D:Pulmonary Edema

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Disease Term
Synonyms EDEMA PULMONARY, Edemas Pulmonary, Lung Wet, LUNGS WET, Pulmonary Edemas, Wet Lung, Wet Lungs
Documents 45
Hot Single Events 44
Hot Interactions 2

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Pulmonary Edema. They are ordered first by their relevance to Pulmonary Edema and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT323640 Vcam1 Positive_regulation of Gene_expression of Icam1 1 0.42 1.75 0.08 89.48
2 INT222022 Binding of Mmp8 and Mmp9 1 0.28 1.98 0.15 84.00
3 INT347563 Abat Positive_regulation of Gopc 1 0.04 0.2 0.43 73.68
4 INT191792 Binding of F2r and Serpinc1 1 0.00 3.74 0.24 54.40
5 INT250781 IRF6 Positive_regulation of AMIGO2 1 0.02 1.25 0.35 16.88
6 INT222024 Mapk8 Regulation of Mapk14 2 0.17 0.83 0.79 5.00
7 INT244320 Tlr4 Positive_regulation of Aliq1 3 0.04 4.51 0.64 5.00
8 INT127320 Gpx3 Regulation of Akt1 2 0.00 3.11 0.53 5.00
9 INT222284 Negative_regulation of Casp1 Negative_regulation of Il18 1 0.01 0.79 0.46 5.00
10 INT222283 Negative_regulation of Casp1 Negative_regulation of Il1a 1 0.00 0.78 0.46 5.00
11 INT347562 Abat Positive_regulation of Mki67 1 0.03 0 0.3 5.00
12 INT191799 PROC Negative_regulation of Binding of F2r 1 0.00 0.92 0.3 5.00
13 INT258857 Binding of P2rx1 and P2ry2 1 0.22 0.81 0.29 5.00
14 INT258856 P2ry2 Positive_regulation of P9Ehs1 1 0.01 0.76 0.26 5.00
15 INT220681 Binding of F10 and tf 1 0.03 1.47 0.26 5.00
16 INT250783 APC Negative_regulation of SERPINE1 1 0.06 0.86 0.23 5.00
17 INT250782 APC Negative_regulation of F2 1 0.00 0.86 0.23 5.00
18 INT250779 PROC Regulation of IRF6 Positive_regulation of AMIGO2 1 0.00 0.74 0.22 5.00
19 INT281351 Tenc1 Regulation of Agtr2 1 0.06 0.8 0.21 5.00
20 INT220676 tf Positive_regulation of Gene_expression of Ik 1 0.00 0.66 0.21 5.00
21 INT220678 Positive_regulation of Binding of tf and Par2 1 0.16 0.71 0.2 5.00
22 INT220683 Binding of tf and PAR1 1 0.06 0.7 0.2 5.00
23 INT220674 Binding of tf and Par2 1 0.13 0.71 0.2 5.00
24 INT220682 tf Positive_regulation of Positive_regulation of F10 1 0.04 0.67 0.19 5.00
25 INT220673 Binding of tf and Gtf3a Positive_regulation of F10 1 0.00 0.67 0.19 5.00
26 INT316203 Ghsr Positive_regulation of Transcription of Agrp 1 0.02 1.5 0.19 5.00
27 INT220675 Binding of tf and Gtf3a 1 0.02 0.67 0.19 5.00
28 INT222025 Gpx3 Regulation of EPHB2 1 0.01 1.41 0.18 5.00
29 INT222023 Gpx3 Regulation of Mapk8 1 0.01 1.43 0.18 5.00
30 INT220679 Binding of F3 and Gtf3a 1 0.00 0.98 0.15 5.00
31 INT352217 Tlr4 Positive_regulation of Binding of Tbce 1 0.03 0.8 0.07 5.00
32 INT222295 Binding of CPP and Cebpz 1 0.00 0.73 0.05 5.00
33 INT352216 Binding of Tlr4 and Tbce 1 0.01 0.3 0.04 5.00
34 INT250780 IRF6 Positive_regulation of ASAP1 1 0.06 0.34 0.04 5.00
35 INT220677 Binding of Mfi2 and Gtf3a 1 0.00 0.77 0.04 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Pulmonary Edema. They are ordered first by their pain relevance and then by number of times they were reported in Pulmonary Edema. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT250790 Negative_regulation of Localization of APC 2 0.13 2.3 0.13 100.00
2 INT54701 Localization of Ptafr 19 0.49 18.68 3.82 99.76
3 INT195672 Localization of APC 7 0.74 3.76 0.3 99.68
