D:Reprotox - General 3

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Disease Term
Synonyms Gray Syndrome, HAEMORRHAGIC ERUPTION, Hematospermia, IMPAIRED FERTILITY, Impairment Of Fertility, Increase In Sizes Of Uterine Fibromyomata, Increased Frequency Of Erections, Increased Incidence Of Forceps Delivery, INCREASED MENSTRUATION, Infertility, Inflammation Of Fallopian Tube
Documents 6338
Hot Single Events 200
Hot Interactions 42

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Reprotox - General 3. They are ordered first by their relevance to Reprotox - General 3 and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT186240 Binding of AGRP and SCN5A 2 0.13 1.19 0.1 100.00
2 INT186245 Binding of AGRP and CAT 1 0.02 0.53 0.1 100.00
3 INT186244 Binding of AGRP and ALB 1 0.03 0.53 0.1 100.00
4 INT346305 Binding of ELANE and Col2a1 1 0.00 0.98 0.17 99.52
5 INT192956 Binding of CD2 and KIT 1 0.03 0.62 0 98.12
6 INT192955 Binding of KIT and VCAM1 1 0.05 0.63 0 98.12
7 INT230594 Binding of Hrh1 and Hrh2 1 0.24 0.99 1.02 97.84
8 INT164227 Binding of PAEP and Tnfrsf11b 1 0.00 1.18 0.77 97.66
9 INT237928 BCL2 Positive_regulation of FAS 1 0.02 1.41 0.26 97.60
10 INT237925 BCL2 Positive_regulation of Protein_catabolism of PARP1 1 0.02 1.42 0.26 97.60
11 INT237927 BCL2 Positive_regulation of BAX 2 0.24 2.22 0.26 97.60
12 INT313384 Binding of PDLIM5 and ZMYND10 1 0.04 0.82 0 96.76
13 INT237919 BAX Positive_regulation of Protein_catabolism of PARP1 1 0.03 1.41 0.26 96.72
14 INT295431 FSHR Positive_regulation of CGA 1 0.29 0.27 0 95.72
15 INT147936 CGA Regulation of Gene_expression of FSHR 1 0.31 0.71 0.1 95.36
16 INT186246 Binding of CAT and SCN5A 1 0.03 0.47 0.1 94.32
17 INT268652 Binding of CLDN4 and LIF 1 0.35 0.44 0.04 93.76
18 INT188290 Ghrl Regulation of Gene_expression of Kitlg 1 0.02 0.15 0 93.36
19 INT267778 Binding of Mvp and Gopc 1 0.12 0.83 0 93.28
20 INT198382 Binding of AR and SRD5A1 2 0.06 0.84 0.17 92.84
21 INT246413 TLR4 Regulation of TLR3 1 0.28 0.81 0.05 92.68
22 INT333274 Binding of Tlr4 and Tlr4 Positive_regulation of Localization of Il6 1 0.21 0.59 0.23 92.56
23 INT332741 BPIFA1 Negative_regulation of ENO1 1 0.32 0.99 0.17 90.88
24 INT294309 PROK1 Regulation of Gene_expression of IL11 1 0.53 0.25 0.15 89.84
25 INT186242 Binding of ALB and SCN5A 1 0.04 0.36 0.1 87.72
26 INT176564 Binding of Cyp17a1 and Cyp19a1 1 0.03 0.33 0 85.92
27 INT260131 CGA Negative_regulation of OFC1 1 0.01 0.17 0 85.76
28 INT159794 Tnf Positive_regulation of Mapk9 1 0.01 0.42 0.19 85.56
29 INT159795 Tnf Positive_regulation of TLR4 1 0.01 0.42 0.19 85.56
30 INT159796 Tnf Positive_regulation of Gene_expression of TLR4 1 0.02 0.42 0.19 85.56
31 INT159793 Tnf Positive_regulation of Gene_expression of Mapk9 1 0.01 0.42 0.19 85.56
32 INT188295 Binding of KITLG and Ghrl 1 0.02 0.09 0 85.52
33 INT243370 Des Positive_regulation of Ppara 1 0.15 0.36 0 85.04
34 INT294292 PROK1 Regulation of IL11 1 0.53 0.42 0.17 84.08
35 INT294303 PTGER2 Positive_regulation of Localization of IL11 1 0.04 0.08 0.03 83.84
36 INT330486 MSR1 Negative_regulation of TAC1 1 0.01 0.23 0.13 83.60
37 INT330485 MSR1 Negative_regulation of TACR1 1 0.01 0.23 0.13 83.60
38 INT241500 Binding of Kit and Kitl 1 0.08 0.92 0 83.00
39 INT182496 AGT Positive_regulation of Phosphorylation of STAT3 1 0.03 0.79 0.12 82.28
40 INT294301 PTGER2 Positive_regulation of IL11 1 0.04 0.08 0.03 81.68
41 INT246437 Ccl5 Positive_regulation of Regulation of Hand1 1 0.19 0.76 0.17 80.40
42 INT214691 Binding of CGA and CGB 1 0.01 0.7 0.17 80.24
