.00
8 INT34777 Localization of IGF1 82 0.80 42.68 8.62 100.00
9 INT132971 Negative_regulation of Localization of IGF1 5 0.42 3.98 1.94 100.00
10 INT223278 Positive_regulation of Binding of TERT 2 0.44 1.35 0 100.00
11 INT8347 Gene_expression of SST 181 0.78 104.59 65.45 99.98
12 INT35467 Gene_expression of DIO2 37 0.65 9.56 12.61 99.98
13 INT173234 Gene_expression of Sst1 2 0.14 0.88 0.63 99.98
14 INT28861 Binding of Gh 61 0.46 25.61 6.38 99.98
15 INT162 Regulation of Prl 794 0.62 165.01 322.24 99.96
16 INT1976 Regulation of Gene_expression of Prl 80 0.62 20.19 36 99.96
17 INT916 Regulation of Localization of PRL 92 0.62 22.98 38.13 99.96
18 INT202259 Transcription of Pttg1 1 0.34 4.13 0.53 99.96
19 INT20176 Transcription of Prl 15 0.72 7.32 2.25 99.96
20 INT86531 Regulation of Transcription of Prl 2 0.44 1.48 0.59 99.96
21 INT156 Negative_regulation of Prl 542 0.59 131.97 192.24 99.92
22 INT7412 Positive_regulation of SST 71 0.70 24.44 29.48 99.92
23 INT1378 Negative_regulation of Regulation of Prl 27 0.43 9.16 9.9 99.92
24 INT107962 Gene_expression of Pttg1 34 0.53 34.05 3.11 99.84
25 INT956 Negative_regulation of PRL 94 0.59 42.72 23.01 99.84
26 INT1579 Gene_expression of PRL 279 0.78 119.2 55.41 99.76
27 INT1512 Binding of Prl 73 0.48 26.22 20.63 99.76
28 INT1578 Negative_regulation of Localization of PRL 52 0.59 20.62 17.18 99.60
29 INT157 Positive_regulation of Localization of Prl 790 0.70 104.54 374.78 99.60
30 INT34977 Gene_expression of Hmga2 11 0.76 12.39 3.07 99.60
31 INT170300 Positive_regulation of Gene_expression of Hmga2 2 0.68 4.51 0.06 99.60
32 INT155 Positive_regulation of Prl 1233 0.70 317.93 457.82 99.52
33 INT197832 Localization of MEN1 1 0.80 11.01 0.63 99.52
34 INT161 Regulation of Localization of Prl 615 0.62 65.37 298.66 99.44
35 INT147607 Binding of TERT 16 0.48 12.36 1.31 99.44
36 INT767 Localization of Gnrhr 565 0.80 106.68 214.57 99.40
37 INT3559 Negative_regulation of Localization of Gnrhr 73 0.58 18.89 26.41 99.40
38 INT202268 Regulation of Gene_expression of Pttg1 3 0.33 3.1 0.34 99.36
39 INT5128 Positive_regulation of Lhb 232 0.69 44.23 71.26 99.36
40 INT1894 Negative_regulation of Localization of Gh 168 0.58 64.12 43.56 99.32
41 INT6021 Binding of PRL 18 0.48 12.55 4.3 99.30
42 INT9682 Positive_regulation of IGF1 238 0.70 120.03 26.36 99.12
43 INT5372 Localization of LHB 55 0.68 9.47 19 99.08
44 INT16015 Negative_regulation of Localization of LHB 10 0.37 2.95 2.9 99.08
45 INT915 Positive_regulation of PRL 342 0.70 141.96 104.31 99.06
46 INT17033 Positive_regulation of Trf 21 0.62 11.76 2.68 98.80
47 INT871 Negative_regulation of Gene_expression of Prl 53 0.58 18.89 17.79 98.68
48 INT17894 Regulation of Myc 10 0.60 5.65 0.93 98.50
49 INT107961 Positive_regulation of Gene_expression of Pttg1 2 0.38 11.69 1.09 98.44
50 INT2296 Positive_regulation of Gene_expression of Prl 137 0.70 36.96 35.39 98.32
51 INT28950 Positive_regulation of Gene_expression of IGF1 99 0.69 46.9 16.47 98.32
52 INT68292 Gene_expression of cab 1 0.15 0.99 0.16 98.08
53 INT246462 Gene_expression of SCG5 3 0.65 0.78 0.17 97.90
54 INT64689 Positive_regulation of Gene_expression of Fgf2 30 0.70 12.05 6.2 97.80
55 INT67195 Negative_regulation of Gene_expression of SST 7 0.42 6.98 4.88 97.78
