D:Retinal Perforations

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Disease Term
Synonyms BREAK RETINAL, BREAKS RETINAL, Dialyses Retinal, Hole Macular, Hole Retinal, HOLES MACULAR, Holes Retinal, Macular Hole, Macular Holes, Perforation Retinal, Perforations Retinal
Documents 79
Hot Single Events 15
Hot Interactions 1

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Retinal Perforations. They are ordered first by their relevance to Retinal Perforations and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT353109 Binding of VEGFA and Aes 1 0.02 3.93 0.43 88.88
2 INT288026 PROC Positive_regulation of Gene_expression of VEGFA 1 0.01 0.5 0.15 24.56
3 INT259556 PLEK Negative_regulation of Gene_expression of VEGFA 1 0.46 2.15 0.73 5.00
4 INT259557 PLEK Negative_regulation of Positive_regulation of VEGFA 1 0.46 2.15 0.73 5.00
5 INT255690 Binding of VEGFA and Flt1 8 0.34 3.44 0.61 5.00
6 INT283714 Positive_regulation of Binding of Id2 and Homer1 1 0.08 1.34 0.42 5.00
7 INT283713 Binding of Id2 and Homer1 1 0.06 1.34 0.42 5.00
8 INT287380 Binding of VEGFA and Kdr 12 0.18 11.97 0.34 5.00
9 INT283719 Id2 Regulation of Regulation of Hes7 1 0.00 0.31 0.12 5.00
10 INT283710 Binding of Id2 and Hes7 1 0.01 0.13 0.11 5.00
11 INT287381 Cxcl2 Regulation of Gene_expression of VEGFA 1 0.42 1.1 0.1 5.00
12 INT283721 Binding of Lpin1 and Id2 1 0.38 0.18 0.08 5.00
13 INT353105 Binding of Aes and Rgs9bp 1 0.01 0.35 0.05 5.00
14 INT288025 VEGFA Regulation of IL6 1 0.36 0.26 0.03 5.00
15 INT288027 VEGFA Regulation of CCL2 1 0.44 0.26 0.03 5.00
16 INT283720 Id2 Negative_regulation of Transcription of Cdkn2b 1 0.18 0.11 0.03 5.00
17 INT288028 VEGFA Regulation of IL8 1 0.36 0.26 0.03 5.00
18 INT283722 Id2 Negative_regulation of Transcription of CDKN1A 1 0.45 0.11 0.03 5.00
19 INT283712 Id2 Regulation of Gene_expression of Fos 1 0.43 0 0.03 5.00
20 INT353104 Binding of amd and Gtf3a 1 0.01 1.53 0.03 5.00
21 INT346947 Binding of VEGFA and amd 1 0.01 0.1 0 5.00
22 INT283715 Lpin1 Regulation of 4930579C15Rik 1 0.35 0.74 0 5.00
23 INT353106 Binding of amd and C3 1 0.09 1.69 0 5.00
24 INT353108 Binding of VEGFA and Pgf 1 0.02 2.17 0 5.00
25 INT353107 Binding of VEGFA and Vegfb 1 0.02 1.08 0 5.00
26 INT243233 Positive_regulation of Ighmbp2 Negative_regulation of Rs1 1 0.11 0.31 0 5.00
27 INT283717 Id2 Regulation of 4930579C15Rik 1 0.15 0.75 0 5.00
28 INT283718 Binding of Id2 and Aatf 1 0.03 0.19 0 5.00
29 INT353110 Binding of VEGFA and Eo 1 0.00 0.67 0 5.00
30 INT243235 Ighmbp2 Negative_regulation of Rs1 1 0.11 0.31 0 5.00
31 INT273772 BCKDHA Positive_regulation of Positive_regulation of NARFL 1 0.03 1.21 0 5.00
32 INT243232 Ighmbp2 Negative_regulation of Ptch1 1 0.02 0.22 0 5.00
33 INT283716 Neurod1 Positive_regulation of Pax6 1 0.23 0.46 0 5.00
34 INT283711 Sox11 Regulation of 4930579C15Rik 1 0.28 0.74 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Retinal Perforations. They are ordered first by their pain relevance and then by number of times they were reported in Retinal Perforations. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT129610 Gene_expression of Id2 7 0.74 17.07 1.69 99.48
2 INT211548 Gene_expression of Lpin1 9 0.76 12.83 0.96 99.32
