D:Pulmonary Alveolar Proteinosis

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Disease Term
Synonyms ALVEOLAR PROTEINOSES PULMONARY, Alveolar Proteinosis, Alveolar Proteinosis Pulmonary, Pap Pulmonary Alveolar Proteinosis, PROTEINOSES PULMONARY ALVEOLAR, PROTEINOSIS PULMONARY ALVEOLAR, Pulmonary Alveolar Proteinoses, Pulmonary Alveolar Proteinosis Lung Alveolar Proteinosis
Documents 51
Hot Single Events 105
Hot Interactions 10

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Pulmonary Alveolar Proteinosis. They are ordered first by their relevance to Pulmonary Alveolar Proteinosis and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT205989 Binding of SLC7A7 and PDAP1 1 0.02 1.77 0 100.00
2 INT186712 INCENP Positive_regulation of PPARA 1 0.01 1.05 0.08 100.00
3 INT186729 Csf2 Positive_regulation of PPARA 1 0.06 1.04 0.08 100.00
4 INT227072 Binding of LTF and PTPRC 1 0.00 0.51 0.04 96.88
5 INT349221 CSF2 Regulation of Gene_expression of SLC7A7 1 0.10 0.18 0.04 96.72
6 INT349224 Binding of CSF2 and SLC7A7 1 0.12 0.38 0 93.92
7 INT215394 Binding of Csf2 and Positive_regulation of Ppara 1 0.12 0.49 0.14 91.12
8 INT215395 Csf2 Positive_regulation of Ppara 1 0.12 1.33 0.32 90.16
9 INT349223 CSF2 Positive_regulation of SLC7A7 1 0.17 0.3 0 89.84
10 INT349222 CSF2 Positive_regulation of Gene_expression of SLC7A7 1 0.17 0.4 0.13 89.52
11 INT349219 PTPRC Positive_regulation of Gene_expression of SLC3A2 1 0.11 0.53 0 79.36
12 INT186713 IK Positive_regulation of Gene_expression of NOS1 1 0.00 0.55 0.49 5.00
13 INT186711 IK Positive_regulation of Localization of IL8 1 0.00 0.39 0.44 5.00
14 INT215396 Il4 Positive_regulation of Gene_expression of Ppara 1 0.03 0.23 0.23 5.00
15 INT175464 Hand2 Positive_regulation of Gene_expression of Sftpd 1 0.19 1.05 0.2 5.00
16 INT331628 Binding of HLA-DQA2 and Pain1 1 0.01 2.13 0.14 5.00
17 INT331627 Binding of HLA-DRB3 and Pain1 1 0.00 2.15 0.14 5.00
18 INT331612 ETV4 Positive_regulation of Gene_expression of TGFB1 1 0.00 1.32 0.12 5.00
19 INT175463 Sftpd Negative_regulation of Gene_expression of Hand2 1 0.17 0.96 0.11 5.00
20 INT292328 Binding of Sds and Mb 1 0.11 0.24 0.1 5.00
21 INT331626 Edn1 Positive_regulation of Itk 1 0.00 0.57 0.07 5.00
22 INT331629 Binding of TGFB1 and Positive_regulation of Gene_expression of Itk 1 0.00 0.84 0.07 5.00
23 INT292334 Binding of Sds and Fig4 1 0.02 0.07 0.05 5.00
24 INT349220 Binding of CASP3 and CD8A 1 0.00 0.18 0 5.00
25 INT349225 TREM1 Positive_regulation of LAMB1 1 0.00 0 0 5.00
26 INT292330 Binding of Mb and Fig4 1 0.06 0 0 5.00
27 INT331611 NKX2-1 Regulation of Transcription of SFTPB 1 0.01 0.49 0 5.00
28 INT292326 Binding of Fig4 and LOC360919 1 0.00 0.08 0 5.00
29 INT292329 Binding of Sds and LOC360919 1 0.01 0.08 0 5.00
30 INT292327 Binding of Mb and LOC360919 1 0.01 0.08 0 5.00
31 INT186449 Binding of SFTPB and SFTPC 1 0.38 0.09 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Pulmonary Alveolar Proteinosis. They are ordered first by their pain relevance and then by number of times they were reported in Pulmonary Alveolar Proteinosis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT55002 Gene_expression of ASAP1 46 0.64 22.8 3.2 100.00
2 INT205995 Gene_expression of SLC7A7 11 0.75 10.61 1.21 100.00
3 INT9694 Positive_regulation of Csf2 102 0.68 70.09 33.07 100.00
