D:Reprotox - General 2

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Disease Term
Synonyms Adnexal Enlargement, Alterations In Rate Strength Uterine Contractions During Labor, Altered Libido, Angrogen Like Effects, Apgar Score Low, Aspermia, Atrophy Of Endometrial Tissue, Azoospermy, Blighted Ovum, BREAST FEEDING DISORDER, Breast Malignant Neoplasm
Documents 3787
Hot Single Events 200
Hot Interactions 15

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Reprotox - General 2. They are ordered first by their relevance to Reprotox - General 2 and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT126791 RASL12 Positive_regulation of ADRA1D 1 0.24 2.62 0.22 100.00
2 INT126795 RASL12 Positive_regulation of Hal 1 0.01 2.62 0.22 100.00
3 INT214691 Binding of CGA and CGB 1 0.01 0.7 0.17 99.36
4 INT170447 Binding of Pax3 and Spr 1 0.01 0.1 5.37 98.32
5 INT277622 Esr1 Positive_regulation of Gene_expression of Cyp19a1 1 0.03 1.37 0 94.60
6 INT186247 CGA Regulation of Gene_expression of SOD1 1 0.01 0.35 0 92.40
7 INT246480 Binding of ALB and SHBG 2 0.14 1.45 0.03 92.28
8 INT171991 Binding of DMD and ERAL1 1 0.01 0.54 0 92.04
9 INT270355 Vcsa1 Positive_regulation of Negative_regulation of Mme 1 0.13 0.52 0.12 91.04
10 INT25248 GNRH1 Regulation of CGA 4 0.30 1.22 0.62 89.52
11 INT230455 FOXG1 Negative_regulation of HBS1L 1 0.02 1.73 0.18 88.64
12 INT269758 Negative_regulation of IGF1 Negative_regulation of Positive_regulation of IGFBP2 1 0.10 2.15 0.16 84.64
13 INT222299 Binding of CYP19A1 and AIS 2 0.25 1.65 0.31 83.68
14 INT43587 Binding of OPRD1 and Pah 1 0.00 0.08 0.43 83.28
15 INT209881 Binding of TNFRSF11B and TNFSF11 8 0.36 8.92 0.86 82.68
16 INT182636 Binding of TNFSF11 and TNFRSF11A 16 0.29 17.5 0.84 75.68
17 INT84867 Ptger1 Negative_regulation of SETD2 1 0.00 1.09 0.11 75.40
18 INT54584 GNRH1 Positive_regulation of FSHR 3 0.48 2.02 0.54 75.00
19 INT19633 GNRH1 Regulation of Localization of CGA 4 0.44 0.82 1.33 75.00
20 INT197651 TNF Regulation of PTH 1 0.05 1.67 0 74.16
21 INT197643 TNF Regulation of VDR 1 0.04 1.67 0 74.16
22 INT213933 AR Negative_regulation of Cyp19a1 1 0.07 0.79 0.07 71.88
23 INT315334 Binding of CYP3A4 and CDIPT 3 0.04 0.85 0.59 71.72
24 INT65676 Binding of CGA and PLOD1 3 0.23 1.68 0.1 71.72
25 INT234800 RAB27A Positive_regulation of INS 1 0.02 1.26 0 70.52
26 INT234793 RAB27A Positive_regulation of Localization of INS 1 0.03 1.26 0 70.52
27 INT295432 FSHR Positive_regulation of PCOS1 1 0.06 1.24 0 65.56
28 INT90593 Binding of Eif3h and Man2a2 1 0.01 0.32 0.38 65.40
29 INT295433 Binding of PLOD1 and SCN5A 1 0.07 0.25 0.16 62.08
30 INT277803 Regulation of GNRH1 Regulation of CGA 1 0.00 0.61 0 62.08
31 INT351001 Binding of Adh7 and Ins1 1 0.00 1.62 0.05 58.68
32 INT241460 Rock1 Positive_regulation of Phosphorylation of MLC1 1 0.38 0.63 0.03 53.84
33 INT6020 Och Regulation of Penk 1 0.00 0.05 0.43 53.12
34 INT44442 GNRH1 Positive_regulation of Localization of PLOD1 3 0.50 0.78 0.86 44.96
35 INT313871 Pde5a Positive_regulation of Pah 1 0.49 0.97 0 43.88
36 INT192914 Binding of ESR1 and GOPC 2 0.02 0.61 0 43.84
37 INT213585 Binding of CFTR and FLNA 1 0.14 0.11 0.03 43.04
38 INT203848 Binding of Pten and Lna1 1 0.06 0.4 0.2 39.28
39 INT342810 Binding of Adarb1 and Gsk3b 1 0.00 0.36 0.3 38.84
40 INT203850 Binding of Tradd and Lna1 1 0.10 0.4 0.2 38.56
41 INT234801 RAB3GAP1 Regulation of RAB3A 1 0.08 1.64 0.15 35.68
42 INT234802 Binding of AQP2 and AVPR2 2 0.15 0.84 0.07 35.52
43 INT234791 Binding of AVP and AVPR2 1 0.14 0.55 0 35.52
44 INT234796 Binding of AQP2 and AVP 1 0.15 1.1 0 35.52
45 INT186248 NR5A1 Positive_regulation of Transcription of STAR 1 0.01 0.21 0 34.64
46 INT330984 Negative_regulation of CYP2D6 Positive_regulation of Localization of CYP1A2 1 0.46 0 0.62 34.08
47 INT213584 Binding of AGTR2 and ACE 1 0.17 0 0 33.04
48 INT256632 Binding of PTCH1 and Jkamp 1 0.00 2.32 0 32.20
49 INT145152 Binding of EGF and EGFR 4 0.15 2.45 0.19 30.72
50 INT200063 Binding of MAGED1 and Ngfr 1 0.44 0.45 0 30.72
51 INT213583 Binding of EGFR and NRG2 1 0.16 0.13 0 30.72
52 INT200055 Binding of Ngfr and Mageh1 1 0.33 0.45 0 30.72
53 INT200065 Binding of MAGED1 and Ntf3 1 0.32 0.23 0 30.16
54 INT200054 Binding of Ntf3 and Mageh1 1 0.24 0.22 0 30.16
55 INT200057 Binding of Ndn and Ngfr 1 0.43 1.96 0 28.88
56 INT199196 Gnat3 Positive_regulation of Aldh2 2 0.26 1.06 0.03 27.72
57 INT29837 Gnrh1 Positive_regulation of LH 6 0.67 0 3.53 25.00
58 INT43688 Gnrh1 Positive_regulation of CGA 1 0.06 0 0 25.00
59 INT318132 Binding of ATRX and HBE1 1 0.00 1.47 0 24.92
60 INT200064 Binding of MAGED1 and Mageh1 1 0.30 0.23 0 24.80
61 INT246478 Binding of SERPINE1 and ANGPTL5 1 0.01 1.32 0.1 23.92
62 INT186239 Binding of ROS1 and Positive_regulation of PDE2A 1 0.00 0 0 21.24
63 INT186241 Gene_expression of ROS1 Positive_regulation of PDE2A 1 0.00 0 0 21.24
64 INT269759 PTH Positive_regulation of DMD 2 0.06 0.37 0.03 19.76
65 INT330986 CYP2C9 Positive_regulation of Gene_expression of CYP3A4 1 0.39 0 0.18 17.36
66 INT330985 CYP2C9 Positive_regulation of Gene_expression of CYP2C19 1 0.34 0 0.18 17.36
67 INT234797 AVP Regulation of GOPC 1 0.01 0.65 0 15.04
68 INT234803 AVP Regulation of AQP2 1 0.11 1.3 0 14.84
69 INT199195 Gnat3 Regulation of Transcription of Hmox1 1 0.24 0.12 0.14 13.48
70 INT200062 Binding of Ngfr and Bbs4 1 0.30 0.3 0 13.12
71 INT200053 Binding of Nuc and Ngfr 1 0.10 0.3 0 13.12
72 INT200061 Binding of Ngfr and Fez1 1 0.31 0.3 0 13.12
73 INT179502 Binding of Cd14 and Tlr4 29 0.39 13.77 5.73 10.52
74 INT273251 Binding of IL6 and IL12A 1 0.00 1.15 0.16 8.88
75 INT199191 Negative_regulation of Sod2 Positive_regulation of Ros1 1 0.08 0 0.19 8.80
76 INT172568 Gene_expression of GNRH1 Regulation of Localization of CGA 1 0.05 0.66 0.08 8.08
77 INT186249 Binding of ROS1 and SCN5A 1 0.09 0.73 0.03 7.56
78 INT189796 Binding of EHHADH and Cd14 1 0.13 0.9 0.14 5.24
79 INT101942 Binding of CD40 and CD40LG 16 0.23 15.24 4.01 5.00
80 INT182635 Binding of CCR5 and CCL5 2 0.09 4.19 3 5.00
81 INT208991 Binding of CALM1 and Ca2 10 0.06 1.34 1.55 5.00
82 INT352269 Binding of Jund and Adora1 1 0.15 1.2 1.25 5.00
83 INT323278 Dhfr Negative_regulation of Negative_regulation of Igkv1-131 1 0.02 0.93 1.02 5.00
84 INT170449 Pax3 Positive_regulation of Spr 1 0.01 0.26 0.99 5.00
85 INT275097 Twist1 Regulation of Ltp 1 0.01 0.37 0.96 5.00
86 INT36683 Gh1 Regulation of Gnrhr 3 0.08 1.25 0.95 5.00
87 INT232426 HRH2 Regulation of Localization of PRL 1 0.15 0.38 0.94 5.00
88 INT199189 Binding of Aldh2 and Ros1 1 0.06 0.3 0.88 5.00
89 INT221257 Pde5a Positive_regulation of PRKG1 3 0.07 0.19 0.86 5.00
90 INT105970 GH1 Regulation of Ghsr 1 0.04 1.16 0.84 5.00
91 INT252455 Binding of Adora2b and SLURP1 1 0.02 0.6 0.81 5.00
92 INT181616 INS Positive_regulation of IRS1 1 0.01 1 0.79 5.00
93 INT181615 SRC Positive_regulation of IRS1 1 0.01 0.98 0.77 5.00
94 INT316544 BCL2L11 Regulation of INS 1 0.00 1.36 0.77 5.00
95 INT257222 Binding of Ltp and Pde5a 2 0.07 0.14 0.75 5.00
96 INT152429 Ghrh Positive_regulation of Localization of Gh 4 0.37 0.56 0.75 5.00
97 INT123229 OXTR Regulation of Localization of PRL 2 0.30 0 0.73 5.00
98 INT261378 Nsdhl Negative_regulation of Gene_expression of Flvcr2 1 0.01 0.34 0.7 5.00
99 INT263236 DAG1 Positive_regulation of Prkcg 2 0.01 0.31 0.7 5.00
100 INT28947 GH1 Positive_regulation of Gene_expression of IGF1 4 0.22 3.78 0.69 5.00
101 INT270762 IL1B Positive_regulation of IL1B Negative_regulation of IKBKB 1 0.02 1.13 0.66 5.00
102 INT270763 IL1B Negative_regulation of IKBKB 1 0.04 1.13 0.66 5.00
103 INT191494 IL6 Positive_regulation of Binding of CRP 1 0.02 1.65 0.65 5.00
104 INT339794 Sstr2 Positive_regulation of Gene_expression of Sstr5 1 0.08 0.25 0.64 5.00
105 INT235082 CA2 Positive_regulation of NOS1 2 0.11 0.62 0.63 5.00
106 INT45780 GNRH1 Positive_regulation of PLOD1 3 0.07 1.02 0.63 5.00
107 INT89902 SST Positive_regulation of Localization of PRL 2 0.40 0 0.61 5.00
108 INT274167 Il13 Regulation of Il5 2 0.09 2.05 0.59 5.00
109 INT275063 CA2 Positive_regulation of Positive_regulation of CAMK4 1 0.01 0 0.59 5.00
110 INT170446 Pax3 Positive_regulation of Gene_expression of Spr 1 0.01 0 0.58 5.00
111 INT261372 Gsk3b Regulation of Gene_expression of Ifi205 1 0.00 0.24 0.58 5.00
112 INT181619 ACE Positive_regulation of KNG1 1 0.33 0.97 0.58 5.00
113 INT156667 Gh Positive_regulation of Gene_expression of Igf1 6 0.28 0.88 0.56 5.00
114 INT209885 TNFSF11 Positive_regulation of TNFRSF11A 3 0.56 3.41 0.55 5.00
115 INT352270 Tnf Positive_regulation of GZMA 1 0.13 2.43 0.55 5.00
116 INT112025 Binding of Hand1 and Il10 2 0.15 0.56 0.55 5.00
117 INT355881 Il17a Regulation of Gene_expression of Hand1 1 0.18 1.51 0.54 5.00
118 INT355878 Il17a Regulation of Eae1 1 0.06 1.52 0.54 5.00
119 INT352268 Tnf Positive_regulation of Arl6ip6 1 0.02 2.42 0.54 5.00
120 INT255463 Binding of Avp and Avpr1a 1 0.06 0.67 0.54 5.00
121 INT316546 Binding of GH1 and SST 2 0.03 0.55 0.54 5.00
122 INT355880 Il17a Regulation of Abi3 1 0.00 1.52 0.54 5.00
123 INT232424 VIP Positive_regulation of Localization of PRL 1 0.36 0 0.53 5.00
124 INT105971 GH1 Regulation of Ghrl 1 0.03 0.75 0.52 5.00
125 INT274170 Il13 Regulation of Il4 3 0.09 2.75 0.51 5.00
126 INT278122 Negative_regulation of P2rx7 Negative_regulation of Binding of P2RX7 1 0.03 0 0.51 5.00
127 INT278105 Negative_regulation of TP63 Negative_regulation of Binding of P2RX7 1 0.00 0 0.51 5.00
128 INT323280 Dhfr Negative_regulation of Igkv1-131 1 0.02 0.47 0.51 5.00
129 INT291556 Binding of ESR1 and Sec22b 2 0.00 0.86 0.5 5.00
130 INT27730 Binding of ALB and Shbg 2 0.01 0.44 0.5 5.00
131 INT252426 Binding of SLURP1 and Negative_regulation of Gene_expression of TNF 1 0.01 1.13 0.49 5.00
132 INT36684 Gh1 Regulation of Prl 2 0.18 1.25 0.48 5.00
133 INT189859 Binding of SLC6A3 and ADHD1 2 0.32 0.68 0.48 5.00
134 INT232427 ABAT Regulation of PRL 1 0.08 0.26 0.45 5.00
135 INT252425 Positive_regulation of AR Positive_regulation of Gene_expression of CXCL10 1 0.00 0.9 0.44 5.00
136 INT258584 ADORA3 Negative_regulation of ADCY1 1 0.02 0 0.44 5.00
137 INT275100 Pde4a Negative_regulation of RTP3 1 0.00 0.51 0.42 5.00
138 INT275087 Pde2a Negative_regulation of stm 1 0.01 0.51 0.42 5.00
139 INT275089 Pde4a Negative_regulation of stm 1 0.02 0.51 0.42 5.00
140 INT275104 Pde2a Negative_regulation of RTP3 1 0.00 0.51 0.42 5.00
141 INT261374 Nsdhl Regulation of Esr2 1 0.05 0.76 0.41 5.00
142 INT261370 Nsdhl Regulation of Esr1 1 0.01 0.75 0.41 5.00
143 INT171990 Binding of DMD and VDR 5 0.05 2.58 0.39 5.00
144 INT191493 Binding of AGTR1 and NLRP3 2 0.03 2.35 0.39 5.00
145 INT275099 Pde9a Negative_regulation of RTP3 1 0.00 0.51 0.39 5.00
146 INT275093 Pde9a Negative_regulation of stm 1 0.00 0.51 0.39 5.00
147 INT232422 VIP Regulation of Gene_expression of PRL 1 0.40 0 0.37 5.00
148 INT232421 Binding of PRL and Positive_regulation of Regulation of ABAT 1 0.09 0 0.37 5.00
149 INT316545 Binding of IGF1 and SST 1 0.06 0.45 0.37 5.00
150 INT78444 Binding of GH1 and IGF1 4 0.16 2.82 0.37 5.00
151 INT275096 Pde9a Regulation of Ltp 1 0.00 0.11 0.35 5.00
152 INT252453 Binding of AR and Adora2b 1 0.05 0 0.35 5.00
153 INT275098 Pde9a Regulation of RTP3 1 0.00 0.11 0.35 5.00
154 INT352547 Binding of CFTR and DMD 1 0.01 1.42 0.35 5.00
155 INT275094 Pde5a Regulation of Ltp 1 0.05 0 0.35 5.00
156 INT232419 ABAT Positive_regulation of Localization of PRL 1 0.09 0 0.33 5.00
157 INT232425 Binding of ABAT and Positive_regulation of PRL 1 0.09 0.15 0.33 5.00
158 INT232420 PRL Positive_regulation of Regulation of ABAT 1 0.09 0 0.33 5.00
159 INT211308 Binding of Cd4 and Cd8a 3 0.19 0.3 0.31 5.00
160 INT199194 Ros1 Negative_regulation of Aldh2 1 0.07 0.27 0.3 5.00
161 INT191499 CMA1 Positive_regulation of NLRP3 1 0.02 0.42 0.3 5.00
162 INT191502 Binding of CMA1 and NLRP3 1 0.01 0.42 0.3 5.00
163 INT341777 SLC6A4 Regulation of EPHB1 1 0.02 0.96 0.3 5.00
164 INT199190 Ros1 Positive_regulation of Aldh2 1 0.08 0.27 0.3 5.00
165 INT247083 Binding of F5 and PLAT 1 0.03 0.88 0.29 5.00
166 INT222301 Binding of ERBB2 and ESR1 5 0.36 5.07 0.29 5.00
167 INT191501 NLRP3 Positive_regulation of ECE1 1 0.01 1.09 0.28 5.00
168 INT191505 NLRP3 Positive_regulation of Protein_catabolism of EDN1 1 0.00 1.1 0.28 5.00
169 INT182499 Binding of AGTR1 and AGTR2 3 0.20 2.79 0.28 5.00
170 INT247081 Binding of F5 and F7 1 0.00 0.87 0.28 5.00
171 INT274172 Negative_regulation of Pde4a Negative_regulation of Positive_regulation of TNF 1 0.02 0.72 0.28 5.00
172 INT191495 NLRP3 Positive_regulation of Protein_catabolism of ECE1 1 0.01 1.09 0.28 5.00
173 INT323152 Binding of DBT and ESR1 2 0.02 1.29 0.27 5.00
174 INT71904 Binding of ESR1 and PGR 6 0.34 3.79 0.27 5.00
175 INT191503 CD40LG Regulation of Gene_expression of F3 1 0.01 0.99 0.27 5.00
176 INT191497 Binding of REN and NLRP3 1 0.02 0.55 0.27 5.00
177 INT191504 CPN2 Positive_regulation of NLRP3 1 0.00 0.37 0.27 5.00
178 INT257577 CALCA Positive_regulation of DMD 1 0.01 0.57 0.26 5.00
179 INT272997 Binding of CYP3A4 and IL33 1 0.03 0 0.25 5.00
180 INT272998 IL33 Negative_regulation of CYP2D6 1 0.04 0 0.25 5.00
181 INT105966 GH1 Regulation of GHS 1 0.03 0.37 0.25 5.00
182 INT261375 Binding of Nsdhl and Pparg 1 0.05 1.03 0.25 5.00
183 INT191498 Binding of CTSG and NLRP3 1 0.07 0.37 0.25 5.00
184 INT264569 Binding of STS and ATF7IP 1 0.03 0.15 0.25 5.00
185 INT275092 Twist1 Regulation of stm 1 0.00 0 0.25 5.00
186 INT191496 CTSG Positive_regulation of NLRP3 1 0.09 0.37 0.25 5.00
187 INT191500 ACE Positive_regulation of Localization of KNG1 1 0.10 0.17 0.24 5.00
188 INT239087 Binding of SST and Negative_regulation of Localization of GH1 1 0.19 0.36 0.24 5.00
189 INT252427 IGKV2D-29 Regulation of Gene_expression of AR 1 0.02 0 0.24 5.00
190 INT252456 IGKV2D-29 Regulation of Gene_expression of Adora2b 1 0.07 0 0.24 5.00
191 INT191536 Klk1c2 Positive_regulation of NLRP3 1 0.02 0.36 0.24 5.00
192 INT261394 Nsdhl Negative_regulation of nt 1 0.01 1.69 0.24 5.00
193 INT191537 Binding of Klk1c2 and NLRP3 1 0.02 0.36 0.24 5.00
194 INT191492 Binding of AGT and NLRP3 1 0.01 0.35 0.23 5.00
195 INT234755 IL10 Positive_regulation of IFN1@ 1 0.08 0.68 0.23 5.00
196 INT261389 Nsdhl Positive_regulation of Esr2 1 0.06 1.04 0.23 5.00
197 INT234831 Binding of SPTLC1 and Abo 1 0.00 1.61 0.23 5.00
198 INT279503 Binding of C1s and C1ra 1 0.03 0.58 0.22 5.00
199 INT341779 DBT Positive_regulation of PRKCA 1 0.02 0 0.22 5.00
200 INT351318 Binding of CYP2C19 and Cyp1a2 1 0.01 0.28 0.22 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Reprotox - General 2. They are ordered first by their pain relevance and then by number of times they were reported in Reprotox - General 2. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT5460 Positive_regulation of EDAR 10 0.23 8.18 2.71 100.00
2 INT17275 Gene_expression of HIVEP1 267 0.75 232.07 24.06 100.00
3 INT528 Gene_expression of Prl 693 0.78 217.18 192.2 100.00
4 INT56118 Gene_expression of EDAR 27 0.35 6.33 0.82 100.00
5 INT79598 Regulation of PDE5A 16 0.60 8.68 1.17 100.00
6 INT28733 Regulation of EDAR 4 0.12 2.11 0.89 100.00
7 INT233322 Negative_regulation of Localization of HIVEP1 4 0.10 6.1 0.57 100.00
8 INT270356 Positive_regulation of Positive_regulation of EDAR 1 0.01 1.56 0 100.00
9 INT2296 Positive_regulation of Gene_expression of Prl 137 0.70 36.96 35.39 100.00
10 INT160568 Positive_regulation of PADI4 7 0.45 10.5 0.41 100.00
11 INT227944 Binding of EDAR 5 0.25 2.88 0.07 100.00
12 INT51411 Negative_regulation of EDAR 8 0.41 1.05 5.49 100.00
13 INT229632 Binding of PADI4 21 0.48 37.45 0.34 100.00
14 INT82051 Negative_regulation of RNASE3 8 0.32 6.81 0.53 100.00
15 INT5061 Negative_regulation of Mme 306 0.59 51.97 136.9 100.00
16 INT9832 Gene_expression of Shbg 96 0.75 56.71 12.19 100.00
17 INT238096 Positive_regulation of ELL 4 0.09 2.68 0.16 100.00
18 INT50387 Negative_regulation of AR 67 0.45 26.31 6.61 100.00
19 INT71946 Negative_regulation of Ass1 7 0.41 1.9 2.68 100.00
20 INT45675 Regulation of Gene_expression of Shbg 6 0.15 4.65 1.03 100.00
21 INT25022 Binding of PAEP 66 0.42 22.83 6.59 100.00
22 INT22798 Regulation of Shbg 64 0.60 26.71 8.76 100.00
23 INT30443 Positive_regulation of AIS 30 0.54 22.59 7.2 100.00
24 INT61874 Negative_regulation of Positive_regulation of Arc 2 0.27 1.16 0.79 100.00
25 INT197024 Binding of STIP1 11 0.35 10.84 0.52 100.00
26 INT198393 Transcription of pid 2 0.51 2.01 0.2 100.00
27 INT313870 Negative_regulation of Pah 1 0.48 2.33 0 100.00
28 INT36133 Binding of pid 22 0.42 31.34 4.1 99.98
29 INT156671 Gene_expression of Vcsa1 22 0.75 23.32 1.69 99.96
30 INT2614 Gene_expression of CGA 187 0.78 105.89 24.77 99.96
31 INT270346 Regulation of Gene_expression of Vcsa1 9 0.59 8.88 0.17 99.96
32 INT127372 Gene_expression of Ager 9 0.57 14.44 0.98 99.96
33 INT3559 Negative_regulation of Localization of Gnrhr 73 0.58 18.89 26.41 99.96
34 INT76336 Negative_regulation of PDE5A 192 0.59 112.02 20.09 99.92
35 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 99.90
36 INT306167 Regulation of Etfdh 1 0.05 4.1 0.26 99.90
37 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 99.90
38 INT155 Positive_regulation of Prl 1233 0.70 317.93 457.82 99.84
39 INT6726 Positive_regulation of Edn1 118 0.70 65.96 24.07 99.84
40 INT5806 Regulation of Edn1 63 0.62 23.46 13.88 99.84
41 INT55853 Positive_regulation of Positive_regulation of Edn1 11 0.61 6.5 2.21 99.84
42 INT1512 Binding of Prl 73 0.48 26.22 20.63 99.80
43 INT151904 Binding of Ager 4 0.18 8.07 0.6 99.80
44 INT7834 Gene_expression of Pde2a 5 0.51 1.9 1.01 99.80
45 INT323262 Negative_regulation of Negative_regulation of Pde5a 1 0.03 1.32 0.04 99.80
46 INT60252 Binding of HIVEP1 59 0.32 65.12 5.06 99.78
47 INT257299 Binding of Pde5a 14 0.27 4.31 2.45 99.78
48 INT7970 Gene_expression of PLOD1 120 0.71 44.42 15.54 99.76
49 INT152223 Binding of BEST1 10 0.29 6.67 1.46 99.76
50 INT44544 Gene_expression of ENOPH1 18 0.76 10.28 2.35 99.76
51 INT767 Localization of Gnrhr 565 0.80 106.68 214.57 99.74
52 INT92877 Gene_expression of PDE5A 35 0.76 17.1 2.7 99.72
53 INT62487 Localization of HIVEP1 35 0.73 36.24 2.72 99.72
54 INT79599 Protein_catabolism of PDE5A 7 1.00 3.16 0.39 99.72
55 INT695 Binding of POMC 304 0.48 56.66 126.85 99.72
56 INT24820 Positive_regulation of Binding of POMC 9 0.67 2.98 4.6 99.72
57 INT8662 Positive_regulation of EDN1 144 0.70 125.34 19.59 99.68
58 INT175298 Gene_expression of Meta 7 0.75 2.37 1.85 99.60
59 INT162 Regulation of Prl 794 0.62 165.01 322.24 99.56
60 INT3375 Gene_expression of IGHE 535 0.77 387.47 65.46 99.54
61 INT3988 Positive_regulation of Gene_expression of IGHE 98 0.68 91.46 9.61 99.54
62 INT94859 Negative_regulation of Pde5a 67 0.43 33.66 10.28 99.50
63 INT18660 Binding of Gnrhr 45 0.41 10.6 16.85 99.48
64 INT6441 Positive_regulation of CRH 98 0.69 57.22 24.12 99.48
65 INT17276 Negative_regulation of Gene_expression of HIVEP1 27 0.42 26.85 2.61 99.44
66 INT34720 Positive_regulation of SHBG 58 0.69 32.4 3.83 99.42
67 INT31964 Localization of Trpc6 4 0.65 0.63 0.3 99.42
68 INT35600 Positive_regulation of Plk1s1 7 0.40 0.6 4.26 99.42
69 INT6260 Negative_regulation of St8sia2 6 0.42 0.1 3.09 99.42
70 INT7395 Localization of GNRH1 399 0.81 62.88 117.68 99.40
71 INT2261 Gene_expression of Lhb 121 0.77 42.78 26.04 99.40
72 INT7397 Negative_regulation of Localization of GNRH1 86 0.59 15.45 29.78 99.40
73 INT10104 Negative_regulation of Edn1 43 0.59 15.63 7.2 99.38
74 INT156 Negative_regulation of Prl 542 0.59 131.97 192.24 99.38
75 INT148107 Binding of CDIPT 8 0.17 4.56 0.53 99.38
76 INT1793 Localization of CGA 379 0.81 67.38 114.69 99.36
77 INT7113 Negative_regulation of Localization of CGA 71 0.51 17.7 23.42 99.36
78 INT6584 Negative_regulation of Pax3 31 0.39 14.64 27.97 99.36
79 INT5095 Localization of Ghrh 185 0.81 28.09 62.08 99.36
80 INT334924 Binding of MEHMO 1 0.01 9.69 0.26 99.32
81 INT174590 Regulation of GLG1 5 0.27 5.54 0.72 99.24
82 INT7035 Regulation of CGA 87 0.45 29.04 28.45 99.20
83 INT107593 Regulation of Ecd 2 0.21 1.16 0.23 99.20
84 INT3933 Positive_regulation of PLOD1 128 0.70 30.76 42.03 99.18
85 INT270347 Gene_expression of Smr3a 1 0.01 2.51 0 99.16
86 INT5130 Regulation of GNRH1 139 0.62 31.95 42.08 99.16
87 INT270338 Negative_regulation of Gene_expression of Smr3a 1 0.01 1.49 0 99.16
88 INT719 Negative_regulation of SGCG 96 0.57 47.91 30.22 99.12
89 INT4145 Gene_expression of FSHR 124 0.77 44.98 13.04 99.12
90 INT956 Negative_regulation of PRL 94 0.59 42.72 23.01 99.12
91 INT8786 Negative_regulation of ALDH7A1 27 0.52 12.81 4.76 99.12
92 INT1497 Negative_regulation of Gh 415 0.59 192.95 74.71 99.12
93 INT55733 Negative_regulation of VTN 47 0.58 47.22 5.68 99.12
94 INT95207 Negative_regulation of Pde5a 46 0.58 32.01 10.14 99.08
95 INT270337 Negative_regulation of Vcsa1 1 0.31 1.24 0 99.08
96 INT4771 Gene_expression of CGB 23 0.67 14.22 3.42 99.08
