D:Raynauds Disease

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pChart

Disease Term
Synonyms INDUSTRIAL WHITE FINGER, Raynaud Disease, Raynaud Phenomenon, Raynaud S Disease, Raynaud S Disorder, Raynaud S Dysfunction, Raynaud S Syndrome, VIBRATION INDUCED WHITE FINGER
Documents 54
Hot Single Events 5
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Raynauds Disease. They are ordered first by their relevance to Raynauds Disease and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT121651 Binding of CXCL12 and CXCR4 13 0.48 17.61 3.52 5.00
2 INT183781 Binding of IL6 and INS 6 0.22 8.97 1.87 5.00
3 INT254355 PF4 Positive_regulation of IFNA1 1 0.04 1.23 1.26 5.00
4 INT254352 Binding of CXCR4 and Positive_regulation of Gene_expression of CXCL12 1 0.14 1.8 0.66 5.00
5 INT254356 Binding of IFNG and IL1B 1 0.00 1.87 0.51 5.00
6 INT254357 Binding of IFNA1 and IL1B 1 0.00 1.88 0.51 5.00
7 INT254348 Binding of ANGPT1 and TEK 1 0.04 1.72 0.48 5.00
8 INT254360 Binding of EPAS1 and HIF1A 3 0.39 3.36 0.46 5.00
9 INT254347 FASLG Negative_regulation of Gene_expression of CHI3L1 1 0.13 0.92 0.42 5.00
10 INT254350 FASLG Negative_regulation of Gene_expression of VEGFA 1 0.06 0.92 0.42 5.00
11 INT254353 Binding of VEGFA and MMRN1 1 0.00 0.81 0.28 5.00
12 INT254359 IL1B Positive_regulation of Localization of VEGFA 1 0.01 0.87 0.26 5.00
13 INT254349 Positive_regulation of Binding of EPAS1 and HIF1A 1 0.00 0.92 0.23 5.00
14 INT254351 Binding of ANGPT2 and TEK 1 0.04 0.87 0.22 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Raynauds Disease. They are ordered first by their pain relevance and then by number of times they were reported in Raynauds Disease. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT30382 Negative_regulation of Ednra 21 0.42 12.06 8.19 98.48
2 INT129358 Gene_expression of ELOVL1 23 0.66 29.39 2.83 97.12
3 INT130176 Positive_regulation of Gene_expression of CRP 125 0.66 137.06 25.9 96.52
4 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 95.20
5 INT6624 Gene_expression of Pth 135 0.76 110.27 27.54 85.80
6 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64 75.52
7 INT4259 Positive_regulation of Npr1 262 0.70 49.37 123.11 67.76
8 INT1149 Binding of ecs 19 0.37 13.67 3.9 66.80
9 INT4216 Gene_expression of CD40LG 328 0.78 256.02 44.23 62.96
10 INT22804 Positive_regulation of ALDOC 8 0.41 8.07 1.02 56.08
11 INT712 Positive_regulation of LDHA 160 0.70 175.25 19.11 55.28
12 INT20631 Positive_regulation of CHKB 166 0.69 109.86 17.92 54.88
13 INT66423 Binding of ELOVL1 52 0.40 61.63 5.16 42.56
14 INT170179 Binding of Vwf 4 0.36 0.93 0 36.40
15 INT170178 Regulation of Elovl1 1 0.26 0.86 0.08 29.60
16 INT13556 Gene_expression of CD4 367 0.78 230.82 41.74 20.48
17 INT170528 Negative_regulation of Gene_expression of CD4 25 0.41 17.98 3.6 20.48
18 INT148087 Positive_regulation of RTEL1 9 0.17 5.13 0.41 20.24
19 INT226818 Negative_regulation of RTEL1 1 0.06 1.17 0.41 17.40
20 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
21 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
22 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 5.00
23 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 5.00
24 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 5.00
25 INT915 Positive_regulation of PRL 342 0.70 141.96 104.31 5.00
26 INT56298 Gene_expression of IL4 306 0.78 182.18 72.92 5.00
27 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 5.00
28 INT9196 Gene_expression of PTGS1 215 0.77 96.99 60.5 5.00
29 INT46637 Gene_expression of CXCL10 172 0.78 121.94 57.74 5.00
30 INT1579 Gene_expression of PRL 279 0.78 119.2 55.41 5.00
31 INT101992 Localization of VEGFA 413 0.81 258.23 36.15 5.00
32 INT53475 Gene_expression of MRI1 116 0.59 77.68 33.98 5.00
33 INT73498 Gene_expression of IL13 117 0.44 83.85 32.26 5.00
34 INT100861 Binding of CRP 179 0.48 175.2 26.45 5.00
35 INT9079 Gene_expression of PPBP 52 0.75 31.2 21.52 5.00
36 INT48692 Binding of VEGFA 345 0.48 210.3 21.31 5.00
37 INT157463 Gene_expression of CX3CL1 55 0.62 69.05 19.75 5.00
38 INT5160 Localization of PTAFR 61 0.80 42.6 19.16 5.00
