D:Radiation Pneumonitis

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Disease Term
Synonyms Fibroses Radiation, FIBROSIS RADIATION, Pneumonia Radiation, Pneumonias Radiation, Pneumonitides Radiation, Pneumonitis Radiation, Radiation Fibroses, Radiation Fibrosis, RADIATION PNEUMONIA, Radiation Pneumonias, Radiation Pneumonitides
Documents 73
Hot Single Events 35
Hot Interactions 3

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Radiation Pneumonitis. They are ordered first by their relevance to Radiation Pneumonitis and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT315194 Binding of SFRP1 and Slc10a1 1 0.02 8.85 0 100.00
2 INT315187 Binding of SFRP1 and COPD 1 0.01 4.47 0 100.00
3 INT240016 Binding of IL6 and POMT1 1 0.03 0.99 0.11 100.00
4 INT262750 GLYR1 Positive_regulation of THBS1 1 0.01 0.99 0 35.52
5 INT262751 Binding of PTCH1 and SMO 1 0.25 1.29 0.1 12.16
6 INT230437 Binding of PDX1 and HRCT1 1 0.04 2.45 0.43 5.00
7 INT262760 Binding of TEP1 and CD163L1 1 0.00 1.65 0.37 5.00
8 INT230438 Binding of PDX1 and HAUS7 1 0.02 2.29 0.35 5.00
9 INT193695 Il2 Positive_regulation of Ctla4 1 0.01 1.63 0.18 5.00
10 INT193693 Binding of Myd88 and Pain1 1 0.14 0.82 0.13 5.00
11 INT193697 Apaf1 Positive_regulation of CASP9 1 0.02 1.84 0.12 5.00
12 INT262758 MRGPRF Positive_regulation of Transcription of NFE2L3 1 0.01 1.25 0.09 5.00
13 INT262754 MRGPRF Positive_regulation of NFE2L3 1 0.01 1.24 0.09 5.00
14 INT262755 MRGPRF Positive_regulation of NFE2L2 1 0.18 1.24 0.09 5.00
15 INT193691 Positive_regulation of Positive_regulation of Bcr 1 0.01 0.07 0.08 5.00
16 INT193692 IgG2a Positive_regulation of Bcr 1 0.02 0.07 0.08 5.00
17 INT193694 IgG2a Positive_regulation of Tlr9 1 0.05 0.07 0.08 5.00
18 INT262781 Birc5 Regulation of TEP1 1 0.00 0.49 0.05 5.00
19 INT262780 Birc5 Regulation of CD163L1 1 0.00 0.49 0.05 5.00
20 INT262757 SMO Positive_regulation of Regulation of GLI1 1 0.34 0.6 0.04 5.00
21 INT193696 Binding of CD8A and Trav6-3 1 0.00 0.85 0 5.00
22 INT262759 PIK3CG Positive_regulation of MTOR 1 0.38 0.54 0 5.00
23 INT176131 Binding of AKT1 and PIK3CG 2 0.15 1.08 0 5.00
24 INT262752 IGHA1 Positive_regulation of IGKV2D-19 1 0.00 1.39 0 5.00
25 INT262756 STAT3 Positive_regulation of NFE2L2 1 0.31 1.55 0 5.00
26 INT262753 Binding of MTOR and PIK3CG 1 0.20 0.82 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Radiation Pneumonitis. They are ordered first by their pain relevance and then by number of times they were reported in Radiation Pneumonitis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT315192 Binding of Slc10a1 1 0.03 2.4 0 100.00
2 INT315189 Binding of SFRP1 1 0.15 2.96 0 100.00
3 INT47038 Gene_expression of SFRP1 14 0.67 9.6 0.63 100.00
4 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 100.00
5 INT9239 Regulation of Gene_expression of IL6 106 0.61 75.24 36.53 100.00
6 INT287913 Positive_regulation of Gene_expression of SFRP1 2 0.25 2.12 0.05 100.00
7 INT206866 Positive_regulation of SFRP1 7 0.51 3.97 0.05 100.00
8 INT315191 Localization of Slc10a1 1 0.07 1.01 0 100.00
9 INT226288 Negative_regulation of SFRP1 6 0.43 4.45 0 100.00
10 INT11051 Positive_regulation of Gene_expression of IL6 415 0.69 319.21 109.3 99.96
11 INT240019 Positive_regulation of Gene_expression of POMT1 7 0.09 5.56 0.2 99.96
12 INT133875 Gene_expression of POMT1 26 0.58 17.1 1.48 99.88
13 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 99.82
14 INT239596 Positive_regulation of POMT1 29 0.40 9.92 2.8 99.72
15 INT240022 Positive_regulation of Binding of POMT1 2 0.09 1.12 0.29 99.52
16 INT64723 Regulation of Positive_regulation of IL6 13 0.61 12.59 5.19 99.24
17 INT52264 Gene_expression of IK 180 0.77 90.87 51.87 99.08
18 INT197715 Negative_regulation of POMT1 8 0.10 4.35 0.18 99.02
19 INT10838 Positive_regulation of IL8 381 0.70 295.51 101.62 98.92
20 INT11047 Positive_regulation of Positive_regulation of IL6 45 0.66 28.7 9.37 98.68
21 INT4369 Gene_expression of Ldha 157 0.76 88.12 22.45 98.36
22 INT22708 Gene_expression of MUC1 297 0.78 232.71 24.19 97.88
23 INT70222 Binding of POMT1 22 0.37 11.73 1.69 97.60
24 INT12082 Localization of IL6 365 0.81 241.78 105.78 96.80
25 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 96.64
26 INT69437 Positive_regulation of ROS1 328 0.58 222.83 40.56 94.28
27 INT74563 Positive_regulation of Gene_expression of ROS1 258 0.61 168.18 34.08 94.28
28 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 94.16
29 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83 93.88
30 INT315193 Regulation of Slc10a1 1 0.03 0.57 0 93.48
31 INT85417 Positive_regulation of Gene_expression of IK 17 0.09 9.38 5.73 91.24
32 INT671 Positive_regulation of Cea 221 0.69 164.5 47.79 87.04
33 INT240020 Regulation of Binding of IL6 4 0.36 4.38 0.46 83.36
34 INT86437 Binding of IL6 154 0.48 121.22 29.3 82.44
35 INT19628 Regulation of Xdh 6 0.45 1.9 1.07 81.00
36 INT72782 Positive_regulation of HCC 41 0.40 63.74 2.46 77.44
37 INT240017 Regulation of Gene_expression of POMT1 1 0.04 2.62 0 76.56
38 INT174816 Binding of IL6R 14 0.09 11.26 3.63 75.72
39 INT105284 Gene_expression of Ocln 39 0.78 14.98 5.08 75.00
40 INT124077 Negative_regulation of Ocln 13 0.57 8.62 1.8 75.00
41 INT124076 Binding of Ocln 3 0.37 1.01 0.34 75.00
42 INT38303 Binding of Gpt 21 0.47 15.84 3.43 72.88
43 INT48901 Negative_regulation of IL6 186 0.57 136.33 57.87 70.84
44 INT1624 Gene_expression of Cea 212 0.76 180.44 34.21 68.92
45 INT2139 Negative_regulation of Cea 55 0.43 43.59 9.14 68.92
46 INT69952 Positive_regulation of IK 45 0.32 16.08 14.59 66.16
47 INT17565 Regulation of Gpt 85 0.60 43.64 13.68 57.16
48 INT193670 Regulation of Csda 1 0.60 0.54 0 55.12
49 INT9210 Regulation of IL6 166 0.62 125.61 49.95 50.00
50 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 42.16
51 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 41.08
52 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 40.92
53 INT505 Positive_regulation of GPT 89 0.67 69.38 14.94 38.88
54 INT11340 Positive_regulation of SLC17A5 120 0.67 113.52 14.5 38.88
55 INT136503 Negative_regulation of KDR 46 0.48 43.1 1.86 36.16
56 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 35.16
57 INT255189 Positive_regulation of Localization of Fbn1 1 0.45 1.03 0.19 33.48
58 INT255190 Positive_regulation of Gene_expression of Fbn1 1 0.68 1.03 0.19 33.48
59 INT23468 Gene_expression of Fbn1 7 0.76 8.04 0.76 32.96
60 INT202924 Localization of Fbn1 2 0.69 1.12 0.19 32.36
61 INT134795 Positive_regulation of Scrib 30 0.22 36.91 2.81 13.76
62 INT262772 Binding of SMO 1 0.27 0.59 0.05 12.16
63 INT135299 Binding of PTCH1 10 0.48 12.16 0.84 7.20
64 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 5.00
65 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
66 INT6481 Binding of TNF 624 0.48 510.2 214.82 5.00
67 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 5.00
68 INT867 Gene_expression of IFNA1 930 0.78 594.85 168.03 5.00
69 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 5.00
70 INT9852 Positive_regulation of Gpt 563 0.70 364.64 146.82 5.00
71 INT60694 Gene_expression of Il10 567 0.78 369.48 143.69 5.00
72 INT20374 Gene_expression of Il4 515 0.76 306.15 114.12 5.00
73 INT27096 Positive_regulation of Nfkb1 325 0.70 195.11 109.06 5.00
74 INT60526 Gene_expression of IL10 449 0.78 292.71 107.84 5.00
75 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 5.00
76 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 5.00
77 INT11381 Positive_regulation of IL1B 330 0.70 209.31 100.9 5.00
78 INT77435 Positive_regulation of Nos2 343 0.70 208.49 91.43 5.00
79 INT6849 Localization of IL1B 229 0.81 112.56 69.63 5.00
80 INT3375 Gene_expression of IGHE 535 0.77 387.47 65.46 5.00
81 INT11807 Gene_expression of Il2 266 0.78 112 64.97 5.00
82 INT5058 Positive_regulation of IFNA1 356 0.70 245.75 60.52 5.00
83 INT17564 Gene_expression of Gpt 322 0.75 208.51 60.36 5.00
84 INT63975 Positive_regulation of Il10 175 0.68 134.13 54.69 5.00
85 INT20375 Gene_expression of Hand1 213 0.60 148.51 54.53 5.00
86 INT19775 Localization of Il1 183 0.78 145.5 50.91 5.00
87 INT3987 Positive_regulation of IGHE 316 0.70 283.2 40.16 5.00
88 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 5.00
89 INT16323 Gene_expression of pr 62 0.66 36.14 38.26 5.00
90 INT77307 Gene_expression of Bcl2 399 0.77 319.77 38 5.00
91 INT6484 Binding of IL1B 122 0.47 75.84 35.07 5.00
92 INT13186 Positive_regulation of Il4 113 0.68 71.22 31.4 5.00
93 INT21900 Gene_expression of Mthfd1 150 0.75 69.47 27.03 5.00
94 INT17331 Positive_regulation of JUN 132 0.69 60.4 27.03 5.00
95 INT10835 Regulation of IL8 79 0.49 53.04 24.14 5.00
96 INT83797 Gene_expression of Bcl2l1 124 0.77 94.55 22.39 5.00
97 INT84732 Positive_regulation of Hand2 81 0.69 62.07 22 5.00
98 INT170444 Binding of Gopc 172 0.39 45.05 20.71 5.00
99 INT89396 Phosphorylation of AKT1 225 0.82 111.66 19.61 5.00
100 INT106097 Localization of pr 20 0.62 12.01 19.46 5.00
101 INT18311 Positive_regulation of CD8A 145 0.69 113.48 19.44 5.00
102 INT11803 Positive_regulation of Il2 62 0.70 31.44 18.93 5.00
103 INT10833 Regulation of Gene_expression of IL8 68 0.62 38.74 18.46 5.00
104 INT171060 Gene_expression of PDX1 72 0.75 72.57 17.97 5.00
105 INT9220 Gene_expression of Ighg1 125 0.77 85.74 15.92 5.00
106 INT116465 Gene_expression of Birc5 241 0.78 192.31 15.32 5.00
107 INT60197 Gene_expression of JUN 90 0.78 42.32 14.61 5.00
108 INT20420 Gene_expression of MYC 99 0.75 49.32 14.36 5.00
109 INT100938 Positive_regulation of Il13 47 0.69 42.11 14.36 5.00
110 INT99780 Positive_regulation of Cxcl10 43 0.69 39.67 13.27 5.00
111 INT81629 Positive_regulation of Fas 58 0.70 59.63 12.94 5.00
112 INT8210 Positive_regulation of Gene_expression of INS 188 0.68 146.57 12.83 5.00
113 INT31990 Positive_regulation of SOD1 124 0.69 67.79 12.52 5.00
114 INT27268 Localization of Gtf3a 71 0.21 56.93 12.51 5.00
115 INT112003 Localization of ROS1 94 0.73 66.32 12.16 5.00
116 INT81640 Positive_regulation of Gene_expression of Bcl2 106 0.69 84.58 11.63 5.00
117 INT2491 Regulation of Cea 38 0.61 26.18 10.95 5.00
118 INT51265 Phosphorylation of TNF 32 0.81 25.33 10.75 5.00
119 INT15054 Gene_expression of Mme 48 0.77 42.52 10.63 5.00
120 INT58449 Binding of Mthfd1 47 0.47 22.02 10.29 5.00
121 INT10019 Binding of CD8A 57 0.36 31.49 10.08 5.00
122 INT3988 Positive_regulation of Gene_expression of IGHE 98 0.68 91.46 9.61 5.00
123 INT97439 Positive_regulation of Il5 46 0.60 25.6 9.47 5.00
124 INT3846 Positive_regulation of GSR 60 0.50 35.16 9.37 5.00
125 INT149138 Binding of PDX1 27 0.37 32.62 9.33 5.00
126 INT73497 Regulation of IL10 33 0.45 22.6 9.19 5.00
127 INT193663 Binding of Pain1 9 0.36 8.84 8.04 5.00
128 INT80220 Positive_regulation of Bcl2 71 0.58 57.73 7.86 5.00
129 INT39417 Gene_expression of Fcer2a 65 0.76 32.1 7.37 5.00
130 INT102572 Gene_expression of Ccnd1 79 0.69 56.37 7.34 5.00
131 INT99942 Positive_regulation of Fasl 37 0.68 32.61 6.92 5.00
132 INT160562 Localization of Cd4 49 0.71 27.58 6.78 5.00
133 INT60700 Gene_expression of Itgax 93 0.71 51.89 6.57 5.00
134 INT53196 Binding of Cd4 44 0.47 27.28 5.85 5.00
135 INT84704 Positive_regulation of Nqo1 18 0.70 18.64 5.65 5.00
136 INT80657 Gene_expression of SLC17A5 50 0.75 39.98 5.44 5.00
137 INT59891 Positive_regulation of GSTK1 46 0.67 17.66 5.33 5.00
138 INT89104 Binding of TGFB1 29 0.44 13.67 5.12 5.00
139 INT68244 Positive_regulation of Ighg1 60 0.61 48.86 5.01 5.00
140 INT116150 Positive_regulation of Ddit3 26 0.67 22.58 5.01 5.00
141 INT116464 Negative_regulation of Birc5 53 0.59 45.4 4.91 5.00
142 INT63839 Binding of CRS 31 0.41 34.05 4.7 5.00
143 INT188672 Positive_regulation of Tlr9 15 0.67 13.1 4.48 5.00
144 INT83794 Positive_regulation of Gene_expression of Bcl2l1 26 0.69 16.89 4.28 5.00
145 INT745 Gene_expression of Afp 65 0.78 52.89 4.24 5.00
146 INT138698 Gene_expression of Txn1 15 0.77 11.71 4.24 5.00
147 INT83798 Negative_regulation of Gene_expression of Bcl2l1 28 0.58 20.26 4.21 5.00
148 INT57645 Gene_expression of GSTK1 54 0.62 21.05 4.2 5.00
149 INT504 Gene_expression of GPT 42 0.75 27.54 3.99 5.00
150 INT86919 Negative_regulation of PIK3CG 40 0.57 21.16 3.97 5.00
151 INT89966 Negative_regulation of Fas 26 0.58 24.83 3.5 5.00
152 INT130295 Gene_expression of Abcg2 21 0.75 9.75 3.42 5.00
153 INT133214 Regulation of PDX1 9 0.34 10.26 3.36 5.00
154 INT20419 Negative_regulation of Gene_expression of MYC 19 0.57 9.7 3.29 5.00
155 INT81453 Positive_regulation of Gene_expression of JUN 18 0.50 9.39 3.23 5.00
156 INT157401 Gene_expression of Ctla4 21 0.65 15.43 3.2 5.00
157 INT35910 Binding of Mme 8 0.37 4.79 3.16 5.00
158 INT140555 Positive_regulation of Localization of ROS1 29 0.55 23.82 3.14 5.00
159 INT93936 Gene_expression of Pgp 10 0.59 3.43 3.04 5.00
160 INT12887 Positive_regulation of Mme 9 0.60 15.41 2.93 5.00
161 INT50765 Positive_regulation of Fcer2a 23 0.68 10.22 2.92 5.00
162 INT8670 Negative_regulation of Afp 27 0.58 19.85 2.87 5.00
163 INT41721 Negative_regulation of MTOR 40 0.58 32.49 2.83 5.00
164 INT89401 Negative_regulation of Phosphorylation of AKT1 68 0.58 35.61 2.8 5.00
165 INT116463 Negative_regulation of Gene_expression of Birc5 40 0.59 33.99 2.74 5.00
166 INT1922 Positive_regulation of CEACAM7 32 0.70 33.31 2.72 5.00
167 INT171058 Negative_regulation of PDX1 5 0.32 9.31 2.72 5.00
168 INT77925 Negative_regulation of TEP1 21 0.53 15.23 2.62 5.00
169 INT40315 Gene_expression of Abcc1 10 0.76 5.66 2.53 5.00
170 INT28865 Positive_regulation of Gene_expression of Cea 21 0.57 15.03 2.52 5.00
171 INT147349 Localization of Bcl2 13 0.65 7.83 2.31 5.00
172 INT182318 Regulation of Birc5 25 0.60 23.58 2.29 5.00
173 INT133766 Negative_regulation of Fasl 11 0.56 11.28 2.27 5.00
174 INT72890 Positive_regulation of Gene_expression of Fcer2a 12 0.17 6.81 2.25 5.00
175 INT101641 Gene_expression of Mcl1 25 0.54 20.3 2.23 5.00
176 INT9908 Negative_regulation of IAPP 29 0.57 19.37 2.12 5.00
177 INT71870 Positive_regulation of Gene_expression of Mme 6 0.48 4.27 2 5.00
178 INT171323 Phosphorylation of IL1B 5 0.57 4.13 1.94 5.00
179 INT101243 Regulation of STAT3 12 0.62 9.98 1.92 5.00
180 INT171059 Localization of PDX1 8 0.56 6.7 1.9 5.00
181 INT133269 Positive_regulation of PDX1 10 0.54 9.77 1.9 5.00
182 INT188678 Binding of Tlr7 14 0.32 6.6 1.89 5.00
183 INT56925 Negative_regulation of TSC1 54 0.52 63.39 1.87 5.00
184 INT172961 Localization of Egf 26 0.71 16.74 1.81 5.00
185 INT61913 Binding of IgG2a 10 0.47 5.04 1.64 5.00
186 INT168681 Gene_expression of BMS1 5 0.37 2.7 1.62 5.00
187 INT41719 Gene_expression of MTOR 27 0.77 19.43 1.44 5.00
188 INT108325 Gene_expression of Scrib 26 0.39 48.33 1.39 5.00
189 INT140296 Negative_regulation of XIAP 9 0.45 13.61 1.37 5.00
190 INT183065 Positive_regulation of Gene_expression of PDX1 7 0.54 6.58 1.29 5.00
191 INT20397 Positive_regulation of Itgax 12 0.46 6.48 1.19 5.00
192 INT60542 Positive_regulation of Gene_expression of GSTK1 11 0.39 6.21 1.13 5.00
193 INT155696 Gene_expression of PIK3CG 16 0.65 8.54 1.02 5.00
194 INT230440 Gene_expression of HAUS7 1 0.04 4.13 1.02 5.00
195 INT130297 Positive_regulation of Gene_expression of Abcc1 3 0.56 1.06 0.97 5.00
196 INT135260 Negative_regulation of Pgp 4 0.42 1.13 0.95 5.00
197 INT62031 Gene_expression of Cd19 27 0.65 10.39 0.93 5.00
198 INT87329 Positive_regulation of Gene_expression of Itgax 15 0.64 10.85 0.93 5.00
199 INT193666 Gene_expression of Gpr83 2 0.14 0.92 0.91 5.00
200 INT57596 Regulation of Gene_expression of ALB 9 0.44 5.44 0.91 5.00
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