D:Proliferative Vitreoretinopathy

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Disease Term
Synonyms Proliferative Vitreoretinopathies, Vitreoretinopathies Proliferative
Documents 36
Hot Single Events 35
Hot Interactions 5

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Proliferative Vitreoretinopathy. They are ordered first by their relevance to Proliferative Vitreoretinopathy and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT321967 Binding of PDR and PVR 1 0.01 2.32 0 100.00
2 INT251347 Binding of Bmpr2 and Limk1 1 0.18 1.51 0.16 90.48
3 INT19922 Binding of F13A1 and Plat 1 0.01 0.46 0.1 89.44
4 INT251349 Ifnar1 Positive_regulation of Rock1 1 0.01 1.27 0.16 82.48
5 INT251348 Ifnar1 Positive_regulation of Limk2 1 0.01 1.12 0.11 82.48
6 INT256985 Binding of Dlg1 and Cd81 1 0.39 0.2 0.17 45.52
7 INT288026 PROC Positive_regulation of Gene_expression of VEGFA 1 0.01 0.5 0.15 31.92
8 INT321968 Rock1 Positive_regulation of EZR 1 0.42 1.02 0 28.84
9 INT321969 Negative_regulation of Rock1 Negative_regulation of VEGFA 1 0.03 0.65 0 21.36
10 INT259556 PLEK Negative_regulation of Gene_expression of VEGFA 1 0.46 2.15 0.73 5.00
11 INT259557 PLEK Negative_regulation of Positive_regulation of VEGFA 1 0.46 2.15 0.73 5.00
12 INT215789 Fig4 Positive_regulation of Localization of P2rx7 1 0.03 0.53 0.29 5.00
13 INT216911 Positive_regulation of P2rx7 Positive_regulation of Localization of Plg 1 0.02 0.13 0.23 5.00
14 INT256987 Binding of Cd81 and Slc9a3r1 1 0.43 0.06 0.17 5.00
15 INT228453 Igf1 Positive_regulation of Prkca 2 0.12 1.17 0.12 5.00
16 INT321965 Rock1 Positive_regulation of Nos3 1 0.28 1.99 0.12 5.00
17 INT295866 Dss1 Positive_regulation of PSS 1 0.01 0.07 0.05 5.00
18 INT256984 Binding of Cd81 and Cd19 1 0.18 0.36 0.05 5.00
19 INT256990 Binding of Cd81 and Cr2 1 0.18 0.36 0.05 5.00
20 INT295854 Srpk2 Regulation of Localization of Srsf1 1 0.21 0 0.04 5.00
21 INT288025 VEGFA Regulation of IL6 1 0.36 0.26 0.03 5.00
22 INT288027 VEGFA Regulation of CCL2 1 0.44 0.26 0.03 5.00
23 INT288028 VEGFA Regulation of IL8 1 0.36 0.26 0.03 5.00
24 INT295867 Srsf1 Regulation of VEGFA 1 0.10 0 0.03 5.00
25 INT295858 Prkca Positive_regulation of Gtf3a 1 0.00 0 0 5.00
26 INT295868 Igf1 Positive_regulation of VEGFA 1 0.16 0.19 0 5.00
27 INT256997 Binding of RLBP1 and Slc9a3r1 1 0.44 0 0 5.00
28 INT256982 Binding of Cd81 and Rpe 1 0.13 0 0 5.00
29 INT256988 Binding of Dlg1 and Rpe 1 0.06 0 0 5.00
30 INT337915 Tgfbr1 Positive_regulation of Negative_regulation of Smad2 1 0.05 0.15 0 5.00
31 INT337916 sb Negative_regulation of Ctgf 1 0.00 0.13 0 5.00
32 INT295857 Igf1 Regulation of Localization of Srsf1 1 0.50 0 0 5.00
33 INT256991 Binding of Cr2 and Cd19 1 0.05 0.18 0 5.00
34 INT295869 Binding of VEGFA and Srsf1 1 0.17 0 0 5.00
35 INT256979 Binding of Slc9a3r1 and Rlbp1 1 0.03 0 0 5.00
