D:Referred Pain

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Disease Term
Synonyms FACIAL PAIN REFERRED, Referred Facial Pain
Documents 705
Hot Single Events 58
Hot Interactions 2

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Referred Pain. They are ordered first by their relevance to Referred Pain and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT163903 Binding of EFNB1 and Src 1 0.03 0.56 0.29 92.60
2 INT132701 Adarb1 Negative_regulation of Gene_expression of Fos 1 0.01 0.73 1.07 90.44
3 INT181490 Tryptase Positive_regulation of F2rl1 1 0.13 1.83 1.21 5.00
4 INT292531 Il10 Negative_regulation of Positive_regulation of Mapk14 1 0.15 1.13 1.06 5.00
5 INT292530 Il10 Negative_regulation of Localization of Il1a 1 0.06 1.09 0.97 5.00
6 INT197470 Binding of Sostdc1 and Hbtq 1 0.00 0.87 0.87 5.00
7 INT181491 Tryptase Positive_regulation of HTR1A 1 0.02 0.93 0.61 5.00
8 INT165580 Binding of Akt1 and Grin2b 1 0.02 0.2 0.32 5.00
9 INT353861 Binding of Mgp and Phdlc1 1 0.01 5.09 0.16 5.00
10 INT353865 Binding of CHI3L1 and Lepr 1 0.00 1.88 0.03 5.00
11 INT197466 Dpcd Positive_regulation of Sostdc1 1 0.00 0 0 5.00
12 INT197467 Binding of Dpcd and Memor1 1 0.00 0.12 0 5.00
13 INT197469 Binding of Dpcd and Hbtq 1 0.00 0 0 5.00
14 INT197468 Dpcd Positive_regulation of Hbtq 1 0.00 0 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Referred Pain. They are ordered first by their pain relevance and then by number of times they were reported in Referred Pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT71350 Positive_regulation of Tpnr1 3 0.01 3.92 4.08 100.00
2 INT108535 Positive_regulation of TNNI1 7 0.67 5.54 2.12 99.86
3 INT4729 Positive_regulation of PPT1 19 0.67 7.11 17.83 99.80
4 INT116737 Localization of Mif 63 0.81 52.97 28.11 99.48
5 INT232323 Regulation of SMCP 1 0.23 3.07 3.06 99.12
6 INT113961 Regulation of PPT1 6 0.26 3.87 6.09 98.88
7 INT165258 Binding of BC013712 1 0.06 0.85 1.02 98.84
8 INT58061 Gene_expression of Trpv1 1117 0.78 451.54 637.59 98.28
9 INT39507 Positive_regulation of TXNRD1 37 0.68 12.47 14.25 98.08
10 INT19396 Regulation of Rac1 66 0.53 37.41 30.01 97.84
11 INT80394 Localization of Vom1r68 2 0.05 0.19 0.64 97.60
12 INT6056 Negative_regulation of Gene_expression of Fos 601 0.59 193.05 386.84 97.52
13 INT5200 Gene_expression of Fos 3083 0.78 894.43 1639.02 97.12
14 INT89842 Phosphorylation of Src 34 0.69 9.57 13.08 94.64
15 INT153959 Phosphorylation of GRIN1 8 0.80 4.07 6.18 94.64
16 INT89844 Positive_regulation of Phosphorylation of Src 10 0.43 4.71 4.95 94.64
17 INT130440 Phosphorylation of GRIN2B 2 0.79 2.93 1.79 94.64
18 INT163895 Positive_regulation of Phosphorylation of GRIN2B 1 0.09 0.99 0.48 94.64
19 INT163896 Positive_regulation of Phosphorylation of GRIN1 1 0.67 0.55 0.29 94.64
20 INT246297 Positive_regulation of RGS1 1 0.01 0.78 0.78 94.52
21 INT269142 Positive_regulation of Mia1 1 0.34 0.98 0.71 93.48
22 INT50055 Negative_regulation of Rac1 36 0.50 19.74 8.98 93.20
23 INT11937 Localization of Il6 228 0.81 139.83 64.39 92.88
24 INT112054 Negative_regulation of Negative_regulation of DMD 12 0.44 5.02 0.45 92.88
25 INT1027 Gene_expression of Lbp 132 0.77 106.7 54.16 92.72
26 INT27651 Gene_expression of S100A12 45 0.76 52.25 10.51 92.64
27 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 92.28
28 INT16167 Negative_regulation of DMD 186 0.57 108.71 15.25 92.20
29 INT45266 Negative_regulation of Nenf 3 0.38 2.46 3.59 91.84
30 INT155507 Binding of EFNB1 2 0.35 0.74 0.43 91.84
31 INT2541 Binding of Calca 200 0.48 67.14 134.62 91.40
32 INT120966 Positive_regulation of Pik3cb 34 0.68 15.15 16.59 91.28
33 INT82876 Regulation of IFNAR1 6 0.26 6.69 3.73 90.84
34 INT5202 Positive_regulation of Gene_expression of Fos 1163 0.70 319.28 684 90.04
35 INT137961 Localization of Ppt1 1 0.64 2.89 3.09 89.44
36 INT84079 Positive_regulation of MDH2 2 0.45 0.18 0.92 89.28
37 INT99088 Gene_expression of HPT 5 0.59 9.1 6.72 88.96
38 INT87623 Gene_expression of PPT1 9 0.75 5.32 7.65 88.64
39 INT17997 Positive_regulation of Mch 23 0.49 12.71 6.67 88.48
40 INT2543 Positive_regulation of Calca 787 0.70 331.13 592.08 87.20
41 INT3300 Positive_regulation of Gene_expression of Calca 179 0.70 77.76 144.2 87.20
42 INT4895 Positive_regulation of Gene_expression of Tac4 16 0.69 2.46 11.51 87.20
43 INT77339 Positive_regulation of RRM2 5 0.41 1.36 2.88 87.00
44 INT11141 Negative_regulation of Gene_expression of Avp 23 0.59 3.85 12.19 86.56
45 INT4758 Positive_regulation of Localization of Calca 557 0.70 138.55 411.04 86.52
46 INT64202 Positive_regulation of Trpv1 643 0.70 249.66 397.42 86.52
47 INT97848 Positive_regulation of Localization of Trpv1 18 0.50 7.66 13.36 86.52
48 INT1912 Gene_expression of Calca 1152 0.78 453.25 739.84 86.32
49 INT38731 Localization of Trpv1 138 0.81 52.73 90.49 86.12
50 INT53460 Gene_expression of tn 13 0.66 7.97 5.2 86.08
51 INT4887 Gene_expression of Tac4 70 0.77 11.66 40.97 84.88
52 INT2542 Localization of Calca 2008 0.81 518.3 1408.65 84.60
53 INT7180 Negative_regulation of Trib3 180 0.51 68.48 88.01 84.40
54 INT22834 Negative_regulation of CYP21A2 28 0.58 23.07 7.13 83.80
55 INT74237 Positive_regulation of Ppt1 3 0.49 2.92 2.32 83.08
56 INT1273 Gene_expression of Avp 356 0.78 90.56 138.7 82.48
57 INT53475 Gene_expression of MRI1 116 0.59 77.68 33.98 81.84
58 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 81.08
59 INT10534 Positive_regulation of Trib3 209 0.60 78.75 81.48 77.52
60 INT246298 Localization of RGS1 1 0.02 1.72 1.6 75.96
61 INT37615 Gene_expression of ESCO1 6 0.72 1.1 4.15 75.00
62 INT22269 Gene_expression of IGKV1-5 32 0.50 1.71 1.95 75.00
63 INT22956 Gene_expression of Mpg 2 0.68 1.48 0.25 71.56
64 INT182847 Regulation of Binding of Il10 2 0.41 1.26 1.15 69.20
65 INT103289 Binding of Il10 15 0.35 13.67 7.42 68.76
66 INT48953 Positive_regulation of Nos2 486 0.70 239.85 131.87 68.72
67 INT138457 Gene_expression of Hbtq 13 0.02 1.68 2 67.52
68 INT197463 Positive_regulation of Gene_expression of Hbtq 1 0.01 0.57 0.9 67.52
69 INT232317 Gene_expression of C12orf39 4 0.75 2.21 2.16 66.84
70 INT217429 Positive_regulation of SLC9A6 22 0.38 42.17 0.67 64.48
71 INT48955 Gene_expression of Nos2 753 0.78 403.87 208.08 64.40
72 INT174341 Localization of Mpg 1 0.30 1.12 0.36 64.08
73 INT350 Localization of Th 79 0.80 10.26 41.17 64.08
74 INT4740 Gene_expression of Th 298 0.78 61.27 154.03 63.36
75 INT84080 Localization of MDH2 2 0.55 0.57 0.45 60.32
76 INT61950 Regulation of Positive_regulation of Nos2 17 0.43 9.01 4.87 58.96
77 INT53459 Negative_regulation of Gene_expression of tn 2 0.42 0.85 1.13 58.24
78 INT40750 Gene_expression of Mif 61 0.78 34.59 20.28 58.20
79 INT7134 Localization of KNG1 127 0.79 65.73 67.97 57.76
80 INT16166 Positive_regulation of DMD 348 0.67 133.22 15.06 55.92
81 INT4890 Gene_expression of Ppt1 51 0.77 8.93 21.83 53.72
82 INT116736 Positive_regulation of Mif 40 0.70 31.93 15.37 52.00
83 INT4509 Gene_expression of IgG 426 0.76 293.69 56.64 51.36
84 INT269144 Gene_expression of Mia1 8 0.59 11.84 6.16 49.36
85 INT233945 Positive_regulation of Expi 5 0.04 2.53 3.46 46.88
86 INT2649 Regulation of Calca 433 0.62 146.05 330.95 44.08
87 INT60126 Regulation of Trpv1 186 0.62 85.53 133.4 43.60
88 INT58192 Positive_regulation of MRI1 86 0.61 53.81 24.68 40.08
89 INT246299 Negative_regulation of RGS1 1 0.01 0.85 0.81 37.04
90 INT170646 Negative_regulation of Fig4 213 0.37 81.29 46.92 29.76
91 INT121493 Gene_expression of XRCC1 55 0.65 73.43 2.76 29.04
92 INT63365 Gene_expression of Spg21 21 0.65 12.9 7.37 28.80
93 INT132700 Positive_regulation of Trpc1 6 0.39 4.33 3.89 27.44
94 INT8700 Positive_regulation of Positive_regulation of Calca 56 0.67 21.69 53.66 26.40
95 INT20210 Localization of Ngf 69 0.79 46.22 38.57 25.52
96 INT573 Negative_regulation of C3 60 0.59 41.37 7.78 25.00
97 INT516 Negative_regulation of Mif 13 0.59 6.69 6.08 22.56
98 INT72949 Binding of Mif 31 0.46 23.12 11.65 22.40
99 INT24326 Gene_expression of Ngf 346 0.78 218.67 184.71 17.76
100 INT27954 Positive_regulation of Gene_expression of Ngf 87 0.70 57.91 51.96 17.76
101 INT48238 Regulation of Gene_expression of Ngf 25 0.62 11.48 16.42 17.76
102 INT125884 Positive_regulation of CHI3L1 15 0.62 34.04 4.43 17.28
103 INT125885 Positive_regulation of Gene_expression of CHI3L1 8 0.49 10.8 2.64 17.28
104 INT73234 Positive_regulation of Lbp 13 0.69 12.55 8.57 16.08
105 INT171145 Positive_regulation of Fig4 274 0.59 93.55 69.81 15.32
106 INT91544 Gene_expression of CHI3L1 60 0.75 77.72 13.9 15.20
107 INT2780 Regulation of Gene_expression of Penk 265 0.62 32.45 143.88 12.00
108 INT796 Gene_expression of Penk 1902 0.78 275.47 1057.59 10.32
109 INT5680 Gene_expression of Ngf 530 0.78 264.29 310.56 9.68
110 INT61664 Regulation of GRIN1 38 0.60 16.45 25.35 8.60
111 INT126177 Positive_regulation of Atf3 14 0.70 14.34 5.56 7.84
112 INT269145 Positive_regulation of Gene_expression of Mia1 1 0.34 0.98 1.23 7.84
113 INT16254 Positive_regulation of Gene_expression of Ngf 144 0.70 80.61 82.08 7.76
114 INT170025 Gene_expression of Fig4 588 0.67 183.27 113.32 5.84
115 INT170033 Positive_regulation of Gene_expression of Fig4 59 0.43 20.99 16.69 5.84
116 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
117 INT292 Localization of Penk 876 0.81 88.44 669.14 5.00
118 INT728 Positive_regulation of Penk 1068 0.70 186.9 636.87 5.00
119 INT5228 Positive_regulation of Fos 934 0.70 209.8 503.87 5.00
120 INT1395 Negative_regulation of Penk 537 0.59 87.33 389.81 5.00
121 INT76660 Gene_expression of Trpv1 691 0.78 329.46 386.42 5.00
122 INT18357 Gene_expression of TRPV1 825 0.78 307.11 382.81 5.00
123 INT5591 Regulation of Gene_expression of Fos 425 0.62 129.06 265.78 5.00
124 INT11377 Positive_regulation of Ngf 331 0.70 206.5 238 5.00
125 INT626 Localization of CALCA 289 0.81 125.39 221.15 5.00
126 INT798 Positive_regulation of Gene_expression of Penk 394 0.70 78.53 203.07 5.00
127 INT94952 Positive_regulation of Mapk14 305 0.70 197.83 186.61 5.00
128 INT15516 Gene_expression of Crp 711 0.77 615.33 173.09 5.00
129 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 5.00
130 INT2451 Positive_regulation of Avp 355 0.70 102.66 147.69 5.00
131 INT90910 Phosphorylation of Grin1 150 0.82 68.23 139.24 5.00
132 INT48895 Gene_expression of Il10 333 0.78 221.2 138.52 5.00
133 INT5842 Gene_expression of Gfap 372 0.78 153.71 127.71 5.00
134 INT1878 Binding of HLA-B 440 0.48 321.16 127.36 5.00
135 INT5008 Localization of Calca 204 0.81 80.35 125.16 5.00
136 INT218 Positive_regulation of Th 245 0.70 40.5 120.1 5.00
137 INT1026 Binding of Lbp 207 0.48 150.96 119.16 5.00
138 INT50674 Gene_expression of PTGS2 459 0.78 253.33 118.51 5.00
139 INT7341 Positive_regulation of Grin1 169 0.70 65.86 118.38 5.00
140 INT12339 Localization of IL8 437 0.81 251.87 117.39 5.00
141 INT65731 Gene_expression of Cnr1 234 0.78 63.82 109.34 5.00
142 INT5940 Negative_regulation of Avp 236 0.59 67.86 101.2 5.00
143 INT74826 Gene_expression of Slc1a2 131 0.78 61.83 100.84 5.00
144 INT293 Protein_catabolism of Penk 161 1.00 11.71 98.45 5.00
145 INT104000 Phosphorylation of Grin2b 73 0.82 48.34 93.48 5.00
146 INT77435 Positive_regulation of Nos2 343 0.70 208.49 91.43 5.00
147 INT4830 Binding of Trpv1 158 0.48 45.11 84.2 5.00
148 INT5590 Negative_regulation of Fos 144 0.59 40.94 81.98 5.00
149 INT15769 Gene_expression of Il1b 146 0.78 114.51 75.35 5.00
150 INT98621 Regulation of Trpv1 121 0.62 79.24 75.23 5.00
151 INT79506 Gene_expression of Grin2b 122 0.78 43.71 73.42 5.00
152 INT5969 Gene_expression of Il1a 221 0.75 96.31 71.38 5.00
153 INT5843 Positive_regulation of Gfap 184 0.70 108.2 70.21 5.00
154 INT65733 Positive_regulation of Cnr1 125 0.70 40.27 67.33 5.00
155 INT4960 Positive_regulation of CSF2 285 0.70 256.73 65.73 5.00
156 INT9664 Binding of LBP 127 0.48 94.9 63.42 5.00
157 INT65730 Gene_expression of Cnr2 129 0.78 60.15 63.1 5.00
158 INT39153 Positive_regulation of PTGS2 182 0.70 96.16 60.6 5.00
159 INT48891 Positive_regulation of Il10 143 0.70 101.42 56.72 5.00
160 INT83602 Positive_regulation of Gene_expression of TRPV1 114 0.70 51.19 56.35 5.00
161 INT31186 Negative_regulation of Insrr 81 0.37 24.91 55.94 5.00
162 INT647 Gene_expression of SGCG 211 0.75 78.46 55.82 5.00
163 INT52692 Gene_expression of Ptgs2 160 0.78 85.06 55.73 5.00
164 INT117713 Phosphorylation of Akt1 275 0.82 95.82 54.34 5.00
165 INT77855 Gene_expression of Pain1 55 0.75 67.42 54.1 5.00
166 INT48952 Negative_regulation of Nos2 204 0.59 101.73 53.15 5.00
167 INT1456 Regulation of Oprl1 61 0.62 19.5 52.87 5.00
168 INT50334 Negative_regulation of Cnr1 84 0.58 30.86 51.75 5.00
169 INT19775 Localization of Il1 183 0.78 145.5 50.91 5.00
170 INT74827 Positive_regulation of Gene_expression of Slc1a2 52 0.70 26.54 50.63 5.00
171 INT40777 Positive_regulation of Akt1 163 0.69 59.41 49.43 5.00
172 INT6864 Positive_regulation of Gene_expression of Gfap 110 0.70 59.01 47.07 5.00
173 INT9383 Localization of TRPV1 98 0.81 33.23 46.24 5.00
174 INT98498 Binding of Trpv1 75 0.48 33.67 44.4 5.00
175 INT2774 Binding of Crp 241 0.48 195.89 44.39 5.00
176 INT92517 Gene_expression of Grin1 105 0.78 29.53 39.43 5.00
177 INT55135 Positive_regulation of Gene_expression of PTGS2 137 0.70 80.32 38.46 5.00
178 INT11854 Gene_expression of Il1rl1 57 0.77 30.19 38.25 5.00
179 INT82054 Positive_regulation of Grin2b 56 0.70 17.45 37.14 5.00
180 INT66005 Regulation of Cnr1 47 0.61 19.21 34.52 5.00
181 INT34465 Regulation of Oprd1 34 0.45 7.14 34.29 5.00
182 INT19759 Gene_expression of LBP 77 0.77 56.44 33.23 5.00
183 INT719 Negative_regulation of SGCG 96 0.57 47.91 30.22 5.00
184 INT67912 Gene_expression of GRIN1 75 0.77 28.99 29.28 5.00
185 INT15610 Localization of GOPC 223 0.65 68.26 28.7 5.00
186 INT17825 Gene_expression of Flvcr2 44 0.68 12.58 28.08 5.00
187 INT177581 Regulation of Fig4 113 0.41 39.26 27.75 5.00
188 INT14690 Localization of CSF2 124 0.80 85.17 27.26 5.00
189 INT5966 Localization of Il1a 50 0.78 22.91 26.54 5.00
190 INT9088 Negative_regulation of LBP 48 0.58 33.06 25.89 5.00
191 INT40776 Gene_expression of Akt1 99 0.77 34.91 24.39 5.00
192 INT70503 Regulation of Gene_expression of Nos2 71 0.62 44 24.01 5.00
193 INT58288 Positive_regulation of Gene_expression of Crp 83 0.61 82.23 23.7 5.00
194 INT49553 Regulation of Gene_expression of Gfap 42 0.62 17.04 23.65 5.00
195 INT11746 Positive_regulation of Il1a 65 0.63 42.94 23.54 5.00
196 INT9292 Positive_regulation of SGCG 93 0.67 35.13 23.48 5.00
197 INT47741 Negative_regulation of Flvcr2 43 0.51 5.72 23.37 5.00
198 INT125190 Regulation of Gene_expression of Trpv1 38 0.62 32.57 23.2 5.00
199 INT1221 Regulation of SGCG 65 0.60 24.21 22.94 5.00
200 INT11077 Positive_regulation of Htr3a 63 0.67 15.61 22.7 5.00
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