D:Pulmonary Fibrosis

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pChart

Disease Term
Synonyms Alveolitides Fibrosing, Alveolitis Fibrosing, Cirrhosis Of Lung, Cryptogenic Fibrosing Alveolitis, Fibroses Pulmonary, FIBROSING ALVEOLITIDES, Fibrosing Alveolitis, Fibrosis Of Lung, Fibrosis Pulmonary, Hamman Rich Syndrome, Idiopathic Pulmonary Fibrosis
Documents 446
Hot Single Events 200
Hot Interactions 52

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Pulmonary Fibrosis. They are ordered first by their relevance to Pulmonary Fibrosis and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT185809 Binding of PDX1 and SPP1 1 0.02 1.69 0.57 100.00
2 INT185806 Binding of PDX1 and MMP7 1 0.02 0.84 0.28 100.00
3 INT185802 Binding of MMP7 and SPP1 1 0.33 1.71 0.68 99.90
4 INT185813 Binding of MMP7 and Positive_regulation of SPP1 1 0.46 0.85 0.28 99.90
5 INT192332 UBR7 Negative_regulation of TXK 1 0.00 1.38 0.63 99.72
6 INT185805 SPP1 Regulation of MMP7 1 0.25 0.38 0.19 99.68
7 INT263048 Tgfb1 Positive_regulation of Gene_expression of Mmp2 1 0.13 0.81 1.07 99.34
8 INT263049 Positive_regulation of Binding of Mmp2 and Mmp9 1 0.35 0.83 0.69 98.48
9 INT250777 Binding of Cxcl10 and Cxcr1 1 0.14 3.1 1.04 98.44
10 INT171049 Binding of FAS and Positive_regulation of Gene_expression of CASP3 1 0.04 1.41 0.24 98.28
11 INT333398 CFD Negative_regulation of Gene_expression of Pdgfa 1 0.02 0.64 0.3 98.20
12 INT102160 Binding of Mmp2 and Mmp9 3 0.28 2.87 1.75 97.88
13 INT310727 Binding of DKC1 and TERT 1 0.23 0.91 0.05 97.60
14 INT332248 Ccl2 Positive_regulation of Ctgf 1 0.04 1.13 0.42 97.20
15 INT335996 Mmp8 Regulation of Protein_catabolism of MIP 1 0.44 1.06 0.43 97.00
16 INT187818 Gene_expression of Il10 Positive_regulation of Gene_expression of Il4 1 0.09 0.69 0.35 96.72
17 INT185800 SPP1 Negative_regulation of Gene_expression of MMP1 1 0.26 1.03 0.49 94.80
18 INT332255 Ptger2 Positive_regulation of Localization of Col7a1 1 0.00 0.92 0.31 94.68
19 INT335456 Binding of PDX1 and hb 1 0.02 2.59 0.66 94.60
20 INT335455 Negative_regulation of Binding of PDX1 and hb 1 0.02 1.3 0.33 94.60
21 INT185804 MMP2 Positive_regulation of SPP1 1 0.15 0.88 0.37 94.48
22 INT185798 SPP1 Positive_regulation of Gene_expression of MMP2 1 0.26 0.87 0.37 94.48
23 INT185818 SPP1 Positive_regulation of Gene_expression of COL7A1 1 0.10 0.82 0.28 94.48
24 INT332246 Ros1 Positive_regulation of Stat1 1 0.02 0.46 0.27 94.40
25 INT185799 Binding of EGFR and SPP1 1 0.19 0.64 0.29 94.24
26 INT133307 Binding of CD44 and SPP1 5 0.26 2.6 0.35 94.24
27 INT322206 CCL18 Positive_regulation of Gene_expression of COL7A1 1 0.05 0.28 0.05 93.04
28 INT185816 SPP1 Positive_regulation of Positive_regulation of MMP7 1 0.46 0.36 0.18 92.08
29 INT316813 Sparc Negative_regulation of Gene_expression of Col1a1 1 0.13 0.67 0.12 90.00
30 INT332254 Pdgfa Positive_regulation of Stat3 1 0.02 0.52 0.14 89.68
31 INT181995 TIMP1 Negative_regulation of Mmp9 1 0.01 1.38 0.4 89.60
32 INT335993 Mmp8 Regulation of Il10 1 0.25 0.36 0.11 89.60
33 INT332243 Pdgfa Positive_regulation of Stat1 1 0.06 0.52 0.14 88.80
34 INT240484 Ctsk Positive_regulation of Protein_catabolism of Col7a1 1 0.12 0.42 0.07 88.52
35 INT185811 SPP1 Positive_regulation of MMP3 1 0.14 0.83 0.38 88.24
36 INT185814 Binding of MMP3 and SPP1 1 0.15 0.83 0.38 88.24
37 INT332242 Binding of Egf and Pdgfa 1 0.07 0.97 0.25 87.24
38 INT332256 Pdgfa Positive_regulation of SOAT1 1 0.01 0.51 0.14 87.04
39 INT331629 Binding of TGFB1 and Positive_regulation of Gene_expression of Itk 1 0.00 0.84 0.07 86.28
40 INT335994 Timp1 Regulation of Col7a1 1 0.01 0.36 0.37 85.92
