D:Retts Disease

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Disease Term
Synonyms Autism Dementia Ataxia Loss Of Purposeful Hand Use Syndrome, Cerebroatrophic Hyperammonemia, CEREBROATROPHIC HYPERAMMONEMIAS, Hyperammonemia Cerebroatrophic, Hyperammonemias Cerebroatrophic, Rett Disease, RETT DISORDER, RETT S DISEASES, Rett S Disorder, Rett S Syndrome, Rett Syndrome
Documents 53
Hot Single Events 53
Hot Interactions 2

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Retts Disease. They are ordered first by their relevance to Retts Disease and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT135360 Binding of Mecp2 and Aadac 1 0.03 0.19 0.51 94.72
2 INT318969 Mecp2 Regulation of Gene_expression of Bdnf 1 0.17 0.28 0.17 86.64
3 INT135364 Prr14 Positive_regulation of Mbd1 1 0.22 0.15 0.64 76.24
4 INT135363 Mecp2 Positive_regulation of Mbd1 1 0.50 0.15 0.64 76.24
5 INT135361 Prr14 Positive_regulation of Mecp2 1 0.24 0.15 0.64 75.48
6 INT320953 Binding of Bdywt and Tapr 1 0.03 0.54 0 74.44
7 INT247265 Mecp2 Regulation of Fos 1 0.25 0.38 0.52 5.00
8 INT268279 Positive_regulation of Binding of Aggf1 and Alms1 1 0.02 0.15 0.18 5.00
9 INT268280 Binding of Aggf1 and Alms1 1 0.01 0.15 0.18 5.00
10 INT247266 Binding of Mecp2 and Fos 1 0.30 0.18 0.13 5.00
11 INT247267 Binding of Egr1 and Mecp2 1 0.12 0.18 0.13 5.00
12 INT328143 Gabrb3 Positive_regulation of Ube3a 1 0.56 0.99 0.11 5.00
13 INT328146 Gabrb3 Negative_regulation of Ube3a 1 0.48 0.99 0.11 5.00
14 INT288219 Cigs1 Regulation of Nrgn 1 0.00 0.87 0.1 5.00
15 INT174133 Binding of Igfals and Sod1 3 0.19 3 0.08 5.00
16 INT247264 Mecp2 Positive_regulation of Gtf2i 1 0.02 0 0.08 5.00
17 INT328150 H2-Q13 Positive_regulation of Gene_expression of Ube3a 1 0.55 1.23 0.07 5.00
18 INT328148 H2-Q13 Positive_regulation of Ube3a 1 0.55 1.23 0.07 5.00
19 INT328145 H2-Q13 Positive_regulation of Atp10a 1 0.54 1.23 0.07 5.00
20 INT328144 H2-Q13 Positive_regulation of Gene_expression of Atp10a 1 0.54 1.23 0.07 5.00
21 INT297850 Snx1 Positive_regulation of Protein_catabolism of P9Ehs1 1 0.01 0.31 0.05 5.00
22 INT352669 PRKDC Positive_regulation of Memor1 1 0.00 1.02 0.04 5.00
23 INT297848 Binding of Fzd4 and Ndp 1 0.04 1.19 0 5.00
24 INT297855 Binding of Ndp and Wnt1 1 0.38 1.18 0 5.00
25 INT328142 Binding of Atp10a and Snrpn 1 0.30 0.3 0 5.00
26 INT297854 Agrp Regulation of Pomc 1 0.24 0 0 5.00
27 INT297852 Nanos2 Positive_regulation of Positive_regulation of Gopc 1 0.07 0.1 0 5.00
28 INT297856 Pdk4 Positive_regulation of Positive_regulation of Gopc 1 0.07 0.1 0 5.00
29 INT328141 Binding of Chrne and Gabrb3 1 0.41 0.08 0 5.00
30 INT297851 Nanos2 Regulation of Stra8 1 0.35 0.6 0 5.00
31 INT297853 Nanos2 Positive_regulation of Positive_regulation of Snord116 1 0.49 0.1 0 5.00