3 INT297602 Positive_regulation of Tsv 3 0.07 3.36 0.33 96.36
4 INT239498 Localization of Aes 2 0.58 2.22 0.4 94.16
5 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 93.72
6 INT40698 Positive_regulation of Aes 3 0.32 3.84 0.65 91.92
7 INT29 Negative_regulation of Gast 74 0.59 24.85 24.96 91.12
8 INT1767 Positive_regulation of PROC 83 0.67 54.14 17 88.52
9 INT159060 Localization of PDR 8 0.65 10.45 0.96 87.08
10 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 83.68
11 INT86111 Positive_regulation of Positive_regulation of VEGFA 38 0.69 33.81 5.78 83.68
12 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 83.68
13 INT67981 Positive_regulation of CCL2 165 0.70 136.84 61.85 82.40
14 INT48692 Binding of VEGFA 345 0.48 210.3 21.31 81.88
15 INT288032 Negative_regulation of Localization of PDR 1 0.20 1.24 0.19 81.68
16 INT353099 Positive_regulation of Ctrcts 1 0.01 1.63 0.16 79.56
17 INT79395 Gene_expression of Twist1 193 0.77 100.06 26.34 77.76
18 INT283698 Gene_expression of Sox11 1 0.68 4.6 0.33 76.04
19 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 73.76
20 INT10838 Positive_regulation of IL8 381 0.70 295.51 101.62 73.52
21 INT134968 Localization of Ecm1 20 0.32 27.27 4.31 70.84
22 INT197973 Localization of Col4a1 2 0.73 2.15 0.26 70.84
23 INT283699 Positive_regulation of Sox11 1 0.35 0.62 0 69.92
24 INT80939 Positive_regulation of PDR 8 0.55 5.43 0.67 67.24
25 INT157378 Gene_expression of PDR 14 0.53 11.46 0.64 66.32
26 INT3777 Positive_regulation of NARFL 256 0.56 302.43 25.74 59.56
27 INT273474 Positive_regulation of Gene_expression of Lefty1 1 0.01 1.61 0.26 54.88
28 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 53.76
29 INT76892 Gene_expression of FGFR1 45 0.69 23.6 7.56 53.76
30 INT172959 Gene_expression of Lefty1 4 0.21 5.15 0.76 53.76
31 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53 50.40
32 INT136664 Positive_regulation of Gene_expression of Twist1 49 0.69 25.91 5.41 49.32
33 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 47.32
34 INT262796 Positive_regulation of Pycard 12 0.22 6.5 0.14 46.44
35 INT9647 Gene_expression of PROC 163 0.65 89.76 26.75 41.28
36 INT19153 Gene_expression of lec 7 0.59 2.89 0.69 38.44
37 INT134967 Gene_expression of Ecm1 66 0.29 38.4 7.16 38.28
38 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 36.64
39 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 36.48
40 INT267196 Gene_expression of Cryab 17 0.64 22.5 0.38 36.32
41 INT283701 Gene_expression of Crygd 1 0.47 2.23 0.18 36.32
42 INT283706 Gene_expression of Cryba4 1 0.56 2.22 0.18 36.32
43 INT55879 Gene_expression of CCL2 421 0.78 240.74 166.02 36.04
44 INT346946 Regulation of Negative_regulation of amd 1 0.05 0.57 0.3 35.00
45 INT239497 Binding of Aes 8 0.29 3.61 0.84 32.88
46 INT139862 Negative_regulation of amd 8 0.35 10.15 0.6 32.52
47 INT68683 Regulation of Gene_expression of VEGFA 143 0.62 104.19 20.14 28.68
48 INT12339 Localization of IL8 437 0.81 251.87 117.39 24.04
49 INT12082 Localization of IL6 365 0.81 241.78 105.78 24.04
50 INT101992 Localization of VEGFA 413 0.81 258.23 36.15 24.04
51 INT65698 Localization of CCL2 118 0.81 77.54 32.69 24.04
52 INT130358 Gene_expression of Tsp2 8 0.65 4.84 0.67 20.32
53 INT173693 Localization of Gopc 249 0.65 70.49 38.81 19.44
54 INT5379 Gene_expression of Fos 656 0.78 255.5 292.54 5.00
55 INT5010 Gene_expression of Calca 197 0.78 85.76 118.75 5.00
56 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 5.00
57 INT11807 Gene_expression of Il2 266 0.78 112 64.97 5.00
58 INT9657 Positive_regulation of Gene_expression of Il6 237 0.70 180.45 63.6 5.00
59 INT9210 Regulation of IL6 166 0.62 125.61 49.95 5.00
60 INT83953 Gene_expression of Cxcl2 140 0.75 113.07 43.65 5.00
61 INT170054 Negative_regulation of Gopc 280 0.38 117.89 42.4 5.00
62 INT30 Gene_expression of Gast 158 0.78 99 41.45 5.00
63 INT60710 Gene_expression of Col7a1 217 0.78 113.2 35.2 5.00
64 INT14559 Gene_expression of Igf1 254 0.78 112 34.17 5.00
65 INT99688 Negative_regulation of Gene_expression of VEGFA 274 0.58 201.8 31.1 5.00
66 INT66200 Gene_expression of Gfap 215 0.78 88.04 28.25 5.00
67 INT16428 Positive_regulation of Gtf3a 135 0.20 106.44 26.67 5.00
68 INT10835 Regulation of IL8 79 0.49 53.04 24.14 5.00
69 INT47818 Positive_regulation of Homer1 48 0.70 11.11 24.05 5.00
70 INT14556 Positive_regulation of Igf1 105 0.69 52.21 24.04 5.00
71 INT4535 Localization of PROC 106 0.73 76.24 21.1 5.00
72 INT78901 Localization of CCL5 67 0.78 40.79 20.59 5.00
73 INT56749 Gene_expression of PCNA 219 0.77 111.25 18.42 5.00
74 INT66857 Regulation of CCL2 39 0.53 28.55 18.35 5.00
75 INT11275 Regulation of Fos 37 0.60 5.79 18.18 5.00
76 INT35998 Positive_regulation of Gene_expression of Calca 31 0.70 16.16 16.98 5.00
77 INT21532 Negative_regulation of Gene_expression of Il2 47 0.59 20.43 16.96 5.00
78 INT1981 Negative_regulation of NARFL 219 0.47 223.48 16.41 5.00
79 INT87823 Positive_regulation of Cxcl2 51 0.66 35.47 14.79 5.00
80 INT65263 Positive_regulation of Gene_expression of Igf1 61 0.69 25.69 14.49 5.00
81 INT1982 Regulation of NARFL 119 0.49 116.2 14.35 5.00
82 INT26545 Gene_expression of Hras1 173 0.78 79.54 13.21 5.00
83 INT12135 Gene_expression of PLEK 62 0.75 34.13 12.47 5.00
84 INT57187 Positive_regulation of Gfap 49 0.69 27.59 11.46 5.00
85 INT101203 Negative_regulation of Gene_expression of Calca 12 0.59 7.06 10.72 5.00
86 INT100379 Positive_regulation of HIF1A 69 0.69 57.31 10.4 5.00
87 INT101474 Positive_regulation of Gene_expression of Gfap 61 0.70 38.3 10.35 5.00
88 INT2036 Localization of EGF 42 0.77 21.5 9.74 5.00
89 INT62919 Regulation of Gnas 22 0.43 5.61 9.55 5.00
90 INT114874 Gene_expression of Stat3 78 0.76 53.99 9.49 5.00
91 INT11047 Positive_regulation of Positive_regulation of IL6 45 0.66 28.7 9.37 5.00
92 INT591 Negative_regulation of Serpinc1 44 0.57 31.73 8.82 5.00
93 INT104388 Positive_regulation of Gene_expression of Cxcl2 31 0.66 25.68 7.49 5.00
94 INT10131 Gene_expression of Serpinf1 53 0.76 35.57 6.42 5.00
95 INT75832 Positive_regulation of Positive_regulation of IL8 30 0.70 20.77 6.05 5.00
96 INT18681 Gene_expression of Thy1 80 0.71 38.8 5.23 5.00
97 INT105393 Positive_regulation of Localization of VEGFA 66 0.70 45.45 4.9 5.00
98 INT26167 Positive_regulation of Hrasls 18 0.23 8.67 4.87 5.00
99 INT99690 Negative_regulation of Positive_regulation of VEGFA 30 0.58 14.56 4.79 5.00
100 INT98357 Binding of Gnas 11 0.41 1.87 4.35 5.00
101 INT72747 Localization of IgG 55 0.53 30.88 4.19 5.00