43 INT181455 Binding of Ccr5 and Ccl5 11 0.39 12.13 3.66 79.84
44 INT159788 Tnf Positive_regulation of Phosphorylation of Nfkbia 1 0.01 0.39 0.19 79.16
45 INT2161 Gnrh1 Positive_regulation of Localization of LH 33 0.73 0.87 14.34 78.72
46 INT199970 CYP19A1 Positive_regulation of Gene_expression of ESR1 1 0.06 0.72 0.25 77.48
47 INT266771 Binding of NGF and GOPC 1 0.05 3.23 1.43 76.88
48 INT267777 Positive_regulation of Binding of Mvp and IgG 1 0.12 0.89 0 76.72
49 INT267783 Binding of Mvp and IgG 1 0.09 0.89 0 76.72
50 INT103279 PGR Negative_regulation of Gene_expression of CCL5 1 0.32 0.31 0.27 76.64
51 INT103280 PGR Negative_regulation of Positive_regulation of ATF4 1 0.02 0.31 0.26 76.64
52 INT199973 ESR1 Negative_regulation of EEF1B2P2 1 0.01 0.46 0.08 76.00
53 INT199976 EGF Regulation of ITGB3BP 1 0.02 0.77 0.57 74.04
54 INT199978 ESR1 Regulation of ITGB3BP 1 0.03 0.39 0.28 74.04
55 INT273251 Binding of IL6 and IL12A 1 0.00 1.15 0.16 73.12
56 INT109091 Tnf Positive_regulation of Localization of Il1b 1 0.56 1.08 0.36 72.52
57 INT234755 IL10 Positive_regulation of IFN1@ 1 0.08 0.68 0.23 72.12
58 INT266806 Hand2 Regulation of Gene_expression of IL10 1 0.00 1.23 0.32 70.48
59 INT266804 Hand2 Regulation of Gene_expression of IL13 1 0.00 1.23 0.32 70.48
60 INT266805 Hand2 Regulation of Gene_expression of IL4 1 0.00 1.23 0.32 70.48
61 INT230595 Binding of TNF and Tecr 1 0.03 1 0.62 70.36
62 INT95103 TGFBR2 Positive_regulation of CD34 1 0.11 0.61 0.14 68.36
63 INT95104 TGFBR2 Positive_regulation of BCL2 1 0.08 0.61 0.14 68.36
64 INT268651 NUPL2 Positive_regulation of Gene_expression of LIF 1 0.66 0.07 0 68.20
65 INT327198 DBT Positive_regulation of Gene_expression of ESRRA 1 0.00 0.42 0 67.88
66 INT35373 Negative_regulation of Dlst Positive_regulation of Tk1 1 0.02 0.27 0.11 67.48
67 INT35374 Dlst Positive_regulation of Tk1 1 0.02 0.26 0.11 67.16
68 INT199971 IL6 Positive_regulation of ESR1 1 0.08 0.84 0.24 64.88
69 INT294313 Gene_expression of CABIN1 Positive_regulation of IL11 1 0.03 0.06 0 64.60
70 INT199974 ESR1 Negative_regulation of Gene_expression of ITGB3BP 1 0.05 0.47 0.38 63.76
71 INT350121 INS Negative_regulation of Positive_regulation of SHBG 1 0.09 1.48 0.04 59.12
72 INT251469 INS Negative_regulation of Gene_expression of SHBG 2 0.11 4.11 0.08 59.12
73 INT350118 INS Negative_regulation of SHBG 1 0.09 1.42 0.04 59.12
74 INT355882 TNF Positive_regulation of Gene_expression of Il12b 1 0.03 0.21 0.18 56.56
75 INT168295 PROC Regulation of Gene_expression of VEGFA 2 0.00 1.6 0.67 54.24
76 INT266082 PROC Regulation of Localization of VEGFA 1 0.00 0.84 0.05 54.24
77 INT290565 Binding of Rare1 and Rorb 1 0.00 0.32 0.12 52.48
78 INT186249 Binding of ROS1 and SCN5A 1 0.09 0.73 0.03 52.24
79 INT25036 TRH Regulation of Prl 4 0.27 1.75 1.09 50.00
80 INT17414 TRH Positive_regulation of Prl 4 0.47 0 1.07 50.00
81 INT45780 GNRH1 Positive_regulation of PLOD1 3 0.07 1.02 0.63 50.00
82 INT45738 TRH Positive_regulation of TRH Regulation of Prl 2 0.51 0.61 0.17 50.00
83 INT65676 Binding of CGA and PLOD1 3 0.23 1.68 0.1 50.00
84 INT187671 CGA Negative_regulation of Gene_expression of GNRH1 1 0.01 0 0.06 50.00
85 INT187732 Binding of CYP19A1 and Cyp11a1 1 0.01 0.68 0.04 50.00
86 INT187676 Binding of CYP19A1 and SHBG 1 0.01 0.63 0.03 50.00
87 INT187672 Binding of DBT and SCN5A 1 0.00 0.2 0 50.00
88 INT187677 Negative_regulation of FSHR Positive_regulation of DBT 1 0.03 0 0 50.00
89 INT187675 DBT Positive_regulation of Gene_expression of LEP 1 0.04 0.27 0 50.00