36 INT295870 Gene_expression of Srpk1 Negative_regulation of VEGFA 1 0.11 0 0 5.00
37 INT337914 sb Negative_regulation of Phosphorylation of Smad2 1 0.00 0.13 0 5.00
38 INT295856 Binding of Prkca and Srsf1 1 0.10 0 0 5.00
39 INT256980 Binding of Slc9a3r1 and Rpe 1 0.08 0.13 0 5.00
40 INT295855 Prkca Positive_regulation of Akt1 1 0.02 0 0 5.00
41 INT256993 Binding of Cd9 and Cd81 1 0.18 0.22 0 5.00
42 INT256983 Binding of Cd9 and Ezr 1 0.06 0.12 0 5.00
43 INT256992 Binding of Slc9a3r1 and Hspb6 1 0.09 0 0 5.00
44 INT256981 Binding of Dlg1 and Slc9a3r1 1 0.22 0 0 5.00
45 INT295871 Binding of RNPS1 and Srpk2 1 0.01 0.76 0 5.00
46 INT337918 sb Positive_regulation of Negative_regulation of Smad2 1 0.00 0.15 0 5.00
47 INT295859 Srsf1 Positive_regulation of Binding of U2af2 1 0.01 0 0 5.00
48 INT256989 Binding of Ezr and Slc9a3r1 1 0.10 0 0 5.00
49 INT337917 Binding of sb and Tgfbr1 1 0.00 1.06 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Proliferative Vitreoretinopathy. They are ordered first by their pain relevance and then by number of times they were reported in Proliferative Vitreoretinopathy. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT273613 Negative_regulation of PVR 7 0.17 5.06 1.26 100.00
2 INT213722 Positive_regulation of PVR 3 0.25 2.4 0.94 100.00
3 INT321960 Regulation of Negative_regulation of PVR 1 0.12 0.93 0.05 100.00
4 INT321963 Positive_regulation of Negative_regulation of PVR 1 0.12 0.93 0.05 100.00
5 INT123563 Negative_regulation of Rock1 7 0.55 16.56 5.78 99.52
6 INT37889 Gene_expression of P2ry2 75 0.65 26.01 23.8 98.40
7 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 98.24
8 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 98.24
9 INT55879 Gene_expression of CCL2 421 0.78 240.74 166.02 98.24
10 INT121241 Positive_regulation of P2rx7 65 0.69 40.94 13.59 97.40
11 INT69166 Positive_regulation of P2ry1 35 0.67 8.41 13.63 96.84
12 INT93122 Gene_expression of P2ry1 32 0.75 11.82 11.42 96.84
13 INT65509 Regulation of P2ry1 13 0.60 2.38 4.96 96.84
14 INT3330 Gene_expression of AGT 149 0.76 98.65 22.73 91.48
15 INT251327 Regulation of Binding of Bmpr2 1 0.20 2.27 0.27 90.76
16 INT251330 Regulation of Binding of Limk1 1 0.45 1.06 0.13 90.76
17 INT4535 Localization of PROC 106 0.73 76.24 21.1 90.60
18 INT251324 Binding of Bmpr2 5 0.23 2.99 0.34 90.48
19 INT251317 Binding of Limk1 1 0.37 1.69 0.23 90.48
20 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 90.04
21 INT10838 Positive_regulation of IL8 381 0.70 295.51 101.62 90.04
22 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 89.84
23 INT49519 Gene_expression of P2rx7 84 0.76 36.88 34.69 89.68
24 INT263403 Positive_regulation of Rock1 3 0.38 4.68 1.09 89.08
25 INT1767 Positive_regulation of PROC 83 0.67 54.14 17 88.24
26 INT10139 Positive_regulation of F13A1 64 0.56 44.75 9.69 85.04
27 INT9210 Regulation of IL6 166 0.62 125.61 49.95 84.48
