D:Pruritus

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Disease Term
Synonyms Aquagenic Pruritus, Generalised Pruritus, Generalized Pruritus, Idiopathic Pruritus, Itch, Itching, Localised Pruritus, Localized Pruritus, Prurigo, PRURITIS, PSYCHOGENIC PRURITUS
Documents 3785
Hot Single Events 200
Hot Interactions 30

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Pruritus. They are ordered first by their relevance to Pruritus and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT142371 Trpv1 Positive_regulation of Positive_regulation of Pla2g1b 1 0.35 0.3 0.29 100.00
2 INT16163 Pth Regulation of Gene_expression of Plast4 1 0.00 0.65 0.25 99.80
3 INT163918 Ntp Negative_regulation of Gene_expression of Tacr1 1 0.04 0.74 0.38 99.72
4 INT334530 Sema3a Regulation of Il18 1 0.18 1.61 0.13 99.46
5 INT334524 Sema3a Regulation of Foxq1 1 0.04 1.61 0.13 99.46
6 INT272144 PTAFR Positive_regulation of HRASLS 1 0.08 1.08 0.89 99.12
7 INT159538 SERPINB1 Regulation of Gene_expression of CALCA 1 0.01 0.8 0.45 97.72
8 INT335644 CTSB Positive_regulation of F2RL1 1 0.02 2.58 0.82 97.68
9 INT335643 CTSB Positive_regulation of PAR4 1 0.01 1.3 0.41 97.68
10 INT221847 Binding of Calca and Ntrk1 1 0.03 0.9 0.65 97.48
11 INT119281 Pnoc Regulation of Oprl1 1 0.31 0.29 0.56 97.40
12 INT243276 Hrh4 Positive_regulation of Hrh3 1 0.25 0.78 0.52 97.36
13 INT334532 Sema3a Negative_regulation of Gene_expression of Nrp1 1 0.19 7.58 2 97.28
14 INT334537 Sema3a Negative_regulation of Gene_expression of Plxna1 1 0.08 3.76 1 97.28
15 INT314141 Binding of Tacr3 and SFTPA1 1 0.00 3.02 2.48 96.56
16 INT314136 Binding of TAC1 and SFTPA1 2 0.03 0.78 1.06 96.56
17 INT314142 Binding of TAC1 and Tacr3 1 0.06 0.73 0.94 96.24
18 INT273886 Binding of Dll1 and Trip12 1 0.34 0.1 0 95.00
19 INT306067 Binding of ADH5 and CYLD 1 0.02 3.13 0.19 93.32
20 INT334526 Trpv1 Positive_regulation of Gene_expression of Sema3a 1 0.31 0.92 0.55 92.08
21 INT154538 SF Regulation of Gene_expression of PPY 1 0.11 1 0.14 90.96
22 INT243278 Positive_regulation of Hrh1 Positive_regulation of Pla2g1b 1 0.10 0.3 0.29 90.64
23 INT243274 Positive_regulation of Hrh1 Positive_regulation of Pla2g5 1 0.22 0.3 0.29 90.64
24 INT199593 Binding of TRPV1 and Myoz1 1 0.10 1.7 1.23 89.64
25 INT243273 Hrh1 Positive_regulation of Pla2g1b 1 0.10 0.3 0.29 88.96
26 INT243280 Hrh1 Positive_regulation of Pla2g5 1 0.22 0.3 0.29 88.96
27 INT344709 Niacr1 Positive_regulation of Hdl1 1 0.32 2.74 0.46 87.76
28 INT149940 Smpd1 Positive_regulation of spc 1 0.03 0.19 0.24 86.40
29 INT244396 Binding of Cl and Slc12a2 1 0.03 0.88 0.76 84.72
30 INT278015 Gh Regulation of Ins1 1 0.10 1.47 0.27 81.24
31 INT334522 Ngf Positive_regulation of Nrp1 1 0.19 0.93 0.22 79.12
32 INT334525 Ngf Positive_regulation of Gene_expression of Nrp1 1 0.19 0.93 0.22 79.12
33 INT256418 PPARA Positive_regulation of NR1H4 1 0.01 1.17 0.04 78.48
34 INT278018 Gh Negative_regulation of Phosphorylation of Ins1 1 0.13 1.5 0.29 78.32
35 INT120553 Y-27632 Negative_regulation of Rock1 1 0.01 0.15 0.15 78.24
36 INT120552 Y-27632 Negative_regulation of Rock2 1 0.02 0.15 0.15 78.24
37 INT223482 CRP Positive_regulation of GOPC 1 0.08 0.8 0.1 77.32
38 INT199031 Binding of ALB and F2 1 0.05 1.78 0.08 75.08
39 INT154539 SF Regulation of Protein_catabolism of PPY 1 0.12 0.85 0.11 74.80
40 INT277692 Binding of Atp9a and Tnfrsf10b 1 0.00 1.47 0.1 73.20
41 INT97430 Binding of B2M and HLA-B 1 0.00 0.66 0.04 71.52
42 INT154537 SF Positive_regulation of Gene_expression of PPY 1 0.15 0.81 0.11 71.24
