D:Pyoderma Gangrenosum

From wiki-pain
Jump to: navigation, search

pChart

Disease Term
Synonyms None
Documents 181
Hot Single Events 31
Hot Interactions 4

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Pyoderma Gangrenosum. They are ordered first by their relevance to Pyoderma Gangrenosum and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT150392 Binding of MEFV and PSTPIP1 2 0.51 10.49 1.44 98.32
2 INT317834 Binding of Pstpip1 and Il1 1 0.00 2.03 0.48 91.60
3 INT278379 Binding of Pstpip1 and Mefv 3 0.03 2.02 0.48 91.60
4 INT317832 Binding of Mefv and Il1 1 0.03 3.89 0.7 87.04
5 INT197051 Binding of HLA-E and ATP8A1 1 0.00 6.52 1.14 77.52
6 INT274569 Binding of PSTPIP2 and PSTPIP1 1 0.50 2.07 0.31 64.56
7 INT274584 Binding of PSTPIP1 and PYCARD 1 0.13 1.34 0.22 62.60
8 INT274578 Binding of ABL1 and PSTPIP1 1 0.07 1.55 0.21 58.36
9 INT274583 Binding of ABL1 and PSTPIP2 1 0.06 0.79 0.11 57.68
10 INT342886 Binding of C3 and CD40 1 0.02 0.66 0.05 39.04
11 INT342887 Binding of IFNG and IFNGR1 1 0.02 0.65 0.05 34.36
12 INT150393 Binding of CASP1 and MEFV 2 0.16 2.48 0.45 32.96
13 INT334879 CASP1 Regulation of IL1B 1 0.03 1.63 0.31 31.76
14 INT197050 Binding of HLA-DOA and HLA-E 2 0.08 1.73 0.58 16.56
15 INT317836 Binding of Fibp and Pycard 1 0.00 2.68 0.98 5.00
16 INT150391 Binding of MEFV and PYCARD 4 0.14 3 0.48 5.00
17 INT317835 Nlrp3 Positive_regulation of Il18 1 0.08 1.49 0.31 5.00
18 INT317833 Nlrp3 Positive_regulation of Localization of Il1 1 0.06 1.38 0.26 5.00
19 INT277995 TNF Positive_regulation of Gene_expression of Tnfrsf1a 1 0.03 1.48 0.22 5.00
20 INT277996 TNF Positive_regulation of Tnfrsf1a 1 0.03 1.48 0.22 5.00
21 INT317831 Binding of Mefv and Nlrx1 1 0.00 1.77 0.2 5.00
22 INT274568 Binding of MEFV and PSTPIP2 1 0.45 0.61 0.13 5.00
23 INT274553 MEFV Positive_regulation of Binding of PSTPIP1 and PYCARD 1 0.13 0.19 0.05 5.00
24 INT274574 MEFV Regulation of Localization of PSTPIP1 1 0.48 0.17 0.04 5.00
25 INT274567 Positive_regulation of Binding of MEFV and PSTPIP1 1 0.46 0.22 0.04 5.00
26 INT274587 Binding of PSTPIP1 and BFAR 1 0.17 0.08 0.04 5.00
27 INT274585 Binding of PSTPIP1 and TRIP10 1 0.15 0.08 0.04 5.00
28 INT274577 Binding of MEFV and SASH3 1 0.01 0.45 0.04 5.00
29 INT274589 Binding of MEFV and Regulation of Localization of PSTPIP1 1 0.48 0.17 0.04 5.00
30 INT274588 Binding of PSTPIP1 and Positive_regulation of MEFV 1 0.46 0.05 0.03 5.00
31 INT274573 Positive_regulation of Binding of MEFV and PYCARD 1 0.09 0.06 0.03 5.00
32 INT274575 MEFV Regulation of PSTPIP1 1 0.42 0.2 0.03 5.00
33 INT274552 PSTPIP1 Positive_regulation of Binding of PSTPIP1 and PYCARD 1 0.13 0.06 0.03 5.00
34 INT274591 Binding of PSTPIP1 and SASH3 1 0.01 0 0 5.00
35 INT344266 Binding of APOH and CD40LG 1 0.04 0.31 0 5.00
