D:Reticuloendotheliosis

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Disease Term
Synonyms Reticuloendothelioses
Documents 6
Hot Single Events 12
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Reticuloendotheliosis. They are ordered first by their relevance to Reticuloendotheliosis and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT243374 SERPINH1 Positive_regulation of Gene_expression of CAMK4 1 0.07 1.01 0 61.28
2 INT299155 Smcp Negative_regulation of Spp1 1 0.00 0.7 0.22 5.00
3 INT299156 Smcp Negative_regulation of Tnc 1 0.05 0.7 0.22 5.00
4 INT299154 Smcp Negative_regulation of Lgals3 1 0.04 0.69 0.22 5.00
5 INT317895 Fos Regulation of Transcription of Egr1 1 0.41 1.03 0.17 5.00
6 INT317897 Egr1 Regulation of Transcription of Fosb 1 0.34 1.08 0.17 5.00
7 INT317889 Fos Regulation of Transcription of Fosb 1 0.30 1.08 0.17 5.00
8 INT317892 Egr1 Regulation of Transcription of Fos 1 0.41 1.03 0.17 5.00
9 INT317891 Binding of Akt1 and Mtf1 1 0.21 1.04 0.11 5.00
10 INT317893 Binding of Eef1a1 and Mmp9 1 0.02 1.04 0.11 5.00
11 INT317888 Binding of Eef1a1 and Pik3r1 1 0.01 1.04 0.11 5.00
12 INT317896 Binding of Mmp9 and Mtf1 1 0.36 1.04 0.11 5.00
13 INT317887 Binding of Mtf1 and Pik3r1 1 0.25 1.04 0.11 5.00
14 INT299158 Binding of Lgals3 and Renbp 1 0.00 0.64 0.11 5.00
15 INT317898 Binding of Akt1 and Eef1a1 1 0.01 1.04 0.11 5.00
16 INT268679 Binding of HDAC1 and NCOR2 3 0.17 2.8 0.07 5.00
17 INT284916 IL1RN Negative_regulation of HDAC4 1 0.00 1.66 0.03 5.00
18 INT284919 XRCC6 Negative_regulation of BAX 1 0.01 0.64 0 5.00
19 INT284920 Binding of HDAC1 and NCOR1 1 0.03 0.13 0 5.00
20 INT243373 Binding of CASP8 and SERPINH1 1 0.28 1.49 0 5.00
21 INT284918 RUNX1T1 Regulation of DNMT1 1 0.21 1.09 0 5.00
22 INT284917 RUNX1T1 Regulation of HDAC9 1 0.19 1.09 0 5.00
23 INT284914 Binding of HDAC1 and NCK1 1 0.00 0.13 0 5.00
24 INT299157 Binding of Lgals3 and Fn1 1 0.04 0.16 0 5.00
25 INT284915 Binding of CDKN2B and HIST2H3C 1 0.05 0.43 0 5.00
26 INT284995 Binding of HDAC1 and Sin3a 1 0.00 0.13 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Reticuloendotheliosis. They are ordered first by their pain relevance and then by number of times they were reported in Reticuloendotheliosis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT9553 Gene_expression of AK1 4 0.75 3.08 0.26 92.68
2 INT162533 Regulation of Lgals3 9 0.45 6.61 1.73 91.24
3 INT243372 Positive_regulation of Arhgdia 1 0.45 0.32 0 90.08
4 INT243400 Positive_regulation of ZFP36L2 1 0.43 0.27 0 89.36
5 INT172483 Positive_regulation of TFAP4 2 0.44 0.33 0 88.64
6 INT109920 Positive_regulation of PTK2B 5 0.43 2.21 0.43 88.08
7 INT243398 Positive_regulation of ARPC4 1 0.42 0.27 0 87.52
8 INT243384 Positive_regulation of RASD1 1 0.18 0.26 0 86.96
9 INT243401 Positive_regulation of SNN 1 0.17 0.26 0 86.40
10 INT252209 Positive_regulation of Gene_expression of Lgals3 10 0.57 8.29 1.62 85.04
11 INT137614 Gene_expression of Lgals3 70 0.77 66.13 12.53 84.04
12 INT233650 Positive_regulation of Zbtb16 4 0.64 2.56 1.29 80.24
