D:Restless Legs Syndrome

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Disease Term
Synonyms Ekbom S Syndrome, Ekbom Syndrome, Ekboms Syndrome, Familial Acromelalgia, HEREDITARY ACROMELALGIA, Restless Leg Syndrome, Restless Legs, Rls, Syndrome Ekbom, SYNDROME EKBOM S
Documents 484
Hot Single Events 100
Hot Interactions 10

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Restless Legs Syndrome. They are ordered first by their relevance to Restless Legs Syndrome and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT267799 Binding of RLS and ADHD1 1 0.00 4.84 0.14 100.00
2 INT290614 Binding of Th and RLS 1 0.21 3.26 0.31 100.00
3 INT314484 TH Positive_regulation of RLS 1 0.01 1.66 0.29 100.00
4 INT267812 Binding of ATF7IP and RLS 1 0.35 2.01 0.21 100.00
5 INT267644 Binding of Das and RLS 1 0.06 1.04 0.35 100.00
6 INT336480 Binding of Pln and RLS 1 0.02 0.34 0 100.00
7 INT229601 Binding of DIS3 and RLS 1 0.14 2.19 0.06 100.00
8 INT273024 Binding of FXYD1 and RLS 1 0.04 1.24 0.21 100.00
9 INT146997 Binding of PLXNA3 and RLS 1 0.36 0.47 0.1 100.00
10 INT229602 Binding of ETFA and DIS3 1 0.08 1.12 0 98.88
11 INT262377 Binding of Comt and Fmod 1 0.06 1.47 1.29 37.68
12 INT336573 Ptpn2 Regulation of INSR 1 0.00 1.36 0.36 31.92
13 INT97208 Binding of Gabrg1 and Gabbr1 2 0.07 0.31 1.94 5.00
14 INT336556 SLC6A3 Positive_regulation of Gene_expression of GOPC 1 0.08 1.87 1.76 5.00
15 INT336559 SLC6A3 Positive_regulation of GOPC 1 0.08 1 1.15 5.00
16 INT336557 SLC6A3 Positive_regulation of Binding of GOPC 1 0.08 0.5 0.58 5.00
17 INT282202 Tcas1 Negative_regulation of NA 1 0.01 0.32 0.34 5.00
18 INT336561 Binding of DDC and DIO2 1 0.04 0.27 0.24 5.00
19 INT296372 Binding of IDUA and ACD 1 0.03 2.72 0.23 5.00
20 INT274353 DST Regulation of Gopc 1 0.00 0 0.17 5.00
21 INT324347 Binding of UMOD and Scr 1 0.20 2.23 0 5.00
22 INT324342 UMOD Positive_regulation of Scr 1 0.17 1.29 0 5.00
23 INT324312 Binding of GATM and UMOD 1 0.02 1.62 0 5.00
24 INT324306 Binding of GATM and STC1 1 0.02 1.61 0 5.00
25 INT324346 Regulation of UMOD Positive_regulation of Scr 1 0.10 1.31 0 5.00
26 INT324343 SLC12A1 Regulation of Scr 1 0.00 0.25 0 5.00
27 INT324305 Binding of CST3 and UMOD 1 0.05 3.22 0 5.00
28 INT324313 Binding of STC1 and UMOD 1 0.29 3.22 0 5.00
29 INT324311 Binding of UMOD and SHROOM3 1 0.29 1.62 0 5.00
30 INT324310 Binding of STC1 and SHROOM3 1 0.24 1.61 0 5.00
31 INT324344 Positive_regulation of UMOD Regulation of Scr 1 0.24 0.29 0 5.00
32 INT324340 Binding of SLC12A1 and Scr 1 0.00 1.42 0 5.00
33 INT176919 Binding of DLD and Bpifa2 1 0.00 0.08 0 5.00
34 INT324309 Binding of CST3 and GATM 1 0.00 1.6 0 5.00
35 INT324345 Binding of STC1 and Scr 1 0.10 0.22 0 5.00
36 INT324341 UMOD Regulation of Scr 1 0.21 0.29 0 5.00
37 INT176920 DLD Positive_regulation of Binding of Bpifa2 1 0.00 0.08 0 5.00
38 INT324308 Binding of CST3 and SHROOM3 1 0.04 1.6 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Restless Legs Syndrome. They are ordered first by their pain relevance and then by number of times they were reported in Restless Legs Syndrome. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT75742 Binding of RLS 86 0.42 95.27 19.04 100.00
2 INT54924 Gene_expression of RLS 67 0.62 83.2 14.25 100.00
3 INT107129 Positive_regulation of RLS 46 0.60 40.1 8.09 100.00
4 INT142735 Regulation of RLS 33 0.53 45.83 11.35 100.00
5 INT83734 Negative_regulation of RLS 24 0.50 35.75 5.66 100.00
6 INT117893 Binding of Serpind1 15 0.41 24.59 2.41 100.00
7 INT189082 Gene_expression of Serpind1 12 0.65 15.56 1.16 100.00
8 INT125242 Localization of RLS 15 0.64 15.87 4.99 100.00
9 INT211224 Positive_regulation of Serpind1 8 0.59 12.15 1.8 100.00
10 INT211228 Localization of Serpind1 3 0.63 6.11 0.51 100.00
11 INT4782 Positive_regulation of Gene_expression of TH 12 0.47 7.36 2.95 100.00
12 INT267808 Positive_regulation of Gene_expression of RLS 4 0.41 5.96 0.94 100.00
13 INT21877 Negative_regulation of Serpind1 3 0.52 6.85 0.93 100.00
14 INT273025 Phosphorylation of RLS 1 0.67 4.2 0.38 100.00
15 INT286172 Positive_regulation of Protein_catabolism of RLS 1 0.18 7.37 1.02 100.00
16 INT211223 Regulation of Serpind1 3 0.38 2.61 0.21 100.00
17 INT154358 Transcription of RLS 3 0.59 2.99 0.58 100.00
18 INT267800 Regulation of Gene_expression of RLS 2 0.29 3.79 1.07 100.00
19 INT152796 Protein_catabolism of RLS 4 0.59 3.64 0.33 100.00
20 INT211229 Negative_regulation of Gene_expression of Serpind1 1 0.36 3.33 0.89 100.00
21 INT229603 Negative_regulation of Localization of RLS 2 0.36 2.62 0.32 100.00
22 INT311487 Regulation of Regulation of RLS 1 0.26 2.7 1.76 100.00
23 INT7581 Binding of ADHD1 132 0.46 135.1 19.73 100.00
24 INT211226 Regulation of Positive_regulation of Serpind1 1 0.38 1.99 0.2 100.00
25 INT314500 Regulation of Positive_regulation of RLS 1 0.11 1.06 0.41 100.00
26 INT267642 Positive_regulation of Binding of RLS 1 0.33 0.8 0 100.00
27 INT211227 Positive_regulation of Gene_expression of Serpind1 1 0.42 1.34 0.43 100.00
28 INT135020 Positive_regulation of Negative_regulation of RLS 1 0.27 0.87 0.15 100.00
29 INT311488 Positive_regulation of Localization of RLS 1 0.29 0.79 2.38 100.00
30 INT330497 Negative_regulation of Binding of RLS 1 0.24 0.47 0 100.00
31 INT229604 Regulation of Localization of RLS 1 0.38 1.17 0 100.00
32 INT4781 Gene_expression of TH 68 0.73 26.92 24.01 99.98
33 INT154074 Positive_regulation of Gene_expression of Tf 4 0.46 1.64 0.28 99.98
34 INT13716 Positive_regulation of TH 33 0.68 19.11 16 99.92
35 INT122896 Negative_regulation of TH 23 0.57 9.27 6.88 99.84
36 INT326713 Negative_regulation of Thy1 2 0.47 1.08 0.09 99.84
37 INT217 Negative_regulation of Th 134 0.59 26.83 62.63 99.70
38 INT13240 Gene_expression of TF 94 0.76 57.81 10.99 99.62
39 INT11565 Gene_expression of Tf 24 0.68 5.89 4.36 99.58
40 INT86999 Regulation of DYNLL1 5 0.44 2.85 2.18 99.56
41 INT30317 Regulation of TH 14 0.43 7.27 5.38 99.52
42 INT314508 Regulation of Positive_regulation of TH 1 0.04 0.92 0.08 99.52
43 INT273027 Regulation of Negative_regulation of FXYD1 1 0.05 1.19 0.35 99.48
44 INT107401 Regulation of Das 9 0.18 3.02 1.31 99.28
45 INT247999 Negative_regulation of FXYD1 2 0.06 1.75 0.35 99.22
46 INT122952 Positive_regulation of COMT 13 0.50 8.1 8.89 98.84
47 INT76149 Gene_expression of Das 18 0.37 6.55 3.92 98.74
48 INT739 Negative_regulation of POMC 358 0.59 102.28 166.77 98.64
49 INT356020 Binding of MKS1 1 0.02 1.36 0.2 98.60
50 INT76714 Binding of Drd3 9 0.37 2.33 4.09 98.54
51 INT22962 Gene_expression of FXYD1 2 0.58 3.32 1.12 98.48
52 INT267806 Negative_regulation of Pln 8 0.40 4.01 1.63 98.34
53 INT36499 Negative_regulation of Tf 6 0.38 3.02 1.85 98.14
54 INT282635 Positive_regulation of Binding of ADHD1 4 0.40 3.62 0.24 98.12
55 INT1579 Gene_expression of PRL 279 0.78 119.2 55.41 98.08
56 INT273026 Localization of FXYD1 1 0.08 1.53 0 98.00
57 INT135629 Binding of COMT 33 0.48 16.68 19.37 97.80
58 INT66987 Regulation of Th 23 0.61 7.86 6.8 97.72
59 INT27627 Binding of Rac1 41 0.41 22.88 13.68 97.40
60 INT101925 Binding of Drd1a 9 0.43 1.82 4.97 97.38
61 INT296914 Regulation of Pln 2 0.19 3.08 1.23 97.36
62 INT89368 Positive_regulation of Tf 7 0.34 3.62 0.83 97.12
63 INT170054 Negative_regulation of Gopc 280 0.38 117.89 42.4 97.08
64 INT262375 Binding of Fmod 1 0.20 12.37 10.1 97.08
65 INT184825 Regulation of Thy1 7 0.42 4.14 0.28 96.68
66 INT738 Regulation of POMC 459 0.62 111.19 243.74 96.28
67 INT7327 Regulation of Th 164 0.62 29.67 110.14 96.28
68 INT1430 Regulation of PDYN 88 0.60 16.99 60.32 96.28
69 INT314510 Protein_catabolism of TH 1 0.10 3.28 1.86 96.24
70 INT314499 Negative_regulation of Protein_catabolism of TH 1 0.04 1.06 0.54 96.24
71 INT60764 Positive_regulation of PPIG 39 0.67 17.08 13.48 96.16
72 INT267805 Binding of Pln 3 0.33 0.8 0.4 95.56
73 INT232667 Binding of Pd 17 0.16 20.76 3.58 95.40
74 INT103878 Binding of PTGDR 9 0.48 6.22 7.23 95.12
75 INT60436 Negative_regulation of COPD 76 0.37 84.22 9.08 94.64
76 INT3505 Binding of TH 5 0.39 2.6 1.8 94.16
77 INT94028 Regulation of Twist1 37 0.44 22.41 5.33 94.00
78 INT119412 Gene_expression of Snca 15 0.66 11.27 3.39 93.68
79 INT3952 Negative_regulation of ALB 116 0.59 72.18 18.35 92.76
80 INT5660 Binding of Oprd1 477 0.48 71.86 342.06 91.84
81 INT314511 Positive_regulation of Binding of TH 1 0.04 0.68 0.38 91.32
82 INT78567 Positive_regulation of Gene_expression of Th 25 0.68 5.32 10.75 91.12
83 INT104284 Positive_regulation of Notch3 7 0.50 5.57 0.99 91.04
84 INT60600 Binding of PSS 5 0.32 3.59 1.42 90.64
85 INT103271 Regulation of Sit1 3 0.24 1.32 0.47 90.16
86 INT30817 Gene_expression of Th 142 0.76 33.56 38.12 90.16
87 INT296385 Binding of IDUA 12 0.39 20.73 0.93 89.96
88 INT314505 Positive_regulation of Protein_catabolism of TH 1 0.05 1.07 0.56 89.68
89 INT267804 Gene_expression of Pln 4 0.47 1.45 0.51 88.64
90 INT229605 Binding of DIS3 1 0.11 1.88 0 88.16
91 INT2212 Binding of Abat 89 0.48 18.36 63.99 87.04
92 INT1361 Negative_regulation of Gnrhr 118 0.58 57.77 35.54 86.96
93 INT246573 Binding of PGRMC1 1 0.03 0.39 0 86.32
94 INT28325 Negative_regulation of Tst 13 0.51 12.41 3.16 85.60
95 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 84.84
96 INT356021 Gene_expression of MKS1 1 0.04 3.38 0 83.44
97 INT104031 Regulation of ENPEP 18 0.33 13.48 1.69 82.32
98 INT167867 Gene_expression of RLS6 1 0.40 0.16 0 82.16
99 INT16404 Regulation of CD4 54 0.61 33.05 10.29 80.84
100 INT86998 Regulation of HIVEP1 49 0.44 37.83 4 80.84
101 INT188449 Gene_expression of ENPEP 12 0.55 11.29 3.96 79.36
102 INT31780 Binding of DIO2 17 0.36 10.07 10 73.32
103 INT147412 Binding of DRD4 11 0.47 7.57 2.77 73.32
104 INT37951 Positive_regulation of PDSS1 8 0.41 2.5 0.27 73.20
105 INT306780 Binding of FXYD1 1 0.36 0.31 0 72.04
106 INT110638 Negative_regulation of COMT 43 0.59 21.03 21.05 71.04
107 INT59125 Positive_regulation of Dps1 1 0.37 0.57 0.11 70.76
108 INT519 Negative_regulation of Comt 52 0.59 17.65 20.39 69.40
109 INT67855 Negative_regulation of PPIG 64 0.57 17.83 13.54 68.36
110 INT203 Positive_regulation of Pomc 257 0.70 90.56 92.84 67.68
111 INT336478 Positive_regulation of Pln 1 0.35 0.13 0 67.36
112 INT720 Positive_regulation of POMC 807 0.70 237.37 353.83 67.20
113 INT41892 Gene_expression of HBM 48 0.64 28.32 5.64 66.44
114 INT117585 Regulation of Hcrt 10 0.56 6.16 1.77 66.32
115 INT15742 Negative_regulation of EPO 37 0.59 17.44 1.84 65.72
116 INT237093 Binding of crf 5 0.38 16.18 0.38 65.68
117 INT237653 Gene_expression of Sfn 6 0.59 5.54 2.26 65.36
118 INT18340 Gene_expression of CRX 16 0.22 13.85 7.13 65.28
119 INT97984 Negative_regulation of SLC6A4 45 0.59 15.43 18.09 64.32
120 INT5380 Positive_regulation of Gene_expression of Fos 243 0.70 105.65 131.05 63.72
121 INT5379 Gene_expression of Fos 656 0.78 255.5 292.54 63.36
122 INT132453 Binding of TF 31 0.36 12.98 1.22 60.12
123 INT7207 Regulation of HBG1 27 0.60 22.1 1.12 59.48
124 INT203184 Transcription of C7orf49 1 0.05 1.7 1.4 58.36
125 INT17825 Gene_expression of Flvcr2 44 0.68 12.58 28.08 58.08
126 INT306772 Positive_regulation of Negative_regulation of Cyp1a2 1 0.08 0.06 0.04 56.88
127 INT47742 Binding of Flvcr2 26 0.42 3.28 15.87 56.16
128 INT47860 Negative_regulation of Cyp1a2 20 0.57 6.06 10 55.84
129 INT250622 Binding of MCTS1 4 0.40 0.91 1.15 55.20
130 INT113987 Localization of IK 29 0.23 16.73 8.25 55.12
131 INT250599 Gene_expression of MCTS1 29 0.64 1.4 1.89 53.92
132 INT9188 Localization of HBG1 12 0.75 8.14 2.24 53.76
133 INT73431 Positive_regulation of Nos3 82 0.65 53.22 11.61 53.04
134 INT85963 Gene_expression of LIFR 23 0.75 9 0.98 52.08
135 INT81206 Binding of ENPEP 11 0.47 5.19 0.88 50.64
136 INT43901 Negative_regulation of Ptpn2 65 0.37 56.32 7.48 47.36
137 INT185181 Phosphorylation of Pth 2 0.64 1.51 0.3 46.64
138 INT425 Localization of PRL 455 0.81 189.64 144.8 45.92
139 INT1578 Negative_regulation of Localization of PRL 52 0.59 20.62 17.18 45.92
140 INT71634 Gene_expression of SLC6A3 45 0.78 13.48 15.23 45.20
141 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 42.44
142 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 42.44
143 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 42.44
144 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 42.44
145 INT60526 Gene_expression of IL10 449 0.78 292.71 107.84 42.44
146 INT92732 Gene_expression of Tcas1 2 0.05 0.34 1.83 33.60
147 INT184853 Gene_expression of ADHD1 87 0.65 89.2 11.8 33.52
148 INT279349 Localization of IDUA 7 0.76 4.97 0.07 33.52
149 INT353445 Positive_regulation of PSG5 1 0.26 0.65 0.14 30.56
150 INT178455 Localization of LIFR 6 0.61 2.24 0.83 29.68
151 INT294699 Negative_regulation of Localization of LIFR 2 0.04 1.52 0.67 29.68
152 INT154104 Binding of ARID1B 47 0.39 69.82 1.49 25.00
153 INT154102 Negative_regulation of ARID1B 5 0.35 6.45 0.1 25.00
154 INT154103 Positive_regulation of Negative_regulation of ARID1B 1 0.42 1.03 0 25.00
155 INT234493 Gene_expression of sch 5 0.67 3.87 1.22 23.28
156 INT246572 Positive_regulation of Negative_regulation of PGRMC1 1 0.06 0.28 0 21.00
157 INT246575 Negative_regulation of PGRMC1 1 0.05 0.28 0 21.00
158 INT57368 Regulation of ADHD1 39 0.50 42.23 5.01 20.84
159 INT176904 Negative_regulation of Transcription of PDSS1 1 0.02 0.37 0 17.28
160 INT176897 Transcription of PDSS1 1 0.03 0.36 0 17.28
161 INT1020 Negative_regulation of BCHE 109 0.59 44.86 16.4 16.32
162 INT249049 Positive_regulation of ARID1B 14 0.56 24.77 0.71 13.68
163 INT189755 Gene_expression of CCND3 42 0.65 10.88 0.39 9.84
164 INT155 Positive_regulation of Prl 1233 0.70 317.93 457.82 5.00
165 INT18357 Gene_expression of TRPV1 825 0.78 307.11 382.81 5.00
166 INT626 Localization of CALCA 289 0.81 125.39 221.15 5.00
167 INT6665 Gene_expression of FOS 520 0.77 165.31 217.66 5.00
168 INT156 Negative_regulation of Prl 542 0.59 131.97 192.24 5.00
169 INT528 Gene_expression of Prl 693 0.78 217.18 192.2 5.00
170 INT867 Gene_expression of IFNA1 930 0.78 594.85 168.03 5.00
171 INT14843 Gene_expression of Gabrg1 301 0.77 62.63 139.16 5.00
172 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 5.00
173 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
174 INT1498 Gene_expression of Gh 521 0.75 220.84 81.16 5.00
175 INT57380 Phosphorylation of Creb1 213 0.82 66.8 71.26 5.00
176 INT13276 Regulation of Ltp 107 0.53 30.78 69.13 5.00
177 INT546 Binding of ALB 311 0.48 85.98 60.14 5.00
178 INT102020 Gene_expression of Creb1 190 0.78 57.31 59.77 5.00
179 INT52264 Gene_expression of IK 180 0.77 90.87 51.87 5.00
180 INT8490 Negative_regulation of CALCA 87 0.59 29.73 51.34 5.00
181 INT11406 Positive_regulation of Localization of CALCA 49 0.70 20.64 42.8 5.00
182 INT3987 Positive_regulation of IGHE 316 0.70 283.2 40.16 5.00
183 INT5973 Regulation of IL1B 109 0.62 66.6 39.88 5.00
184 INT8837 Positive_regulation of TAC1 59 0.67 21.94 35.97 5.00
185 INT3679 Gene_expression of AVP 171 0.78 72.9 35.23 5.00
186 INT6302 Binding of IFNA1 196 0.48 133.85 32.73 5.00
187 INT90792 Localization of Il10 144 0.80 87.88 30.03 5.00
188 INT169180 Binding of SNRNP70 204 0.47 119.1 29.3 5.00
189 INT15610 Localization of GOPC 223 0.65 68.26 28.7 5.00
190 INT6624 Gene_expression of Pth 135 0.76 110.27 27.54 5.00
191 INT11159 Gene_expression of EGFR 698 0.78 548.93 25.69 5.00
192 INT20003 Gene_expression of Scn2a1 125 0.71 8.78 23.94 5.00
193 INT682 Negative_regulation of AVP 97 0.59 50.67 23.91 5.00
194 INT76123 Gene_expression of Lep 193 0.78 94.17 22.76 5.00
195 INT105021 Binding of GOPC 187 0.40 60.39 20.38 5.00
196 INT712 Positive_regulation of LDHA 160 0.70 175.25 19.11 5.00
197 INT4420 Positive_regulation of GOT1 103 0.64 88.4 18.38 5.00
198 INT871 Negative_regulation of Gene_expression of Prl 53 0.58 18.89 17.79 5.00
199 INT505 Positive_regulation of GPT 89 0.67 69.38 14.94 5.00
200 INT109031 Positive_regulation of Eif2ak3 44 0.69 21.11 14.72 5.00
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