102 INT15001 Localization of Gfap 29 0.75 6.71 4.1 5.00
103 INT94303 Gene_expression of Upf1 44 0.04 11.62 3.87 5.00
104 INT142174 Regulation of Gene_expression of Igf1 28 0.60 11.86 3.77 5.00
105 INT86369 Positive_regulation of Gene_expression of PCNA 40 0.67 26.66 3.57 5.00
106 INT10132 Negative_regulation of Serpinf1 14 0.58 11.72 3.14 5.00
107 INT114276 Gene_expression of Nr4a1 20 0.77 7.71 3.14 5.00
108 INT114878 Positive_regulation of Gene_expression of Stat3 15 0.49 10.81 2.91 5.00
109 INT4114 Gene_expression of Srf 9 0.70 6.11 2.63 5.00
110 INT5180 Binding of Serpinc1 27 0.36 13.39 2.47 5.00
111 INT101475 Regulation of Gene_expression of Gfap 8 0.62 4.77 1.96 5.00
112 INT130560 Negative_regulation of Gene_expression of Serpinf1 17 0.58 13.39 1.94 5.00
113 INT67980 Positive_regulation of Positive_regulation of CCL2 7 0.49 5.89 1.85 5.00
114 INT105162 Gene_expression of Ad 47 0.12 46.53 1.83 5.00
115 INT258848 Regulation of Gene_expression of Cxcl2 7 0.43 8.71 1.77 5.00
116 INT134965 Negative_regulation of Ecm1 7 0.18 7.86 1.7 5.00
117 INT33393 Positive_regulation of Gene_expression of PLEK 9 0.67 7.35 1.65 5.00
118 INT255663 Binding of Flt1 11 0.32 6.92 1.64 5.00
119 INT9953 Positive_regulation of Gnas 10 0.34 3.21 1.51 5.00
120 INT185649 Regulation of ERG 17 0.20 10.14 1.49 5.00
121 INT59837 Regulation of Upf1 5 0.03 1.37 1.45 5.00
122 INT10873 Localization of Twist1 21 0.74 10.43 1.37 5.00
123 INT24519 Negative_regulation of ERG 15 0.38 6.98 1.33 5.00
124 INT272274 Localization of NARFL 24 0.60 27.55 1.18 5.00
125 INT228770 Gene_expression of amd 16 0.57 21.49 1.05 5.00
126 INT209912 Gene_expression of Pycard 17 0.22 12.04 1.04 5.00
127 INT99966 Negative_regulation of Positive_regulation of NARFL 13 0.37 13.32 0.98 5.00
128 INT158651 Gene_expression of Plxna2 9 0.66 1.98 0.98 5.00
129 INT58755 Binding of PAM 6 0.34 3.09 0.97 5.00
130 INT139863 Binding of amd 27 0.41 41.3 0.91 5.00
131 INT255622 Positive_regulation of PAM 7 0.18 4.89 0.87 5.00
132 INT29636 Localization of PAM 5 0.73 2.1 0.87 5.00
133 INT272275 Regulation of Positive_regulation of NARFL 8 0.36 16.68 0.86 5.00
134 INT123154 Positive_regulation of Gene_expression of Thy1 7 0.53 4.34 0.86 5.00
135 INT140794 Gene_expression of Smad3 22 0.64 9.41 0.83 5.00
136 INT70744 Regulation of CFH 12 0.41 7.38 0.8 5.00
137 INT173082 Positive_regulation of Binding of VEGFA 20 0.48 11.16 0.79 5.00
138 INT103672 Localization of Serpinf1 4 0.69 2.45 0.74 5.00
139 INT123955 Regulation of Nr4a1 4 0.45 1.01 0.74 5.00
140 INT128329 Gene_expression of Cigs1 3 0.07 1.41 0.7 5.00
141 INT10130 Positive_regulation of Serpinf1 10 0.53 5.62 0.7 5.00
142 INT63765 Gene_expression of Add3 3 0.09 0.69 0.68 5.00
143 INT287127 Gene_expression of Omd 6 0.39 1.63 0.67 5.00
144 INT178489 Negative_regulation of Kdr 31 0.42 25.65 0.66 5.00
145 INT103673 Positive_regulation of Gene_expression of Serpinf1 13 0.60 4.94 0.64 5.00
146 INT174868 Regulation of Negative_regulation of VEGFA 4 0.43 4.51 0.63 5.00
147 INT123153 Positive_regulation of Thy1 14 0.47 4.13 0.6 5.00
148 INT200754 Gene_expression of Rpe 35 0.51 6.3 0.58 5.00
149 INT129615 Positive_regulation of Id2 2 0.66 2.22 0.57 5.00