4 INT92941 Binding of ASAP1 24 0.39 12.38 1.25 100.00
5 INT45167 Positive_regulation of ASAP1 32 0.60 17.09 1.84 100.00
6 INT25392 Positive_regulation of Gene_expression of Csf2 41 0.49 34.28 8.36 100.00
7 INT15801 Positive_regulation of TFRC 11 0.33 6.35 3.3 100.00
8 INT35132 Gene_expression of PDAP1 18 0.52 9.05 1.5 100.00
9 INT186460 Transcription of ASAP1 5 0.56 3.02 0.03 100.00
10 INT45168 Negative_regulation of ASAP1 23 0.58 10.15 2.44 100.00
11 INT205998 Binding of PDAP1 3 0.33 2.66 0.03 100.00
12 INT162006 Positive_regulation of Gene_expression of ASAP1 7 0.44 3.3 0.13 100.00
13 INT205992 Regulation of Gene_expression of SLC7A7 3 0.44 0.81 0 100.00
14 INT205997 Regulation of Gene_expression of SFTPB 1 0.44 0.71 0 100.00
15 INT205991 Negative_regulation of SLC7A7 9 0.41 1.81 0.12 100.00
16 INT15746 Negative_regulation of PDAP1 13 0.52 6.45 1.12 100.00
17 INT205993 Regulation of Localization of PDAP1 1 0.18 0.65 0 100.00
18 INT449 Localization of PDAP1 4 0.66 2.29 0.33 100.00
19 INT15686 Regulation of PDAP1 6 0.45 2 0.78 100.00
20 INT18881 Binding of Asap1 7 0.41 4.28 3.66 100.00
21 INT22429 Positive_regulation of PDAP1 34 0.61 22.58 2.91 100.00
22 INT20611 Gene_expression of Asap1 55 0.65 23.71 14.62 100.00
23 INT170281 Negative_regulation of Gene_expression of PDAP1 2 0.21 1.15 0.37 100.00
24 INT181396 Transcription of Csf2 15 0.48 6.38 2.17 100.00
25 INT159489 Positive_regulation of Positive_regulation of Csf2 6 0.42 6.02 1.61 100.00
26 INT206463 Positive_regulation of Positive_regulation of ASAP1 4 0.41 1.28 0.07 100.00
27 INT43947 Localization of ASAP1 11 0.68 4.49 0.88 100.00
28 INT14690 Localization of CSF2 124 0.80 85.17 27.26 99.96
29 INT25383 Gene_expression of Csf2 222 0.76 152.93 43.32 99.92
30 INT186450 Negative_regulation of SFTPB 17 0.58 10.94 0.31 99.84
31 INT22597 Positive_regulation of TF 43 0.68 27.27 5.17 99.84
32 INT52904 Positive_regulation of LTF 21 0.67 15.58 5.78 99.84
33 INT84825 Gene_expression of CD36 121 0.78 43.73 33.23 99.84
34 INT94285 Negative_regulation of CD36 10 0.43 6.61 1.98 99.84
35 INT205996 Binding of SLC7A7 2 0.13 0.82 0 99.80
36 INT9695 Negative_regulation of Csf2 41 0.57 31.65 6.28 99.76
37 INT84026 Positive_regulation of SLC7A7 8 0.67 3.12 0.33 99.76
38 INT186458 Negative_regulation of SFTPC 11 0.57 8.6 1.29 99.76
39 INT67614 Positive_regulation of PPARA 438 0.68 293.28 63.61 99.68
40 INT186456 Gene_expression of SFTPC 2 0.75 11.46 2.38 99.68
41 INT186463 Negative_regulation of Gene_expression of SFTPC 2 0.42 4.52 0.75 99.68
42 INT186459 Positive_regulation of SFTPC 4 0.45 4.64 0.36 99.56
43 INT122041 Binding of Ppara 308 0.48 189.17 51.48 99.52
44 INT25394 Negative_regulation of Gene_expression of Csf2 22 0.52 13.18 5.84 99.38
45 INT93860 Gene_expression of Srl 4 0.67 2.22 1.44 99.36
46 INT115386 Gene_expression of Ppara 779 0.77 549.99 128.36 99.32
47 INT28714 Negative_regulation of Csf3 10 0.41 6.9 1.6 99.28
48 INT46721 Regulation of Csf2 26 0.45 20.4 6.18 99.18
49 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 99.00
50 INT11685 Regulation of CSF2 99 0.59 58.82 15.9 99.00
51 INT75932 Binding of Csf2 45 0.37 33.2 8.01 98.92
52 INT162372 Positive_regulation of SFTPD 15 0.67 11.8 3.21 98.92
53 INT253424 Protein_catabolism of SFTPD 2 0.74 1.12 0.31 98.92