43 INT272412 VSX1 Positive_regulation of Gene_expression of Slc11a1 1 0.00 0.57 0.35 69.52
44 INT272143 PTAFR Positive_regulation of Gene_expression of PTGS2 1 0.12 1.59 0.23 69.36
45 INT278012 Gh Positive_regulation of Gene_expression of Ins1 1 0.11 1.24 0.26 64.72
46 INT278016 Gh Positive_regulation of Localization of Ins1 1 0.16 1.22 0.26 62.24
47 INT304010 Afw1 Negative_regulation of Gene_expression of ISYNA1 1 0.00 0.27 0.1 62.16
48 INT280007 Binding of CLTC and PAEP 1 0.06 0.8 0.08 61.36
49 INT218510 Binding of C3 and Cfb 1 0.02 0.53 0.2 59.36
50 INT262752 IGHA1 Positive_regulation of IGKV2D-19 1 0.00 1.39 0 57.40
51 INT329797 Positive_regulation of TLR2 Positive_regulation of Gene_expression of IL6 1 0.02 1.67 0.11 56.68
52 INT329802 Positive_regulation of TLR2 Regulation of Gene_expression of IL6 1 0.01 1.67 0.11 56.68
53 INT327940 Crh Positive_regulation of Gene_expression of F2rl1 1 0.44 5.57 2.5 55.40
54 INT131162 Binding of CD58 and Cd2 1 0.01 1.21 0.18 53.92
55 INT131163 Negative_regulation of Binding of CD58 and Cd2 1 0.01 0.6 0.09 53.92
56 INT280004 Binding of IFNA1 and CDIPT 1 0.01 0.74 0.08 52.72
57 INT280005 Binding of PAEP and CDIPT 1 0.01 0.74 0.08 52.40
58 INT262558 Phax Positive_regulation of Trpv1 1 0.01 1.26 1.92 51.04
59 INT288326 Sds Positive_regulation of Glyr1 1 0.10 0.12 0.68 50.56
60 INT288324 Sds Positive_regulation of Gene_expression of Glyr1 1 0.10 0.12 0.68 50.56
61 INT351032 Binding of CD80 and CD96 1 0.01 0.36 0.09 47.44
62 INT351031 Binding of CD28 and CD96 1 0.02 0.36 0.09 47.44
63 INT149117 Binding of CD80 and CTLA4 31 0.52 12.7 7.73 46.48
64 INT186126 Binding of CD28 and CTLA4 9 0.52 4.13 3.12 46.48
65 INT194647 Binding of CD28 and CD80 15 0.40 4.9 3.22 46.20
66 INT306745 Binding of Il12a and IL23A 1 0.10 3.25 1.56 44.76
67 INT193215 Binding of CYSLTR1 and CYSLTR2 2 0.09 1.7 0.21 42.96
68 INT334529 Pax3 Positive_regulation of Gene_expression of Ngf 1 0.03 0.31 0.91 42.48
69 INT347516 Binding of CYSLTR2 and Ltc4s 1 0.01 0.4 0.03 42.24
70 INT347514 Binding of CYSLTR1 and Ltc4s 1 0.01 0.58 0.03 36.64
71 INT226527 Il1rl1 Positive_regulation of Gene_expression of IK 1 0.00 0.42 0.15 34.48
72 INT334531 Nrp1 Negative_regulation of Gene_expression of Il4 1 0.08 0.48 0.14 32.64
73 INT334527 Sema3a Negative_regulation of Gene_expression of Il4 1 0.15 0.48 0.14 32.64
74 INT334534 Nrp1 Negative_regulation of Gene_expression of Sema3a 1 0.17 0.48 0.14 32.64
75 INT334528 Nrp1 Negative_regulation of Sema3a 1 0.17 0.47 0.13 27.96
76 INT38711 CYSLTR1 Positive_regulation of Gene_expression of PTGS1 1 0.08 0.14 0.25 25.00
77 INT106487 Gene_expression of CD177 Negative_regulation of Gene_expression of Mpl 1 0.02 1.74 0.04 25.00
78 INT106486 Gene_expression of CD177 Negative_regulation of Gene_expression of Bcl2l1 1 0.01 1.87 0.04 25.00
79 INT334538 Il18 Positive_regulation of Localization of IFN1@ 1 0.34 0.65 0 25.00
80 INT175329 Binding of ICAM1 and ITGAL 14 0.18 10.06 2.81 22.08
81 INT186123 Binding of GIF and IL10 1 0.23 1.17 0.69 13.32
82 INT351281 AP1M2 Regulation of NCOR2 1 0.00 0.85 1.9 12.84
83 INT277765 Binding of BCR and Abl1 1 0.18 1.55 0.03 5.68
84 INT176477 Binding of CXCR3 and CXCL10 14 0.25 10.61 5.87 5.00
85 INT101942 Binding of CD40 and CD40LG 16 0.23 15.24 4.01 5.00
86 INT127128 Binding of CNR1 and CNR2 8 0.39 3.98 3.97 5.00
87 INT69032 IL18 Positive_regulation of IFNA1 12 0.23 7.87 3.83 5.00
88 INT186128 Binding of CD2 and CD58 8 0.10 7.59 2.76 5.00
89 INT115367 Binding of IL6 and IL6R 12 0.07 8.16 2.36 5.00