36 INT274623 Binding of TRIP10 and Amph 1 0.17 0 0 5.00
37 INT274586 Binding of TRIP10 and BFAR 1 0.06 0 0 5.00
38 INT274570 Binding of MEFV and Regulation of BFAR 1 0.09 0.05 0 5.00
39 INT274576 MEFV Positive_regulation of PSTPIP1 1 0.46 0 0 5.00
40 INT274590 Positive_regulation of Binding of MEFV and SASH3 1 0.01 0.27 0 5.00
41 INT274622 Binding of CLIP1 and Amph 1 0.40 0 0 5.00
42 INT274581 Binding of CLIP1 and BFAR 1 0.15 0 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Pyoderma Gangrenosum. They are ordered first by their pain relevance and then by number of times they were reported in Pyoderma Gangrenosum. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT17326 Binding of Plg 14 0.43 11.72 1.94 100.00
2 INT16478 Positive_regulation of Plg 29 0.45 18.07 4.07 100.00
3 INT16389 Gene_expression of Plg 80 0.67 36.88 6.74 100.00
4 INT105571 Gene_expression of SRGN 33 0.58 14.68 1.19 100.00
5 INT49286 Binding of IFNK 2 0.25 2.48 0.34 99.98
6 INT14149 Binding of C6orf25 11 0.48 9.04 1.71 99.98
7 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 99.84
8 INT10837 Positive_regulation of Gene_expression of IL8 294 0.70 190.08 70.34 99.84
9 INT24978 Binding of SFTPA1 22 0.47 15.09 7.76 99.62
10 INT5650 Gene_expression of Mpo 117 0.77 80.27 26.42 98.72
11 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 98.24
12 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 95.84
13 INT764 Gene_expression of OLAH 25 0.67 25.58 8.07 94.72
14 INT12163 Positive_regulation of OLAH 8 0.68 6.91 1.67 94.28
15 INT19775 Localization of Il1 183 0.78 145.5 50.91 94.00
16 INT3512 Gene_expression of Igha 9 0.60 7.71 1.13 93.44
17 INT1941 Binding of PSTPIP1 36 0.48 5.92 1.16 91.64
18 INT159248 Positive_regulation of Binding of MEFV 2 0.46 2.54 0.2 91.32
19 INT6478 Negative_regulation of Binding of TNF 36 0.58 30.42 13.31 91.16
20 INT150395 Binding of MEFV 55 0.44 31.18 3.42 91.00
21 INT6481 Binding of TNF 624 0.48 510.2 214.82 86.64
22 INT274612 Phosphorylation of KPTN 1 0.02 1.25 0.18 85.36
23 INT6852 Localization of TNF 883 0.81 705.95 270.84 84.88
24 INT15514 Negative_regulation of Crp 275 0.59 194.6 64.86 83.48
25 INT38056 Localization of Crp 71 0.78 53.14 17.03 83.48
26 INT62400 Positive_regulation of Localization of Il1 34 0.67 35.53 7.96 82.40
27 INT12720 Positive_regulation of Il1 246 0.70 195.97 72.05 82.08
28 INT15982 Positive_regulation of NLRP3 25 0.65 23.19 3.57 81.68
29 INT149669 Positive_regulation of MEFV 12 0.46 14.17 2.07 81.68
30 INT52899 Positive_regulation of TNFRSF1A 16 0.46 19.04 3.34 81.68
31 INT222205 Positive_regulation of PSTPIP1 8 0.69 4.69 0.62 81.68
32 INT126719 Gene_expression of EBVS1 1 0.01 1.34 0.07 79.20
33 INT173508 Negative_regulation of Fgfr1 4 0.55 5.08 0.66 77.60