32 INT297849 Pdk4 Positive_regulation of Positive_regulation of Snord116 1 0.50 0.1 0 5.00
33 INT297846 Nanos2 Regulation of Dnmt3l 1 0.34 0.6 0 5.00
34 INT317900 Binding of NCAPH2 and MCPH1 1 0.02 0.53 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Retts Disease. They are ordered first by their pain relevance and then by number of times they were reported in Retts Disease. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT159509 Positive_regulation of MECP2 3 0.42 1.8 0.31 100.00
2 INT320942 Localization of Tapr 2 0.10 1.72 0.28 99.88
3 INT318967 Gene_expression of Mecp2 9 0.77 11.52 3.55 99.64
4 INT102903 Regulation of Gene_expression of Bdnf 35 0.62 20.1 17.42 99.44
5 INT92669 Gene_expression of Bdnf 309 0.78 178.26 116.68 99.36
6 INT328132 Regulation of Mecp2 1 0.40 1 0 98.60
7 INT280467 Negative_regulation of Mecp2 5 0.59 3.33 1.21 98.52
8 INT796 Gene_expression of Penk 1902 0.78 275.47 1057.59 98.36
9 INT103882 Gene_expression of MECP2 17 0.76 10.47 0.96 97.64
10 INT104567 Gene_expression of Aqp1 47 0.78 44.84 28.68 97.40
11 INT5288 Gene_expression of EDDM3B 5 0.05 3.04 1.09 97.36
12 INT115039 Positive_regulation of FMR1 4 0.49 2.26 0.46 97.20
13 INT66331 Gene_expression of Cacna1a 101 0.78 49.58 46.32 96.64
14 INT320940 Gene_expression of Fxyd1 1 0.60 0.95 0.04 96.60
15 INT135355 Binding of Mecp2 4 0.37 0.83 1.72 96.44
16 INT135359 Positive_regulation of Mecp2 4 0.70 4.35 6.05 96.44
17 INT135356 Positive_regulation of Binding of Mecp2 1 0.50 0.1 0.36 96.44
18 INT294806 Gene_expression of Dlx5 6 0.71 2.07 0.3 96.20
19 INT193422 Negative_regulation of Tapr 2 0.06 1.52 0.11 95.96
20 INT135351 Positive_regulation of Mbd1 1 0.63 0.34 1.46 95.56
21 INT135354 Positive_regulation of Binding of Mbd1 1 0.39 0.1 0.36 95.56
22 INT135357 Binding of Mbd1 1 0.29 0.1 0.35 95.56
23 INT320952 Regulation of Gene_expression of Mecp2 1 0.45 0.87 0 95.20
24 INT7506 Negative_regulation of Ltp 267 0.46 91.01 176.8 94.72
25 INT13276 Regulation of Ltp 107 0.53 30.78 69.13 94.72
26 INT60145 Regulation of Negative_regulation of Ltp 4 0.23 1.82 4.09 94.72
27 INT109826 Negative_regulation of Regulation of Ltp 3 0.35 0.31 1.36 94.72
28 INT318963 Positive_regulation of Mecp2 5 0.50 1.78 1.49 94.16
29 INT38788 Negative_regulation of CYSLTR1 8 0.42 4.5 1.16 93.96
30 INT185964 Negative_regulation of Gene_expression of Syp 8 0.54 2.33 0.35 93.24
31 INT160853 Gene_expression of Syp 87 0.72 20.06 5.31 93.24
32 INT198744 Negative_regulation of Gene_expression of Dlg4 6 0.42 1.73 0.54 93.24
33 INT108643 Gene_expression of Dlg4 61 0.76 8.63 8.58 93.24
34 INT738 Regulation of POMC 459 0.62 111.19 243.74 92.52
35 INT11685 Regulation of CSF2 99 0.59 58.82 15.9 92.52
36 INT184479 Regulation of Tfrc 3 0.09 3.97 1.01 90.40
37 INT13501 Binding of Drd2 65 0.48 23.76 35.6 88.88
38 INT32432 Positive_regulation of Binding of Drd2 7 0.67 2.72 5.19 88.88
39 INT130385 Gene_expression of ERCC6 7 0.77 8.36 0.63 88.64
40 INT467 Gene_expression of POMC 1048 0.78 332.8 394.16 88.48
41 INT280463 Binding of Mecp2 3 0.37 4 0.63 88.12
42 INT11795 Negative_regulation of Helt 33 0.28 6.51 14.76 88.08
43 INT318962 Negative_regulation of Gene_expression of Mecp2 2 0.43 0.5 0.7 86.44
44 INT320943 Negative_regulation of Phosphorylation of Mecp2 1 0.43 0.33 0 86.44
45 INT144539 Phosphorylation of Mecp2 3 0.82 6.18 6.2 86.08
46 INT797 Regulation of Penk 812 0.62 111.13 542.24 85.36
47 INT243872 Negative_regulation of Gene_expression of DLGAP1 1 0.21 1.18 0.06 84.80
48 INT243878 Gene_expression of DLGAP1 1 0.38 1.17 0.06 84.80
49 INT104570 Localization of Aqp1 8 0.77 5.83 3.51 84.76
50 INT248208 Phosphorylation of Mecp2 3 0.82 1.17 0.26 84.64
51 INT185973 Negative_regulation of Syp 16 0.54 2.83 0.87 83.52
52 INT198749 Negative_regulation of Dlg4 8 0.53 2.14 0.54 82.80
53 INT320948 Negative_regulation of Stx1a 1 0.41 0.41 0.04 80.84
54 INT61873 Gene_expression of Arc 128 0.78 128.25 52.24 79.40
55 INT320946 Gene_expression of Syt9 1 0.52 0.18 0 79.40
56 INT67037 Gene_expression of Sod1 121 0.78 59.32 7.99 79.20
57 INT144542 Positive_regulation of Phosphorylation of Mecp2 2 0.68 1.43 1.5 79.04
58 INT320949 Negative_regulation of Binding of Mecp2 1 0.43 0.21 0 78.88
59 INT66040 Positive_regulation of Bdnf 114 0.69 67.67 51.81 77.72
60 INT243881 Negative_regulation of SHANK3 1 0.34 1.16 0.06 76.16
61 INT243863 Negative_regulation of Binding of SHANK3 1 0.34 1.16 0.06 76.16
62 INT243871 Binding of SHANK3 1 0.30 1.09 0.06 76.16
63 INT218 Positive_regulation of Th 245 0.70 40.5 120.1 75.00
64 INT217 Negative_regulation of Th 134 0.59 26.83 62.63 75.00
65 INT162 Regulation of Prl 794 0.62 165.01 322.24 75.00
66 INT19 Regulation of Gnrhr 131 0.62 36.4 55.66 75.00
67 INT243868 Binding of NLGN1 1 0.36 1.09 0.06 74.96
68 INT243874 Negative_regulation of Binding of NLGN1 1 0.41 1.16 0.06 74.96
69 INT243865 Negative_regulation of NLGN1 1 0.41 1.15 0.06 74.32
70 INT170054 Negative_regulation of Gopc 280 0.38 117.89 42.4 74.08
71 INT234494 Positive_regulation of Syp 12 0.65 2.47 0.69 73.36
72 INT243866 Negative_regulation of CYTIP 1 0.05 1.09 0.06 73.12
73 INT171715 Gene_expression of Sema5b 46 0.31 6.46 7.48 71.48
74 INT318964 Negative_regulation of Localization of Mecp2 1 0.43 0.53 0.43 70.72
75 INT183395 Localization of Mecp2 4 0.75 1.76 0.69 70.40
76 INT135350 Positive_regulation of Hdac2 2 0.43 0.63 1.03 70.08
77 INT135358 Positive_regulation of Transcription of Hdac2 1 0.43 0.15 0.67 70.08
78 INT135352 Transcription of Hdac2 2 0.59 0.94 0.75 69.72
79 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 69.04
80 INT12681 Regulation of Trib3 76 0.53 23.92 26.58 68.88
81 INT139236 Regulation of Sgk1 2 0.37 0.84 1.14 68.88
82 INT320950 Positive_regulation of Gene_expression of Mecp2 1 0.50 1.24 0 68.56
83 INT280468 Positive_regulation of Localization of Mecp2 3 0.50 1.76 0.45 68.32
84 INT16281 Negative_regulation of Anxty 20 0.48 17.23 4.06 66.96
85 INT135353 Negative_regulation of LOC680498 2 0.21 0.92 0.75 65.64
86 INT77619 Gene_expression of Prkaca 43 0.75 8.55 14.13 64.80
87 INT5587 Regulation of Fos 191 0.62 40.81 99.7 64.04
88 INT47704 Regulation of Egr1 17 0.60 2.43 5.18 64.04
89 INT115074 Positive_regulation of GRIA1 10 0.67 2.66 4.48 61.88
90 INT181282 Transcription of INCENP 10 0.11 1.21 0.66 60.20
91 INT320951 Negative_regulation of Gene_expression of Stx1a 1 0.40 0.56 0.11 58.32
92 INT234083 Gene_expression of Stx1a 10 0.64 1.41 0.41 57.80
93 INT29988 Gene_expression of Mecp2 27 0.78 5.45 9.47 55.52
94 INT6943 Positive_regulation of Gabrd 71 0.70 17.36 35.25 55.00
95 INT59665 Positive_regulation of Ugt1a6 24 0.69 7.24 13.25 55.00
96 INT7114 Positive_regulation of Ltp 1192 0.62 290.76 755.77 54.40
97 INT352662 Negative_regulation of Gene_expression of FMR1 1 0.31 1.05 0.03 54.36
98 INT34058 Gene_expression of FMR1 5 0.75 5.11 0.26 53.88
99 INT157186 Regulation of Cps1 4 0.22 0.54 0.67 51.68
100 INT1495 Positive_regulation of Rtcd1 91 0.54 22.93 32.43 49.68
101 INT65979 Regulation of SLC6A2 5 0.04 1.46 1.45 49.28
102 INT69222 Positive_regulation of Sod1 15 0.61 8.19 1.87 46.48
103 INT174127 Positive_regulation of Positive_regulation of Sod1 2 0.45 4.9 0.19 46.48
104 INT61116 Positive_regulation of Ppara 119 0.69 58.62 21.6 44.32
105 INT15898 Positive_regulation of Prkaca 199 0.70 50.89 87.54 41.68
106 INT63932 Positive_regulation of Ephb1 537 0.70 259.67 296.14 38.68
107 INT10534 Positive_regulation of Trib3 209 0.60 78.75 81.48 38.52
108 INT320939 Transcription of Mecp2 1 0.69 0.2 0 36.08
109 INT320947 Gene_expression of Ctrcts 1 0.16 0.12 0 32.28
110 INT5228 Positive_regulation of Fos 934 0.70 209.8 503.87 32.00
111 INT5862 Positive_regulation of Egr1 82 0.70 30.4 33.96 32.00
112 INT320944 Regulation of Tapr 2 0.06 0.6 0 31.84
113 INT170988 Positive_regulation of CYSLTR1 15 0.34 6.23 4.44 21.00
114 INT224975 Gene_expression of Ube3a 5 0.76 7.18 1.69 18.08
115 INT268278 Regulation of Binding of Aggf1 1 0.08 0.44 0.33 14.88
116 INT231154 Binding of Aggf1 2 0.07 2.18 0.84 13.44
117 INT243870 Negative_regulation of SLC6A9 1 0.42 0.45 0.37 5.48
118 INT5200 Gene_expression of Fos 3083 0.78 894.43 1639.02 5.00
119 INT5202 Positive_regulation of Gene_expression of Fos 1163 0.70 319.28 684 5.00