39 INT20622 Gene_expression of LDHA 107 0.76 77.97 16.3 5.00
40 INT143230 Gene_expression of CRYGD 61 0.65 52.11 15.93 5.00
41 INT116465 Gene_expression of Birc5 241 0.78 192.31 15.32 5.00
42 INT180497 Binding of MRI1 45 0.42 28.35 14.77 5.00
43 INT105387 Gene_expression of HIF1A 116 0.77 98.62 14.66 5.00
44 INT88544 Gene_expression of MMRN1 102 0.75 68.8 14.55 5.00
45 INT91544 Gene_expression of CHI3L1 60 0.75 77.72 13.9 5.00
46 INT108485 Gene_expression of CXCL12 61 0.75 49.34 13.79 5.00
47 INT92574 Gene_expression of CXCL5 51 0.78 24.87 11.89 5.00
48 INT176607 Gene_expression of Cx3cl1 27 0.75 19.51 11.32 5.00
49 INT157466 Gene_expression of CX3CR1 14 0.76 20.6 10.76 5.00
50 INT100379 Positive_regulation of HIF1A 69 0.69 57.31 10.4 5.00
51 INT32581 Positive_regulation of C4B 9 0.45 11.17 9.05 5.00
52 INT8903 Gene_expression of IFNA2 58 0.71 38.23 8.68 5.00
53 INT32579 Binding of C4B 14 0.36 14.99 7.79 5.00
54 INT32580 Gene_expression of C4B 24 0.75 17.95 7.75 5.00
55 INT10863 Positive_regulation of Ldlr 45 0.68 31.06 7.05 5.00
56 INT127691 Gene_expression of CXCL1 23 0.66 18.11 7.04 5.00
57 INT117189 Binding of CXCR4 34 0.37 24.27 5.81 5.00
58 INT19541 Gene_expression of Ptgir 22 0.65 15.42 5.39 5.00
59 INT45753 Localization of CD40LG 45 0.79 32.31 5.28 5.00
60 INT128161 Gene_expression of DDIT3 20 0.75 17.14 5.13 5.00
61 INT74447 Gene_expression of Vwf 39 0.76 21.96 4.66 5.00
62 INT33466 Negative_regulation of C4B 14 0.43 9.06 4.64 5.00
63 INT3128 Negative_regulation of PON1 30 0.59 26.19 4.57 5.00
64 INT78995 Negative_regulation of Agtr2 26 0.42 13.05 4.56 5.00
65 INT17324 Negative_regulation of Plg 26 0.38 13.5 4.05 5.00
66 INT130351 Positive_regulation of Vwf 18 0.59 5.99 3.48 5.00
67 INT47949 Positive_regulation of ELOVL1 19 0.42 29.78 3.3 5.00
68 INT175262 Binding of SH2B2 18 0.36 22.85 3.18 5.00
69 INT4488 Gene_expression of TSHB 10 0.41 4.69 3.09 5.00
70 INT105390 Positive_regulation of Gene_expression of HIF1A 27 0.49 26.3 2.88 5.00
71 INT208588 Binding of CXCR2 11 0.48 6.43 2.68 5.00
72 INT72165 Gene_expression of CXCL6 8 0.52 4.76 2.6 5.00
73 INT108482 Positive_regulation of Gene_expression of CXCL12 7 0.53 9.72 2.36 5.00
74 INT112364 Negative_regulation of HIF1A 22 0.57 16.95 2.13 5.00
75 INT153718 Gene_expression of ANGPT1 15 0.45 10.82 2.13 5.00
76 INT3723 Binding of PON1 9 0.46 5.83 2.13 5.00
77 INT37394 Localization of ecs 9 0.34 6.41 2.11 5.00
78 INT11390 Gene_expression of PF4 5 0.65 3.09 2.07 5.00
79 INT216065 Localization of C4B 2 0.21 2.86 2.01 5.00
80 INT184410 Gene_expression of ASF1A 6 0.11 5.51 1.94 5.00
81 INT153719 Gene_expression of TEK 10 0.49 9.82 1.88 5.00
82 INT200223 Positive_regulation of EPAS1 21 0.17 21.95 1.7 5.00
83 INT22075 Positive_regulation of Gene_expression of IFNA2 7 0.64 4.7 1.45 5.00
84 INT168373 Gene_expression of Capns1 4 0.58 4.55 1.34 5.00
85 INT160553 Regulation of C4B 3 0.14 1.54 1.16 5.00
86 INT254370 Gene_expression of THBS2 1 0.06 2.24 1 5.00
87 INT157573 Localization of Vwf 9 0.69 2.93 0.97 5.00
88 INT117083 Localization of RTEL1 5 0.60 9.1 0.8 5.00
89 INT246524 Binding of QPCT 4 0.05 3.65 0.72 5.00
90 INT221874 Binding of Ctrcts 3 0.00 1.29 0.71 5.00
91 INT242745 Regulation of FANCE 2 0.28 1.98 0.66 5.00
92 INT254369 Negative_regulation of COL18A1 2 0.16 1.61 0.61 5.00
93 INT254368 Gene_expression of XCR1 1 0.20 1.03 0.55 5.00
94 INT142006 Positive_regulation of COL18A1 2 0.41 3.01 0.53 5.00
95 INT186882 Gene_expression of RTEL1 13 0.27 13.45 0.49 5.00
96 INT331114 Gene_expression of DURS1 2 0.49 3.93 0.45 5.00
97 INT254367 Transcription of TEK 1 0.14 1.08 0.36 5.00
98 INT197194 Binding of DURS1 3 0.27 4.2 0.33 5.00
99 INT254372 Negative_regulation of TEK 1 0.12 1.05 0.31 5.00
100 INT170180 Protein_catabolism of Vwf 1 0.64 0.85 0.14 5.00
101 INT143209 Gene_expression of ALDOC 2 0.18 0.87 0.14 5.00
102 INT265852 Gene_expression of Dhps 1 0.08 0.7 0.05 5.00
103 INT281008 Negative_regulation of Gene_expression of Capns1 1 0.03 1.79 0.04 5.00
104 INT170177 Positive_regulation of Elovl1 1 0.49 0.67 0 5.00
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