D:Respiratory Disease

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Disease Term
Synonyms Byssinosis, Disease Of Respiratory System, DISEASE SYNDROME OF RESPIRATORY SYSTEM, Diseases Syndromes Of Respiratory System, Fh Respiratory Disease, Occupational Respiratory Disease, Occupational Respiratory Diseases, RESPIRATORY DISEASES, RESPIRATORY DISORDER, RESPIRATORY SYSTEM DISORDER, Respiratory Tract Diseases
Documents 951
Hot Single Events 200
Hot Interactions 6

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Respiratory Disease. They are ordered first by their relevance to Respiratory Disease and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT101942 Binding of CD40 and CD40LG 16 0.23 15.24 4.01 91.72
2 INT341816 Binding of CEP68 and Aia1 1 0.02 4.76 0.76 85.96
3 INT341794 Binding of SUGT1 and CEP68 1 0.00 1.1 0.33 85.96
4 INT190827 KCNA1 Regulation of Localization of MUC1 1 0.05 0.08 0.22 83.80
5 INT334500 Binding of IGHE and SPARCL1 1 0.01 1.47 0.55 80.52
6 INT341818 Binding of PITX2 and Aia1 1 0.00 0.53 0.16 80.44
7 INT341813 Binding of SUGT1 and Aia1 1 0.00 0.48 0.16 79.88
8 INT228739 Il4 Positive_regulation of Gene_expression of Ccl17 1 0.14 0.66 0.39 79.52
9 INT228761 Tnf Positive_regulation of Gene_expression of Ccl17 1 0.20 0.66 0.39 79.52
10 INT284563 Tlr3 Positive_regulation of Mat1a 1 0.22 2.43 0 71.48
11 INT284566 Tlr3 Positive_regulation of Mthfd1 1 0.17 2.43 0 71.48
12 INT194383 Il13 Positive_regulation of Gene_expression of Il4 1 0.00 1.75 0.13 63.40
13 INT247578 Hif1a Regulation of VEGFA 1 0.02 1.59 0.07 59.92
14 INT190147 MMP12 Positive_regulation of MMP2 Positive_regulation of Protein_catabolism of MMRN1 1 0.03 0.87 0.9 59.76
15 INT334497 Positive_regulation of IGHG3 Positive_regulation of IGHE 1 0.01 0.81 0.04 59.60
16 INT334496 IGHG3 Positive_regulation of IGHE 1 0.01 0.75 0.04 58.60
17 INT352217 Tlr4 Positive_regulation of Binding of Tbce 1 0.03 0.8 0.07 55.68
18 INT190165 MMP12 Positive_regulation of MMP2 1 0.13 0.72 0.85 55.36
19 INT217620 Dep1 Positive_regulation of Gene_expression of Tlr4 1 0.20 0.4 0.12 50.00
20 INT244688 Binding of Mmp16 and Mmp2 1 0.31 0.69 0 45.72
21 INT211105 Binding of CRS and IGHE 1 0.02 3.63 0.66 39.76
22 INT190826 ELANE Positive_regulation of Localization of MUC1 1 0.07 0 0.29 36.32
23 INT312819 IL5 Regulation of Il13 1 0.00 1.55 0.18 29.48
24 INT122710 GUCA2A Positive_regulation of RTCA 1 0.03 0.16 0.05 25.00
25 INT122713 Guca2b Positive_regulation of RTCA 1 0.03 0.16 0.05 25.00
26 INT327386 TNF Regulation of Gene_expression of Oxtr 1 0.20 0.98 0.45 20.08
27 INT327381 Il13 Regulation of Gene_expression of Oxtr 1 0.37 0.88 0.35 19.44
28 INT180984 IRF6 Positive_regulation of Localization of IL8 7 0.11 2.13 3.47 5.00
29 INT190167 Binding of JUN and MMP12 1 0.26 0.82 2.76 5.00
30 INT178986 Binding of MMP9 and TIMP1 4 0.47 2.58 1.33 5.00
31 INT294775 IRF6 Positive_regulation of TLR4 6 0.08 2.04 1.32 5.00
32 INT173059 Binding of KDR and VEGFA 43 0.43 29.63 1.1 5.00
33 INT181450 Binding of Ccr5 and Ccl3 4 0.18 2.19 1.03 5.00
34 INT178663 Binding of CXCR3 and TH1L 2 0.04 2.24 1.01 5.00
35 INT54972 Binding of EDNRA and EDNRB 7 0.52 3.31 0.97 5.00
36 INT221386 Tlr4 Positive_regulation of Gene_expression of IL8 6 0.14 3.53 0.9 5.00
37 INT190183 MAPK1 Regulation of CDCP1 1 0.00 1.19 0.85 5.00
38 INT190168 BSG Regulation of CDCP1 1 0.00 1.18 0.84 5.00
39 INT190182 JUN Positive_regulation of MMP12 1 0.34 0.08 0.8 5.00
40 INT181616 INS Positive_regulation of IRS1 1 0.01 1 0.79 5.00
41 INT181615 SRC Positive_regulation of IRS1 1 0.01 0.98 0.77 5.00
42 INT221415 IRF6 Positive_regulation of Gene_expression of IL10 2 0.05 1.73 0.75 5.00
43 INT152429 Ghrh Positive_regulation of Localization of Gh 4 0.37 0.56 0.75 5.00
44 INT190174 TNF Positive_regulation of MMP12 1 0.27 0.08 0.74 5.00
45 INT190169 Regulation of JUN Positive_regulation of Localization of MMP12 1 0.30 0.07 0.74 5.00
46 INT142847 IRF6 Positive_regulation of IL6 5 0.07 1.09 0.73 5.00
47 INT275554 Binding of CXCL10 and Cxcr3 1 0.03 2.18 0.71 5.00
48 INT185802 Binding of MMP7 and SPP1 1 0.33 1.71 0.68 5.00
49 INT190177 Gene_expression of IL13 Regulation of Gene_expression of IL4 1 0.04 0.05 0.68 5.00
50 INT190172 Gene_expression of IL13 Regulation of MMP12 1 0.12 0.05 0.68 5.00
51 INT190171 Gene_expression of IL4 Regulation of Gene_expression of IL13 1 0.04 0.05 0.68 5.00
52 INT190164 Gene_expression of IL4 Regulation of MMP12 1 0.11 0.05 0.68 5.00
53 INT278827 Binding of EDN1 and EDNRB 3 0.17 2.7 0.67 5.00
54 INT203758 Binding of IL6 and TNF 3 0.26 2.03 0.67 5.00
55 INT190178 PIK3CG Regulation of MMP12 1 0.09 0 0.65 5.00
56 INT190211 Adm Regulation of MMP12 1 0.29 0 0.65 5.00
57 INT244320 Tlr4 Positive_regulation of Aliq1 3 0.04 4.51 0.64 5.00
58 INT178097 Binding of EDN1 and EDNRA 7 0.21 5.97 0.62 5.00
59 INT190170 IL4 Regulation of Gene_expression of IL13 1 0.04 0 0.62 5.00
60 INT190175 IL13 Regulation of Gene_expression of IL4 1 0.04 0 0.62 5.00
61 INT190180 IL4 Regulation of MMP12 1 0.11 0 0.6 5.00
62 INT274167 Il13 Regulation of Il5 2 0.09 2.05 0.59 5.00
63 INT190166 IL13 Regulation of MMP12 1 0.12 0 0.59 5.00
64 INT275552 Tlr4 Positive_regulation of Gene_expression of Il1 1 0.00 1.28 0.59 5.00
65 INT181619 ACE Positive_regulation of KNG1 1 0.33 0.97 0.58 5.00
66 INT190145 Binding of JUN and MMP12 Positive_regulation of Positive_regulation of PIK3CA 1 0.01 0.57 0.57 5.00
67 INT190146 Positive_regulation of PIK3CA Positive_regulation of Binding of JUN and MMP12 1 0.01 0.57 0.57 5.00
68 INT335995 Il10 Negative_regulation of Tgfb1 1 0.06 0.83 0.57 5.00
69 INT190148 Binding of JUN and MMP12 Positive_regulation of MMP12 1 0.33 0.57 0.57 5.00
70 INT185809 Binding of PDX1 and SPP1 1 0.02 1.69 0.57 5.00
71 INT190181 Positive_regulation of PIK3CA Positive_regulation of MMP12 1 0.01 0.54 0.56 5.00
72 INT156667 Gh Positive_regulation of Gene_expression of Igf1 6 0.28 0.88 0.56 5.00
73 INT244232 Binding of Ccr5 and Ccl4 3 0.17 1.48 0.55 5.00
74 INT278824 Positive_regulation of Binding of EDNRA and EDNRB 1 0.12 1.65 0.53 5.00
75 INT278819 EDNRA Negative_regulation of Binding of EDNRA and EDNRB 1 0.04 1.65 0.53 5.00
76 INT274170 Il13 Regulation of Il4 3 0.09 2.75 0.51 5.00
77 INT185800 SPP1 Negative_regulation of Gene_expression of MMP1 1 0.26 1.03 0.49 5.00
78 INT186713 IK Positive_regulation of Gene_expression of NOS1 1 0.00 0.55 0.49 5.00
79 INT278825 Positive_regulation of Binding of EDN1 and EDNRB 3 0.16 1.24 0.49 5.00
80 INT193480 Binding of ABCA1 and IRF6 1 0.00 1.08 0.46 5.00
81 INT275549 Il10 Positive_regulation of Localization of Hand2 1 0.01 1.3 0.46 5.00
82 INT275550 Hand1 Positive_regulation of Localization of Hand2 1 0.00 1.29 0.46 5.00
83 INT302421 IFNA1 Positive_regulation of Cxcl10 1 0.02 1.8 0.45 5.00
84 INT302422 IFNA1 Positive_regulation of Cxcl9 1 0.03 1.81 0.45 5.00
85 INT186711 IK Positive_regulation of Localization of IL8 1 0.00 0.39 0.44 5.00
86 INT302423 Etohi5 Positive_regulation of IFNA1 1 0.00 1.77 0.44 5.00
87 INT178664 Binding of CCR5 and TH1L 1 0.04 1.04 0.44 5.00
88 INT228732 Il13 Regulation of Gene_expression of Il5 1 0.15 0.44 0.44 5.00
89 INT335996 Mmp8 Regulation of Protein_catabolism of MIP 1 0.44 1.06 0.43 5.00
90 INT347563 Abat Positive_regulation of Gopc 1 0.04 0.2 0.43 5.00
91 INT201092 Binding of KNG1 and NGF 1 0.00 0.31 0.43 5.00
92 INT201120 Binding of KNG1 and Par2 1 0.00 0.3 0.42 5.00
93 INT259637 Binding of Mmp12 and COPD 2 0.02 1.71 0.4 5.00
94 INT294780 IL6 Positive_regulation of IL10 2 0.10 1.26 0.39 5.00
95 INT186758 Il13 Regulation of Ccl5 2 0.17 0.17 0.39 5.00
96 INT186757 Il13 Regulation of Ccl11 2 0.21 0.17 0.39 5.00
97 INT185811 SPP1 Positive_regulation of MMP3 1 0.14 0.83 0.38 5.00
98 INT185814 Binding of MMP3 and SPP1 1 0.15 0.83 0.38 5.00
99 INT169507 Oxt Regulation of Gene_expression of Oxtr 2 0.20 0.84 0.38 5.00
100 INT179938 Negative_regulation of Mapk8 Negative_regulation of TNF 1 0.02 1.09 0.37 5.00
101 INT185804 MMP2 Positive_regulation of SPP1 1 0.15 0.88 0.37 5.00
102 INT185795 MMP7 Positive_regulation of SPP1 1 0.38 0.81 0.37 5.00
103 INT335994 Timp1 Regulation of Col7a1 1 0.01 0.36 0.37 5.00
104 INT340850 Binding of IGHE and Baat 1 0.07 0.27 0.37 5.00
105 INT185798 SPP1 Positive_regulation of Gene_expression of MMP2 1 0.26 0.87 0.37 5.00
106 INT186769 Dep1 Positive_regulation of Gene_expression of IgG 2 0.03 1.3 0.36 5.00
107 INT185807 SPP1 Positive_regulation of MMP7 1 0.56 0.79 0.36 5.00
108 INT178662 IFN1@ Positive_regulation of CXCL9 1 0.20 0.5 0.36 5.00
109 INT133307 Binding of CD44 and SPP1 5 0.26 2.6 0.35 5.00
110 INT275557 Negative_regulation of Binding of CXCL10 and Cxcr3 1 0.04 1.09 0.35 5.00
111 INT190173 BSG Regulation of MMRN1 1 0.00 0.29 0.35 5.00
112 INT288537 Binding of Ccr3 and Ccl11 1 0.17 2.92 0.35 5.00
113 INT278820 EDNRA Negative_regulation of Binding of EDN1 and EDNRB 1 0.03 1.1 0.35 5.00
114 INT352547 Binding of CFTR and DMD 1 0.01 1.42 0.35 5.00
115 INT174266 TNF Regulation of Gene_expression of F3 1 0.00 3.2 0.33 5.00
116 INT228759 Rae1 Negative_regulation of Il5 1 0.09 1.32 0.33 5.00
117 INT174265 IL18 Regulation of Gene_expression of F3 1 0.00 3.21 0.33 5.00
118 INT325221 Il13 Regulation of Ccl3 1 0.08 0.17 0.32 5.00
119 INT327380 Il13 Positive_regulation of Oxt 1 0.29 0.13 0.32 5.00
120 INT347562 Abat Positive_regulation of Mki67 1 0.03 0 0.3 5.00
121 INT325220 Il13 Negative_regulation of Ccl11 1 0.29 0.65 0.3 5.00
122 INT272925 Ccl2 Positive_regulation of Gene_expression of Col7a1 1 0.00 0.72 0.3 5.00
123 INT333398 CFD Negative_regulation of Gene_expression of Pdgfa 1 0.02 0.64 0.3 5.00
124 INT275555 Binding of Ltb4r1 and COPD 1 0.01 1.02 0.3 5.00
125 INT272932 Binding of Mmp9 and COPD 1 0.01 0.78 0.29 5.00
126 INT334499 Binding of AMELX and IL4 1 0.12 0.47 0.29 5.00
127 INT185799 Binding of EGFR and SPP1 1 0.19 0.64 0.29 5.00
128 INT272930 Positive_regulation of Binding of Mmp1a and COPD 1 0.01 0.79 0.29 5.00
129 INT327379 S100a8 Regulation of Oxt 1 0.00 0.95 0.29 5.00
130 INT272933 Binding of Mmp1a and COPD 1 0.01 0.78 0.29 5.00
131 INT272929 Positive_regulation of Binding of Mmp9 and COPD 1 0.01 0.79 0.29 5.00
132 INT228734 Rae1 Negative_regulation of Il4 1 0.08 0.68 0.29 5.00
133 INT272928 Positive_regulation of Binding of Mmp12 and COPD 1 0.01 0.79 0.29 5.00
134 INT185806 Binding of PDX1 and MMP7 1 0.02 0.84 0.28 5.00
135 INT185813 Binding of MMP7 and Positive_regulation of SPP1 1 0.46 0.85 0.28 5.00
136 INT185818 SPP1 Positive_regulation of Gene_expression of COL7A1 1 0.10 0.82 0.28 5.00
137 INT275548 Il10 Regulation of Mmp9 1 0.00 0.86 0.28 5.00
138 INT274172 Negative_regulation of Pde4a Negative_regulation of Positive_regulation of TNF 1 0.02 0.72 0.28 5.00
139 INT275556 Il10 Positive_regulation of Gene_expression of TIMP1 1 0.00 0.85 0.28 5.00
140 INT193479 TLR2 Regulation of Binding of IRF6 1 0.04 0.75 0.28 5.00
141 INT275509 IL8 Positive_regulation of Gene_expression of TIMP1 1 0.00 0.85 0.28 5.00
142 INT191718 Binding of FLT1 and VEGFA 35 0.50 12.18 0.27 5.00
143 INT179928 Binding of Ephb1 and Mapk8 1 0.11 0.91 0.26 5.00
144 INT228752 Rae1 Negative_regulation of Hrec 1 0.01 0.32 0.26 5.00
145 INT228753 Rae1 Negative_regulation of Il13 1 0.10 0.32 0.26 5.00
146 INT275553 Negative_regulation of Binding of Ccr5 and Ccl3 1 0.05 0.73 0.26 5.00
147 INT244687 Mmp14 Positive_regulation of Mmp2 1 0.23 0.48 0.25 5.00
148 INT327387 TNF Positive_regulation of Oxtr 1 0.15 0.28 0.25 5.00
149 INT128644 Binding of Icam1 and Selp 2 0.39 0.57 0.25 5.00
150 INT180718 Binding of SARS and ACE2 3 0.12 7.76 0.25 5.00
151 INT327383 Il13 Positive_regulation of Gene_expression of Cd38 1 0.19 0 0.25 5.00
152 INT180982 SERPINC1 Negative_regulation of IRF6 Positive_regulation of IL6 1 0.00 0.54 0.24 5.00
153 INT202422 IL8 Positive_regulation of Localization of ELANE 1 0.02 0.91 0.24 5.00
154 INT333394 CFD Negative_regulation of Gene_expression of Cat 1 0.03 0.79 0.22 5.00
155 INT333397 CFD Negative_regulation of Gene_expression of Nos2 1 0.04 0.8 0.22 5.00
156 INT311872 IGHE Positive_regulation of Localization of Mmp9 1 0.01 1.35 0.22 5.00
157 INT181646 interleukin-17 Positive_regulation of ISYNA1 1 0.01 0.26 0.2 5.00
158 INT327382 Oxt Positive_regulation of Positive_regulation of Oxtr 1 0.30 0.41 0.2 5.00
159 INT310939 Binding of ELANE and COPD 1 0.08 1.51 0.2 5.00
160 INT181617 IL17A Positive_regulation of ISYNA1 1 0.01 0.27 0.2 5.00
161 INT310938 Binding of ELANE and HRCT1 1 0.02 1.5 0.2 5.00
162 INT179937 Trib3 Regulation of TNF 1 0.00 0.59 0.2 5.00
163 INT341814 Binding of CYSLTR1 and Aia1 1 0.01 1.33 0.19 5.00
164 INT268797 Ghrh Positive_regulation of Transcription of Gh 1 0.20 0.33 0.19 5.00
165 INT228737 Rae1 Negative_regulation of Hand2 1 0.08 1.07 0.19 5.00
166 INT179935 Binding of Jun and Mapk8 1 0.04 0.61 0.19 5.00
167 INT185805 SPP1 Regulation of MMP7 1 0.25 0.38 0.19 5.00
168 INT236307 SFTPD Positive_regulation of IGKV2D-38 1 0.03 0.57 0.18 5.00
169 INT185816 SPP1 Positive_regulation of Positive_regulation of MMP7 1 0.46 0.36 0.18 5.00
170 INT327385 Binding of TNF and Il13 1 0.09 0.6 0.18 5.00
171 INT186759 Dep1 Positive_regulation of Positive_regulation of IgG 1 0.01 0.62 0.18 5.00
172 INT278817 EDNRA Negative_regulation of Binding of EDN1 and EDNRA 1 0.02 0.55 0.18 5.00
173 INT272931 Binding of IL8 and Cxcr1 1 0.07 0.65 0.18 5.00
174 INT268279 Positive_regulation of Binding of Aggf1 and Alms1 1 0.02 0.15 0.18 5.00
175 INT268280 Binding of Aggf1 and Alms1 1 0.01 0.15 0.18 5.00
176 INT278818 EDNRA Negative_regulation of Binding of EDNRB and EDNRB 1 0.06 0.55 0.18 5.00
177 INT185803 Binding of MMP11 and SPP1 1 0.06 0.34 0.17 5.00
178 INT185815 Binding of MMP1 and SPP1 1 0.21 0.34 0.17 5.00
179 INT349475 Regulation of Bax Regulation of Bcl2 1 0.07 1.35 0.17 5.00
180 INT274168 Egf Positive_regulation of Gene_expression of Muc5ac 1 0.01 2.11 0.17 5.00
181 INT274169 Mapk1 Regulation of Pde4a 1 0.05 0.62 0.17 5.00
182 INT284558 Tlr4 Positive_regulation of Mat1a 1 0.14 0.24 0.17 5.00
183 INT185810 Binding of MMP2 and SPP1 1 0.14 0.34 0.17 5.00
184 INT310937 Binding of CD8A and COPD 1 0.16 1.21 0.16 5.00
185 INT203759 Binding of EDN1 and TNF 1 0.16 0.71 0.16 5.00
186 INT185808 SPP1 Positive_regulation of TIMP1 1 0.64 0.33 0.16 5.00
187 INT333393 CFD Positive_regulation of Gene_expression of Timp1 1 0.07 0.82 0.16 5.00
188 INT185793 SPP1 Positive_regulation of COL1A2 1 0.16 0.33 0.16 5.00
189 INT278828 Positive_regulation of Binding of EDN1 and EDNRA 1 0.06 0.51 0.15 5.00
190 INT341815 Binding of ADORA2A and Aia1 1 0.00 1.29 0.15 5.00
191 INT228751 Rae1 Regulation of Ccl24 1 0.04 0.32 0.15 5.00
192 INT349476 Bax Regulation of Bcl2 1 0.07 1.33 0.15 5.00
193 INT179934 Mapk8 Regulation of Gene_expression of Mmp9 1 0.06 0.48 0.15 5.00
194 INT179931 Ephb1 Regulation of Gene_expression of Mmp9 1 0.04 0.48 0.15 5.00
195 INT228757 Hspa9 Regulation of Ccl24 1 0.06 0.31 0.15 5.00
196 INT236303 Negative_regulation of IGKV2D-38 Positive_regulation of CRYGD 1 0.00 0.5 0.14 5.00
197 INT331628 Binding of HLA-DQA2 and Pain1 1 0.01 2.13 0.14 5.00
198 INT236316 IGKV2D-38 Positive_regulation of CRYGD 1 0.00 0.5 0.14 5.00
199 INT331627 Binding of HLA-DRB3 and Pain1 1 0.00 2.15 0.14 5.00
200 INT272927 Mapk14 Positive_regulation of Gene_expression of TNF 1 0.16 0.53 0.14 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Respiratory Disease. They are ordered first by their pain relevance and then by number of times they were reported in Respiratory Disease. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT234406 Localization of ADI1 2 0.06 4.52 0 100.00
2 INT131609 Binding of Tbxa2r 3 0.24 1.33 0.55 100.00
3 INT10372 Binding of ADI1 3 0.10 1.67 0.12 100.00
4 INT1322 Positive_regulation of Localization of INS 293 0.70 120.86 45.98 100.00
5 INT812 Localization of INS 1026 0.81 515.6 145.31 100.00
6 INT232667 Binding of Pd 17 0.16 20.76 3.58 100.00
7 INT341805 Binding of RAB1A 1 0.31 0.57 0.09 100.00
8 INT10228 Positive_regulation of PCS 49 0.67 28.72 7 99.90
9 INT1199 Positive_regulation of INS 579 0.70 399.64 50.43 99.90
10 INT33768 Positive_regulation of Cysltr1 87 0.46 54.66 33.52 99.84
11 INT3375 Gene_expression of IGHE 535 0.77 387.47 65.46 99.84
12 INT20425 Localization of Cpe 23 0.81 5.18 9.14 99.84
13 INT110020 Gene_expression of Mapk14 142 0.77 72.33 30.08 99.84
14 INT110023 Negative_regulation of Mapk14 127 0.59 84.27 45.42 99.84
15 INT244679 Binding of Mmp2 4 0.30 3.75 0.54 99.84
16 INT244684 Binding of Mmp14 1 0.23 0.1 0 99.84
17 INT6580 Negative_regulation of Ptgs1 929 0.59 381.53 376.26 99.54
18 INT77955 Negative_regulation of PCS 55 0.43 39.32 5.76 99.44
19 INT145937 Regulation of PCS 32 0.39 19.25 1.97 99.44
20 INT217606 Regulation of Dep1 3 0.25 1.33 0.45 99.44
21 INT290631 Positive_regulation of Ccl24 1 0.01 1.61 0.2 99.36
22 INT101166 Negative_regulation of Binding of Cpox 4 0.15 2.66 1.79 99.20
23 INT215301 Binding of PQBP1 9 0.27 10.36 0.59 99.12
24 INT197250 Localization of Muc5ac 7 0.71 4.83 0.55 99.12
25 INT206821 Positive_regulation of Muc2 6 0.47 2.85 0.44 99.12
26 INT206816 Regulation of Muc2 4 0.58 1.06 0.14 99.12
27 INT8786 Negative_regulation of ALDH7A1 27 0.52 12.81 4.76 99.08
28 INT55335 Binding of Cpox 49 0.34 15.48 18.46 99.04
29 INT34869 Negative_regulation of PTGS2 778 0.59 366.76 319.85 99.00
30 INT22239 Negative_regulation of TAC1 52 0.57 12.96 31.41 98.98
31 INT336555 Binding of AD14 1 0.16 1.03 0 98.96
32 INT158426 Binding of NOTCH1 10 0.36 7.95 0.45 98.88
33 INT712 Positive_regulation of LDHA 160 0.70 175.25 19.11 98.88
34 INT147792 Gene_expression of COPD 230 0.70 287.13 24.1 98.80
35 INT100399 Gene_expression of CCL17 22 0.77 9.38 2.43 98.80
36 INT613 Gene_expression of Alb 268 0.78 149.84 42.78 98.78
37 INT8548 Gene_expression of HP 86 0.77 47.62 11.94 98.78
38 INT217608 Binding of Dep1 2 0.20 0.93 0.19 98.68
39 INT2604 Positive_regulation of Got1 223 0.70 154.78 49.51 98.56
40 INT345961 Negative_regulation of D0Ffm3 1 0.03 3.73 0.07 98.32
41 INT191542 Binding of ABCA3 1 0.22 1.61 0.03 98.28
42 INT250817 Binding of AP5M1 2 0.01 2.72 0.15 98.24
43 INT22030 Negative_regulation of Cysltr1 31 0.39 21.83 12.49 98.22
44 INT21503 Binding of Ptgs1 45 0.48 15.6 22.29 98.22
45 INT3988 Positive_regulation of Gene_expression of IGHE 98 0.68 91.46 9.61 98.20
46 INT74563 Positive_regulation of Gene_expression of ROS1 258 0.61 168.18 34.08 98.12
47 INT119892 Gene_expression of Cftr 54 0.77 23.76 9.73 98.12
48 INT50058 Negative_regulation of Cpox 907 0.58 426.28 428.29 98.10
49 INT216985 Gene_expression of Ccl17 10 0.64 8.74 3.56 98.04
50 INT228729 Negative_regulation of Gene_expression of Ccl17 2 0.48 1.55 0.93 98.04
51 INT336553 Gene_expression of AD14 1 0.26 2.12 0.07 98.00
52 INT1827 Gene_expression of Aap 11 0.67 9.37 12.66 98.00
53 INT336549 Localization of AD14 1 0.27 0.34 0 98.00
54 INT22875 Regulation of CRS 16 0.39 14.33 2.69 97.88
55 INT55114 Gene_expression of CRS 42 0.58 26.86 4.69 97.88
56 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83 97.72
57 INT73047 Positive_regulation of MMP9 133 0.68 73.22 26.42 97.72
58 INT10019 Binding of CD8A 57 0.36 31.49 10.08 97.68
59 INT33664 Negative_regulation of LTA4H 4 0.59 2.34 0.95 97.36
60 INT36751 Gene_expression of ZMYND10 7 0.75 3.92 0.32 97.28
61 INT338134 Positive_regulation of Gene_expression of ZMYND10 1 0.49 0.58 0 97.28
62 INT65260 Positive_regulation of Col7a1 95 0.69 61.73 18.42 97.20
63 INT125312 Positive_regulation of COPD 134 0.59 162.55 20.27 97.18
64 INT290634 Gene_expression of Ccl24 2 0.01 2.34 0.55 97.00
65 INT94467 Positive_regulation of Hand1 71 0.58 59 16.96 96.96
66 INT51980 Protein_catabolism of Mme 6 0.89 2.49 2.06 96.84
67 INT2971 Regulation of IGHE 42 0.61 28.81 7.87 96.80
68 INT179320 Regulation of LDB3 3 0.37 1.55 0.14 96.68
69 INT232567 Binding of Spl 2 0.31 1.88 0.1 96.68
70 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 96.40
71 INT190208 Positive_regulation of MMRN1 15 0.23 14.1 3.37 96.32
72 INT39417 Gene_expression of Fcer2a 65 0.76 32.1 7.37 96.12
73 INT99586 Binding of IRF6 60 0.36 27.87 13.2 96.00
74 INT163080 Gene_expression of STAT6 5 0.59 3.18 2.94 96.00
75 INT149292 Localization of NOTCH1 7 0.54 6.11 1.14 95.96
76 INT151711 Regulation of Adam7 1 0.01 0.85 0.14 95.72
77 INT35366 Binding of AR 87 0.47 30.52 8.9 95.72
78 INT173159 Localization of PPARA 96 0.74 64.55 10.26 95.64
79 INT190204 Positive_regulation of Gene_expression of MMP12 22 0.67 31.31 13.69 95.64
80 INT8837 Positive_regulation of TAC1 59 0.67 21.94 35.97 95.38
81 INT57580 Positive_regulation of TACR1 18 0.69 9.35 12.47 95.38
82 INT20492 Gene_expression of MMP12 89 0.76 81.36 46.12 95.36
83 INT134346 Binding of PCS 51 0.37 22.27 5.67 95.32
84 INT290632 Regulation of Positive_regulation of Cysltr1 1 0.06 1.23 0.49 95.26
85 INT290630 Positive_regulation of Cysltr1 1 0.07 1.22 0.49 95.26
86 INT90370 Gene_expression of Mmp14 3 0.49 3.71 0.93 95.20
87 INT211970 Negative_regulation of Best1 49 0.14 37.33 2.32 95.04
88 INT13556 Gene_expression of CD4 367 0.78 230.82 41.74 95.04
89 INT125099 Gene_expression of AD7 2 0.19 1.64 0.09 94.92
90 INT336546 Gene_expression of Igkv4-78 1 0.21 0.95 0 94.92
91 INT336554 Regulation of AD7 1 0.02 0.39 0 94.92
92 INT336545 Regulation of Igkv4-78 1 0.07 0.39 0 94.92
93 INT1724 Negative_regulation of ACE 437 0.59 315.64 74.48 94.76
94 INT50453 Regulation of Gene_expression of HBG2 6 0.45 1.6 0.86 94.68
95 INT169926 Positive_regulation of Gopc 416 0.46 157.8 58.67 94.28
96 INT28521 Gene_expression of HBG2 56 0.77 16.62 8.64 94.24
97 INT33358 Gene_expression of Cysltr1 46 0.62 24.18 13.36 94.16
98 INT99610 Localization of MMP9 126 0.79 48.46 32.67 94.08
99 INT29503 Gene_expression of Mmp2 95 0.77 56.92 31.68 94.08
100 INT34487 Localization of MMP2 56 0.81 31.41 23.61 94.08
101 INT180743 Binding of SARS 12 0.23 17.94 0.62 94.08
102 INT5539 Negative_regulation of Mme 75 0.59 28.91 41.84 93.84
103 INT44647 Positive_regulation of TBXA2R 14 0.57 6.95 1.64 93.56
104 INT89113 Regulation of Cftr 11 0.62 6.83 4.01 93.32
105 INT14572 Binding of INS 205 0.48 175.43 13.38 93.12
106 INT25463 Negative_regulation of Gene_expression of MRXS5 7 0.38 4.75 2.12 93.12
107 INT336543 Negative_regulation of Adi1 1 0.01 0.55 0.06 93.12
108 INT74682 Positive_regulation of Mmp2 72 0.69 40.46 21.73 93.04
109 INT12992 Negative_regulation of Gene_expression of Ptgs1 33 0.42 20.47 11.77 93.04
110 INT108433 Negative_regulation of Mat1a 16 0.57 14.15 2.82 92.92
111 INT193936 Positive_regulation of PSEN1 5 0.58 11.57 2.95 92.76
112 INT90766 Gene_expression of PCS 93 0.77 40.48 14.51 92.72
113 INT10565 Gene_expression of MRXS5 94 0.53 37.35 19.08 92.64
114 INT150867 Regulation of COPD 54 0.48 71.38 8.8 92.60
115 INT242110 Regulation of IGKV1-22 2 0.06 2.02 0.52 92.48
116 INT8775 Binding of IGHE 167 0.48 102.61 23.54 92.28
117 INT8413 Gene_expression of Ptgs1 248 0.78 110.17 108.58 92.28
118 INT19181 Gene_expression of Bche 35 0.68 16.93 1.52 92.28
119 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 92.16
120 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 92.16
121 INT103094 Binding of PPARA 308 0.47 177.26 34.75 91.92
122 INT161276 Regulation of NHS 7 0.38 1.43 1.4 91.92
123 INT293028 Regulation of Regulation of NHS 1 0.03 0.25 0 91.92
124 INT290629 Negative_regulation of Gene_expression of MAZ 1 0.05 0.97 0.09 91.68
125 INT72060 Positive_regulation of Gene_expression of Ros1 127 0.41 76.76 20.91 91.60
126 INT134841 Regulation of YAP1 2 0.27 3.02 0.09 91.60
127 INT14548 Localization of Tac1 13 0.78 1.43 7.48 91.48
128 INT16966 Positive_regulation of CRS 23 0.60 22.5 3.49 91.36
129 INT206820 Gene_expression of Muc1 17 0.60 13.48 0.36 91.32
130 INT197252 Positive_regulation of Muc1 4 0.50 2.93 0.25 91.32
131 INT55344 Gene_expression of Ros1 396 0.54 217.64 59.98 91.20
132 INT14599 Localization of Tpsab1 36 0.79 14.58 7.18 91.12
133 INT48232 Gene_expression of MMP1 245 0.78 96.31 57.72 90.96
134 INT12360 Regulation of Tac1 31 0.61 5.9 18 90.52
135 INT54054 Binding of App 4 0.48 10.89 2.78 90.28
136 INT9220 Gene_expression of Ighg1 125 0.77 85.74 15.92 90.24
137 INT173504 Positive_regulation of Gene_expression of Ighg1 16 0.47 7.2 2.36 90.24
138 INT108921 Negative_regulation of Positive_regulation of Mapk9 3 0.25 1.8 1.99 89.88
139 INT108922 Negative_regulation of Positive_regulation of Slc50a1 1 0.01 0.73 0.2 89.88
140 INT91764 Positive_regulation of Gene_expression of PLA2G4A 8 0.69 5.43 1.52 89.84
141 INT64864 Gene_expression of PLA2G4A 18 0.77 10.45 4.09 89.84
142 INT91721 Binding of IL18 21 0.48 21.17 6.56 89.80
143 INT133312 Binding of MMP9 25 0.42 16.79 3.83 89.80
144 INT63812 Gene_expression of H1FNT 14 0.06 8.41 1.67 89.68
145 INT22708 Gene_expression of MUC1 297 0.78 232.71 24.19 89.60
146 INT108919 Positive_regulation of Mapk9 9 0.34 3.55 4.74 89.52
147 INT108920 Positive_regulation of Regulation of Slc50a1 1 0.01 0.75 0.21 89.52
148 INT108923 Positive_regulation of Slc50a1 1 0.01 0.73 0.2 89.52
149 INT290628 Gene_expression of MAZ 1 0.07 0.9 0.06 89.20
150 INT23635 Positive_regulation of MMP12 31 0.59 28.19 17.95 89.08
151 INT49804 Negative_regulation of Localization of MUC1 7 0.59 5.84 1.19 89.04
152 INT49803 Negative_regulation of MUC1 37 0.58 26.37 2.06 89.04
153 INT132178 Binding of CD80 41 0.47 15.55 12.98 88.80
154 INT73504 Binding of CD28 35 0.45 15.99 10.04 88.80
155 INT3404 Binding of BCAR1 10 0.33 7.97 1.33 88.72
156 INT336961 Negative_regulation of Asthm1 1 0.00 2.19 0.17 88.64
157 INT141002 Negative_regulation of Fcer2a 15 0.12 7.17 1.88 88.56
158 INT67614 Positive_regulation of PPARA 438 0.68 293.28 63.61 88.44
159 INT297531 Negative_regulation of Ece1 5 0.32 5.49 0.87 88.44
160 INT49802 Localization of MUC1 75 0.81 44.74 8.87 88.40
161 INT70970 Binding of COPD 144 0.42 180.34 18.29 88.24
162 INT176524 Binding of Mapk14 19 0.43 12.54 5.21 88.20
163 INT60436 Negative_regulation of COPD 76 0.37 84.22 9.08 87.76
164 INT36449 Negative_regulation of G6PD 74 0.59 54.15 8.85 87.72
165 INT14165 Negative_regulation of Ahr 14 0.51 8.35 4.17 87.64
166 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 87.56
167 INT138802 Gene_expression of CFTR 36 0.70 18.8 7.02 87.52
168 INT30169 Negative_regulation of Pde4a 107 0.58 81 36.23 87.28
169 INT190833 Regulation of KCNA1 8 0.53 6.61 4.66 86.64
170 INT108918 Regulation of Slc50a1 1 0.01 0.74 0.21 86.56
171 INT239379 Transcription of HBG1 2 0.59 1.76 0.15 86.48
172 INT86024 Gene_expression of PPARA 736 0.78 497.93 91.14 86.08
173 INT2732 Gene_expression of VIP 74 0.78 24.57 33.72 85.84
174 INT87340 Negative_regulation of BCAR1 8 0.38 6.96 2.63 85.80
175 INT34790 Localization of KCNA1 4 0.43 11.34 3.99 85.64
176 INT20121 Negative_regulation of CYBB 34 0.54 15.5 4.44 85.44
177 INT254552 Positive_regulation of Negative_regulation of CYBB 1 0.44 1.45 0.12 85.44
178 INT111559 Gene_expression of Aliq1 11 0.64 11.23 0.96 85.44
179 INT111558 Positive_regulation of Gene_expression of Aliq1 3 0.48 3.45 0.63 85.44
180 INT111560 Negative_regulation of Gene_expression of Aliq1 2 0.41 3.23 0.14 85.44
181 INT240544 Gene_expression of TBX21 12 0.75 5.96 2.97 85.36
182 INT69158 Localization of IL4 48 0.71 31.3 11.98 84.80
183 INT132822 Localization of IL13 26 0.67 22.85 6.66 84.80
184 INT160915 Regulation of Mmp9 16 0.35 10.25 4.07 84.72
185 INT100398 Positive_regulation of Gene_expression of CCL17 6 0.53 2.26 1.19 84.72
186 INT2609 Localization of ELANE 111 0.81 50.22 26.63 84.32
187 INT336552 Positive_regulation of AD14 1 0.19 0.55 0 84.32
188 INT8580 Gene_expression of ELANE 132 0.75 62.98 21.79 84.28
189 INT192406 Regulation of Ighm 16 0.31 5.58 0.29 84.20
190 INT52180 Binding of Aes 38 0.42 23.16 6.7 84.12
191 INT27242 Gene_expression of PGR 153 0.75 98.77 12.79 84.04
192 INT9655 Regulation of Il6 98 0.62 70.92 31.95 83.92
193 INT52196 Negative_regulation of Regulation of Il6 3 0.42 3.42 0.74 83.92
194 INT89290 Regulation of MUC1 19 0.45 10.4 0.81 83.80
195 INT1705 Gene_expression of pCA 126 0.65 88.65 34.81 83.76
196 INT7745 Regulation of Ptafr 7 0.40 1.99 2.12 83.68
197 INT256491 Positive_regulation of Gpm6b 1 0.03 0.5 0 83.68
198 INT217733 Negative_regulation of AMH 4 0.51 1.97 0.38 83.52
199 INT16814 Negative_regulation of COX5A 74 0.57 33.72 28.63 83.44
200 INT16165 Regulation of DMD 114 0.60 35.13 3.64 83.36
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