D:Retinopathy

From wiki-pain
Jump to: navigation, search

pChart

Disease Term
Synonyms Age Related Macular Degeneration, Age Related Macular Degeneration Diabetic Retinopathy, CENTRAL RETINAL ARTERY OCCLUSION, Central Vein Occlusion, Diabetic Retinopathies, Diabetic Retinopathy, Hypertensive Retinopathy, Premature Retinopathy, RETINAL DETACHMENT, Retinitis Pigmentosa, Retinopathies Diabetic
Documents 114
Hot Single Events 16
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Retinopathy. They are ordered first by their relevance to Retinopathy and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT260496 Hif1a Regulation of Gene_expression of VEGFA 1 0.12 0.93 0 46.80
2 INT301054 Tfap2a Regulation of Gene_expression of Faslg 1 0.00 1.23 0.34 42.88
3 INT144035 IL6 Positive_regulation of STAT3 4 0.31 2.58 0.56 5.00
4 INT252357 Binding of THBS1 and Cd36 2 0.01 2.4 0.21 5.00
5 INT173430 Binding of FLT4 and VEGFA 10 0.25 9.38 0.19 5.00
6 INT298641 PPARA Regulation of STAT3 1 0.23 0.98 0.16 5.00
7 INT298639 GDE1 Negative_regulation of AKT1 1 0.00 1.14 0.14 5.00
8 INT260495 VEGFA Positive_regulation of Grin1 1 0.08 1.08 0.12 5.00
9 INT260497 VEGFA Positive_regulation of Gria2 1 0.03 1.08 0.12 5.00
10 INT298634 Binding of IL6 and STAT3 1 0.04 1.41 0.08 5.00
11 INT298638 IL6 Positive_regulation of IL6R 1 0.00 0.9 0.05 5.00
12 INT298635 PPARA Negative_regulation of Localization of ZDHHC2 1 0.01 0.21 0.05 5.00
13 INT298683 ecs Positive_regulation of Gene_expression of VEGFA 1 0.02 1.41 0.04 5.00
14 INT298637 ZDHHC2 Negative_regulation of Gene_expression of VEGFA 1 0.01 0.27 0.04 5.00
15 INT298633 STAT3 Regulation of MCL1 1 0.04 0.85 0.03 5.00
16 INT298640 IL6R Positive_regulation of STAT3 1 0.01 0.73 0.03 5.00
17 INT235800 Twist1 Positive_regulation of VEGFA 1 0.02 0.62 0.03 5.00
18 INT298684 ecs Positive_regulation of Gene_expression of KDR 1 0.01 1.2 0 5.00
19 INT325099 Dbp Positive_regulation of Gene_expression of Tg(CAG-EGFP)D4Nagy 1 0.00 0.14 0 5.00
20 INT144032 STAT3 Regulation of BCL2 2 0.07 0.86 0 5.00
21 INT298632 STAT3 Positive_regulation of MIR21 1 0.03 0.84 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Retinopathy. They are ordered first by their pain relevance and then by number of times they were reported in Retinopathy. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 99.64
2 INT10448 Positive_regulation of Srf 3 0.47 0.89 1.03 99.12
3 INT4114 Gene_expression of Srf 9 0.70 6.11 2.63 98.72
4 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 98.04
5 INT26795 Gene_expression of Mtpn 44 0.62 27.66 8.62 98.04
6 INT139261 Positive_regulation of Gene_expression of Mtpn 8 0.05 5.95 1.22 98.04
7 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 97.68
8 INT249914 Positive_regulation of Epas1 2 0.19 2.42 0.05 94.84
9 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53 93.40
10 INT55899 Positive_regulation of Ptafr 6 0.63 4.7 1.34 93.16
11 INT54701 Localization of Ptafr 19 0.49 18.68 3.82 92.40
12 INT86111 Positive_regulation of Positive_regulation of VEGFA 38 0.69 33.81 5.78 90.80
13 INT48692 Binding of VEGFA 345 0.48 210.3 21.31 90.64
14 INT144843 Regulation of Gmcl1 5 0.37 2.76 1.15 90.16
15 INT68683 Regulation of Gene_expression of VEGFA 143 0.62 104.19 20.14 83.84
16 INT243244 Localization of Gmcl1 2 0.53 1.61 0.37 81.84
17 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07 76.12
18 INT99688 Negative_regulation of Gene_expression of VEGFA 274 0.58 201.8 31.1 75.40
19 INT11699 Binding of HLA-E 85 0.47 52.51 13.41 74.96
20 INT260525 Gene_expression of AMD1 25 0.66 24.58 1.32 72.96
21 INT95787 Positive_regulation of Mapk1 568 0.70 226.51 220.94 71.60
22 INT95788 Positive_regulation of Positive_regulation of Mapk1 83 0.69 24.75 25.84 71.60
23 INT95414 Positive_regulation of Alms1 40 0.41 20.3 8.1 71.28
24 INT7533 Gene_expression of Tlr4 720 0.78 343.22 121.57 66.92
25 INT78057 Localization of Tlr4 140 0.77 67.75 21.72 66.92
26 INT260480 Transcription of Gsk3b 1 0.02 3.08 0 64.88
27 INT122597 Transcription of Hif1a 5 0.69 5.56 1.63 64.88
28 INT134758 Positive_regulation of Transcription of Hif1a 2 0.33 2.44 0.53 64.88
29 INT112704 Positive_regulation of Hif1a 25 0.67 21.49 4.23 63.72
30 INT66366 Positive_regulation of Gsk3b 15 0.68 6.56 4.27 63.72
31 INT269748 Positive_regulation of AMD1 4 0.43 3.56 0.28 63.44
32 INT122195 Regulation of Localization of VEGFA 13 0.57 10.61 1.92 63.40
33 INT101992 Localization of VEGFA 413 0.81 258.23 36.15 62.76
34 INT5114 Gene_expression of Ptgis 41 0.50 21.43 8.1 58.00
35 INT15917 Positive_regulation of Gene_expression of Ptgis 5 0.35 3.69 0.95 58.00
36 INT158416 Localization of Mapk1 19 0.67 5.32 4.18 56.32
37 INT22112 Positive_regulation of Localization of TNF 164 0.70 115.66 52.18 55.08
38 INT6852 Localization of TNF 883 0.81 705.95 270.84 54.40
39 INT16428 Positive_regulation of Gtf3a 135 0.20 106.44 26.67 53.44
40 INT19449 Binding of FANCB 22 0.47 7.4 4.27 53.20
41 INT15896 Gene_expression of FANCB 18 0.65 6.44 1.18 52.48
42 INT134756 Positive_regulation of Gene_expression of Hif1a 8 0.50 11.14 2.68 51.76
43 INT112713 Gene_expression of Hif1a 24 0.75 20.48 5.45 51.36
44 INT100821 Localization of Ros1 59 0.60 45.26 11.92 51.04
45 INT86851 Gene_expression of Faslg 45 0.75 24.42 9.21 42.88
46 INT109535 Gene_expression of Vegfa 116 0.75 84.61 14.89 42.84
47 INT43820 Positive_regulation of Twist1 75 0.59 42.15 8.47 41.12
48 INT138287 Gene_expression of Map2k1 69 0.65 46.14 1.02 39.48
49 INT281764 Negative_regulation of Gene_expression of Map2k1 1 0.18 1.11 0.04 39.48
50 INT181525 Localization of Il13 24 0.66 21.51 6.55 39.16
51 INT20372 Localization of Il5 26 0.41 18.33 4.27 39.16
52 INT201474 Regulation of Acta1 3 0.18 1.98 0 37.80
53 INT266875 Positive_regulation of Narfl 37 0.05 38.43 3.73 36.52
54 INT21987 Positive_regulation of Rorb 30 0.33 12.7 12.24 29.92
55 INT184241 Regulation of Localization of Il4 4 0.15 3.89 1.58 28.24
56 INT184239 Regulation of Localization of Il13 2 0.14 3.24 1.2 28.24
57 INT347536 Regulation of Localization of Il5 1 0.22 1.44 0.42 28.24
58 INT20379 Localization of Il4 85 0.73 51.22 20.55 27.56
59 INT273763 Gene_expression of PSMB5 1 0.65 0.36 0.06 27.16
60 INT5843 Positive_regulation of Gfap 184 0.70 108.2 70.21 26.76
61 INT20382 Gene_expression of Hand2 211 0.66 142.26 51.05 26.76
62 INT5839 Positive_regulation of Transcription of Gfap 10 0.49 11.61 6.74 26.76
63 INT11325 Gene_expression of HLA-E 209 0.76 98.05 33.72 26.52
64 INT5840 Transcription of Gfap 26 0.71 18.18 10.41 26.36
65 INT20374 Gene_expression of Il4 515 0.76 306.15 114.12 26.24
66 INT100939 Gene_expression of Il13 176 0.73 125.1 43.38 26.24
67 INT20380 Gene_expression of Il5 172 0.78 104.75 34.78 26.24
68 INT170025 Gene_expression of Fig4 588 0.67 183.27 113.32 25.68
69 INT211264 Gene_expression of Hk2 7 0.56 12.12 0.46 25.28
70 INT285014 Gene_expression of Bnip3 4 0.61 10.38 0.29 23.84
71 INT97374 Gene_expression of Egln3 2 0.75 10.27 0.75 23.28
72 INT86024 Gene_expression of PPARA 736 0.78 497.93 91.14 22.60
73 INT104493 Negative_regulation of Mapk8 56 0.53 27.76 16.86 19.88
74 INT159750 Negative_regulation of Gene_expression of Mapk14 15 0.40 10.88 7.81 19.20
75 INT99070 Gene_expression of Mapk14 147 0.78 103.99 79.59 18.76
76 INT128695 Regulation of Gene_expression of Mapk14 14 0.44 11.49 7.14 18.76
77 INT48693 Regulation of VEGFA 268 0.62 191.88 31.52 15.84
78 INT24225 Gene_expression of Alms1 93 0.62 52.75 16.93 11.52
79 INT95734 Phosphorylation of Mapk8 108 0.82 49.92 33.52 9.68
80 INT59165 Binding of fc 67 0.36 37.51 8.68 9.36
81 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
82 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
83 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 5.00
84 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
85 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 5.00
86 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 5.00
87 INT2391 Negative_regulation of PTGS1 501 0.59 207.62 205.6 5.00
88 INT94952 Positive_regulation of Mapk14 305 0.70 197.83 186.61 5.00
89 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 5.00
90 INT66280 Gene_expression of Nos2 534 0.78 330.78 157.07 5.00
91 INT49134 Gene_expression of Grin1 270 0.78 84.78 148.61 5.00
92 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 5.00
93 INT48953 Positive_regulation of Nos2 486 0.70 239.85 131.87 5.00
94 INT5842 Gene_expression of Gfap 372 0.78 153.71 127.71 5.00
95 INT85640 Gene_expression of Tg(CAG-EGFP)D4Nagy 1138 0.72 311.58 119.18 5.00
96 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 5.00
97 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61 5.00
98 INT7341 Positive_regulation of Grin1 169 0.70 65.86 118.38 5.00
99 INT12339 Localization of IL8 437 0.81 251.87 117.39 5.00
100 INT11051 Positive_regulation of Gene_expression of IL6 415 0.69 319.21 109.3 5.00
101 INT47243 Gene_expression of Prkcg 195 0.78 58.05 108.44 5.00
102 INT12082 Localization of IL6 365 0.81 241.78 105.78 5.00
103 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 5.00
104 INT97701 Phosphorylation of Mapk14 191 0.82 115.33 100.46 5.00
105 INT92434 Phosphorylation of Mapk1 287 0.82 91.65 83.46 5.00
106 INT56291 Gene_expression of Ros1 503 0.63 274.12 81.5 5.00
107 INT79506 Gene_expression of Grin2b 122 0.78 43.71 73.42 5.00
108 INT9236 Regulation of Gene_expression of TNF 204 0.62 162.66 72.99 5.00
109 INT102546 Gene_expression of Ccl2 197 0.78 192.8 67.41 5.00
110 INT67614 Positive_regulation of PPARA 438 0.68 293.28 63.61 5.00
111 INT9657 Positive_regulation of Gene_expression of Il6 237 0.70 180.45 63.6 5.00
112 INT1951 Positive_regulation of Tlr4 345 0.70 176.99 62.42 5.00
113 INT11318 Gene_expression of Gtf3a 274 0.52 183.82 60.89 5.00
114 INT48901 Negative_regulation of IL6 186 0.57 136.33 57.87 5.00
115 INT73048 Gene_expression of MMP9 268 0.77 159.75 57.81 5.00
116 INT96937 Gene_expression of Mmp9 191 0.75 150.3 56.01 5.00
117 INT9234 Negative_regulation of Gene_expression of IL6 171 0.59 101.61 53.15 5.00
118 INT62543 Gene_expression of Icam1 231 0.78 187.58 52.71 5.00
119 INT72182 Gene_expression of Mcpt1 167 0.75 123.7 52.15 5.00
120 INT51627 Gene_expression of Grin2a 82 0.76 25.09 47.6 5.00
121 INT57021 Positive_regulation of Gene_expression of Grin1 62 0.70 24.77 47.31 5.00
122 INT6864 Positive_regulation of Gene_expression of Gfap 110 0.70 59.01 47.07 5.00
123 INT26500 Gene_expression of MMP2 201 0.78 110.57 46.9 5.00
124 INT114751 Gene_expression of Mapk1 137 0.76 60.14 39.98 5.00
125 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 5.00
126 INT82054 Positive_regulation of Grin2b 56 0.70 17.45 37.14 5.00
127 INT11246 Binding of Grin1 65 0.48 14.53 36.93 5.00
128 INT84260 Positive_regulation of Mapk8 124 0.69 72.84 35.98 5.00
129 INT70437 Negative_regulation of Mdk 115 0.57 41.03 35.72 5.00
130 INT103094 Binding of PPARA 308 0.47 177.26 34.75 5.00
131 INT104392 Gene_expression of Cxcl10 113 0.75 106.86 34.12 5.00
132 INT81289 Positive_regulation of Gene_expression of Tlr4 192 0.69 104.5 33.89 5.00
133 INT9658 Negative_regulation of Gene_expression of Il6 110 0.59 66.29 32.58 5.00
134 INT96913 Positive_regulation of Mapk8 179 0.69 130.44 32.2 5.00
135 INT92837 Negative_regulation of Gene_expression of Nos2 116 0.59 59.67 31.82 5.00
136 INT13186 Positive_regulation of Il4 113 0.68 71.22 31.4 5.00
137 INT65960 Gene_expression of BCL2 352 0.78 312.03 30.73 5.00
138 INT5117 Negative_regulation of Gene_expression of IL2 118 0.59 52.33 29.96 5.00
139 INT32165 Binding of CALM1 92 0.48 24.19 29.57 5.00
140 INT50230 Positive_regulation of Localization of IL6 105 0.70 69.21 29.52 5.00
141 INT86437 Binding of IL6 154 0.48 121.22 29.3 5.00
142 INT66200 Gene_expression of Gfap 215 0.78 88.04 28.25 5.00
143 INT11361 Gene_expression of SERPINE1 183 0.78 136.45 27.97 5.00
144 INT145426 Positive_regulation of Ros1 185 0.56 106.76 27.21 5.00
145 INT79395 Gene_expression of Twist1 193 0.77 100.06 26.34 5.00
146 INT130176 Positive_regulation of Gene_expression of CRP 125 0.66 137.06 25.9 5.00
147 INT122570 Negative_regulation of Akt1 173 0.59 91.44 25.53 5.00
148 INT130186 Gene_expression of Ccl5 101 0.74 79.96 25.01 5.00
149 INT106272 Positive_regulation of Positive_regulation of Mapk14 39 0.70 32.08 24.71 5.00
150 INT99069 Positive_regulation of Gene_expression of Mapk14 42 0.53 29.84 23.16 5.00
151 INT35711 Positive_regulation of Sdcbp 110 0.60 50.45 22.11 5.00
152 INT101517 Negative_regulation of PPARA 168 0.57 112.24 21.41 5.00
153 INT7535 Negative_regulation of Tlr4 111 0.56 56.84 21.37 5.00
154 INT99068 Gene_expression of Mapk8 62 0.78 33.57 21.25 5.00
155 INT89396 Phosphorylation of AKT1 225 0.82 111.66 19.61 5.00
156 INT101188 Gene_expression of Rela 81 0.56 23.43 19.15 5.00
157 INT2006 Gene_expression of fc 104 0.34 64.91 19.08 5.00
158 INT51054 Negative_regulation of Localization of IL6 45 0.59 24.48 18.97 5.00
159 INT90612 Positive_regulation of Grin2a 33 0.65 15.11 18.84 5.00
160 INT50420 Transcription of Grin1 30 0.71 13.21 18.28 5.00
161 INT61626 Transcription of IL6 73 0.72 42.04 17.86 5.00
162 INT9656 Regulation of Gene_expression of Il6 57 0.62 33.3 17.71 5.00
163 INT16624 Localization of Grin1 38 0.79 8.46 17.15 5.00
164 INT65659 Positive_regulation of STAT3 132 0.70 69.56 15.95 5.00
165 INT50618 Gene_expression of Dio1 48 0.74 17.37 15.91 5.00
166 INT85639 Positive_regulation of Tg(CAG-EGFP)D4Nagy 95 0.43 24.83 15.69 5.00
167 INT111462 Negative_regulation of Phosphorylation of Mapk1 45 0.57 19.49 15.59 5.00
168 INT79227 Negative_regulation of Gene_expression of Icam1 45 0.59 41.65 14.97 5.00
169 INT114510 Positive_regulation of Gria2 36 0.57 14.91 14.85 5.00
170 INT1888 Protein_catabolism of F13A1 97 0.99 63.48 14.82 5.00
171 INT109031 Positive_regulation of Eif2ak3 44 0.69 21.11 14.72 5.00
172 INT105387 Gene_expression of HIF1A 116 0.77 98.62 14.66 5.00
173 INT2843 Gene_expression of Epo 100 0.78 62.01 14.66 5.00
174 INT103096 Regulation of PPARA 113 0.60 62.47 14.57 5.00
175 INT100139 Positive_regulation of Gene_expression of PPARA 160 0.63 97.78 14.53 5.00
176 INT20420 Gene_expression of MYC 99 0.75 49.32 14.36 5.00
177 INT72127 Protein_catabolism of MMRN1 68 0.52 56 14.13 5.00
178 INT36177 Binding of Alms1 70 0.31 35.47 13.81 5.00
179 INT18773 Localization of ALB 117 0.80 69.18 13.8 5.00
180 INT104954 Negative_regulation of Positive_regulation of Mapk14 29 0.58 17.71 13.31 5.00
181 INT144646 Positive_regulation of Rela 53 0.67 27.78 13.2 5.00
182 INT17539 Positive_regulation of Igf1 68 0.69 28.47 13.02 5.00
183 INT50227 Positive_regulation of Adora2a 32 0.50 5.17 12.75 5.00
184 INT27268 Localization of Gtf3a 71 0.21 56.93 12.51 5.00
185 INT35801 Regulation of Alms1 34 0.38 20.88 12.38 5.00
186 INT150676 Positive_regulation of Gene_expression of Mapk1 30 0.45 10.06 12.37 5.00
187 INT27507 Positive_regulation of Dio1 23 0.44 3.43 12.11 5.00
188 INT109315 Gene_expression of Mapk8 70 0.78 45.46 11.65 5.00
189 INT118906 Regulation of Mapk14 21 0.44 17.95 11.63 5.00
190 INT96915 Phosphorylation of Mapk8 73 0.81 40.69 11.44 5.00
191 INT10874 Negative_regulation of Twist1 89 0.50 36.84 11.32 5.00
192 INT6748 Regulation of Dio1 15 0.45 2.63 11.18 5.00
193 INT121796 Gene_expression of NeuN 92 0.78 23.18 10.53 5.00
194 INT100379 Positive_regulation of HIF1A 69 0.69 57.31 10.4 5.00
195 INT173159 Localization of PPARA 96 0.74 64.55 10.26 5.00
196 INT126031 Negative_regulation of Gene_expression of MMP9 40 0.57 22.71 9.79 5.00
197 INT122584 Negative_regulation of Gene_expression of PPARA 56 0.58 37.61 9.76 5.00
198 INT70134 Negative_regulation of TXK 124 0.23 81.96 9.59 5.00
199 INT97439 Positive_regulation of Il5 46 0.60 25.6 9.47 5.00
200 INT24328 Gene_expression of Egf 97 0.75 59.65 9.42 5.00
Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox