D:Renal Tubular Acidosis

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Disease Term
Synonyms ACIDOSES RENAL TUBULAR, ACIDOSIS RENAL TUBULAR, ACIDOSIS RENAL TUBULAR TYPE I, ACIDOSIS RENAL TUBULAR TYPE II, Classic Distal Renal Tubular Acidosis, Distal Renal Tubular Acidosis, PROXIMAL RENAL TUBULAR ACIDOSIS, Renal Hyperchloraemic Acidosis, Renal Hyperchloremic Acidosis, Renal Tubular Acidoses, RENAL TUBULAR ACIDOSIS DISORDER
Documents 68
Hot Single Events 9
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Renal Tubular Acidosis. They are ordered first by their relevance to Renal Tubular Acidosis and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT354886 Thbs1 Regulation of Positive_regulation of Tgfb1 1 0.17 2.18 0.34 5.00
2 INT354888 Amy1 Regulation of Il10 1 0.02 1.41 0.13 5.00
3 INT354885 Amy1 Regulation of Gene_expression of Il10 1 0.03 1.41 0.13 5.00
4 INT212139 Slc4a3 Positive_regulation of Cl 1 0.07 0 0.12 5.00
5 INT212138 Slc4a3 Positive_regulation of Gene_expression of Cl 1 0.07 0 0.12 5.00
6 INT264148 Binding of CLCN7 and Ostm1 1 0.17 0.72 0.03 5.00
7 INT354890 Binding of TNF and Tnfsf13b 1 0.01 2.05 0 5.00
8 INT354887 Binding of Tnfsf13b and Gtf3a 1 0.01 2.05 0 5.00
9 INT264143 TCIRG1 Regulation of BSND 1 0.02 0.74 0 5.00
10 INT264144 CLCN7 Regulation of ADO 1 0.04 0.71 0 5.00
11 INT354889 Binding of TNF and Gtf3a 1 0.00 2.05 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Renal Tubular Acidosis. They are ordered first by their pain relevance and then by number of times they were reported in Renal Tubular Acidosis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT50446 Binding of MRGPRF 3 0.31 3.05 0.08 100.00
2 INT1536 Negative_regulation of NA 244 0.55 52.67 59.79 98.00
3 INT5743 Localization of NA 104 0.59 14.35 35.29 98.00
4 INT354868 Regulation of Cacna1s 1 0.03 2.02 0.37 97.72
5 INT4097 Localization of Pth 66 0.81 47.17 4.36 95.60
6 INT19395 Negative_regulation of Localization of Pth 11 0.58 10.16 0.55 95.60
7 INT467 Gene_expression of POMC 1048 0.78 332.8 394.16 87.68
8 INT267907 Negative_regulation of ADH1A 1 0.42 1.06 0.04 84.32
9 INT3559 Negative_regulation of Localization of Gnrhr 73 0.58 18.89 26.41 80.64
10 INT425 Localization of PRL 455 0.81 189.64 144.8 79.92
11 INT252 Localization of GH1 529 0.80 227.4 122.05 79.92
12 INT767 Localization of Gnrhr 565 0.80 106.68 214.57 79.92
13 INT915 Positive_regulation of PRL 342 0.70 141.96 104.31 75.00
14 INT914 Positive_regulation of GH1 292 0.69 100.7 84.91 75.00
15 INT957 Positive_regulation of GHRH 136 0.70 36.84 40.52 75.00
16 INT149125 Gene_expression of Slc4a3 25 0.78 3.45 2.41 74.80
17 INT6625 Negative_regulation of Pth 96 0.58 57.6 8.24 72.20
18 INT3364 Binding of SGCG 87 0.47 31.93 17.24 69.80
19 INT1129 Binding of Car2 69 0.35 14.01 9.2 69.28
20 INT9321 Transcription of Igf1 25 0.69 10.2 6.08 67.32
21 INT95512 Transcription of Ghr 24 0.69 3.1 4.12 66.40
22 INT90090 Gene_expression of ADO 4 0.58 1.41 0.42 52.48
23 INT264146 Gene_expression of MYO7A 1 0.05 1.36 0 52.08
24 INT9852 Positive_regulation of Gpt 563 0.70 364.64 146.82 46.12
25 INT71047 Gene_expression of CYP19A1 122 0.78 68.78 22.21 45.76
26 INT264145 Gene_expression of BSND 1 0.04 1.25 0 45.36
27 INT66193 Negative_regulation of Btd 3 0.59 3.39 0.32 43.72
28 INT703 Positive_regulation of Pth 177 0.70 127.09 27.26 42.32
29 INT39500 Positive_regulation of Positive_regulation of Pth 14 0.48 9.75 1.28 42.32
30 INT22083 Regulation of Pth 55 0.62 22.32 8.9 21.72
31 INT11650 Negative_regulation of Gpt 122 0.59 69.15 30.36 13.12
32 INT36770 Positive_regulation of Localization of Pth 14 0.70 10.42 0.46 6.24
33 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 5.00
34 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 5.00
35 INT16868 Gene_expression of Il6 807 0.78 499.48 256.57 5.00
36 INT738 Regulation of POMC 459 0.62 111.19 243.74 5.00
37 INT6354 Localization of Gabrg1 321 0.74 41.41 186.74 5.00
38 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 5.00
39 INT812 Localization of INS 1026 0.81 515.6 145.31 5.00
40 INT60694 Gene_expression of Il10 567 0.78 369.48 143.69 5.00
41 INT14843 Gene_expression of Gabrg1 301 0.77 62.63 139.16 5.00
42 INT695 Binding of POMC 304 0.48 56.66 126.85 5.00
43 INT6323 Positive_regulation of Gabrg1 213 0.70 45.08 124.34 5.00
44 INT8243 Positive_regulation of Il6 451 0.70 358.24 119.28 5.00
45 INT60691 Gene_expression of Il12a 331 0.78 208.03 75.96 5.00
46 INT11318 Gene_expression of Gtf3a 274 0.52 183.82 60.89 5.00
47 INT17564 Gene_expression of Gpt 322 0.75 208.51 60.36 5.00
48 INT5016 Negative_regulation of Crh 129 0.59 36.74 59.28 5.00
49 INT4509 Gene_expression of IgG 426 0.76 293.69 56.64 5.00
50 INT63975 Positive_regulation of Il10 175 0.68 134.13 54.69 5.00
51 INT30170 Gene_expression of Car2 330 0.66 77.26 46.76 5.00
52 INT1322 Positive_regulation of Localization of INS 293 0.70 120.86 45.98 5.00
53 INT42980 Gene_expression of GAD1 139 0.69 94.77 45.11 5.00
54 INT60695 Positive_regulation of Gene_expression of Il10 154 0.70 120.28 43.07 5.00
55 INT3987 Positive_regulation of IGHE 316 0.70 283.2 40.16 5.00
56 INT6357 Positive_regulation of Localization of Gabrg1 53 0.41 7.03 39.21 5.00
57 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 5.00
58 INT16960 Gene_expression of Crp 166 0.76 116.21 34.07 5.00
59 INT10248 Gene_expression of KRT20 436 0.78 231.96 32.88 5.00
60 INT66200 Gene_expression of Gfap 215 0.78 88.04 28.25 5.00
61 INT6624 Gene_expression of Pth 135 0.76 110.27 27.54 5.00
62 INT20585 Gene_expression of Gfra1 39 0.77 26.94 26.69 5.00
63 INT93626 Gene_expression of Fasl 118 0.75 115.24 25.11 5.00
64 INT150022 Positive_regulation of Il17a 69 0.64 70.04 21.87 5.00
65 INT60690 Positive_regulation of Gene_expression of Il12a 69 0.63 41.41 20.85 5.00
66 INT49985 Transcription of Il6 62 0.72 40.13 20.29 5.00
67 INT23533 Gene_expression of CA2 110 0.75 30.81 19.4 5.00
68 INT33327 Positive_regulation of Gene_expression of Gabrg1 39 0.69 9.68 18.82 5.00
69 INT12922 Gene_expression of Atp9a 115 0.75 50.95 17.01 5.00
70 INT14587 Positive_regulation of Cl 44 0.20 20.37 16.72 5.00
71 INT22900 Positive_regulation of Cd4 126 0.67 82.77 16.43 5.00
72 INT9220 Gene_expression of Ighg1 125 0.77 85.74 15.92 5.00
73 INT6947 Negative_regulation of Gene_expression of POMC 37 0.59 10.32 14.14 5.00
74 INT17565 Regulation of Gpt 85 0.60 43.64 13.68 5.00
75 INT46619 Gene_expression of CSF1 80 0.73 36.63 12.94 5.00
76 INT22213 Localization of Gpt 52 0.78 34.05 12.94 5.00
77 INT2578 Binding of Ins1 74 0.48 33.57 12.92 5.00
78 INT11288 Negative_regulation of CRH 44 0.00 16.69 12.37 5.00
79 INT48203 Positive_regulation of Tgfb1 67 0.70 41.31 11.07 5.00
80 INT10009 Positive_regulation of TRH 31 0.67 8.94 11.03 5.00
81 INT17283 Positive_regulation of CSF1 37 0.59 24.16 10.01 5.00
82 INT17996 Binding of Crp 40 0.37 31.4 7.8 5.00
83 INT39516 Gene_expression of Alb 81 0.75 30.08 6.59 5.00
84 INT150023 Positive_regulation of Il23a 25 0.38 18.33 6.32 5.00
85 INT3835 Positive_regulation of su 10 0.62 4.04 6.19 5.00
86 INT39416 Gene_expression of Cd79a 81 0.64 45.17 6.08 5.00
87 INT16573 Regulation of Cl 18 0.07 8.69 6.03 5.00
88 INT38671 Positive_regulation of KRT20 62 0.53 40.17 5.6 5.00
89 INT48201 Localization of Tgfb1 27 0.59 13.65 5.54 5.00
90 INT30738 Negative_regulation of Gene_expression of ALB 32 0.59 19.01 5.04 5.00
91 INT296054 Positive_regulation of Il22 13 0.33 17.97 4.06 5.00
92 INT66924 Positive_regulation of Transcription of Il6 18 0.68 11.8 3.53 5.00
93 INT64766 Gene_expression of TWIST1 41 0.76 37.89 3.4 5.00
94 INT550 Negative_regulation of LDLR 66 0.43 44.71 3.04 5.00
95 INT130865 Positive_regulation of TNFSF11 29 0.69 12.82 2.99 5.00
96 INT38673 Negative_regulation of KRT20 38 0.42 22.49 2.77 5.00
97 INT48198 Binding of Tgfb1 29 0.47 19.59 2.46 5.00
98 INT91999 Transcription of Gfra1 10 0.67 4.67 2.45 5.00
99 INT35643 Positive_regulation of BPIFA4P 7 0.67 4.87 2.39 5.00
100 INT165841 Gene_expression of BPIFA4P 17 0.65 6.48 2.38 5.00
101 INT97152 Protein_catabolism of COL1A1 11 0.74 8.03 2.3 5.00
102 INT49250 Regulation of Atp6v0d2 5 0.08 1.54 2.04 5.00
103 INT48880 Positive_regulation of TWIST1 15 0.59 8.6 1.98 5.00
104 INT101432 Positive_regulation of Gene_expression of Atp9a 13 0.10 7.86 1.95 5.00
105 INT216848 Gene_expression of TCIRG1 8 0.52 2.59 1.95 5.00
106 INT212124 Gene_expression of Cl 18 0.11 6.72 1.93 5.00
107 INT28679 Gene_expression of Tnfsf13b 5 0.60 2.75 1.53 5.00
108 INT45075 Gene_expression of Sugt1 24 0.27 8.5 1.33 5.00
109 INT173578 Negative_regulation of CTSK 8 0.44 6.29 1.15 5.00
110 INT28680 Positive_regulation of Tnfsf13b 5 0.39 6.46 1.1 5.00
111 INT176609 Gene_expression of Dpep1 8 0.03 2.37 1.07 5.00
112 INT212125 Regulation of Gene_expression of Cl 2 0.06 1.88 1.05 5.00
113 INT183967 Positive_regulation of Btg3 9 0.58 9.04 1.03 5.00
114 INT46169 Transcription of IgG 14 0.67 7.71 1.01 5.00
115 INT106960 Gene_expression of Chrm3 15 0.69 6.29 0.96 5.00
116 INT44972 Negative_regulation of Gfra1 16 0.58 10.17 0.93 5.00
117 INT254253 Transcription of Ighm 5 0.45 3.6 0.81 5.00
118 INT212128 Binding of Cl 5 0.11 0.92 0.75 5.00
119 INT62067 Negative_regulation of Gene_expression of Pth 13 0.41 8.24 0.61 5.00
120 INT259408 Gene_expression of Atp6v0d2 5 0.09 2.01 0.54 5.00
121 INT226028 Gene_expression of Trove2 4 0.65 9.97 0.54 5.00
122 INT36686 Regulation of Tg 7 0.19 3.12 0.45 5.00
123 INT57643 Negative_regulation of Binding of Ins1 6 0.43 3.51 0.43 5.00
124 INT203726 Regulation of Thbs1 2 0.33 1.41 0.41 5.00
125 INT201347 Negative_regulation of Gene_expression of Chrm3 4 0.30 2.48 0.31 5.00
126 INT212132 Negative_regulation of Slc4a3 1 0.43 1.17 0.3 5.00
127 INT212127 Positive_regulation of Gene_expression of Slc4a3 1 0.50 0.93 0.23 5.00
128 INT210218 Localization of Tnfsf13b 2 0.40 4.76 0.22 5.00
129 INT41673 Gene_expression of Amy1 2 0.30 2.41 0.21 5.00
130 INT326369 Gene_expression of Cntn2 2 0.25 1.34 0.2 5.00
131 INT315025 Gene_expression of Cacna1s 3 0.48 2.3 0.18 5.00
132 INT212136 Positive_regulation of Slc4a3 1 0.70 0.54 0.17 5.00
133 INT354866 Regulation of Xltr1 1 0.02 1.75 0.16 5.00
134 INT354859 Localization of Cacna1s 1 0.05 3.15 0.15 5.00
135 INT212129 Transcription of Slc4a3 1 0.69 0.07 0.13 5.00
136 INT212135 Localization of Slc4a3 2 0.73 0.35 0.13 5.00
137 INT212131 Positive_regulation of Gene_expression of Cl 4 0.08 0.88 0.12 5.00
138 INT212130 Gene_expression of Vsx1 2 0.61 0.1 0.1 5.00
139 INT239218 Positive_regulation of Cacna1s 2 0.04 2.21 0.1 5.00
140 INT188168 Binding of Slc4a3 4 0.47 1.06 0.07 5.00
141 INT239221 Negative_regulation of Cacna1s 4 0.04 2.24 0.07 5.00
142 INT354869 Gene_expression of Klk13 1 0.42 1.72 0.07 5.00
143 INT354867 Positive_regulation of Gene_expression of Klk13 1 0.38 1.72 0.07 5.00
144 INT212140 Gene_expression of CA14 1 0.11 1.66 0.06 5.00
145 INT212126 Gene_expression of Slc4a4 7 0.55 0.19 0.06 5.00
146 INT354856 Regulation of Cyp19a1 1 0.37 1.36 0.06 5.00
147 INT214037 Positive_regulation of Positive_regulation of BPIFA4P 2 0.11 1.36 0.05 5.00
148 INT346335 Positive_regulation of Negative_regulation of Gfra1 1 0.02 1.47 0.04 5.00
149 INT354861 Negative_regulation of Gene_expression of Trove2 1 0.41 1.4 0.04 5.00
150 INT212137 Transcription of Slc4a4 1 0.55 0 0 5.00
151 INT346340 Regulation of Gene_expression of BPIFA4P 1 0.06 0.68 0 5.00
152 INT204574 Positive_regulation of Cat4 1 0.49 0 0 5.00
153 INT241132 Transcription of Cd79a 2 0.27 1.96 0 5.00
154 INT354863 Regulation of Localization of Cacna1s 1 0.03 2.08 0 5.00
155 INT264147 Gene_expression of CLCN7 1 0.35 0.73 0 5.00
156 INT354864 Positive_regulation of Localization of Tnfsf13b 1 0.16 4.03 0 5.00
157 INT212133 Positive_regulation of Slc4a4 1 0.40 0 0 5.00
158 INT212141 Positive_regulation of Gene_expression of CA14 1 0.08 0.32 0 5.00
159 INT212134 Regulation of Slc4a3 1 0.62 0.34 0 5.00
160 INT204573 Transcription of su 1 0.02 0.2 0 5.00
161 INT212142 Binding of CA14 1 0.08 0 0 5.00
162 INT149440 Negative_regulation of TWIST1 4 0.41 1.5 0 5.00
163 INT204572 Gene_expression of Foxi1 1 0.58 0 0 5.00
164 INT204571 Transcription of Cat4 1 0.67 0.06 0 5.00
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