4 INT250792 Positive_regulation of Localization of APC 1 0.15 0.48 0.13 99.68
5 INT191783 Positive_regulation of Pnp 21 0.67 22.51 1.66 99.10
6 INT1273 Gene_expression of Avp 356 0.78 90.56 138.7 99.04
7 INT22548 Positive_regulation of Casp3 483 0.70 258.78 213.07 98.64
8 INT14151 Gene_expression of Casp3 311 0.78 140.26 120.68 98.64
9 INT22546 Positive_regulation of Gene_expression of Casp3 97 0.70 47.89 51.92 98.64
10 INT22973 Gene_expression of Col3a1 22 0.42 15.85 4.32 98.20
11 INT69181 Positive_regulation of Col3a1 10 0.33 5.54 1.91 98.20
12 INT125709 Positive_regulation of Gene_expression of Col3a1 7 0.27 5.17 0.65 98.20
13 INT49750 Negative_regulation of CPOX 735 0.58 360.06 274.19 97.84
14 INT111241 Negative_regulation of Localization of Elane 1 0.57 0.59 0.15 97.44
15 INT99348 Negative_regulation of PARP1 38 0.58 30.96 3.36 97.08
16 INT48406 Gene_expression of Icam1 277 0.78 238.28 81.71 97.00
17 INT48407 Positive_regulation of Gene_expression of Icam1 61 0.70 57.91 21.54 97.00
18 INT51017 Positive_regulation of Icam1 113 0.70 81.16 35.55 97.00
19 INT111240 Localization of Elane 1 0.78 0.59 0.15 96.88
20 INT61519 Gene_expression of Mpo 112 0.78 89.29 18.22 96.48
21 INT49993 Positive_regulation of Gene_expression of Il6 149 0.70 88.07 53.78 96.16
22 INT4534 Regulation of PROC 38 0.33 19.81 8.99 96.08
23 INT10173 Binding of Tnf 45 0.48 35.6 14.32 96.00
24 INT16868 Gene_expression of Il6 807 0.78 499.48 256.57 95.68
25 INT191776 Regulation of Gene_expression of Pnp 3 0.06 2.11 0 95.32
26 INT191772 Regulation of Pnp 1 0.06 1.05 0 95.32
27 INT49105 Gene_expression of Vcam1 157 0.78 157.27 43.01 95.08
28 INT49104 Positive_regulation of Gene_expression of Vcam1 30 0.69 36.52 7.64 95.08
29 INT49103 Positive_regulation of Vcam1 71 0.69 59.52 19.85 95.08
30 INT105609 Negative_regulation of Mc4r 10 0.58 10.4 5.04 94.76
31 INT156874 Positive_regulation of Gene_expression of S100a8 26 0.49 32.8 8.99 94.60
32 INT56687 Gene_expression of Pnp 19 0.49 11.75 2.08 94.52
33 INT82448 Gene_expression of S100a8 246 0.77 236.72 84.02 94.20
34 INT23226 Positive_regulation of tf 23 0.43 15.55 14.37 89.56
35 INT2431 Positive_regulation of Mpo 275 0.70 211.99 78.47 85.52
36 INT5653 Positive_regulation of ELANE 136 0.70 72.78 27.94 85.52
37 INT111412 Positive_regulation of Sftpb 2 0.67 1.02 0.04 84.56
38 INT5033 Negative_regulation of tf 39 0.54 13.37 48.62 84.04
39 INT15941 Negative_regulation of Serpine1 42 0.58 21.07 4.95 84.04
40 INT227437 Positive_regulation of CSR 1 0.30 1.81 0 84.00
41 INT155780 Gene_expression of Mmp8 19 0.77 15.85 6.33 82.44
42 INT113606 Positive_regulation of Gene_expression of Mmp9 46 0.64 44 15.07 81.76
43 INT96937 Gene_expression of Mmp9 191 0.75 150.3 56.01 81.36
44 INT115384 Positive_regulation of Mmp9 121 0.68 94.74 43.02 80.16
45 INT169926 Positive_regulation of Gopc 416 0.46 157.8 58.67 79.84
46 INT9647 Gene_expression of PROC 163 0.65 89.76 26.75 78.48
47 INT71868 Regulation of Tenc1 9 0.52 10.73 4.09 76.04
48 INT58301 Positive_regulation of Mpo 87 0.70 80.19 23.99 75.92
49 INT35548 Regulation of Mme 9 0.45 10.62 2.97 75.84
50 INT284156 Positive_regulation of Negative_regulation of F2 1 0.01 1.71 0.15 75.52
51 INT17501 Negative_regulation of F2 70 0.58 32.23 7.51 75.52
52 INT222017 Regulation of Gene_expression of Mmp8 1 0.27 1 0.04 75.00