13 INT86560 Localization of Lgals3 5 0.75 7.21 2.23 75.36
14 INT46121 Negative_regulation of SERPINH1 14 0.38 10.84 4.41 68.76
15 INT137613 Regulation of Gene_expression of Lgals3 4 0.61 2.18 0.32 58.24
16 INT230002 Gene_expression of CAMK4 3 0.09 2.59 0.22 58.12
17 INT89519 Negative_regulation of COL1A2 10 0.36 6.26 2.17 55.40
18 INT123885 Positive_regulation of Lgals3 23 0.57 24.38 6.32 53.88
19 INT27551 Gene_expression of SERPINH1 45 0.62 42.87 9.04 49.76
20 INT224608 Positive_regulation of Gene_expression of SERPINH1 4 0.55 3.34 0.58 49.76
21 INT188172 Gene_expression of COL4A1 5 0.39 2.34 0 38.84
22 INT25251 Binding of Fos 19 0.36 7.96 3.73 38.40
23 INT152861 Binding of S100a9 11 0.37 12.19 2.91 38.20
24 INT237619 Gene_expression of Mag 34 0.63 31 5.07 38.00
25 INT205196 Gene_expression of Lpar2 18 0.74 12.19 3.49 34.32
26 INT317879 Positive_regulation of Gene_expression of Nr1d1 1 0.47 1.09 0.14 25.32
27 INT149821 Gene_expression of Nr1d1 5 0.63 4.46 1.17 24.92
28 INT51028 Regulation of Il1b 28 0.60 21.15 12.47 23.04
29 INT317878 Localization of Nr1d1 1 0.71 1.12 0.15 19.04
30 INT243390 Gene_expression of HIC1 1 0.62 2.72 0.06 8.64
31 INT15543 Gene_expression of CASP8 32 0.75 25.6 2.61 8.28
32 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
33 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 5.00
34 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 5.00
35 INT7533 Gene_expression of Tlr4 720 0.78 343.22 121.57 5.00
36 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83 5.00
37 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
38 INT170332 Gene_expression of IFN1@ 477 0.75 275.21 69.65 5.00
39 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64 5.00
40 INT9657 Positive_regulation of Gene_expression of Il6 237 0.70 180.45 63.6 5.00
41 INT1951 Positive_regulation of Tlr4 345 0.70 176.99 62.42 5.00
42 INT115384 Positive_regulation of Mmp9 121 0.68 94.74 43.02 5.00
43 INT390 Positive_regulation of Agt 170 0.70 61.47 36.08 5.00
44 INT60710 Gene_expression of Col7a1 217 0.78 113.2 35.2 5.00
45 INT1179 Negative_regulation of Ace 157 0.59 67.03 30.46 5.00
46 INT34729 Positive_regulation of IFN1@ 233 0.67 128.04 30.38 5.00
47 INT59449 Negative_regulation of Timp1 76 0.42 54.86 26.99 5.00
48 INT57874 Gene_expression of Egr1 113 0.78 68.46 24.95 5.00
49 INT151758 Gene_expression of PYCARD 91 0.63 14.54 24.27 5.00
50 INT110427 Gene_expression of Spp1 199 0.78 176.11 23.31 5.00
51 INT71875 Localization of Nfkb1 92 0.78 48.13 22.94 5.00
52 INT138696 Positive_regulation of Ccl2 57 0.67 59.57 19.58 5.00
53 INT192409 Positive_regulation of Gene_expression of IFN1@ 102 0.67 64.66 18.8 5.00
54 INT4420 Positive_regulation of GOT1 103 0.64 88.4 18.38 5.00
55 INT28215 Gene_expression of CDKN1A 196 0.76 113.9 18.3 5.00
56 INT133647 Negative_regulation of HDAC9 149 0.57 106.84 17.9 5.00
57 INT116978 Gene_expression of CCR6 53 0.78 56 17.73 5.00
58 INT6480 Positive_regulation of IL1RN 59 0.69 33.7 16.66 5.00
59 INT170754 Localization of IFN1@ 121 0.78 66.78 15.6 5.00
60 INT43906 Regulation of Tlr4 71 0.53 35.18 15.49 5.00