34 INT11699 Binding of HLA-E 85 0.47 52.51 13.41 77.52
35 INT274601 Regulation of PSTPIP1 3 0.45 3.76 0.28 76.52
36 INT9408 Positive_regulation of Crp 296 0.69 242.27 57.35 75.00
37 INT756 Gene_expression of C3 138 0.75 100.6 19.2 75.00
38 INT4137 Positive_regulation of C3 73 0.69 48.57 12.63 75.00
39 INT20129 Regulation of Il1 53 0.53 44.14 19.89 70.52
40 INT749 Gene_expression of HLA-B 341 0.75 224.12 77.37 68.80
41 INT284359 Negative_regulation of Mvk 4 0.37 6.62 0.99 68.32
42 INT317823 Positive_regulation of Negative_regulation of Mvk 2 0.30 3.33 0.62 68.32
43 INT284362 Positive_regulation of Mvk 3 0.44 3.32 0.46 68.32
44 INT174653 Localization of MEFV 15 0.70 12.06 1.93 63.32
45 INT274621 Localization of PSTPIP1 1 0.80 1.48 0.13 62.92
46 INT56985 Gene_expression of MEFV 56 0.71 46.71 9.47 61.36
47 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 50.00
48 INT118054 Regulation of ARMC9 23 0.34 11.32 1.06 49.64
49 INT19472 Gene_expression of Il1 554 0.76 419.75 175.35 45.44
50 INT80755 Gene_expression of CD40 88 0.75 53.68 17.86 40.28
51 INT5056 Gene_expression of IFNG 216 0.78 137.52 74.57 34.92
52 INT61619 Gene_expression of IL12A 194 0.77 146.07 41.97 34.92
53 INT342889 Gene_expression of IFNGR1 1 0.28 0.65 0.05 34.92
54 INT11380 Negative_regulation of IL1B 215 0.59 125.62 72.35 23.40
55 INT6484 Binding of IL1B 122 0.47 75.84 35.07 15.80
56 INT25607 Binding of Il1 82 0.47 64.4 23.9 15.24
57 INT9236 Regulation of Gene_expression of TNF 204 0.62 162.66 72.99 14.96
58 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 7.92
59 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
60 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
61 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 5.00
62 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 5.00
63 INT9660 Regulation of TNF 363 0.62 312.94 139.99 5.00
64 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61 5.00
65 INT20374 Gene_expression of Il4 515 0.76 306.15 114.12 5.00
66 INT118381 Gene_expression of Il17a 405 0.76 306.97 112.06 5.00
67 INT11381 Positive_regulation of IL1B 330 0.70 209.31 100.9 5.00
68 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 5.00
69 INT48408 Gene_expression of ICAM1 494 0.78 340.08 88.6 5.00
70 INT11937 Localization of Il6 228 0.81 139.83 64.39 5.00
71 INT48901 Negative_regulation of IL6 186 0.57 136.33 57.87 5.00
72 INT20375 Gene_expression of Hand1 213 0.60 148.51 54.53 5.00
73 INT22112 Positive_regulation of Localization of TNF 164 0.70 115.66 52.18 5.00
74 INT20382 Gene_expression of Hand2 211 0.66 142.26 51.05 5.00
75 INT6473 Positive_regulation of Gene_expression of IL1B 204 0.70 117.23 50.86 5.00
76 INT4216 Gene_expression of CD40LG 328 0.78 256.02 44.23 5.00
77 INT4004 Gene_expression of IGHG3 321 0.71 221.03 42.33 5.00
78 INT173693 Localization of Gopc 249 0.65 70.49 38.81 5.00
79 INT62827 Positive_regulation of ICAM1 184 0.70 180.95 36.28 5.00
80 INT60710 Gene_expression of Col7a1 217 0.78 113.2 35.2 5.00
81 INT20380 Gene_expression of Il5 172 0.78 104.75 34.78 5.00
82 INT6105 Positive_regulation of IL2 133 0.69 82.76 34.67 5.00
83 INT11325 Gene_expression of HLA-E 209 0.76 98.05 33.72 5.00
84 INT62830 Gene_expression of VCAM1 149 0.78 125.23 32.4 5.00
85 INT17886 Negative_regulation of Il1 95 0.57 70.91 31.25 5.00
86 INT56809 Binding of Tlr4 184 0.48 106.02 31.18 5.00
87 INT90792 Localization of Il10 144 0.80 87.88 30.03 5.00
88 INT9296 Negative_regulation of PLEK 100 0.57 36.65 27.52 5.00
89 INT703 Positive_regulation of Pth 177 0.70 127.09 27.26 5.00
90 INT14690 Localization of CSF2 124 0.80 85.17 27.26 5.00
91 INT19856 Gene_expression of CD8A 240 0.75 147.86 26.39 5.00
92 INT151758 Gene_expression of PYCARD 91 0.63 14.54 24.27 5.00
93 INT93738 Gene_expression of Tnfrsf1a 63 0.74 57.66 23.09 5.00
94 INT5055 Positive_regulation of IFNG 89 0.69 64.03 23.05 5.00
95 INT8483 Positive_regulation of Positive_regulation of TNF 73 0.67 60.35 22.03 5.00
96 INT11161 Gene_expression of HLA-DRB1 121 0.78 75.33 20.96 5.00
97 INT85952 Positive_regulation of AR 168 0.67 64.36 20.66 5.00
98 INT63340 Positive_regulation of Gene_expression of ICAM1 109 0.70 90.82 20.61 5.00
99 INT20379 Localization of Il4 85 0.73 51.22 20.55 5.00
100 INT78024 Gene_expression of ACLY 73 0.75 59.15 18.54 5.00
101 INT112017 Regulation of Hand2 77 0.36 62.23 18.04 5.00
102 INT19929 Negative_regulation of Positive_regulation of TNF 52 0.59 38.16 16.51 5.00
103 INT10214 Gene_expression of VIM 153 0.78 115.88 16.29 5.00
104 INT104045 Regulation of Hand1 65 0.35 51.32 16.26 5.00
105 INT22301 Positive_regulation of Gene_expression of CSF2 66 0.63 59.49 14.24 5.00
106 INT22276 Gene_expression of TBXA2R 65 0.77 23.22 14.21 5.00
107 INT59870 Gene_expression of F3 51 0.65 51.83 14.01 5.00
108 INT20378 Localization of Hand1 53 0.71 41.96 13.31 5.00
109 INT89404 Regulation of Negative_regulation of TNF 30 0.45 24.47 12.71 5.00
110 INT73829 Positive_regulation of Gene_expression of VCAM1 41 0.61 35.96 11.92 5.00
111 INT4047 Binding of F13A1 105 0.43 66.54 11.81 5.00
112 INT69035 Positive_regulation of Casp1 43 0.69 25.18 10.67 5.00
113 INT25608 Regulation of Gene_expression of Il1 37 0.44 27.76 10.1 5.00
114 INT61171 Gene_expression of S100A8 92 0.76 57.74 9.98 5.00
115 INT87193 Gene_expression of Tnfrsf1b 30 0.58 29.4 9.22 5.00
116 INT62829 Positive_regulation of VCAM1 39 0.70 38.42 9.15 5.00
117 INT69264 Gene_expression of KIT 207 0.78 179.41 8.95 5.00
118 INT6625 Negative_regulation of Pth 96 0.58 57.6 8.24 5.00
