D:Renal Insufficiency

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Disease Term
Synonyms Insufficiency Kidney, Kidney Insufficiencies, Kidney Insufficiency, RENAL INSUFFICIENCIES
Documents 1188
Hot Single Events 200
Hot Interactions 3

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Renal Insufficiency. They are ordered first by their relevance to Renal Insufficiency and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT344405 Binding of EGFR and Spp1 1 0.09 1.34 0 95.40
2 INT215978 Binding of HPT and Pth 1 0.01 0.92 0 89.84
3 INT286432 Binding of ANTXR2 and Gtf3a 1 0.00 3.56 0.1 87.44
4 INT344402 Binding of Crp and Spp1 1 0.05 2.92 0.28 79.68
5 INT311223 GLP1R Regulation of Localization of GCG 1 0.16 0.74 0 72.84
6 INT345421 IFNA1 Positive_regulation of Eif2ak2 2 0.03 1.25 0.3 72.72
7 INT291018 Binding of NSF and USE1 1 0.03 0.98 0.46 69.20
8 INT291019 Negative_regulation of Binding of NSF and USE1 1 0.03 0.59 0.26 69.20
9 INT332588 Binding of RAPH1 and MND1 1 0.01 3.88 0.07 65.36
10 INT241853 Binding of SLC40A1 and HAMP 3 0.41 5.35 0.43 64.08
11 INT283226 Binding of ACE and CC2D1A 1 0.11 2.37 0.04 62.04
12 INT350981 VHL Regulation of XRCC1 1 0.01 1.42 0 61.64
13 INT308652 Binding of Renbp and Nps 1 0.01 1.38 0.09 59.48
14 INT351032 Binding of CD80 and CD96 1 0.01 0.36 0.09 44.24
15 INT351031 Binding of CD28 and CD96 1 0.02 0.36 0.09 44.24
16 INT149117 Binding of CD80 and CTLA4 31 0.52 12.7 7.73 43.28
17 INT186126 Binding of CD28 and CTLA4 9 0.52 4.13 3.12 43.28
18 INT194647 Binding of CD28 and CD80 15 0.40 4.9 3.22 43.00
19 INT339903 Binding of SCN5A and ZGLP1 1 0.01 0.18 0.22 42.56
20 INT225782 Tnfrsf11b Regulation of Enpp1 1 0.12 0.74 0 39.52
21 INT270780 BPs Positive_regulation of DMD 1 0.02 0 0 38.12
22 INT71518 Binding of INSRR and Nisch 1 0.00 0.22 0.35 38.00
23 INT339901 Binding of INS and SCN5A 1 0.01 0.18 0.2 35.68
24 INT84085 Binding of Gucy1a2 and Nisch 1 0.00 0.22 0.35 34.40
25 INT213239 Binding of TNXA and Serpinc1 1 0.00 0.16 0.08 32.00
26 INT225805 Binding of SNRNP70 and Enpp1 1 0.42 1.43 0.09 29.08
27 INT225808 SNRNP70 Regulation of Enpp1 1 0.30 0.71 0.04 29.08
28 INT225774 SNRNP70 Regulation of Binding of Insr and Enpp1 1 0.03 0.77 0.04 29.08
29 INT351318 Binding of CYP2C19 and Cyp1a2 1 0.01 0.28 0.22 22.64
30 INT225800 Binding of Insr and Enpp1 1 0.05 0.67 0.04 21.40
31 INT332587 MND1 Positive_regulation of Binding of RAPH1 and MND1 1 0.00 2.21 0.03 16.84
32 INT344401 Agtr2 Positive_regulation of Gene_expression of Spp1 1 0.01 3.21 0 12.84
33 INT272012 Binding of TSC1 and Lsamp 1 0.03 2.1 0.08 10.20
34 INT238802 Binding of Ager and Renbp 6 0.02 6.46 0.22 9.88
35 INT270777 Binding of DMD and BPs 1 0.01 0.33 0.09 9.56
36 INT308660 Binding of Ager and App 1 0.08 1.22 0.12 9.04
37 INT308659 Binding of Ager and ecs 1 0.01 1.14 0.12 5.48
38 INT77646 Binding of Ngf and Ntrk1 23 0.40 7.85 9.26 5.00
39 INT106559 Binding of Bdnf and Ntrk2 23 0.43 11.09 7.33 5.00
40 INT88279 Ngf Positive_regulation of Ntrk1 5 0.76 3.06 5.23 5.00
41 INT240131 Binding of Crp and Nppb 7 0.07 11.53 2.12 5.00
42 INT66504 Binding of Agt and Agtr1a 8 0.39 3.78 1.78 5.00
43 INT198653 TNF Positive_regulation of MIF 1 0.15 3.81 1.55 5.00
44 INT70226 Binding of TAC1 and B3GAT1 4 0.24 4.5 1.26 5.00
45 INT225158 Binding of CDK2 and CDKN1A 7 0.30 3.26 1.02 5.00
46 INT195668 Binding of F2 and THBD 7 0.08 5.67 0.98 5.00
47 INT166983 Binding of HLA-B and HSPG2 4 0.08 4.66 0.88 5.00
48 INT209881 Binding of TNFRSF11B and TNFSF11 8 0.36 8.92 0.86 5.00