61 INT87823 Positive_regulation of Cxcl2 51 0.66 35.47 14.79 5.00
62 INT75502 Positive_regulation of CDKN1A 123 0.68 70.75 14.74 5.00
63 INT27242 Gene_expression of PGR 153 0.75 98.77 12.79 5.00
64 INT70816 Negative_regulation of Fos 32 0.58 13 11.18 5.00
65 INT75137 Regulation of Akt1 74 0.48 37.89 9.7 5.00
66 INT57162 Positive_regulation of Gene_expression of CDKN1A 64 0.68 35.3 9.69 5.00
67 INT140224 Localization of Ccl2 32 0.72 26.91 9.39 5.00
68 INT64815 Binding of Jun 49 0.48 21.47 8.59 5.00
69 INT1952 Negative_regulation of Positive_regulation of Tlr4 33 0.51 15.8 7.41 5.00
70 INT1950 Positive_regulation of Positive_regulation of Tlr4 38 0.49 20.17 7.14 5.00
71 INT23246 Gene_expression of HLA-DRB4 37 0.64 36.79 6.61 5.00
72 INT44163 Gene_expression of Ren1 69 0.78 97.75 6.27 5.00
73 INT125066 Negative_regulation of HDAC4 56 0.49 41.55 5.42 5.00
74 INT116229 Gene_expression of C1qa 28 0.77 18.53 5.35 5.00
75 INT176524 Binding of Mapk14 19 0.43 12.54 5.21 5.00
76 INT111100 Gene_expression of Dusp1 18 0.76 14.81 5.21 5.00
77 INT116744 Binding of Pik3r1 22 0.36 12.77 5.01 5.00
78 INT161220 Binding of Ccl2 17 0.46 17.63 4.94 5.00
79 INT47766 Transcription of Fos 25 0.69 8.78 4.42 5.00
80 INT170455 Gene_expression of Atp8a1 66 0.75 24.63 3.94 5.00
81 INT103350 Gene_expression of DNMT1 15 0.67 9.77 3.83 5.00
82 INT187819 Regulation of IFN1@ 25 0.60 12.89 3.55 5.00
83 INT193281 Binding of CAP1 7 0.07 4.57 3.53 5.00
84 INT12923 Negative_regulation of Atp9a 17 0.35 7.87 3.52 5.00
85 INT124579 Localization of BAX 35 0.78 30.31 3.43 5.00
86 INT136791 Negative_regulation of Spp1 24 0.59 23.6 3.33 5.00
87 INT56601 Positive_regulation of Ccl4 9 0.47 6.27 3.28 5.00
88 INT172551 Negative_regulation of INCENP 38 0.07 20.83 3.14 5.00
89 INT75499 Positive_regulation of Positive_regulation of CDKN1A 12 0.60 7.28 2.84 5.00
90 INT143684 Negative_regulation of Fosb 4 0.43 2.37 2.72 5.00
91 INT190280 Gene_expression of DICER1 12 0.65 9.54 2.67 5.00
92 INT221097 Negative_regulation of Atp8a1 15 0.57 10.52 2.65 5.00
93 INT169987 Transcription of GOPC 45 0.60 21.88 2.61 5.00
94 INT36923 Binding of Mdk 7 0.35 3.81 2.58 5.00
95 INT96640 Negative_regulation of Gene_expression of Egr1 13 0.43 7.22 2.48 5.00
96 INT104733 Positive_regulation of Gene_expression of Ren1 24 0.67 43.87 2.47 5.00
97 INT137135 Gene_expression of THBS1 28 0.75 11.55 2.45 5.00
98 INT223080 Binding of Pdgfa 8 0.18 7.21 2.44 5.00
99 INT74262 Negative_regulation of Egr1 15 0.57 7.51 2.41 5.00
100 INT163063 Positive_regulation of C1qa 10 0.67 6.06 2.29 5.00
101 INT163064 Positive_regulation of Gene_expression of C1qa 9 0.67 6.51 2.29 5.00
102 INT35380 Binding of Fn1 8 0.35 4.84 2.23 5.00
103 INT12622 Localization of LGALS1 9 0.78 0.55 2.19 5.00
104 INT151036 Positive_regulation of Lcn2 13 0.49 8.57 2 5.00
105 INT317880 Regulation of Gene_expression of Dusp1 2 0.42 2.98 1.94 5.00
106 INT85084 Gene_expression of KRT19 66 0.73 42.56 1.82 5.00
107 INT241412 Positive_regulation of Mag 25 0.37 8.59 1.8 5.00
108 INT317882 Regulation of Gene_expression of Mag 7 0.37 5.17 1.61 5.00
109 INT82866 Localization of Atp9a 13 0.78 6.95 1.56 5.00
110 INT207092 Localization of Dusp1 6 0.70 4.7 1.51 5.00
111 INT121970 Negative_regulation of Transcription of Fos 4 0.42 2.52 1.48 5.00
112 INT152308 Binding of Lgals3 13 0.40 6.39 1.44 5.00
113 INT141344 Transcription of Egr1 11 0.70 5.59 1.34 5.00
114 INT211198 Localization of SERPINH1 2 0.66 4.33 1.25 5.00
115 INT228772 Positive_regulation of Localization of Ccl2 3 0.48 4.23 1.21 5.00
116 INT260447 Binding of HDAC1 8 0.23 4.47 1.12 5.00
117 INT242519 Localization of Ntrk3 3 0.52 3.32 1.08 5.00
118 INT259601 Positive_regulation of Mmp12 8 0.48 5.67 1.03 5.00
119 INT299153 Negative_regulation of Tnc 2 0.42 8.14 0.98 5.00
120 INT192564 Binding of HAT1 5 0.15 2.77 0.96 5.00
121 INT103882 Gene_expression of MECP2 17 0.76 10.47 0.96 5.00
122 INT120164 Gene_expression of OPCML 47 0.77 36.89 0.94 5.00
123 INT109397 Binding of Mag 6 0.08 4.38 0.91 5.00
124 INT252212 Negative_regulation of Gene_expression of Lgals3 5 0.43 4.82 0.88 5.00
125 INT287738 Positive_regulation of Gene_expression of Lpar2 4 0.48 3.51 0.82 5.00
126 INT146521 Negative_regulation of Positive_regulation of CDKN1A 6 0.42 3.29 0.79 5.00
127 INT74019 Regulation of TSC1 27 0.35 23.61 0.79 5.00
128 INT201859 Positive_regulation of Gene_expression of DNMT1 4 0.60 6.43 0.75 5.00
129 INT284955 Localization of HDAC1 2 0.47 1.71 0.74 5.00
130 INT230001 Binding of DEFA1 3 0.06 3.53 0.68 5.00
131 INT166024 Protein_catabolism of AKT1 5 0.46 2.6 0.64 5.00
132 INT317874 Positive_regulation of Angptl4 4 0.69 6.72 0.63 5.00
133 INT111609 Gene_expression of CTNNA1 3 0.46 3.2 0.57 5.00
134 INT139321 Positive_regulation of Saa2 5 0.48 6.64 0.54 5.00
135 INT179362 Gene_expression of Smcp 5 0.54 4.5 0.52 5.00
136 INT177842 Negative_regulation of HDAC1 6 0.31 4.65 0.49 5.00
137 INT231565 Positive_regulation of YWHAE 4 0.23 3.07 0.49 5.00
138 INT252211 Negative_regulation of Lgals3 6 0.43 4.82 0.48 5.00
139 INT61884 Positive_regulation of HIST2H4A 3 0.10 2.87 0.48 5.00
140 INT141342 Negative_regulation of Transcription of Egr1 4 0.43 2.39 0.45 5.00
141 INT317883 Localization of Csf3r 1 0.70 3.56 0.43 5.00
142 INT146400 Positive_regulation of DNMT1 4 0.45 0.91 0.43 5.00
143 INT317886 Positive_regulation of Gene_expression of Mag 5 0.09 4.41 0.41 5.00
144 INT317875 Binding of Pdgfb 3 0.10 1.15 0.36 5.00
145 INT163489 Binding of CDH1 13 0.19 8.63 0.35 5.00
146 INT82797 Transcription of CDKN1A 11 0.69 8.01 0.32 5.00
147 INT185886 Gene_expression of JUP 20 0.75 15.41 0.32 5.00
148 INT178400 Negative_regulation of Gene_expression of Dusp1 4 0.40 3.61 0.31 5.00
149 INT142069 Positive_regulation of Lrg1 3 0.44 2.9 0.3 5.00
150 INT166403 Gene_expression of SPINT2 4 0.62 2.74 0.29 5.00
151 INT278723 Binding of HIST2H3C 2 0.04 1.74 0.28 5.00
152 INT237735 Negative_regulation of Lgals3 2 0.30 1.39 0.27 5.00
153 INT132519 Regulation of OPCML 4 0.54 5.18 0.25 5.00
154 INT284938 Regulation of DNMT1 2 0.22 1.17 0.24 5.00
155 INT154398 Transcription of Fosb 4 0.58 1.16 0.21 5.00
156 INT317881 Transcription of Eef1a1 2 0.03 1.38 0.18 5.00
157 INT317877 Negative_regulation of Transcription of Fosb 1 0.30 1.1 0.17 5.00
158 INT284968 Positive_regulation of CDA 2 0.05 0.34 0.15 5.00
159 INT59955 Gene_expression of RASSF1 3 0.60 3.43 0.13 5.00
160 INT205083 Positive_regulation of JUP 6 0.49 5.51 0.13 5.00
161 INT241420 Phosphorylation of Mag 2 0.29 0.91 0.13 5.00
162 INT317899 Positive_regulation of RGCC 1 0.20 1.5 0.12 5.00
163 INT284981 Protein_catabolism of RAF1 2 0.08 1.62 0.12 5.00
164 INT243382 Positive_regulation of CSTA 4 0.05 14.65 0.12 5.00
165 INT258077 Negative_regulation of Gene_expression of DNMT1 2 0.30 1.27 0.12 5.00
166 INT284989 Localization of INTS2 2 0.43 1.64 0.11 5.00
167 INT317884 Transcription of Mtf1 1 0.63 1.02 0.11 5.00
168 INT258063 Negative_regulation of DNMT1 3 0.28 1.36 0.11 5.00
169 INT197707 Gene_expression of SLC39A8 1 0.22 0.28 0.1 5.00
170 INT284953 Protein_catabolism of CDA 1 0.07 1.18 0.1 5.00
171 INT242173 Positive_regulation of Gene_expression of JUP 2 0.49 2.37 0.09 5.00
172 INT284980 Positive_regulation of Protein_catabolism of HDAC2 1 0.20 0.81 0.08 5.00
173 INT181214 Negative_regulation of HLA-DQA2 4 0.03 1.46 0.08 5.00
174 INT174100 Gene_expression of YWHAE 14 0.31 12.42 0.08 5.00
175 INT284484 Positive_regulation of Gene_expression of YWHAE 3 0.23 3.4 0.08 5.00
176 INT284976 Protein_catabolism of HDAC2 1 0.28 0.8 0.08 5.00
177 INT184989 Positive_regulation of CDKN2B 3 0.47 2.77 0.07 5.00
178 INT317871 Positive_regulation of Localization of Csf3r 1 0.47 0.85 0.07 5.00
179 INT245123 Gene_expression of CDKN2B 6 0.68 3.62 0.07 5.00
180 INT284952 Phosphorylation of HAT1 1 0.05 0 0.05 5.00
181 INT284973 Negative_regulation of Negative_regulation of HDAC1 1 0.20 1.59 0.04 5.00
182 INT284958 Negative_regulation of HDAC6 1 0.25 1.56 0.04 5.00
183 INT284992 Negative_regulation of HDAC8 1 0.21 2.36 0.04 5.00
184 INT284979 Binding of HIST2H4A 2 0.05 2 0.04 5.00
185 INT284961 Protein_catabolism of FLT3 1 0.01 0.58 0.03 5.00
186 INT208568 Gene_expression of LINS 3 0.06 0.38 0.03 5.00
187 INT299152 Positive_regulation of Localization of Lgals3 1 0.41 0.31 0.03 5.00
188 INT317885 Positive_regulation of Ccl6 1 0.47 1.36 0.03 5.00
189 INT284971 Positive_regulation of Protein_catabolism of MTTP 1 0.45 0.54 0.03 5.00
190 INT317876 Positive_regulation of Nr1d1 1 0.47 1.37 0.03 5.00
191 INT284984 Protein_catabolism of MTTP 1 0.64 0.53 0.03 5.00
192 INT284937 Negative_regulation of Positive_regulation of CDKN2B 1 0.37 0.31 0 5.00
193 INT284943 Gene_expression of DNMT3A 2 0.39 1.46 0 5.00
194 INT169503 Gene_expression of MBD1 2 0.57 0.53 0 5.00
195 INT277612 Localization of HDAC9 3 0.45 0.55 0 5.00
196 INT243381 Gene_expression of CST6 4 0.71 4.05 0 5.00
197 INT185001 Gene_expression of CDH13 5 0.46 4.71 0 5.00
198 INT243385 Negative_regulation of SPINT2 1 0.40 2.41 0 5.00
199 INT243396 Positive_regulation of CST6 2 0.46 1.74 0 5.00
200 INT243394 Gene_expression of EMP3 1 0.74 1.71 0 5.00
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