D:Renal Artery Obstruction

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Disease Term
Synonyms OBSTRUCTION RENAL ARTERY, Obstructions Renal Artery, Renal Artery Obstructions, Renal Artery Stenoses, Renal Artery Stenosis, Stenoses Renal Artery, Stenosis Renal Artery
Documents 133
Hot Single Events 38
Hot Interactions 2

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Renal Artery Obstruction. They are ordered first by their relevance to Renal Artery Obstruction and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT39143 ras Positive_regulation of Gene_expression of REN 1 0.01 1.35 0.45 100.00
2 INT39142 ras Positive_regulation of REN 1 0.01 1.34 0.45 100.00
3 INT177714 Binding of GALNT3 and REN 1 0.01 2.36 0.12 79.00
4 INT258018 Binding of AGT and RASGRP1 1 0.00 1.59 0.1 69.48
5 INT258017 Binding of AGT and ANGPT2 3 0.11 2.35 0.19 68.84
6 INT258014 Binding of ANGPT2 and RASGRP1 1 0.00 1.58 0.1 68.84
7 INT182775 Binding of PTH and ROS1 1 0.04 1.73 0.04 44.00
8 INT66504 Binding of Agt and Agtr1a 8 0.39 3.78 1.78 5.00
9 INT225158 Binding of CDK2 and CDKN1A 7 0.30 3.26 1.02 5.00
10 INT90387 ROS1 Positive_regulation of NFKB1 4 0.32 2.35 0.87 5.00
11 INT391 Binding of Agt and Ace 2 0.33 1.5 0.68 5.00
12 INT352496 AVP Regulation of Gene_expression of CRS 1 0.27 2.47 0.59 5.00
13 INT230786 Binding of AGT and ACE 4 0.15 2.53 0.34 5.00
14 INT229363 Negative_regulation of Binding of Agt and Agtr1a 2 0.22 0.9 0.32 5.00
15 INT72445 Binding of AGT and REN 3 0.34 0.88 0.31 5.00
16 INT182771 ROS1 Positive_regulation of NFKB1 Positive_regulation of CRP 1 0.00 3.83 0.28 5.00
17 INT288911 AGT Positive_regulation of CYBB 3 0.07 2.96 0.28 5.00
18 INT229360 Agt Positive_regulation of Agtr1a 2 0.48 1.26 0.2 5.00
19 INT338898 Binding of PECAM1 and PTPN11 1 0.04 0.38 0.19 5.00
20 INT182772 ROS1 Positive_regulation of NFKB1 Positive_regulation of IL1B 1 0.00 1.89 0.14 5.00
21 INT182773 ROS1 Positive_regulation of NFKB1 Positive_regulation of IL6 1 0.00 1.9 0.14 5.00
22 INT182780 NFKB1 Positive_regulation of IL1B 1 0.00 1.8 0.14 5.00
23 INT182782 NFKB1 Positive_regulation of IL6 1 0.00 1.8 0.14 5.00
24 INT258016 AGTR1 Positive_regulation of EGFR 1 0.15 1.24 0.13 5.00
25 INT229359 Agt Positive_regulation of Binding of Agtr1a 1 0.25 0.9 0.12 5.00
26 INT352497 AGT Positive_regulation of Binding of CRS 1 0.14 0.87 0.11 5.00
27 INT229364 Ace Positive_regulation of Protein_catabolism of KNG1 1 0.02 0.86 0.11 5.00
28 INT286432 Binding of ANTXR2 and Gtf3a 1 0.00 3.56 0.1 5.00
29 INT338901 Binding of PECAM1 and PTPN6 1 0.03 0.18 0.1 5.00
30 INT267969 Binding of AGT and TRPV1 1 0.00 0.44 0.08 5.00
31 INT267970 Negative_regulation of Binding of AGT and TRPV1 1 0.00 0.44 0.08 5.00
32 INT258021 Positive_regulation of Binding of CDK2 and CDKN1A 1 0.11 0.84 0.07 5.00
33 INT338902 Binding of MAX and MYC 1 0.02 0.23 0.06 5.00
34 INT258015 Binding of ANGPT2 and REN 1 0.01 0.59 0.05 5.00
