D:Prolapse

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pChart

Disease Term
Synonyms Prolapses
Documents 952
Hot Single Events 33
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Prolapse. They are ordered first by their relevance to Prolapse and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT180200 Binding of BCAR1 and MMVP1 1 0.11 8.57 0.08 79.96
2 INT273772 BCKDHA Positive_regulation of Positive_regulation of NARFL 1 0.03 1.21 0 10.56
3 INT291556 Binding of ESR1 and Sec22b 2 0.00 0.86 0.5 5.00
4 INT314070 Gopc Negative_regulation of Il6 1 0.10 0.63 0.21 5.00
5 INT314076 Peo1 Negative_regulation of Il6 1 0.35 0.62 0.21 5.00
6 INT314078 Peo1 Negative_regulation of Stat1 1 0.31 1.23 0.17 5.00
7 INT314069 Gopc Negative_regulation of Stat1 1 0.14 0.95 0.15 5.00
8 INT314075 Peo1 Regulation of Positive_regulation of Stat1 1 0.37 0.43 0.08 5.00
9 INT314064 Gopc Negative_regulation of Positive_regulation of Stat1 1 0.12 0.57 0.08 5.00
10 INT314072 Peo1 Negative_regulation of Cxcl10 1 0.24 0.39 0.07 5.00
11 INT314068 Gopc Negative_regulation of Cxcl10 1 0.11 0.39 0.07 5.00
12 INT310674 Positive_regulation of Binding of ARSB and ELF3 1 0.07 2.46 0.05 5.00
13 INT310675 Binding of ARSB and ELF3 1 0.06 2.4 0.05 5.00
14 INT314073 Peo1 Negative_regulation of Nos2 1 0.11 0.32 0.04 5.00
15 INT314074 Peo1 Regulation of Cxcl10 1 0.25 0.21 0.03 5.00
16 INT314067 Stat1 Regulation of Nos2 1 0.13 0.2 0.03 5.00
17 INT314065 Peo1 Regulation of Nos2 1 0.18 0.2 0.03 5.00
18 INT314077 Peo1 Negative_regulation of Positive_regulation of Stat1 1 0.31 0.33 0.03 5.00
19 INT314071 Stat1 Regulation of Cxcl10 1 0.26 0.2 0.03 5.00
20 INT235649 TP73 Regulation of EFNA1 1 0.09 0.97 0 5.00
21 INT235645 TP53 Regulation of EPHA2 1 0.10 0.97 0 5.00
22 INT235648 Binding of EFNA1 and EPHA2 1 0.23 1.3 0 5.00
23 INT255557 Binding of TRNV and CD177 1 0.05 0.89 0 5.00
24 INT235647 TP63 Regulation of EPHA2 1 0.15 0.97 0 5.00
25 INT287088 Binding of EEC1 and Vamp3 1 0.09 1.02 0 5.00
26 INT235650 TP53 Regulation of EFNA1 1 0.06 0.97 0 5.00
27 INT235646 TP63 Regulation of EFNA1 1 0.09 0.97 0 5.00
28 INT235651 TP73 Regulation of EPHA2 1 0.15 0.98 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Prolapse. They are ordered first by their pain relevance and then by number of times they were reported in Prolapse. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT198852 Positive_regulation of Ucp1 8 0.61 8 1.53 100.00
2 INT78719 Binding of Ucp1 8 0.41 8.93 4.5 100.00
3 INT281803 Regulation of Ucp1 4 0.57 4.03 0.05 100.00
4 INT176892 Binding of MR1 36 0.32 15.55 2.58 100.00
5 INT19047 Localization of SLC25A4 5 0.73 2.73 0.57 99.84
6 INT134482 Negative_regulation of MMVP1 1 0.00 0.98 0.09 99.84
7 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 99.14
8 INT95500 Positive_regulation of Nefh 14 0.50 4.45 12.26 99.02
9 INT7125 Gene_expression of PLA2G2A 47 0.78 42.12 7.83 98.64
10 INT64864 Gene_expression of PLA2G4A 18 0.77 10.45 4.09 98.64
11 INT253294 Positive_regulation of Oca2 5 0.11 1.62 0.13 98.64