41 INT185807 SPP1 Positive_regulation of MMP7 1 0.56 0.79 0.36 84.88
42 INT185795 MMP7 Positive_regulation of SPP1 1 0.38 0.81 0.37 84.36
43 INT266393 Binding of Ager and Fn1 1 0.00 0.82 0.39 84.00
44 INT266382 Binding of Col4a1 and Fn1 1 0.00 0.82 0.39 84.00
45 INT202313 Gene_expression of PDGFB Positive_regulation of Positive_regulation of Pdgfrb 1 0.14 1 0.29 83.84
46 INT202314 Gene_expression of PDGFB Positive_regulation of Phosphorylation of Pdgfrb 1 0.14 1 0.29 83.84
47 INT302421 IFNA1 Positive_regulation of Cxcl10 1 0.02 1.8 0.45 82.56
48 INT302422 IFNA1 Positive_regulation of Cxcl9 1 0.03 1.81 0.45 82.56
49 INT185803 Binding of MMP11 and SPP1 1 0.06 0.34 0.17 82.32
50 INT266397 Binding of Ager and Col4a1 1 0.00 0.81 0.38 81.60
51 INT185810 Binding of MMP2 and SPP1 1 0.14 0.34 0.17 81.36
52 INT185815 Binding of MMP1 and SPP1 1 0.21 0.34 0.17 80.80
53 INT302423 Etohi5 Positive_regulation of IFNA1 1 0.00 1.77 0.44 79.16
54 INT202312 PDGFB Positive_regulation of Gene_expression of Col7a1 1 0.01 0.7 0.16 78.12
55 INT202311 PDGFB Positive_regulation of Gene_expression of Fn1 1 0.02 0.7 0.16 78.12
56 INT243044 Mmp8 Regulation of Mmp9 1 0.05 1.45 0.91 76.16
57 INT183695 Binding of Tlr3 and Ducm1 1 0.04 2.75 0.56 75.60
58 INT183700 Binding of Pilra and Ducm1 1 0.00 2.35 0.53 75.60
59 INT285939 IL6 Positive_regulation of TEP1 1 0.01 1.76 0.61 74.96
60 INT184120 Il4 Positive_regulation of Stat6 3 0.09 2.39 0.67 74.92
61 INT332247 Egf Positive_regulation of Stat6 1 0.13 1.23 0.19 74.92
62 INT332253 Il13 Positive_regulation of Stat6 1 0.08 1.18 0.19 74.92
63 INT332245 Pdgfa Positive_regulation of Stat6 1 0.07 1.22 0.19 74.92
64 INT332251 Il13 Positive_regulation of Stat1 1 0.14 1.4 0.18 74.80
65 INT179432 Binding of pcp and AICDA 1 0.03 3.51 0.43 74.56
66 INT180928 Binding of Col7a1 and Mmp9 1 0.03 0.96 0.32 74.16
67 INT269013 Binding of CSRP1 and COPD 1 0.08 1.3 0.11 74.12
68 INT185793 SPP1 Positive_regulation of COL1A2 1 0.16 0.33 0.16 74.04
69 INT185808 SPP1 Positive_regulation of TIMP1 1 0.64 0.33 0.16 74.04
70 INT223084 Binding of Pdgfa and Pdgfb 2 0.17 0.83 0.13 73.44
71 INT279410 Binding of MTRF1 and IGKV2-19 1 0.00 0.63 0.15 73.16
72 INT279408 Binding of CRYGD and IGKV2-19 1 0.00 0.4 0.1 73.16
73 INT279409 Binding of CRP and IGKV2-19 1 0.02 0.4 0.1 73.16
74 INT279407 Binding of ESR1 and IGKV2-19 1 0.02 0.4 0.1 73.16
75 INT153289 Binding of Lpar1 and Gpr87 2 0.29 1.19 0.67 73.04
76 INT153288 Binding of Lpar1 and Lpar6 2 0.31 0.78 0.36 73.04
77 INT262618 Binding of SOAT1 and Kras 1 0.00 0.81 0.12 72.72
78 INT192331 UBR7 Negative_regulation of INSRR 1 0.00 0.54 0.23 71.52
79 INT322208 HRCT1 Positive_regulation of PDX1 1 0.01 1.31 0.34 71.52
80 INT192330 UBR7 Negative_regulation of Positive_regulation of PDGFRB 1 0.01 0.54 0.12 69.96
81 INT250778 Binding of Socs3 and Atl1 1 0.01 0.6 0.14 69.60
82 INT335458 hb Positive_regulation of SRA1 1 0.00 0.87 0.25 68.00
83 INT171050 Negative_regulation of F13A1 Regulation of PLG 1 0.02 0.55 0.28 67.28
84 INT171048 F13A1 Regulation of PLG 1 0.02 0.55 0.27 67.28
85 INT335995 Il10 Negative_regulation of Tgfb1 1 0.06 0.83 0.57 67.00
86 INT332244 Il13 Positive_regulation of Gtf3a 1 0.01 1.21 0.15 66.84
87 INT264134 Binding of IFNA1 and Tlr4 1 0.01 1.5 0.22 65.76
88 INT345157 Lpar1 Positive_regulation of Gene_expression of Gtf3a 1 0.00 0.89 0.15 63.04
89 INT276948 Tlr2 Negative_regulation of Gene_expression of Tlr4 1 0.25 1.06 0.14 62.80
90 INT192329 UBR7 Negative_regulation of Phosphorylation of PDGFRB 1 0.01 0.06 0.07 59.36
91 INT183708 Tlr3 Regulation of Binding of Tlr3 and Ducm1 1 0.02 0.99 0.14 59.12