90 INT187674 FSHR Positive_regulation of Gene_expression of CYP19A1 1 0.24 0 0 50.00
91 INT187667 DBT Positive_regulation of Localization of LEP 1 0.05 0.55 0 50.00
92 INT187669 FSHR Positive_regulation of DBT 1 0.03 0 0 50.00
93 INT187673 GNRH1 Regulation of Localization of PLOD1 1 0.06 0.09 0 50.00
94 INT187670 Gene_expression of FSHR Positive_regulation of Gene_expression of CYP19A1 1 0.16 0 0 50.00
95 INT187668 Negative_regulation of GNRH1 Positive_regulation of PLOD1 1 0.06 0.07 0 50.00
96 INT131249 Binding of Bdnf and Ntrk2 11 0.41 4 6.25 49.60
97 INT252605 Ppig Positive_regulation of Gene_expression of Cx3cr1 1 0.09 1.81 0.69 48.80
98 INT294291 PROK1 Regulation of Localization of IL11 1 0.53 0 0.05 48.56
99 INT252603 Ppig Positive_regulation of Gene_expression of Cx3cl1 1 0.10 1.8 0.69 48.36
100 INT290563 Binding of Rxrg and Rorb 1 0.00 0.2 0.12 47.44
101 INT192914 Binding of ESR1 and GOPC 2 0.02 0.61 0 47.36
102 INT291556 Binding of ESR1 and Sec22b 2 0.00 0.86 0.5 47.00
103 INT134927 CYP19A1 Positive_regulation of Gene_expression of MME 1 0.30 1.04 0.28 46.92
104 INT134930 MME Positive_regulation of Gene_expression of CYP19A1 1 0.30 1.04 0.28 46.92
105 INT222335 Binding of Bdnf and Ngfr 3 0.05 2.66 1.48 43.44
106 INT291554 Binding of ESR1 and St8sia2 1 0.01 0.49 0.33 43.16
107 INT332740 Binding of ENO1 and BPIFA1 1 0.31 0.71 0.09 43.04
108 INT176569 Binding of FSHR and Cyp19a1 1 0.04 0.06 0 42.96
109 INT179846 Il11 Regulation of Positive_regulation of Rps6 1 0.04 0.07 0.17 41.92
110 INT266803 Dlst Positive_regulation of VEGFA 1 0.01 0.96 0.25 41.36
111 INT250538 Igf1 Positive_regulation of Gh 1 0.24 0.05 0.06 40.96
112 INT266801 Dlst Positive_regulation of IL8 1 0.00 0.95 0.25 40.56
113 INT238009 Binding of Cxcr3 and Cxcl9 3 0.40 4.01 1.37 40.40
114 INT237083 Binding of Cxcl10 and Cxcl9 2 0.39 3.19 0.87 40.40
115 INT237084 Binding of Cxcl9 and Cxcl11 2 0.34 3.19 0.87 40.40
116 INT252601 Binding of Cxcl10 and Cxcl11 1 0.34 1.68 0.6 40.12
117 INT266802 Dlst Positive_regulation of CCL5 1 0.00 0.95 0.25 40.08
118 INT179837 Il11 Regulation of Positive_regulation of Rps6kb2 1 0.06 0.07 0.17 39.92
119 INT47482 PRL Regulation of Gene_expression of LGALS1 1 0.19 0 0 39.68
120 INT237999 Binding of Cxcr3 and Cxcl11 2 0.45 3.49 1.11 39.64
121 INT317584 Binding of Lbp and Pgp 1 0.24 1.08 0.99 39.04
122 INT179841 Il11 Regulation of Positive_regulation of Akt1 1 0.08 0.07 0.17 38.72
123 INT179849 Il11 Regulation of Positive_regulation of Pdpk1 1 0.05 0.07 0.17 38.40
124 INT204995 Ppp1r15b Regulation of Gene_expression of Pink1 1 0.01 0.97 0 38.20
125 INT318303 Negative_regulation of Myoz1 Negative_regulation of Transcription of IL2 1 0.00 0.75 0.21 37.20
126 INT204994 Positive_regulation of Hras1 Positive_regulation of Gene_expression of Pink1 1 0.05 0.97 0 35.04
127 INT265346 Binding of Ocln and Tjp1 7 0.05 1.11 0.09 33.12
128 INT352525 SLC25A16 Negative_regulation of SMO 1 0.00 1.1 0 32.96
129 INT182194 Binding of IL8 and CXCR2 10 0.56 7.14 4.16 31.12
130 INT208572 Binding of IL8 and CXCR1 6 0.33 5.2 3.08 31.12
131 INT302493 Binding of AGRP and IMPACT 1 0.25 0.53 0 30.52
132 INT355877 Binding of Hand1 and Il4 1 0.14 0.25 0.22 29.96
133 INT112025 Binding of Hand1 and Il10 2 0.15 0.56 0.55 29.64
134 INT246414 TLR4 Regulation of Gene_expression of TLR3 1 0.35 1.16 0.17 28.88
135 INT173058 INCENP Positive_regulation of Gene_expression of VEGFA 1 0.03 1.48 0.08 27.52
136 INT291543 Binding of Dlat and Gper 1 0.15 0.37 0.33 27.16