12 INT180201 Regulation of MMVP1 1 0.08 1.57 0.11 98.52
13 INT255559 Binding of TRNV 1 0.11 2.7 0.09 97.92
14 INT328203 Positive_regulation of RBL1 1 0.12 2.62 1.12 97.20
15 INT637 Positive_regulation of MRAP 23 0.67 21.13 9.97 96.16
16 INT3777 Positive_regulation of NARFL 256 0.56 302.43 25.74 95.36
17 INT899 Gene_expression of F13A1 122 0.70 78.02 16.26 94.88
18 INT58192 Positive_regulation of MRI1 86 0.61 53.81 24.68 92.76
19 INT78773 Regulation of PLA2G2A 11 0.61 9.76 1.91 91.72
20 INT78775 Regulation of PLA2G4A 4 0.25 1.45 0.55 91.32
21 INT9973 Binding of MMVP1 14 0.48 22.66 1.79 91.16
22 INT168446 Gene_expression of Prep 25 0.64 15.17 5.94 91.12
23 INT227524 Positive_regulation of Gene_expression of Prep 13 0.48 7.69 3.28 91.12
24 INT178962 Gene_expression of Oca2 15 0.19 5.15 0.38 87.68
25 INT47029 Protein_catabolism of MMVP1 1 0.17 1.34 0.09 87.20
26 INT9660 Regulation of TNF 363 0.62 312.94 139.99 87.06
27 INT227424 Binding of Prep 6 0.35 2.61 1.39 85.36
28 INT127849 Binding of LOC246267 1 0.19 0.94 0.17 83.48
29 INT314059 Negative_regulation of Peo1 1 0.31 2.22 0.44 83.12
30 INT78774 Gene_expression of PLA2G6 15 0.61 8.39 1.56 82.88
31 INT639 Regulation of LAMC2 8 0.44 4.68 2.92 81.44
32 INT252951 Localization of Oca2 2 0.17 1.53 0.23 81.04
33 INT178830 Negative_regulation of MR1 16 0.50 7.63 0.44 80.32
34 INT255561 Positive_regulation of Gene_expression of TRNV 1 0.12 1.3 0.1 79.00
35 INT255562 Positive_regulation of TRNV 1 0.12 2.03 0.1 79.00
36 INT255560 Gene_expression of TRNV 1 0.16 1.29 0.1 77.36
37 INT11439 Positive_regulation of Csf2 105 0.69 62.63 37.77 77.20
38 INT170855 Negative_regulation of GOPC 188 0.38 70.92 15.41 76.80
39 INT968 Gene_expression of MMVP1 2 0.52 2.3 0.27 76.76
40 INT61340 Regulation of Prep 7 0.50 6.13 2.31 75.60
41 INT13696 Regulation of COL3A1 2 0.45 2.97 0.95 75.20
42 INT12082 Localization of IL6 365 0.81 241.78 105.78 75.16
43 INT105052 Transcription of Atp7a 1 0.44 1.91 0.69 75.00
44 INT44662 Regulation of Atp7a 2 0.30 1.78 1.04 75.00
45 INT46293 Negative_regulation of Atp7a 2 0.35 1.18 0.7 75.00
46 INT105051 Negative_regulation of Transcription of Atp7a 1 0.35 1.02 0.36 75.00
47 INT6210 Binding of Nppa 39 0.47 14.35 7.21 74.40
48 INT176646 Binding of Bpifa2 15 0.30 7.65 0.5 73.20
49 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 72.64
50 INT1878 Binding of HLA-B 440 0.48 321.16 127.36 70.80
51 INT22454 Regulation of Crp 213 0.62 160.67 49.24 70.72
52 INT305227 Negative_regulation of Gene_expression of Prep 2 0.11 1.42 0.1 70.44
53 INT5623 Positive_regulation of Nppa 174 0.70 69.96 52.33 70.40
54 INT27753 Positive_regulation of MMVP1 5 0.43 7.1 0.74 69.40
55 INT15516 Gene_expression of Crp 711 0.77 615.33 173.09 66.92
56 INT49215 Binding of Hal 3 0.40 1.43 0.8 62.24
57 INT216691 Gene_expression of CASK 1 0.06 1.32 0.05 62.08
58 INT3404 Binding of BCAR1 10 0.33 7.97 1.33 61.96
59 INT112941 Phosphorylation of SLC3A2 1 0.01 0.29 0.08 59.80
60 INT5622 Gene_expression of Nppa 101 0.78 49.46 25.31 58.72