119 INT97516 Binding of PYCARD 46 0.36 7.06 7.85 5.00
120 INT19475 Positive_regulation of IL1A 20 0.67 17.99 7.57 5.00
121 INT17501 Negative_regulation of F2 70 0.58 32.23 7.51 5.00
122 INT103909 Gene_expression of NOD2 37 0.77 21.9 7.36 5.00
123 INT48626 Positive_regulation of Csf3 33 0.66 29.79 7.34 5.00
124 INT35584 Binding of ACLY 22 0.35 31.78 7.17 5.00
125 INT54662 Positive_regulation of Positive_regulation of Il1 21 0.43 19.33 7.14 5.00
126 INT181525 Localization of Il13 24 0.66 21.51 6.55 5.00
127 INT13406 Negative_regulation of CASP1 25 0.57 10.61 6.36 5.00
128 INT69985 Positive_regulation of Negative_regulation of TNF 21 0.50 13.26 6.31 5.00
129 INT90077 Gene_expression of Casp1 29 0.76 20.79 6.26 5.00
130 INT8683 Positive_regulation of F3 31 0.67 42.89 6.21 5.00
131 INT137052 Positive_regulation of PYCARD 30 0.43 4.72 6.17 5.00
132 INT91657 Negative_regulation of IL18 20 0.48 15.97 6.12 5.00
133 INT81049 Positive_regulation of CASP1 44 0.67 19.97 5.69 5.00
134 INT166765 Localization of PYCARD 21 0.70 3.89 5.66 5.00
135 INT114180 Negative_regulation of Il1rn 22 0.57 11.06 5.44 5.00
136 INT174688 Binding of Tlr2 45 0.42 36.65 5.25 5.00
137 INT6476 Gene_expression of TNFRSF1B 21 0.67 18.22 5.25 5.00
138 INT62525 Positive_regulation of SELE 38 0.70 46 5.25 5.00
139 INT28703 Negative_regulation of TFPI 29 0.38 19.81 4.93 5.00
140 INT12104 Positive_regulation of PLG 45 0.68 28.94 4.81 5.00
141 INT37661 Negative_regulation of SERPINC1 48 0.59 38.6 4.77 5.00
142 INT1901 Binding of Mefv 24 0.48 32.26 4.5 5.00
143 INT36221 Positive_regulation of Nlrp3 25 0.68 19.7 4.5 5.00
144 INT9842 Binding of F2 36 0.47 22.79 4.42 5.00
145 INT187836 Binding of Tnfrsf1a 19 0.46 18.08 4.33 5.00
146 INT20372 Localization of Il5 26 0.41 18.33 4.27 5.00
147 INT174195 Negative_regulation of HLA-E 31 0.42 11.98 3.88 5.00
148 INT99509 Gene_expression of CFLAR 25 0.75 22.59 3.78 5.00
149 INT16976 Negative_regulation of IL36RN 6 0.49 5.08 3.31 5.00
150 INT77670 Positive_regulation of ACLY 24 0.49 21.68 3.12 5.00
151 INT22277 Positive_regulation of Gene_expression of TBXA2R 13 0.69 5.95 2.92 5.00
152 INT84527 Positive_regulation of Gene_expression of F3 16 0.49 15.83 2.85 5.00
153 INT134375 Gene_expression of Cflar 14 0.58 8.4 2.66 5.00
154 INT94042 Positive_regulation of Gene_expression of S100A8 15 0.67 13.52 2.44 5.00
155 INT49930 Binding of Ighg1 21 0.37 13.27 2.43 5.00
156 INT102659 Gene_expression of CSF3 32 0.77 21.93 2.39 5.00
157 INT134374 Positive_regulation of Gene_expression of Cflar 4 0.14 2.12 2.18 5.00
158 INT48444 Localization of Csf3 28 0.72 14.85 2.11 5.00
159 INT228061 Positive_regulation of Localization of Hand1 8 0.26 6.39 2.06 5.00
160 INT14182 Gene_expression of CPB1 26 0.67 10.06 1.9 5.00
161 INT183147 Positive_regulation of Gene_expression of MEFV 6 0.50 4.67 1.73 5.00
162 INT48141 Binding of Csf3 18 0.39 9.93 1.71 5.00
163 INT97062 Binding of PML 10 0.41 11.63 1.65 5.00
164 INT126759 Negative_regulation of Nlrp3 5 0.41 2.95 1.58 5.00
165 INT95338 Positive_regulation of Positive_regulation of CASP1 9 0.49 4.61 1.43 5.00
166 INT53236 Positive_regulation of Binding of Il1 5 0.40 3.84 1.41 5.00
167 INT181868 Localization of ACLY 5 0.62 6.36 1.4 5.00
168 INT96073 Localization of Casp1 11 0.78 4.91 1.29 5.00
169 INT228328 Positive_regulation of Gene_expression of PYCARD 7 0.34 0.27 1.23 5.00
170 INT209915 Protein_catabolism of Il1 6 0.57 3.97 1.17 5.00
171 INT234422 Gene_expression of PML 14 0.75 15.93 1.14 5.00
172 INT91658 Localization of CASP1 5 0.77 0.89 1.04 5.00
173 INT209912 Gene_expression of Pycard 17 0.22 12.04 1.04 5.00
174 INT262340 Binding of TRIP10 6 0.36 1.45 0.96 5.00
175 INT116197 Positive_regulation of Gene_expression of CFLAR 6 0.67 7.11 0.9 5.00
176 INT109658 Gene_expression of IL1RAPL1 3 0.67 1.8 0.87 5.00
177 INT262726 Localization of PML 6 0.57 7.13 0.72 5.00
178 INT148291 Positive_regulation of CSF3 9 0.61 6.37 0.7 5.00
179 INT83194 Binding of APOH 4 0.17 3.92 0.66 5.00
180 INT18008 Negative_regulation of IL3 4 0.40 1.5 0.62 5.00
181 INT219136 Positive_regulation of Positive_regulation of Nlrp3 3 0.49 2.61 0.58 5.00
182 INT168448 Localization of Nlrp3 5 0.73 3.75 0.58 5.00
183 INT25602 Positive_regulation of THPO 5 0.69 4.55 0.57 5.00
184 INT103638 Negative_regulation of MEFV 7 0.39 5.88 0.54 5.00
185 INT277994 Binding of Trap1 7 0.26 6.21 0.53 5.00
186 INT211176 Binding of AGTRAP 1 0.01 0.38 0.47 5.00
187 INT56042 Binding of IGBP1 2 0.01 2.1 0.47 5.00
188 INT91665 Positive_regulation of Localization of CASP1 2 0.48 0.27 0.4 5.00
189 INT251556 Localization of Adam17 2 0.38 2 0.39 5.00
190 INT72455 Transcription of S100A8 3 0.69 1.66 0.36 5.00
191 INT119001 Regulation of ACLY 5 0.44 4.83 0.36 5.00
192 INT152276 Regulation of Positive_regulation of PLG 2 0.44 1.53 0.32 5.00
193 INT174272 Negative_regulation of Gene_expression of F3 5 0.14 4.06 0.31 5.00
194 INT298971 Positive_regulation of Localization of Casp1 2 0.06 0.97 0.28 5.00
195 INT212362 Positive_regulation of Gene_expression of CSF3 3 0.32 4.85 0.26 5.00
196 INT289317 Positive_regulation of Localization of PML 1 0.23 1.09 0.26 5.00
197 INT317821 Regulation of Gene_expression of Casp1 1 0.05 1.74 0.24 5.00
198 INT236278 Negative_regulation of CADPS 4 0.36 2.16 0.22 5.00
199 INT334889 Positive_regulation of Transcription of MRPL14 1 0.07 0.79 0.21 5.00
200 INT334883 Positive_regulation of Transcription of CBFA2T2 1 0.03 0.79 0.21 5.00
Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox