D:Proteostasis Deficiencies

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Disease Term
Synonyms DEFICIENCIES PROTEOSTASIS, Deficiency Proteostasis, DISEASE PROTEIN FOLDING, Disease Protein Misfolding, DISEASES PROTEIN FOLDING, Diseases Protein Misfolding, DISORDER PROTEIN FOLDING, Disorder Protein Misfolding, Disorders Protein Folding, Disorders Protein Misfolding, Dysfunction Proteostasis
Documents 10
Hot Single Events 14
Hot Interactions 1

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Proteostasis Deficiencies. They are ordered first by their relevance to Proteostasis Deficiencies and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT308667 Binding of Chrm1 and Positive_regulation of Binding of App 1 0.04 1.14 0.32 80.04
2 INT322931 Binding of MOCS1 and Litaf 1 0.00 0.82 0 43.84
3 INT77646 Binding of Ngf and Ntrk1 23 0.40 7.85 9.26 5.00
4 INT106559 Binding of Bdnf and Ntrk2 23 0.43 11.09 7.33 5.00
5 INT88279 Ngf Positive_regulation of Ntrk1 5 0.76 3.06 5.23 5.00
6 INT165583 Binding of Bdnf and Ngf 3 0.33 0.81 0.69 5.00
7 INT308668 Akt1 Positive_regulation of Nos3 3 0.05 4.61 0.65 5.00
8 INT308656 Pik3r1 Positive_regulation of Nos3 1 0.02 1.8 0.5 5.00
9 INT197496 Binding of Apoe and Lrp1 4 0.22 2.32 0.46 5.00
10 INT308653 Proc Regulation of Gene_expression of Mapk8 1 0.00 1.48 0.36 5.00
11 INT255740 Pik3r1 Positive_regulation of Akt1 5 0.24 2.42 0.31 5.00
12 INT308661 Akt1 Positive_regulation of Chuk 1 0.02 0.6 0.25 5.00
13 INT308670 Positive_regulation of CYBB Positive_regulation of Gene_expression of Ros1 1 0.00 0.68 0.23 5.00
14 INT238802 Binding of Ager and Renbp 6 0.02 6.46 0.22 5.00
15 INT308650 Binding of nt and Ntrk2 1 0.01 0.41 0.21 5.00
16 INT308654 Binding of Ngfr and Nts 1 0.06 0.39 0.21 5.00
17 INT308645 Binding of Esr1 and Itpr3 1 0.00 0 0.2 5.00
18 INT308646 Car2 Regulation of Gene_expression of Ins1 1 0.00 0 0.19 5.00
19 INT308669 CREB1 Regulation of Gene_expression of Ins1 1 0.01 0 0.19 5.00
20 INT308657 Creb1 Regulation of Gene_expression of Ins1 1 0.01 0 0.19 5.00
21 INT308659 Binding of Ager and ecs 1 0.01 1.14 0.12 5.00
22 INT308647 Ager Positive_regulation of Gene_expression of Bace1 1 0.09 1.01 0.12 5.00
23 INT308660 Binding of Ager and App 1 0.08 1.22 0.12 5.00
24 INT308651 Binding of Igf1 and Ins1 1 0.02 0.22 0.11 5.00
25 INT308662 Binding of Esr1 and Fdft1 1 0.00 0.05 0.09 5.00
26 INT308666 Binding of Lrp1 and Chol1 1 0.10 0.69 0.09 5.00
27 INT308652 Binding of Renbp and Nps 1 0.01 1.38 0.09 5.00
28 INT308655 Binding of Lrp1 and Gopc 1 0.01 0.49 0.07 5.00
29 INT308665 Binding of Apoe and Gopc 1 0.02 0.49 0.07 5.00
30 INT308663 Apoe Regulation of Car2 1 0.02 0.44 0.07 5.00
31 INT308649 Binding of Ppp1r13b and Iars 1 0.01 0.29 0.04 5.00
32 INT308658 Binding of Apoa2 and Apoe 1 0.17 0.15 0.03 5.00
33 INT308648 Binding of sps and Gopc 1 0.01 2.71 0 5.00
34 INT308643 Binding of Proc and Renbp 1 0.00 1.61 0 5.00
35 INT308664 Akt1 Positive_regulation of Phosphorylation of Insr 1 0.02 0.43 0 5.00
36 INT121225 Positive_regulation of Ngf Positive_regulation of Ntrk1 2 0.49 0 0 5.00
37 INT354482 Binding of PRNP and Prnp 1 0.16 0.88 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Proteostasis Deficiencies. They are ordered first by their pain relevance and then by number of times they were reported in Proteostasis Deficiencies. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT749 Gene_expression of HLA-B 341 0.75 224.12 77.37 99.76
2 INT69570 Binding of Prnp 75 0.48 44.26 4.37 99.40
3 INT1876 Positive_regulation of HLA-B 82 0.69 52.16 21.08 96.48
4 INT102255 Regulation of Prnp 35 0.62 18.97 3.25 92.04
5 INT100601 Localization of PRNP 17 0.66 13.61 0.71 90.64
6 INT293049 Positive_regulation of Localization of PRNP 1 0.07 2.67 0.09 90.64
7 INT65500 Gene_expression of App 605 0.78 429.94 98.31 90.28
8 INT3982 Gene_expression of Acot1 53 0.56 7.61 10.46 88.60
9 INT3217 Regulation of Ins1 154 0.62 87.11 27.29 86.44
10 INT87765 Binding of Acot1 4 0.07 2.59 0.95 85.64
11 INT162741 Binding of Scap 1 0.00 0.51 0.16 83.92
12 INT41490 Regulation of Acot1 14 0.45 1.59 3.34 83.68
13 INT102112 Gene_expression of Prnp 440 0.78 209.32 22.5 80.88
14 INT33170 Binding of Chrm1 11 0.48 1.58 2.1 80.04
15 INT35284 Positive_regulation of Chrm1 14 0.67 5.64 10.11 79.16
16 INT69572 Localization of Prnp 96 0.81 38.11 5.45 78.88
17 INT16794 Binding of App 103 0.48 64.87 19.79 76.88
18 INT241797 Gene_expression of CHIT1 10 0.24 9.75 0.69 69.52
19 INT241798 Negative_regulation of Gene_expression of CHIT1 4 0.15 2.07 0.1 69.52
20 INT241799 Negative_regulation of CHIT1 13 0.42 4.37 0.44 68.96
21 INT159718 Negative_regulation of Gene_expression of Acot1 4 0.16 1.4 1.56 66.00
22 INT204737 Negative_regulation of Gene_expression of Prnp 32 0.59 18.96 1.03 60.32
23 INT102253 Negative_regulation of Prnp 75 0.59 24.23 2.62 60.32
24 INT107341 Phosphorylation of MAPT 19 0.80 14 1.61 52.20
25 INT68297 Binding of MAPT 9 0.47 4.45 0.75 52.20
26 INT178338 Gene_expression of Tbx15 50 0.65 38.65 12.19 40.40
27 INT293048 Regulation of Protein_catabolism of PRNP 1 0.06 1.01 0 35.84
28 INT293047 Protein_catabolism of PRNP 1 0.57 2 0.03 35.44
29 INT64113 Positive_regulation of Gene_expression of NOS1 110 0.60 71.03 29.72 28.56
30 INT62124 Gene_expression of NOS1 444 0.78 218.08 114.85 28.16
31 INT97453 Negative_regulation of MOCS1 25 0.04 13.4 2.4 27.12
32 INT292776 Positive_regulation of Brsk1 3 0.03 1.28 0.13 22.16
33 INT108246 Regulation of Renbp 5 0.21 4.66 1.12 15.76
34 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
35 INT7114 Positive_regulation of Ltp 1192 0.62 290.76 755.77 5.00
36 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
37 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 5.00
38 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 5.00
39 INT95787 Positive_regulation of Mapk1 568 0.70 226.51 220.94 5.00
40 INT24326 Gene_expression of Ngf 346 0.78 218.67 184.71 5.00
41 INT7506 Negative_regulation of Ltp 267 0.46 91.01 176.8 5.00
42 INT19472 Gene_expression of Il1 554 0.76 419.75 175.35 5.00
43 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 5.00
44 INT64161 Positive_regulation of Prkca 213 0.70 85.06 129.91 5.00
45 INT92669 Gene_expression of Bdnf 309 0.78 178.26 116.68 5.00
46 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 5.00
47 INT49171 Gene_expression of Nos1 241 0.78 140.7 104.76 5.00
48 INT3537 Positive_regulation of Car2 413 0.56 103.51 94.35 5.00
49 INT82448 Gene_expression of S100a8 246 0.77 236.72 84.02 5.00
50 INT56291 Gene_expression of Ros1 503 0.63 274.12 81.5 5.00
51 INT3214 Localization of Ins1 527 0.80 196.9 79.26 5.00
52 INT12720 Positive_regulation of Il1 246 0.70 195.97 72.05 5.00
53 INT50971 Gene_expression of Ntrk1 180 0.75 73.52 62.28 5.00
54 INT11318 Gene_expression of Gtf3a 274 0.52 183.82 60.89 5.00
55 INT103924 Positive_regulation of Akt1 359 0.69 158.94 60.34 5.00
56 INT79093 Positive_regulation of Nos1 101 0.70 46.89 59.61 5.00
57 INT64159 Gene_expression of Prkca 90 0.78 34.65 55.97 5.00
58 INT3213 Gene_expression of Ins1 511 0.76 357.59 53.32 5.00
59 INT27954 Positive_regulation of Gene_expression of Ngf 87 0.70 57.91 51.96 5.00
60 INT64110 Positive_regulation of Gene_expression of Nos1 68 0.70 58.11 51.64 5.00
61 INT19775 Localization of Il1 183 0.78 145.5 50.91 5.00
62 INT106525 Phosphorylation of Akt1 436 0.82 183.81 47.82 5.00
63 INT29144 Gene_expression of Rvm 41 0.52 29.23 47.76 5.00
64 INT25610 Positive_regulation of Gene_expression of Il1 136 0.67 104.43 43.86 5.00
65 INT52531 Gene_expression of Nfkb1 153 0.75 82.84 42.9 5.00
66 INT57442 Phosphorylation of Prkca 98 0.70 31.58 41.04 5.00
67 INT97596 Localization of S100a8 94 0.78 90.69 40.41 5.00
68 INT20210 Localization of Ngf 69 0.79 46.22 38.57 5.00
69 INT104551 Gene_expression of Il18 156 0.76 115.51 36.95 5.00
70 INT8747 Positive_regulation of Ins1 221 0.69 154.28 35.15 5.00
71 INT14559 Gene_expression of Igf1 254 0.78 112 34.17 5.00
72 INT96913 Positive_regulation of Mapk8 179 0.69 130.44 32.2 5.00
73 INT114881 Gene_expression of Akt1 227 0.78 102.49 31.81 5.00
74 INT124860 Gene_expression of Bace1 330 0.78 157.11 31.65 5.00
75 INT29743 Negative_regulation of App 91 0.59 65.56 31.26 5.00
76 INT64164 Regulation of Prkca 34 0.62 10.44 30.99 5.00
77 INT6660 Positive_regulation of Jun 148 0.69 67.58 29.73 5.00
78 INT47712 Positive_regulation of App 135 0.69 101.38 28.94 5.00
79 INT6364 Gene_expression of Edn1 123 0.78 73.76 28.43 5.00
80 INT133876 Positive_regulation of Gene_expression of Ros1 141 0.32 75.55 27.45 5.00
81 INT37296 Binding of Esr1 117 0.43 62.51 27.33 5.00
82 INT116861 Gene_expression of Apoe 182 0.78 100.41 27.26 5.00
83 INT145426 Positive_regulation of Ros1 185 0.56 106.76 27.21 5.00
84 INT86062 Positive_regulation of Tnfrsf1a 51 0.69 40.69 26.2 5.00
85 INT63769 Regulation of Ngf 44 0.62 21.82 25.84 5.00
86 INT89662 Positive_regulation of Gene_expression of App 169 0.70 133.36 25.62 5.00
87 INT57192 Binding of Ltp 43 0.41 17.48 24.96 5.00
88 INT48240 Binding of Ngf 46 0.46 23.51 24.42 5.00
89 INT49172 Regulation of Nos1 43 0.52 27.53 23.66 5.00
90 INT93738 Gene_expression of Tnfrsf1a 63 0.74 57.66 23.09 5.00
91 INT113925 Localization of Bdnf 59 0.79 24.03 22.76 5.00
92 INT17962 Regulation of Car2 124 0.41 33.98 22.71 5.00
93 INT18322 Negative_regulation of Ins1 132 0.58 88.49 22.59 5.00
94 INT1558 Positive_regulation of Dnahc8 30 0.69 5.78 22.19 5.00
95 INT45437 Localization of Acot1 84 0.79 17.37 22.18 5.00
96 INT139664 Gene_expression of CCL18 83 0.76 37.05 21.95 5.00
97 INT1561 Negative_regulation of Dnahc8 59 0.59 18.12 20.99 5.00
98 INT112029 Positive_regulation of Pik3r1 90 0.67 38.76 20.95 5.00
99 INT11625 Localization of App 98 0.78 55.46 20.86 5.00
100 INT68683 Regulation of Gene_expression of VEGFA 143 0.62 104.19 20.14 5.00
101 INT46016 Gene_expression of Ngfr 69 0.77 41.22 19.8 5.00
102 INT65502 Regulation of App 77 0.62 52.05 19.44 5.00
103 INT17237 Regulation of Esr1 74 0.43 49.09 17.25 5.00
104 INT24225 Gene_expression of Alms1 93 0.62 52.75 16.93 5.00
105 INT8742 Regulation of Localization of Ins1 65 0.61 14.98 16.43 5.00
106 INT112027 Gene_expression of Pik3r1 58 0.75 30.9 15.95 5.00
107 INT16919 Gene_expression of IL36RN 48 0.48 32.78 13.83 5.00
108 INT36177 Binding of Alms1 70 0.31 35.47 13.81 5.00
109 INT14572 Binding of INS 205 0.48 175.43 13.38 5.00
110 INT69569 Positive_regulation of Prnp 175 0.70 96.31 13.34 5.00
111 INT67653 Gene_expression of Om 46 0.36 15.28 13.32 5.00
112 INT114420 Negative_regulation of Pik3r1 67 0.54 34.86 12.82 5.00
113 INT107916 Protein_catabolism of App 114 1.00 66.71 12.38 5.00
114 INT100821 Localization of Ros1 59 0.60 45.26 11.92 5.00
115 INT66038 Positive_regulation of Ngfr 32 0.69 26.07 11.75 5.00
116 INT109315 Gene_expression of Mapk8 70 0.78 45.46 11.65 5.00
117 INT119400 Phosphorylation of Car2 19 0.52 8.47 11.63 5.00
118 INT73431 Positive_regulation of Nos3 82 0.65 53.22 11.61 5.00
119 INT65501 Regulation of Gene_expression of App 56 0.62 32.51 11.48 5.00
120 INT176607 Gene_expression of Cx3cl1 27 0.75 19.51 11.32 5.00
121 INT71363 Binding of Rvm 9 0.31 3.23 10.83 5.00
122 INT4605 Negative_regulation of Gene_expression of INS 220 0.58 139.66 10.75 5.00
123 INT62576 Transcription of Creb1 34 0.69 16.97 10.6 5.00
124 INT25613 Gene_expression of Il1f5 32 0.77 13.29 10.44 5.00
125 INT27955 Negative_regulation of Gene_expression of Ngf 16 0.59 10.43 10.17 5.00
126 INT102865 Positive_regulation of Positive_regulation of Prkca 25 0.69 8.34 9.9 5.00
127 INT6361 Localization of Edn1 30 0.81 19.09 9.7 5.00
128 INT75137 Regulation of Akt1 74 0.48 37.89 9.7 5.00
129 INT46273 Gene_expression of PRNP 103 0.78 110.34 9.25 5.00
130 INT17101 Positive_regulation of Gene_expression of Edn1 24 0.69 24.9 8.86 5.00
131 INT12095 Negative_regulation of Edn1 26 0.59 12.01 8.79 5.00
132 INT104396 Positive_regulation of Positive_regulation of Akt1 44 0.55 14.78 8.69 5.00
133 INT109005 Gene_expression of Proc 61 0.75 37.86 8.49 5.00
134 INT224366 Gene_expression of Ager 111 0.77 125.37 8.49 5.00
135 INT18583 Positive_regulation of Gene_expression of Ins1 67 0.50 49.72 8.26 5.00
136 INT5114 Gene_expression of Ptgis 41 0.50 21.43 8.1 5.00
137 INT67037 Gene_expression of Sod1 121 0.78 59.32 7.99 5.00
138 INT62400 Positive_regulation of Localization of Il1 34 0.67 35.53 7.96 5.00
139 INT22056 Positive_regulation of CYBB 88 0.68 32.13 7.95 5.00
140 INT1150 Gene_expression of ecs 42 0.59 29.38 7.73 5.00
141 INT182750 Gene_expression of Hmgcr 61 0.58 17.23 7.4 5.00
142 INT103925 Negative_regulation of Positive_regulation of Akt1 32 0.58 15.19 7.39 5.00
143 INT55957 Positive_regulation of PRNP 57 0.67 37.87 7.11 5.00
144 INT197493 Localization of Apoe 61 0.79 27.48 7.06 5.00
145 INT5864 Localization of IL36RN 19 0.44 14.5 6.87 5.00
146 INT142344 Transcription of Igf1 22 0.69 7.55 6.77 5.00
147 INT8101 Binding of INCENP 42 0.31 16.2 6.68 5.00
148 INT31598 Gene_expression of Mgst1 41 0.78 6.44 6.3 5.00
149 INT11814 Positive_regulation of Alb 43 0.63 31.71 6.28 5.00
150 INT114882 Positive_regulation of Gene_expression of Akt1 45 0.69 21.29 6.06 5.00
151 INT63042 Binding of Apoe 59 0.48 31.23 5.88 5.00
152 INT146808 Positive_regulation of CCL18 25 0.69 11.98 5.71 5.00
153 INT113700 Positive_regulation of Chuk 30 0.41 21.17 5.69 5.00
154 INT74250 Negative_regulation of Gene_expression of Ins1 47 0.40 39.27 5.37 5.00
155 INT107173 Phosphorylation of App 20 0.82 12.64 5.3 5.00
156 INT3215 Regulation of Gene_expression of Ins1 32 0.52 19.83 4.85 5.00
157 INT102254 Positive_regulation of Gene_expression of Prnp 72 0.70 38.11 4.81 5.00
158 INT137332 Positive_regulation of Gene_expression of Sod1 41 0.70 19.8 4.69 5.00
159 INT116748 Positive_regulation of Gene_expression of Pik3r1 18 0.49 9.83 4.63 5.00
160 INT230810 Phosphorylation of Ins1 59 0.69 41.15 4.51 5.00
161 INT14557 Negative_regulation of Igf1 96 0.59 54.83 4.45 5.00
162 INT93739 Positive_regulation of Gene_expression of Tnfrsf1a 11 0.66 11.17 4.44 5.00
163 INT122569 Negative_regulation of Gene_expression of Akt1 34 0.54 17.15 4.44 5.00
164 INT81750 Regulation of Ntrk1 13 0.52 6.03 4.37 5.00
165 INT116747 Regulation of Pik3r1 18 0.60 9.33 4.34 5.00
166 INT45433 Positive_regulation of Localization of Acot1 18 0.45 1.9 4.32 5.00
167 INT3722 Negative_regulation of Acot1 19 0.42 4.88 4.21 5.00
168 INT230796 Phosphorylation of Irs1 70 0.81 31.73 4.13 5.00
169 INT224369 Binding of Ager 43 0.42 40.57 3.86 5.00
170 INT73602 Positive_regulation of Ager 35 0.69 30.66 3.74 5.00
171 INT131877 Negative_regulation of Nps 12 0.39 8.19 3.56 5.00
172 INT15198 Regulation of Gene_expression of Gtf3a 13 0.10 8.63 3.34 5.00
173 INT118153 Regulation of Positive_regulation of Prkca 5 0.45 3.15 3.23 5.00
174 INT194625 Gene_expression of GSK 18 0.75 9.02 3.23 5.00
175 INT165911 Localization of Pik3r1 15 0.51 7.94 3.2 5.00
176 INT58756 Binding of GPI 10 0.48 7.17 3 5.00
177 INT110755 Negative_regulation of Positive_regulation of Mapk8 15 0.46 9.91 2.98 5.00
178 INT123466 Binding of T2dm2 21 0.37 34.87 2.91 5.00
179 INT184365 Negative_regulation of C3 19 0.43 13.86 2.89 5.00
180 INT198753 Binding of Psd 18 0.20 1.66 2.84 5.00
181 INT39469 Negative_regulation of Alb 21 0.41 13.33 2.68 5.00
182 INT210058 Regulation of ELF3 11 0.29 7.93 2.51 5.00
183 INT16964 Binding of IFNG 27 0.48 14.31 2.45 5.00
184 INT190081 Gene_expression of Abca1 21 0.65 18.18 2.45 5.00
185 INT135040 Regulation of Gene_expression of Prnp 30 0.62 10.52 2.45 5.00
186 INT249378 Negative_regulation of Vamp2 3 0.20 0.27 2.4 5.00
187 INT150476 Positive_regulation of ELF3 32 0.56 13.61 2.39 5.00
188 INT109305 Phosphorylation of Pik3r1 13 0.53 5.69 2.32 5.00
189 INT142265 Regulation of Apoe 20 0.60 9.52 2.23 5.00
190 INT138286 Regulation of Positive_regulation of Akt1 13 0.45 4.93 2.22 5.00
191 INT55291 Gene_expression of Slc2a1 20 0.68 11.46 2.16 5.00
192 INT28739 Binding of Ins1 35 0.37 22.43 2.14 5.00
193 INT114421 Positive_regulation of Positive_regulation of Pik3r1 9 0.49 4.07 2.13 5.00
194 INT172559 Localization of Proc 16 0.02 21.49 2.08 5.00
195 INT201683 Phosphorylation of GSK 15 0.80 6.6 2.01 5.00
196 INT237322 Gene_expression of Irs1 52 0.77 21.07 2 5.00
197 INT8792 Gene_expression of GBA 20 0.78 14.73 1.98 5.00
198 INT15505 Regulation of nt 6 0.24 1.5 1.88 5.00
199 INT123903 Gene_expression of ATXN3 7 0.75 6.71 1.85 5.00
200 INT167203 Binding of PRNP 25 0.48 20.09 1.84 5.00
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