61 INT29566 Positive_regulation of Bpifa2 22 0.46 8.04 1.62 57.48
62 INT235660 Gene_expression of EPHA2 27 0.75 23.46 0.4 57.28
63 INT235659 Gene_expression of EFNA1 1 0.45 22.92 0.06 57.28
64 INT33892 Positive_regulation of CD177 5 0.23 2.96 1.84 56.64
65 INT272274 Localization of NARFL 24 0.60 27.55 1.18 55.40
66 INT72947 Binding of CHM 9 0.42 5.86 0.06 54.96
67 INT176888 Positive_regulation of MR1 29 0.67 11.68 1.71 51.56
68 INT328202 Gene_expression of RBL1 1 0.13 1.84 1.37 50.12
69 INT173639 Positive_regulation of INCENP 40 0.14 20.97 6.7 48.64
70 INT4021 Positive_regulation of PLA2G1B 35 0.70 23.27 8.2 48.48
71 INT253219 Binding of Mapk1ip1 1 0.32 0.28 0 46.92
72 INT253218 Negative_regulation of Binding of Mapk1ip1 1 0.37 0.28 0 46.92
73 INT198101 Negative_regulation of AVSD1 2 0.19 0.89 0.08 43.92
74 INT177584 Gene_expression of MR1 80 0.58 46.48 5.48 42.16
75 INT177593 Positive_regulation of Gene_expression of MR1 17 0.43 9.36 1.13 42.16
76 INT17598 Positive_regulation of CFHR1 11 0.50 2.6 2.38 41.20
77 INT95495 Phosphorylation of Nefh 13 0.82 7.36 12.1 39.92
78 INT17237 Regulation of Esr1 74 0.43 49.09 17.25 38.92
79 INT95006 Regulation of Localization of Crp 3 0.60 0.82 0.73 35.76
80 INT3810 Regulation of CFHR1 7 0.38 1.19 2.13 34.00
81 INT161960 Regulation of lg 5 0.26 1.18 2.84 33.36
82 INT310680 Gene_expression of ARSB 1 0.64 6.28 0.12 32.72
83 INT198102 Gene_expression of AVSD1 2 0.30 0.71 0.07 31.68
84 INT265000 Positive_regulation of MUP 1 0.07 0.24 0 31.12
85 INT38056 Localization of Crp 71 0.78 53.14 17.03 30.96
86 INT1981 Negative_regulation of NARFL 219 0.47 223.48 16.41 30.80
87 INT99965 Positive_regulation of Negative_regulation of NARFL 6 0.40 4.5 0.04 30.80
88 INT246299 Negative_regulation of RGS1 1 0.01 0.85 0.81 30.32
89 INT5374 Gene_expression of Esr1 412 0.77 263.89 67.34 26.48
90 INT9094 Gene_expression of COL7A1 277 0.77 143.42 38.73 23.08
91 INT272275 Regulation of Positive_regulation of NARFL 8 0.36 16.68 0.86 22.96
92 INT4420 Positive_regulation of GOT1 103 0.64 88.4 18.38 20.16
93 INT1982 Regulation of NARFL 119 0.49 116.2 14.35 20.04
94 INT117204 Gene_expression of Tcm 39 0.58 10.58 4.88 19.56
95 INT28592 Binding of Dbt 2 0.29 0.34 0.21 19.36
96 INT16166 Positive_regulation of DMD 348 0.67 133.22 15.06 17.52
97 INT3361 Positive_regulation of Esr1 273 0.69 208.53 44.81 17.40
98 INT3776 Positive_regulation of Regulation of NARFL 2 0.37 2.44 0.93 16.36
99 INT39369 Binding of NARFL 14 0.29 16.7 0.93 15.44
100 INT86411 Negative_regulation of Negative_regulation of TNF 24 0.42 17.6 7.89 13.60
101 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 12.88
102 INT272273 Gene_expression of NARFL 89 0.54 121.19 4.47 10.40
103 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
104 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
105 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
106 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
107 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 5.00
108 INT16868 Gene_expression of Il6 807 0.78 499.48 256.57 5.00
109 INT6406 Binding of Oprm1 280 0.48 40.54 226.26 5.00
110 INT6481 Binding of TNF 624 0.48 510.2 214.82 5.00
111 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 5.00
112 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 5.00
113 INT1047 Negative_regulation of LH 314 0.59 53.71 135.89 5.00
114 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61 5.00
115 INT27096 Positive_regulation of Nfkb1 325 0.70 195.11 109.06 5.00
116 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
117 INT82448 Gene_expression of S100a8 246 0.77 236.72 84.02 5.00
118 INT9236 Regulation of Gene_expression of TNF 204 0.62 162.66 72.99 5.00
119 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64 5.00
120 INT9664 Binding of LBP 127 0.48 94.9 63.42 5.00
121 INT2056 Negative_regulation of Gnrh1 175 0.59 33.43 63.32 5.00
122 INT1951 Positive_regulation of Tlr4 345 0.70 176.99 62.42 5.00
123 INT1759 Gene_expression of TIMP1 267 0.77 133.87 59.29 5.00
124 INT169926 Positive_regulation of Gopc 416 0.46 157.8 58.67 5.00
125 INT19775 Localization of Il1 183 0.78 145.5 50.91 5.00
126 INT2774 Binding of Crp 241 0.48 195.89 44.39 5.00
127 INT85943 Negative_regulation of Nos2 161 0.59 108.56 42.65 5.00
128 INT170054 Negative_regulation of Gopc 280 0.38 117.89 42.4 5.00
129 INT11939 Negative_regulation of Il6 138 0.59 87.46 41.24 5.00
130 INT97596 Localization of S100a8 94 0.78 90.69 40.41 5.00
131 INT52732 Negative_regulation of CRP 169 0.59 138.47 40.33 5.00
132 INT9239 Regulation of Gene_expression of IL6 106 0.61 75.24 36.53 5.00
133 INT104392 Gene_expression of Cxcl10 113 0.75 106.86 34.12 5.00
134 INT719 Negative_regulation of SGCG 96 0.57 47.91 30.22 5.00
135 INT724 Negative_regulation of Alb 151 0.59 93.57 29.65 5.00
136 INT37296 Binding of Esr1 117 0.43 62.51 27.33 5.00
137 INT21687 Positive_regulation of ras 143 0.58 97.34 27.31 5.00
138 INT78251 Positive_regulation of LBP 38 0.69 39.98 26.73 5.00
139 INT20462 Binding of ESR1 210 0.44 102.7 26.34 5.00
140 INT9088 Negative_regulation of LBP 48 0.58 33.06 25.89 5.00
141 INT8205 Negative_regulation of Nppa 77 0.59 26.43 25.72 5.00
142 INT58288 Positive_regulation of Gene_expression of Crp 83 0.61 82.23 23.7 5.00
143 INT9292 Positive_regulation of SGCG 93 0.67 35.13 23.48 5.00
144 INT1221 Regulation of SGCG 65 0.60 24.21 22.94 5.00
145 INT39914 Negative_regulation of Cyp1a2 44 0.58 10.04 22 5.00
146 INT8075 Localization of Crh 64 0.81 25.41 19.45 5.00
147 INT9656 Regulation of Gene_expression of Il6 57 0.62 33.3 17.71 5.00
148 INT145097 Negative_regulation of Pain1 16 0.22 19.11 16.82 5.00
149 INT19929 Negative_regulation of Positive_regulation of TNF 52 0.59 38.16 16.51 5.00
150 INT43906 Regulation of Tlr4 71 0.53 35.18 15.49 5.00
151 INT59929 Negative_regulation of CYP2C9 60 0.59 16.33 15.39 5.00
152 INT170335 Gene_expression of INCENP 176 0.54 91.62 15.31 5.00
153 INT16167 Negative_regulation of DMD 186 0.57 108.71 15.25 5.00
154 INT12087 Regulation of Localization of TNF 44 0.62 28.71 15.17 5.00
155 INT73916 Gene_expression of Esr1 58 0.77 26.59 15.15 5.00
156 INT129584 Positive_regulation of Stat3 97 0.68 87.07 14.86 5.00
157 INT70265 Regulation of MRI1 42 0.39 30.95 14.18 5.00
158 INT83950 Gene_expression of Cxcr1 31 0.59 27.76 13.91 5.00
159 INT16919 Gene_expression of IL36RN 48 0.48 32.78 13.83 5.00
160 INT152729 Negative_regulation of Gene_expression of S100a8 33 0.42 32.25 13.64 5.00
161 INT78472 Gene_expression of CDKN2A 223 0.78 173.76 13.61 5.00
162 INT2038 Localization of Esr1 104 0.79 40.12 13.27 5.00
163 INT89404 Regulation of Negative_regulation of TNF 30 0.45 24.47 12.71 5.00
164 INT79545 Positive_regulation of Gene_expression of ESR1 82 0.64 39.42 12.18 5.00
165 INT8629 Positive_regulation of COL7A1 72 0.69 40.66 12.09 5.00
166 INT32203 Negative_regulation of Crp 48 0.58 32.77 11.89 5.00
167 INT2160 Negative_regulation of Negative_regulation of LH 22 0.58 4.58 11.53 5.00
168 INT51265 Phosphorylation of TNF 32 0.81 25.33 10.75 5.00
169 INT178306 Negative_regulation of Gene_expression of Gopc 71 0.37 26.43 9.74 5.00
170 INT80420 Gene_expression of IFI27 145 0.78 63.61 8.83 5.00
171 INT104394 Positive_regulation of Gene_expression of Cxcl10 28 0.65 25.64 8.79 5.00
172 INT32624 Regulation of LBP 15 0.60 11.48 8.71 5.00
173 INT15687 Regulation of ESR1 91 0.60 40.42 7.95 5.00
174 INT5164 Negative_regulation of Ldlr 83 0.58 55.01 7.87 5.00
175 INT182440 Gene_expression of CCNE2 39 0.53 22.07 7.44 5.00
176 INT67822 Binding of SERPINH1 17 0.36 19.05 7.24 5.00
177 INT138922 Positive_regulation of Stat1 57 0.69 28.35 7.2 5.00
178 INT10513 Gene_expression of Plat 44 0.76 19.49 7.17 5.00
179 INT186142 Gene_expression of Ghrh 45 0.66 34.04 6.94 5.00
180 INT99782 Negative_regulation of Cxcl10 21 0.55 18.4 6.5 5.00
181 INT13683 Regulation of Ugt1a6 9 0.28 2.5 6.33 5.00
182 INT38595 Localization of BCAR1 8 0.73 2.9 6.25 5.00
183 INT163756 Phosphorylation of Stat1 45 0.82 14.51 6.11 5.00
184 INT138915 Gene_expression of Stat1 144 0.77 69.53 5.85 5.00
185 INT188844 Gene_expression of AES 44 0.58 33.94 5.85 5.00
186 INT10147 Gene_expression of Serpinc1 28 0.76 17.73 5.77 5.00
187 INT54602 Regulation of MCS 22 0.24 10.41 5.75 5.00
188 INT11622 Gene_expression of Coc 26 0.57 10.56 5.52 5.00
189 INT43997 Positive_regulation of Gene_expression of Esr1 57 0.51 36.66 5.51 5.00
190 INT65135 Binding of CYP2C19 17 0.48 1.82 5.2 5.00
191 INT230829 Localization of Cyp2d4 3 0.63 0.61 5.18 5.00
192 INT201130 Localization of AES 31 0.63 25.45 5.12 5.00
193 INT21747 Localization of crf 8 0.47 5.32 5.06 5.00
194 INT10504 Localization of Pla2g1b 18 0.65 8.19 5.05 5.00
195 INT2144 Localization of COL7A1 36 0.74 20.92 4.67 5.00
196 INT81688 Binding of ras 32 0.41 30.13 4.02 5.00
197 INT154867 Gene_expression of CECR 28 0.57 6.97 3.72 5.00
198 INT20461 Binding of Esr1 34 0.48 9.58 3.66 5.00
199 INT16165 Regulation of DMD 114 0.60 35.13 3.64 5.00
200 INT173878 Gene_expression of ACAN 32 0.75 9.35 3.55 5.00
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