D:Protein Deficiency

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Disease Term
Synonyms Deficiencies Protein, Deficiency Protein, PROTEIN DEFICIENCIES
Documents 32
Hot Single Events 19
Hot Interactions 1

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Protein Deficiency. They are ordered first by their relevance to Protein Deficiency and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT340379 Binding of Rabep1 and Ocrl 1 0.08 0.62 0 92.32
2 INT173477 Bcar1 Regulation of Localization of Ins1 1 0.16 0.07 0.05 70.32
3 INT315533 Negative_regulation of GLRX5 Negative_regulation of Gene_expression of ALAS2 1 0.38 1.06 0 38.36
4 INT315538 Negative_regulation of GLRX5 Negative_regulation of Gene_expression of SLC40A1 1 0.25 1.14 0 38.36
5 INT288731 Binding of Got1 and Gpt 1 0.23 1.25 1.61 5.00
6 INT288729 Positive_regulation of Binding of Got1 and Gpt 1 0.25 0.61 0.49 5.00
7 INT173475 Bcar1 Regulation of Isl1 1 0.01 0 0.47 5.00
8 INT347563 Abat Positive_regulation of Gopc 1 0.04 0.2 0.43 5.00
9 INT237471 Ltp Regulation of Bdnf 1 0.02 0.13 0.42 5.00
10 INT173476 Th Regulation of Gene_expression of Bcar1 1 0.10 0 0.34 5.00
11 INT173478 Th Regulation of Localization of Ins1 1 0.13 0 0.34 5.00
12 INT347562 Abat Positive_regulation of Mki67 1 0.03 0 0.3 5.00
13 INT288732 Got1 Positive_regulation of Gene_expression of Gpt 1 0.31 0.52 0.23 5.00
14 INT289293 Binding of CD59 and Cd33 1 0.02 1.06 0 5.00
15 INT315543 NARFL Regulation of Gene_expression of HIF1A 1 0.01 0.63 0 5.00
16 INT289301 Binding of CD59 and Cd24a 1 0.02 1.06 0 5.00
17 INT315541 ACO1 Negative_regulation of Gene_expression of ALAS2 1 0.17 0.18 0 5.00
18 INT315534 Binding of ACO1 and ERN1 1 0.01 0.18 0 5.00
19 INT340380 Binding of Cfl1 and Clcn4-2 1 0.13 0.82 0 5.00
20 INT289296 Binding of CD59 and C6 1 0.02 0.5 0 5.00
21 INT289295 Binding of CD59 and Fcgr3 1 0.01 1.06 0 5.00
22 INT289297 Negative_regulation of Binding of CD59 and C6 1 0.02 0.51 0 5.00
23 INT289300 Binding of CD59 and Fut4 1 0.01 1.06 0 5.00
24 INT289294 Binding of CD59 and Atp6ap1 1 0.10 0.51 0 5.00
25 INT340378 Binding of Cfl1 and Clcn5 1 0.15 0.82 0 5.00
26 INT315535 Binding of ABCB7 and FECH 1 0.28 0.7 0 5.00
27 INT289299 Binding of CD59 and Cd14 1 0.02 1.06 0 5.00
28 INT289298 Negative_regulation of Binding of CD59 and Atp6ap1 1 0.12 0.51 0 5.00
29 INT315532 Binding of NFS1 and ISCU 1 0.19 0.37 0 5.00
30 INT340377 Binding of Clcn4-2 and Clcn5 1 0.35 0.82 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Protein Deficiency. They are ordered first by their pain relevance and then by number of times they were reported in Protein Deficiency. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT315562 Gene_expression of GLRX5 1 0.69 4.92 0 100.00
2 INT315607 Positive_regulation of Gene_expression of GLRX5 1 0.61 2.28 0 100.00
3 INT2364 Localization of Sct 134 0.80 26.21 41.47 99.62
4 INT1474 Regulation of Localization of Ins1 132 0.61 25.96 43.07 99.46
5 INT7475 Positive_regulation of Hdl1 138 0.67 175.81 15.05 98.44
6 INT1988 Positive_regulation of Localization of Ins1 254 0.69 59.25 68.37 98.38
7 INT1114 Localization of Ins1 748 0.80 192.95 165.48 98.22
8 INT315613 Positive_regulation of WNT2 1 0.09 0.41 0 95.16
9 INT315604 Negative_regulation of Positive_regulation of WNT2 1 0.08 0.41 0 95.16
10 INT162471 Positive_regulation of ERN1 7 0.34 3.02 1.08 92.76
11 INT340374 Binding of Rabep1 1 0.05 0.61 0 92.32
12 INT122557 Localization of Chdh 6 0.74 4.44 2.6 91.92
13 INT2604 Positive_regulation of Got1 223 0.70 154.78 49.51 91.84
14 INT340368 Binding of Ocrl 1 0.37 2.61 0 90.00
15 INT3286 Positive_regulation of Gpt 90 0.69 45.08 28.34 88.16
16 INT22909 Positive_regulation of Chdh 26 0.68 28.69 16.13 88.12
17 INT340370 Negative_regulation of Ocrl 1 0.43 2.31 0 83.96
18 INT217 Negative_regulation of Th 134 0.59 26.83 62.63 81.04
19 INT2276 Regulation of Ins1 234 0.61 103.78 54.05 80.08
20 INT237470 Negative_regulation of Localization of Car1 1 0.32 0.26 0.43 77.16
21 INT82841 Localization of Car1 11 0.68 3.91 2.84 76.24
22 INT12029 Gene_expression of Car1 143 0.67 29.69 36.39 75.24
23 INT125444 Gene_expression of Rora 5 0.75 3.05 8.97 75.00
24 INT125442 Negative_regulation of Gene_expression of Rora 5 0.57 2.92 2.54 75.00
25 INT49759 Negative_regulation of CETP 43 0.58 52 2.68 75.00
26 INT8640 Positive_regulation of HSD11B1 332 0.67 377.84 22.36 75.00
27 INT70647 Regulation of CETP 7 0.61 4.53 0.21 75.00
28 INT116725 Positive_regulation of CETP 19 0.49 16.33 0.36 75.00
29 INT125443 Negative_regulation of Rora 1 0.57 0.74 0.08 75.00
30 INT7628 Gene_expression of Ltp 273 0.77 70.21 147.87 70.72
31 INT243267 Positive_regulation of SLC40A1 4 0.41 2.72 0.22 69.00
32 INT243268 Gene_expression of SLC40A1 6 0.60 4.18 0.13 68.48
33 INT315591 Negative_regulation of Positive_regulation of SLC40A1 1 0.25 0.46 0 68.48
34 INT315559 Negative_regulation of CIAO1 1 0.19 2.53 0 65.88
35 INT315621 Gene_expression of CIAO1 1 0.34 4.11 0 65.88
36 INT315620 Regulation of Gene_expression of GLRX5 1 0.40 0.5 0 64.44
37 INT3657 Gene_expression of Ins1 514 0.78 321.69 75.76 62.40
38 INT7114 Positive_regulation of Ltp 1192 0.62 290.76 755.77 59.04
39 INT3323 Gene_expression of ALAS2 10 0.58 7.51 0.21 48.28
40 INT315606 Regulation of Gene_expression of WNT2 1 0.08 0.84 0 45.52
41 INT315593 Regulation of Transcription of SLC40A1 1 0.26 1.7 0 45.52
42 INT1472 Positive_regulation of Ins1 349 0.69 146.2 86.36 45.28
43 INT302084 Negative_regulation of WNT2 2 0.09 0.83 1.26 45.08
44 INT302086 Gene_expression of WNT2 3 0.14 0.97 0.38 45.08
45 INT315575 Transcription of SLC40A1 1 0.40 0.85 0 43.88
46 INT47690 Regulation of Bdnf 118 0.62 53.02 64.5 43.28
47 INT315552 Negative_regulation of GLRX5 1 0.38 2.17 0 38.36
48 INT315551 Negative_regulation of Gene_expression of ALAS2 1 0.37 1.11 0 35.72
49 INT3322 Positive_regulation of Gene_expression of ALAS2 4 0.43 3.25 0 35.72
50 INT2211 Negative_regulation of Abat 267 0.59 66.51 200.98 35.12
51 INT315592 Positive_regulation of Gene_expression of SLC40A1 1 0.41 3.52 0 33.52
52 INT315565 Negative_regulation of Gene_expression of SLC40A1 1 0.25 1.73 0 32.64
53 INT315567 Positive_regulation of Negative_regulation of CIAO1 1 0.22 1.29 0 28.44
54 INT16260 Gene_expression of Bdnf 671 0.78 283.44 339.1 27.04
55 INT16253 Positive_regulation of Gene_expression of Bdnf 196 0.70 92.67 113.01 27.04
56 INT57192 Binding of Ltp 43 0.41 17.48 24.96 25.00
57 INT4740 Gene_expression of Th 298 0.78 61.27 154.03 22.64
58 INT6558 Positive_regulation of Gene_expression of Th 56 0.70 9.64 30.89 22.64
59 INT218 Positive_regulation of Th 245 0.70 40.5 120.1 21.84
60 INT3439 Localization of Abat 1017 0.78 112.39 727.06 5.00
61 INT2909 Positive_regulation of Abat 334 0.70 62.1 256.43 5.00
62 INT9987 Gene_expression of Abat 296 0.78 95.46 226.34 5.00
63 INT16259 Positive_regulation of Bdnf 336 0.70 183.48 209.82 5.00
64 INT2391 Negative_regulation of PTGS1 501 0.59 207.62 205.6 5.00
65 INT6354 Localization of Gabrg1 321 0.74 41.41 186.74 5.00
66 INT7506 Negative_regulation of Ltp 267 0.46 91.01 176.8 5.00
67 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 5.00
68 INT9852 Positive_regulation of Gpt 563 0.70 364.64 146.82 5.00
69 INT812 Localization of INS 1026 0.81 515.6 145.31 5.00
70 INT14843 Gene_expression of Gabrg1 301 0.77 62.63 139.16 5.00
71 INT6323 Positive_regulation of Gabrg1 213 0.70 45.08 124.34 5.00
72 INT170025 Gene_expression of Fig4 588 0.67 183.27 113.32 5.00
73 INT7327 Regulation of Th 164 0.62 29.67 110.14 5.00
74 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 5.00
75 INT67682 Localization of Bdnf 204 0.81 72.36 88.92 5.00
76 INT13276 Regulation of Ltp 107 0.53 30.78 69.13 5.00
77 INT2212 Binding of Abat 89 0.48 18.36 63.99 5.00
78 INT17564 Gene_expression of Gpt 322 0.75 208.51 60.36 5.00
79 INT546 Binding of ALB 311 0.48 85.98 60.14 5.00
80 INT47680 Regulation of Gene_expression of Bdnf 92 0.62 41.61 53.24 5.00
81 INT16850 Negative_regulation of Localization of Gabrg1 73 0.51 8.28 47.89 5.00
82 INT1322 Positive_regulation of Localization of INS 293 0.70 120.86 45.98 5.00
83 INT2275 Negative_regulation of Localization of Ins1 183 0.59 51.02 44.94 5.00
84 INT26788 Gene_expression of Gad1 93 0.78 27.05 42.71 5.00
85 INT350 Localization of Th 79 0.80 10.26 41.17 5.00
86 INT16261 Transcription of Bdnf 101 0.72 49.41 40.64 5.00
87 INT69437 Positive_regulation of ROS1 328 0.58 222.83 40.56 5.00
88 INT12228 Positive_regulation of Gene_expression of Abat 44 0.65 17.51 40.55 5.00
89 INT3252 Negative_regulation of INS 428 0.59 271.65 39.52 5.00
90 INT173693 Localization of Gopc 249 0.65 70.49 38.81 5.00
91 INT2274 Regulation of Localization of INS 101 0.62 41.55 34.79 5.00
92 INT15610 Localization of GOPC 223 0.65 68.26 28.7 5.00
93 INT67620 Negative_regulation of Gene_expression of Bdnf 53 0.59 22.45 28.5 5.00
94 INT54467 Localization of Ltp 41 0.58 8.86 26.88 5.00
95 INT32826 Positive_regulation of Gene_expression of Ltp 52 0.45 10.34 26.8 5.00
96 INT20044 Negative_regulation of Gpi1 50 0.59 29.96 26 5.00
97 INT13145 Positive_regulation of Car1 60 0.70 16.32 23.23 5.00
98 INT5096 Positive_regulation of Gtf3a 79 0.60 42.26 20.62 5.00
99 INT12031 Negative_regulation of Car1 44 0.59 20.46 19.36 5.00
100 INT10565 Gene_expression of MRXS5 94 0.53 37.35 19.08 5.00
101 INT56749 Gene_expression of PCNA 219 0.77 111.25 18.42 5.00
102 INT14587 Positive_regulation of Cl 44 0.20 20.37 16.72 5.00
103 INT170033 Positive_regulation of Gene_expression of Fig4 59 0.43 20.99 16.69 5.00
104 INT96299 Positive_regulation of Localization of Bdnf 35 0.70 15.67 16.09 5.00
105 INT171666 Regulation of GOPC 117 0.39 40.41 15.47 5.00
106 INT105387 Gene_expression of HIF1A 116 0.77 98.62 14.66 5.00
107 INT37430 Gene_expression of Gpi1 61 0.63 54.63 13.87 5.00
108 INT8210 Positive_regulation of Gene_expression of INS 188 0.68 146.57 12.83 5.00
109 INT21987 Positive_regulation of Rorb 30 0.33 12.7 12.24 5.00
110 INT56048 Positive_regulation of Transcription of Bdnf 24 0.70 8.33 11.83 5.00
111 INT192967 Gene_expression of Hp 14 0.43 8.06 11.01 5.00
112 INT54466 Negative_regulation of Gene_expression of Ltp 19 0.38 5.44 10.91 5.00
113 INT3851 Gene_expression of Got1 58 0.65 29.15 10.52 5.00
114 INT3287 Gene_expression of Gpt 50 0.75 23.69 8.57 5.00
115 INT15805 Gene_expression of TFRC 35 0.75 17.44 8.52 5.00
116 INT25152 Gene_expression of SAA1 37 0.75 53.56 8.07 5.00
117 INT12028 Regulation of Car1 28 0.43 9.01 7.84 5.00
118 INT4606 Regulation of Gene_expression of INS 67 0.61 54.69 7.53 5.00
119 INT90097 Localization of PTGS2 15 0.69 6.14 6.63 5.00
120 INT4208 Regulation of Got1 23 0.44 6.72 6.62 5.00
121 INT6891 Binding of TTR 72 0.48 22.81 6.51 5.00
122 INT56374 Gene_expression of AMBP 34 0.54 35.85 6.25 5.00
123 INT8106 Gene_expression of GGT1 31 0.75 18.65 6.1 5.00
124 INT41892 Gene_expression of HBM 48 0.64 28.32 5.64 5.00
125 INT131944 Gene_expression of Mki67 30 0.53 6.58 5.63 5.00
126 INT12030 Positive_regulation of Gene_expression of Car1 15 0.50 3.98 5.27 5.00
127 INT146488 Gene_expression of Slc12a2 16 0.73 4.63 5.11 5.00
128 INT2072 Localization of AMBP 33 0.65 37.58 4.84 5.00
129 INT80486 Gene_expression of FECH 13 0.54 10.42 4.8 5.00
130 INT18639 Positive_regulation of OAP 16 0.69 10.49 4.57 5.00
131 INT26787 Localization of Uchl1 10 0.60 5.9 4.48 5.00
132 INT272273 Gene_expression of NARFL 89 0.54 121.19 4.47 5.00
133 INT7083 Positive_regulation of HBM 35 0.66 20.96 4.3 5.00
134 INT45975 Positive_regulation of SAA1 17 0.67 19.7 4.15 5.00
135 INT67138 Gene_expression of Gc 19 0.31 17.11 4.1 5.00
136 INT12189 Localization of Gpt 8 0.73 3.63 3.92 5.00
137 INT6507 Binding of C5 23 0.48 15.35 3.91 5.00
138 INT14880 Positive_regulation of Car3 14 0.65 9.19 3.73 5.00
139 INT69904 Binding of Hc 11 0.35 7.79 3.69 5.00
140 INT15801 Positive_regulation of TFRC 11 0.33 6.35 3.3 5.00
141 INT3919 Localization of Got1 10 0.71 2.95 3.28 5.00
142 INT78297 Gene_expression of CD59 31 0.72 24.11 3.18 5.00
143 INT31340 Positive_regulation of Gene_expression of Got1 20 0.46 10.5 3.17 5.00
144 INT32852 Negative_regulation of FECH 18 0.57 10.59 3.08 5.00
145 INT112365 Regulation of HIF1A 27 0.60 21.24 3.05 5.00
146 INT2135 Regulation of Gpt 13 0.44 2.17 3.03 5.00
147 INT74508 Gene_expression of Gypa 7 0.75 2.15 2.89 5.00
148 INT10267 Regulation of Positive_regulation of Ins1 11 0.24 2.74 2.63 5.00
149 INT155160 Binding of C3 20 0.47 7.77 2.61 5.00
150 INT182034 Binding of Gpi1 10 0.39 8.76 2.59 5.00
151 INT263088 Positive_regulation of Mki67 15 0.19 2.13 2.57 5.00
152 INT69290 Localization of Cftr 11 0.75 3.69 2.52 5.00
153 INT61378 Positive_regulation of Bcar1 13 0.45 2.84 2.45 5.00
154 INT243496 Positive_regulation of Gene_expression of FECH 4 0.40 4.02 2.34 5.00
155 INT57191 Negative_regulation of Binding of Ltp 4 0.34 0.81 2.24 5.00
156 INT56375 Positive_regulation of AMBP 25 0.60 21.24 2.22 5.00
157 INT44223 Positive_regulation of TTR 10 0.70 10.98 1.95 5.00
158 INT53567 Positive_regulation of FECH 14 0.45 11.03 1.82 5.00
159 INT210693 Positive_regulation of Gene_expression of Slc12a2 5 0.46 1.3 1.77 5.00
160 INT197374 Protein_catabolism of Ltp 4 0.57 0.43 1.73 5.00
161 INT23881 Gene_expression of Bcar1 8 0.52 2.48 1.69 5.00
162 INT173754 Regulation of Mki67 4 0.06 1.04 1.61 5.00
163 INT29777 Negative_regulation of CD59 16 0.42 14.88 1.56 5.00
164 INT192762 Localization of SAA1 10 0.78 12.63 1.44 5.00
165 INT15798 Positive_regulation of Gene_expression of TFRC 9 0.46 4.99 1.42 5.00
166 INT182035 Positive_regulation of Gene_expression of Gpi1 5 0.36 4.95 1.4 5.00
167 INT273128 Protein_catabolism of Hp 3 0.47 2.2 1.39 5.00
168 INT101653 Negative_regulation of SAA1 7 0.39 7 1.33 5.00
169 INT70615 Binding of TXNRD1 25 0.36 12.15 1.27 5.00
170 INT162467 Gene_expression of ERN1 10 0.56 5.11 1.26 5.00
171 INT47278 Positive_regulation of Positive_regulation of Car1 7 0.45 1.88 1.24 5.00
172 INT179372 Positive_regulation of Localization of PTGS2 2 0.38 0.35 1.21 5.00
173 INT57689 Localization of CD59 7 0.78 4.51 1.17 5.00
174 INT183046 Transcription of INS 25 0.70 11.14 1.13 5.00
175 INT115264 Binding of FECH 9 0.41 7.93 1.1 5.00
176 INT3288 Positive_regulation of Gene_expression of Gpt 9 0.49 5.55 1.1 5.00
177 INT76890 Gene_expression of FGFR2 42 0.65 13.91 1.08 5.00
178 INT36580 Positive_regulation of LCN1 9 0.45 5.63 1.02 5.00
179 INT15310 Gene_expression of DLEU1 8 0.67 20.57 0.96 5.00
180 INT4436 Gene_expression of ABCB7 7 0.65 9.26 0.93 5.00
181 INT263089 Positive_regulation of Gene_expression of Mki67 7 0.14 0.82 0.92 5.00
182 INT218315 Gene_expression of RBP4 25 0.76 18.19 0.85 5.00
183 INT173472 Positive_regulation of Isl1 1 0.03 0.2 0.83 5.00
184 INT347559 Gene_expression of Scgb1a1 1 0.16 0 0.77 5.00
185 INT225056 Positive_regulation of Gene_expression of AMBP 4 0.37 5.45 0.75 5.00
186 INT119933 Transcription of Car1 4 0.52 1.06 0.74 5.00
187 INT294932 Negative_regulation of Gc 6 0.17 3.38 0.71 5.00
188 INT190229 Gene_expression of Cd55 7 0.64 5 0.64 5.00
189 INT158136 Binding of FGFR2 9 0.26 4.5 0.63 5.00
190 INT94423 Binding of ALAS2 4 0.32 2.1 0.61 5.00
191 INT122737 Gene_expression of Daf2 6 0.69 2.11 0.61 5.00
192 INT219610 Protein_catabolism of SAA1 2 0.90 4.47 0.54 5.00
193 INT181965 Negative_regulation of Gene_expression of Gpi1 3 0.07 2.83 0.51 5.00
194 INT277912 Positive_regulation of Gene_expression of CD59 2 0.19 2.76 0.49 5.00
195 INT173474 Localization of Bcar1 2 0.35 0 0.47 5.00
196 INT173912 Negative_regulation of LRP2 5 0.57 6.22 0.42 5.00
197 INT347558 Localization of Scgb1a1 1 0.15 0.09 0.37 5.00
198 INT17937 Gene_expression of Isl1 4 0.27 0.48 0.36 5.00
199 INT56433 Negative_regulation of Cl 3 0.13 1.87 0.35 5.00
200 INT347554 Gene_expression of Mndal 1 0.01 0 0.35 5.00
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