D:Retinal Degeneration

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Disease Term
Synonyms Degeneration Retinal, DEGENERATIONS RETINAL, Retinal Degenerations
Documents 15
Hot Single Events 60
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Retinal Degeneration. They are ordered first by their relevance to Retinal Degeneration and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT242162 Binding of Ccnd1 and Wnt2 1 0.10 0.23 0.34 5.00
2 INT242164 Wnt2 Positive_regulation of Localization of Apc 1 0.13 1.53 0.32 5.00
3 INT242163 Wnt2 Positive_regulation of Regulation of Apc 1 0.13 0.71 0.13 5.00
4 INT242167 Binding of Dkk1 and Kremen2 1 0.01 0.06 0.04 5.00
5 INT242165 Wnt2 Positive_regulation of Gene_expression of Fzd1 1 0.15 0.26 0 5.00
6 INT242166 Fzd1 Positive_regulation of Positive_regulation of Wnt2 1 0.13 0.24 0 5.00
7 INT242159 Wnt2 Positive_regulation of Localization of Casp3 1 0.05 0.25 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Retinal Degeneration. They are ordered first by their pain relevance and then by number of times they were reported in Retinal Degeneration. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT242144 Regulation of Rp1 2 0.22 1.13 0.05 100.00
2 INT69203 Positive_regulation of Ntf3 43 0.66 19.16 16.49 99.92
3 INT73314 Gene_expression of Arc 133 0.78 67.78 27.44 99.80
4 INT48144 Gene_expression of Fgf2 117 0.78 43 20.48 99.80
5 INT64689 Positive_regulation of Gene_expression of Fgf2 30 0.70 12.05 6.2 99.80
6 INT328646 Gene_expression of Atp6v0a1 1 0.64 2.87 0.1 99.60
7 INT200750 Gene_expression of Rho 19 0.65 6.52 0.69 99.60
8 INT145229 Gene_expression of Rras 4 0.25 3.2 1.47 99.60
9 INT328645 Gene_expression of Rpl27a 3 0.22 1.72 0.43 99.60
10 INT273456 Gene_expression of Pkn3 8 0.06 3.32 0 99.46
11 INT328644 Gene_expression of Trav6n-6 1 0.01 1.68 0 99.46
12 INT242145 Regulation of Gene_expression of Sfrp1 1 0.17 0.99 0 99.44
13 INT273454 Gene_expression of Fat1 21 0.76 6.6 0.18 99.28
14 INT274112 Regulation of Phosphorylation of Rho 1 0.17 0.73 0.07 99.24
15 INT274111 Phosphorylation of Rho 1 0.39 0.73 0.07 99.24
16 INT61548 Positive_regulation of Fgf2 72 0.70 32.18 14.49 99.08
17 INT82650 Gene_expression of Bcl2 312 0.78 211.71 55.03 98.92
18 INT93734 Positive_regulation of Gene_expression of Bcl2 76 0.70 61.95 18.46 98.92
19 INT196916 Negative_regulation of Rb1 13 0.42 14.29 0.4 98.76
20 INT65207 Positive_regulation of Positive_regulation of Fgf2 10 0.70 3.5 2.08 98.56
21 INT273461 Gene_expression of Elovl4 15 0.75 4.21 0.08 98.48
22 INT16258 Gene_expression of Ntf3 121 0.78 53.93 59.03 98.46
23 INT85640 Gene_expression of Tg(CAG-EGFP)D4Nagy 1138 0.72 311.58 119.18 98.28
24 INT4459 Positive_regulation of Arc 74 0.69 33.61 28.29 98.24
25 INT119940 Positive_regulation of Gene_expression of Arc 36 0.70 18.87 7.85 98.24