54 INT186452 Positive_regulation of SFTPB 7 0.47 6.43 0.03 98.88
55 INT15805 Gene_expression of TFRC 35 0.75 17.44 8.52 98.72
56 INT132149 Positive_regulation of Gene_expression of LTF 10 0.70 11.5 3.14 98.72
57 INT58365 Gene_expression of LTF 51 0.78 44.14 7.25 98.70
58 INT164189 Gene_expression of TREM1 82 0.62 60.77 5.85 98.64
59 INT13240 Gene_expression of TF 94 0.76 57.81 10.99 98.16
60 INT15798 Positive_regulation of Gene_expression of TFRC 9 0.46 4.99 1.42 98.04
61 INT54593 Positive_regulation of Gene_expression of TF 16 0.68 9.05 1.43 97.96
62 INT186461 Gene_expression of SFTPB 10 0.73 8.69 1.09 97.84
63 INT349239 Gene_expression of CAA 1 0.75 1.53 0 97.20
64 INT98072 Gene_expression of LAT 5 0.68 5.37 0.44 96.88
65 INT32344 Localization of LTF 30 0.80 15.28 10.09 96.88
66 INT11554 Negative_regulation of CSF2 129 0.59 108.55 29.44 96.00
67 INT69029 Gene_expression of PTPRC 127 0.75 74.26 11.57 95.28
68 INT122039 Positive_regulation of Gene_expression of Ppara 144 0.68 113.55 28.55 95.08
69 INT83332 Regulation of Gene_expression of TFRC 5 0.22 3.03 1.99 94.84
70 INT122037 Regulation of Ppara 93 0.62 56.28 12.89 94.80
71 INT46722 Regulation of Gene_expression of Csf2 8 0.45 4.84 1.45 94.64
72 INT329471 Positive_regulation of Gene_expression of SLC7A7 2 0.49 0.51 0.17 94.52
73 INT163613 Transcription of CSF2 16 0.60 12.98 1.62 94.28
74 INT4960 Positive_regulation of CSF2 285 0.70 256.73 65.73 94.24
75 INT89928 Gene_expression of CSF2RA 19 0.75 6.78 1.27 93.76
76 INT188034 Positive_regulation of Gene_expression of CSF2RA 2 0.45 1.24 0.15 93.60
77 INT96269 Positive_regulation of Mcpt1 71 0.61 52.38 20.4 93.48
78 INT329469 Negative_regulation of Positive_regulation of SLC7A7 2 0.36 0.59 0 93.24
79 INT349232 Positive_regulation of Gene_expression of LAT 1 0.27 0.99 0 92.96
80 INT22301 Positive_regulation of Gene_expression of CSF2 66 0.63 59.49 14.24 92.96
81 INT307615 Negative_regulation of Positive_regulation of CSF2 4 0.36 3.55 0.48 92.96
82 INT206025 Negative_regulation of Binding of Csf2 2 0.29 1.95 0.1 92.92
83 INT11560 Positive_regulation of CASP3 236 0.70 184.33 39.38 92.40
84 INT69437 Positive_regulation of ROS1 328 0.58 222.83 40.56 91.96
85 INT102658 Negative_regulation of Gene_expression of CSF2 42 0.50 38.63 8.32 91.84
86 INT349231 Negative_regulation of Gene_expression of LAT 1 0.23 0.58 0 91.84
87 INT73558 Regulation of IK 23 0.23 12.02 8.73 91.68
88 INT14301 Binding of CSF2 82 0.48 67.95 8.98 90.72
89 INT205994 Transcription of SLC7A7 2 0.70 1.44 0.05 89.68
90 INT36449 Negative_regulation of G6PD 74 0.59 54.15 8.85 89.60
91 INT102814 Negative_regulation of CASP3 46 0.43 28.54 6.94 89.32
92 INT186454 Binding of SFTPB 3 0.35 1.48 0.24 88.72
93 INT186464 Positive_regulation of Binding of TAB1 1 0.04 0.85 0 88.04
94 INT133078 Phosphorylation of STAT5B 5 0.69 1.15 1 87.28
95 INT349234 Gene_expression of SLC7A6 1 0.71 0.09 0.26 87.20
96 INT173445 Positive_regulation of TAB1 3 0.49 0.9 0 86.84
97 INT253422 Negative_regulation of Phosphorylation of STAT5B 2 0.23 0.45 0.04 86.16
98 INT186457 Binding of TAB1 3 0.47 1.53 0.18 85.52
99 INT53562 Negative_regulation of CSF2RA 3 0.56 0.76 0.04 85.36
100 INT7383 Localization of VIP 53 0.81 17.7 22.65 85.04
101 INT69436 Negative_regulation of Gene_expression of ROS1 81 0.38 46.58 12.22 83.56
102 INT69435 Negative_regulation of ROS1 74 0.51 50.38 13.71 83.56
103 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83 82.96
104 INT75933 Positive_regulation of Binding of Csf2 4 0.49 2.7 1.42 81.36
105 INT115385 Negative_regulation of Ppara 154 0.58 129.05 27.58 81.28
106 INT191542 Binding of ABCA3 1 0.22 1.61 0.03 79.00
107 INT11353 Gene_expression of SLC3A2 13 0.58 7.31 2.33 78.80
108 INT186451 Positive_regulation of Negative_regulation of SFTPB 1 0.47 0.52 0 78.12
109 INT2732 Gene_expression of VIP 74 0.78 24.57 33.72 73.12
110 INT89930 Regulation of CSF2RA 3 0.43 1.12 0.39 71.96
111 INT646 Binding of Mb 37 0.41 6.13 2.25 70.80
112 INT329470 Localization of SLC7A7 3 0.73 0.32 0.08 65.68
113 INT3395 Negative_regulation of VIP 15 0.59 4.23 5.62 59.60
114 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 57.76
115 INT186455 Localization of SFTPB 2 0.74 3.24 0.53 55.60
116 INT157666 Positive_regulation of GOPC 335 0.60 120.19 42.75 54.72
117 INT6481 Binding of TNF 624 0.48 510.2 214.82 54.32
118 INT86024 Gene_expression of PPARA 736 0.78 497.93 91.14 51.52
119 INT103094 Binding of PPARA 308 0.47 177.26 34.75 51.20
120 INT253425 Gene_expression of CSF2RB 4 0.46 4.88 0.73 50.00
121 INT224838 Positive_regulation of Transcription of Csf2 4 0.42 1.49 0.15 50.00
122 INT253423 Negative_regulation of CSF2RB 3 0.33 0.92 0.08 50.00
123 INT253426 Regulation of CSF2RB 1 0.21 0 0.04 50.00
124 INT253421 Negative_regulation of Negative_regulation of CSF2RA 1 0.41 0.07 0 50.00
125 INT132586 Negative_regulation of Hand2 40 0.30 26.58 9.28 44.88
126 INT173159 Localization of PPARA 96 0.74 64.55 10.26 39.76
127 INT90603 Positive_regulation of Ahr 103 0.69 58.65 7.73 38.48
128 INT104551 Gene_expression of Il18 156 0.76 115.51 36.95 34.64
129 INT141014 Positive_regulation of Gene_expression of Il18 46 0.68 47.63 13.3 34.64
130 INT60691 Gene_expression of Il12a 331 0.78 208.03 75.96 34.08
131 INT11807 Gene_expression of Il2 266 0.78 112 64.97 33.52
132 INT84546 Positive_regulation of Ppara 481 0.70 334.21 83.45 20.56
133 INT225661 Positive_regulation of PDHA1 10 0.46 2.38 0.09 14.80
134 INT108588 Gene_expression of CASP3 126 0.78 84.49 16.2 6.32
135 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
136 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
137 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 5.00
138 INT49441 Negative_regulation of Cpox 494 0.59 303.22 177.46 5.00
139 INT12339 Localization of IL8 437 0.81 251.87 117.39 5.00
140 INT62124 Gene_expression of NOS1 444 0.78 218.08 114.85 5.00
141 INT48593 Positive_regulation of NOS1 420 0.68 226.15 114.71 5.00
142 INT20374 Gene_expression of Il4 515 0.76 306.15 114.12 5.00
143 INT170025 Gene_expression of Fig4 588 0.67 183.27 113.32 5.00
144 INT1760 Gene_expression of PTGER2 524 0.57 226.94 96.4 5.00
145 INT56298 Gene_expression of IL4 306 0.78 182.18 72.92 5.00
146 INT171145 Positive_regulation of Fig4 274 0.59 93.55 69.81 5.00
147 INT3375 Gene_expression of IGHE 535 0.77 387.47 65.46 5.00
148 INT14740 Gene_expression of TGFB1 272 0.78 168.48 60.18 5.00
149 INT73048 Gene_expression of MMP9 268 0.77 159.75 57.81 5.00
150 INT4509 Gene_expression of IgG 426 0.76 293.69 56.64 5.00
151 INT96937 Gene_expression of Mmp9 191 0.75 150.3 56.01 5.00
152 INT251 Regulation of INS 398 0.62 232.47 55.04 5.00
153 INT62543 Gene_expression of Icam1 231 0.78 187.58 52.71 5.00
154 INT72182 Gene_expression of Mcpt1 167 0.75 123.7 52.15 5.00
155 INT52264 Gene_expression of IK 180 0.77 90.87 51.87 5.00
156 INT20382 Gene_expression of Hand2 211 0.66 142.26 51.05 5.00
157 INT170646 Negative_regulation of Fig4 213 0.37 81.29 46.92 5.00
158 INT3361 Positive_regulation of Esr1 273 0.69 208.53 44.81 5.00
159 INT115384 Positive_regulation of Mmp9 121 0.68 94.74 43.02 5.00
160 INT3987 Positive_regulation of IGHE 316 0.70 283.2 40.16 5.00
161 INT48222 Positive_regulation of Localization of IL8 123 0.59 78.04 37.2 5.00
162 INT20380 Gene_expression of Il5 172 0.78 104.75 34.78 5.00
163 INT67039 Positive_regulation of Cpox 144 0.65 98.4 33.77 5.00
164 INT73498 Gene_expression of IL13 117 0.44 83.85 32.26 5.00
165 INT13186 Positive_regulation of Il4 113 0.68 71.22 31.4 5.00
166 INT651 Positive_regulation of PTGS1 93 0.69 37.27 29.18 5.00
167 INT6364 Gene_expression of Edn1 123 0.78 73.76 28.43 5.00
168 INT69157 Gene_expression of IL5 127 0.77 102.58 26.81 5.00
169 INT2393 Positive_regulation of Mb 174 0.69 93.59 26.79 5.00
170 INT73670 Gene_expression of Vcam1 128 0.78 123.79 24.96 5.00
171 INT58301 Positive_regulation of Mpo 87 0.70 80.19 23.99 5.00
172 INT14731 Positive_regulation of TGFB1 78 0.67 52.57 22.23 5.00
173 INT14733 Positive_regulation of Gene_expression of TGFB1 71 0.69 49.89 22.2 5.00
174 INT84732 Positive_regulation of Hand2 81 0.69 62.07 22 5.00
175 INT73625 Gene_expression of PPARG 108 0.78 104.85 21.42 5.00
176 INT101517 Negative_regulation of PPARA 168 0.57 112.24 21.41 5.00
177 INT171820 Localization of Fig4 144 0.65 27.38 20.88 5.00
178 INT52106 Negative_regulation of Localization of IL8 57 0.52 22.81 20.8 5.00
179 INT12265 Positive_regulation of IgG 168 0.63 104.89 19.76 5.00
180 INT18311 Positive_regulation of CD8A 145 0.69 113.48 19.44 5.00
181 INT28215 Gene_expression of CDKN1A 196 0.76 113.9 18.3 5.00
182 INT61257 Gene_expression of Sele 79 0.77 70.97 17.78 5.00
183 INT12081 Localization of TGFB1 64 0.81 35.4 17.47 5.00
184 INT62546 Positive_regulation of Gene_expression of Icam1 60 0.70 59.52 16.9 5.00
185 INT22900 Positive_regulation of Cd4 126 0.67 82.77 16.43 5.00
186 INT9220 Gene_expression of Ighg1 125 0.77 85.74 15.92 5.00
187 INT19948 Gene_expression of Sds 34 0.63 14.69 15.44 5.00
188 INT170335 Gene_expression of INCENP 176 0.54 91.62 15.31 5.00
189 INT75502 Positive_regulation of CDKN1A 123 0.68 70.75 14.74 5.00
190 INT100139 Positive_regulation of Gene_expression of PPARA 160 0.63 97.78 14.53 5.00
191 INT142621 Positive_regulation of Gene_expression of CD36 38 0.70 15.18 13.4 5.00
192 INT39046 Positive_regulation of PTGER1 28 0.69 18.18 13.21 5.00
193 INT10016 Negative_regulation of CD8A 81 0.42 56.68 13.15 5.00
194 INT10870 Regulation of IgG 67 0.59 43.27 12.74 5.00
195 INT90909 Negative_regulation of Gene_expression of NOS1 44 0.55 23.83 12.47 5.00
196 INT3969 Positive_regulation of Sds 27 0.69 7.52 12.31 5.00
197 INT194462 Localization of Ppara 94 0.78 68.33 12.09 5.00
198 INT116433 Gene_expression of CYBB 93 0.70 50.44 11.91 5.00
199 INT93715 Negative_regulation of MMP9 69 0.55 36.05 11.73 5.00
200 INT2791 Regulation of Mb 53 0.61 23.03 10.73 5.00
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