D:Proteus Syndrome

From wiki-pain
Jump to: navigation, search

pChart

Disease Term
Synonyms Elephant Man Disease, PROTEUS LIKE SYNDROME, Syndrome Proteus Like
Documents 12
Hot Single Events 1
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Proteus Syndrome. They are ordered first by their relevance to Proteus Syndrome and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT304029 Binding of PTEN and TP53 1 0.35 0.62 0 5.00
2 INT304020 AR Regulation of TP53 1 0.24 1.11 0 5.00
3 INT304022 Binding of PIK3CG and TP53 1 0.10 0.72 0 5.00
4 INT304028 MDM2 Regulation of TP53 1 0.19 1.11 0 5.00
5 INT304014 Binding of MSI1 and SGCG 1 0.00 1.92 0 5.00
6 INT268345 Binding of TGFB1 and TGFBR2 1 0.27 0.62 0 5.00
7 INT304012 Binding of AKT1 and PIK3CA 1 0.28 1.14 0 5.00
8 INT304018 Regulation of Binding of PIK3CG and TP53 1 0.12 0.73 0 5.00
9 INT268397 Binding of Kras and Regulation of ARAF 1 0.03 1.16 0 5.00
10 INT304025 Binding of PIK3CA and TP53 1 0.30 0.67 0 5.00
11 INT268341 SMAD2 Positive_regulation of SMAD4 1 0.31 0.56 0 5.00
12 INT304015 Binding of PIK3CA and PIK3CG 1 0.09 0.67 0 5.00
13 INT268342 Binding of APC and ANKS1B 1 0.01 0.92 0 5.00
14 INT304019 Binding of AKT1 and TP53 1 0.27 0.72 0 5.00
15 INT304026 Binding of PIK3CG and PTEN 1 0.11 0.62 0 5.00
16 INT268398 Binding of LRP1 and Wnt2 1 0.01 0.36 0 5.00
17 INT268395 Binding of APC and Kras 1 0.04 1.21 0 5.00
18 INT268340 TGFBR2 Positive_regulation of Phosphorylation of TGFB1 1 0.25 0.68 0 5.00
19 INT304027 Negative_regulation of PTEN Positive_regulation of Positive_regulation of AKT1 1 0.32 1.86 0 5.00
20 INT304017 Regulation of Binding of AKT1 and TP53 1 0.32 0.73 0 5.00
21 INT304023 SFRP1 Regulation of Binding of MSI1 1 0.04 1.78 0 5.00
22 INT304016 SFRP4 Regulation of Binding of MSI1 1 0.04 1.78 0 5.00
23 INT268396 Binding of BRAF and Ebp 1 0.01 1.72 0 5.00
24 INT268344 SMAD3 Positive_regulation of SMAD4 1 0.17 0.56 0 5.00
25 INT304013 Binding of SUZ12 and JAZF1 1 0.30 1.89 0 5.00
26 INT304024 Binding of AKT1 and PTEN 1 0.33 1.08 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Proteus Syndrome. They are ordered first by their pain relevance and then by number of times they were reported in Proteus Syndrome. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT119831 Gene_expression of PTEN 55 0.75 40.37 8.57 95.56
2 INT24080 Negative_regulation of Mtor 64 0.37 41.56 5.19 66.40
3 INT53487 Gene_expression of TSC1 81 0.58 77.71 7.94 63.20
4 INT146546 Gene_expression of MSI1 22 0.48 22.91 1.15 61.52
5 INT107987 Gene_expression of MRC1 27 0.75 36.94 1.99 61.12
6 INT196603 Gene_expression of STK11 5 0.55 6.75 0.15 57.76
7 INT12083 Regulation of TGFB1 22 0.53 15.4 3.6 49.84
8 INT268368 Transcription of SMAD4 1 0.54 1.7 0 46.80
9 INT268358 Transcription of BMPR1A 1 0.45 1.7 0 46.80
10 INT190471 Transcription of ENG 3 0.21 1.76 0 46.80
11 INT194993 Binding of RB1 15 0.37 10.96 0.4 43.92
12 INT24020 Positive_regulation of HPS1 6 0.44 6.14 1.08 8.16
13 INT44478 Negative_regulation of PTEN 32 0.57 27.45 0.63 6.72