49 INT188531 Binding of TNF and PDXK 1 0.03 1.99 0.78 5.00
50 INT248271 IL6 Regulation of Gene_expression of Crp 3 0.27 1.7 0.73 5.00
51 INT165583 Binding of Bdnf and Ngf 3 0.33 0.81 0.69 5.00
52 INT28947 GH1 Positive_regulation of Gene_expression of IGF1 4 0.22 3.78 0.69 5.00
53 INT391 Binding of Agt and Ace 2 0.33 1.5 0.68 5.00
54 INT308668 Akt1 Positive_regulation of Nos3 3 0.05 4.61 0.65 5.00
55 INT330984 Negative_regulation of CYP2D6 Positive_regulation of Localization of CYP1A2 1 0.46 0 0.62 5.00
56 INT352496 AVP Regulation of Gene_expression of CRS 1 0.27 2.47 0.59 5.00
57 INT181619 ACE Positive_regulation of KNG1 1 0.33 0.97 0.58 5.00
58 INT178437 Mapk8 Positive_regulation of Jun 3 0.40 2.69 0.58 5.00
59 INT308656 Pik3r1 Positive_regulation of Nos3 1 0.02 1.8 0.5 5.00
60 INT314756 IL6 Positive_regulation of Gene_expression of Crp 2 0.13 4.58 0.48 5.00
61 INT197496 Binding of Apoe and Lrp1 4 0.22 2.32 0.46 5.00
62 INT225775 Enpp1 Positive_regulation of Ppi-rs 1 0.06 2.49 0.44 5.00
63 INT251015 OLR1 Regulation of Protein_catabolism of MMP3 1 0.03 0.91 0.4 5.00
64 INT209918 Positive_regulation of Nlrp3 Positive_regulation of Localization of Il1 1 0.42 1.06 0.4 5.00
65 INT171990 Binding of DMD and VDR 5 0.05 2.58 0.39 5.00
66 INT173977 Binding of TNF and Ighg1 1 0.03 0.28 0.39 5.00
67 INT188427 IL6 Positive_regulation of Pdxp 1 0.00 0.84 0.38 5.00
68 INT198652 F2 Positive_regulation of Gene_expression of CD36 1 0.03 1.32 0.37 5.00
69 INT78444 Binding of GH1 and IGF1 4 0.16 2.82 0.37 5.00
70 INT308653 Proc Regulation of Gene_expression of Mapk8 1 0.00 1.48 0.36 5.00
71 INT198647 TNF Positive_regulation of HIF1A 1 0.03 2.97 0.34 5.00
72 INT193492 Binding of Icam1 and Sele 1 0.06 1.05 0.34 5.00
73 INT198642 GPI Positive_regulation of TNF 1 0.03 0.98 0.33 5.00
74 INT308667 Binding of Chrm1 and Positive_regulation of Binding of App 1 0.04 1.14 0.32 5.00
75 INT311228 DPP4 Negative_regulation of Localization of GLP1R 1 0.31 1.25 0.32 5.00
76 INT229363 Negative_regulation of Binding of Agt and Agtr1a 2 0.22 0.9 0.32 5.00
77 INT255740 Pik3r1 Positive_regulation of Akt1 5 0.24 2.42 0.31 5.00
78 INT72445 Binding of AGT and REN 3 0.34 0.88 0.31 5.00
79 INT315369 Binding of IL6 and Crp 1 0.10 2.09 0.3 5.00
80 INT265826 Binding of ACE and SERPINE1 1 0.24 1.08 0.3 5.00
81 INT198640 TNF Positive_regulation of ISYNA1 1 0.04 1.07 0.29 5.00
82 INT225794 Il1 Negative_regulation of Gene_expression of Npp 1 0.02 0.99 0.28 5.00
83 INT225777 Il1 Negative_regulation of Npp 1 0.02 0.99 0.28 5.00
84 INT225776 Enpp1 Positive_regulation of Positive_regulation of Ppi-rs 1 0.08 1.67 0.28 5.00
85 INT225798 Il1 Negative_regulation of Gene_expression of Ppi-rs 1 0.01 1 0.28 5.00
86 INT225796 Il1 Negative_regulation of Ppi-rs 1 0.01 1 0.28 5.00
87 INT225784 Il1 Negative_regulation of Gene_expression of Enpp1 1 0.08 0.99 0.28 5.00
88 INT288911 AGT Positive_regulation of CYBB 3 0.07 2.96 0.28 5.00
89 INT265831 BGN Positive_regulation of ADCY1 1 0.01 0.41 0.27 5.00
90 INT329369 Jun Regulation of Gene_expression of Il12a 1 0.00 1.48 0.27 5.00
91 INT191718 Binding of FLT1 and VEGFA 35 0.50 12.18 0.27 5.00
92 INT265830 KNG1 Positive_regulation of Localization of BGN 1 0.02 0.33 0.27 5.00
93 INT263587 Pdia3 Negative_regulation of Binding of Esr1 1 0.07 1.86 0.26 5.00
94 INT198648 VCAM1 Positive_regulation of CADM1 1 0.00 1.1 0.25 5.00
95 INT308661 Akt1 Positive_regulation of Chuk 1 0.02 0.6 0.25 5.00
96 INT198644 TNF Positive_regulation of CADM1 1 0.02 1.07 0.24 5.00
97 INT198643 CD36 Positive_regulation of CADM1 1 0.01 1.07 0.24 5.00
98 INT329368 Ccl2 Negative_regulation of Jun 1 0.01 1.87 0.24 5.00
99 INT308670 Positive_regulation of CYBB Positive_regulation of Gene_expression of Ros1 1 0.00 0.68 0.23 5.00
100 INT265886 IGF1 Positive_regulation of AKT1 1 0.11 3.06 0.23 5.00
101 INT265828 ACE Regulation of Gene_expression of KNG1 1 0.32 0.83 0.22 5.00
102 INT354544 Avp Positive_regulation of ADCY1 1 0.24 2.23 0.22 5.00
103 INT255044 GLP1R Positive_regulation of Localization of INS 3 0.49 1.47 0.22 5.00
104 INT355503 Positive_regulation of SCN10A Positive_regulation of Localization of NPY 1 0.17 1.32 0.22 5.00
105 INT308650 Binding of nt and Ntrk2 1 0.01 0.41 0.21 5.00
106 INT313498 Binding of ALOX5 and SNRNP70 1 0.05 2.7 0.21 5.00
107 INT308654 Binding of Ngfr and Nts 1 0.06 0.39 0.21 5.00
108 INT229360 Agt Positive_regulation of Agtr1a 2 0.48 1.26 0.2 5.00
109 INT308645 Binding of Esr1 and Itpr3 1 0.00 0 0.2 5.00
110 INT308646 Car2 Regulation of Gene_expression of Ins1 1 0.00 0 0.19 5.00
111 INT308669 CREB1 Regulation of Gene_expression of Ins1 1 0.01 0 0.19 5.00
112 INT242037 Binding of CRP and SNRNP70 3 0.07 4.62 0.19 5.00
113 INT308657 Creb1 Regulation of Gene_expression of Ins1 1 0.01 0 0.19 5.00
114 INT225787 Ppi-rs Positive_regulation of Gene_expression of Ank 1 0.06 1.44 0.19 5.00
115 INT126944 Binding of PKD2 and Pkd1 2 0.08 2.09 0.19 5.00
116 INT258017 Binding of AGT and ANGPT2 3 0.11 2.35 0.19 5.00
117 INT330986 CYP2C9 Positive_regulation of Gene_expression of CYP3A4 1 0.39 0 0.18 5.00
118 INT330985 CYP2C9 Positive_regulation of Gene_expression of CYP2C19 1 0.34 0 0.18 5.00
119 INT280052 Negative_regulation of Dpp4 Positive_regulation of Zglp1 1 0.03 0.72 0.18 5.00
120 INT355504 ANGPT2 Positive_regulation of CYBB 1 0.01 0.81 0.18 5.00
121 INT198649 Binding of HIF1A and MIF 1 0.01 1.53 0.18 5.00
122 INT313554 Binding of ALOX5 and Cor 1 0.02 2.47 0.17 5.00
123 INT252646 Binding of C6orf25 and SYT16 1 0.00 0.51 0.17 5.00
124 INT265827 ACE Negative_regulation of ANGPT2 1 0.09 0.59 0.17 5.00
125 INT311226 DPP4 Negative_regulation of GLP1R 1 0.31 0.65 0.16 5.00
126 INT265892 IGF1 Positive_regulation of PIK3CG 1 0.18 1.96 0.16 5.00
127 INT311227 INS Negative_regulation of HBA1 1 0.01 0.52 0.16 5.00
128 INT125770 GLP1R Negative_regulation of Localization of GCG 2 0.29 0.65 0.16 5.00
129 INT308551 Binding of HP and VPS45 1 0.04 0.44 0.15 5.00
130 INT240768 Binding of F2 and F13A1 1 0.07 2.25 0.15 5.00
131 INT198638 GPI Positive_regulation of Gene_expression of TNF 1 0.03 1.44 0.15 5.00
132 INT194537 Binding of PAEP and Uox 1 0.10 1.12 0.14 5.00
133 INT225778 Igf1 Negative_regulation of Positive_regulation of Ppi-rs 1 0.01 0.82 0.14 5.00
134 INT225783 Enpp1 Regulation of Ppi-rs 1 0.07 0.68 0.13 5.00
135 INT329371 IL8 Negative_regulation of Jun 1 0.00 0.95 0.13 5.00
136 INT258016 AGTR1 Positive_regulation of EGFR 1 0.15 1.24 0.13 5.00
137 INT198671 HIF1A Regulation of Positive_regulation of Epo 1 0.00 1.37 0.13 5.00
138 INT308647 Ager Positive_regulation of Gene_expression of Bace1 1 0.09 1.01 0.12 5.00
139 INT229359 Agt Positive_regulation of Binding of Agtr1a 1 0.25 0.9 0.12 5.00
140 INT308651 Binding of Igf1 and Ins1 1 0.02 0.22 0.11 5.00
141 INT220905 Cfb Positive_regulation of C3 1 0.06 0.91 0.11 5.00
142 INT225785 Enpp3 Regulation of Ppi-rs 1 0.00 0.69 0.11 5.00
143 INT352497 AGT Positive_regulation of Binding of CRS 1 0.14 0.87 0.11 5.00