53 INT184257 Positive_regulation of Gene_expression of Mmp8 7 0.49 6.32 2.74 74.60
54 INT4047 Binding of F13A1 105 0.43 66.54 11.81 73.44
55 INT74447 Gene_expression of Vwf 39 0.76 21.96 4.66 73.24
56 INT720 Positive_regulation of POMC 807 0.70 237.37 353.83 73.00
57 INT23589 Positive_regulation of CALCR 9 0.67 6.73 1.25 72.96
58 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 72.36
59 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 72.36
60 INT94119 Localization of Tnfrsf1b 8 0.75 5.66 2.42 71.68
61 INT11937 Localization of Il6 228 0.81 139.83 64.39 70.24
62 INT11938 Positive_regulation of Localization of Il6 61 0.70 35.72 18.25 70.24
63 INT1767 Positive_regulation of PROC 83 0.67 54.14 17 68.92
64 INT49532 Regulation of Gene_expression of Il6 43 0.61 25.8 14.99 68.68
65 INT227434 Binding of CSR 1 0.21 1.22 0 68.40
66 INT8243 Positive_regulation of Il6 451 0.70 358.24 119.28 68.24
67 INT124976 Positive_regulation of Tnfrsf1b 15 0.67 14.92 5.15 68.24
68 INT18778 Gene_expression of Ugt1a2 17 0.35 9.91 6.87 68.08
69 INT178306 Negative_regulation of Gene_expression of Gopc 71 0.37 26.43 9.74 66.84
70 INT220667 Negative_regulation of Gene_expression of Vwf 2 0.18 1 0.07 66.84
71 INT22045 Gene_expression of IRF6 158 0.75 58.07 27.81 66.52
72 INT76096 Positive_regulation of Gene_expression of IRF6 37 0.49 14.24 6.39 66.52
73 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 66.36
74 INT60187 Positive_regulation of Lbm1 2 0.43 11.43 0.36 64.80
75 INT96915 Phosphorylation of Mapk8 73 0.81 40.69 11.44 64.12
76 INT96914 Phosphorylation of Mapk14 168 0.82 108.46 53.32 64.12
77 INT52712 Negative_regulation of PRKCA 64 0.57 23.11 28.43 63.84
78 INT5539 Negative_regulation of Mme 75 0.59 28.91 41.84 63.16
79 INT52800 Negative_regulation of Gene_expression of Tnf 142 0.59 92.27 55.47 62.56
80 INT178391 Localization of Mapk14 9 0.68 5.27 0.97 62.36
81 INT165105 Localization of Mapk8 7 0.69 4.45 0.76 62.36
82 INT9158 Gene_expression of Tnf 722 0.78 522.01 277.68 62.08
83 INT6852 Localization of TNF 883 0.81 705.95 270.84 61.76
84 INT22112 Positive_regulation of Localization of TNF 164 0.70 115.66 52.18 61.76
85 INT51265 Phosphorylation of TNF 32 0.81 25.33 10.75 61.32
86 INT14902 Negative_regulation of XDH 38 0.55 24.19 2.86 61.24
87 INT122290 Regulation of Gene_expression of Vcam1 9 0.42 7.15 2.26 60.96
88 INT65429 Transcription of Vcam1 4 0.69 7.4 0.64 60.96
89 INT135470 Transcription of Icam1 10 0.63 12.04 2.41 60.24
90 INT58400 Negative_regulation of Tnf 182 0.59 129.97 71 59.92
91 INT217393 Negative_regulation of Gene_expression of Mme 3 0.43 5.98 0.46 59.48
92 INT15054 Gene_expression of Mme 48 0.77 42.52 10.63 58.84
93 INT110020 Gene_expression of Mapk14 142 0.77 72.33 30.08 57.96
94 INT45168 Negative_regulation of ASAP1 23 0.58 10.15 2.44 57.76
95 INT220151 Negative_regulation of Lbm1 4 0.09 4.34 0.83 57.04
96 INT316206 Negative_regulation of H19 1 0.01 1.07 0 57.04
97 INT316207 Negative_regulation of Positive_regulation of H19 1 0.01 1.07 0 57.04
98 INT185929 Regulation of Gene_expression of IRF6 9 0.20 1.66 0.99 56.96
99 INT316204 Positive_regulation of H19 1 0.01 1.07 0 56.72
100 INT9236 Regulation of Gene_expression of TNF 204 0.62 162.66 72.99 56.44
101 INT10166 Localization of Tnf 237 0.81 153.95 88.64 54.32
102 INT123988 Regulation of Agrp 11 0.60 5.92 3.82 54.00
103 INT89132 Regulation of NOS2 9 0.61 7.34 4.95 51.72
104 INT9658 Negative_regulation of Gene_expression of Il6 110 0.59 66.29 32.58 50.04
105 INT9657 Positive_regulation of Gene_expression of Il6 237 0.70 180.45 63.6 49.56
106 INT97912 Gene_expression of Sod3 25 0.78 22.44 3.28 48.80
107 INT48895 Gene_expression of Il10 333 0.78 221.2 138.52 46.56
108 INT66026 Gene_expression of Cxcl1 74 0.78 31.87 23.37 46.56
109 INT222013 Protein_catabolism of Mmp8 2 0.65 0.96 0.18 45.16
110 INT316199 Localization of Lbm1 1 0.12 0.9 0.04 44.96
111 INT191794 Positive_regulation of ALLC 3 0.11 2.16 0.16 44.56
112 INT36263 Positive_regulation of CEL 53 0.69 34.88 12.87 43.68
113 INT50670 Gene_expression of CPOX 763 0.76 442.13 195.02 42.40
114 INT117147 Negative_regulation of Gene_expression of Cxcl2 19 0.55 15.33 6.57 42.28
115 INT83953 Gene_expression of Cxcl2 140 0.75 113.07 43.65 41.40
116 INT258848 Regulation of Gene_expression of Cxcl2 7 0.43 8.71 1.77 41.40
117 INT250789 Positive_regulation of Negative_regulation of PFDN4 1 0.45 0.46 0 40.92
118 INT35143 Negative_regulation of ANGPTL5 28 0.54 18.59 3.14 40.64
119 INT250791 Negative_regulation of PFDN4 1 0.57 0.46 0 40.64
120 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 40.32
121 INT25610 Positive_regulation of Gene_expression of Il1 136 0.67 104.43 43.86 39.92
122 INT19472 Gene_expression of Il1 554 0.76 419.75 175.35 39.60
123 INT191782 Gene_expression of Cel 1 0.04 2.88 0.77 39.52
124 INT8684 Positive_regulation of ANGPTL5 45 0.69 36.29 7.47 38.92
125 INT80674 Negative_regulation of Gene_expression of APC 16 0.59 18.14 0.69 38.56
126 INT191797 Negative_regulation of Gene_expression of CALCR 2 0.03 1.37 0.17 38.56
127 INT39820 Gene_expression of CALCR 16 0.37 4.96 0.74 38.00
128 INT57057 Gene_expression of APC 131 0.78 122.24 8.7 37.68
129 INT316200 Regulation of Negative_regulation of Mc4r 1 0.43 1.05 0.03 37.64
130 INT316198 Gene_expression of Lbm1 1 0.10 0.53 0 37.24
131 INT113734 Gene_expression of Agrp 31 0.77 11.04 9.02 36.20
132 INT39516 Gene_expression of Alb 81 0.75 30.08 6.59 35.96
133 INT200552 Regulation of Aliq1 3 0.08 7.55 1.42 35.28
134 INT97910 Positive_regulation of Gene_expression of Sod3 13 0.70 15.56 2.46 34.56
135 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 27.96
136 INT899 Gene_expression of F13A1 122 0.70 78.02 16.26 27.64
137 INT6481 Binding of TNF 624 0.48 510.2 214.82 27.28
138 INT191781 Binding of Cel 1 0.02 0.62 0.21 27.28
139 INT222294 Positive_regulation of Transcription of Trim63 2 0.36 0.17 0 27.04
140 INT222292 Transcription of Trim63 3 0.52 0.32 0 27.04
141 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 26.96
142 INT191784 Positive_regulation of Cel 4 0.03 3.18 1.16 26.96
143 INT191780 Positive_regulation of Gene_expression of Cel 1 0.03 1.48 0.6 26.96
144 INT222291 Positive_regulation of Trim63 3 0.50 0.94 0.04 26.64
145 INT10101 Binding of PLAT 24 0.36 12.62 2.78 25.52
146 INT22679 Binding of SERPINE1 25 0.36 17.33 2.36 25.52
147 INT177481 Negative_regulation of BBS2 6 0.31 5.34 1.06 24.88
148 INT284157 Regulation of Negative_regulation of BBS2 1 0.08 1.08 0.21 24.88
149 INT138784 Positive_regulation of Gene_expression of Lcn2 3 0.49 4.44 1.13 24.84
150 INT89131 Negative_regulation of NOS2 20 0.58 9.68 6.56 24.32
151 INT220861 Positive_regulation of Mmp8 14 0.50 12.21 4.6 24.32
152 INT278983 Regulation of Negative_regulation of NOS2 1 0.17 1.71 0.53 24.32
153 INT138785 Gene_expression of Lcn2 9 0.56 9.88 2.41 24.16
154 INT191770 Positive_regulation of Positive_regulation of Pnp 1 0.07 1.35 0.14 23.64
155 INT191795 Localization of ALLC 1 0.05 0.65 0.24 23.00
156 INT171070 Positive_regulation of Hey2 8 0.05 10.12 1.96 21.64
157 INT37377 Negative_regulation of Binding of Mme 2 0.38 1.79 0.88 21.32
158 INT227435 Positive_regulation of Binding of CSR 1 0.22 0 0 21.20
159 INT35910 Binding of Mme 8 0.37 4.79 3.16 20.68
160 INT90771 Positive_regulation of Ptprc 20 0.48 8.43 1.27 18.40
161 INT16461 Negative_regulation of Gene_expression of PROC 13 0.24 4.39 2.17 17.84
162 INT50272 Positive_regulation of Cotl1 24 0.40 6.57 2.77 16.80
163 INT297904 Positive_regulation of Foxo3 6 0.57 8.19 0.29 16.80
164 INT15769 Gene_expression of Il1b 146 0.78 114.51 75.35 15.32
165 INT174684 Gene_expression of Tlr6 2 0.44 2.62 0.36 15.32
166 INT111680 Gene_expression of P2ry2 20 0.58 9.23 7.39 15.04
167 INT130203 Gene_expression of P2ry4 14 0.50 8.79 4.82 15.04
168 INT140794 Gene_expression of Smad3 22 0.64 9.41 0.83 14.12
169 INT109316 Negative_regulation of Mapk8 72 0.59 50.59 17.24 13.84
170 INT137007 Gene_expression of SMAD2 6 0.75 2.53 0.75 13.64
171 INT11313 Positive_regulation of Il6 526 0.70 331.27 201.59 13.60
172 INT222020 Positive_regulation of Gadd45a 1 0.47 0.38 0.19 11.64
173 INT74272 Localization of CPOX 39 0.63 25.12 10.53 11.20
174 INT184720 Negative_regulation of Smad3 8 0.55 5.23 1.1 10.24
175 INT184722 Positive_regulation of Smad3 3 0.47 1.22 0.03 8.96
176 INT157804 Phosphorylation of Smad3 18 0.77 8.15 0.35 8.56
177 INT157797 Negative_regulation of Phosphorylation of Smad3 3 0.40 0.95 0.17 8.56
178 INT5969 Gene_expression of Il1a 221 0.75 96.31 71.38 8.20
179 INT3439 Localization of Abat 1017 0.78 112.39 727.06 5.00
180 INT886 Gene_expression of Pomc 676 0.78 129.87 295.98 5.00
181 INT2909 Positive_regulation of Abat 334 0.70 62.1 256.43 5.00
182 INT9987 Gene_expression of Abat 296 0.78 95.46 226.34 5.00
183 INT95787 Positive_regulation of Mapk1 568 0.70 226.51 220.94 5.00
184 INT48955 Gene_expression of Nos2 753 0.78 403.87 208.08 5.00
185 INT2211 Negative_regulation of Abat 267 0.59 66.51 200.98 5.00
186 INT6488 Gene_expression of Tnf 484 0.78 339.61 191.58 5.00
187 INT6354 Localization of Gabrg1 321 0.74 41.41 186.74 5.00
188 INT14843 Gene_expression of Gabrg1 301 0.77 62.63 139.16 5.00
189 INT48953 Positive_regulation of Nos2 486 0.70 239.85 131.87 5.00
190 INT5008 Localization of Calca 204 0.81 80.35 125.16 5.00
191 INT6323 Positive_regulation of Gabrg1 213 0.70 45.08 124.34 5.00
192 INT7533 Gene_expression of Tlr4 720 0.78 343.22 121.57 5.00
193 INT96917 Positive_regulation of Mapk14 261 0.70 173.29 88.79 5.00
194 INT56291 Gene_expression of Ros1 503 0.63 274.12 81.5 5.00
195 INT64636 Positive_regulation of Gene_expression of Nos2 242 0.70 147.52 79.53 5.00
196 INT19511 Localization of Il6 212 0.81 118.17 67.67 5.00
197 INT2212 Binding of Abat 89 0.48 18.36 63.99 5.00
198 INT4509 Gene_expression of IgG 426 0.76 293.69 56.64 5.00
199 INT48952 Negative_regulation of Nos2 204 0.59 101.73 53.15 5.00
200 INT12345 Gene_expression of Il2 142 0.78 59.17 51.21 5.00
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