120 INT5591 Regulation of Gene_expression of Fos 425 0.62 129.06 265.78 5.00
121 INT16259 Positive_regulation of Bdnf 336 0.70 183.48 209.82 5.00
122 INT2640 Gene_expression of Pomc 424 0.78 120.72 155.37 5.00
123 INT7628 Gene_expression of Ltp 273 0.77 70.21 147.87 5.00
124 INT14843 Gene_expression of Gabrg1 301 0.77 62.63 139.16 5.00
125 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 5.00
126 INT203 Positive_regulation of Pomc 257 0.70 90.56 92.84 5.00
127 INT9516 Negative_regulation of Gabrg1 149 0.53 27.83 91.02 5.00
128 INT5590 Negative_regulation of Fos 144 0.59 40.94 81.98 5.00
129 INT56291 Gene_expression of Ros1 503 0.63 274.12 81.5 5.00
130 INT29708 Gene_expression of Gria1 177 0.78 56.36 77.37 5.00
131 INT17546 Negative_regulation of Ngf 135 0.59 60.28 77.19 5.00
132 INT24958 Gene_expression of Nkx1-1 106 0.74 51.29 76.88 5.00
133 INT79506 Gene_expression of Grin2b 122 0.78 43.71 73.42 5.00
134 INT14049 Positive_regulation of GRIN1 102 0.70 48.31 71.06 5.00
135 INT170332 Gene_expression of IFN1@ 477 0.75 275.21 69.65 5.00
136 INT5861 Gene_expression of Egr1 203 0.78 49.35 68.13 5.00
137 INT462 Regulation of Pomc 157 0.62 41.67 67.27 5.00
138 INT1430 Regulation of PDYN 88 0.60 16.99 60.32 5.00
139 INT1536 Negative_regulation of NA 244 0.55 52.67 59.79 5.00
140 INT169926 Positive_regulation of Gopc 416 0.46 157.8 58.67 5.00
141 INT6669 Negative_regulation of Positive_regulation of Fos 98 0.59 23.5 56.82 5.00
142 INT3213 Gene_expression of Ins1 511 0.76 357.59 53.32 5.00
143 INT51627 Gene_expression of Grin2a 82 0.76 25.09 47.6 5.00
144 INT26698 Positive_regulation of Cacna1a 37 0.67 26.33 39.1 5.00
145 INT173693 Localization of Gopc 249 0.65 70.49 38.81 5.00
146 INT163134 Gene_expression of ACR 78 0.65 30.39 38.48 5.00
147 INT14031 Gene_expression of Npy 107 0.78 36.48 35.4 5.00
148 INT47710 Negative_regulation of GRIN1 71 0.57 25.57 34.24 5.00
149 INT6053 Transcription of Fos 107 0.72 20.97 31.88 5.00
150 INT6277 Positive_regulation of Gene_expression of Pomc 76 0.70 21.45 31.09 5.00
151 INT106554 Positive_regulation of Gene_expression of Bdnf 73 0.70 42.58 30.77 5.00
152 INT34729 Positive_regulation of IFN1@ 233 0.67 128.04 30.38 5.00
153 INT67912 Gene_expression of GRIN1 75 0.77 28.99 29.28 5.00
154 INT145426 Positive_regulation of Ros1 185 0.56 106.76 27.21 5.00
155 INT56053 Negative_regulation of Bdnf 77 0.58 64.4 26.83 5.00
156 INT605 Regulation of Acot1 61 0.62 10.7 26.34 5.00
157 INT6054 Positive_regulation of Gene_expression of Egr1 67 0.70 18.45 25.93 5.00
158 INT7584 Gene_expression of Crh 112 0.78 39.15 25.33 5.00
159 INT41487 Negative_regulation of Cacna1a 16 0.57 9.42 25.2 5.00
160 INT101483 Gene_expression of Lep 159 0.78 104.77 25.12 5.00
161 INT57192 Binding of Ltp 43 0.41 17.48 24.96 5.00
162 INT5586 Binding of Fos 47 0.48 12.7 21.33 5.00
163 INT8075 Localization of Crh 64 0.81 25.41 19.45 5.00
164 INT33327 Positive_regulation of Gene_expression of Gabrg1 39 0.69 9.68 18.82 5.00
165 INT192409 Positive_regulation of Gene_expression of IFN1@ 102 0.67 64.66 18.8 5.00
166 INT106556 Negative_regulation of Gene_expression of Bdnf 42 0.59 34.71 17.64 5.00
167 INT31136 Binding of Cacna1a 28 0.45 30.76 17.35 5.00
168 INT170051 Positive_regulation of Gene_expression of Gopc 150 0.43 56.75 16.93 5.00
169 INT197375 Gene_expression of Car1 84 0.65 16.46 16.45 5.00
170 INT170335 Gene_expression of INCENP 176 0.54 91.62 15.31 5.00
171 INT6278 Negative_regulation of Gene_expression of Pomc 35 0.59 11.07 14.8 5.00
172 INT27266 Regulation of Gene_expression of Pomc 41 0.62 6.74 14.59 5.00
173 INT28314 Negative_regulation of Gene_expression of Gabrg1 29 0.44 12.56 13.8 5.00
174 INT21646 Positive_regulation of Npy 40 0.70 31.31 13.57 5.00
175 INT80685 Gene_expression of MAPK8 90 0.72 51.91 13.36 5.00
176 INT63104 Negative_regulation of CALCRL 29 0.37 13.62 12.42 5.00
177 INT6051 Positive_regulation of Transcription of Fos 27 0.69 6.3 11.48 5.00
178 INT5464 Regulation of CALCRL 24 0.16 4.2 11.19 5.00
179 INT75765 Positive_regulation of Gene_expression of Cacna1a 17 0.70 17.51 10.91 5.00
180 INT101481 Positive_regulation of Lep 81 0.69 62.59 9.95 5.00
181 INT5465 Positive_regulation of CALCRL 25 0.49 7.24 9.8 5.00
182 INT120509 Gene_expression of Cat 65 0.77 50.9 9.75 5.00
183 INT96637 Gene_expression of Gad2 21 0.76 8.15 9.53 5.00
184 INT21794 Positive_regulation of Gene_expression of Npy 20 0.70 8.44 9.3 5.00
185 INT189506 Gene_expression of Anxty 32 0.55 45.92 9.11 5.00
186 INT13467 Positive_regulation of ABCB1 36 0.68 9.68 8.95 5.00
187 INT89180 Gene_expression of Agrp 54 0.78 14.29 8.84 5.00
188 INT179753 Gene_expression of SLC1A2 28 0.59 13.72 8.71 5.00
189 INT21179 Negative_regulation of Crh 22 0.58 8.03 7.87 5.00
190 INT6057 Negative_regulation of Gene_expression of Egr1 17 0.57 4.17 7.17 5.00
191 INT147583 Gene_expression of AIS 82 0.58 48.7 7.11 5.00
192 INT173967 Gene_expression of Mri1 26 0.43 16.67 6.45 5.00
193 INT157932 Positive_regulation of ADHD1 46 0.48 52.18 6.13 5.00
194 INT15190 Regulation of Npy 17 0.61 5.33 5.84 5.00
195 INT245587 Regulation of Car1 13 0.27 4.68 5.72 5.00
196 INT101482 Negative_regulation of Lep 53 0.54 33.59 5.65 5.00
197 INT6276 Negative_regulation of Positive_regulation of Pomc 12 0.57 3.65 5.49 5.00
198 INT165460 Gene_expression of SLC1A3 15 0.75 7.19 5.43 5.00
199 INT91754 Gene_expression of Cp 42 0.77 21.97 5.38 5.00
200 INT147584 Localization of AIS 38 0.63 12.83 5.27 5.00
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