D:Prostatic Intraepithelial Neoplasia

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Disease Term
Synonyms Intraepithelial Neoplasia Prostatic, Intraepithelial Neoplasm Prostatic, INTRAEPITHELIAL NEOPLASMS PROSTATIC, Intraepithelial Prostatic Neoplasia, INTRAEPITHELIAL PROSTATIC NEOPLASIAS, Neoplasia Intraepithelial Prostatic, Neoplasia Prostatic Intraepithelial, Neoplasm Prostatic Intraepithelial, NEOPLASMS PROSTATIC INTRAEPITHELIAL, Prostatic Intraepithelial Neoplasias, Prostatic Intraepithelial Neoplasm
Documents 23
Hot Single Events 24
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Prostatic Intraepithelial Neoplasia. They are ordered first by their relevance to Prostatic Intraepithelial Neoplasia and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT279420 CPOX Positive_regulation of VEGFC 1 0.04 2.23 0.07 76.68
2 INT279415 Gene_expression of CPOX Positive_regulation of VEGFC 1 0.04 2.23 0.07 76.68
3 INT279414 Binding of CPOX and ACTR1B 1 0.04 1.55 0.4 60.00
4 INT173058 INCENP Positive_regulation of Gene_expression of VEGFA 1 0.03 1.48 0.08 22.96
5 INT173057 Positive_regulation of HIF1A Positive_regulation of Gene_expression of VEGFA 1 0.24 1.49 0.08 21.28
6 INT173060 Negative_regulation of VHLL Positive_regulation of Positive_regulation of HIF1A 1 0.04 0.66 0.04 8.56
7 INT173059 Binding of KDR and VEGFA 43 0.43 29.63 1.1 5.00
8 INT173120 Binding of PPARA and NR1H4 8 0.09 2.79 0.23 5.00
9 INT276228 Nrtim1 Positive_regulation of PPARG 1 0.01 2.18 0.14 5.00
10 INT173061 Binding of HIF1A and LILRA3 1 0.03 1.24 0.09 5.00
11 INT173062 Binding of HIF1A and VHLL 1 0.04 1.26 0.09 5.00
12 INT279435 Positive_regulation of Binding of LTA4H and Lts1 1 0.00 0.16 0.08 5.00
13 INT279419 RARB Regulation of PPARA 1 0.01 0.13 0.08 5.00
14 INT279416 NR1H4 Regulation of PPARA 1 0.01 0.13 0.08 5.00
15 INT279436 Binding of LTA4H and Lts1 1 0.00 0.16 0.08 5.00
16 INT173106 VEGFA Positive_regulation of Fos 1 0.44 0.64 0.08 5.00
17 INT279421 Binding of NR1H4 and MLXIPL 1 0.00 0.27 0.07 5.00
18 INT279413 Binding of RARB and MLXIPL 1 0.00 0.27 0.07 5.00
19 INT279417 Binding of PPARA and MLXIPL 3 0.00 0.33 0.07 5.00
20 INT173052 Binding of LILRA3 and VHLL 1 0.01 0.62 0.05 5.00
21 INT173053 Binding of VEGFA and NRP2 3 0.12 1.36 0.04 5.00
22 INT173056 Binding of NRP2 and NRP1 2 0.24 0.61 0.04 5.00
23 INT173051 Binding of VEGFA and NRP1 16 0.44 1.29 0.04 5.00
24 INT279418 Binding of PPARA and RARB 1 0.01 0.14 0.03 5.00
25 INT291714 Binding of RARA and Rxra 3 0.07 0.2 0.03 5.00
26 INT173055 Binding of VEGFA and NCOR2 1 0.02 0.34 0.03 5.00
27 INT182918 Binding of DR1 and RARA 2 0.08 0 0 5.00
28 INT291715 Binding of DR1 and Rxra 1 0.09 0 0 5.00
29 INT173054 NRP1 Positive_regulation of KDR 1 0.08 0.34 0 5.00
30 INT291716 Binding of SOD1 and Rxra 1 0.21 0 0 5.00
31 INT291682 Positive_regulation of Binding of RARA and TNFRSF10B 1 0.03 0 0 5.00
32 INT291712 Binding of Rxra and SPNS1 1 0.04 0 0 5.00
33 INT291683 Binding of RARA and TNFRSF10B 1 0.03 0 0 5.00
34 INT291711 Rxra Positive_regulation of VDR 1 0.09 0 0 5.00
35 INT291713 Binding of TNFRSF10B and Rxra 1 0.05 0 0 5.00
36 INT173050 Binding of VEGFA and NRP1 Positive_regulation of KDR 1 0.08 0.35 0 5.00
37 INT291681 Positive_regulation of Binding of DR1 and RARA 1 0.06 0 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Prostatic Intraepithelial Neoplasia. They are ordered first by their pain relevance and then by number of times they were reported in Prostatic Intraepithelial Neoplasia. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT263822 Positive_regulation of Gene_expression of LOX 8 0.50 11 1.06 100.00
2 INT27260 Gene_expression of DYNLL1 8 0.75 7.72 2.78 100.00
3 INT24149 Gene_expression of BPHL 58 0.59 93.54 2.91 100.00
4 INT50670 Gene_expression of CPOX 763 0.76 442.13 195.02 99.72
5 INT90673 Gene_expression of LOX 66 0.65 69.71 12.18 99.56
6 INT50673 Positive_regulation of Gene_expression of CPOX 156 0.54 97.31 37.03 98.40
7 INT60765 Gene_expression of LAMB2 28 0.49 13.93 2.38 91.00
8 INT263824 Positive_regulation of LOX 4 0.34 5.28 0.27 90.56
9 INT299845 Positive_regulation of TMEM200B 1 0.40 3.45 0.47 90.28
10 INT74272 Localization of CPOX 39 0.63 25.12 10.53 89.72
11 INT134859 Gene_expression of Lama5 3 0.39 4.47 1.06 88.40
12 INT111476 Gene_expression of TP63 88 0.76 61.08 11.64 87.32
13 INT101590 Gene_expression of SERPINB5 8 0.75 9.35 1.19 87.32
14 INT90674 Negative_regulation of LOX 56 0.57 38.01 8.58 86.44
15 INT279432 Positive_regulation of Negative_regulation of ACTR1B 1 0.27 2.06 0.06 85.88
16 INT279425 Negative_regulation of Binding of ACTR1B 1 0.16 1.86 0.12 85.84
17 INT205165 Negative_regulation of ACTR1B 5 0.22 4.94 0.37 85.40
18 INT205179 Binding of ACTR1B 2 0.17 2.17 0.12 85.36
19 INT249732 Gene_expression of Itgb6 1 0.03 10.37 2.63 84.40
20 INT73625 Gene_expression of PPARG 108 0.78 104.85 21.42 83.92
21 INT94388 Gene_expression of GDF15 124 0.77 79.48 31.42 83.16
22 INT94390 Positive_regulation of Gene_expression of GDF15 67 0.69 45.5 14.74 83.16
23 INT279434 Positive_regulation of Negative_regulation of LOX 1 0.30 1.85 0.11 82.64
24 INT86024 Gene_expression of PPARA 736 0.78 497.93 91.14 81.36
25 INT249733 Protein_catabolism of Itgb6 1 0.03 5.77 2.99 78.88
26 INT66226 Positive_regulation of Gene_expression of COX18 10 0.31 4.41 2.11 75.12
27 INT100040 Positive_regulation of Gene_expression of Tsu 1 0.08 0.82 0.15 75.12
28 INT9886 Gene_expression of Ptgs1 92 0.77 40.66 25.31 75.00
29 INT100139 Positive_regulation of Gene_expression of PPARA 160 0.63 97.78 14.53 73.24
30 INT100044 Regulation of BTG2 3 0.23 1.78 1.2 71.60
31 INT100043 Regulation of COX18 3 0.08 1.08 0.35 71.60
32 INT100045 Regulation of Gene_expression of COX18 2 0.09 0.8 0.15 71.60
33 INT100047 Regulation of SYCP2L 1 0.02 0.8 0.15 71.60
34 INT100039 Regulation of Tsu 1 0.08 0.8 0.15 71.60
35 INT49750 Negative_regulation of CPOX 735 0.58 360.06 274.19 71.52
36 INT89240 Gene_expression of VEGFC 23 0.75 15.94 2.03 71.12
37 INT245298 Negative_regulation of VEGFC 3 0.42 3.66 0.16 71.12
38 INT102249 Binding of HIF1A 39 0.36 30.47 1.04 70.32
39 INT66227 Gene_expression of COX18 41 0.50 26.91 6.26 70.24
40 INT100046 Gene_expression of BTG2 16 0.20 10.81 1.95 70.24
41 INT100042 Gene_expression of SYCP2L 2 0.02 1.36 0.15 70.24
42 INT100041 Gene_expression of Tsu 1 0.10 0.74 0.15 70.24
43 INT282448 Protein_catabolism of Gabra6 1 0.14 1 0 69.76
44 INT207746 Gene_expression of AMACR 3 0.75 2.83 0.04 67.84
45 INT201216 Negative_regulation of LAMB2 6 0.04 3.75 0.71 67.68
46 INT173159 Localization of PPARA 96 0.74 64.55 10.26 65.20
47 INT169318 Positive_regulation of Rxra 15 0.42 4.35 2.12 63.04
48 INT67613 Positive_regulation of PPARG 94 0.70 69.15 34.38 60.60
49 INT69322 Negative_regulation of MAPK14 70 0.54 42.92 22.71 60.36
50 INT4756 Positive_regulation of Nrtim1 37 0.33 14.6 24.12 60.36
51 INT73626 Positive_regulation of Gene_expression of PPARG 22 0.70 18.82 4.4 59.84
52 INT39153 Positive_regulation of PTGS2 182 0.70 96.16 60.6 57.32
53 INT93758 Transcription of COX18 4 0.34 2.73 0.34 57.20
54 INT105387 Gene_expression of HIF1A 116 0.77 98.62 14.66 56.80
55 INT105390 Positive_regulation of Gene_expression of HIF1A 27 0.49 26.3 2.88 56.80
56 INT84685 Regulation of BCL2 67 0.60 72.96 6.65 53.08
57 INT31116 Gene_expression of Casp3 192 0.78 78.21 57.43 50.00
58 INT106525 Phosphorylation of Akt1 436 0.82 183.81 47.82 50.00
59 INT52531 Gene_expression of Nfkb1 153 0.75 82.84 42.9 50.00
60 INT77307 Gene_expression of Bcl2 399 0.77 319.77 38 50.00
61 INT114881 Gene_expression of Akt1 227 0.78 102.49 31.81 50.00
62 INT78694 Positive_regulation of Gene_expression of Casp3 46 0.66 18.64 19.62 50.00
63 INT28215 Gene_expression of CDKN1A 196 0.76 113.9 18.3 50.00
64 INT93361 Gene_expression of Trp53 208 0.78 175.35 16.65 50.00
65 INT109535 Gene_expression of Vegfa 116 0.75 84.61 14.89 50.00
66 INT109511 Gene_expression of Bax 133 0.78 113.22 14.36 50.00
67 INT81640 Positive_regulation of Gene_expression of Bcl2 106 0.69 84.58 11.63 50.00
68 INT111533 Positive_regulation of Gene_expression of Nfkb1 27 0.52 17.32 7.89 50.00
69 INT97055 Positive_regulation of Gene_expression of Trp53 51 0.70 45.7 7.25 50.00
70 INT114882 Positive_regulation of Gene_expression of Akt1 45 0.69 21.29 6.06 50.00
71 INT88873 Negative_regulation of Gene_expression of Nfkb1 24 0.56 9.93 5.97 50.00
72 INT109513 Positive_regulation of Gene_expression of Bax 37 0.67 29.52 5.06 50.00
73 INT109972 Phosphorylation of Trp53 13 0.80 6.15 4.68 50.00