137 INT173057 Positive_regulation of HIF1A Positive_regulation of Gene_expression of VEGFA 1 0.24 1.49 0.08 25.84
138 INT151902 PLG Positive_regulation of Protein_catabolism of F13A1 1 0.00 0.16 0 25.00
139 INT199975 ESR1 Positive_regulation of PGR 1 0.05 0.11 0 21.60
140 INT233278 Binding of LBX1 and Tgif1 1 0.00 0.25 0.06 21.36
141 INT205000 Binding of Xpo5 and Pol 1 0.01 0.27 0 20.72
142 INT257397 Binding of FGD1 and INS 1 0.07 0.27 0.21 20.52
143 INT257398 Binding of FGD1 and GHRH 1 0.03 0.27 0.2 20.52
144 INT234439 Binding of NR1H4 and HCC 1 0.06 0.82 0 20.48
145 INT181311 Binding of DMD and KRT20 1 0.01 0.07 0 20.04
146 INT292814 Binding of VEGFA and Kdr 8 0.18 3.63 0.48 18.76
147 INT229394 TPSD1 Positive_regulation of F2RL1 2 0.00 3.11 2.14 14.88
148 INT260944 Mapk14 Positive_regulation of Transcription of Aqp3 1 0.29 0.21 0.09 14.72
149 INT260945 Mapk14 Positive_regulation of Gene_expression of Aqp3 1 0.29 0.21 0.09 14.72
150 INT174503 Binding of HLA-B and KIR3DL1 6 0.37 3.48 1.61 14.00
151 INT260947 Mapk14 Positive_regulation of Aqp3 1 0.29 0.21 0.09 13.36
152 INT328936 Binding of HLA-B and KIR3DS1 1 0.25 0.7 0.48 12.80
153 INT191816 Binding of ETFA and TGM2 1 0.01 0.66 0 11.76
154 INT179502 Binding of Cd14 and Tlr4 29 0.39 13.77 5.73 11.40
155 INT249962 Binding of KIT and KITLG 6 0.19 3.69 0.17 9.80
156 INT233279 Binding of TLX1 and Tgif1 1 0.00 0.05 0 8.56
157 INT272523 Binding of DMPK and Gtf3a 1 0.00 0.81 0 8.00
158 INT272521 Binding of DMPK and Nkx2-5 1 0.01 0.42 0 8.00
159 INT237924 PTPN1 Regulation of Gene_expression of CFLAR 1 0.01 0.7 0.19 6.88
160 INT266764 TPSD1 Positive_regulation of F2RL1 Positive_regulation of Localization of SFTPA1 1 0.00 1.55 1.76 6.32
161 INT189796 Binding of EHHADH and Cd14 1 0.13 0.9 0.14 6.12
162 INT182635 Binding of CCR5 and CCL5 2 0.09 4.19 3 5.00
163 INT86180 SFTPA1 Positive_regulation of Localization of IL6 2 0.06 2.01 2.85 5.00
164 INT175329 Binding of ICAM1 and ITGAL 14 0.18 10.06 2.81 5.00
165 INT113550 Binding of FN1 and VTN 6 0.30 5.24 1.91 5.00
166 INT147108 TGFB1 Positive_regulation of Gene_expression of FN1 4 0.47 1.01 1.63 5.00
167 INT266768 NGF Positive_regulation of Localization of SFTPA1 1 0.01 1.65 1.6 5.00
168 INT266767 SFTPA1 Positive_regulation of Gene_expression of TNF 1 0.01 1.69 1.59 5.00
169 INT208991 Binding of CALM1 and Ca2 10 0.06 1.34 1.55 5.00
170 INT238005 Binding of Cxcr3 and Cxcl10 2 0.38 3.73 1.42 5.00
171 INT19633 GNRH1 Regulation of Localization of CGA 4 0.44 0.82 1.33 5.00
172 INT173059 Binding of KDR and VEGFA 43 0.43 29.63 1.1 5.00
173 INT323175 PRKCA Positive_regulation of Akt1 1 0.02 0 1.1 5.00
174 INT182125 Binding of CD14 and TLR4 7 0.25 3.78 1.03 5.00
175 INT181450 Binding of Ccr5 and Ccl3 4 0.18 2.19 1.03 5.00
176 INT252602 Binding of Cxcl10 and Ppig 1 0.08 1.55 0.96 5.00
177 INT232426 HRH2 Regulation of Localization of PRL 1 0.15 0.38 0.94 5.00
178 INT114883 Akt1 Regulation of Pik3r1 2 0.16 0.65 0.92 5.00
179 INT183269 Binding of CEBPB and CPOX 1 0.07 1.61 0.89 5.00
180 INT209881 Binding of TNFRSF11B and TNFSF11 8 0.36 8.92 0.86 5.00
181 INT249656 tm Positive_regulation of Il12a 1 0.07 1.17 0.84 5.00
182 INT182636 Binding of TNFSF11 and TNFRSF11A 16 0.29 17.5 0.84 5.00
183 INT105435 TNF Positive_regulation of IL6 5 0.25 4.45 0.83 5.00
184 INT316544 BCL2L11 Regulation of INS 1 0.00 1.36 0.77 5.00
185 INT152429 Ghrh Positive_regulation of Localization of Gh 4 0.37 0.56 0.75 5.00
186 INT123229 OXTR Regulation of Localization of PRL 2 0.30 0 0.73 5.00
187 INT266769 IL2 Positive_regulation of Localization of IL4 1 0.00 1.03 0.72 5.00
188 INT213726 Binding of Ngfr and Ntrk1 1 0.14 0.96 0.72 5.00
189 INT317585 Binding of Lbp and Ppap2b 1 0.03 0.78 0.72 5.00
190 INT317586 Binding of SCLY and Ppap2b 1 0.00 0.78 0.72 5.00
191 INT266765 IL2 Positive_regulation of Localization of IL10 1 0.01 1.03 0.72 5.00
192 INT257745 SAGE1 Positive_regulation of AXL 1 0.07 1.96 0.69 5.00
193 INT215098 Tlr4 Positive_regulation of Localization of Il6 3 0.18 1.18 0.69 5.00
194 INT28947 GH1 Positive_regulation of Gene_expression of IGF1 4 0.22 3.78 0.69 5.00
195 INT291552 Binding of Dlat and Sec22b 1 0.01 0.95 0.67 5.00
196 INT291548 Binding of Gper and Sec22b 1 0.02 0.94 0.67 5.00
197 INT312105 ELANE Positive_regulation of Localization of PTGER2 4 0.03 1.3 0.64 5.00
198 INT25248 GNRH1 Regulation of CGA 4 0.30 1.22 0.62 5.00
199 INT302469 F2 Positive_regulation of Gene_expression of MMP9 1 0.01 1.82 0.62 5.00
200 INT89902 SST Positive_regulation of Localization of PRL 2 0.40 0 0.61 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Reprotox - General 3. They are ordered first by their pain relevance and then by number of times they were reported in Reprotox - General 3. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT47909 Binding of CPP 32 0.48 24.9 13.79 100.00
2 INT1108 Gene_expression of PPY 58 0.75 36.57 10.76 100.00
3 INT3180 Positive_regulation of PPY 39 0.63 25.57 10.15 100.00
4 INT141665 Gene_expression of AGRP 83 0.67 43.43 4.24 100.00
5 INT6782 Gene_expression of SCN5A 156 0.78 33.13 17.88 100.00
6 INT239083 Binding of PPY 9 0.32 7.59 2.9 100.00
7 INT22022 Regulation of PPY 8 0.26 5.52 5.02 100.00
8 INT11831 Positive_regulation of pid 13 0.40 23.37 1.54 100.00
9 INT18893 Positive_regulation of CPP 81 0.69 38.03 34.33 100.00
10 INT15470 Regulation of CPP 42 0.48 26.1 18.25 100.00
11 INT8547 Gene_expression of MUC16 116 0.78 75.97 12.18 100.00
12 INT176562 Regulation of Lck 1 0.02 1.14 0 100.00
13 INT103463 Localization of CPP 16 0.66 9.63 4.08 100.00
14 INT340382 Regulation of Regulation of PPY 1 0.12 0.94 0.94 100.00
15 INT18894 Gene_expression of CPP 44 0.77 23.05 23.05 100.00
16 INT145097 Negative_regulation of Pain1 16 0.22 19.11 16.82 100.00
17 INT216858 Negative_regulation of PID1 4 0.35 6.3 1.11 100.00
18 INT251079 Gene_expression of G0s2 32 0.77 36.32 2.01 100.00
19 INT126030 Regulation of CFD 4 0.21 3.92 0.83 100.00
20 INT194023 Gene_expression of RQCD1 3 0.52 3.99 0.12 100.00
21 INT22798 Regulation of Shbg 64 0.60 26.71 8.76 100.00
22 INT251078 Positive_regulation of Gene_expression of G0s2 8 0.69 8.1 0.57 100.00
23 INT4682 Positive_regulation of EGOT 2 0.42 2.32 1.28 100.00
24 INT3598 Regulation of Pla2g1b 12 0.44 3.45 3.9 100.00
25 INT38672 Binding of KRT20 69 0.39 48.01 6.31 100.00
26 INT197024 Binding of STIP1 11 0.35 10.84 0.52 100.00
27 INT187728 Regulation of PCOS1 1 0.02 0.84 0.13 100.00
28 INT185407 Binding of PER1 13 0.42 9.32 2.6 99.98
29 INT121752 Gene_expression of IL11 54 0.62 18.05 7.16 99.98
30 INT11506 Binding of MUC16 20 0.48 22.89 1.03 99.98
31 INT174727 Positive_regulation of Positive_regulation of ESR1 14 0.44 6.3 2.7 99.98
32 INT4485 Negative_regulation of Positive_regulation of PRL 11 0.43 4.24 3.89 99.96
33 INT46559 Gene_expression of pid 11 0.58 13.1 1.93 99.92
34 INT7975 Regulation of PLOD1 97 0.62 20.9 30.51 99.92
35 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 99.92
36 INT7205 Positive_regulation of HBG1 65 0.69 40.35 6.37 99.92
37 INT14724 Negative_regulation of CYP19A1 233 0.59 96.56 18.26 99.84
38 INT104979 Gene_expression of MITF 51 0.62 54.83 6.91 99.84
39 INT8546 Positive_regulation of MUC16 99 0.69 74.98 11.26 99.84
40 INT155609 Phosphorylation of pid 2 0.54 3.15 1.62 99.84
41 INT81796 Binding of AGRP 62 0.36 37.19 5.3 99.84
42 INT187717 Regulation of Negative_regulation of CYP19A1 11 0.42 2.85 0.45 99.84
43 INT217807 Regulation of MITF 20 0.00 18.57 0.36 99.84
44 INT34777 Localization of IGF1 82 0.80 42.68 8.62 99.84
45 INT300380 Localization of HMGA1 1 0.43 1.75 0 99.84
46 INT300344 Localization of HMGA2 1 0.42 1.75 0 99.84
47 INT671 Positive_regulation of Cea 221 0.69 164.5 47.79 99.84
48 INT36133 Binding of pid 22 0.42 31.34 4.1 99.80
49 INT17881 Gene_expression of LEP 278 0.78 221.61 48.31 99.80
50 INT126743 Positive_regulation of Gene_expression of LEP 61 0.66 50.02 11.17 99.80
51 INT71047 Gene_expression of CYP19A1 122 0.78 68.78 22.21 99.80
52 INT4145 Gene_expression of FSHR 124 0.77 44.98 13.04 99.78
53 INT197767 Positive_regulation of Negative_regulation of AGRP 1 0.45 1.26 0.04 99.78
54 INT197768 Positive_regulation of Localization of AGRP 2 0.48 1.75 0.04 99.78
55 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 99.76
56 INT1644 Regulation of FSHR 77 0.55 15.62 21.49 99.76
57 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 99.76
58 INT75907 Binding of LEP 53 0.46 46.65 8.44 99.76
59 INT56177 Regulation of pid 1 0.23 1.48 0.56 99.76
60 INT341698 Localization of pid 1 0.06 0.88 0.05 99.76
61 INT94464 Negative_regulation of Hand1 44 0.41 31.5 12.39 99.74
62 INT268656 Binding of CLDN4 1 0.47 0.88 0.11 99.70
63 INT167679 Gene_expression of Ccr5 74 0.75 59.03 18.16 99.64
64 INT334924 Binding of MEHMO 1 0.01 9.69 0.26 99.64
65 INT985 Negative_regulation of GH1 213 0.57 89.53 32.39 99.60
66 INT179831 Negative_regulation of Gene_expression of Il11 6 0.41 1.92 1.14 99.60
67 INT10139 Positive_regulation of F13A1 64 0.56 44.75 9.69 99.58
68 INT81795 Negative_regulation of AGRP 23 0.41 10.93 0.87 99.56
69 INT65856 Positive_regulation of TP53 138 0.67 112.65 16.71 99.54
70 INT102816 Positive_regulation of TCEAL1 6 0.37 7.08 0.96 99.54
71 INT82434 Positive_regulation of LEP 117 0.70 95.45 20.22 99.52
72 INT39532 Negative_regulation of Hrh2 7 0.43 7.5 9.4 99.52
73 INT1512 Binding of Prl 73 0.48 26.22 20.63 99.52
74 INT15888 Positive_regulation of Nbr1 42 0.69 35.76 10.48 99.50
75 INT823 Negative_regulation of ESR1 144 0.58 63.72 22.52 99.48
76 INT92470 Negative_regulation of Gene_expression of CCL5 15 0.50 5.46 5.86 99.48
77 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83 99.44
78 INT74563 Positive_regulation of Gene_expression of ROS1 258 0.61 168.18 34.08 99.44
79 INT69437 Positive_regulation of ROS1 328 0.58 222.83 40.56 99.44
80 INT9954 Negative_regulation of Hrh1 16 0.52 13.04 11.76 99.40
81 INT2543 Positive_regulation of Calca 787 0.70 331.13 592.08 99.40
82 INT179826 Gene_expression of Il11 29 0.75 11.5 3.75 99.40
83 INT1273 Gene_expression of Avp 356 0.78 90.56 138.7 99.40
84 INT477 Localization of Avp 813 0.81 131.58 300.4 99.40
85 INT251 Regulation of INS 398 0.62 232.47 55.04 99.40
86 INT119904 Regulation of CYP19A1 25 0.62 9.36 8.34 99.36
87 INT217152 Gene_expression of MIR145 4 0.43 5.15 0.29 99.36
88 INT300352 Positive_regulation of Gene_expression of MIR145 1 0.20 1.68 0 99.36
89 INT300346 Positive_regulation of Gene_expression of MIR197 1 0.15 1.68 0 99.36
90 INT300350 Gene_expression of MIR197 1 0.23 1.68 0 99.36
91 INT300367 Gene_expression of MIR411 1 0.18 1.67 0 99.36
92 INT300354 Positive_regulation of Gene_expression of MIR411 1 0.11 1.67 0 99.36
93 INT300361 Gene_expression of MIR412 1 0.19 1.61 0 99.36
94 INT300359 Positive_regulation of Gene_expression of MIR412 1 0.12 1.61 0 99.36
95 INT56299 Transcription of IL4 15 0.64 10.2 5.44 99.36
96 INT18011 Positive_regulation of HP 60 0.50 31.88 4.75 99.36
97 INT35584 Binding of ACLY 22 0.35 31.78 7.17 99.36
98 INT81799 Negative_regulation of Binding of AGRP 5 0.42 1.13 0.63 99.34
99 INT27627 Binding of Rac1 41 0.41 22.88 13.68 99.32
100 INT18445 Regulation of Transcription of Insr 1 0.12 0.84 0.63 99.32
101 INT2111 Gene_expression of LIF 34 0.77 16.82 6.76 99.30
102 INT172186 Gene_expression of IL6ST 20 0.75 11.63 2.67 99.30
103 INT352832 Regulation of Miox 1 0.00 0.51 0.05 99.30
104 INT10841 Positive_regulation of Gene_expression of Gh 101 0.59 45.39 16.96 99.26
105 INT2056 Negative_regulation of Gnrh1 175 0.59 33.43 63.32 99.24
106 INT3448 Positive_regulation of Gh 521 0.69 180.03 161.18 99.24
107 INT17217 Regulation of Negative_regulation of Gnrh1 5 0.31 2.56 3.78 99.24
108 INT155 Positive_regulation of Prl 1233 0.70 317.93 457.82 99.20
109 INT78899 Gene_expression of CCL5 155 0.77 84.02 55.09 99.20
110 INT159777 Regulation of Negative_regulation of Shbg 2 0.41 1.54 0.36 99.20
111 INT213203 Regulation of Localization of Shbg 2 0.29 0.91 0.28 99.20
112 INT5130 Regulation of GNRH1 139 0.62 31.95 42.08 99.16
113 INT915 Positive_regulation of PRL 342 0.70 141.96 104.31 99.16
114 INT252562 Positive_regulation of Sae1 1 0.03 3.4 0.99 99.14
115 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 99.12
116 INT94784 Binding of ROS1 113 0.40 71.57 10.26 99.12
117 INT300381 Regulation of MARCKS 1 0.18 1.9 0.07 99.12
118 INT300363 Positive_regulation of Regulation of MARCKS 1 0.13 1.9 0.07 99.12
119 INT18446 Transcription of Insr 2 0.18 0.84 0.62 99.10
120 INT146693 Gene_expression of Mbl1 17 0.59 10.99 3.13 99.08
121 INT1497 Negative_regulation of Gh 415 0.59 192.95 74.71 99.06
122 INT1498 Gene_expression of Gh 521 0.75 220.84 81.16 99.06
123 INT65892 Negative_regulation of Binding of Gh 8 0.32 3.61 1.38 99.06
124 INT28861 Binding of Gh 61 0.46 25.61 6.38 99.06
125 INT1499 Negative_regulation of Gene_expression of Gh 58 0.42 25.17 7.86 99.06
126 INT7035 Regulation of CGA 87 0.45 29.04 28.45 99.04
127 INT62124 Gene_expression of NOS1 444 0.78 218.08 114.85 99.00
128 INT64113 Positive_regulation of Gene_expression of NOS1 110 0.60 71.03 29.72 99.00
129 INT179169 Transcription of IL13 11 0.15 4.22 1.37 99.00
130 INT125832 Regulation of TTPA 3 0.05 1.33 0.08 99.00
131 INT14043 Binding of HP 52 0.30 26.56 7.76 99.00
132 INT72949 Binding of Mif 31 0.46 23.12 11.65 99.00
133 INT49319 Regulation of Hrh2 5 0.45 2.31 5.04 98.98
134 INT9988 Regulation of Hrh1 22 0.46 12.87 22.13 98.98
135 INT34729 Positive_regulation of IFN1@ 233 0.67 128.04 30.38 98.96
136 INT154527 Gene_expression of POU5F1 180 0.78 34.01 4.34 98.96
137 INT193401 Binding of UNC5B 1 0.04 0.29 0.08 98.96
138 INT7581 Binding of ADHD1 132 0.46 135.1 19.73 98.96
139 INT11728 Binding of NUPL2 3 0.47 3.28 0.42 98.96
140 INT85245 Positive_regulation of PID1 2 0.16 2.55 0.29 98.94
141 INT9082 Positive_regulation of ESR1 238 0.69 148.51 36.69 98.90
142 INT217823 Positive_regulation of Gene_expression of MITF 8 0.01 7.1 0.55 98.88
143 INT4629 Regulation of Fshb 12 0.49 1.93 5.95 98.88
144 INT2055 Regulation of Gnrh1 185 0.62 23.65 71.26 98.88
145 INT416 Regulation of LH 253 0.62 31.48 125.55 98.88
146 INT90938 Gene_expression of Eng 48 0.72 15.76 1.24 98.88
147 INT28885 Regulation of Tk1 6 0.47 2.53 0.82 98.88
148 INT185220 Regulation of EBAG9 2 0.27 2.74 0.56 98.88
149 INT5135 Negative_regulation of GNRH1 106 0.58 36.63 27.71 98.86
150 INT203 Positive_regulation of Pomc 257 0.70 90.56 92.84 98.86
151 INT23010 Positive_regulation of CYP19A1 28 0.58 24.18 5.37 98.84
152 INT171105 Positive_regulation of Positive_regulation of CYP19A1 5 0.39 4.02 0.58 98.84
153 INT187718 Negative_regulation of Positive_regulation of CYP19A1 1 0.33 0.61 0.05 98.84
154 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 98.84
155 INT10100 Binding of ELANE 22 0.47 15.32 5.19 98.84
156 INT187720 Negative_regulation of Negative_regulation of CYP19A1 5 0.34 0.99 0 98.84
157 INT917 Positive_regulation of Localization of PLOD1 51 0.69 8.53 22.87 98.76
158 INT179830 Negative_regulation of Il11 5 0.41 2.87 1.87 98.76
159 INT270543 Binding of Get4 1 0.25 0.52 0 98.76
160 INT18357 Gene_expression of TRPV1 825 0.78 307.11 382.81 98.72
161 INT119641 Gene_expression of EBAG9 25 0.76 33.2 3.96 98.68
162 INT194022 Negative_regulation of RQCD1 4 0.33 3.18 0.13 98.60
163 INT19059 Gene_expression of RLN1 5 0.75 1.76 1.28 98.60
164 INT171091 Positive_regulation of SLC10A4 8 0.16 6.27 0.99 98.60
165 INT188754 Localization of AGRP 15 0.74 8.88 0.6 98.58
166 INT16167 Negative_regulation of DMD 186 0.57 108.71 15.25 98.50
167 INT16235 Positive_regulation of CGB 27 0.70 15.71 4.06 98.50
168 INT51150 Positive_regulation of HTC2 10 0.67 6.8 2.95 98.50
169 INT8903 Gene_expression of IFNA2 58 0.71 38.23 8.68 98.48
170 INT48593 Positive_regulation of NOS1 420 0.68 226.15 114.71 98.40
171 INT9381 Positive_regulation of TRPV1 523 0.70 187.4 276.05 98.36
172 INT73502 Positive_regulation of IL10 154 0.69 124.87 43.5 98.32
173 INT69439 Regulation of ROS1 46 0.45 31.22 6.94 98.32
174 INT73500 Regulation of IL13 12 0.36 10.37 3.53 98.32
175 INT36132 Negative_regulation of pid 12 0.43 15.15 1.73 98.30
176 INT1624 Gene_expression of Cea 212 0.76 180.44 34.21 98.24
177 INT28865 Positive_regulation of Gene_expression of Cea 21 0.57 15.03 2.52 98.24
178 INT920 Localization of PLOD1 223 0.81 42.25 78.7 98.20
179 INT912 Localization of FSHR 91 0.79 23.61 15.58 98.20
180 INT221127 Positive_regulation of IGKV1-22 2 0.17 4.7 1.93 98.20
181 INT1792 Positive_regulation of CGA 123 0.70 64.73 20.79 98.16
182 INT55344 Gene_expression of Ros1 396 0.54 217.64 59.98 98.16
183 INT72060 Positive_regulation of Gene_expression of Ros1 127 0.41 76.76 20.91 98.16
184 INT217224 Regulation of TPM1 2 0.34 2.9 0.07 98.16
185 INT2386 Gene_expression of Pgr 112 0.78 45.46 22.19 98.04
186 INT31333 Gene_expression of Esr2 19 0.69 8.78 6.83 98.04
187 INT170332 Gene_expression of IFN1@ 477 0.75 275.21 69.65 98.00
188 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 98.00
189 INT192409 Positive_regulation of Gene_expression of IFN1@ 102 0.67 64.66 18.8 98.00
190 INT89580 Negative_regulation of STAR 16 0.35 14.88 0.2 98.00
191 INT17275 Gene_expression of HIVEP1 267 0.75 232.07 24.06 97.98
192 INT528 Gene_expression of Prl 693 0.78 217.18 192.2 97.96
193 INT2139 Negative_regulation of Cea 55 0.43 43.59 9.14 97.96
194 INT720 Positive_regulation of POMC 807 0.70 237.37 353.83 97.88
195 INT122399 Binding of Hrh2 3 0.38 1.27 1.64 97.84
196 INT203646 Gene_expression of STIP1 26 0.63 23.57 1.14 97.80
197 INT32324 Gene_expression of Eda 20 0.75 6.43 4.66 97.76
198 INT17453 Localization of Dlst 20 0.59 4.54 1.46 97.72
199 INT2614 Gene_expression of CGA 187 0.78 105.89 24.77 97.68
200 INT97465 Regulation of PDCD4 3 0.37 3.68 0.24 97.68
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