92 INT215395 Csf2 Positive_regulation of Ppara 1 0.12 1.33 0.32 57.68
93 INT185385 Binding of TLR2 and TLR4 3 0.27 3.63 0.32 52.40
94 INT331612 ETV4 Positive_regulation of Gene_expression of TGFB1 1 0.00 1.32 0.12 52.08
95 INT332250 Stat6 Positive_regulation of Gene_expression of Pdgfa 1 0.05 1.33 0.12 49.60
96 INT265048 INCENP Positive_regulation of Positive_regulation of Nfasc 1 0.00 0.69 0.19 49.44
97 INT332252 Stat6 Positive_regulation of Gene_expression of Il13 1 0.08 1.32 0.12 48.96
98 INT266395 Renbp Positive_regulation of Ager 1 0.00 0.31 0 48.40
99 INT299158 Binding of Lgals3 and Renbp 1 0.00 0.64 0.11 47.92
100 INT244689 Mmp16 Regulation of Mmp2 1 0.18 0.17 0 46.00
101 INT208263 Binding of Sdc1 and Msn 1 0.08 0.15 0 45.20
102 INT244243 Regulation of Binding of IL8 and Ccl3 1 0.04 0.05 0.18 44.44
103 INT244240 Binding of IL8 and Ccr5 1 0.03 0.05 0.18 44.44
104 INT244241 Binding of IL8 and Ccl3 1 0.05 0.05 0.18 44.44
105 INT244242 Negative_regulation of Binding of IL8 and Ccl3 1 0.06 0.05 0.18 44.44
106 INT208264 Park7 Negative_regulation of Pten 1 0.16 1.16 0.15 43.84
107 INT215394 Binding of Csf2 and Positive_regulation of Ppara 1 0.12 0.49 0.14 43.44
108 INT181450 Binding of Ccr5 and Ccl3 4 0.18 2.19 1.03 42.04
109 INT192333 PDGFA Positive_regulation of Gene_expression of FN1 2 0.11 1.26 0.18 40.32
110 INT262620 Renbp Positive_regulation of Ager Positive_regulation of Rpe 1 0.00 0.81 0 37.24
111 INT262617 Ager Positive_regulation of Rpe 1 0.00 0.81 0 36.64
112 INT276964 Binding of Tlr1 and Tlr2 11 0.24 4.22 0.89 33.36
113 INT276988 Binding of Tlr6 and Tlr2 11 0.26 4.89 0.79 33.36
114 INT276958 Binding of Tlr2 and Clec7a 1 0.09 0.58 0.15 33.36
115 INT276980 Binding of Tlr2 and Gopc 1 0.14 0.28 0.07 27.16
116 INT269313 Binding of Ptafr and Gp6 1 0.00 0.48 0.26 25.00
117 INT54972 Binding of EDNRA and EDNRB 7 0.52 3.31 0.97 23.56
118 INT278824 Positive_regulation of Binding of EDNRA and EDNRB 1 0.12 1.65 0.53 23.56
119 INT278819 EDNRA Negative_regulation of Binding of EDNRA and EDNRB 1 0.04 1.65 0.53 23.56
120 INT278820 EDNRA Negative_regulation of Binding of EDN1 and EDNRB 1 0.03 1.1 0.35 23.56
121 INT278817 EDNRA Negative_regulation of Binding of EDN1 and EDNRA 1 0.02 0.55 0.18 23.56
122 INT278818 EDNRA Negative_regulation of Binding of EDNRB and EDNRB 1 0.06 0.55 0.18 23.56
123 INT278827 Binding of EDN1 and EDNRB 3 0.17 2.7 0.67 23.40
124 INT278825 Positive_regulation of Binding of EDN1 and EDNRB 3 0.16 1.24 0.49 23.40
125 INT329317 ACE Regulation of Positive_regulation of KNG1 1 0.02 1.05 0.12 21.04
126 INT329325 ACE Regulation of Negative_regulation of Agtr2 1 0.01 0.93 0.12 21.04
127 INT208298 IGIP Positive_regulation of Stat3 1 0.09 0.48 0.09 18.64
128 INT178097 Binding of EDN1 and EDNRA 7 0.21 5.97 0.62 18.00
129 INT278828 Positive_regulation of Binding of EDN1 and EDNRA 1 0.06 0.51 0.15 18.00
130 INT269995 Positive_regulation of Binding of Nfkb2 and Tpx2 1 0.05 0.51 0.21 17.92
131 INT208300 IGIP Positive_regulation of Stat1 1 0.07 0.42 0.09 17.76
132 INT269994 Binding of Nfkb2 and Tpx2 1 0.04 0.51 0.21 17.32
133 INT329324 KNG1 Positive_regulation of Localization of ecs 1 0.00 1.16 0.17 17.20
134 INT263081 IFN1@ Regulation of CXCL10 1 0.07 0.15 0.15 16.60
135 INT331626 Edn1 Positive_regulation of Itk 1 0.00 0.57 0.07 11.08
136 INT269315 Binding of Crp and Gp6 1 0.03 0 0 10.48
137 INT266406 Binding of APP and Ager 1 0.00 2.34 1.57 8.48
138 INT285205 Binding of VEGFA and SLEB1 1 0.05 5.12 0.38 7.60
139 INT149117 Binding of CD80 and CTLA4 31 0.52 12.7 7.73 5.00
140 INT155484 Binding of CD86 and CTLA4 15 0.52 8.85 6.09 5.00
141 INT176477 Binding of CXCR3 and CXCL10 14 0.25 10.61 5.87 5.00
142 INT101942 Binding of CD40 and CD40LG 16 0.23 15.24 4.01 5.00
143 INT194647 Binding of CD28 and CD80 15 0.40 4.9 3.22 5.00
144 INT130721 Binding of IL1B and IL1RN 6 0.05 5.29 2.85 5.00
145 INT175329 Binding of ICAM1 and ITGAL 14 0.18 10.06 2.81 5.00
146 INT115367 Binding of IL6 and IL6R 12 0.07 8.16 2.36 5.00
147 INT194646 Binding of CD28 and CD86 7 0.40 2.69 2.21 5.00
148 INT243043 Binding of Mmp9 and Timp1 1 0.05 0.25 1.86 5.00
149 INT266391 Binding of Ager and S100a1 1 0.01 5.63 1.69 5.00
150 INT215096 Binding of Hmgb1 and Tlr2 9 0.38 11.61 1.61 5.00
151 INT222185 Binding of Ccr1 and Ccl3 4 0.23 2.7 1.47 5.00
152 INT285569 TNF Negative_regulation of Gene_expression of Il6 1 0.03 2.83 1.46 5.00
153 INT186355 Il23a Positive_regulation of Gene_expression of Il17a 4 0.12 3 1.24 5.00
154 INT290667 Il6 Positive_regulation of Stat3 3 0.69 2.42 1.15 5.00
155 INT173059 Binding of KDR and VEGFA 43 0.43 29.63 1.1 5.00
156 INT176474 Binding of CXCR3 and CXCL9 3 0.22 1.9 1.05 5.00
157 INT225158 Binding of CDK2 and CDKN1A 7 0.30 3.26 1.02 5.00
158 INT285561 Il23a Positive_regulation of Gene_expression of Il22 2 0.06 2.45 0.93 5.00
159 INT226337 Binding of IL10 and IL10RA 2 0.24 2.51 0.85 5.00
160 INT187290 Binding of HEY1 and Gtf3a 1 0.00 6.18 0.83 5.00
161 INT182814 Binding of ICAM1 and PECAM1 2 0.02 3.32 0.77 5.00
162 INT183698 Binding of Cxcr2 and Cxcl1 3 0.33 3.26 0.76 5.00
163 INT266408 Binding of HMGB1 and Ager 1 0.01 2.57 0.76 5.00
164 INT170127 Binding of ITGAL and PECAM1 2 0.01 2.71 0.75 5.00
165 INT316673 Binding of CALR and LRP1 1 0.39 1.89 0.74 5.00
166 INT104835 IRF6 Positive_regulation of IL10 4 0.32 0.91 0.69 5.00
167 INT167505 Binding of CXCR3 and CXCL11 2 0.26 0.86 0.67 5.00
168 INT285562 Binding of Il27ra and Il27 1 0.10 2.19 0.67 5.00
169 INT285943 IL17A Positive_regulation of Localization of IL6 3 0.20 2.02 0.65 5.00
170 INT254199 Il10 Positive_regulation of Gene_expression of Socs3 2 0.06 0.75 0.63 5.00
171 INT181084 Binding of S100a8 and S100a9 6 0.42 2.91 0.62 5.00
172 INT182819 Binding of CD63 and PECAM1 1 0.00 1.63 0.61 5.00
173 INT182815 Binding of CD63 and ICAM1 1 0.00 1.63 0.61 5.00
174 INT285467 Negative_regulation of Binding of IL1B and IL1RN 1 0.05 1.33 0.61 5.00
175 INT345180 Binding of Lpar4 and Gpr87 1 0.06 0.69 0.59 5.00
176 INT316674 Binding of CRP and SFTPD 1 0.16 2.02 0.59 5.00
177 INT345192 Binding of Gpr87 and Lpar5 1 0.07 0.69 0.59 5.00
178 INT244232 Binding of Ccr5 and Ccl4 3 0.17 1.48 0.55 5.00
179 INT266381 Positive_regulation of Ager Positive_regulation of Nfkb1 1 0.00 0.77 0.55 5.00
180 INT266376 Binding of Ager and Itgam 1 0.00 2.31 0.54 5.00
181 INT339532 FGF2 Positive_regulation of YWHAZ 1 0.00 1.26 0.54 5.00
182 INT285940 Binding of IL6 and IL17A 1 0.11 1.42 0.53 5.00
183 INT182813 EEF1A2 Negative_regulation of ITGAL 1 0.10 1.53 0.51 5.00
184 INT254125 Binding of Bcl2a1a and Tlr4 Positive_regulation of Localization of Il6 1 0.00 1.23 0.5 5.00
185 INT230532 LILRB1 Positive_regulation of Gene_expression of Mmp2 1 0.14 1.04 0.5 5.00
186 INT230533 LILRB1 Positive_regulation of Positive_regulation of Mmp9 1 0.20 1.03 0.5 5.00
187 INT254119 Binding of Bcl2a1a and Tlr4 1 0.01 1.34 0.49 5.00
188 INT260858 IL6 Positive_regulation of Gene_expression of VEGFA 2 0.31 1.77 0.48 5.00
189 INT264136 IFNA1 Positive_regulation of Socs3 1 0.01 0.38 0.46 5.00
190 INT264137 IFNA1 Positive_regulation of Socs1 1 0.01 0.38 0.46 5.00
191 INT290671 Binding of Socs3 and Stat3 2 0.23 1.59 0.45 5.00
192 INT254120 Aliq1 Positive_regulation of Tbce 1 0.00 0.68 0.43 5.00
193 INT230437 Binding of PDX1 and HRCT1 1 0.04 2.45 0.43 5.00
194 INT231225 Binding of C1S and SFTPC 1 0.39 1.51 0.43 5.00
195 INT264135 Socs1 Positive_regulation of Protein_catabolism of TOLLIP 1 0.00 0.33 0.41 5.00
196 INT300652 Ephb6 Regulation of Gene_expression of Cxcl10 1 0.01 0.59 0.41 5.00
197 INT285560 Il23a Positive_regulation of Il17a 1 0.09 1.45 0.39 5.00
198 INT285571 Binding of IL8 and Il17a 1 0.04 1.03 0.38 5.00
199 INT266419 HMGB1 Positive_regulation of Ager 1 0.01 1.37 0.37 5.00
200 INT335457 Binding of SRA1 and hb 1 0.00 1.83 0.37 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Pulmonary Fibrosis. They are ordered first by their pain relevance and then by number of times they were reported in Pulmonary Fibrosis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT171060 Gene_expression of PDX1 72 0.75 72.57 17.97 100.00
2 INT37541 Gene_expression of SPP1 113 0.77 68.54 11.35 100.00
3 INT149138 Binding of PDX1 27 0.37 32.62 9.33 100.00
4 INT88935 Positive_regulation of SPP1 36 0.70 31.07 5.49 100.00
5 INT171059 Localization of PDX1 8 0.56 6.7 1.9 100.00
6 INT102233 Gene_expression of MMP7 40 0.76 15.78 2.93 100.00
7 INT54435 Binding of Sptan1 8 0.36 4.7 2.44 100.00
8 INT133269 Positive_regulation of PDX1 10 0.54 9.77 1.9 100.00
9 INT11361 Gene_expression of SERPINE1 183 0.78 136.45 27.97 100.00
10 INT88934 Regulation of SPP1 9 0.54 6.94 1.47 100.00
11 INT86521 Gene_expression of Lpar1 167 0.78 154.61 80.35 100.00
12 INT133214 Regulation of PDX1 9 0.34 10.26 3.36 100.00
13 INT47702 Gene_expression of Sptan1 24 0.76 7.6 11.36 100.00
14 INT11635 Positive_regulation of Gene_expression of SERPINE1 35 0.68 24.57 4.26 100.00
15 INT36336 Gene_expression of Tgfb1 41 0.77 21.82 14.53 100.00
16 INT185837 Regulation of Gene_expression of MMP7 6 0.44 2.87 0.92 100.00
17 INT142419 Regulation of Sptan1 2 0.38 2.52 0.55 100.00
18 INT47950 Negative_regulation of ELOVL1 15 0.41 20.33 1.41 100.00
19 INT171058 Negative_regulation of PDX1 5 0.32 9.31 2.72 100.00
20 INT185840 Positive_regulation of Localization of PDX1 2 0.27 0.78 0.33 100.00
21 INT52755 Positive_regulation of Sptan1 6 0.67 1.57 3.82 100.00
22 INT332230 Regulation of Pdx1 1 0.01 0.99 0.25 100.00
23 INT200552 Regulation of Aliq1 3 0.08 7.55 1.42 100.00
24 INT161102 Regulation of MMP7 4 0.37 6.79 0.37 100.00
25 INT88933 Regulation of Gene_expression of SPP1 7 0.45 6.05 0.59 100.00
26 INT213215 Gene_expression of SS18L1 2 0.58 3.71 0.29 100.00
27 INT153277 Gene_expression of Lpar6 2 0.49 1.76 0.61 100.00
28 INT213217 Negative_regulation of Binding of PAH 2 0.32 2.03 0.19 100.00
29 INT9110 Binding of PAH 32 0.41 42.1 3.1 99.98
30 INT60695 Positive_regulation of Gene_expression of Il10 154 0.70 120.28 43.07 99.96
31 INT74681 Positive_regulation of Gene_expression of Mmp2 23 0.55 15.58 10.74 99.96
32 INT85147 Positive_regulation of Gene_expression of Tgfb1 12 0.46 7.29 3.24 99.96
33 INT185835 Negative_regulation of Gene_expression of MMP7 4 0.35 2.35 0.46 99.96
34 INT185826 Negative_regulation of Gene_expression of SPP1 1 0.42 0.8 0.23 99.96
35 INT91430 Positive_regulation of CD44 25 0.69 15.43 1.76 99.96
36 INT91431 Positive_regulation of Gene_expression of CD44 18 0.69 9.25 1.12 99.96
37 INT63361 Gene_expression of CD44 126 0.77 71.58 12.96 99.96
38 INT153794 Gene_expression of Ctsk 51 0.77 24.99 7.28 99.92
39 INT180922 Negative_regulation of Mmp8 4 0.43 8.35 3.72 99.92
40 INT192349 Negative_regulation of Gene_expression of PDGFB 5 0.31 2.64 1.25 99.92
41 INT133311 Binding of SPP1 10 0.37 9.47 1.65 99.90
42 INT185839 Binding of MMP7 3 0.36 1.29 0.33 99.90
43 INT72370 Gene_expression of Timp1 82 0.65 57.52 24.16 99.88
44 INT2431 Positive_regulation of Mpo 275 0.70 211.99 78.47 99.88
45 INT153913 Positive_regulation of Lpar1 31 0.70 33.5 16.14 99.88
46 INT158459 Negative_regulation of Gene_expression of Timp1 8 0.40 4.21 2.16 99.88
47 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 99.86
48 INT97128 Localization of SPP1 32 0.80 21.75 4.02 99.84
49 INT97331 Positive_regulation of Timp1 20 0.45 13.32 8.57 99.84
50 INT39565 Gene_expression of Ptger2 424 0.75 229.28 72.68 99.84
51 INT185830 Positive_regulation of Localization of SPP1 2 0.50 3.39 0.33 99.84
52 INT224366 Gene_expression of Ager 111 0.77 125.37 8.49 99.78
53 INT224368 Negative_regulation of Gene_expression of Ager 8 0.39 13.94 1.03 99.78
54 INT166131 Positive_regulation of Positive_regulation of Col7a1 8 0.46 6.4 1.65 99.76
55 INT70897 Positive_regulation of Gene_expression of PDGFB 15 0.57 13.04 3.52 99.72
56 INT103924 Positive_regulation of Akt1 359 0.69 158.94 60.34 99.72
57 INT175685 Positive_regulation of Gene_expression of Timp1 11 0.57 8.18 2.58 99.70
58 INT74682 Positive_regulation of Mmp2 72 0.69 40.46 21.73 99.68
59 INT156137 Gene_expression of Col1a2 28 0.73 13.3 3.99 99.68
60 INT104250 Positive_regulation of Gene_expression of SPP1 17 0.69 13.22 1.44 99.64
61 INT100939 Gene_expression of Il13 176 0.73 125.1 43.38 99.62
62 INT65260 Positive_regulation of Col7a1 95 0.69 61.73 18.42 99.62
63 INT172963 Negative_regulation of Pdgfa 11 0.21 12.94 2.64 99.62
64 INT181986 Negative_regulation of Positive_regulation of Col7a1 6 0.08 7.4 2.46 99.62
65 INT16721 Negative_regulation of Cat 56 0.59 44.44 22.84 99.60
66 INT80034 Positive_regulation of Gene_expression of FAS 32 0.67 30.34 8.51 99.60
67 INT204775 Regulation of Tlr2 21 0.41 13.6 2.18 99.60
68 INT70896 Gene_expression of PDGFB 48 0.65 33.55 8.39 99.56
69 INT257290 Negative_regulation of Transcription of COL1A1 3 0.27 1.64 0.13 99.54
70 INT96914 Phosphorylation of Mapk14 168 0.82 108.46 53.32 99.52
71 INT8243 Positive_regulation of Il6 451 0.70 358.24 119.28 99.50
72 INT10162 Positive_regulation of Gpx3 10 0.40 3.37 3.68 99.50
73 INT92684 Positive_regulation of Col3a1 5 0.56 1.79 0.45 99.50
74 INT120509 Gene_expression of Cat 65 0.77 50.9 9.75 99.48
75 INT68973 Positive_regulation of Mmp9 89 0.52 58.56 30.04 99.48
76 INT19185 Negative_regulation of Cd4 80 0.51 61.32 8.51 99.48
77 INT96778 Positive_regulation of Pdgfa 22 0.46 12.7 5.31 99.44
78 INT223080 Binding of Pdgfa 8 0.18 7.21 2.44 99.44
79 INT48202 Gene_expression of Tgfb1 146 0.78 89.93 27.76 99.44
80 INT223078 Negative_regulation of Gene_expression of Pdgfrb 4 0.35 3.64 0.25 99.44
81 INT61120 Positive_regulation of Gene_expression of Tgfb1 34 0.70 21.15 6.93 99.44
82 INT200554 Positive_regulation of Aliq1 29 0.22 33.02 5.32 99.44
83 INT21979 Negative_regulation of EDN1 52 0.58 24.65 12.55 99.42
84 INT100938 Positive_regulation of Il13 47 0.69 42.11 14.36 99.42
85 INT13186 Positive_regulation of Il4 113 0.68 71.22 31.4 99.42
86 INT266318 Negative_regulation of Negative_regulation of Ager 1 0.02 0.66 0.29 99.42
87 INT95116 Negative_regulation of PDGFA 24 0.57 19.56 1.29 99.38
88 INT8905 Gene_expression of EDN1 215 0.78 157.1 34.19 99.36
89 INT53704 Negative_regulation of Col7a1 42 0.35 22.4 6.88 99.36
90 INT8904 Positive_regulation of Gene_expression of EDN1 66 0.70 65.4 14.42 99.36
91 INT70614 Gene_expression of FAS 118 0.75 112.33 19.01 99.36
92 INT83590 Positive_regulation of Gene_expression of Col6a6 2 0.03 1.82 1.12 99.34
93 INT224367 Negative_regulation of Ager 15 0.46 25.57 0.78 99.32
94 INT96937 Gene_expression of Mmp9 191 0.75 150.3 56.01 99.28
95 INT113606 Positive_regulation of Gene_expression of Mmp9 46 0.64 44 15.07 99.28
96 INT3760 Positive_regulation of ALB 142 0.70 87.46 26.7 99.28
97 INT147486 Negative_regulation of Positive_regulation of Rock2 1 0.06 1.67 0.24 99.28
98 INT96116 Transcription of COL1A1 10 0.44 4.57 1.81 99.26
99 INT221041 Binding of CCL18 3 0.47 2.08 0.59 99.26
100 INT185825 Localization of MMP7 10 0.78 2.85 1.11 99.20
101 INT201810 Gene_expression of LEFTY2 6 0.56 3.94 1.74 99.20
102 INT231393 Positive_regulation of Gene_expression of LEFTY2 1 0.03 1.09 0.47 99.20
103 INT185820 Positive_regulation of Localization of MMP7 1 0.41 0.72 0.33 99.20
104 INT114874 Gene_expression of Stat3 78 0.76 53.99 9.49 99.20
105 INT2378 Negative_regulation of SERPINE1 47 0.59 34.55 9.9 99.18
106 INT60694 Gene_expression of Il10 567 0.78 369.48 143.69 99.16
107 INT71769 Negative_regulation of Gene_expression of Il10 40 0.57 22.53 10.37 99.16
108 INT250768 Phosphorylation of Cxcl2 1 0.16 0.46 0.23 99.14
109 INT6231 Gene_expression of Col6a6 5 0.26 2.56 1.78 99.14
110 INT1759 Gene_expression of TIMP1 267 0.77 133.87 59.29 99.12
111 INT8629 Positive_regulation of COL7A1 72 0.69 40.66 12.09 99.12
112 INT178108 Positive_regulation of MMP7 11 0.56 7.31 2.85 99.12
113 INT89309 Negative_regulation of Pde4b 21 0.53 12.81 7.32 99.12
114 INT185834 Positive_regulation of Positive_regulation of MMP7 1 0.33 0.66 0.3 99.12
115 INT266893 Negative_regulation of Gene_expression of Cat 4 0.58 3.76 0.55 99.08
116 INT11313 Positive_regulation of Il6 526 0.70 331.27 201.59 99.08
117 INT179654 Positive_regulation of Eln 5 0.44 4.3 0.43 99.08
118 INT112648 Positive_regulation of Fn1 19 0.49 13.73 1.66 99.08
119 INT92678 Positive_regulation of Ecm1 30 0.09 28.41 3.68 99.08
120 INT188223 Positive_regulation of Gene_expression of EBI3 2 0.07 0.95 0.63 99.06
121 INT60710 Gene_expression of Col7a1 217 0.78 113.2 35.2 99.04
122 INT42378 Positive_regulation of Socs3 21 0.67 15.81 5.71 99.04
123 INT134966 Localization of Col7a1 23 0.42 16.4 5.24 99.04
124 INT48203 Positive_regulation of Tgfb1 67 0.70 41.31 11.07 99.04
125 INT180921 Protein_catabolism of Mmp7 1 0.47 0.96 0.39 99.04
126 INT9130 Negative_regulation of TGFB1 16 0.41 12.21 2.92 99.02
127 INT224620 Positive_regulation of Gene_expression of Ctsk 13 0.68 8.35 2.21 99.00
128 INT165915 Regulation of Negative_regulation of Pde4a 5 0.29 6.72 2.91 99.00
129 INT138915 Gene_expression of Stat1 144 0.77 69.53 5.85 98.98
130 INT245262 Negative_regulation of Gene_expression of Stat1 9 0.42 2.87 0.42 98.98
131 INT30169 Negative_regulation of Pde4a 107 0.58 81 36.23 98.96
132 INT208270 Binding of Tagln 1 0.16 0.63 0.08 98.96
133 INT187817 Regulation of Gene_expression of Il13 6 0.22 6.5 2.92 98.94
134 INT186270 Regulation of Il13 13 0.43 11.58 4.19 98.94
135 INT79693 Regulation of Il4 30 0.51 21.96 8.6 98.94
136 INT120901 Positive_regulation of Gene_expression of Il13 36 0.57 31.63 13.36 98.94
137 INT71768 Regulation of Gene_expression of Il10 27 0.62 19.17 10.4 98.92
138 INT91173 Gene_expression of Pdgfrb 33 0.65 32.55 3.09 98.92
139 INT79835 Regulation of Il10 28 0.61 21.22 11.29 98.80
140 INT14733 Positive_regulation of Gene_expression of TGFB1 71 0.69 49.89 22.2 98.80
141 INT95207 Negative_regulation of Pde5a 46 0.58 32.01 10.14 98.80
142 INT99555 Gene_expression of EBI3 3 0.09 2.6 0.9 98.80
143 INT139664 Gene_expression of CCL18 83 0.76 37.05 21.95 98.78
144 INT221045 Positive_regulation of Gene_expression of CCL18 17 0.67 5.27 3.54 98.78
145 INT66227 Gene_expression of COX18 41 0.50 26.91 6.26 98.78
146 INT110020 Gene_expression of Mapk14 142 0.77 72.33 30.08 98.76
147 INT79722 Regulation of Cat 14 0.62 5.88 2.86 98.76
148 INT57162 Positive_regulation of Gene_expression of CDKN1A 64 0.68 35.3 9.69 98.74
149 INT66423 Binding of ELOVL1 52 0.40 61.63 5.16 98.72
150 INT80036 Positive_regulation of FAS 42 0.67 42.22 9.4 98.68
151 INT59449 Negative_regulation of Timp1 76 0.42 54.86 26.99 98.68
152 INT81049 Positive_regulation of CASP1 44 0.67 19.97 5.69 98.68
153 INT11560 Positive_regulation of CASP3 236 0.70 184.33 39.38 98.68
154 INT59870 Gene_expression of F3 51 0.65 51.83 14.01 98.68
155 INT69723 Gene_expression of SERPINB2 7 0.60 4.54 1.28 98.68
156 INT228870 Negative_regulation of Lpar1 17 0.51 20.97 8.77 98.64
157 INT120072 Gene_expression of Smad7 38 0.74 20.87 3.69 98.62
158 INT120076 Positive_regulation of Gene_expression of Smad7 16 0.65 11.33 1.25 98.62
159 INT146553 Positive_regulation of Rock2 4 0.44 2.56 1.09 98.62
160 INT20374 Gene_expression of Il4 515 0.76 306.15 114.12 98.60
161 INT105777 Gene_expression of Pde4a 30 0.76 12.67 8.52 98.60
162 INT83953 Gene_expression of Cxcl2 140 0.75 113.07 43.65 98.58
163 INT21582 Regulation of Gene_expression of TIMP1 20 0.61 12.39 4.77 98.56
164 INT170854 Gene_expression of CFD 26 0.68 39.77 4.74 98.56
165 INT28215 Gene_expression of CDKN1A 196 0.76 113.9 18.3 98.54
166 INT56291 Gene_expression of Ros1 503 0.63 274.12 81.5 98.52
167 INT9656 Regulation of Gene_expression of Il6 57 0.62 33.3 17.71 98.52
168 INT208381 Positive_regulation of Gene_expression of Uvrag 1 0.01 1.01 0.4 98.48
169 INT208382 Gene_expression of Uvrag 1 0.02 1.01 0.4 98.48
170 INT146808 Positive_regulation of CCL18 25 0.69 11.98 5.71 98.48
171 INT50855 Gene_expression of TRIM21 4 0.65 3.07 0.71 98.48
172 INT8662 Positive_regulation of EDN1 144 0.70 125.34 19.59 98.44
173 INT122902 Positive_regulation of Gene_expression of Spp1 54 0.70 56.3 6.33 98.44
174 INT123885 Positive_regulation of Lgals3 23 0.57 24.38 6.32 98.44
175 INT48408 Gene_expression of ICAM1 494 0.78 340.08 88.6 98.42
176 INT96068 Positive_regulation of Timp1 30 0.58 23.94 8.17 98.40
177 INT111398 Localization of Mmp2 37 0.76 23.78 7.17 98.40
178 INT118492 Regulation of Pde4a 7 0.61 6.32 6.04 98.36
179 INT125980 Binding of CFD 8 0.42 10.96 1.39 98.32
180 INT102825 Regulation of Timp1 10 0.38 5.49 1.79 98.32
181 INT80033 Binding of FAS 37 0.48 41.19 5.67 98.28
182 INT48198 Binding of Tgfb1 29 0.47 19.59 2.46 98.20
183 INT14740 Gene_expression of TGFB1 272 0.78 168.48 60.18 98.14
184 INT138922 Positive_regulation of Stat1 57 0.69 28.35 7.2 98.12
185 INT159989 Positive_regulation of Ctsk 17 0.69 10.51 2.25 98.08
186 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 98.08
187 INT100821 Localization of Ros1 59 0.60 45.26 11.92 98.04
188 INT104388 Positive_regulation of Gene_expression of Cxcl2 31 0.66 25.68 7.49 98.00
189 INT192350 Negative_regulation of UBR7 1 0.01 0.36 0.21 98.00
190 INT115384 Positive_regulation of Mmp9 121 0.68 94.74 43.02 97.96
191 INT132997 Localization of Mmp9 59 0.80 45.9 17.61 97.88
192 INT22939 Gene_expression of Csf2 164 0.78 85.1 32.22 97.88
193 INT186463 Negative_regulation of Gene_expression of SFTPC 2 0.42 4.52 0.75 97.88
194 INT23653 Binding of Egf 22 0.36 11.34 4.12 97.84
195 INT12892 Negative_regulation of TIMP1 136 0.58 83.13 36.54 97.84
196 INT29503 Gene_expression of Mmp2 95 0.77 56.92 31.68 97.76
197 INT88544 Gene_expression of MMRN1 102 0.75 68.8 14.55 97.76
198 INT173509 Positive_regulation of Localization of Timp1 5 0.41 2.99 2.04 97.76
199 INT180920 Positive_regulation of Positive_regulation of Timp1 2 0.38 1.59 0.46 97.76
200 INT111397 Localization of Timp1 17 0.70 11.67 8.76 97.76
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