90 INT279361 Binding of TNF and KLF1 4 0.00 3.72 2.19 5.00
91 INT279359 Binding of ADA and TNF 1 0.20 2.61 1.91 5.00
92 INT93293 Ngf Regulation of Trpv1 2 0.28 0.71 1.9 5.00
93 INT334343 GRP Regulation of Binding of GRP and Helt 1 0.02 0 1.81 5.00
94 INT334345 Binding of GRP and Helt 1 0.02 0 1.79 5.00
95 INT334347 GRP Positive_regulation of Localization of Gabrg1 1 0.19 0 1.5 5.00
96 INT121226 Ngf Regulation of Gene_expression of Trpv1 2 0.62 0.7 1.44 5.00
97 INT262568 Prkaca Regulation of Trpv1 2 0.10 0.65 1.38 5.00
98 INT247924 Slc12a5 Regulation of Gene_expression of Slc12a2 1 0.25 1.43 1.23 5.00
99 INT247926 Slc12a5 Regulation of Cl 1 0.01 1.43 1.23 5.00
100 INT247925 Slc12a2 Regulation of Cl 1 0.01 1.44 1.23 5.00
101 INT197092 TNF Regulation of VEGFA 4 0.21 2.78 1.22 5.00
102 INT71176 Binding of ICAM1 and ITGB2 4 0.21 4.93 1.07 5.00
103 INT186125 Negative_regulation of Binding of CD2 and CD58 3 0.12 3.04 1.06 5.00
104 INT291377 Binding of CX3CR1 and Cx3cl1 2 0.36 3.57 1.02 5.00
105 INT206074 Binding of IL6 and IL6ST 7 0.32 3.79 1.01 5.00
106 INT341479 Binding of SCN2A and SCN4A 1 0.37 1.29 0.98 5.00
107 INT341480 Binding of SCN1A and SCN4A 1 0.36 1.29 0.98 5.00
108 INT115656 Glp1r Positive_regulation of Localization of Ins1 2 0.42 5.23 0.91 5.00
109 INT126268 Tpsab1 Positive_regulation of F2rl1 2 0.35 1.65 0.88 5.00
110 INT134454 EGF Positive_regulation of EGFR 3 0.56 1.32 0.88 5.00
111 INT326455 Runx1 Positive_regulation of Gene_expression of Trpv1 1 0.45 0 0.88 5.00
112 INT90387 ROS1 Positive_regulation of NFKB1 4 0.32 2.35 0.87 5.00
113 INT298295 Runx1 Negative_regulation of Gene_expression of Ntrk1 2 0.38 0.45 0.86 5.00
114 INT226337 Binding of IL10 and IL10RA 2 0.24 2.51 0.85 5.00
115 INT226340 Binding of CD4 and IFNA1 3 0.03 3.84 0.85 5.00
116 INT262572 Ngf Positive_regulation of Mapk1 2 0.04 0.52 0.81 5.00
117 INT262564 Ngf Positive_regulation of Pik3r1 1 0.08 0.36 0.8 5.00
118 INT262579 Ngf Positive_regulation of Prkca 1 0.07 0.36 0.8 5.00
119 INT226371 IL18 Positive_regulation of IL4 4 0.05 2.49 0.79 5.00
120 INT262582 F2rl1 Regulation of Positive_regulation of Prkca 1 0.03 0.58 0.78 5.00
121 INT262562 F2rl1 Regulation of Trpv1 1 0.12 0.58 0.77 5.00
122 INT262563 Negative_regulation of Pax3 Regulation of Calca 1 0.01 0.75 0.76 5.00
123 INT262569 Pax3 Regulation of Calca 1 0.00 0.75 0.76 5.00
124 INT262577 Localization of Ngf Positive_regulation of Positive_regulation of Mapk14 1 0.05 0.92 0.75 5.00
125 INT262578 Prkaca Positive_regulation of Localization of Calca 1 0.03 0.71 0.75 5.00
126 INT111080 Binding of CA1 and CA2 2 0.02 1.62 0.73 5.00
127 INT213026 Hdl1 Positive_regulation of Nos3 5 0.16 7.92 0.73 5.00
128 INT288323 Glyr1 Regulation of Sds 1 0.05 0.2 0.72 5.00
129 INT262573 Par2 Regulation of Positive_regulation of Prkca 1 0.05 0.57 0.72 5.00
130 INT334348 GRP Regulation of Helt 1 0.01 0 0.72 5.00
131 INT262580 Ngf Positive_regulation of Hspg2 1 0.03 0.35 0.72 5.00
132 INT11684 Binding of CSF2 and IL3 6 0.36 3.3 0.72 5.00
133 INT272147 PTAFR Positive_regulation of CA2 1 0.13 0 0.71 5.00
134 INT326457 Runx1 Regulation of Mrgpra3 1 0.37 0.1 0.71 5.00
135 INT262581 Prkca Positive_regulation of Phosphorylation of Trpv1 1 0.13 0.28 0.71 5.00
136 INT326456 Runx1 Regulation of Pip4k2b 1 0.09 0.11 0.71 5.00
137 INT226540 Binding of IL24 and Il20ra 1 0.00 0.97 0.71 5.00
138 INT262574 Gnaq Positive_regulation of Prkca 1 0.00 0.57 0.71 5.00
139 INT262566 Par2 Regulation of Trpv1 1 0.20 0.57 0.71 5.00
140 INT262571 Phosphorylation of Trpv1 Positive_regulation of Localization of Calca 1 0.17 0.71 0.7 5.00
141 INT209593 Negative_regulation of Adcy1 Negative_regulation of Positive_regulation of Ltp 1 0.10 0 0.69 5.00
142 INT262570 Binding of Pax3 and Trpv1 1 0.02 1.05 0.67 5.00
143 INT262576 Binding of Calca and Trpv1 1 0.13 1.05 0.66 5.00
144 INT252869 Binding of Trpv1 and Phax 2 0.01 0.18 0.6 5.00
145 INT274167 Il13 Regulation of Il5 2 0.09 2.05 0.59 5.00
146 INT272146 PTAFR Positive_regulation of Localization of IL8 3 0.38 0.28 0.59 5.00
147 INT280895 Runx1 Positive_regulation of Gene_expression of Ret 2 0.33 0.2 0.58 5.00
148 INT334500 Binding of IGHE and SPARCL1 1 0.01 1.47 0.55 5.00
149 INT334346 GRP Regulation of Gene_expression of Helt 1 0.03 0 0.55 5.00
150 INT209591 Car2 Positive_regulation of Positive_regulation of Ltp 1 0.05 0 0.54 5.00
151 INT226360 IL18 Positive_regulation of Gene_expression of IL4 1 0.05 2.66 0.54 5.00
152 INT209592 Car2 Positive_regulation of Localization of Ltp 1 0.05 0 0.54 5.00
153 INT226348 IL18 Positive_regulation of Gene_expression of IL13 1 0.03 2.66 0.54 5.00
154 INT226517 Binding of IL19 and Il20ra 1 0.00 0.69 0.53 5.00
155 INT274170 Il13 Regulation of Il4 3 0.09 2.75 0.51 5.00
156 INT208121 Binding of Grin2a and Grin2b 3 0.35 0.06 0.51 5.00
157 INT262565 Prkaca Regulation of Negative_regulation of Trpv1 1 0.05 0.21 0.5 5.00
158 INT206010 Foxm1 Positive_regulation of Gene_expression of Il18 1 0.03 0.72 0.5 5.00
159 INT313635 MUC7 Negative_regulation of Rbm39 1 0.00 0 0.48 5.00
160 INT260858 IL6 Positive_regulation of Gene_expression of VEGFA 2 0.31 1.77 0.48 5.00
161 INT306732 Il17a Positive_regulation of Gene_expression of Il2 1 0.09 1.07 0.46 5.00
162 INT306731 Il22 Positive_regulation of Gene_expression of Il2 1 0.12 1.07 0.46 5.00
163 INT329794 TLR2 Positive_regulation of Positive_regulation of IL12A 1 0.01 1.05 0.44 5.00
164 INT262575 Trpv1 Positive_regulation of Prkca 1 0.13 0.17 0.44 5.00
165 INT279360 ADA Negative_regulation of Gene_expression of IFNG 1 0.06 0.51 0.44 5.00
166 INT226341 S1PR1 Regulation of MBTPS1 1 0.00 0.76 0.44 5.00
167 INT311587 CXCL10 Regulation of Gene_expression of VEGFA 1 0.23 0.45 0.43 5.00
168 INT311590 EGF Regulation of Gene_expression of CXCL10 1 0.23 0.51 0.43 5.00
169 INT326458 Runx1 Negative_regulation of Gene_expression of Calca 1 0.18 0.05 0.43 5.00
170 INT311589 EGF Regulation of Gene_expression of VEGFA 1 0.18 0.51 0.43 5.00
171 INT311591 CXCL10 Regulation of Gene_expression of EGF 1 0.23 0.51 0.43 5.00
172 INT329803 TLR2 Positive_regulation of Positive_regulation of IL6 1 0.01 0.94 0.41 5.00
173 INT329800 TLR2 Positive_regulation of Positive_regulation of IL8 1 0.01 0.99 0.41 5.00
174 INT329801 Binding of CAMP and IFNA1 1 0.03 1.48 0.4 5.00
175 INT351237 HRAS Regulation of CBL 1 0.00 0.48 0.4 5.00
176 INT260744 Binding of Ecm1 and Tlr2 1 0.00 0.45 0.39 5.00
177 INT329799 Binding of CD14 and LY96 2 0.04 1.02 0.39 5.00
178 INT226381 S1PR1 Positive_regulation of Gene_expression of IK 1 0.00 0.64 0.38 5.00
179 INT260746 Binding of TLR4 and Ecm1 1 0.02 0.44 0.38 5.00
180 INT260747 Binding of TLR4 and Tlr2 1 0.05 0.44 0.38 5.00
181 INT334533 Binding of Foxq1 and Ngf 1 0.05 0.8 0.38 5.00
182 INT272148 PTAFR Regulation of Localization of CA2 1 0.14 0 0.38 5.00
183 INT230584 Positive_regulation of Trpv1 Positive_regulation of Trpm8 1 0.28 0.16 0.37 5.00
184 INT226350 MBTPS1 Negative_regulation of Gene_expression of CD4 1 0.03 0.61 0.37 5.00
185 INT262760 Binding of TEP1 and CD163L1 1 0.00 1.65 0.37 5.00
186 INT226374 Negative_regulation of Binding of CD4 and IFNA1 1 0.03 0.66 0.37 5.00
187 INT245328 Binding of Esr2 and Pgr 1 0.03 0.41 0.37 5.00
188 INT230585 Trpv1 Positive_regulation of Trpm8 1 0.28 0.15 0.36 5.00
189 INT279369 Binding of ADA and Ifx 1 0.29 0.27 0.35 5.00
190 INT310934 Positive_regulation of Tgm2 Positive_regulation of Binding of IGHE 1 0.14 1.33 0.34 5.00
191 INT353010 Binding of GJA8 and TNF 1 0.02 0.24 0.33 5.00
192 INT347517 Binding of Tbxa2r and ST7L 1 0.00 0 0.32 5.00
193 INT186127 CTLA4 Negative_regulation of CD28 1 0.19 0.74 0.32 5.00
194 INT288325 Binding of Glyr1 and Sds 1 0.07 0 0.3 5.00
195 INT187361 Binding of Gabrg1 and Kcnn3 1 0.36 0.13 0.3 5.00
196 INT334499 Binding of AMELX and IL4 1 0.12 0.47 0.29 5.00
197 INT226512 Il1rl1 Positive_regulation of Jun 1 0.12 0.34 0.29 5.00
198 INT226375 INCENP Positive_regulation of Regulation of TH1L 1 0.01 0.57 0.29 5.00
199 INT353009 Binding of GJA8 and VSIG1 1 0.00 0 0.29 5.00
200 INT226376 INCENP Negative_regulation of Gene_expression of TH1L 1 0.00 0.61 0.29 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Pruritus. They are ordered first by their pain relevance and then by number of times they were reported in Pruritus. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT6625 Negative_regulation of Pth 96 0.58 57.6 8.24 100.00
2 INT164987 Gene_expression of Mrgprx1 5 0.64 4.26 3.47 100.00
3 INT95650 Negative_regulation of Positive_regulation of Ngf 6 0.43 4.41 1.84 100.00
4 INT77902 Negative_regulation of Positive_regulation of TRPV1 30 0.59 9.36 19.2 100.00
5 INT182667 Binding of DLAT 11 0.31 40.75 2.8 99.98
6 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 99.96
7 INT18930 Positive_regulation of Hrh1 20 0.63 7.77 12.96 99.96
8 INT9954 Negative_regulation of Hrh1 16 0.52 13.04 11.76 99.96
9 INT8357 Gene_expression of KNG1 153 0.75 77.26 68.66 99.96
10 INT158 Localization of Prl 2431 0.81 378.96 952.2 99.96
11 INT20899 Negative_regulation of GNAI1 12 0.57 4.24 6.07 99.96
12 INT87687 Positive_regulation of Trpv1 409 0.70 210.24 257.59 99.92
13 INT703 Positive_regulation of Pth 177 0.70 127.09 27.26 99.92
14 INT74365 Positive_regulation of Alox5 19 0.47 11.03 4.04 99.92
15 INT25990 Positive_regulation of Pla2g5 11 0.69 4.93 3.32 99.92
16 INT102731 Regulation of ABCB1 29 0.62 5.36 11.67 99.88
17 INT91703 Negative_regulation of Myoz1 78 0.58 53.78 13.5 99.84
18 INT100733 Positive_regulation of F2RL1 62 0.70 59.14 35.22 99.84
19 INT4985 Positive_regulation of Tac1 81 0.69 35.79 50.67 99.84
20 INT3597 Positive_regulation of Pla2g1b 37 0.63 17.94 11.41 99.82
21 INT6624 Gene_expression of Pth 135 0.76 110.27 27.54 99.80
22 INT138018 Gene_expression of Il31 3 0.46 5.46 1.82 99.80
23 INT11804 Positive_regulation of Gene_expression of Il2 70 0.70 33 21.63 99.80
24 INT41855 Localization of Grp 6 0.71 1.13 1.36 99.80
25 INT16161 Gene_expression of Plast4 1 0.00 0.64 0.25 99.80
26 INT24326 Gene_expression of Ngf 346 0.78 218.67 184.71 99.76
27 INT12095 Negative_regulation of Edn1 26 0.59 12.01 8.79 99.76
28 INT14884 Positive_regulation of Gene_expression of SFTPA1 32 0.25 20.37 26.09 99.70
29 INT9489 Gene_expression of SFTPA1 112 0.66 55.38 66.45 99.70
30 INT8835 Localization of SFTPA1 65 0.68 32.81 38.65 99.70
31 INT104674 Positive_regulation of F2rl1 35 0.65 27.76 14.16 99.68
32 INT8836 Positive_regulation of SFTPA1 36 0.47 28.37 23.59 99.68
33 INT69749 Binding of Tacr3 3 0.06 2.2 0.81 99.68
34 INT48877 Binding of Tacr1 16 0.43 5.26 8.04 99.68
35 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 99.64
36 INT22112 Positive_regulation of Localization of TNF 164 0.70 115.66 52.18 99.64
37 INT397 Localization of SST 232 0.81 58.05 101.19 99.62
38 INT5117 Negative_regulation of Gene_expression of IL2 118 0.59 52.33 29.96 99.60
39 INT11807 Gene_expression of Il2 266 0.78 112 64.97 99.60
40 INT15213 Positive_regulation of Htas2 9 0.67 3.86 5.14 99.58
41 INT4759 Negative_regulation of Localization of Calca 294 0.59 82.62 226.45 99.58
42 INT167882 Negative_regulation of Il31 1 0.07 1.35 0.34 99.56
43 INT15148 Gene_expression of Vip 51 0.77 25.61 18.33 99.48
44 INT5010 Gene_expression of Calca 197 0.78 85.76 118.75 99.48
45 INT14624 Gene_expression of Pax3 100 0.38 33.22 69.47 99.48
46 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 99.48
47 INT26217 Binding of Calca 22 0.48 5.22 12.57 99.48
48 INT28265 Positive_regulation of Calca 62 0.70 29.1 41.17 99.48
49 INT54987 Regulation of Gene_expression of Calca 6 0.62 3.44 4.59 99.48
50 INT15146 Regulation of Gene_expression of Vip 3 0.53 0.89 2.23 99.48
51 INT720 Positive_regulation of POMC 807 0.70 237.37 353.83 99.46
52 INT8905 Gene_expression of EDN1 215 0.78 157.1 34.19 99.44
53 INT5540 Positive_regulation of Oprm1 344 0.70 76.77 319.71 99.40
54 INT9852 Positive_regulation of Gpt 563 0.70 364.64 146.82 99.36
55 INT724 Negative_regulation of Alb 151 0.59 93.57 29.65 99.36
56 INT69820 Binding of Hrh3 6 0.37 0.89 1.58 99.36
57 INT243270 Binding of Grpr 1 0.09 0.83 0.77 99.34
58 INT18357 Gene_expression of TRPV1 825 0.78 307.11 382.81 99.32
59 INT2542 Localization of Calca 2008 0.81 518.3 1408.65 99.30
60 INT3375 Gene_expression of IGHE 535 0.77 387.47 65.46 99.28
61 INT5979 Gene_expression of Oprd1 428 0.78 75.64 320.32 99.28
62 INT221844 Regulation of Binding of Il31 1 0.12 2.18 0.97 99.28
63 INT10668 Positive_regulation of Gene_expression of Oprd1 61 0.69 15.21 52.12 99.28
64 INT3988 Positive_regulation of Gene_expression of IGHE 98 0.68 91.46 9.61 99.28
65 INT8629 Positive_regulation of COL7A1 72 0.69 40.66 12.09 99.28
66 INT167883 Negative_regulation of Hrh4 1 0.03 1.35 0.34 99.26
67 INT145494 Positive_regulation of Grpr 2 0.50 2.25 1.26 99.24
68 INT120562 Negative_regulation of Egfr 108 0.59 79.38 3.11 99.24
69 INT35366 Binding of AR 87 0.47 30.52 8.9 99.24
70 INT75742 Binding of RLS 86 0.42 95.27 19.04 99.20
71 INT92934 Gene_expression of GRPR 2 0.67 5.13 1.57 99.16
72 INT23178 Gene_expression of H1 38 0.68 13.37 9.09 99.16
73 INT4148 Gene_expression of HRH1 11 0.77 2.71 4.22 99.16
74 INT6042 Binding of Oprm1 248 0.48 31.77 154.34 99.16
75 INT3167 Binding of KNG1 48 0.48 23.26 26.77 99.12
76 INT8388 Positive_regulation of Vip 142 0.70 39.72 67.61 99.10
77 INT14497 Gene_expression of GRP 82 0.78 17.67 32.27 99.04
78 INT221846 Localization of NTF4 3 0.37 1.24 1.24 99.00
79 INT108932 Gene_expression of NTF4 4 0.40 1.65 1.58 99.00
80 INT117601 Positive_regulation of Trpa1 174 0.70 72.41 71.9 98.92
81 INT245536 Regulation of Gene_expression of Runx1 11 0.58 6.22 4.88 98.92
82 INT19771 Positive_regulation of PAG1 69 0.61 75.61 76.88 98.88
83 INT221845 Gene_expression of Klk7 2 0.04 1.71 0.82 98.88
84 INT221843 Positive_regulation of Gene_expression of Klk7 1 0.01 1.53 0.63 98.88
85 INT76660 Gene_expression of Trpv1 691 0.78 329.46 386.42 98.84
86 INT8640 Positive_regulation of HSD11B1 332 0.67 377.84 22.36 98.84
87 INT4421 Positive_regulation of LAP 12 0.44 11.06 1.74 98.84
88 INT27585 Positive_regulation of smc 9 0.58 3.2 1.47 98.84
89 INT27587 Positive_regulation of STAR 7 0.46 6.37 0.99 98.84
90 INT73731 Binding of RAPH1 9 0.33 14.58 0.5 98.84
91 INT154869 Gene_expression of Hrh4 2 0.26 1.33 0.38 98.82
92 INT111016 Gene_expression of F2rl1 11 0.73 3.58 2.37 98.82
93 INT4585 Gene_expression of Serping1 19 0.46 12.4 2.35 98.82
94 INT243271 Positive_regulation of Hrh4 4 0.52 3.46 2.31 98.80
95 INT2391 Negative_regulation of PTGS1 501 0.59 207.62 205.6 98.74
96 INT64440 Gene_expression of Pnoc 66 0.78 13.61 41.76 98.68
97 INT1319 Gene_expression of Oprl1 65 0.78 9.34 42.41 98.68
98 INT49319 Regulation of Hrh2 5 0.45 2.31 5.04 98.68
99 INT5660 Binding of Oprd1 477 0.48 71.86 342.06 98.66
100 INT188844 Gene_expression of AES 44 0.58 33.94 5.85 98.64
101 INT51841 Positive_regulation of CHPT1 13 0.43 6.82 3.62 98.64
102 INT133211 Gene_expression of Runx1 169 0.77 83.4 76.16 98.60
103 INT4893 Gene_expression of Tacr1 366 0.78 129.67 213.92 98.58
104 INT6852 Localization of TNF 883 0.81 705.95 270.84 98.58
105 INT63769 Regulation of Ngf 44 0.62 21.82 25.84 98.58
106 INT50971 Gene_expression of Ntrk1 180 0.75 73.52 62.28 98.56
107 INT615 Regulation of Alb 66 0.62 33.43 15.33 98.50
108 INT21793 Positive_regulation of Ngf 154 0.70 94.78 85.27 98.48
109 INT3987 Positive_regulation of IGHE 316 0.70 283.2 40.16 98.48
110 INT152550 Regulation of Hrh3 2 0.45 1.17 0.75 98.48
111 INT25503 Gene_expression of C5AR1 22 0.75 21.88 4.16 98.46
112 INT335648 Localization of CTSS 1 0.08 1.39 0.41 98.44
113 INT50105 Localization of CTSB 29 0.78 10.98 5.21 98.44
114 INT93059 Positive_regulation of Siglece 3 0.38 5.96 2.49 98.40
115 INT1125 Positive_regulation of IGHG3 130 0.69 112.07 13.18 98.36
116 INT37193 Negative_regulation of BDNF-AS 21 0.37 15.06 3.12 98.30
117 INT2604 Positive_regulation of Got1 223 0.70 154.78 49.51 98.28
118 INT59175 Localization of TNMD 4 0.70 4.14 0.71 98.28
119 INT613 Gene_expression of Alb 268 0.78 149.84 42.78 98.24
120 INT70049 Positive_regulation of Gene_expression of LTA 7 0.32 4.66 3.25 98.24
121 INT116728 Negative_regulation of ARSH 9 0.13 9.67 0.27 98.24
122 INT4937 Negative_regulation of Oprd1 224 0.59 44.51 171.11 98.20
123 INT147606 Positive_regulation of TLR1 5 0.67 4.35 0.47 98.08
124 INT124954 Gene_expression of Egfr 26 0.75 15.08 3.12 98.00
125 INT233113 Regulation of Trpm8 24 0.61 18.08 13.17 97.96
126 INT94410 Gene_expression of Grp 4 0.67 2.49 1.97 97.92
127 INT4053 Regulation of GRP 27 0.58 5.57 13.76 97.88
128 INT13539 Gene_expression of LTA 39 0.62 22.55 8.07 97.88
129 INT29105 Positive_regulation of OPRK1 68 0.70 7.06 44.69 97.80
130 INT51154 Gene_expression of Grpr 10 0.69 1.77 3.12 97.80
131 INT53142 Negative_regulation of Gene_expression of Tac1 7 0.56 1.59 3.61 97.76
132 INT4283 Positive_regulation of Cbs 10 0.46 6.85 4.44 97.76
133 INT9381 Positive_regulation of TRPV1 523 0.70 187.4 276.05 97.72
134 INT12602 Negative_regulation of Oprm1 190 0.59 36.11 177.85 97.72
135 INT48006 Negative_regulation of Oprk1 27 0.58 10.14 19.11 97.72
136 INT69569 Positive_regulation of Prnp 175 0.70 96.31 13.34 97.60
137 INT69572 Localization of Prnp 96 0.81 38.11 5.45 97.60
138 INT18843 Binding of H1 10 0.47 5.44 2.4 97.60
139 INT13752 Binding of Scn4a 24 0.36 5.68 14.16 97.52
140 INT22943 Positive_regulation of Positive_regulation of Gpt 23 0.47 16.09 5.55 97.52
141 INT108384 Binding of Ntrk1 28 0.39 10.73 9.09 97.48
142 INT505 Positive_regulation of GPT 89 0.67 69.38 14.94 97.48
143 INT25991 Negative_regulation of Vip 11 0.53 6.76 4.64 97.44
144 INT88867 Localization of MCS 19 0.62 28.31 3.88 97.40
145 INT77430 Negative_regulation of HTs 1 0.57 0.87 0.4 97.36
146 INT755 Regulation of HRH2 7 0.45 2.87 2.68 97.36
147 INT47459 Gene_expression of Rac1 101 0.68 45.27 24.33 97.36
148 INT20210 Localization of Ngf 69 0.79 46.22 38.57 97.32
149 INT65125 Gene_expression of Tacr1 81 0.77 23.9 38.35 97.28
150 INT15202 Regulation of Tacr1 26 0.60 9.65 16.48 97.28
151 INT1169 Negative_regulation of Bche 322 0.59 149.22 61.27 97.28
152 INT117600 Positive_regulation of Trpm8 65 0.70 31.96 24.46 97.20
153 INT115108 Negative_regulation of Gene_expression of FAS 9 0.57 9.16 1.23 97.20
154 INT25353 Negative_regulation of F8 22 0.59 18.51 1.4 97.20
155 INT58061 Gene_expression of Trpv1 1117 0.78 451.54 637.59 97.16
156 INT10506 Gene_expression of PTAFR 86 0.76 37.57 28.58 97.16
157 INT4806 Localization of TPSAB1 29 0.80 5.05 10.52 97.16
158 INT4805 Positive_regulation of Localization of TPSAB1 9 0.55 0.32 5.38 97.16
159 INT106548 Localization of Adcyap1 14 0.80 5.05 4.33 97.12
160 INT65965 Gene_expression of Adcyap1 52 0.78 22.53 13.14 97.12
161 INT7344 Gene_expression of TAC1 132 0.75 35.48 68.26 97.08
162 INT335647 Gene_expression of OSMR 1 0.48 2.78 0.72 97.04
163 INT3824 Negative_regulation of PTH 40 0.59 28.58 3.39 97.00
164 INT153189 Gene_expression of Sema3a 19 0.75 14.37 4.21 96.96
165 INT4742 Gene_expression of Tac1 177 0.78 69.99 102.66 96.96
166 INT40084 Binding of HBS1L 8 0.36 9.15 0.69 96.96
167 INT169194 Negative_regulation of CASP7 3 0.26 2.23 0.26 96.88
168 INT1020 Negative_regulation of BCHE 109 0.59 44.86 16.4 96.88
169 INT6584 Negative_regulation of Pax3 31 0.39 14.64 27.97 96.80
170 INT15229 Positive_regulation of CNDP1 21 0.69 15.86 4.06 96.76
171 INT621 Positive_regulation of SERPINH1 19 0.57 21.52 8.44 96.72
172 INT5398 Positive_regulation of ALPP 178 0.70 110.52 19.18 96.68
173 INT23676 Gene_expression of Chrna7 47 0.75 23.66 9.51 96.68
174 INT91891 Gene_expression of Kit 268 0.78 158.89 22.67 96.68
175 INT5201 Negative_regulation of Gene_expression of Fosl1 8 0.54 1.63 5.06 96.60
176 INT60423 Positive_regulation of TPSG1 11 0.57 11.02 2.55 96.58
177 INT49219 Gene_expression of Hrh1 28 0.75 13.77 14.99 96.48
178 INT122399 Binding of Hrh2 3 0.38 1.27 1.64 96.48
179 INT92935 Binding of GRPR 2 0.32 1.99 0.62 96.44
180 INT5200 Gene_expression of Fos 3083 0.78 894.43 1639.02 96.44
181 INT5591 Regulation of Gene_expression of Fos 425 0.62 129.06 265.78 96.44
182 INT221842 Binding of Il31 1 0.10 2.09 0.94 96.40
183 INT34869 Negative_regulation of PTGS2 778 0.59 366.76 319.85 96.40
184 INT9999 Regulation of Gene_expression of IGHE 32 0.60 15.75 3.53 96.40
185 INT72798 Binding of ADA 12 0.47 7.84 3.39 96.32
186 INT70614 Gene_expression of FAS 118 0.75 112.33 19.01 96.20
187 INT18990 Positive_regulation of GRP 32 0.70 5.22 11.23 96.16
188 INT283514 Localization of NR1I2 2 0.74 3.15 0.87 96.16
189 INT18773 Localization of ALB 117 0.80 69.18 13.8 96.16
190 INT129015 Phosphorylation of Ngf 6 0.73 5.92 6.6 96.12
191 INT185181 Phosphorylation of Pth 2 0.64 1.51 0.3 96.08
192 INT115213 Regulation of SFTPA1 13 0.32 6.91 7.11 96.04
193 INT286172 Positive_regulation of Protein_catabolism of RLS 1 0.18 7.37 1.02 95.84
194 INT158998 Negative_regulation of PTPLA 4 0.41 4.33 0 95.84
195 INT125821 Regulation of Positive_regulation of IGHE 6 0.40 5.38 0.53 95.84
196 INT18032 Positive_regulation of Oprk1 108 0.70 30.78 89.7 95.76
197 INT11159 Gene_expression of EGFR 698 0.78 548.93 25.69 95.68
198 INT30312 Binding of Pdyn 30 0.37 4.2 18.23 95.68
199 INT201130 Localization of AES 31 0.63 25.45 5.12 95.68
200 INT170738 Binding of Icam1 23 0.37 25.49 4.09 95.60
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