26 INT242136 Gene_expression of Sfrp1 3 0.46 2.75 0.05 98.24
27 INT242146 Positive_regulation of Gene_expression of Sfrp1 2 0.30 1.68 0.05 98.24
28 INT28131 Regulation of Rho 2 0.62 0.5 0.42 97.72
29 INT114093 Regulation of Cish 4 0.20 1.77 0.42 97.20
30 INT6557 Gene_expression of Eno2 65 0.77 54.42 8.17 96.88
31 INT34870 Positive_regulation of OPA1 18 0.59 10.66 5 96.84
32 INT2520 Negative_regulation of Ca2 271 0.57 72.13 83.71 96.36
33 INT204795 Gene_expression of Xiap 9 0.60 15.32 0.7 96.20
34 INT32137 Regulation of Negative_regulation of Ca2 7 0.36 2.17 0.49 96.12
35 INT25906 Negative_regulation of Cish 6 0.29 5.41 3.17 95.84
36 INT242132 Localization of Sfrp2 3 0.70 5.01 0 94.88
37 INT274110 Negative_regulation of Rcvrn 1 0.12 0.69 0 93.96
38 INT49511 Regulation of Pde11a 4 0.22 1 0.53 93.20
39 INT204805 Regulation of Xiap 3 0.40 3.98 0.17 92.76
40 INT274108 Phosphorylation of Cdk5r1 1 0.01 0.84 0 92.60
41 INT204800 Binding of Xiap 1 0.43 3.39 0.03 91.60
42 INT1032 Regulation of Ca2 202 0.52 54.91 53.03 91.36
43 INT158863 Negative_regulation of Ros1 84 0.35 40.3 10.14 91.16
44 INT3131 Binding of Arc 5 0.34 2.68 0.94 91.12
45 INT63328 Binding of Fgf1 10 0.37 1.5 1.4 91.04
46 INT101083 Binding of Fgf2 14 0.42 4.12 3.14 91.04
47 INT1033 Positive_regulation of Ca2 507 0.68 131.76 147.64 90.92
48 INT24883 Regulation of OPA1 14 0.45 9.73 3.44 90.48
49 INT145993 Positive_regulation of Xiap 4 0.67 4.4 1.16 89.96
50 INT187295 Gene_expression of Serpinb1a 6 0.58 13.73 5.05 89.88
51 INT106096 Regulation of Localization of Arc 3 0.45 1.79 0.72 89.20
52 INT242153 Negative_regulation of Wnt2 19 0.49 11.87 1.37 87.28
53 INT125534 Regulation of Tg(CAG-EGFP)D4Nagy 31 0.39 13.88 5.58 87.16
54 INT106095 Localization of Arc 17 0.80 7.61 3.74 87.12
55 INT124374 Binding of Wnt2 21 0.31 10.16 0.99 87.08
56 INT124375 Gene_expression of Wnt2 67 0.56 38.03 4.67 86.36
57 INT209418 Negative_regulation of CLTA 2 0.06 1.62 0.03 85.28
58 INT54809 Regulation of TIMM13 2 0.14 2.31 0.07 81.76
59 INT328647 Negative_regulation of Pkn3 1 0.03 0.64 0 80.48
60 INT328642 Negative_regulation of Trav6n-6 1 0.00 0.57 0 80.48
61 INT201524 Localization of Wnt2 14 0.62 9.24 0.46 79.56
62 INT287344 Regulation of NDUFB11 1 0.01 0.33 0 79.36
63 INT54810 Negative_regulation of Positive_regulation of TIMM13 1 0.22 1.89 0.07 79.08
64 INT54811 Negative_regulation of TIMM13 2 0.22 2.46 0.07 79.08
65 INT124373 Positive_regulation of Gene_expression of Wnt2 14 0.42 8.28 0.6 78.96
66 INT54808 Positive_regulation of TIMM13 3 0.23 3.05 0.13 78.44
67 INT91158 Regulation of Ros1 26 0.25 17 4.23 78.00
68 INT274107 Negative_regulation of Phosphorylation of Npr1 1 0.08 0.32 0 76.60
69 INT274114 Negative_regulation of Phosphorylation of Pde11a 1 0.06 0.32 0 76.60
70 INT54807 Binding of MLLT1 4 0.11 2.96 0.22 76.24
