D:Prostate Or Kidney Disorder

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Disease Term
Synonyms DISEASE OF PROSTATE, Diseases Of Prostate, DISORDER OF KIDNEY, Disorder Of Prostate, Disorders Of Prostate, Kidney Disease, Kidney Diseases, Kidney Disorder, KIDNEY DISORDERS, Nephrologic Disease, Nephrologic Diseases
Documents 68
Hot Single Events 21
Hot Interactions 8

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Prostate Or Kidney Disorder. They are ordered first by their relevance to Prostate Or Kidney Disorder and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT324305 Binding of CST3 and UMOD 1 0.05 3.22 0 90.32
2 INT324313 Binding of STC1 and UMOD 1 0.29 3.22 0 90.32
3 INT324312 Binding of GATM and UMOD 1 0.02 1.62 0 90.32
4 INT324306 Binding of GATM and STC1 1 0.02 1.61 0 90.32
5 INT324311 Binding of UMOD and SHROOM3 1 0.29 1.62 0 90.32
6 INT324310 Binding of STC1 and SHROOM3 1 0.24 1.61 0 90.32
7 INT324309 Binding of CST3 and GATM 1 0.00 1.6 0 90.32
8 INT324308 Binding of CST3 and SHROOM3 1 0.04 1.6 0 90.32
9 INT192971 Positive_regulation of Il6 Positive_regulation of Localization of Stat3 1 0.03 0.86 0.56 66.28
10 INT324347 Binding of UMOD and Scr 1 0.20 2.23 0 62.88
11 INT324340 Binding of SLC12A1 and Scr 1 0.00 1.42 0 55.36
12 INT270330 Binding of HYAL1 and TIMP1 1 0.00 0.2 0.04 50.00
13 INT178437 Mapk8 Positive_regulation of Jun 3 0.40 2.69 0.58 5.00
14 INT27730 Binding of ALB and Shbg 2 0.01 0.44 0.5 5.00
15 INT178446 Binding of Egfr and ras 1 0.04 0.13 0.13 5.00
16 INT178431 Positive_regulation of Binding of Egfr and ras 1 0.05 0.13 0.13 5.00
17 INT178434 Il6 Positive_regulation of Ar 1 0.01 0.93 0.08 5.00
18 INT329429 Binding of Col7a1 and Hmgcr 1 0.01 0.28 0.06 5.00
19 INT178438 Mapk8 Positive_regulation of Plau 1 0.06 0.52 0.06 5.00
20 INT178430 Pawr Positive_regulation of Phosphorylation of Mapk14 1 0.05 0.29 0.05 5.00
21 INT178447 Negative_regulation of Pawr Positive_regulation of Phosphorylation of Mapk14 1 0.05 0.29 0.05 5.00
22 INT178443 Negative_regulation of Mapk8 Positive_regulation of Negative_regulation of Mapk14 1 0.13 0.76 0.04 5.00
23 INT178441 Binding of Ar and Sra1 1 0.00 0.45 0.04 5.00
24 INT178435 Mapk1 Regulation of Phosphorylation of Src 1 0.03 0.49 0.04 5.00
25 INT178436 Mapk14 Positive_regulation of Gene_expression of Hist1h1a 1 0.17 0.2 0.04 5.00
26 INT178439 Binding of Ar and Src 1 0.01 0.44 0.04 5.00
27 INT178428 Regulation of Il6 Positive_regulation of Ar 1 0.01 0.47 0.04 5.00
28 INT178442 Mapk1 Regulation of Gene_expression of Il6 1 0.03 0.59 0.03 5.00
29 INT324342 UMOD Positive_regulation of Scr 1 0.17 1.29 0 5.00
30 INT178440 Map2k4 Positive_regulation of Mapk14 1 0.04 0.13 0 5.00
31 INT178448 Mapk1 Regulation of Localization of VEGFA 1 0.01 0.51 0 5.00
32 INT324346 Regulation of UMOD Positive_regulation of Scr 1 0.10 1.31 0 5.00
33 INT324343 SLC12A1 Regulation of Scr 1 0.00 0.25 0 5.00
34 INT178433 Fgf1 Positive_regulation of Mapk14 1 0.02 0.65 0 5.00
35 INT178445 Map2k4 Positive_regulation of Mapk8 1 0.11 0.13 0 5.00
36 INT324344 Positive_regulation of UMOD Regulation of Scr 1 0.24 0.29 0 5.00
37 INT178432 Map2k7 Positive_regulation of Mapk8 1 0.11 0.13 0 5.00
38 INT324345 Binding of STC1 and Scr 1 0.10 0.22 0 5.00
39 INT178429 Negative_regulation of Mapk1 Negative_regulation of Positive_regulation of Eno2 1 0.02 0.73 0 5.00
40 INT324341 UMOD Regulation of Scr 1 0.21 0.29 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Prostate Or Kidney Disorder. They are ordered first by their pain relevance and then by number of times they were reported in Prostate Or Kidney Disorder. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT102825 Regulation of Timp1 10 0.38 5.49 1.79 99.04
2 INT243185 Regulation of CXCL5 4 0.34 2.16 0.99 99.04
3 INT111613 Regulation of PTGDS 6 0.52 3.29 0.93 99.04
4 INT37869 Regulation of ACPP 3 0.34 3.03 0.31 99.04
5 INT207728 Regulation of KLK11 2 0.39 2.68 0.14 99.04
6 INT290119 Regulation of FGFBP1 1 0.36 0.63 0.03 99.04
7 INT290111 Regulation of Fkbp11 1 0.38 0.63 0.03 99.04
8 INT62957 Positive_regulation of CXCL5 13 0.50 8.53 3.28 96.24
9 INT80857 Negative_regulation of Cpt2 19 0.42 12.1 1.6 95.92
10 INT324332 Binding of UMOD 7 0.41 7.07 0.35 94.84
11 INT95787 Positive_regulation of Mapk1 568 0.70 226.51 220.94 88.76
12 INT11159 Gene_expression of EGFR 698 0.78 548.93 25.69 87.52
13 INT11154 Binding of EGFR 149 0.48 96.23 6.29 87.52
14 INT14501 Gene_expression of CST3 28 0.75 25.77 5.16 87.32
15 INT192970 Negative_regulation of Hp 7 0.22 6.99 4.06 86.60
16 INT170054 Negative_regulation of Gopc 280 0.38 117.89 42.4 86.08
17 INT49441 Negative_regulation of Cpox 494 0.59 303.22 177.46 85.52
18 INT260295 Gene_expression of FGFBP1 2 0.62 2.78 0.06 85.40
19 INT290115 Localization of FGFBP1 1 0.64 0.81 0.03 85.40
20 INT71807 Negative_regulation of Cp 18 0.58 8.9 1.88 84.96
21 INT324331 Binding of SHROOM3 1 0.29 1.41 0 83.40
22 INT192969 Negative_regulation of Gene_expression of Hp 1 0.32 1.06 0.59 78.52
23 INT192967 Gene_expression of Hp 14 0.43 8.06 11.01 78.08
24 INT181395 Gene_expression of Ccl8 11 0.67 13.88 4.56 78.08
25 INT233551 Gene_expression of Apod 8 0.74 12.25 1.4 78.08
26 INT290113 Gene_expression of Fkbp11 1 0.65 0.95 0 76.76
27 INT9158 Gene_expression of Tnf 722 0.78 522.01 277.68 75.36
28 INT28359 Gene_expression of Pdcd1 39 0.57 34.09 3.4 72.88
29 INT339606 Regulation of Gene_expression of Pdcd1 2 0.05 1.13 0.32 72.88
30 INT67039 Positive_regulation of Cpox 144 0.65 98.4 33.77 72.56
31 INT121036 Positive_regulation of Transcription of Cpox 12 0.21 6.34 2.04 72.56
32 INT75768 Transcription of Cpox 37 0.27 19.41 9.79 72.24
33 INT15775 Positive_regulation of Ren1 50 0.69 22.38 6.19 69.76
34 INT40053 Positive_regulation of Positive_regulation of Ren1 4 0.54 4.41 0.81 69.76
35 INT9657 Positive_regulation of Gene_expression of Il6 237 0.70 180.45 63.6 67.92
36 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 67.32
37 INT8243 Positive_regulation of Il6 451 0.70 358.24 119.28 66.28
38 INT11936 Positive_regulation of Positive_regulation of Il6 34 0.50 26.85 10.59 66.28
39 INT295510 Negative_regulation of Sptlc1 4 0.11 2.11 0 65.96
40 INT158630 Positive_regulation of Positive_regulation of Stat3 16 0.49 14.75 3.08 65.08
41 INT192965 Localization of Stat3 15 0.74 7.05 1.68 64.60
42 INT39448 Gene_expression of Scr 13 0.67 5.18 2.96 64.44
43 INT129584 Positive_regulation of Stat3 97 0.68 87.07 14.86 63.92
44 INT192963 Transcription of Hp 2 0.39 1.32 0.67 62.12
45 INT192966 Positive_regulation of Transcription of Hp 1 0.38 0.82 0.55 62.12
46 INT181352 Positive_regulation of Ccl8 3 0.53 5.44 1.23 62.08
47 INT20230 Negative_regulation of Positive_regulation of Alb 15 0.56 12.44 4.11 62.00
48 INT247955 Binding of Pdcd1 5 0.12 4.85 0.4 61.36
49 INT96068 Positive_regulation of Timp1 30 0.58 23.94 8.17 61.32
50 INT192968 Positive_regulation of Gene_expression of Hp 2 0.28 1.34 1.44 60.48
51 INT49439 Gene_expression of Cpox 508 0.73 326.97 130.17 59.60
52 INT83611 Negative_regulation of Gene_expression of Cpox 55 0.29 31.09 11.5 59.60
53 INT3971 Positive_regulation of Alb 175 0.70 98.46 36.45 58.60
54 INT192964 Positive_regulation of Hp 7 0.28 2 2.75 58.32
55 INT339608 Localization of Ido1 1 0.14 0.41 0.08 57.84
56 INT90792 Localization of Il10 144 0.80 87.88 30.03 57.20
57 INT60970 Positive_regulation of Scr 9 0.59 12.21 1.03 55.56
58 INT11949 Negative_regulation of Apob 11 0.09 8.13 0.85 55.28
59 INT23638 Negative_regulation of GAL 17 0.42 5.68 5.04 53.44
60 INT62507 Regulation of Scr 3 0.16 2.45 0.4 52.32
61 INT233330 Localization of LEFTY2 4 0.15 4.46 0.99 51.92
62 INT192287 Gene_expression of Cpd 7 0.49 4.6 0 51.00
63 INT3550 Negative_regulation of GLA 52 0.59 33.93 5.26 50.72
64 INT270331 Negative_regulation of CLNK 1 0.05 0.7 0.03 50.40
65 INT85653 Regulation of Gene_expression of Cpox 24 0.24 20.55 5.22 50.12
66 INT175652 Positive_regulation of BPHL 9 0.44 17.98 1.14 50.00
67 INT68446 Negative_regulation of Cpt1a 5 0.38 6.5 0.56 49.44
68 INT78990 Regulation of Cpox 72 0.57 35.22 18.16 47.92
69 INT308161 Negative_regulation of CPT1B 1 0.08 0.46 0 47.40
70 INT50083 Binding of SLC12A1 2 0.01 1.01 0.15 47.32
71 INT92837 Negative_regulation of Gene_expression of Nos2 116 0.59 59.67 31.82 40.36
72 INT77434 Positive_regulation of Gene_expression of Nos2 151 0.69 96.76 38.94 39.84
73 INT69993 Positive_regulation of Gene_expression of Cpox 93 0.55 69.4 22.05 39.84
74 INT66280 Gene_expression of Nos2 534 0.78 330.78 157.07 38.64
75 INT91754 Gene_expression of Cp 42 0.77 21.97 5.38 37.20
76 INT96150 Gene_expression of H2-D1 44 0.27 16.23 3.4 32.56
77 INT187458 Positive_regulation of Gene_expression of H2-D1 11 0.14 4.85 1.44 32.56
78 INT126376 Gene_expression of Gli1 8 0.68 4.52 0.7 30.24
79 INT290112 Positive_regulation of Gene_expression of Gli1 1 0.50 1.09 0.05 30.24
80 INT290114 Negative_regulation of Gene_expression of Gli1 1 0.31 1.09 0.05 30.24
81 INT58917 Negative_regulation of Zdhhc7 2 0.51 1.06 0.08 28.64
82 INT134798 Gene_expression of ANXA1 15 0.75 13.94 2.99 26.04
83 INT290117 Negative_regulation of Gene_expression of ANXA1 1 0.57 1.15 0.08 26.04
84 INT17685 Negative_regulation of Cog1 23 0.42 15.65 3.56 25.00
85 INT36142 Negative_regulation of Hmgcr 33 0.46 15.91 3.54 25.00
86 INT36064 Binding of CST3 14 0.47 16.38 1.12 16.08
87 INT85078 Positive_regulation of PCNA 36 0.49 17.06 2.81 12.56
88 INT11266 Positive_regulation of UMOD 2 0.43 1.25 1.16 12.48
89 INT81640 Positive_regulation of Gene_expression of Bcl2 106 0.69 84.58 11.63 9.80
90 INT168262 Positive_regulation of Gene_expression of BPHL 10 0.24 10.72 0.83 9.80
91 INT329426 Positive_regulation of Actg2 1 0.08 0.2 0.04 9.60
92 INT77307 Gene_expression of Bcl2 399 0.77 319.77 38 9.44
93 INT24149 Gene_expression of BPHL 58 0.59 93.54 2.91 9.24
94 INT324333 Transcription of CST3 1 0.67 0.2 0 9.20
95 INT5127 Localization of Lhb 488 0.80 50.48 162.66 5.00
96 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 5.00
97 INT64161 Positive_regulation of Prkca 213 0.70 85.06 129.91 5.00
98 INT7395 Localization of GNRH1 399 0.81 62.88 117.68 5.00
99 INT27096 Positive_regulation of Nfkb1 325 0.70 195.11 109.06 5.00
100 INT940 Negative_regulation of Ptgs1 219 0.59 104.34 95.97 5.00
101 INT96917 Positive_regulation of Mapk14 261 0.70 173.29 88.79 5.00
102 INT92434 Phosphorylation of Mapk1 287 0.82 91.65 83.46 5.00
103 INT25363 Negative_regulation of Trpv1 144 0.59 64.78 75.7 5.00
104 INT98621 Regulation of Trpv1 121 0.62 79.24 75.23 5.00
105 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07 5.00
106 INT14740 Gene_expression of TGFB1 272 0.78 168.48 60.18 5.00
107 INT546 Binding of ALB 311 0.48 85.98 60.14 5.00
108 INT5710 Negative_regulation of Localization of Lhb 146 0.57 20.51 58.33 5.00
109 INT64159 Gene_expression of Prkca 90 0.78 34.65 55.97 5.00
110 INT96914 Phosphorylation of Mapk14 168 0.82 108.46 53.32 5.00
111 INT110023 Negative_regulation of Mapk14 127 0.59 84.27 45.42 5.00
112 INT16364 Gene_expression of HLA-DRA 234 0.78 118.81 45.01 5.00
113 INT613 Gene_expression of Alb 268 0.78 149.84 42.78 5.00
114 INT65245 Gene_expression of Nos3 121 0.78 98.14 41.56 5.00
115 INT114751 Gene_expression of Mapk1 137 0.76 60.14 39.98 5.00
116 INT102611 Negative_regulation of Positive_regulation of Mapk1 74 0.58 35.57 39.37 5.00
117 INT101992 Localization of VEGFA 413 0.81 258.23 36.15 5.00
118 INT60710 Gene_expression of Col7a1 217 0.78 113.2 35.2 5.00
119 INT7675 Gene_expression of ENG 146 0.77 45.35 34.6 5.00
120 INT96913 Positive_regulation of Mapk8 179 0.69 130.44 32.2 5.00
121 INT117112 Negative_regulation of Mapk1 87 0.56 40.34 31.18 5.00
122 INT110020 Gene_expression of Mapk14 142 0.77 72.33 30.08 5.00
123 INT7397 Negative_regulation of Localization of GNRH1 86 0.59 15.45 29.78 5.00
124 INT6660 Positive_regulation of Jun 148 0.69 67.58 29.73 5.00
125 INT28361 Gene_expression of TP53 443 0.78 384.86 28.8 5.00
126 INT16428 Positive_regulation of Gtf3a 135 0.20 106.44 26.67 5.00
127 INT95788 Positive_regulation of Positive_regulation of Mapk1 83 0.69 24.75 25.84 5.00
128 INT43486 Positive_regulation of Ifng 52 0.69 32.71 24.77 5.00
129 INT14556 Positive_regulation of Igf1 105 0.69 52.21 24.04 5.00
130 INT47741 Negative_regulation of Flvcr2 43 0.51 5.72 23.37 5.00
131 INT1561 Negative_regulation of Dnahc8 59 0.59 18.12 20.99 5.00
132 INT65260 Positive_regulation of Col7a1 95 0.69 61.73 18.42 5.00
133 INT9656 Regulation of Gene_expression of Il6 57 0.62 33.3 17.71 5.00
134 INT111531 Negative_regulation of Phosphorylation of Mapk14 37 0.50 20 17.68 5.00
135 INT109316 Negative_regulation of Mapk8 72 0.59 50.59 17.24 5.00
136 INT12922 Gene_expression of Atp9a 115 0.75 50.95 17.01 5.00
137 INT170051 Positive_regulation of Gene_expression of Gopc 150 0.43 56.75 16.93 5.00
138 INT95790 Regulation of Mapk1 55 0.61 21.17 16.31 5.00
139 INT56447 Positive_regulation of Icam1 64 0.64 64.14 16.16 5.00
140 INT170308 Gene_expression of Ido1 159 0.75 69.51 15.98 5.00
141 INT2630 Positive_regulation of Shbg 134 0.70 65.26 15.19 5.00
142 INT96911 Positive_regulation of Phosphorylation of Mapk14 46 0.70 43.03 15.15 5.00
143 INT24670 Gene_expression of FGF2 121 0.78 85.64 15.12 5.00
144 INT108480 Gene_expression of CCL21 53 0.77 37.87 14.42 5.00
145 INT16321 Gene_expression of Cd3e 111 0.72 49.9 14.21 5.00
146 INT73641 Regulation of Lep 45 0.62 26.2 12.59 5.00
147 INT24876 Gene_expression of CD34 172 0.78 91.02 12.39 5.00
148 INT7234 Binding of GNRH1 43 0.47 21.59 12.36 5.00
149 INT119396 Regulation of Positive_regulation of Mapk1 22 0.61 7.88 12.25 5.00
150 INT117113 Regulation of Mapk14 28 0.45 16.71 11.99 5.00
151 INT109315 Gene_expression of Mapk8 70 0.78 45.46 11.65 5.00
152 INT69029 Gene_expression of PTPRC 127 0.75 74.26 11.57 5.00
153 INT96915 Phosphorylation of Mapk8 73 0.81 40.69 11.44 5.00
154 INT168409 Positive_regulation of Ccl5 47 0.64 45.84 10.83 5.00
155 INT87451 Positive_regulation of Mapk3 34 0.67 12.82 10.38 5.00
156 INT145695 Regulation of Mapk8 26 0.62 14.67 9.83 5.00
157 INT24328 Gene_expression of Egf 97 0.75 59.65 9.42 5.00
158 INT13010 Gene_expression of TYR 38 0.65 14.81 8.84 5.00
159 INT34777 Localization of IGF1 82 0.80 42.68 8.62 5.00
160 INT15723 Gene_expression of Fn1 47 0.78 37.59 8.51 5.00
161 INT96912 Positive_regulation of Phosphorylation of Mapk8 29 0.69 18.33 8.14 5.00
162 INT126478 Gene_expression of Cxcl12 78 0.77 58.69 8.01 5.00
163 INT113705 Gene_expression of Egfr 228 0.78 149.05 7.59 5.00
164 INT182750 Gene_expression of Hmgcr 61 0.58 17.23 7.4 5.00
165 INT93664 Gene_expression of TIMP2 33 0.67 36.67 7.14 5.00
166 INT86805 Localization of HGF 49 0.71 28.48 6.35 5.00
167 INT61258 Transcription of Nfkb1 24 0.67 10.89 6.32 5.00
168 INT60713 Binding of Col7a1 47 0.43 22.52 6.29 5.00
169 INT57256 Gene_expression of HLA-DQA2 52 0.55 23.87 6.27 5.00
170 INT65265 Positive_regulation of Gene_expression of Col7a1 48 0.69 23.81 6.16 5.00
171 INT61417 Gene_expression of ITGAL 36 0.75 29.62 6.15 5.00
172 INT26585 Gene_expression of Vim 117 0.77 39.97 6 5.00
173 INT126481 Gene_expression of Cxcr4 69 0.77 34.99 6 5.00
174 INT27591 Negative_regulation of Gene_expression of Alb 30 0.58 17.03 5.99 5.00
175 INT112124 Positive_regulation of Egfr 71 0.70 47.82 5.61 5.00
176 INT134966 Localization of Col7a1 23 0.42 16.4 5.24 5.00
177 INT111100 Gene_expression of Dusp1 18 0.76 14.81 5.21 5.00
178 INT135291 Positive_regulation of Positive_regulation of Mapk8 24 0.64 19.37 5.16 5.00
179 INT131717 Positive_regulation of Gene_expression of Mapk8 18 0.55 14.25 5.02 5.00
180 INT106524 Phosphorylation of Jun 23 0.80 15.35 4.78 5.00
181 INT101594 Positive_regulation of Cd40 36 0.69 16.14 4.56 5.00
182 INT4679 Negative_regulation of RAPGEF5 55 0.57 47.51 4.55 5.00
183 INT11565 Gene_expression of Tf 24 0.68 5.89 4.36 5.00
184 INT48411 Gene_expression of Cd44 35 0.77 27.05 4.29 5.00
185 INT75523 Regulation of MAPK8 21 0.33 11.18 4.28 5.00
186 INT158416 Localization of Mapk1 19 0.67 5.32 4.18 5.00
187 INT38066 Binding of MSC 14 0.41 5.28 4.12 5.00
188 INT23653 Binding of Egf 22 0.36 11.34 4.12 5.00
189 INT170738 Binding of Icam1 23 0.37 25.49 4.09 5.00
190 INT156137 Gene_expression of Col1a2 28 0.73 13.3 3.99 5.00
191 INT126477 Gene_expression of Sdf2l1 43 0.66 22.02 3.97 5.00
192 INT149259 Gene_expression of RCT 38 0.67 15.73 3.87 5.00
193 INT62784 Gene_expression of NT5E 46 0.65 15.95 3.72 5.00
194 INT31758 Positive_regulation of Egf 32 0.66 19.42 3.64 5.00
195 INT157805 Negative_regulation of Gene_expression of Col7a1 22 0.34 12.85 3.51 5.00
196 INT102442 Gene_expression of S1pr4 6 0.29 2.17 3.51 5.00
197 INT28528 Gene_expression of MSMB 25 0.65 7.66 3.49 5.00
198 INT19491 Gene_expression of CD19 44 0.75 28.8 3.47 5.00
199 INT137350 Phosphorylation of Src 13 0.45 4.14 3.32 5.00
200 INT19211 Binding of Shbg 35 0.48 16.29 3.31 5.00
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