144 INT229364 Ace Positive_regulation of Protein_catabolism of KNG1 1 0.02 0.86 0.11 5.00
145 INT265888 BCL2 Regulation of Gene_expression of BAD 1 0.04 1.08 0.1 5.00
146 INT265890 BCL2 Regulation of Gene_expression of BAX 1 0.04 1.08 0.1 5.00
147 INT258014 Binding of ANGPT2 and RASGRP1 1 0.00 1.58 0.1 5.00
148 INT265889 BAX Regulation of Gene_expression of BAD 1 0.06 1.08 0.1 5.00
149 INT313505 Binding of SNRNP70 and CXADRP1 1 0.00 1.15 0.1 5.00
150 INT280053 Negative_regulation of Dpp4 Negative_regulation of Protein_catabolism of Zglp1 1 0.02 0.71 0.1 5.00
151 INT272006 Binding of YWHAQ and Tsc2 1 0.27 0.39 0.1 5.00
152 INT199436 Binding of Capns1 and Cysltr1 1 0.00 0.79 0.1 5.00
153 INT258018 Binding of AGT and RASGRP1 1 0.00 1.59 0.1 5.00
154 INT164925 GIP Positive_regulation of Localization of INS 2 0.59 0.86 0.09 5.00
155 INT265887 IGF1 Negative_regulation of BCL2 1 0.09 1.02 0.09 5.00
156 INT308662 Binding of Esr1 and Fdft1 1 0.00 0.05 0.09 5.00
157 INT239643 Binding of BCL2 and BCL2L11 3 0.16 2.26 0.09 5.00
158 INT265878 IGF1 Negative_regulation of Binding of BCL2 and BCL2L11 1 0.03 1.03 0.09 5.00
159 INT295005 Binding of TNFRSF11A and Tnfsf11 3 0.20 2.02 0.09 5.00
160 INT265829 ACE Positive_regulation of Protein_catabolism of KNG1 1 0.33 0.73 0.09 5.00
161 INT308666 Binding of Lrp1 and Chol1 1 0.10 0.69 0.09 5.00
162 INT313503 Binding of ALOX5AP and CXADRP1 1 0.01 1.51 0.08 5.00
163 INT262714 ACOT1 Positive_regulation of Negative_regulation of ACHE 1 0.06 1.41 0.08 5.00
164 INT300246 Binding of ABCB6 and HSR 1 0.11 1.86 0.08 5.00
165 INT220697 Binding of CHRNE and DBP 1 0.02 1.15 0.08 5.00
166 INT147774 Binding of HLA-B and ABCB6 2 0.40 1.03 0.08 5.00
167 INT267969 Binding of AGT and TRPV1 1 0.00 0.44 0.08 5.00
168 INT267970 Negative_regulation of Binding of AGT and TRPV1 1 0.00 0.44 0.08 5.00
169 INT313509 Binding of ALOX5 and SP1 1 0.07 1.51 0.08 5.00
170 INT205119 Binding of HIVEP1 and GREM1 1 0.00 2.24 0.08 5.00
171 INT310201 Binding of F12 and Chdh 1 0.04 1.06 0.08 5.00
172 INT295003 Binding of Tnfrsf11b and Tnfsf11 3 0.22 1.85 0.08 5.00
173 INT336341 Binding of RTCA and ELOVL1 1 0.02 2.15 0.07 5.00
174 INT308655 Binding of Lrp1 and Gopc 1 0.01 0.49 0.07 5.00
175 INT265883 IGF1 Positive_regulation of Transcription of FOXO1 1 0.17 1.14 0.07 5.00
176 INT258021 Positive_regulation of Binding of CDK2 and CDKN1A 1 0.11 0.84 0.07 5.00
177 INT265882 IGF1 Positive_regulation of Transcription of AKT1 1 0.08 1.13 0.07 5.00
178 INT272003 Binding of Tsc2 and Tsc1 1 0.18 1.1 0.07 5.00
179 INT265877 IGF1 Regulation of Binding of GH1 and IGF1 1 0.03 0.47 0.07 5.00
180 INT308665 Binding of Apoe and Gopc 1 0.02 0.49 0.07 5.00
181 INT308663 Apoe Regulation of Car2 1 0.02 0.44 0.07 5.00
182 INT225781 Ppi-rs Positive_regulation of Gene_expression of Spp1 1 0.03 1 0.07 5.00
183 INT265893 BAD Regulation of FOXO1 1 0.03 1.08 0.06 5.00
184 INT311225 GLP1R Positive_regulation of Gene_expression of INS 1 0.49 0.33 0.06 5.00
185 INT313506 Binding of ICAM1 and SNRNP70 1 0.02 1.08 0.06 5.00
186 INT225793 Ank Positive_regulation of Ppi-rs 1 0.06 1.77 0.06 5.00
187 INT224922 Binding of FAP and TARM1 1 0.06 1.4 0.06 5.00
188 INT220698 Binding of CHRNE and SFTPA1 1 0.01 0.75 0.06 5.00
189 INT220903 Regulation of Binding of Crp and Cd40 1 0.05 0.37 0.05 5.00
190 INT220906 Binding of Crp and Cd40 1 0.04 0.37 0.05 5.00
191 INT225799 Il1 Regulation of Ppi-rs 1 0.01 0.44 0.05 5.00
192 INT258015 Binding of ANGPT2 and REN 1 0.01 0.59 0.05 5.00
193 INT225779 Il1 Regulation of Npp 1 0.03 0.43 0.05 5.00
194 INT225790 Il1 Regulation of Gene_expression of Enpp1 1 0.07 0.43 0.05 5.00
195 INT225786 Enpp3 Positive_regulation of Ppi-rs 1 0.00 0.32 0.05 5.00
196 INT225780 Il1 Regulation of Gene_expression of Npp 1 0.03 0.43 0.05 5.00
197 INT280057 Zglp1 Positive_regulation of Transcription of INS 1 0.04 0.52 0.05 5.00
198 INT225806 Il1 Regulation of ALPI 1 0.00 0.44 0.05 5.00
199 INT321891 Dkk1 Negative_regulation of Wnt2 1 0.12 0.94 0.05 5.00
200 INT313504 Binding of ALOX5AP and SNRNP70 1 0.04 0.5 0.05 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Renal Insufficiency. They are ordered first by their pain relevance and then by number of times they were reported in Renal Insufficiency. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT23598 Binding of SCN5A 32 0.40 16 5.35 100.00
2 INT209072 Positive_regulation of Positive_regulation of CHGA 1 0.45 0.82 0.12 99.90
3 INT122902 Positive_regulation of Gene_expression of Spp1 54 0.70 56.3 6.33 99.88
4 INT3361 Positive_regulation of Esr1 273 0.69 208.53 44.81 99.88
5 INT184625 Localization of Skap2 4 0.62 0.5 0.03 99.84
6 INT18898 Positive_regulation of CHGA 38 0.67 28.99 4.86 99.78
7 INT846 Positive_regulation of B2M 42 0.70 29.78 8.06 99.72
8 INT122901 Positive_regulation of Spp1 67 0.67 58.03 7.49 99.70
9 INT1126 Negative_regulation of CD79A 46 0.59 31.07 6 99.50
10 INT132036 Negative_regulation of DPP4 126 0.59 63.24 9.51 99.40
11 INT118835 Positive_regulation of Vegfa 18 0.59 11.2 3.91 99.36
12 INT3526 Regulation of Rnase1 2 0.54 1.7 0.21 99.36
13 INT9832 Gene_expression of Shbg 96 0.75 56.71 12.19 99.32
14 INT110427 Gene_expression of Spp1 199 0.78 176.11 23.31 99.30
15 INT5940 Negative_regulation of Avp 236 0.59 67.86 101.2 99.30
16 INT70050 Negative_regulation of IL10 56 0.58 37.45 12.39 99.28
17 INT224366 Gene_expression of Ager 111 0.77 125.37 8.49 99.16
18 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 99.16
19 INT1533 Negative_regulation of AGT 105 0.42 46.54 16.92 99.16
20 INT86437 Binding of IL6 154 0.48 121.22 29.3 99.12
21 INT21103 Gene_expression of Dbp 48 0.61 22.6 5.59 99.00
22 INT214 Localization of AVP 370 0.81 208.51 91.09 98.92
23 INT11159 Gene_expression of EGFR 698 0.78 548.93 25.69 98.88
24 INT2451 Positive_regulation of Avp 355 0.70 102.66 147.69 98.76
25 INT24149 Gene_expression of BPHL 58 0.59 93.54 2.91 98.68
26 INT126575 Negative_regulation of Ppi-rs 21 0.14 12.94 3.2 98.64
27 INT6906 Negative_regulation of SCN5A 64 0.43 20.64 7.3 98.62
28 INT45110 Negative_regulation of Marco 1 0.07 0.17 0.09 98.46
29 INT232663 Positive_regulation of CCT6A 1 0.13 3.08 5.27 98.00
30 INT224428 Positive_regulation of Localization of BGLAP 5 0.30 2.34 0.44 97.88
31 INT1361 Negative_regulation of Gnrhr 118 0.58 57.77 35.54 97.60
32 INT144068 Binding of Nsf 9 0.48 7.67 3.16 97.48
33 INT172328 Negative_regulation of Phl1 1 0.03 61.51 0.97 97.36
34 INT3913 Positive_regulation of ABAT 47 0.69 22.73 33.4 97.36
35 INT68260 Localization of BGLAP 34 0.78 16.04 4.63 97.36
36 INT84546 Positive_regulation of Ppara 481 0.70 334.21 83.45 97.24
37 INT57721 Localization of CCT6A 2 0.16 3.12 5.88 97.24
38 INT112458 Localization of Selenbp2 4 0.04 1.1 4.74 97.24
39 INT130014 Positive_regulation of BMP2 11 0.66 5.34 1.42 97.20
40 INT2393 Positive_regulation of Mb 174 0.69 93.59 26.79 97.12
41 INT84598 Regulation of Aqp2 13 0.45 4.28 0.86 96.94
42 INT121834 Gene_expression of IAPP 24 0.66 20.96 0.26 96.88
43 INT1214 Gene_expression of PGE 70 0.72 29.07 16.22 96.80
44 INT34085 Negative_regulation of Gene_expression of PGE 16 0.35 4.9 3.76 96.80
45 INT22454 Regulation of Crp 213 0.62 160.67 49.24 96.72
46 INT573 Negative_regulation of C3 60 0.59 41.37 7.78 96.72
47 INT11679 Negative_regulation of F13A1 55 0.54 33.69 9.43 96.72
48 INT49783 Negative_regulation of Cyp1a1 3 0.37 0.63 1.3 96.40
49 INT91647 Gene_expression of PDXK 2 0.49 7.71 2.82 96.16
50 INT176528 Regulation of Spp1 9 0.45 9.05 0.77 95.96
51 INT1150 Gene_expression of ecs 42 0.59 29.38 7.73 95.80
52 INT135056 Positive_regulation of MTSS1 1 0.21 0.69 0 95.80
53 INT118565 Gene_expression of Ddit3 35 0.75 23.62 4.32 95.36
54 INT141166 Positive_regulation of Gene_expression of Ddit3 15 0.56 10.32 1.92 95.36
55 INT257453 Positive_regulation of USE1 12 0.20 6.7 0.94 95.32
56 INT9292 Positive_regulation of SGCG 93 0.67 35.13 23.48 95.32
57 INT177975 Positive_regulation of TNXA 1 0.01 1.22 0.07 95.20
58 INT2630 Positive_regulation of Shbg 134 0.70 65.26 15.19 95.12
59 INT7678 Localization of Alb 142 0.81 80.93 22.49 94.96
60 INT93490 Gene_expression of GPM6A 14 0.69 3.14 9.08 94.92
61 INT232661 Negative_regulation of Gene_expression of GPM6A 1 0.02 0.81 1.2 94.92
62 INT47939 Gene_expression of Selp 171 0.76 87.54 39.03 94.84
63 INT51458 Negative_regulation of Gene_expression of Selp 29 0.57 12.64 8.1 94.84
64 INT10893 Binding of VWF 27 0.47 25.02 2.82 94.84
65 INT1179 Negative_regulation of Ace 157 0.59 67.03 30.46 94.76
66 INT194520 Gene_expression of Uox 8 0.60 3.72 0.25 94.60
67 INT37037 Positive_regulation of ANTXR2 6 0.50 5.75 1.56 94.28
68 INT8539 Negative_regulation of Serpina1a 21 0.58 12.65 3.39 94.24
69 INT170335 Gene_expression of INCENP 176 0.54 91.62 15.31 94.16
70 INT95369 Positive_regulation of Gene_expression of NOS2 36 0.55 25.09 11.37 94.12
71 INT703 Positive_regulation of Pth 177 0.70 127.09 27.26 93.96
72 INT66401 Positive_regulation of Renf1 2 0.01 2.21 0.85 93.92
73 INT137153 Positive_regulation of VIS1 2 0.04 1.52 0.31 93.88
74 INT660 Negative_regulation of REN 194 0.59 82.06 29.46 93.36
75 INT328097 Positive_regulation of MBOAT7 1 0.02 3.57 0.38 93.36
76 INT76315 Gene_expression of Myog 15 0.41 6.79 0.6 93.28
77 INT236867 Gene_expression of AURKC 6 0.55 31.96 1.86 93.24
78 INT2774 Binding of Crp 241 0.48 195.89 44.39 93.20
79 INT39518 Negative_regulation of HBN1 66 0.09 37.54 2.58 93.08
80 INT68725 Regulation of Cyp11a1 6 0.19 2.62 0.44 93.04
81 INT42038 Localization of ACE 26 0.80 8.88 7.06 93.04
82 INT126577 Gene_expression of Ppi-rs 25 0.14 19.1 2.74 93.00
83 INT94772 Gene_expression of Cdkn2a 14 0.75 8.25 2.04 93.00
84 INT236873 Positive_regulation of Localization of AURKC 1 0.17 1.43 0 92.88
85 INT236866 Localization of AURKC 2 0.61 2.22 0 92.88
86 INT168262 Positive_regulation of Gene_expression of BPHL 10 0.24 10.72 0.83 92.80
87 INT28325 Negative_regulation of Tst 13 0.51 12.41 3.16 92.64
88 INT47343 Positive_regulation of Rnase1 6 0.65 4.66 1.01 92.60
89 INT17399 Positive_regulation of Positive_regulation of REN 13 0.69 7.05 1.9 92.56
90 INT17565 Regulation of Gpt 85 0.60 43.64 13.68 92.48
91 INT9852 Positive_regulation of Gpt 563 0.70 364.64 146.82 92.48
92 INT106482 Negative_regulation of Gene_expression of Epo 3 0.07 10.96 0.31 92.40
93 INT2843 Gene_expression of Epo 100 0.78 62.01 14.66 92.40
94 INT110039 Positive_regulation of Nppb 38 0.53 34.54 2.88 92.16
95 INT7232 Regulation of Negative_regulation of Lhb 9 0.45 3.63 3.29 92.16
96 INT306408 Regulation of Gene_expression of Tst 1 0.05 1.69 0.11 92.16
97 INT64468 Positive_regulation of Gene_expression of Prtn3 1 0.00 2.33 0.29 92.16
98 INT375 Positive_regulation of REN 293 0.70 152.46 47.55 92.08
99 INT64161 Positive_regulation of Prkca 213 0.70 85.06 129.91 92.00
100 INT155 Positive_regulation of Prl 1233 0.70 317.93 457.82 91.92
101 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 91.88
102 INT3952 Negative_regulation of ALB 116 0.59 72.18 18.35 91.84
103 INT79060 Gene_expression of NOS2 116 0.78 69.25 34.84 91.80
104 INT14184 Positive_regulation of CPB1 23 0.55 14.38 1.73 91.72
105 INT14186 Positive_regulation of Gene_expression of CPB1 2 0.39 3.46 0.42 91.72
106 INT27774 Gene_expression of Tst 13 0.68 12.86 4.83 91.68
107 INT236877 Negative_regulation of Gene_expression of BPHL 12 0.32 16.43 0.56 91.68
108 INT57147 Binding of ANIB1 3 0.31 1.65 0.44 91.60
109 INT5660 Binding of Oprd1 477 0.48 71.86 342.06 91.52
110 INT724 Negative_regulation of Alb 151 0.59 93.57 29.65 91.52
111 INT14182 Gene_expression of CPB1 26 0.67 10.06 1.9 91.36
112 INT166482 Negative_regulation of AKR1A1 5 0.15 2.51 1.07 91.32
113 INT267901 Regulation of Negative_regulation of AKR1A1 1 0.07 1.45 0.17 91.32
114 INT83995 Positive_regulation of Gene_expression of ACE 8 0.68 8.09 0.82 91.24
115 INT20665 Gene_expression of ACE 87 0.78 51.71 14.19 91.24
116 INT166010 Positive_regulation of Nsf 2 0.38 1.76 0.72 91.12
117 INT88571 Positive_regulation of Tcas1 4 0.34 2.08 4.42 91.04
118 INT4420 Positive_regulation of GOT1 103 0.64 88.4 18.38 90.96
119 INT130672 Binding of Ugt2b7 2 0.22 0.38 2.71 90.96
120 INT10369 Positive_regulation of Spic 4 0.03 1.99 1.54 90.92
121 INT13085 Positive_regulation of ACE 50 0.70 44.2 8.31 90.84
122 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 90.76
123 INT157921 Gene_expression of Nsf 3 0.58 2.31 1.09 90.56
124 INT2262 Negative_regulation of Lhb 142 0.59 25.47 44.81 90.04
125 INT29424 Negative_regulation of Positive_regulation of Lhb 21 0.56 4.58 4.03 90.04
126 INT11340 Positive_regulation of SLC17A5 120 0.67 113.52 14.5 90.00
127 INT28308 Localization of SLC17A5 10 0.73 6.77 0.7 90.00
128 INT37122 Gene_expression of Prtn3 3 0.60 3.65 1.04 89.88
129 INT15516 Gene_expression of Crp 711 0.77 615.33 173.09 89.76
130 INT52180 Binding of Aes 38 0.42 23.16 6.7 89.64
131 INT5128 Positive_regulation of Lhb 232 0.69 44.23 71.26 89.52
132 INT194521 Negative_regulation of Uox 7 0.52 4.93 0.41 89.52
133 INT16166 Positive_regulation of DMD 348 0.67 133.22 15.06 89.40
134 INT173940 Positive_regulation of Negative_regulation of DMD 8 0.59 2.97 0.36 89.40
135 INT211066 Negative_regulation of Positive_regulation of DMD 5 0.16 2.56 0.14 89.40
136 INT2391 Negative_regulation of PTGS1 501 0.59 207.62 205.6 89.32
137 INT1878 Binding of HLA-B 440 0.48 321.16 127.36 89.28
138 INT240359 Binding of Tnc 2 0.35 11.67 1.48 89.24
139 INT9234 Negative_regulation of Gene_expression of IL6 171 0.59 101.61 53.15 89.20
140 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 88.92
141 INT16167 Negative_regulation of DMD 186 0.57 108.71 15.25 88.88
142 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 88.64
143 INT67423 Regulation of Gene_expression of Selp 16 0.60 7.4 3.68 88.44
144 INT80086 Regulation of Gene_expression of PLEK 5 0.60 2.79 1.29 88.44
145 INT115613 Regulation of Gene_expression of ITGA2B 3 0.44 1.43 0.8 88.44
146 INT387 Regulation of Ace 18 0.45 5.24 4.24 88.20
147 INT50405 Negative_regulation of CYP3A4 238 0.59 53.65 51.51 87.84
148 INT1724 Negative_regulation of ACE 437 0.59 315.64 74.48 87.76
149 INT180338 Binding of Cyp2d4 12 0.47 6.87 4.09 87.68
150 INT346565 Positive_regulation of Sh3gl3 1 0.26 2.93 0.42 87.52
151 INT291026 Gene_expression of NSF 1 0.53 4.05 0.91 87.44
152 INT84264 Regulation of NPPB 22 0.61 21.18 1.94 87.20
153 INT10207 Gene_expression of PADI4 22 0.75 23.49 1.74 87.12
154 INT4403 Binding of CYP2B6 113 0.48 21.17 33.83 87.04
155 INT102355 Gene_expression of HSP90AA1 8 0.51 5.2 0.12 86.92
156 INT812 Localization of INS 1026 0.81 515.6 145.31 86.88
157 INT178941 Transcription of Sdc1 1 0.67 0.92 0 86.64
158 INT63839 Binding of CRS 31 0.41 34.05 4.7 86.28
159 INT14185 Regulation of CPB1 9 0.35 5.88 0.93 86.28
160 INT33739 Gene_expression of ITGA2B 25 0.75 8.19 3.6 86.08
161 INT12135 Gene_expression of PLEK 62 0.75 34.13 12.47 86.08
162 INT16449 Binding of IGHG3 67 0.48 39.55 10.59 85.72
163 INT43907 Binding of CD79A 28 0.48 28.11 3.04 85.72
164 INT65889 Gene_expression of RETNLB 73 0.34 60.98 38.3 85.68
165 INT327486 Binding of Dpa 1 0.02 1.74 0 85.44
166 INT1118 Gene_expression of C6orf25 73 0.77 47.24 9.1 85.32
167 INT47651 Gene_expression of DERL2 7 0.68 7.85 0.38 85.20
168 INT744 Positive_regulation of PTH 130 0.70 95.02 11.7 85.12
169 INT322090 Positive_regulation of Cd244 1 0.20 0.49 0.04 85.08
170 INT155889 Binding of Nps 22 0.42 9.79 2.6 84.92
171 INT169301 Phosphorylation of GRAP2 6 0.21 2.89 0.74 84.88
172 INT109925 Gene_expression of RPE 11 0.65 12.46 0.68 84.76
173 INT220839 Gene_expression of Cd244 7 0.29 3.2 0.19 84.44
174 INT57562 Gene_expression of GLA 52 0.77 24.62 6.14 84.32
175 INT15654 Gene_expression of Tg 22 0.66 12.2 2.36 84.24
176 INT68758 Positive_regulation of Ros1 125 0.46 82.72 25.27 84.16
177 INT61495 Positive_regulation of ICA1 8 0.49 4.19 3.87 83.76
178 INT61114 Gene_expression of Ppard 23 0.75 14.98 6.62 83.52
179 INT176208 Gene_expression of Nr1h2 27 0.59 22.75 3.84 83.52
180 INT131592 Gene_expression of NR1H3 5 0.24 2.37 0.77 83.52
181 INT36179 Regulation of GLA 11 0.44 6.56 1.12 83.44
182 INT210073 Regulation of Negative_regulation of SH3GL3 2 0.20 1.24 0.35 83.44
183 INT110110 Gene_expression of ACCS 85 0.58 75.88 10.2 83.28
184 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 83.04
185 INT9408 Positive_regulation of Crp 296 0.69 242.27 57.35 83.04
186 INT123701 Negative_regulation of VDR 61 0.59 48.94 9.67 82.96
187 INT262293 Gene_expression of CC2D1A 21 0.40 44.64 1.5 82.88
188 INT8112 Regulation of EPO 38 0.58 22.04 2.76 82.88
189 INT161027 Negative_regulation of RPE 7 0.37 4.34 0.38 82.76
190 INT94827 Gene_expression of HBS1L 24 0.67 26.11 1.61 82.68
191 INT3550 Negative_regulation of GLA 52 0.59 33.93 5.26 82.48
192 INT225753 Negative_regulation of Gene_expression of Ppi-rs 2 0.04 3.06 0.12 82.24
193 INT74687 Negative_regulation of STAB2 1 0.00 0.29 0.15 81.88
194 INT64888 Negative_regulation of HBM 52 0.16 34.33 5.45 81.76
195 INT15514 Negative_regulation of Crp 275 0.59 194.6 64.86 81.72
196 INT126576 Regulation of Ppi-rs 8 0.10 6.05 1.68 81.56
197 INT157 Positive_regulation of Localization of Prl 790 0.70 104.54 374.78 81.52
198 INT158 Localization of Prl 2431 0.81 378.96 952.2 81.52
199 INT74686 Negative_regulation of Calcr 1 0.05 0.14 0.06 81.44
200 INT1199 Positive_regulation of INS 579 0.70 399.64 50.43 81.36
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