D:Retrograde Degeneration

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Disease Term
Synonyms Axon Reaction, AXON REACTIONS, Axonal Reaction, AXONAL REACTIONS, Degeneration Nissl, Degeneration Retrograde, Degeneration Trans Synaptic, DEGENERATION TRANSNEURONAL RETROGRADE, Degenerations Retrograde, DEGENERATIONS TRANS SYNAPTIC, Degenerations Transneuronal Retrograde
Documents 24
Hot Single Events 15
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Retrograde Degeneration. They are ordered first by their relevance to Retrograde Degeneration and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT145940 Binding of Gad1 and Abat 2 0.14 1.44 1.78 5.00
2 INT338447 GAD1 Negative_regulation of Slc32a1 1 0.04 0.59 0.47 5.00
3 INT338443 Binding of Gad1 and Slc32a1 1 0.31 0.64 0.18 5.00
4 INT208458 TWIST1 Positive_regulation of Localization of Bdnf 1 0.01 0.19 0.15 5.00
5 INT208459 Galns Negative_regulation of Negative_regulation of BCAN 1 0.01 0.44 0.13 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Retrograde Degeneration. They are ordered first by their pain relevance and then by number of times they were reported in Retrograde Degeneration. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT2211 Negative_regulation of Abat 267 0.59 66.51 200.98 99.44
2 INT203473 Gene_expression of Pou4f1 69 0.76 25.94 11.36 94.48
3 INT1200 Negative_regulation of Ins1 274 0.58 155.17 56.14 93.48
4 INT164115 Gene_expression of 1190002H23Rik 11 0.58 5.18 1.17 92.72
5 INT81734 Regulation of Gene_expression of Arc 12 0.43 7.77 3.06 90.12
6 INT119940 Positive_regulation of Gene_expression of Arc 36 0.70 18.87 7.85 89.28
7 INT15756 Positive_regulation of Gene_expression of Jun 29 0.69 16.58 12.06 89.28
8 INT73314 Gene_expression of Arc 133 0.78 67.78 27.44 88.96
9 INT666 Gene_expression of Jun 124 0.78 54.61 33.67 88.96
10 INT728 Positive_regulation of Penk 1068 0.70 186.9 636.87 86.08
11 INT2421 Positive_regulation of Positive_regulation of Penk 97 0.69 13.38 55.32 86.08
12 INT7287 Positive_regulation of Transcription of Penk 103 0.70 19.81 50.37 86.08
13 INT4803 Transcription of Penk 435 0.72 59.09 182.4 84.24
14 INT477 Localization of Avp 813 0.81 131.58 300.4 81.92
15 INT4358 Positive_regulation of Localization of Avp 195 0.70 30.79 77.58 81.92
16 INT2451 Positive_regulation of Avp 355 0.70 102.66 147.69 77.92
17 INT8101 Binding of INCENP 42 0.31 16.2 6.68 77.68
18 INT1124 Negative_regulation of CD40LG 53 0.57 36.26 7 75.84
19 INT1127 Negative_regulation of IGHG3 32 0.28 21.1 7.37 75.12
20 INT1126 Negative_regulation of CD79A 46 0.59 31.07 6 74.72
21 INT41610 Positive_regulation of IGHD@ 2 0.42 1.5 0.23 71.76
22 INT5940 Negative_regulation of Avp 236 0.59 67.86 101.2 71.68
23 INT1616 Regulation of Gad1 46 0.61 10.2 28.64 65.84
24 INT164116 Negative_regulation of 1190002H23Rik 33 0.51 18.73 2.71 64.04
25 INT164117 Positive_regulation of Negative_regulation of 1190002H23Rik 3 0.40 2.16 0.27 64.04
26 INT11141 Negative_regulation of Gene_expression of Avp 23 0.59 3.85 12.19 60.40
27 INT266020 Positive_regulation of GM2AP1 1 0.32 0.39 0.17 59.84
28 INT1273 Gene_expression of Avp 356 0.78 90.56 138.7 59.52
29 INT338445 Positive_regulation of parkinsonism 1 0.01 3.26 0.47 56.52
30 INT266875 Positive_regulation of Narfl 37 0.05 38.43 3.73 53.00
31 INT22548 Positive_regulation of Casp3 483 0.70 258.78 213.07 51.52
32 INT271867 Binding of Bud31 1 0.07 0.6 0.03 51.44
33 INT289494 Regulation of 1190002H23Rik 1 0.04 1.64 0 48.76
34 INT5573 Negative_regulation of Gene_expression of Penk 113 0.59 21.83 64.66 43.92
35 INT796 Gene_expression of Penk 1902 0.78 275.47 1057.59 41.60
36 INT289497 Binding of Narfl 1 0.03 2.23 0 34.12
37 INT16259 Positive_regulation of Bdnf 336 0.70 183.48 209.82 32.76
38 INT69203 Positive_regulation of Ntf3 43 0.66 19.16 16.49 32.40
39 INT6822 Gene_expression of Pdyn 215 0.78 35.99 125.76 30.32
40 INT480 Negative_regulation of Localization of Avp 151 0.59 27.64 63.72 30.04
41 INT208455 Protein_catabolism of Ntf3 1 0.23 0.75 0.06 21.12
42 INT208456 Positive_regulation of Protein_catabolism of Ntf3 1 0.16 0.75 0.06 21.12
43 INT71689 Localization of Ntf3 23 0.73 11.1 7.91 19.68
44 INT9987 Gene_expression of Abat 296 0.78 95.46 226.34 18.40
45 INT7470 Positive_regulation of Gene_expression of Avp 37 0.70 19.55 19.96 14.96
46 INT185649 Regulation of ERG 17 0.20 10.14 1.49 8.72
47 INT289500 Negative_regulation of Regulation of ERG 1 0.02 0.92 0 8.72
48 INT7114 Positive_regulation of Ltp 1192 0.62 290.76 755.77 5.00
49 INT3439 Localization of Abat 1017 0.78 112.39 727.06 5.00
50 INT292 Localization of Penk 876 0.81 88.44 669.14 5.00
51 INT16260 Gene_expression of Bdnf 671 0.78 283.44 339.1 5.00
52 INT9158 Gene_expression of Tnf 722 0.78 522.01 277.68 5.00
53 INT2909 Positive_regulation of Abat 334 0.70 62.1 256.43 5.00
54 INT798 Positive_regulation of Gene_expression of Penk 394 0.70 78.53 203.07 5.00
55 INT3440 Negative_regulation of Localization of Abat 221 0.57 33.94 180.36 5.00
56 INT7506 Negative_regulation of Ltp 267 0.46 91.01 176.8 5.00
57 INT49134 Gene_expression of Grin1 270 0.78 84.78 148.61 5.00
58 INT7628 Gene_expression of Ltp 273 0.77 70.21 147.87 5.00
59 INT14151 Gene_expression of Casp3 311 0.78 140.26 120.68 5.00
60 INT7341 Positive_regulation of Grin1 169 0.70 65.86 118.38 5.00
61 INT4207 Regulation of Avp 267 0.62 63.72 115.33 5.00
62 INT16253 Positive_regulation of Gene_expression of Bdnf 196 0.70 92.67 113.01 5.00
63 INT7627 Negative_regulation of Positive_regulation of Ltp 162 0.50 41.2 106.27 5.00
64 INT74058 Gene_expression of Nos1 260 0.78 80.04 95.71 5.00
65 INT67682 Localization of Bdnf 204 0.81 72.36 88.92 5.00
66 INT13036 Positive_regulation of Positive_regulation of Ltp 105 0.51 23.71 77.66 5.00
67 INT7028 Localization of Pdyn 90 0.81 8.89 73.54 5.00
68 INT79506 Gene_expression of Grin2b 122 0.78 43.71 73.42 5.00
69 INT3034 Localization of Ngf 126 0.81 50.81 72.84 5.00
70 INT1080 Negative_regulation of Ache 343 0.59 108.51 72.4 5.00
71 INT13276 Regulation of Ltp 107 0.53 30.78 69.13 5.00
72 INT47690 Regulation of Bdnf 118 0.62 53.02 64.5 5.00
73 INT16258 Gene_expression of Ntf3 121 0.78 53.93 59.03 5.00
74 INT3920 Localization of Ldha 241 0.81 83.08 58.72 5.00
75 INT96533 Gene_expression of Slc1a3 72 0.78 26.85 55.31 5.00
76 INT119528 Positive_regulation of Camk2a 135 0.70 26.13 54.7 5.00
77 INT4957 Negative_regulation of Grin1 87 0.59 24.51 53.21 5.00
78 INT22546 Positive_regulation of Gene_expression of Casp3 97 0.70 47.89 51.92 5.00
79 INT51627 Gene_expression of Grin2a 82 0.76 25.09 47.6 5.00
80 INT374 Positive_regulation of Ldha 212 0.70 107.08 47.43 5.00
81 INT42980 Gene_expression of GAD1 139 0.69 94.77 45.11 5.00
82 INT47683 Negative_regulation of Bdnf 92 0.59 47.53 43.55 5.00
83 INT26788 Gene_expression of Gad1 93 0.78 27.05 42.71 5.00
84 INT27798 Gene_expression of Ntrk2 111 0.78 56.08 42.68 5.00
85 INT16261 Transcription of Bdnf 101 0.72 49.41 40.64 5.00
86 INT12228 Positive_regulation of Gene_expression of Abat 44 0.65 17.51 40.55 5.00
87 INT82054 Positive_regulation of Grin2b 56 0.70 17.45 37.14 5.00
88 INT101992 Localization of VEGFA 413 0.81 258.23 36.15 5.00
89 INT894 Binding of Avp 84 0.48 29.16 29.63 5.00
90 INT80470 Negative_regulation of Gene_expression of Grin1 33 0.59 10.22 27.15 5.00
91 INT32826 Positive_regulation of Gene_expression of Ltp 52 0.45 10.34 26.8 5.00
92 INT63444 Regulation of Gene_expression of Abat 26 0.51 14.65 26.29 5.00
93 INT276 Regulation of Ache 83 0.62 16.75 25.99 5.00
94 INT93485 Negative_regulation of Slc1a2 27 0.59 10.65 20.9 5.00
95 INT48144 Gene_expression of Fgf2 117 0.78 43 20.48 5.00
96 INT16326 Transcription of Gad1 58 0.71 15.78 20.45 5.00
97 INT31874 Negative_regulation of Gene_expression of Abat 31 0.42 12.22 20.31 5.00
98 INT107930 Gene_expression of Slc17a7 39 0.78 6.53 18.86 5.00
99 INT90612 Positive_regulation of Grin2a 33 0.65 15.11 18.84 5.00
100 INT4340 Positive_regulation of Localization of Ldha 46 0.70 14.52 15.66 5.00
101 INT11945 Regulation of Chat 38 0.62 7.75 14.97 5.00
102 INT74098 Negative_regulation of Gene_expression of Nos1 36 0.59 16.25 14.82 5.00
103 INT4736 Gene_expression of Chat 67 0.77 17.15 14.24 5.00
104 INT7342 Positive_regulation of Positive_regulation of Grin1 18 0.50 9.22 13.76 5.00
105 INT75224 Positive_regulation of Gene_expression of Ntf3 23 0.69 11.79 13.08 5.00
106 INT12191 Negative_regulation of Localization of Ldha 35 0.59 13.71 12.35 5.00
107 INT16255 Negative_regulation of Ntf3 21 0.51 12.92 11.93 5.00
108 INT56048 Positive_regulation of Transcription of Bdnf 24 0.70 8.33 11.83 5.00
109 INT4047 Binding of F13A1 105 0.43 66.54 11.81 5.00
110 INT54466 Negative_regulation of Gene_expression of Ltp 19 0.38 5.44 10.91 5.00
111 INT9027 Positive_regulation of Ddc 24 0.66 6.04 10.19 5.00
112 INT10139 Positive_regulation of F13A1 64 0.56 44.75 9.69 5.00
113 INT336 Negative_regulation of Gad1 19 0.58 7.71 9.51 5.00
114 INT72789 Gene_expression of Cpa1 29 0.50 12.36 9.47 5.00
115 INT68133 Localization of Fgf2 36 0.81 15.37 9.14 5.00
116 INT7090 Gene_expression of pcp 50 0.66 13.54 8.96 5.00
117 INT63739 Regulation of Gad2 15 0.58 3.44 8.86 5.00
118 INT6499 Localization of Ntrk2 44 0.79 11.78 8.75 5.00
119 INT15723 Gene_expression of Fn1 47 0.78 37.59 8.51 5.00
120 INT119525 Negative_regulation of Positive_regulation of Camk2a 14 0.43 5.15 8.45 5.00
121 INT84894 Gene_expression of Calb2 45 0.73 24.65 7.81 5.00
122 INT98178 Localization of Casp3 32 0.65 21.01 7.77 5.00
123 INT132468 Positive_regulation of Positive_regulation of Camk2a 20 0.70 2.76 6.7 5.00
124 INT57256 Gene_expression of HLA-DQA2 52 0.55 23.87 6.27 5.00
125 INT116641 Phosphorylation of Gsk3a 12 0.71 4.3 6.22 5.00
126 INT99506 Negative_regulation of Bcl2l1 25 0.58 15.7 6.09 5.00
127 INT105215 Negative_regulation of Pou4f1 16 0.53 9.42 5.97 5.00
128 INT30195 Gene_expression of Ubqln1 12 0.10 1.09 5.89 5.00
129 INT139749 Regulation of Ubqln1 10 0.02 2.47 5.38 5.00
130 INT37652 Positive_regulation of Pgr 29 0.59 9.09 4.67 5.00
131 INT119785 Localization of GAD1 7 0.63 5.99 4.34 5.00
132 INT116622 Positive_regulation of Nefh 17 0.39 11.98 3.86 5.00
133 INT115890 Gene_expression of Nefh 28 0.68 11.55 3.84 5.00
134 INT48143 Gene_expression of Fgf1 32 0.78 8.2 3.72 5.00
135 INT154867 Gene_expression of CECR 28 0.57 6.97 3.72 5.00
136 INT34822 Regulation of Localization of Ldha 12 0.57 4.03 3.65 5.00
137 INT196779 Phosphorylation of Ppp2ca 28 0.72 1.86 3.25 5.00
138 INT85542 Negative_regulation of Calb2 5 0.38 5.4 3.18 5.00
139 INT90611 Positive_regulation of Positive_regulation of Grin2a 4 0.63 1.89 3 5.00
140 INT88852 Protein_catabolism of Casp3 28 0.65 23.57 2.74 5.00
141 INT125272 Gene_expression of Slc32a1 11 0.65 0.47 2.64 5.00
142 INT21516 Negative_regulation of Positive_regulation of Ldha 13 0.43 4.73 2.53 5.00
143 INT131112 Phosphorylation of Casp3 7 0.63 4.1 2.46 5.00
144 INT74046 Localization of Calb2 12 0.80 2.05 2.24 5.00
145 INT35380 Binding of Fn1 8 0.35 4.84 2.23 5.00
146 INT143591 Binding of NeuN 10 0.31 2.23 2.22 5.00
147 INT98176 Positive_regulation of Localization of Casp3 7 0.33 6.85 2.12 5.00
148 INT129505 Regulation of Slc17a7 5 0.37 1.09 2.11 5.00
149 INT90272 Gene_expression of Ppp2ca 18 0.68 4.69 2.08 5.00
150 INT79983 Negative_regulation of Gene_expression of GAD1 7 0.41 4.02 1.9 5.00
151 INT128269 Positive_regulation of Slc17a7 3 0.50 1.06 1.82 5.00
152 INT128273 Regulation of Gene_expression of Slc17a7 3 0.62 0.82 1.72 5.00
153 INT12442 Localization of Vegfa 11 0.73 4.85 1.68 5.00
154 INT261849 Positive_regulation of Phosphorylation of Gsk3a 3 0.14 1.15 1.57 5.00
155 INT62979 Positive_regulation of ERG 11 0.25 4.5 1.48 5.00
156 INT189302 Positive_regulation of Gene_expression of HLA-DQA2 6 0.06 4.44 1.48 5.00
157 INT36148 Binding of GAD1 10 0.41 7.91 1.47 5.00
158 INT116625 Phosphorylation of Nefh 13 0.79 5.94 1.4 5.00
159 INT135746 Gene_expression of Ascl1 4 0.65 0.21 1.27 5.00
160 INT209417 Gene_expression of ERG 21 0.20 6.69 1.26 5.00
161 INT209336 Gene_expression of Filipino 5 0.10 4.75 1.2 5.00
162 INT57188 Regulation of Gene_expression of Chat 4 0.45 1.89 1.12 5.00
163 INT177492 Positive_regulation of Slc32a1 3 0.45 1.25 1.09 5.00
164 INT203489 Positive_regulation of Gene_expression of Pou4f1 3 0.49 2.33 0.84 5.00
165 INT120603 Negative_regulation of Cntf 6 0.35 3.57 0.78 5.00
166 INT28869 Regulation of Ear11 3 0.18 1.62 0.75 5.00
167 INT196753 Negative_regulation of Phosphorylation of Ppp2ca 3 0.37 0.52 0.7 5.00
168 INT320583 Negative_regulation of Slc32a1 2 0.35 0.93 0.64 5.00
169 INT196765 Positive_regulation of Gene_expression of Ppp2ca 4 0.44 1.05 0.6 5.00
170 INT261850 Regulation of Positive_regulation of Slc17a7 1 0.10 0.49 0.58 5.00
171 INT190479 Positive_regulation of 1190002H23Rik 6 0.07 5.64 0.53 5.00
172 INT95161 Localization of Ncam1 5 0.80 1.01 0.45 5.00
173 INT309361 Negative_regulation of Gene_expression of Slc32a1 2 0.48 0.22 0.39 5.00
174 INT312566 Positive_regulation of Gene_expression of CECR 1 0.19 1.67 0.38 5.00
175 INT289498 Negative_regulation of Narfl 4 0.03 3.05 0.31 5.00
176 INT309363 Regulation of Slc32a1 2 0.37 0.37 0.3 5.00
177 INT289496 Gene_expression of Narfl 3 0.05 3.43 0.25 5.00
178 INT338444 Binding of parkinsonism 1 0.00 1.43 0.25 5.00
179 INT266021 Positive_regulation of Localization of GM2AP1 1 0.37 0.68 0.19 5.00
180 INT260959 Gene_expression of G8 8 0.32 2.74 0.18 5.00
181 INT271866 Positive_regulation of Gene_expression of G8 1 0.20 0.21 0.16 5.00
182 INT190974 Regulation of Gene_expression of Calb2 2 0.29 0.36 0.16 5.00
183 INT208454 Localization of Rpl4 2 0.52 0.35 0.14 5.00
184 INT208450 Negative_regulation of BCAN 1 0.03 0.43 0.12 5.00
185 INT266019 Localization of GM2AP1 1 0.55 0.34 0.09 5.00
186 INT338446 Binding of Slc32a1 1 0.31 0.16 0.08 5.00
187 INT289490 Negative_regulation of Negative_regulation of Pou4f1 1 0.32 0.09 0.06 5.00
188 INT284544 Gene_expression of Sars 3 0.22 1.53 0.03 5.00
189 INT289493 Regulation of Narfl 1 0.03 1.61 0 5.00
190 INT271858 Gene_expression of Av1 1 0.65 0.07 0 5.00
191 INT237443 Positive_regulation of Phosphorylation of Casp3 1 0.39 0.09 0 5.00
192 INT289492 Localization of Narfl 1 0.05 2.38 0 5.00
193 INT289499 Positive_regulation of Sars 2 0.15 0.56 0 5.00
194 INT289491 Transcription of Thy1 1 0.26 1.05 0 5.00
195 INT271868 Gene_expression of Bud31 1 0.14 0.33 0 5.00
196 INT289495 Regulation of Positive_regulation of Narfl 1 0.04 0.59 0 5.00
197 INT256397 Binding of Nefh 3 0.09 1.31 0 5.00
198 INT289501 Binding of ERG 1 0.02 0.05 0 5.00
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