35 INT258012 ANGPT2 Positive_regulation of Binding of AGTR1 and ANGPT2 1 0.00 0.29 0.04 5.00
36 INT258020 Binding of AGTR1 and ANGPT2 1 0.03 0.29 0.04 5.00
37 INT283226 Binding of ACE and CC2D1A 1 0.11 2.37 0.04 5.00
38 INT327451 HTN1 Positive_regulation of Adra1a 1 0.00 1.36 0.03 5.00
39 INT338900 MYC Positive_regulation of Gene_expression of TP73 1 0.05 0.27 0.03 5.00
40 INT182784 IGF1 Positive_regulation of Gene_expression of INS 1 0.02 1.87 0 5.00
41 INT286433 Negative_regulation of Binding of Shbg and ANTXR2 1 0.06 1.29 0 5.00
42 INT182804 Binding of ETV3 and T2DM 1 0.10 2.62 0 5.00
43 INT338899 THPO Positive_regulation of STAT3 1 0.16 0 0 5.00
44 INT286434 Binding of Shbg and ANTXR2 1 0.05 1.29 0 5.00
45 INT182778 IGF1 Positive_regulation of Gene_expression of ETV3 1 0.03 1.89 0 5.00
46 INT229362 Negative_regulation of Agtr1a Positive_regulation of Positive_regulation of Agtr2 1 0.05 1 0 5.00
47 INT182774 Binding of ETV3 and SAE1 1 0.00 1.17 0 5.00
48 INT182783 INS Positive_regulation of Gene_expression of ETV3 1 0.01 1.89 0 5.00
49 INT182777 IAPP Positive_regulation of Gene_expression of ETV3 1 0.06 1.88 0 5.00
50 INT227796 Binding of Acsl1 and Nos3 1 0.16 1.16 0 5.00
51 INT182776 IAPP Positive_regulation of Gene_expression of INS 1 0.03 1.87 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Renal Artery Obstruction. They are ordered first by their pain relevance and then by number of times they were reported in Renal Artery Obstruction. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT655 Positive_regulation of Localization of REN 86 0.70 32.41 13.56 100.00
2 INT654 Localization of REN 250 0.81 75.12 47.86 100.00
3 INT81688 Binding of ras 32 0.41 30.13 4.02 100.00
4 INT22080 Regulation of ras 40 0.53 36.24 4.44 100.00
5 INT16205 Localization of ras 25 0.73 18.99 1.85 100.00
6 INT156639 Localization of Hcm 5 0.64 7.65 0.16 100.00
7 INT375 Positive_regulation of REN 293 0.70 152.46 47.55 99.98
8 INT3299 Positive_regulation of AGT 126 0.68 79.45 21.91 99.98
9 INT21943 Positive_regulation of Positive_regulation of AGT 6 0.46 3.29 0.75 99.98
10 INT39948 Binding of FLNA 45 0.42 58.05 4.27 99.96
11 INT4336 Negative_regulation of Gene_expression of REN 13 0.58 7.22 1.43 99.20
12 INT1724 Negative_regulation of ACE 437 0.59 315.64 74.48 99.16
13 INT660 Negative_regulation of REN 194 0.59 82.06 29.46 98.84
14 INT661 Gene_expression of REN 100 0.78 48.21 11.36 98.60
15 INT16359 Positive_regulation of Gene_expression of AGT 30 0.49 28.27 6.14 98.52
16 INT27835 Regulation of Positive_regulation of Ren 10 0.44 2.27 2.38 98.36
17 INT177716 Gene_expression of GALNT3 7 0.53 6.91 0.75 98.32
18 INT3330 Gene_expression of AGT 149 0.76 98.65 22.73 97.86
19 INT21687 Positive_regulation of ras 143 0.58 97.34 27.31 97.68
20 INT314 Positive_regulation of Ren 212 0.70 66.68 55.56 97.68
21 INT113948 Gene_expression of FLNA 32 0.73 36.06 4.81 96.28
22 INT19146 Negative_regulation of Apoa2 19 0.36 5.34 6.73 95.68
23 INT27989 Positive_regulation of Gene_expression of REN 18 0.55 12.69 2.11 95.52
24 INT2140 Regulation of REN 104 0.62 28.24 24.49 94.96
25 INT34715 Regulation of Regulation of AGT 2 0.37 0.96 0.75 94.16
26 INT3962 Regulation of AGT 50 0.62 20.96 13.01 92.44
27 INT60552 Localization of TNNI3 56 0.79 20.05 1.44 89.44
28 INT613 Gene_expression of Alb 268 0.78 149.84 42.78 87.32
29 INT27591 Negative_regulation of Gene_expression of Alb 30 0.58 17.03 5.99 87.32
30 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 87.32
31 INT30738 Negative_regulation of Gene_expression of ALB 32 0.59 19.01 5.04 87.32
32 INT251 Regulation of INS 398 0.62 232.47 55.04 85.60
33 INT194546 Positive_regulation of Gene_expression of Dbp 9 0.28 2.93 0.36 85.08
34 INT21103 Gene_expression of Dbp 48 0.61 22.6 5.59 84.88
35 INT177717 Positive_regulation of Gene_expression of GALNT3 2 0.03 2.84 0.18 82.52
36 INT27988 Negative_regulation of Positive_regulation of AGT 11 0.42 5.71 2.27 82.28
37 INT262293 Gene_expression of CC2D1A 21 0.40 44.64 1.5 81.28
38 INT1533 Negative_regulation of AGT 105 0.42 46.54 16.92 80.36
39 INT1179 Negative_regulation of Ace 157 0.59 67.03 30.46 79.00
40 INT55479 Localization of Epo 13 0.81 6.1 1.53 76.08
41 INT712 Positive_regulation of LDHA 160 0.70 175.25 19.11 74.64
42 INT87340 Negative_regulation of BCAR1 8 0.38 6.96 2.63 73.76
43 INT20664 Binding of ACE 60 0.48 35.27 9.16 73.04
44 INT8065 Binding of AGT 54 0.48 20.54 10.85 69.48
45 INT37544 Binding of ANGPT2 9 0.19 6.51 0.69 68.84
46 INT3971 Positive_regulation of Alb 175 0.70 98.46 36.45 68.56
47 INT214618 Transcription of FLNA 4 0.51 8.06 0.37 68.00
48 INT22525 Localization of CPB1 3 0.61 0.98 0.45 67.44
49 INT6726 Positive_regulation of Edn1 118 0.70 65.96 24.07 67.40
50 INT7105 Gene_expression of pad 54 0.77 63.68 8.8 65.92
51 INT46646 Localization of FLNA 19 0.73 18.83 2.53 64.36
52 INT33220 Negative_regulation of ras 110 0.58 70.21 9.19 59.52
53 INT4479 Negative_regulation of Positive_regulation of REN 17 0.56 6.1 3.27 56.12
54 INT34692 Negative_regulation of Positive_regulation of ras 5 0.45 3.86 1.08 56.12
55 INT8068 Gene_expression of RASGRP1 29 0.54 15.1 1.37 52.48
56 INT10982 Negative_regulation of Agtr1a 42 0.58 22.42 10.29 51.72
57 INT183080 Gene_expression of Hypt 5 0.14 7.53 0.85 50.88
58 INT342921 Localization of Hypt 1 0.15 1.38 0.08 50.16
59 INT72482 Negative_regulation of ANTXR2 3 0.24 9.06 1.03 48.04
60 INT286427 Regulation of ANTXR2 1 0.26 1.2 0.27 46.28
61 INT25402 Binding of Ptcra 10 0.34 3.54 1.85 45.68
62 INT286430 Phosphorylation of ANTXR2 1 0.36 2.57 0 44.96
63 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83 44.00
64 INT74563 Positive_regulation of Gene_expression of ROS1 258 0.61 168.18 34.08 44.00
65 INT6512 Gene_expression of PTH 103 0.77 76.29 6.33 44.00
66 INT6514 Positive_regulation of Gene_expression of PTH 28 0.67 30.28 1.37 44.00
67 INT341297 Positive_regulation of Localization of HDDC3 1 0.06 0 0 42.92
68 INT341300 Localization of HDDC3 1 0.10 0 0 42.56
69 INT744 Positive_regulation of PTH 130 0.70 95.02 11.7 40.96
70 INT234 Binding of Alb 151 0.48 52.34 32.97 40.72
71 INT24643 Gene_expression of Hdlcl1 30 0.73 26.83 1.9 40.00
72 INT1721 Negative_regulation of HP 148 0.42 86.82 16.89 39.68
73 INT197715 Negative_regulation of POMT1 8 0.10 4.35 0.18 38.12
74 INT10888 Binding of Vwf 32 0.46 22.87 5.21 36.84
75 INT338740 Transcription of Src 1 0.43 1.24 0.07 35.00
76 INT138844 Positive_regulation of CC2D1A 25 0.41 41.36 1.92 34.00
77 INT182794 Gene_expression of CPLX1 1 0.06 5.57 0.17 33.16
78 INT182799 Positive_regulation of Gene_expression of CPLX1 1 0.04 1.49 0.03 33.16
79 INT11859 Positive_regulation of Tbxa2r 44 0.61 22.62 9.61 31.00
80 INT75183 Negative_regulation of TNNI3 19 0.53 9.34 1.32 30.08
81 INT5401 Gene_expression of DBH 17 0.78 1.92 8.01 29.28
82 INT20665 Gene_expression of ACE 87 0.78 51.71 14.19 28.76
83 INT2824 Positive_regulation of HTN1 10 0.40 10.41 1.4 22.48
84 INT9832 Gene_expression of Shbg 96 0.75 56.71 12.19 21.12
85 INT5286 Gene_expression of ANTXR2 46 0.75 21.06 3.41 21.12
86 INT12334 Positive_regulation of CYP3A 34 0.70 6.77 7.85 20.64
87 INT72483 Binding of ANTXR2 15 0.35 16.09 0.63 19.44
88 INT100222 Binding of Src 9 0.26 5.41 5.37 15.72
89 INT10171 Binding of Gtf3a 33 0.36 19.84 5.1 11.08
90 INT7678 Localization of Alb 142 0.81 80.93 22.49 10.48
91 INT19847 Positive_regulation of Localization of Alb 21 0.70 13.89 4.16 10.48
92 INT107386 Negative_regulation of AGTR1 37 0.55 35.94 5.15 9.76
93 INT45612 Negative_regulation of pad 8 0.37 6.74 2.57 9.44
94 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
95 INT9131 Positive_regulation of Prkcg 431 0.70 130.8 302.41 5.00
96 INT63932 Positive_regulation of Ephb1 537 0.70 259.67 296.14 5.00
97 INT16868 Gene_expression of Il6 807 0.78 499.48 256.57 5.00
98 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 5.00
99 INT15516 Gene_expression of Crp 711 0.77 615.33 173.09 5.00
100 INT1303 Negative_regulation of Npr1 278 0.55 35.1 156.78 5.00
101 INT812 Localization of INS 1026 0.81 515.6 145.31 5.00
102 INT4259 Positive_regulation of Npr1 262 0.70 49.37 123.11 5.00
103 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 5.00
104 INT48593 Positive_regulation of NOS1 420 0.68 226.15 114.71 5.00
105 INT11051 Positive_regulation of Gene_expression of IL6 415 0.69 319.21 109.3 5.00
106 INT60526 Gene_expression of IL10 449 0.78 292.71 107.84 5.00
107 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 5.00
108 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 5.00
109 INT86024 Gene_expression of PPARA 736 0.78 497.93 91.14 5.00
110 INT214 Localization of AVP 370 0.81 208.51 91.09 5.00
111 INT48767 Negative_regulation of NOS1 312 0.59 154.25 90.32 5.00
112 INT71789 Positive_regulation of MAPK1 396 0.70 234.44 89.27 5.00
113 INT54571 Positive_regulation of NFKB1 263 0.70 138.99 87.32 5.00
114 INT10534 Positive_regulation of Trib3 209 0.60 78.75 81.48 5.00
115 INT12536 Localization of Prkcg 101 0.80 36.37 73.81 5.00
116 INT48244 Gene_expression of Il4 172 0.76 132.38 73.42 5.00
117 INT7134 Localization of KNG1 127 0.79 65.73 67.97 5.00
118 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64 5.00
119 INT67614 Positive_regulation of PPARA 438 0.68 293.28 63.61 5.00
120 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07 5.00
121 INT18981 Gene_expression of ABAT 78 0.68 38.35 61.36 5.00
122 INT1536 Negative_regulation of NA 244 0.55 52.67 59.79 5.00
123 INT11491 Positive_regulation of KNG1 128 0.67 60.41 58.74 5.00
124 INT9408 Positive_regulation of Crp 296 0.69 242.27 57.35 5.00
125 INT1199 Positive_regulation of INS 579 0.70 399.64 50.43 5.00
126 INT48718 Positive_regulation of PRKCA 109 0.69 36.16 46.49 5.00
127 INT683 Positive_regulation of AVP 173 0.70 74.55 46.41 5.00
128 INT71786 Phosphorylation of MAPK1 256 0.82 110.09 46.17 5.00
129 INT1322 Positive_regulation of Localization of INS 293 0.70 120.86 45.98 5.00
130 INT145266 Gene_expression of IL17A 154 0.75 109.83 45.33 5.00
131 INT3361 Positive_regulation of Esr1 273 0.69 208.53 44.81 5.00
132 INT48929 Regulation of Ephb1 71 0.62 24.42 42.11 5.00
133 INT69437 Positive_regulation of ROS1 328 0.58 222.83 40.56 5.00
134 INT3252 Negative_regulation of INS 428 0.59 271.65 39.52 5.00
135 INT385 Gene_expression of Agt 182 0.78 63.62 37.91 5.00
136 INT390 Positive_regulation of Agt 170 0.70 61.47 36.08 5.00
137 INT103094 Binding of PPARA 308 0.47 177.26 34.75 5.00
138 INT8905 Gene_expression of EDN1 215 0.78 157.1 34.19 5.00
139 INT17381 Gene_expression of Tbxa2r 146 0.78 65.01 34.15 5.00
140 INT16960 Gene_expression of Crp 166 0.76 116.21 34.07 5.00
141 INT12537 Positive_regulation of Localization of Prkcg 36 0.70 14.57 33.81 5.00
142 INT63933 Negative_regulation of Positive_regulation of Ephb1 53 0.58 22.83 33.43 5.00
143 INT3913 Positive_regulation of ABAT 47 0.69 22.73 33.4 5.00
144 INT1159 Negative_regulation of Agt 133 0.59 40.14 31.67 5.00
145 INT48693 Regulation of VEGFA 268 0.62 191.88 31.52 5.00
146 INT56072 Negative_regulation of NFKB1 94 0.59 53.16 28.19 5.00
147 INT3076 Regulation of KNG1 52 0.60 20.39 27.89 5.00
148 INT6624 Gene_expression of Pth 135 0.76 110.27 27.54 5.00
149 INT12681 Regulation of Trib3 76 0.53 23.92 26.58 5.00
150 INT100861 Binding of CRP 179 0.48 175.2 26.45 5.00
151 INT9682 Positive_regulation of IGF1 238 0.70 120.03 26.36 5.00
152 INT130176 Positive_regulation of Gene_expression of CRP 125 0.66 137.06 25.9 5.00
153 INT11159 Gene_expression of EGFR 698 0.78 548.93 25.69 5.00
154 INT23937 Gene_expression of EDNRA 103 0.65 55.63 24.67 5.00
155 INT79061 Positive_regulation of NOS2 92 0.65 58.89 23.96 5.00
156 INT682 Negative_regulation of AVP 97 0.59 50.67 23.91 5.00
157 INT71781 Phosphorylation of MAPK3 62 0.80 27.73 23.73 5.00
158 INT50039 Positive_regulation of Il4 48 0.55 34.8 23.34 5.00
159 INT825 Negative_regulation of ADRA1D 54 0.58 20.25 22.78 5.00
160 INT16996 Gene_expression of PRTN3 113 0.75 85.61 22.57 5.00
161 INT84732 Positive_regulation of Hand2 81 0.69 62.07 22 5.00
162 INT1756 Negative_regulation of DNAH8 105 0.59 42.73 20.24 5.00
163 INT89484 Gene_expression of TNFRSF11B 119 0.76 53.57 19.67 5.00
164 INT4260 Negative_regulation of Positive_regulation of Npr1 29 0.43 4.39 19.57 5.00
165 INT23533 Gene_expression of CA2 110 0.75 30.81 19.4 5.00
166 INT12725 Positive_regulation of Racgap1 66 0.68 32.74 19.29 5.00
167 INT70614 Gene_expression of FAS 118 0.75 112.33 19.01 5.00
168 INT3952 Negative_regulation of ALB 116 0.59 72.18 18.35 5.00
169 INT28215 Gene_expression of CDKN1A 196 0.76 113.9 18.3 5.00
170 INT133647 Negative_regulation of HDAC9 149 0.57 106.84 17.9 5.00
171 INT6791 Binding of NA 55 0.46 5.36 17.59 5.00
172 INT29555 Positive_regulation of CALM1 58 0.69 14.09 17.37 5.00
173 INT13510 Gene_expression of ERBB2 530 0.78 405.68 16.79 5.00
174 INT653 Negative_regulation of Localization of REN 67 0.59 20.33 16.7 5.00
175 INT6129 Positive_regulation of Localization of AVP 63 0.70 30.44 16.64 5.00
176 INT2066 Localization of Agt 56 0.80 9.95 16.25 5.00
177 INT9525 Regulation of Positive_regulation of Prkcg 20 0.62 7.82 16.18 5.00
178 INT65659 Positive_regulation of STAT3 132 0.70 69.56 15.95 5.00
179 INT9783 Gene_expression of INSRR 81 0.50 32.99 15.52 5.00
180 INT75434 Gene_expression of Il13 27 0.52 26.19 15.4 5.00
181 INT170335 Gene_expression of INCENP 176 0.54 91.62 15.31 5.00
182 INT2630 Positive_regulation of Shbg 134 0.70 65.26 15.19 5.00
183 INT153776 Positive_regulation of IL17A 42 0.64 34.58 14.82 5.00
184 INT2758 Binding of Dbp 36 0.44 8.3 14.47 5.00
185 INT34952 Regulation of ABAT 28 0.61 6.05 14.39 5.00
186 INT42979 Positive_regulation of INSRR 47 0.32 12.24 14.38 5.00
187 INT20420 Gene_expression of MYC 99 0.75 49.32 14.36 5.00
188 INT80688 Positive_regulation of Positive_regulation of MAPK1 72 0.69 39.35 14.11 5.00
189 INT16919 Gene_expression of IL36RN 48 0.48 32.78 13.83 5.00
190 INT18773 Localization of ALB 117 0.80 69.18 13.8 5.00
191 INT86646 Positive_regulation of SCN10A 71 0.69 50.61 13.24 5.00
192 INT62441 Gene_expression of ABCC1 56 0.78 21.01 12.93 5.00
193 INT4199 Binding of Agt 76 0.48 21.06 12.66 5.00
194 INT2129 Positive_regulation of F2 83 0.70 58.95 12.63 5.00
195 INT83201 Gene_expression of NOS3 93 0.78 47.16 12.48 5.00
196 INT8548 Gene_expression of HP 86 0.77 47.62 11.94 5.00
197 INT53038 Positive_regulation of Agtr1a 35 0.67 23.76 11.68 5.00
198 INT3602 Negative_regulation of Shbg 148 0.53 69.05 11.65 5.00
199 INT14204 Protein_catabolism of KNG1 41 0.96 20.94 11.47 5.00
200 INT37541 Gene_expression of SPP1 113 0.77 68.54 11.35 5.00
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