28 INT10835 Regulation of IL8 79 0.49 53.04 24.14 84.24
29 INT66857 Regulation of CCL2 39 0.53 28.55 18.35 83.88
30 INT7610 Localization of Srf 3 0.67 0.98 0.27 83.60
31 INT4114 Gene_expression of Srf 9 0.70 6.11 2.63 83.16
32 INT18821 Positive_regulation of Gene_expression of Srf 2 0.35 0.63 0.31 83.16
33 INT215783 Localization of Gnas 1 0.12 1.64 0.76 81.96
34 INT215788 Localization of P2rx6 3 0.42 1.84 0.59 81.96
35 INT613 Gene_expression of Alb 268 0.78 149.84 42.78 81.32
36 INT205690 Positive_regulation of Positive_regulation of P2rx7 14 0.68 6.26 1.3 74.96
37 INT94608 Regulation of P2rx7 19 0.23 8.06 6.19 72.64
38 INT67981 Positive_regulation of CCL2 165 0.70 136.84 61.85 69.08
39 INT251322 Positive_regulation of Limk1 1 0.50 2.05 0.55 67.20
40 INT321961 Gene_expression of Rock1 1 0.51 0.79 0 65.44
41 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 64.64
42 INT99690 Negative_regulation of Positive_regulation of VEGFA 30 0.58 14.56 4.79 64.08
43 INT11047 Positive_regulation of Positive_regulation of IL6 45 0.66 28.7 9.37 63.80
44 INT75832 Positive_regulation of Positive_regulation of IL8 30 0.70 20.77 6.05 63.80
45 INT67980 Positive_regulation of Positive_regulation of CCL2 7 0.49 5.89 1.85 63.80
46 INT148301 Gene_expression of P2ry12 23 0.75 14.24 13.63 63.48
47 INT157378 Gene_expression of PDR 14 0.53 11.46 0.64 62.28
48 INT88327 Gene_expression of P2rx7 109 0.77 48.86 22.41 61.60
49 INT144830 Positive_regulation of Gene_expression of P2rx7 22 0.68 9.78 3.92 61.60
50 INT144828 Binding of P2rx7 19 0.47 7.84 3.16 61.60
51 INT134968 Localization of Ecm1 20 0.32 27.27 4.31 59.96
52 INT197973 Localization of Col4a1 2 0.73 2.15 0.26 59.96
53 INT25466 Binding of Rab38 6 0.00 2.23 3.28 57.08
54 INT321964 Binding of Rock1 1 0.28 0.96 0 54.96
55 INT100379 Positive_regulation of HIF1A 69 0.69 57.31 10.4 52.24
56 INT5328 Positive_regulation of CD4 191 0.69 133.43 21.31 51.76
57 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 50.40
58 INT111545 Phosphorylation of VEGFA 50 0.76 22.19 5.88 48.32
59 INT111547 Negative_regulation of Phosphorylation of VEGFA 13 0.42 5.08 3.22 48.32
60 INT205691 Regulation of Gene_expression of P2rx7 5 0.44 3.25 1.42 47.72
61 INT90491 Binding of Igf1 25 0.44 9.75 1.36 44.52
62 INT262796 Positive_regulation of Pycard 12 0.22 6.5 0.14 35.56
63 INT251332 Negative_regulation of Limk1 1 0.59 16.43 4.66 35.16
64 INT295864 Phosphorylation of RNPS1 1 0.02 0.81 0.04 34.32
65 INT9647 Gene_expression of PROC 163 0.65 89.76 26.75 34.12
66 INT51017 Positive_regulation of Icam1 113 0.70 81.16 35.55 34.08
67 INT48404 Regulation of Gene_expression of Icam1 21 0.62 15.1 7.81 33.56
68 INT48406 Gene_expression of Icam1 277 0.78 238.28 81.71 33.00
69 INT256952 Localization of Dlg1 1 0.55 0 0 31.28
70 INT256970 Localization of Cd81 1 0.71 0.16 0 30.40
71 INT19153 Gene_expression of lec 7 0.59 2.89 0.69 27.56