71 INT101599 Gene_expression of Cdk5r1 5 0.63 1.27 1.68 75.72
72 INT155689 Phosphorylation of Ros1 6 0.32 5.1 4.36 75.68
73 INT283300 Transcription of Serpine2 1 0.06 0.67 0.25 74.44
74 INT283298 Transcription of Serpina1d 1 0.04 0.66 0.24 74.44
75 INT5569 Phosphorylation of Npr1 3 0.18 0.61 0.7 73.40
76 INT274115 Phosphorylation of Pde11a 1 0.12 0.61 0 73.40
77 INT242129 Gene_expression of Sfrp2 5 0.67 5.57 0.18 72.16
78 INT8989 Binding of Npr1 25 0.36 5.52 14.58 71.84
79 INT274113 Binding of Pde11a 1 0.05 0.3 0 71.84
80 INT169776 Gene_expression of Opn4 52 0.77 8.75 1.38 71.80
81 INT169778 Positive_regulation of Opn4 8 0.68 1.63 0.63 71.80
82 INT347090 Positive_regulation of Smarcc1 1 0.01 0.56 0.37 70.84
83 INT185886 Gene_expression of JUP 20 0.75 15.41 0.32 69.04
84 INT115528 Binding of Ros1 37 0.41 22.96 5.5 65.40
85 INT242130 Positive_regulation of Positive_regulation of Dkk1 2 0.49 1.71 0.33 63.92
86 INT111153 Positive_regulation of Dkk1 13 0.68 10.56 2.58 62.96
87 INT204809 Positive_regulation of Gene_expression of Xiap 1 0.45 1.6 0 54.76
88 INT235983 Gene_expression of Sag 3 0.58 6.47 0.16 50.84
89 INT274109 Gene_expression of Rcvrn 1 0.22 0.28 0 50.84
90 INT129883 Gene_expression of Dkk1 56 0.77 45.42 12.52 48.64
91 INT1559 Negative_regulation of Atp6v0a1 2 0.31 0.08 0.97 44.24
92 INT175580 Localization of APOE 10 0.76 18.84 0.65 42.60
93 INT204797 Positive_regulation of Gene_expression of Rho 1 0.14 1.11 0 42.08
94 INT188047 Positive_regulation of Wnt2 51 0.58 31.41 2.94 41.72
95 INT204236 Gene_expression of Rho 3 0.23 1.26 0.09 41.48
96 INT204447 Binding of Ncl 3 0.18 1.99 0.11 40.80
97 INT239386 Gene_expression of Atp7b 4 0.52 3.24 0.32 38.72
98 INT285051 Negative_regulation of Gene_expression of Atp7b 1 0.01 0.49 0 38.72
99 INT204801 Regulation of Positive_regulation of Rho 1 0.13 1.25 0 37.56
100 INT204803 Regulation of Binding of Rho 1 0.13 1.15 0 37.56
101 INT96269 Positive_regulation of Mcpt1 71 0.61 52.38 20.4 37.52
102 INT204799 Binding of Rho 2 0.12 1.2 0.3 37.08
103 INT204802 Positive_regulation of Binding of Rho 1 0.15 1.24 0 37.08
104 INT204804 Protein_catabolism of Xiap 1 0.59 2.27 0.03 36.96
105 INT5841 Gene_expression of Vim 181 0.72 138.54 16.33 34.96
106 INT97829 Gene_expression of Pdx1 7 0.32 1.14 0 34.96
107 INT93089 Positive_regulation of Rho 3 0.47 1.17 0.05 34.12
108 INT328648 Negative_regulation of Gene_expression of Rho 1 0.19 0.54 0 29.20
109 INT204018 Localization of Gsk3b 27 0.71 13.67 1.87 27.52
110 INT124371 Negative_regulation of Gsk3b 170 0.55 87.92 15.51 25.60
111 INT167284 Phosphorylation of Gsk3b 88 0.82 36.03 4.21 25.60
112 INT167283 Negative_regulation of Phosphorylation of Gsk3b 12 0.59 7.94 1.16 25.60
113 INT173878 Gene_expression of ACAN 32 0.75 9.35 3.55 24.12
114 INT9655 Regulation of Il6 98 0.62 70.92 31.95 21.96
115 INT83955 Regulation of Cxcl2 14 0.58 9.77 4.45 21.96
116 INT204807 Negative_regulation of Binding of Kcnj11 1 0.03 1.9 0.03 20.56
117 INT204806 Negative_regulation of Binding of Xiap 1 0.38 1.91 0.03 20.56
118 INT111156 Negative_regulation of Dkk1 21 0.58 20.08 4.27 19.76
119 INT204808 Binding of Kcnj11 3 0.04 3.28 0.07 19.36
120 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 18.72
121 INT83953 Gene_expression of Cxcl2 140 0.75 113.07 43.65 18.20
122 INT173655 Binding of LRP5 10 0.39 3.06 0.22 16.48
123 INT71602 Negative_regulation of Trp53 84 0.59 67.77 3.68 16.40
124 INT64233 Regulation of Trp53 35 0.62 27.11 1.53 16.40
125 INT8243 Positive_regulation of Il6 451 0.70 358.24 119.28 10.80
126 INT229153 Gene_expression of Esyt2 12 0.21 2.14 3.76 10.32
127 INT135372 Positive_regulation of Gsk3b 72 0.70 50.03 9.28 6.08
128 INT167285 Positive_regulation of Phosphorylation of Gsk3b 17 0.50 5.92 0.82 6.08
129 INT7114 Positive_regulation of Ltp 1192 0.62 290.76 755.77 5.00
130 INT9131 Positive_regulation of Prkcg 431 0.70 130.8 302.41 5.00
131 INT22548 Positive_regulation of Casp3 483 0.70 258.78 213.07 5.00
132 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 5.00
133 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 5.00
134 INT7627 Negative_regulation of Positive_regulation of Ltp 162 0.50 41.2 106.27 5.00
135 INT12763 Phosphorylation of Prkcg 167 0.82 38.91 89.63 5.00
136 INT62374 Gene_expression of NGF 158 0.78 77.87 76.45 5.00
137 INT6486 Positive_regulation of Tnf 168 0.70 123.47 66.05 5.00
138 INT169926 Positive_regulation of Gopc 416 0.46 157.8 58.67 5.00
139 INT13277 Regulation of Positive_regulation of Ltp 83 0.52 19.68 55.78 5.00
140 INT72182 Gene_expression of Mcpt1 167 0.75 123.7 52.15 5.00
141 INT77307 Gene_expression of Bcl2 399 0.77 319.77 38 5.00
142 INT6660 Positive_regulation of Jun 148 0.69 67.58 29.73 5.00
143 INT47712 Positive_regulation of App 135 0.69 101.38 28.94 5.00
144 INT58301 Positive_regulation of Mpo 87 0.70 80.19 23.99 5.00
145 INT61116 Positive_regulation of Ppara 119 0.69 58.62 21.6 5.00
146 INT3060 Negative_regulation of Bche 94 0.59 46.75 18.51 5.00
147 INT61519 Gene_expression of Mpo 112 0.78 89.29 18.22 5.00
148 INT110767 Localization of Mcpt1 43 0.68 24.3 16.74 5.00
149 INT61117 Gene_expression of Ppara 158 0.68 69.3 15.98 5.00
150 INT109535 Gene_expression of Vegfa 116 0.75 84.61 14.89 5.00
151 INT124372 Gene_expression of Gsk3b 164 0.75 95.64 14.35 5.00
152 INT107916 Protein_catabolism of App 114 1.00 66.71 12.38 5.00
153 INT150851 Positive_regulation of Cxcl1 45 0.57 20.83 11.88 5.00
154 INT81640 Positive_regulation of Gene_expression of Bcl2 106 0.69 84.58 11.63 5.00
155 INT104441 Binding of NOVA2 72 0.42 16.41 10.51 5.00
156 INT35284 Positive_regulation of Chrm1 14 0.67 5.64 10.11 5.00
157 INT112967 Regulation of Mcpt1 15 0.54 13.03 8.58 5.00
158 INT148703 Gene_expression of NOVA2 73 0.65 18.05 8.3 5.00
159 INT127378 Localization of Mpo 21 0.78 26.36 8.28 5.00
160 INT98178 Localization of Casp3 32 0.65 21.01 7.77 5.00
161 INT68299 Binding of Tnf 17 0.39 12.55 7.49 5.00
162 INT90545 Phosphorylation of Siglec1 53 0.11 12.09 6.81 5.00
163 INT170922 Binding of Ppara 59 0.45 28.45 6.7 5.00
164 INT124370 Positive_regulation of Gene_expression of Gsk3b 47 0.67 24.56 5.4 5.00
165 INT87022 Gene_expression of Apc 68 0.67 46.98 5.22 5.00
166 INT170927 Negative_regulation of Ppara 27 0.54 13.58 5.12 5.00
167 INT161220 Binding of Ccl2 17 0.46 17.63 4.94 5.00
168 INT135374 Binding of Gsk3b 46 0.48 24.36 4.75 5.00
169 INT110768 Transcription of Mcpt1 12 0.52 7.66 4.71 5.00
170 INT72703 Gene_expression of Ide 79 0.70 45.04 4.47 5.00
171 INT74374 Negative_regulation of Phosphorylation of Prkcg 7 0.41 1.28 3.57 5.00
172 INT135373 Regulation of Gsk3b 35 0.62 18.11 3.53 5.00
173 INT124606 Positive_regulation of Gene_expression of Mpo 14 0.49 12.66 3.24 5.00
174 INT101959 Regulation of Rorb 10 0.14 5.18 3.17 5.00
175 INT181668 Protein_catabolism of Prkcg 8 0.77 2.59 3.06 5.00
176 INT58302 Regulation of Mpo 13 0.62 11.14 3.04 5.00
177 INT98686 Gene_expression of Calb2 28 0.51 12.07 2.84 5.00
178 INT147429 Negative_regulation of Positive_regulation of App 8 0.40 8.73 2.78 5.00
179 INT5844 Positive_regulation of Gene_expression of Vim 14 0.25 9.64 2.18 5.00
180 INT3818 Regulation of Apc 13 0.39 12.52 1.68 5.00
181 INT185649 Regulation of ERG 17 0.20 10.14 1.49 5.00
182 INT125733 Positive_regulation of Positive_regulation of Mcpt1 6 0.44 3.79 1.38 5.00
183 INT220177 Binding of Apc 21 0.37 15.34 1.37 5.00
184 INT169907 Gene_expression of Rb1 25 0.60 21.95 1.32 5.00
185 INT79358 Gene_expression of ERVW-1 65 0.75 29.9 1.31 5.00
186 INT192982 Binding of Calb2 8 0.33 1.61 1.22 5.00
187 INT11109 Positive_regulation of Serpina1a 5 0.68 4.97 1.12 5.00
188 INT132551 Negative_regulation of Plxna2 3 0.36 0.86 1.11 5.00
189 INT208536 Positive_regulation of Positive_regulation of Gsk3b 6 0.30 4.83 1.11 5.00
190 INT144427 Transcription of Ccnd1 10 0.41 7.89 1.07 5.00
191 INT224722 Binding of Mcpt1 6 0.10 4.82 1.03 5.00
192 INT242171 Protein_catabolism of JUP 4 0.96 0.91 1.01 5.00
193 INT158651 Gene_expression of Plxna2 9 0.66 1.98 0.98 5.00
194 INT242152 Transcription of Wnt2 8 0.57 5.22 0.88 5.00
195 INT242134 Localization of Apc 8 0.74 4.83 0.88 5.00
196 INT215259 Negative_regulation of Siglec1 5 0.14 3.82 0.87 5.00
197 INT156945 Positive_regulation of Negative_regulation of Gsk3b 6 0.38 4.58 0.82 5.00
198 INT242131 Localization of Dkk1 5 0.79 6 0.76 5.00
199 INT129882 Positive_regulation of Gene_expression of Dkk1 4 0.69 4.62 0.72 5.00
200 INT242137 Negative_regulation of Positive_regulation of Gsk3b 7 0.39 2.99 0.67 5.00
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