150 INT230676 Gene_expression of 4930579C15Rik 13 0.34 5.61 0.49 5.00
151 INT9020 Binding of Tsv 2 0.25 1.28 0.48 5.00
152 INT200193 Gene_expression of Col4a4 8 0.12 5.75 0.43 5.00
153 INT283683 Binding of Id2 5 0.35 0.8 0.35 5.00
154 INT200373 Binding of Omd 7 0.34 7.03 0.34 5.00
155 INT209911 Protein_catabolism of Pycard 2 0.11 1.58 0.33 5.00
156 INT82797 Transcription of CDKN1A 11 0.69 8.01 0.32 5.00
157 INT18821 Positive_regulation of Gene_expression of Srf 2 0.35 0.63 0.31 5.00
158 INT243226 Positive_regulation of Rs1 3 0.70 5.6 0.31 5.00
159 INT215454 Regulation of amd 4 0.38 8.07 0.29 5.00
160 INT184825 Regulation of Thy1 7 0.42 4.14 0.28 5.00
161 INT7610 Localization of Srf 3 0.67 0.98 0.27 5.00
162 INT108763 Gene_expression of Cd81 3 0.59 1.12 0.27 5.00
163 INT210228 Positive_regulation of Rpe 15 0.52 8.78 0.26 5.00
164 INT262797 Regulation of Gene_expression of Smad3 2 0.34 2.27 0.25 5.00
165 INT216978 Binding of Pycard 6 0.25 2.93 0.22 5.00
166 INT283693 Transcription of Lpin1 1 0.67 1.31 0.22 5.00
167 INT108300 Positive_regulation of BCKDHA 3 0.39 1.74 0.18 5.00
168 INT283692 Gene_expression of Adi1 1 0.59 0.91 0.17 5.00
169 INT243222 Gene_expression of Rs1 6 0.78 8.49 0.17 5.00
170 INT267193 Positive_regulation of Gene_expression of Cryab 6 0.41 5.71 0.17 5.00
171 INT229940 Positive_regulation of amd 10 0.49 27.97 0.15 5.00
172 INT147818 Localization of amd 3 0.60 4.04 0.14 5.00
173 INT283702 Transcription of Id2 1 0.66 0.64 0.13 5.00
174 INT283678 Regulation of Hes7 1 0.00 0.25 0.12 5.00
175 INT211536 Binding of Lpin1 2 0.46 1.06 0.12 5.00
176 INT260172 Localization of Rpe 11 0.49 3.53 0.12 5.00
177 INT283708 Localization of Id2 2 0.71 0.72 0.11 5.00
178 INT243231 Localization of Rs1 2 0.67 2.15 0.1 5.00
179 INT243228 Protein_catabolism of Ighmbp2 3 0.16 0.83 0.1 5.00
180 INT250519 Negative_regulation of Igf1r 5 0.42 2.7 0.09 5.00
181 INT283695 Binding of Sox11 1 0.32 0.18 0.08 5.00
182 INT283675 Binding of Adi1 1 0.28 0.18 0.08 5.00
183 INT283679 Positive_regulation of Lpin1 1 0.48 0.57 0.07 5.00
184 INT346651 Gene_expression of Tsv 1 0.10 0.59 0.06 5.00
185 INT283677 Localization of Lpin1 1 0.32 0.37 0.05 5.00
186 INT283696 Localization of Sox11 1 0.65 0.37 0.05 5.00
187 INT283685 Localization of Adi1 1 0.57 0.37 0.05 5.00
188 INT243229 Localization of Xmmv63 1 0.73 1.18 0.04 5.00
189 INT243221 Positive_regulation of Localization of Xmmv63 1 0.49 1.19 0.04 5.00
190 INT262801 Regulation of Gene_expression of Pycard 1 0.08 1.8 0.04 5.00
191 INT99965 Positive_regulation of Negative_regulation of NARFL 6 0.40 4.5 0.04 5.00
192 INT243230 Positive_regulation of Localization of Rs1 1 0.44 1.18 0.04 5.00
193 INT262794 Positive_regulation of Negative_regulation of Ecm1 1 0.04 1.07 0.04 5.00
194 INT262799 Localization of Smad3 6 0.56 2.09 0.04 5.00
195 INT243225 Binding of Rs1 2 0.33 1.32 0.03 5.00
196 INT353103 Positive_regulation of ARMS2 1 0.05 1.47 0.03 5.00
197 INT139470 Positive_regulation of Htra1 2 0.48 1.58 0.03 5.00
198 INT353097 Positive_regulation of Plekha1 1 0.34 1.47 0.03 5.00
199 INT184722 Positive_regulation of Smad3 3 0.47 1.22 0.03 5.00
200 INT283680 Regulation of Gene_expression of 4930579C15Rik 1 0.14 0.91 0.03 5.00
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