72 INT48202 Gene_expression of Tgfb1 146 0.78 89.93 27.76 27.44
73 INT134967 Gene_expression of Ecm1 66 0.29 38.4 7.16 27.40
74 INT321966 Positive_regulation of EZR 1 0.45 1 0 27.32
75 INT11258 Gene_expression of Gnas 58 0.58 21.6 6.33 26.72
76 INT251228 Phosphorylation of Tgfb1 4 0.15 1.18 0.24 26.08
77 INT13556 Gene_expression of CD4 367 0.78 230.82 41.74 25.56
78 INT104026 Negative_regulation of Fn1 10 0.22 9.22 1.43 22.84
79 INT130971 Binding of Slc9a3r1 2 0.39 0.32 0.59 18.48
80 INT69437 Positive_regulation of ROS1 328 0.58 222.83 40.56 17.92
81 INT83199 Gene_expression of Nos3 193 0.78 100.72 51.57 12.88
82 INT83200 Positive_regulation of Gene_expression of Nos3 48 0.70 24.75 12.99 12.88
83 INT256955 Binding of Cd81 1 0.46 1.19 0.11 12.24
84 INT62960 Gene_expression of P2rx2 149 0.77 58.31 59.16 11.76
85 INT22548 Positive_regulation of Casp3 483 0.70 258.78 213.07 5.00
86 INT48955 Gene_expression of Nos2 753 0.78 403.87 208.08 5.00
87 INT24326 Gene_expression of Ngf 346 0.78 218.67 184.71 5.00
88 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 5.00
89 INT64161 Positive_regulation of Prkca 213 0.70 85.06 129.91 5.00
90 INT5842 Gene_expression of Gfap 372 0.78 153.71 127.71 5.00
91 INT7533 Gene_expression of Tlr4 720 0.78 343.22 121.57 5.00
92 INT14151 Gene_expression of Casp3 311 0.78 140.26 120.68 5.00
93 INT5010 Gene_expression of Calca 197 0.78 85.76 118.75 5.00
94 INT12339 Localization of IL8 437 0.81 251.87 117.39 5.00
95 INT170025 Gene_expression of Fig4 588 0.67 183.27 113.32 5.00
96 INT12082 Localization of IL6 365 0.81 241.78 105.78 5.00
97 INT3537 Positive_regulation of Car2 413 0.56 103.51 94.35 5.00
98 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 5.00
99 INT48767 Negative_regulation of NOS1 312 0.59 154.25 90.32 5.00
100 INT64158 Negative_regulation of Prkca 121 0.59 29.8 88.66 5.00
101 INT48408 Gene_expression of ICAM1 494 0.78 340.08 88.6 5.00
102 INT64636 Positive_regulation of Gene_expression of Nos2 242 0.70 147.52 79.53 5.00
103 INT171145 Positive_regulation of Fig4 274 0.59 93.55 69.81 5.00
104 INT11318 Gene_expression of Gtf3a 274 0.52 183.82 60.89 5.00
105 INT64159 Gene_expression of Prkca 90 0.78 34.65 55.97 5.00
106 INT22546 Positive_regulation of Gene_expression of Casp3 97 0.70 47.89 51.92 5.00
107 INT52264 Gene_expression of IK 180 0.77 90.87 51.87 5.00
108 INT17915 Gene_expression of Insr 141 0.75 47.45 48.59 5.00
109 INT106525 Phosphorylation of Akt1 436 0.82 183.81 47.82 5.00
110 INT30170 Gene_expression of Car2 330 0.66 77.26 46.76 5.00
111 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53 5.00
112 INT17561 Localization of Car2 303 0.79 60.95 44.52 5.00
113 INT173693 Localization of Gopc 249 0.65 70.49 38.81 5.00
114 INT20210 Localization of Ngf 69 0.79 46.22 38.57 5.00
115 INT101992 Localization of VEGFA 413 0.81 258.23 36.15 5.00
116 INT60710 Gene_expression of Col7a1 217 0.78 113.2 35.2 5.00
117 INT14559 Gene_expression of Igf1 254 0.78 112 34.17 5.00
118 INT81289 Positive_regulation of Gene_expression of Tlr4 192 0.69 104.5 33.89 5.00
119 INT65698 Localization of CCL2 118 0.81 77.54 32.69 5.00
120 INT48693 Regulation of VEGFA 268 0.62 191.88 31.52 5.00
121 INT99688 Negative_regulation of Gene_expression of VEGFA 274 0.58 201.8 31.1 5.00
122 INT3777 Positive_regulation of NARFL 256 0.56 302.43 25.74 5.00
123 INT86789 Gene_expression of P2rx4 46 0.77 30.66 25.68 5.00
124 INT14556 Positive_regulation of Igf1 105 0.69 52.21 24.04 5.00
125 INT78057 Localization of Tlr4 140 0.77 67.75 21.72 5.00
126 INT7535 Negative_regulation of Tlr4 111 0.56 56.84 21.37 5.00
127 INT48692 Binding of VEGFA 345 0.48 210.3 21.31 5.00
128 INT112427 Positive_regulation of P2rx4 27 0.68 26.29 21.31 5.00
129 INT78901 Localization of CCL5 67 0.78 40.79 20.59 5.00
130 INT56749 Gene_expression of PCNA 219 0.77 111.25 18.42 5.00
131 INT68681 Transcription of VEGFA 132 0.71 80.47 17.03 5.00
132 INT35998 Positive_regulation of Gene_expression of Calca 31 0.70 16.16 16.98 5.00
133 INT48238 Regulation of Gene_expression of Ngf 25 0.62 11.48 16.42 5.00
134 INT48540 Gene_expression of Kcna5 37 0.77 14.04 16.07 5.00
135 INT109535 Gene_expression of Vegfa 116 0.75 84.61 14.89 5.00
136 INT65263 Positive_regulation of Gene_expression of Igf1 61 0.69 25.69 14.49 5.00
137 INT1982 Regulation of NARFL 119 0.49 116.2 14.35 5.00
138 INT108063 Gene_expression of Adora2a 29 0.78 13.11 13.78 5.00
139 INT69878 Positive_regulation of Gene_expression of Gtf3a 48 0.29 36.78 13.57 5.00
140 INT76469 Positive_regulation of Gene_expression of Prkca 18 0.46 7.9 13.36 5.00
141 INT26545 Gene_expression of Hras1 173 0.78 79.54 13.21 5.00
142 INT12135 Gene_expression of PLEK 62 0.75 34.13 12.47 5.00
143 INT92686 Gene_expression of Ctgf 51 0.77 34.4 11.93 5.00
144 INT72784 Positive_regulation of Adora2a 26 0.70 16.52 11.47 5.00
145 INT48203 Positive_regulation of Tgfb1 67 0.70 41.31 11.07 5.00
146 INT101203 Negative_regulation of Gene_expression of Calca 12 0.59 7.06 10.72 5.00
147 INT69035 Positive_regulation of Casp1 43 0.69 25.18 10.67 5.00
148 INT102865 Positive_regulation of Positive_regulation of Prkca 25 0.69 8.34 9.9 5.00
149 INT73427 Localization of P2rx7 24 0.79 8.65 9.87 5.00
150 INT2036 Localization of EGF 42 0.77 21.5 9.74 5.00
151 INT178306 Negative_regulation of Gene_expression of Gopc 71 0.37 26.43 9.74 5.00
152 INT95271 Negative_regulation of Nos3 46 0.53 24.1 9.71 5.00
153 INT75137 Regulation of Akt1 74 0.48 37.89 9.7 5.00
154 INT112428 Positive_regulation of Gene_expression of P2rx4 12 0.68 12.67 9.57 5.00
155 INT62919 Regulation of Gnas 22 0.43 5.61 9.55 5.00
156 INT48257 Negative_regulation of P2rx7 18 0.41 7.82 8.42 5.00
157 INT113987 Localization of IK 29 0.23 16.73 8.25 5.00
158 INT94082 Regulation of Gene_expression of IK 19 0.23 10.03 7.93 5.00
159 INT98178 Localization of Casp3 32 0.65 21.01 7.77 5.00
160 INT47994 Negative_regulation of Lipg 45 0.50 27.19 7.24 5.00
161 INT91351 Gene_expression of P2rx1 28 0.75 5.89 6.78 5.00
162 INT16389 Gene_expression of Plg 80 0.67 36.88 6.74 5.00
163 INT14560 Regulation of Igf1 41 0.59 19.59 6.3 5.00
164 INT39758 Gene_expression of Fn1 57 0.65 34.38 6.02 5.00
165 INT48911 Binding of NOS1 24 0.40 11.21 5.89 5.00
166 INT86111 Positive_regulation of Positive_regulation of VEGFA 38 0.69 33.81 5.78 5.00
167 INT151032 Localization of Igf1 49 0.76 26.32 5.71 5.00
168 INT56803 Positive_regulation of Bcl2a1a 12 0.47 7.29 5.65 5.00
169 INT95170 Localization of P2ry1 10 0.78 5.08 5.63 5.00
170 INT137886 Gene_expression of Bcl2a1a 17 0.55 8.58 5.44 5.00
171 INT27952 Transcription of Ngf 12 0.72 5.34 5.43 5.00
172 INT145680 Regulation of P2rx7 22 0.61 11.92 5.42 5.00
173 INT92682 Positive_regulation of Gene_expression of Ctgf 17 0.69 12.16 4.51 5.00
174 INT98357 Binding of Gnas 11 0.41 1.87 4.35 5.00
175 INT185484 Positive_regulation of Gene_expression of P2rx7 8 0.31 7.44 4.28 5.00
176 INT10923 Positive_regulation of Lipg 30 0.50 22.87 4.26 5.00
177 INT144396 Positive_regulation of P2rx1 11 0.49 3.25 4.23 5.00
178 INT69681 Negative_regulation of Tgfb1 42 0.51 22.28 4 5.00
179 INT86369 Positive_regulation of Gene_expression of PCNA 40 0.67 26.66 3.57 5.00
180 INT122051 Negative_regulation of ROM1 17 0.48 9.11 3.38 5.00
181 INT22375 Localization of PDGFA 21 0.75 15.46 3.25 5.00
182 INT115790 Negative_regulation of P2rx6 8 0.47 4.13 3.19 5.00
183 INT75484 Gene_expression of Tgfbr1 21 0.64 13.36 3.15 5.00
184 INT146693 Gene_expression of Mbl1 17 0.59 10.99 3.13 5.00
185 INT66367 Gene_expression of Gsk3b 16 0.45 9.75 3.07 5.00
186 INT110445 Phosphorylation of Gtf3a 15 0.09 5.58 3.07 5.00
187 INT112429 Negative_regulation of Positive_regulation of P2rx4 4 0.57 4.03 2.94 5.00
188 INT155453 Protein_catabolism of Mapk14 6 0.36 4.24 2.85 5.00
189 INT65629 Positive_regulation of Gene_expression of Kcna5 5 0.69 2.48 2.76 5.00
190 INT48198 Binding of Tgfb1 29 0.47 19.59 2.46 5.00
191 INT115401 Negative_regulation of P2ry1 6 0.42 1.27 2.25 5.00
192 INT126513 Gene_expression of Col1a1 23 0.75 10.92 2.18 5.00
193 INT94835 Localization of NUDT6 13 0.52 11.57 2 5.00
194 INT105162 Gene_expression of Ad 47 0.12 46.53 1.83 5.00
195 INT134965 Negative_regulation of Ecm1 7 0.18 7.86 1.7 5.00
196 INT33393 Positive_regulation of Gene_expression of PLEK 9 0.67 7.35 1.65 5.00
197 INT160264 Localization of Fn1 10 0.40 3.95 1.51 5.00
198 INT142719 Binding of Col1a1 7 0.34 5.83 1.47 5.00
199 INT255251 Negative_regulation of Smad2 12 0.32 5.69 1.44 5.00
200 INT60600 Binding of PSS 5 0.32 3.59 1.42 5.00
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