97 INT22128 Positive_regulation of HIVEP1 61 0.43 70.52 6.07 99.06
98 INT270335 Negative_regulation of Negative_regulation of Smr3a 1 0.01 4.1 0 99.04
99 INT270339 Negative_regulation of Smr3a 1 0.01 4.09 0 99.04
100 INT5363 Negative_regulation of PEPD 11 0.56 6.49 3.11 99.04
101 INT355123 Regulation of Negative_regulation of PEPD 1 0.27 0.28 0 99.04
102 INT720 Positive_regulation of POMC 807 0.70 237.37 353.83 99.04
103 INT82078 Negative_regulation of Lep 54 0.59 20.47 9.38 99.04
104 INT64969 Transcription of HTC2 2 0.35 1.1 0.64 99.02
105 INT50579 Binding of CYP3A4 84 0.48 17.52 17.45 98.96
106 INT53929 Positive_regulation of GNPTAB 12 0.32 6.66 1.4 98.96
107 INT346081 Gene_expression of Adhfe1 1 0.10 22.15 6.58 98.96
108 INT95585 Negative_regulation of Pde12 18 0.43 8.32 11.23 98.96
109 INT16167 Negative_regulation of DMD 186 0.57 108.71 15.25 98.94
110 INT1221 Regulation of SGCG 65 0.60 24.21 22.94 98.92
111 INT114862 Gene_expression of BEST1 16 0.65 12.14 1.53 98.88
112 INT5455 Negative_regulation of Localization of CRH 16 0.49 7.31 6.41 98.88
113 INT56375 Positive_regulation of AMBP 25 0.60 21.24 2.22 98.88
114 INT103043 Binding of PDE5A 16 0.37 7.79 1.12 98.86
115 INT4941 Positive_regulation of Oprd1 345 0.70 74.26 304.41 98.82
116 INT14510 Gene_expression of SOD1 208 0.76 88.56 12.4 98.80
117 INT350999 Gene_expression of Adh7 1 0.02 1.64 0.05 98.80
118 INT36132 Negative_regulation of pid 12 0.43 15.15 1.73 98.76
119 INT117995 Regulation of Negative_regulation of PDE5A 3 0.44 2.4 0.29 98.76
120 INT7975 Regulation of PLOD1 97 0.62 20.9 30.51 98.76
121 INT15837 Binding of CGA 31 0.41 12.06 3.17 98.74
122 INT147582 Negative_regulation of AIS 13 0.37 13.26 2.46 98.72
123 INT238653 Regulation of MTX1 2 0.30 1.71 1.42 98.66
124 INT1579 Gene_expression of PRL 279 0.78 119.2 55.41 98.64
125 INT200443 Positive_regulation of AES 27 0.60 22.46 3.22 98.64
126 INT38625 Gene_expression of ELL 8 0.58 12.53 1 98.64
127 INT299966 Negative_regulation of EPC1 10 0.22 8.66 1.07 98.62
128 INT91817 Positive_regulation of RETNLB 22 0.34 21.4 13.12 98.56
129 INT36237 Gene_expression of Ass1 11 0.24 2.31 4.38 98.54
130 INT2982 Positive_regulation of Gene_expression of CGA 17 0.59 9.08 1.99 98.48
131 INT27627 Binding of Rac1 41 0.41 22.88 13.68 98.48
132 INT5864 Localization of IL36RN 19 0.44 14.5 6.87 98.48
133 INT104446 Binding of Atp7b 2 0.09 0.77 0.53 98.48
134 INT130372 Transcription of PDE5A 7 0.72 1.93 0.4 98.40
135 INT619 Positive_regulation of Positive_regulation of Prl 116 0.70 22.69 45.06 98.36
136 INT2197 Gene_expression of Gnrh1 184 0.78 40.04 50.57 98.36
137 INT36449 Negative_regulation of G6PD 74 0.59 54.15 8.85 98.32
138 INT51803 Negative_regulation of Pde7a 14 0.59 14.98 4.85 98.32
139 INT229212 Positive_regulation of MAEA 3 0.43 3.06 0.06 98.32
140 INT1893 Localization of Gh 1041 0.79 340.23 256.58 98.32
141 INT5865 Positive_regulation of Localization of Gh 282 0.69 84.86 93.5 98.32
142 INT15918 Gene_expression of Serpine1 60 0.62 41.73 7.72 98.28
143 INT3466 Gene_expression of Ptger1 39 0.75 18.34 15.75 98.28
144 INT467 Gene_expression of POMC 1048 0.78 332.8 394.16 98.26
145 INT153606 Localization of Pde4a 2 0.69 1.23 1.79 98.26
146 INT8340 Negative_regulation of SHBG 49 0.57 35.96 4.73 98.24
147 INT80630 Protein_catabolism of PDE2A 2 0.19 0.91 0.08 98.24
148 INT80629 Negative_regulation of Protein_catabolism of PDE2A 1 0.12 0.18 0 98.24
149 INT5781 Gene_expression of Edn1 190 0.78 99.1 46 98.20
150 INT198101 Negative_regulation of AVSD1 2 0.19 0.89 0.08 98.20
151 INT4144 Gene_expression of SHBG 64 0.68 39.94 6.08 98.16
152 INT915 Positive_regulation of PRL 342 0.70 141.96 104.31 98.12
153 INT1894 Negative_regulation of Localization of Gh 168 0.58 64.12 43.56 98.08
154 INT21650 Regulation of OXTR 29 0.61 5.99 4.91 98.08
155 INT39518 Negative_regulation of HBN1 66 0.09 37.54 2.58 98.06
156 INT10824 Negative_regulation of Cyp19a1 38 0.57 25.18 3.56 98.04
157 INT1794 Regulation of Localization of CGA 136 0.57 13.39 59.07 98.00
158 INT72060 Positive_regulation of Gene_expression of Ros1 127 0.41 76.76 20.91 97.98
159 INT270345 Negative_regulation of Gene_expression of Vcsa1 1 0.48 3.38 0 97.80
160 INT17620 Positive_regulation of Gnrh1 23 0.70 9.77 3.79 97.80
161 INT74688 Regulation of Nos1 55 0.62 22.16 25.3 97.80
162 INT425 Localization of PRL 455 0.81 189.64 144.8 97.76
163 INT2122 Negative_regulation of Localization of Gnrh1 226 0.59 26.92 92.04 97.76
164 INT30610 Localization of PCa 35 0.65 13.91 4.25 97.72
165 INT9243 Gene_expression of FOXG1 14 0.53 7.52 1.02 97.64
166 INT49468 Negative_regulation of Pah 28 0.55 24.95 6.29 97.60
167 INT9900 Positive_regulation of Vwf 80 0.69 51.85 18.13 97.56
168 INT28692 Positive_regulation of CIC 3 0.49 2.92 0.43 97.56
169 INT55344 Gene_expression of Ros1 396 0.54 217.64 59.98 97.54
170 INT5128 Positive_regulation of Lhb 232 0.69 44.23 71.26 97.52
171 INT7224 Positive_regulation of Gene_expression of Lhb 18 0.45 10.22 3.4 97.52
172 INT8332 Positive_regulation of OPRD1 30 0.61 3.88 17.65 97.52
173 INT53536 Gene_expression of Bw86 8 0.30 0.89 5.21 97.52
174 INT43586 Positive_regulation of Cyth3 1 0.01 0.1 0.44 97.52
175 INT11831 Positive_regulation of pid 13 0.40 23.37 1.54 97.44
176 INT1603 Negative_regulation of Rtcd1 131 0.51 29.99 66.66 97.44
177 INT2159 Regulation of Localization of Gnrh1 200 0.62 13.28 99.07 97.44
178 INT770 Regulation of Localization of Gnrhr 127 0.61 17.91 58.23 97.44
179 INT46687 Negative_regulation of Snd1 7 0.38 2.47 2.59 97.44
180 INT187005 Positive_regulation of Gene_expression of Ghrh 9 0.48 8.02 0.29 97.32
181 INT17621 Positive_regulation of Gene_expression of Gnrh1 5 0.70 2.59 0.24 97.32
182 INT5135 Negative_regulation of GNRH1 106 0.58 36.63 27.71 97.24
183 INT5127 Localization of Lhb 488 0.80 50.48 162.66 97.12
184 INT71047 Gene_expression of CYP19A1 122 0.78 68.78 22.21 97.12
185 INT71995 Binding of Crygs 54 0.11 10.03 39.31 97.08
186 INT20966 Positive_regulation of Arc 30 0.70 24.38 15.62 97.08
187 INT439 Localization of Gnrh1 976 0.81 100.96 363.25 97.04
188 INT155609 Phosphorylation of pid 2 0.54 3.15 1.62 97.04
189 INT7396 Regulation of Localization of GNRH1 81 0.62 6.57 31.31 97.02
190 INT2415 Binding of MAOA 26 0.47 13.26 11.86 96.96
191 INT170770 Positive_regulation of UGCG 4 0.24 1.34 0.03 96.96
192 INT16166 Positive_regulation of DMD 348 0.67 133.22 15.06 96.92
193 INT351000 Binding of Adh7 1 0.01 3.4 0.03 96.92
194 INT211968 Localization of Best1 11 0.40 9.33 0.38 96.92
195 INT5454 Localization of CRH 124 0.79 79.18 41.53 96.88
196 INT82347 Regulation of PLXNA3 5 0.60 4.59 2.45 96.88
197 INT270343 Negative_regulation of Regulation of Vcsa1 1 0.35 1.39 0 96.80
198 INT56374 Gene_expression of AMBP 34 0.54 35.85 6.25 96.72
199 INT225056 Positive_regulation of Gene_expression of AMBP 4 0.37 5.45 0.75 96.72
200 INT313933 Transcription of Vms1 1 0.22 0.83 0.09 96.64
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