14 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 5.00
15 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07 5.00
16 INT9196 Gene_expression of PTGS1 215 0.77 96.99 60.5 5.00
17 INT14740 Gene_expression of TGFB1 272 0.78 168.48 60.18 5.00
18 INT10248 Gene_expression of KRT20 436 0.78 231.96 32.88 5.00
19 INT48693 Regulation of VEGFA 268 0.62 191.88 31.52 5.00
20 INT28361 Gene_expression of TP53 443 0.78 384.86 28.8 5.00
21 INT5206 Gene_expression of AR 316 0.78 113.83 27.29 5.00
22 INT9682 Positive_regulation of IGF1 238 0.70 120.03 26.36 5.00
23 INT11159 Gene_expression of EGFR 698 0.78 548.93 25.69 5.00
24 INT9292 Positive_regulation of SGCG 93 0.67 35.13 23.48 5.00
25 INT11157 Binding of EGF 88 0.48 53.73 21.25 5.00
26 INT73593 Gene_expression of BAX 173 0.76 147.81 20.94 5.00
27 INT89396 Phosphorylation of AKT1 225 0.82 111.66 19.61 5.00
28 INT86187 Positive_regulation of AKT1 199 0.69 122.13 19.44 5.00
29 INT12081 Localization of TGFB1 64 0.81 35.4 17.47 5.00
30 INT13510 Gene_expression of ERBB2 530 0.78 405.68 16.79 5.00
31 INT65856 Positive_regulation of TP53 138 0.67 112.65 16.71 5.00
32 INT28950 Positive_regulation of Gene_expression of IGF1 99 0.69 46.9 16.47 5.00
33 INT10214 Gene_expression of VIM 153 0.78 115.88 16.29 5.00
34 INT97245 Gene_expression of AKT1 217 0.77 119.63 15.59 5.00
35 INT20420 Gene_expression of MYC 99 0.75 49.32 14.36 5.00
36 INT94774 Regulation of CDKN2A 43 0.60 44.41 13.99 5.00
37 INT78472 Gene_expression of CDKN2A 223 0.78 173.76 13.61 5.00
38 INT86383 Negative_regulation of EGFR 258 0.59 173.94 13.32 5.00
39 INT27242 Gene_expression of PGR 153 0.75 98.77 12.79 5.00
40 INT25963 Gene_expression of DES 122 0.75 98.81 11.25 5.00
41 INT69264 Gene_expression of KIT 207 0.78 179.41 8.95 5.00
42 INT80420 Gene_expression of IFI27 145 0.78 63.61 8.83 5.00
43 INT57057 Gene_expression of APC 131 0.78 122.24 8.7 5.00
44 INT108202 Positive_regulation of PIK3CG 47 0.67 25.83 8.25 5.00
45 INT60285 Negative_regulation of Racgap1 27 0.56 21.71 8.14 5.00
46 INT111607 Gene_expression of CDH1 103 0.75 90.45 7.77 5.00
47 INT57748 Positive_regulation of Gene_expression of TP53 85 0.69 79.55 7.49 5.00
48 INT16631 Negative_regulation of APC 46 0.57 30.53 7.11 5.00
49 INT38671 Positive_regulation of KRT20 62 0.53 40.17 5.6 5.00
50 INT15376 Positive_regulation of Gene_expression of ERBB2 215 0.70 168.54 5.23 5.00
51 INT89104 Binding of TGFB1 29 0.44 13.67 5.12 5.00
52 INT11158 Positive_regulation of Gene_expression of EGFR 165 0.70 131.26 4.93 5.00
53 INT105336 Regulation of AKT1 52 0.56 32.53 4.89 5.00
54 INT10115 Gene_expression of INSR 31 0.75 11.98 4.86 5.00
55 INT124375 Gene_expression of Wnt2 67 0.56 38.03 4.67 5.00
56 INT62684 Negative_regulation of TP53 66 0.58 66.09 4.62 5.00
57 INT57749 Negative_regulation of Gene_expression of TP53 39 0.56 36.79 4.45 5.00
58 INT89103 Regulation of Gene_expression of TGFB1 15 0.56 8.11 4.37 5.00
59 INT109450 Positive_regulation of Phosphorylation of AKT1 62 0.64 25.18 4.21 5.00
60 INT63121 Binding of APC 29 0.41 23.02 3.8 5.00
61 INT51848 Transcription of TGFB1 17 0.69 9.57 3.53 5.00
62 INT64766 Gene_expression of TWIST1 41 0.76 37.89 3.4 5.00
63 INT52839 Regulation of Racgap1 14 0.25 9.46 3.37 5.00
64 INT51607 Positive_regulation of DES 33 0.67 32.24 3.29 5.00
65 INT94164 Phosphorylation of RB1 83 0.80 48.84 3.21 5.00
66 INT192676 Binding of PTEN 14 0.46 10.58 3.06 5.00
67 INT89392 Negative_regulation of Positive_regulation of AKT1 23 0.50 15.69 3.02 5.00
68 INT200670 Gene_expression of AKT2 25 0.75 16.25 3 5.00
69 INT188047 Positive_regulation of Wnt2 51 0.58 31.41 2.94 5.00
70 INT89397 Positive_regulation of PIK3CA 33 0.67 16.98 2.78 5.00
71 INT95105 Gene_expression of TGFBR2 15 0.64 16.36 2.74 5.00
72 INT74293 Positive_regulation of BAK1 13 0.60 14.13 2.73 5.00
73 INT119838 Positive_regulation of PTEN 25 0.67 21.71 2.5 5.00
74 INT92141 Negative_regulation of CDKN2A 53 0.57 44.23 2.48 5.00
75 INT25208 Gene_expression of IGF2 43 0.74 30.64 2.31 5.00
76 INT179885 Regulation of PTEN 8 0.26 11.88 2.18 5.00
77 INT38674 Regulation of KRT20 32 0.44 19 2.15 5.00
78 INT41775 Gene_expression of NEUROG1 10 0.71 5.46 2.14 5.00
79 INT125080 Positive_regulation of Positive_regulation of TP53 21 0.58 16.16 1.98 5.00
80 INT81641 Gene_expression of Ctnnb1 23 0.72 14.93 1.97 5.00
81 INT20421 Positive_regulation of MYC 19 0.67 10.43 1.9 5.00
82 INT56925 Negative_regulation of TSC1 54 0.52 63.39 1.87 5.00
83 INT48792 Regulation of ERBB2 48 0.57 36.56 1.8 5.00
84 INT86909 Negative_regulation of MSH2 9 0.41 12.65 1.7 5.00
85 INT109975 Positive_regulation of Kras 14 0.45 12.72 1.68 5.00
86 INT268361 Gene_expression of CACNA1G 2 0.46 1.05 1.61 5.00
87 INT180185 Gene_expression of MGMT 22 0.65 15.02 1.57 5.00
88 INT94169 Negative_regulation of Phosphorylation of RB1 16 0.41 8.87 1.57 5.00
89 INT65684 Gene_expression of MDM2 30 0.62 24.94 1.55 5.00
90 INT116836 Binding of FAP 6 0.37 6.76 1.47 5.00
91 INT107985 Gene_expression of MLH1 29 0.67 31.31 1.46 5.00
92 INT162462 Protein_catabolism of TP53 8 0.86 7.89 1.41 5.00
93 INT304045 Transcription of PTEN 2 0.51 4.12 1.4 5.00
94 INT12085 Positive_regulation of Localization of TGFB1 7 0.42 4.9 1.4 5.00
95 INT78470 Negative_regulation of Gene_expression of CDKN2A 14 0.59 14.44 1.38 5.00
96 INT92383 Gene_expression of KRAS 38 0.65 32.94 1.32 5.00
97 INT173892 Phosphorylation of TGFB1 8 0.79 2.63 1.3 5.00
98 INT137382 Negative_regulation of Gene_expression of KRT20 22 0.58 12.29 1.29 5.00
99 INT139237 Negative_regulation of Gene_expression of CDH1 23 0.57 24.31 1.28 5.00
100 INT210399 Gene_expression of IGF2R 22 0.65 17.1 1.23 5.00
101 INT10117 Positive_regulation of INSR 10 0.43 4.71 1.22 5.00
102 INT119832 Positive_regulation of Gene_expression of PTEN 12 0.49 7.12 1.19 5.00
103 INT135556 Localization of AKT1 38 0.69 12.78 1.17 5.00
104 INT220206 Gene_expression of CCNB2 4 0.67 3.75 1.16 5.00
105 INT111605 Positive_regulation of CDH1 12 0.50 7.95 1.15 5.00
106 INT157765 Negative_regulation of CDH1 32 0.53 35.72 1.15 5.00
107 INT86908 Negative_regulation of MLH1 7 0.43 6.98 1.12 5.00
108 INT268379 Gene_expression of ARAF 22 0.16 9.34 1.07 5.00
109 INT92139 Binding of MLH1 12 0.42 15.62 1 5.00
110 INT124374 Binding of Wnt2 21 0.31 10.16 0.99 5.00
111 INT242152 Transcription of Wnt2 8 0.57 5.22 0.88 5.00
112 INT163280 Negative_regulation of Phosphorylation of CCND1 6 0.19 3.92 0.87 5.00
113 INT163289 Phosphorylation of CCND1 7 0.36 4.81 0.81 5.00
114 INT275575 Gene_expression of FOLR1 12 0.66 2.81 0.8 5.00
115 INT161947 Positive_regulation of TGFBR1 2 0.52 1.6 0.76 5.00
116 INT108204 Regulation of PIK3CG 9 0.12 4.16 0.75 5.00
117 INT102813 Regulation of Gene_expression of TP53 25 0.59 25.95 0.75 5.00
118 INT132521 Gene_expression of BRAF 14 0.65 13.59 0.73 5.00
119 INT139205 Binding of NRP1 27 0.45 4.34 0.71 5.00
120 INT86370 Regulation of CDH1 10 0.54 13.89 0.7 5.00
121 INT80674 Negative_regulation of Gene_expression of APC 16 0.59 18.14 0.69 5.00
122 INT206139 Phosphorylation of KRT20 8 0.48 9.1 0.66 5.00
123 INT268377 Phosphorylation of SMAD2 7 0.80 0.85 0.65 5.00
124 INT304060 Positive_regulation of AGR2 2 0.70 13 0.63 5.00
125 INT47038 Gene_expression of SFRP1 14 0.67 9.6 0.63 5.00
126 INT173891 Positive_regulation of Phosphorylation of TGFB1 4 0.49 2 0.59 5.00
127 INT144700 Gene_expression of Kras 21 0.41 12.28 0.57 5.00
128 INT161322 Localization of PTEN 9 0.73 5.65 0.57 5.00
129 INT36619 Gene_expression of SOCS1 9 0.44 4.83 0.55 5.00
130 INT201846 Positive_regulation of SFRP4 4 0.37 2.74 0.54 5.00
131 INT201858 Gene_expression of SFRP4 3 0.48 4.91 0.51 5.00
132 INT81645 Positive_regulation of Gene_expression of Ctnnb1 6 0.63 3.78 0.47 5.00
133 INT47030 Negative_regulation of ARMC9 22 0.38 13.08 0.47 5.00
134 INT201524 Localization of Wnt2 14 0.62 9.24 0.46 5.00
135 INT188050 Regulation of Gene_expression of Wnt2 9 0.37 3.13 0.44 5.00
136 INT148882 Regulation of LTF 9 0.12 4.8 0.44 5.00
137 INT12089 Positive_regulation of MSX2 4 0.46 3.92 0.39 5.00
138 INT81644 Regulation of Ctnnb1 5 0.41 3.38 0.37 5.00
139 INT117564 Gene_expression of SMAD4 12 0.71 8.7 0.37 5.00
140 INT268386 Positive_regulation of ARAF 6 0.17 4.84 0.33 5.00
141 INT185886 Gene_expression of JUP 20 0.75 15.41 0.32 5.00
142 INT107983 Gene_expression of MSH6 6 0.51 5.57 0.27 5.00
143 INT268380 Positive_regulation of Positive_regulation of ARAF 3 0.12 3.49 0.25 5.00
144 INT97473 Positive_regulation of FAP 4 0.34 2.72 0.18 5.00
145 INT181920 Gene_expression of MSH3 2 0.50 2.54 0.18 5.00
146 INT268392 Regulation of Positive_regulation of Wnt2 2 0.09 0.87 0.18 5.00
147 INT268365 Binding of SMAD2 2 0.47 0.56 0.17 5.00
148 INT206869 Gene_expression of ALDH1A2 3 0.38 2.51 0.16 5.00
149 INT206930 Negative_regulation of Gene_expression of MGMT 3 0.40 2.84 0.16 5.00
150 INT292659 Positive_regulation of Gene_expression of FOLR1 2 0.47 1.59 0.14 5.00
151 INT200671 Gene_expression of AKT3 4 0.69 1.88 0.13 5.00
152 INT182621 Localization of MLH1 9 0.64 9.31 0.12 5.00
153 INT182623 Localization of MSH2 3 0.77 5.49 0.12 5.00
154 INT242157 Regulation of Localization of Wnt2 3 0.37 1.08 0.11 5.00
155 INT260148 Negative_regulation of Gene_expression of TGFBR2 3 0.38 3.71 0.1 5.00
156 INT268372 Phosphorylation of APC 3 0.81 3.39 0.09 5.00
157 INT165516 Regulation of MSX2 8 0.23 3.41 0.09 5.00
158 INT184985 Regulation of TFF3 2 0.26 1.43 0.07 5.00
159 INT182302 Negative_regulation of Localization of AKT1 5 0.39 3.52 0.06 5.00
160 INT268387 Gene_expression of RUNX3 2 0.40 3.61 0.06 5.00
161 INT140753 Gene_expression of NTN1 2 0.05 4.67 0.06 5.00
162 INT268389 Positive_regulation of TGFBR2 1 0.39 0.62 0.05 5.00
163 INT206866 Positive_regulation of SFRP1 7 0.51 3.97 0.05 5.00
164 INT170852 Negative_regulation of Gene_expression of IFI27 16 0.55 8.62 0.05 5.00
165 INT244183 Localization of MRC1 2 0.49 3.71 0.05 5.00
166 INT268366 Negative_regulation of Gene_expression of CRABP1 1 0.26 0.84 0.04 5.00
167 INT268364 Gene_expression of CRABP1 1 0.41 0.66 0.04 5.00
168 INT105948 Gene_expression of AURKA 5 0.65 4.26 0.03 5.00
169 INT207233 Transcription of KRAS 3 0.48 1.56 0.03 5.00
170 INT176154 Gene_expression of PIK3CA 6 0.55 10.43 0.03 5.00
171 INT268360 Positive_regulation of SMAD4 3 0.55 1.55 0.03 5.00
172 INT105949 Positive_regulation of Gene_expression of AURKA 3 0.49 1.91 0.03 5.00
173 INT219360 Regulation of MMP11 2 0.54 1.71 0.03 5.00
174 INT172329 Binding of MRC1 8 0.36 3.88 0.03 5.00
175 INT282953 Regulation of MSI1 2 0.03 1.63 0.03 5.00
176 INT268362 Phosphorylation of LRP1 1 0.08 0.35 0 5.00
177 INT268385 Localization of PMS1 1 0.13 2.5 0 5.00
178 INT304047 Positive_regulation of Transcription of TWIST1 1 0.10 0.57 0 5.00
179 INT304067 Positive_regulation of Transcription of GEMIN2 1 0.09 0.57 0 5.00
180 INT268367 Positive_regulation of Regulation of NTN1 1 0.04 1.3 0 5.00
181 INT304078 Regulation of Phosphorylation of KRT20 1 0.00 1 0 5.00
182 INT268375 Positive_regulation of Positive_regulation of MLH1 1 0.12 0.76 0 5.00
183 INT304046 Positive_regulation of Transcription of SNAI2 1 0.49 0.57 0 5.00
184 INT268388 Positive_regulation of Positive_regulation of TGFBR1 1 0.35 0.61 0 5.00
185 INT304062 Regulation of Localization of PTEN 1 0.43 1.29 0 5.00
186 INT304074 Binding of MSH5 1 0.14 1.11 0 5.00
187 INT268384 Positive_regulation of Phosphorylation of SMAD3 1 0.29 1.22 0 5.00
188 INT236621 Regulation of KRAS 7 0.53 6.16 0 5.00
189 INT304066 Gene_expression of BUB1 1 0.07 1.41 0 5.00
190 INT304063 Positive_regulation of ALDH1A2 1 0.29 0.97 0 5.00
191 INT304075 Regulation of AURKA 1 0.15 1.38 0 5.00
192 INT304059 Gene_expression of GEMIN2 1 0.12 0.66 0 5.00
193 INT304058 Positive_regulation of MSI1 1 0.07 2.74 0 5.00
194 INT198037 Regulation of PIK3CA 2 0.28 2.63 0 5.00
195 INT291934 Regulation of FOXA2 2 0.26 2.15 0 5.00
196 INT304050 Gene_expression of SUZ12 1 0.54 6.53 0 5.00
197 INT190053 Gene_expression of CASP5 3 0.45 2.46 0 5.00
198 INT304076 Regulation of Localization of KRAS 2 0.36 2.39 0 5.00
199 INT268371 Positive_regulation of Gene_expression of ARAF 1 0.12 1.4 0 5.00
200 INT268370 Phosphorylation of FAP 1 0.24 1.11 0 5.00
Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox