D:Reproductive System Disorders

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Disease Term
Synonyms Disorder Of Reproductive System, Genital Disorders, Reproductive System Disease, Reproductive Tract Disorder
Documents 8
Hot Single Events 9
Hot Interactions 3

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Reproductive System Disorders. They are ordered first by their relevance to Reproductive System Disorders and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT338190 Binding of PCa and VDR 1 0.00 0.84 0 97.90
2 INT338183 Binding of PCa and TFF3 1 0.01 0.85 0 97.90
3 INT338184 Binding of PCa and HPN 1 0.02 0.79 0 97.90
4 INT197317 Nr4a2 Regulation of Gene_expression of Th 1 0.03 0.07 0.12 27.20
5 INT209043 Binding of Fn1 and Slc11a1 3 0.03 1.91 0.78 5.00
6 INT147575 Binding of Ahr and Cyp1a1 2 0.15 0.15 0.54 5.00
7 INT226911 Slc11a1 Positive_regulation of Gene_expression of Il6 1 0.09 1.12 0.24 5.00
8 INT226902 Padi3 Regulation of Trp53 1 0.06 0.69 0.22 5.00
9 INT226903 Txnl1 Regulation of Ins1 1 0.01 0.59 0.19 5.00
10 INT226901 Slc11a1 Regulation of Hist1h3f 1 0.02 0.41 0.15 5.00
11 INT226907 Binding of E2f1 and Nfkb1 1 0.14 0.6 0.12 5.00
12 INT226904 Nfkb1 Regulation of Gene_expression of Vcam1 1 0.14 0.27 0.12 5.00
13 INT226899 Slc11a1 Positive_regulation of Localization of Gtf3a 1 0.00 0.54 0.11 5.00
14 INT226910 Slc11a1 Positive_regulation of Localization of Nfkb1 1 0.11 0.62 0.11 5.00
15 INT226912 Slc11a1 Positive_regulation of Localization of IL8 1 0.05 0.58 0.08 5.00
16 INT226906 Binding of Ido1 and Il6 1 0.07 0.67 0.08 5.00
17 INT226913 Slc11a1 Positive_regulation of Gene_expression of IL8 1 0.05 0.63 0.07 5.00
18 INT226897 Binding of Slc11a1 and Tg(CAG-EGFP)D4Nagy 1 0.01 0.17 0.04 5.00
19 INT226905 Slc11a1 Regulation of Nfkb1 1 0.04 0.41 0.03 5.00
20 INT197296 Ahr Regulation of Bhlha15 1 0.48 0.47 0.03 5.00
21 INT338198 SRC Positive_regulation of STAT3 1 0.11 0.34 0 5.00
22 INT338180 Binding of AR and STAT3 1 0.18 0.3 0 5.00
23 INT338191 CDCP1 Positive_regulation of HGFAC 1 0.00 0.4 0 5.00
24 INT226900 Binding of Mdk and Map3k8 1 0.05 0.14 0 5.00
25 INT197309 Ascl1 Regulation of Neurod1 1 0.01 0.13 0 5.00
26 INT197313 Atoh1 Regulation of Neurod1 1 0.01 0.13 0 5.00
27 INT338194 Regulation of VAV3 Regulation of AR 1 0.31 0.49 0 5.00
28 INT338189 SRC Positive_regulation of HGFAC 1 0.00 0.4 0 5.00
29 INT338179 EEF1D Regulation of CDCP1 1 0.00 1.43 0 5.00
30 INT197316 Hes1 Regulation of Atoh1 1 0.01 0.14 0 5.00
31 INT338197 CCND1 Negative_regulation of AR 1 0.24 0 0 5.00
32 INT338192 CDCP1 Positive_regulation of STAT3 1 0.00 0.34 0 5.00
33 INT197304 Ahr Regulation of Hes1 1 0.06 0.17 0 5.00
34 INT226896 Slc11a1 Positive_regulation of Binding of Nfkb1 1 0.11 0.08 0 5.00
35 INT338178 Binding of CDCP1 and CDCP1 Positive_regulation of SRC 1 0.00 0.31 0 5.00
36 INT197295 Positive_regulation of Binding of Ahr and Cyp1a1 1 0.20 0 0 5.00
37 INT338195 Binding of SRC and FIBP 1 0.00 0.31 0 5.00
38 INT338182 CDCP1 Positive_regulation of Phosphorylation of AR 1 0.01 0.29 0 5.00
39 INT338187 VAV3 Regulation of CDCP1 1 0.00 1.47 0 5.00
40 INT197315 Hes5 Regulation of Atoh1 1 0.00 0.14 0 5.00
41 INT197306 Atoh1 Regulation of Neurod6 1 0.00 0.13 0 5.00
42 INT226909 Positive_regulation of Binding of Nfkb1 and Slc11a1 1 0.07 0.18 0 5.00
43 INT197314 Hes5 Regulation of Ascl1 1 0.00 0.14 0 5.00
44 INT338196 Binding of SRC and CDCP1 1 0.00 0.31 0 5.00
45 INT226898 Binding of Nfkb1 and Slc11a1 1 0.06 0.2 0 5.00
46 INT226908 Binding of Nfkb1 and Map3k8 1 0.14 0.14 0 5.00
47 INT197310 Hes1 Regulation of Ascl1 1 0.01 0.14 0 5.00
48 INT197307 Ascl1 Regulation of Neurod6 1 0.00 0.13 0 5.00
49 INT338186 Binding of FIBP and CDCP1 1 0.00 0.31 0 5.00
50 INT338185 VAV3 Regulation of Positive_regulation of AR 1 0.19 0.49 0 5.00
51 INT338193 VAV3 Regulation of AR 1 0.31 0.49 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Reproductive System Disorders. They are ordered first by their pain relevance and then by number of times they were reported in Reproductive System Disorders. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT5206 Gene_expression of AR 316 0.78 113.83 27.29 99.56
2 INT90603 Positive_regulation of Ahr 103 0.69 58.65 7.73 97.36
3 INT19472 Gene_expression of Il1 554 0.76 419.75 175.35 95.80
4 INT52531 Gene_expression of Nfkb1 153 0.75 82.84 42.9 95.80
5 INT666 Gene_expression of Jun 124 0.78 54.61 33.67 95.80
6 INT109315 Gene_expression of Mapk8 70 0.78 45.46 11.65 95.80
7 INT11159 Gene_expression of EGFR 698 0.78 548.93 25.69 80.72
8 INT10115 Gene_expression of INSR 31 0.75 11.98 4.86 80.72
9 INT28300 Gene_expression of GHR 10 0.78 4.29 1.5 80.72
10 INT104979 Gene_expression of MITF 51 0.62 54.83 6.91 76.40
11 INT284938 Regulation of DNMT1 2 0.22 1.17 0.24 72.04
12 INT300944 Regulation of DNMT3A 1 0.21 0.91 0.24 71.76
13 INT46336 Regulation of DNMT3B 12 0.53 4.91 1.25 71.28
14 INT5131 Gene_expression of GNRH1 109 0.78 28.79 23.94 68.68
15 INT300943 Regulation of Localization of HOXA10 1 0.21 1.02 0.24 67.80
16 INT300941 Regulation of Localization of PGR 1 0.04 1.02 0.24 67.80
17 INT83236 Localization of PGR 14 0.73 8.26 2.23 67.80
18 INT194590 Localization of HOXA10 1 0.35 1.54 0.59 67.80
19 INT58602 Gene_expression of HMI 34 0.65 25.26 3.74 65.76
20 INT101189 Transcription of Gtf3a 49 0.17 24.39 7.93 61.08
21 INT196920 Transcription of E2f1 4 0.68 2.65 0.21 61.08
22 INT226861 Regulation of Transcription of Usf1 1 0.23 0.44 0.03 57.40
23 INT226877 Regulation of Transcription of Bmp5 1 0.20 0.44 0.03 57.40
24 INT226858 Regulation of Usf1 1 0.23 0.44 0.03 57.40
25 INT226884 Regulation of Bmp5 1 0.20 0.44 0.03 57.40