74 INT55171 Gene_expression of RELA 80 0.75 17.17 4.47 50.00
75 INT71882 Phosphorylation of Nfkb1 20 0.81 11.46 4.1 50.00
76 INT123528 Negative_regulation of Gene_expression of Vegfa 10 0.57 7.08 2.31 50.00
77 INT123530 Phosphorylation of RELA 9 0.80 3.46 1.99 50.00
78 INT98782 Gene_expression of Cdkn1b 70 0.75 36.43 1.9 50.00
79 INT118833 Positive_regulation of Gene_expression of Vegfa 11 0.65 8.14 1.7 50.00
80 INT110252 Positive_regulation of Gene_expression of RELA 29 0.49 6.36 1.31 50.00
81 INT98786 Positive_regulation of Gene_expression of Cdkn1b 21 0.67 8.7 0.56 50.00
82 INT123529 Phosphorylation of CDKN1A 8 0.80 5.69 0.29 50.00
83 INT123520 Gene_expression of Ar 12 0.32 6.98 0.25 50.00
84 INT123527 Negative_regulation of Gene_expression of Ar 2 0.10 0 0.14 50.00
85 INT123522 Phosphorylation of Casp3 3 0.80 1.36 0.14 50.00
86 INT123525 Phosphorylation of Bax 3 0.41 1.18 0.03 50.00
87 INT123526 Positive_regulation of Gene_expression of Ar 2 0.11 1.29 0 50.00
88 INT123521 Phosphorylation of Bcl2 8 0.81 5 0 50.00
89 INT123524 Phosphorylation of Cdkn1b 4 0.29 2.29 0 50.00
90 INT123518 Negative_regulation of Aktip 1 0.06 0 0 50.00
91 INT123523 Phosphorylation of Vegfa 1 0.35 0.07 0 50.00
92 INT123519 Negative_regulation of Phosphorylation of Aktip 1 0.04 0 0 50.00
93 INT123517 Phosphorylation of Aktip 1 0.08 0 0 50.00
94 INT123516 Phosphorylation of Ar 1 0.19 0.07 0 50.00
95 INT67614 Positive_regulation of PPARA 438 0.68 293.28 63.61 49.16
96 INT28361 Gene_expression of TP53 443 0.78 384.86 28.8 42.76
97 INT100379 Positive_regulation of HIF1A 69 0.69 57.31 10.4 39.12
98 INT84572 Gene_expression of Zmat3 67 0.07 37.61 5.86 36.84
99 INT103924 Positive_regulation of Akt1 359 0.69 158.94 60.34 36.16
100 INT118610 Localization of BPHL 6 0.57 6.88 0.33 35.84
101 INT101992 Localization of VEGFA 413 0.81 258.23 36.15 32.80
102 INT143443 Localization of HIF1A 14 0.78 10.93 1.49 32.80
103 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 32.16
104 INT28951 Negative_regulation of IGF1 133 0.59 75.77 18.9 27.24
105 INT103096 Regulation of PPARA 113 0.60 62.47 14.57 26.16
106 INT115196 Localization of IL4I1 3 0.24 1.47 0.47 25.60
107 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 21.28
108 INT100381 Positive_regulation of Positive_regulation of HIF1A 12 0.49 12.05 2.17 21.28
109 INT101517 Negative_regulation of PPARA 168 0.57 112.24 21.41 20.52
110 INT105392 Positive_regulation of Binding of HIF1A 5 0.45 3.83 0.1 18.52
111 INT155352 Phosphorylation of HIF1A 3 0.79 3.34 0.83 18.00
112 INT48692 Binding of VEGFA 345 0.48 210.3 21.31 17.56
113 INT121496 Gene_expression of TERT 107 0.78 45.6 7.42 15.00
114 INT276227 Gene_expression of UBL4A 9 0.20 7.12 0.64 9.68
115 INT173098 Positive_regulation of Negative_regulation of VHLL 1 0.07 0.6 0.04 5.44
116 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 5.00
117 INT62124 Gene_expression of NOS1 444 0.78 218.08 114.85 5.00
118 INT48593 Positive_regulation of NOS1 420 0.68 226.15 114.71 5.00
119 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 5.00
120 INT10838 Positive_regulation of IL8 381 0.70 295.51 101.62 5.00
121 INT7944 Positive_regulation of Fos 193 0.70 60.69 98.31 5.00
122 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 5.00
123 INT10837 Positive_regulation of Gene_expression of IL8 294 0.70 190.08 70.34 5.00
124 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07 5.00
125 INT9196 Gene_expression of PTGS1 215 0.77 96.99 60.5 5.00
126 INT103094 Binding of PPARA 308 0.47 177.26 34.75 5.00
127 INT64171 Regulation of CPOX 109 0.36 55.36 32.96 5.00
128 INT48693 Regulation of VEGFA 268 0.62 191.88 31.52 5.00
129 INT64113 Positive_regulation of Gene_expression of NOS1 110 0.60 71.03 29.72 5.00
130 INT6855 Binding of NCOR2 71 0.41 15.64 28.96 5.00
131 INT2389 Regulation of PTGS1 86 0.61 31.23 28.95 5.00
132 INT5206 Gene_expression of AR 316 0.78 113.83 27.29 5.00
133 INT14690 Localization of CSF2 124 0.80 85.17 27.26 5.00
134 INT16428 Positive_regulation of Gtf3a 135 0.20 106.44 26.67 5.00
135 INT2614 Gene_expression of CGA 187 0.78 105.89 24.77 5.00
136 INT27933 Gene_expression of NCOR2 65 0.72 31.35 24.23 5.00
137 INT64175 Negative_regulation of Gene_expression of CPOX 66 0.38 39.64 23.07 5.00
138 INT28950 Positive_regulation of Gene_expression of IGF1 99 0.69 46.9 16.47 5.00
139 INT7970 Gene_expression of PLOD1 120 0.71 44.42 15.54 5.00
140 INT16166 Positive_regulation of DMD 348 0.67 133.22 15.06 5.00
141 INT18012 Gene_expression of EPO 169 0.78 108.36 13.75 5.00
142 INT86383 Negative_regulation of EGFR 258 0.59 173.94 13.32 5.00
143 INT91817 Positive_regulation of RETNLB 22 0.34 21.4 13.12 5.00
144 INT4145 Gene_expression of FSHR 124 0.77 44.98 13.04 5.00
145 INT127022 Gene_expression of Lts1 43 0.23 28.29 12.64 5.00
146 INT114274 Gene_expression of Rxra 67 0.70 36.77 12.5 5.00
147 INT14510 Gene_expression of SOD1 208 0.76 88.56 12.4 5.00
148 INT1735 Gene_expression of HSD11B1 199 0.75 257.87 11.5 5.00
149 INT20603 Positive_regulation of TNFRSF10B 40 0.67 32.61 11.44 5.00
150 INT1734 Negative_regulation of HSD11B1 116 0.57 125.13 10.52 5.00
151 INT144391 Gene_expression of RETN 42 0.75 40.48 10.47 5.00
152 INT134625 Gene_expression of Kdr 116 0.71 53.13 10.09 5.00
153 INT122584 Negative_regulation of Gene_expression of PPARA 56 0.58 37.61 9.76 5.00
154 INT70134 Negative_regulation of TXK 124 0.23 81.96 9.59 5.00
155 INT144430 Gene_expression of Erbb2 137 0.77 103.87 8.66 5.00
156 INT36798 Gene_expression of Mki67 178 0.77 132 8.24 5.00
157 INT53487 Gene_expression of TSC1 81 0.58 77.71 7.94 5.00
158 INT15012 Regulation of Gpi1 18 0.60 11.64 6.91 5.00
159 INT50387 Negative_regulation of AR 67 0.45 26.31 6.61 5.00
160 INT17913 Regulation of HSD11B1 87 0.60 93.23 6.04 5.00
161 INT39758 Gene_expression of Fn1 57 0.65 34.38 6.02 5.00
162 INT181194 Regulation of Gene_expression of PPARA 31 0.44 21.27 5.96 5.00
163 INT111545 Phosphorylation of VEGFA 50 0.76 22.19 5.88 5.00
164 INT64888 Negative_regulation of HBM 52 0.16 34.33 5.45 5.00
165 INT181186 Binding of Rxra 78 0.35 14.93 4.87 5.00
166 INT156850 Binding of VDR 40 0.47 24.86 4.87 5.00
167 INT100772 Negative_regulation of TXNRD1 10 0.41 3.47 4.74 5.00
168 INT8340 Negative_regulation of SHBG 49 0.57 35.96 4.73 5.00
169 INT119203 Gene_expression of CXADR 64 0.74 11.37 4.41 5.00
170 INT103155 Gene_expression of KDR 78 0.66 50.53 4.38 5.00
171 INT79692 Negative_regulation of PPARG 24 0.59 16 4.31 5.00
172 INT7083 Positive_regulation of HBM 35 0.66 20.96 4.3 5.00
173 INT10374 Gene_expression of RARA 39 0.75 22.59 4.28 5.00
174 INT90890 Positive_regulation of RARA 25 0.67 9.32 4.2 5.00
175 INT34720 Positive_regulation of SHBG 58 0.69 32.4 3.83 5.00
176 INT16165 Regulation of DMD 114 0.60 35.13 3.64 5.00
177 INT73463 Positive_regulation of Gene_expression of TSC1 20 0.38 14.59 3.53 5.00
178 INT87517 Gene_expression of LDLR 73 0.69 37.35 3.32 5.00
179 INT112365 Regulation of HIF1A 27 0.60 21.24 3.05 5.00
180 INT99187 Negative_regulation of Positive_regulation of PPARG 5 0.42 5.07 2.99 5.00
181 INT16616 Negative_regulation of SRD5A1 44 0.57 34.81 2.96 5.00
182 INT130080 Negative_regulation of Rxra 6 0.53 2.08 2.92 5.00
183 INT222961 Negative_regulation of Binding of PPARA 22 0.41 10.76 2.72 5.00
184 INT108555 Positive_regulation of HK2 5 0.29 4.91 2.62 5.00
185 INT31989 Binding of SOD1 43 0.47 19.38 2.55 5.00
186 INT97902 Gene_expression of AGGF1 17 0.11 13.45 2.51 5.00
187 INT141745 Gene_expression of SPNS1 5 0.67 3.55 2.44 5.00
188 INT249731 Negative_regulation of Protein_catabolism of Itgb6 1 0.02 3.6 2.36 5.00
189 INT22679 Binding of SERPINE1 25 0.36 17.33 2.36 5.00
190 INT134626 Positive_regulation of Gene_expression of Kdr 20 0.63 14.63 2.29 5.00
191 INT60279 Gene_expression of VHL 70 0.78 75.21 2.21 5.00
192 INT173090 Regulation of INCENP 24 0.09 9.45 2.16 5.00
193 INT35058 Positive_regulation of PLAUR 11 0.61 7.21 2.16 5.00
194 INT57501 Binding of CREM 11 0.27 3.67 2.15 5.00
195 INT112364 Negative_regulation of HIF1A 22 0.57 16.95 2.13 5.00
196 INT56925 Negative_regulation of TSC1 54 0.52 63.39 1.87 5.00
197 INT79691 Regulation of Gene_expression of PPARG 10 0.50 10.44 1.62 5.00
198 INT79690 Negative_regulation of Gene_expression of PPARG 10 0.59 10.48 1.55 5.00
199 INT119048 Negative_regulation of Gene_expression of HIF1A 10 0.57 9.23 1.5 5.00
200 INT173198 Regulation of Binding of PPARA 17 0.43 9.58 1.47 5.00
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