56 INT531 Gene_expression of GH1 376 0.75 193.45 46.24 97.56
57 INT847 Regulation of Lhb 131 0.61 22.08 46.54 97.40
58 INT10369 Positive_regulation of Spic 4 0.03 1.99 1.54 97.40
59 INT48144 Gene_expression of Fgf2 117 0.78 43 20.48 97.28
60 INT159 Negative_regulation of Localization of Prl 416 0.59 55.34 171.8 97.28
61 INT253 Regulation of PRL 184 0.62 47.27 65.79 97.26
62 INT921 Regulation of GH1 172 0.60 52.88 51.04 97.10
63 INT62360 Positive_regulation of PTHLH 31 0.70 28.23 3.46 97.00
64 INT3230 Negative_regulation of Negative_regulation of Prl 9 0.43 1.85 4.41 96.96
65 INT202264 Positive_regulation of Pttg1 8 0.45 8.03 1.04 96.88
66 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 96.72
67 INT4345 Gene_expression of Gtf3a 157 0.67 80.75 48.47 96.72
68 INT276149 Localization of SCG5 3 0.78 0.56 0.13 96.72
69 INT36798 Gene_expression of Mki67 178 0.77 132 8.24 96.52
70 INT1498 Gene_expression of Gh 521 0.75 220.84 81.16 96.36
71 INT987 Localization of TRH 37 0.78 10.53 11.1 96.20
72 INT914 Positive_regulation of GH1 292 0.69 100.7 84.91 95.72
73 INT957 Positive_regulation of GHRH 136 0.70 36.84 40.52 95.72
74 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07 95.68
75 INT67097 Gene_expression of MIB1 20 0.75 21.06 1.03 95.60
76 INT619 Positive_regulation of Positive_regulation of Prl 116 0.70 22.69 45.06 95.52
77 INT90 Localization of Gast 400 0.81 137.67 113 95.24
78 INT12569 Localization of Oprd1 94 0.81 23.81 104.56 95.24
79 INT2066 Localization of Agt 56 0.80 9.95 16.25 95.24
80 INT5099 Localization of Gal 46 0.81 10.66 18.93 95.24
81 INT287 Localization of Cck 518 0.81 86.84 364.04 95.24
82 INT248 Positive_regulation of Localization of GH1 137 0.69 49.25 32.92 95.18
83 INT918 Positive_regulation of Localization of PRL 90 0.70 23.97 40.3 95.04
84 INT5127 Localization of Lhb 488 0.80 50.48 162.66 94.20
85 INT6299 Regulation of Localization of Lhb 104 0.61 8.98 48.79 94.20
86 INT397 Localization of SST 232 0.81 58.05 101.19 94.20
87 INT2005 Positive_regulation of Gene_expression of PRL 55 0.70 21.4 13.44 94.16
88 INT249 Localization of GHRH 215 0.80 78.02 51.87 94.16
89 INT984 Positive_regulation of Localization of GHRH 58 0.70 12.66 16.51 94.16
90 INT1793 Localization of CGA 379 0.81 67.38 114.69 94.00
91 INT1794 Regulation of Localization of CGA 136 0.57 13.39 59.07 94.00
92 INT189948 Gene_expression of Pttg1 106 0.76 104.68 1.41 93.96
93 INT16621 Negative_regulation of Esr1 20 0.54 8.2 4.84 93.60
94 INT7035 Regulation of CGA 87 0.45 29.04 28.45 93.60
95 INT467 Gene_expression of POMC 1048 0.78 332.8 394.16 93.56
96 INT1646 Negative_regulation of Localization of FSHR 17 0.58 7.36 3.46 93.44
97 INT912 Localization of FSHR 91 0.79 23.61 15.58 93.44
98 INT16220 Negative_regulation of Regulation of Gh 13 0.42 3.59 4.33 93.36
99 INT132972 Gene_expression of HADH 3 0.65 4.75 1.13 93.04
100 INT21067 Regulation of Regulation of PRL 11 0.60 2 5.31 92.92
101 INT156404 Negative_regulation of Pttg1 2 0.23 4.06 0.62 92.88
102 INT920 Localization of PLOD1 223 0.81 42.25 78.7 92.80
103 INT1642 Negative_regulation of Localization of PLOD1 40 0.58 10.67 17.95 92.80
104 INT4487 Positive_regulation of Positive_regulation of PRL 27 0.70 8.06 8.09 92.00
105 INT212025 Localization of RAD51D 1 0.08 1.29 0 91.20
106 INT68973 Positive_regulation of Mmp9 89 0.52 58.56 30.04 90.92
107 INT68976 Positive_regulation of Gene_expression of Mmp9 34 0.42 28.21 11.28 90.92
108 INT738 Regulation of POMC 459 0.62 111.19 243.74 90.88
109 INT68975 Gene_expression of Mmp9 111 0.78 79.57 38.55 90.52
110 INT255 Regulation of Localization of GH1 89 0.62 18.71 35.3 90.44
111 INT196923 Binding of Hmga2 1 0.47 2.5 0 90.32
112 INT15459 Gene_expression of TRH 17 0.78 4.89 8.17 90.20
113 INT1644 Regulation of FSHR 77 0.55 15.62 21.49 90.16
114 INT25047 Positive_regulation of Regulation of FSHR 3 0.31 0.92 0.29 90.16
115 INT65058 Binding of Nfkb1 36 0.45 19.87 10.02 89.40
116 INT300622 Binding of Jund 1 0.04 1.57 0 89.40
117 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 89.20
118 INT4342 Localization of ALPP 27 0.69 15.19 5.32 89.04
119 INT239093 Gene_expression of PTTG1 84 0.65 83.94 1.87 88.72
120 INT3933 Positive_regulation of PLOD1 128 0.70 30.76 42.03 88.56
121 INT7395 Localization of GNRH1 399 0.81 62.88 117.68 88.52
122 INT1377 Positive_regulation of Trh 172 0.70 40.55 69.83 88.36
123 INT202260 Regulation of Transcription of Pttg1 1 0.21 1.13 0.16 88.28
124 INT7113 Negative_regulation of Localization of CGA 71 0.51 17.7 23.42 88.28
125 INT20174 Positive_regulation of Transcription of Prl 2 0.69 0.63 0.14 87.84
126 INT1530 Regulation of Gh 382 0.61 115.96 112.47 87.76
127 INT13501 Binding of Drd2 65 0.48 23.76 35.6 87.68
128 INT36007 Negative_regulation of Binding of Drd2 7 0.57 3.22 4.36 87.68
129 INT5711 Positive_regulation of Localization of Lhb 90 0.70 10.92 36.76 87.20
130 INT28951 Negative_regulation of IGF1 133 0.59 75.77 18.9 86.96
131 INT28952 Negative_regulation of Gene_expression of IGF1 75 0.58 41.11 12.32 86.96
132 INT2640 Gene_expression of Pomc 424 0.78 120.72 155.37 86.92
133 INT2614 Gene_expression of CGA 187 0.78 105.89 24.77 86.48
134 INT213741 Gene_expression of Kdr 60 0.75 44.24 5.35 86.08
135 INT140091 Gene_expression of Ctgf 26 0.78 14.21 2.39 86.00
136 INT22068 Binding of CALCRL 53 0.41 6.14 17.32 85.88
137 INT20080 Localization of PRLR 2 0.03 0.42 1.12 85.68
138 INT10842 Transcription of Gh 18 0.64 2.94 4.13 85.64
139 INT45719 Positive_regulation of Transcription of Gh 5 0.47 0.68 1.66 85.64
140 INT10841 Positive_regulation of Gene_expression of Gh 101 0.59 45.39 16.96 85.28
141 INT40502 Localization of NOM1 1 0.05 0.33 0.33 84.56
142 INT151907 Binding of Ecm1 6 0.11 2.48 0.83 82.48
143 INT62359 Negative_regulation of Positive_regulation of PTHLH 3 0.42 2.71 0.18 80.80
144 INT13363 Binding of NFKBIL1 23 0.08 2.65 13.09 80.76
145 INT5710 Negative_regulation of Localization of Lhb 146 0.57 20.51 58.33 79.88
146 INT20082 Positive_regulation of PRLR 6 0.29 4.27 3.03 78.84
147 INT1197 Negative_regulation of Localization of POMC 109 0.59 28.29 48.02 78.32
148 INT16235 Positive_regulation of CGB 27 0.70 15.71 4.06 77.68
149 INT160 Regulation of Positive_regulation of Prl 37 0.62 7.56 20.09 77.44
150 INT66367 Gene_expression of Gsk3b 16 0.45 9.75 3.07 77.20
151 INT955 Gene_expression of GHRH 126 0.78 59.91 20.74 76.44
152 INT954 Positive_regulation of Gene_expression of GHRH 18 0.50 7.6 1.63 76.44
153 INT1577 Negative_regulation of Gene_expression of PRL 24 0.59 7.7 3.15 76.32
154 INT7970 Gene_expression of PLOD1 120 0.71 44.42 15.54 75.28
155 INT4145 Gene_expression of FSHR 124 0.77 44.98 13.04 75.28
156 INT69781 Negative_regulation of FGF2 22 0.42 17.25 4.24 75.28
157 INT97900 Negative_regulation of Gene_expression of FGF2 9 0.57 8.37 1.48 75.28
158 INT202262 Negative_regulation of Gene_expression of Pttg1 2 0.25 1.57 0.12 75.28
159 INT10785 Gene_expression of Prl 35 0.78 20.64 6.7 75.00
160 INT11554 Negative_regulation of CSF2 129 0.59 108.55 29.44 75.00
161 INT5344 Negative_regulation of BRD2 12 0.56 4.71 1.89 75.00
162 INT2262 Negative_regulation of Lhb 142 0.59 25.47 44.81 74.28
163 INT179118 Gene_expression of Nrp1 2 0.43 1.37 0.04 73.04
164 INT300623 Positive_regulation of Men1 1 0.35 10.65 0.57 72.56
165 INT246502 Negative_regulation of Men1 2 0.30 8.9 0.33 72.56
166 INT222655 Binding of Sdc1 3 0.05 0.64 0.12 71.88
167 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 71.36
168 INT26795 Gene_expression of Mtpn 44 0.62 27.66 8.62 71.36
169 INT24670 Gene_expression of FGF2 121 0.78 85.64 15.12 71.28
170 INT43721 Gene_expression of Vegfa 49 0.77 36.18 6.63 70.72
171 INT339 Regulation of Trh 156 0.62 39.27 83.55 70.04
172 INT196913 Regulation of Kras 3 0.10 3.81 0.28 70.04
173 INT196919 Regulation of Braf 3 0.32 6.14 2.55 69.84
174 INT57971 Regulation of Rb1 5 0.41 2.36 1.66 69.60
175 INT27269 Localization of Ghrh 29 0.76 15.42 2.19 68.04
176 INT1511 Negative_regulation of Binding of Prl 7 0.59 1.64 2.19 67.20
177 INT169930 Binding of Rb1 15 0.43 5.91 0.16 66.76
178 INT17701 Gene_expression of PTHLH 103 0.78 64.23 8.85 66.40
179 INT32760 Regulation of Gene_expression of PTHLH 4 0.51 6.32 1 66.40
180 INT913 Regulation of Localization of PLOD1 71 0.62 8.64 32.72 65.88
181 INT212022 Gene_expression of RAD51D 4 0.27 0.81 0 65.44
182 INT9683 Binding of GH1 57 0.47 21.14 5.99 65.16
183 INT222618 Gene_expression of Prok1 1 0.05 0.4 0 64.96
184 INT114824 Binding of PTHLH 12 0.42 9.5 0.9 64.76
185 INT26538 Positive_regulation of FSHR 103 0.69 30.95 15.33 64.32
186 INT189946 Positive_regulation of Gene_expression of Pttg1 14 0.68 23.72 0.38 60.88
187 INT6108 Gene_expression of Npy 292 0.78 110.65 148.21 57.24
188 INT196920 Transcription of E2f1 4 0.68 2.65 0.21 56.64
189 INT985 Negative_regulation of GH1 213 0.57 89.53 32.39 56.20
190 INT169929 Negative_regulation of E2f1 12 0.41 3.03 0.04 56.16
191 INT115423 Gene_expression of Men1 4 0.47 14.08 0.64 55.56
192 INT202269 Regulation of Pttg1 3 0.33 2.47 0.27 54.64
193 INT202266 Binding of Pttg1 2 0.29 1.37 0.08 53.68
194 INT196937 Positive_regulation of Hmga2 3 0.68 2.47 0.28 53.00
195 INT170302 Regulation of Hmga2 2 0.44 0.94 0.06 53.00
196 INT16303 Negative_regulation of Localization of GH1 89 0.59 37.31 22.15 52.36
197 INT202261 Protein_catabolism of Pttg1 1 0.54 1.52 0.1 50.76
198 INT202263 Regulation of Protein_catabolism of Pttg1 1 0.15 0.96 0.1 50.72
199 INT202265 Positive_regulation of Protein_catabolism of Pttg1 1 0.38 0.95 0.1 50.72
200 INT739 Negative_regulation of POMC 358 0.59 102.28 166.77 50.00
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