26 INT197289 Transcription of Nr4a2 1 0.06 0.06 0.12 56.72
27 INT271570 Gene_expression of MIR1-1 21 0.65 11.49 1.03 56.64
28 INT226862 Transcription of Bmp5 1 0.31 0.43 0 55.72
29 INT226857 Transcription of Usf1 1 0.35 0.43 0 55.72
30 INT197288 Regulation of Positive_regulation of Ahr 1 0.59 0.45 0.07 55.20
31 INT147572 Gene_expression of Ahr 73 0.75 38.99 3.15 49.60
32 INT197286 Positive_regulation of Gene_expression of Ahr 10 0.67 9.78 0.36 49.60
33 INT30817 Gene_expression of Th 142 0.76 33.56 38.12 48.72
34 INT102901 Regulation of Gene_expression of Th 12 0.60 2.42 3.22 42.24
35 INT109265 Transcription of Th 18 0.68 4.5 8.21 41.76
36 INT99628 Positive_regulation of Gene_expression of Cyp1a1 4 0.25 1.3 0.27 41.08
37 INT13674 Gene_expression of Cyp1a1 13 0.65 2.22 1.25 40.60
38 INT1703 Regulation of PCa 52 0.52 23.65 20.6 37.76
39 INT47207 Negative_regulation of Ahr 25 0.52 16.11 3.02 36.92
40 INT102200 Gene_expression of Nr4a2 9 0.72 3.69 1.28 31.84
41 INT186632 Regulation of TWIST1 4 0.37 5.28 0.14 29.76
42 INT44661 Regulation of Ahr 15 0.45 12.69 2.79 29.24
43 INT64766 Gene_expression of TWIST1 41 0.76 37.89 3.4 28.16
44 INT338236 Gene_expression of VAV3 1 0.63 8.45 0 27.12
45 INT189237 Gene_expression of DKK3 2 0.55 10.13 0.22 24.24
46 INT300353 Regulation of MIR1-1 6 0.12 3.49 0.16 13.84
47 INT148898 Negative_regulation of Gene_expression of Nr4a2 3 0.54 1.13 0.26 12.00
48 INT215202 Localization of Igfbp3 3 0.62 2.5 0.91 11.64
49 INT226865 Localization of Sema5a 1 0.39 0.06 0 11.64
50 INT184914 Negative_regulation of Gene_expression of Th 15 0.43 9.17 2.46 11.04
51 INT12720 Positive_regulation of Il1 246 0.70 195.97 72.05 6.28
52 INT6596 Positive_regulation of HLA-DRB1 33 0.61 27.01 7.26 6.28
53 INT132837 Positive_regulation of Csk 5 0.45 1.75 1.79 6.28
54 INT64685 Positive_regulation of Gzma 2 0.09 0.43 0.09 6.28
55 INT226860 Positive_regulation of Dnajc5 1 0.09 0.11 0 6.28
56 INT226888 Positive_regulation of Gbp2 1 0.13 0.11 0 6.28
57 INT226895 Positive_regulation of Faf1 1 0.08 0.11 0 6.28
58 INT226856 Positive_regulation of Arl6 1 0.09 0.06 0 6.28
59 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
60 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
61 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
62 INT5379 Gene_expression of Fos 656 0.78 255.5 292.54 5.00
63 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
64 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 5.00
65 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 5.00
66 INT6481 Binding of TNF 624 0.48 510.2 214.82 5.00
67 INT9660 Regulation of TNF 363 0.62 312.94 139.99 5.00
68 INT7533 Gene_expression of Tlr4 720 0.78 343.22 121.57 5.00
69 INT8243 Positive_regulation of Il6 451 0.70 358.24 119.28 5.00
70 INT85640 Gene_expression of Tg(CAG-EGFP)D4Nagy 1138 0.72 311.58 119.18 5.00
71 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61 5.00
72 INT12339 Localization of IL8 437 0.81 251.87 117.39 5.00
73 INT20374 Gene_expression of Il4 515 0.76 306.15 114.12 5.00
74 INT11051 Positive_regulation of Gene_expression of IL6 415 0.69 319.21 109.3 5.00
75 INT27096 Positive_regulation of Nfkb1 325 0.70 195.11 109.06 5.00
76 INT12082 Localization of IL6 365 0.81 241.78 105.78 5.00
77 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
78 INT11937 Localization of Il6 228 0.81 139.83 64.39 5.00
79 INT1951 Positive_regulation of Tlr4 345 0.70 176.99 62.42 5.00
80 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07 5.00
81 INT11318 Gene_expression of Gtf3a 274 0.52 183.82 60.89 5.00
82 INT69876 Negative_regulation of Nfkb1 147 0.58 89.81 55.5 5.00
83 INT62543 Gene_expression of Icam1 231 0.78 187.58 52.71 5.00
84 INT19775 Localization of Il1 183 0.78 145.5 50.91 5.00
85 INT83953 Gene_expression of Cxcl2 140 0.75 113.07 43.65 5.00
86 INT957 Positive_regulation of GHRH 136 0.70 36.84 40.52 5.00
87 INT1705 Gene_expression of pCA 126 0.65 88.65 34.81 5.00
88 INT104392 Gene_expression of Cxcl10 113 0.75 106.86 34.12 5.00
89 INT49214 Gene_expression of Cd4 269 0.78 154.22 34.05 5.00
90 INT114881 Gene_expression of Akt1 227 0.78 102.49 31.81 5.00
91 INT110020 Gene_expression of Mapk14 142 0.77 72.33 30.08 5.00
92 INT6660 Positive_regulation of Jun 148 0.69 67.58 29.73 5.00
93 INT8097 Gene_expression of EGF 122 0.77 75.94 28.47 5.00
94 INT48202 Gene_expression of Tgfb1 146 0.78 89.93 27.76 5.00
95 INT62710 Gene_expression of HGF 160 0.78 88.27 26.14 5.00
96 INT73670 Gene_expression of Vcam1 128 0.78 123.79 24.96 5.00
97 INT66758 Binding of Nfkb1 97 0.48 50.65 23.65 5.00
98 INT1704 Positive_regulation of PCa 68 0.59 34.92 23.36 5.00
99 INT71875 Localization of Nfkb1 92 0.78 48.13 22.94 5.00
100 INT955 Gene_expression of GHRH 126 0.78 59.91 20.74 5.00
101 INT85952 Positive_regulation of AR 168 0.67 64.36 20.66 5.00
102 INT24240 Positive_regulation of Th 60 0.70 9.92 20.18 5.00
103 INT7994 Gene_expression of Lta 113 0.67 69.81 19.59 5.00
104 INT101188 Gene_expression of Rela 81 0.56 23.43 19.15 5.00
105 INT2006 Gene_expression of fc 104 0.34 64.91 19.08 5.00
106 INT17313 Positive_regulation of HSPG2 57 0.67 55.78 16.65 5.00
107 INT28950 Positive_regulation of Gene_expression of IGF1 99 0.69 46.9 16.47 5.00
108 INT170308 Gene_expression of Ido1 159 0.75 69.51 15.98 5.00
109 INT65659 Positive_regulation of STAT3 132 0.70 69.56 15.95 5.00
110 INT171666 Regulation of GOPC 117 0.39 40.41 15.47 5.00
111 INT1706 Negative_regulation of PCa 33 0.47 10.7 15.27 5.00
112 INT26545 Gene_expression of Hras1 173 0.78 79.54 13.21 5.00
113 INT20381 Localization of Il2 71 0.77 34.23 13.03 5.00
114 INT27268 Localization of Gtf3a 71 0.21 56.93 12.51 5.00
115 INT170601 Positive_regulation of Gene_expression of GOPC 122 0.43 42.79 11.68 5.00
116 INT86729 Positive_regulation of CDCP1 37 0.07 18.74 10.76 5.00
117 INT80110 Regulation of Positive_regulation of TNF 34 0.44 25.79 9.78 5.00
118 INT2036 Localization of EGF 42 0.77 21.5 9.74 5.00
119 INT114874 Gene_expression of Stat3 78 0.76 53.99 9.49 5.00
120 INT35366 Binding of AR 87 0.47 30.52 8.9 5.00
121 INT178174 Gene_expression of Tnfsf10 78 0.76 56.83 8.64 5.00
122 INT34777 Localization of IGF1 82 0.80 42.68 8.62 5.00
123 INT156396 Localization of Tg(CAG-EGFP)D4Nagy 61 0.55 13.63 8.17 5.00
124 INT111533 Positive_regulation of Gene_expression of Nfkb1 27 0.52 17.32 7.89 5.00
125 INT175526 Phosphorylation of Gopc 73 0.53 21.08 7.86 5.00
126 INT39417 Gene_expression of Fcer2a 65 0.76 32.1 7.37 5.00
127 INT82610 Positive_regulation of SRC 53 0.67 26.89 7.27 5.00
128 INT55091 Positive_regulation of Mgst1 35 0.69 10.77 6.88 5.00
129 INT170381 Transcription of Gopc 59 0.60 15.96 6.82 5.00
130 INT160562 Localization of Cd4 49 0.71 27.58 6.78 5.00
131 INT74944 Positive_regulation of Gene_expression of HGF 31 0.70 17.69 6.68 5.00
132 INT84685 Regulation of BCL2 67 0.60 72.96 6.65 5.00
133 INT50387 Negative_regulation of AR 67 0.45 26.31 6.61 5.00
134 INT25385 Positive_regulation of Localization of Il2 17 0.45 9.53 6.45 5.00
135 INT86805 Localization of HGF 49 0.71 28.48 6.35 5.00
136 INT61258 Transcription of Nfkb1 24 0.67 10.89 6.32 5.00
137 INT11154 Binding of EGFR 149 0.48 96.23 6.29 5.00
138 INT88245 Gene_expression of Slc11a1 42 0.53 18.86 6.2 5.00
139 INT123551 Regulation of Mmp2 17 0.57 11.6 6 5.00
140 INT75501 Gene_expression of CCND1 90 0.76 60.86 5.93 5.00
141 INT185 Regulation of Cyp1a1 18 0.54 2.71 5.56 5.00
142 INT87211 Positive_regulation of Localization of Nfkb1 27 0.59 15.84 5.25 5.00
143 INT99549 Gene_expression of CDKN1B 30 0.75 17 5.15 5.00
144 INT99091 Regulation of AR 70 0.45 31.68 5.05 5.00
145 INT186 Positive_regulation of Cyp1a1 30 0.70 5 5.02 5.00
146 INT98453 Positive_regulation of Src 19 0.47 7.84 4.62 5.00
147 INT10754 Positive_regulation of Gene_expression of PCa 18 0.41 21.81 4.17 5.00
148 INT83035 Binding of INSR 16 0.47 9.29 4.11 5.00
149 INT224807 Gene_expression of Gria4 35 0.78 4.63 4.02 5.00
150 INT93110 Regulation of CDCP1 16 0.03 7.98 3.83 5.00
151 INT209018 Positive_regulation of Slc11a1 11 0.55 7.12 3.83 5.00
152 INT121818 Binding of STAT3 25 0.47 11.16 3.67 5.00
153 INT195527 Binding of Rela 17 0.25 4.42 3.56 5.00
154 INT67726 Gene_expression of Notch1 36 0.75 9.77 3.54 5.00
155 INT5204 Positive_regulation of Gene_expression of AR 60 0.67 23.54 3.53 5.00
156 INT8096 Positive_regulation of Gene_expression of EGF 21 0.69 13.43 3.47 5.00
157 INT60745 Gene_expression of Ltbr 10 0.61 7.86 3.21 5.00
158 INT100688 Gene_expression of SRC 28 0.75 15.51 3.08 5.00
159 INT78581 Positive_regulation of Binding of Nfkb1 13 0.66 7.37 2.79 5.00
160 INT90875 Negative_regulation of CCND1 31 0.42 26.22 2.66 5.00
161 INT83374 Gene_expression of FGF7 83 0.78 44.18 2.6 5.00
162 INT185927 Positive_regulation of Positive_regulation of AR 12 0.34 6.35 2.5 5.00
163 INT9905 Gene_expression of DECR1 11 0.75 2.49 2.43 5.00
164 INT209019 Localization of Slc11a1 12 0.33 4.33 2.33 5.00
165 INT89166 Transcription of Mgst1 6 0.72 2 2.27 5.00
166 INT17617 Gene_expression of ABL2 8 0.75 2.73 2.25 5.00
167 INT201652 Positive_regulation of Tnfsf10 26 0.68 26.79 2.14 5.00
168 INT96841 Regulation of Slc11a1 9 0.36 6.83 2.14 5.00
169 INT213788 Gene_expression of Tfeb 18 0.66 7.9 2.07 5.00
170 INT48880 Positive_regulation of TWIST1 15 0.59 8.6 1.98 5.00
171 INT56925 Negative_regulation of TSC1 54 0.52 63.39 1.87 5.00
172 INT226894 Negative_regulation of Tnfsf10 14 0.57 16.64 1.87 5.00
173 INT78665 Gene_expression of Irgm1 12 0.65 3.17 1.83 5.00
174 INT226868 Transcription of Map3k8 2 0.52 17.13 1.73 5.00
175 INT165617 Localization of STAT3 28 0.78 9.04 1.72 5.00
176 INT52530 Regulation of Gene_expression of Nfkb1 8 0.59 4.41 1.68 5.00
177 INT224643 Positive_regulation of Gene_expression of Tnfsf10 13 0.46 11.1 1.67 5.00
178 INT96842 Binding of Slc11a1 16 0.34 7.15 1.66 5.00
179 INT73674 Regulation of Gene_expression of Vcam1 9 0.33 11.23 1.64 5.00
180 INT954 Positive_regulation of Gene_expression of GHRH 18 0.50 7.6 1.63 5.00
181 INT10753 Regulation of Gene_expression of PCa 8 0.23 7.16 1.49 5.00
182 INT217825 Regulation of Gene_expression of MITF 3 0.00 5.2 1.47 5.00
183 INT116625 Phosphorylation of Nefh 13 0.79 5.94 1.4 5.00
184 INT213379 Phosphorylation of AR 6 0.63 2.03 1.21 5.00
185 INT138498 Gene_expression of ROBO1 2 0.45 1.76 1.18 5.00
186 INT180095 Gene_expression of Rock1 22 0.55 4.9 1.14 5.00
187 INT152225 Regulation of Positive_regulation of Tlr4 8 0.53 2.5 1.12 5.00
188 INT182454 Binding of Tg(CAG-EGFP)D4Nagy 28 0.29 3.29 1.11 5.00
189 INT118952 Gene_expression of Hist1h3f 13 0.21 3.58 1.05 5.00
190 INT45079 Binding of Ahr 21 0.44 10.07 1 5.00
191 INT234473 Gene_expression of HDAC4 8 0.18 6.28 0.99 5.00
192 INT141475 Negative_regulation of Gene_expression of TWIST1 5 0.41 3.94 0.97 5.00
193 INT184015 Positive_regulation of Stat5a 9 0.46 3.32 0.86 5.00
194 INT85135 Gene_expression of CDCP1 14 0.02 5.1 0.84 5.00
195 INT124092 Gene_expression of Myo1b 3 0.41 1.22 0.82 5.00
196 INT118004 Positive_regulation of Gene_expression of SRC 13 0.49 11.05 0.8 5.00
197 INT74019 Regulation of TSC1 27 0.35 23.61 0.79 5.00
198 INT114714 Binding of IGF1R 8 0.36 5.26 0.78 5.00
199 INT184484 Positive_regulation of Cdc42ep3 5 0.02 5.16 0.77 5.00
200 INT151010 Regulation of Gene_expression of Lta 5 0.18 2.44 0.74 5.00
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