D:Rheumatic Diseases

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Disease Term
Synonyms DISEASE RHEUMATIC, Diseases Rheumatic, Enthesopathies, Enthesopathy, Rheumatic Disease, RHEUMATISM
Documents 2839
Hot Single Events 200
Hot Interactions 31

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Rheumatic Diseases. They are ordered first by their relevance to Rheumatic Diseases and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT285205 Binding of VEGFA and SLEB1 1 0.05 5.12 0.38 99.46
2 INT201940 Binding of IL8 and CXCL10 2 0.28 2.46 1.86 98.92
3 INT178087 EDN1 Positive_regulation of MMP13 2 0.23 1.58 0.59 96.80
4 INT182262 EDN1 Positive_regulation of Gene_expression of NOS2 1 0.28 0.79 0.31 96.80
5 INT182263 EDN1 Positive_regulation of MMP1 1 0.15 0.43 0.21 96.80
6 INT173946 Igf1 Regulation of Gene_expression of IGF1 1 0.08 0.68 0.21 96.24
7 INT173944 IGF1 Regulation of Gene_expression of Igf1 1 0.08 0.68 0.21 96.24
8 INT231764 TLR4 Negative_regulation of HMOX1 1 0.27 1.54 0.11 95.88
9 INT254283 Il10 Negative_regulation of Nfatc1 1 0.02 0.31 0.25 95.04
10 INT291625 Binding of CSTA and RAPGEF5 1 0.03 4.81 0.37 92.80
11 INT344797 Gene_expression of Il6 Negative_regulation of Mmp9 1 0.01 0.41 0.24 92.40
12 INT107596 Binding of PPA1 and OPLL 1 0.00 1.13 0.77 92.28
13 INT159593 Regulation of Nfkb1 Positive_regulation of Gene_expression of Nos2 1 0.38 0.46 0.74 92.12
14 INT34727 TNF Positive_regulation of Gene_expression of IL2 1 0.56 0.81 0.31 91.76
15 INT107602 Binding of OPLL and Enpp1 1 0.15 1.12 0.76 91.60
16 INT348173 Binding of HLA-B and IL23R 1 0.15 0.92 0.49 91.20
17 INT348177 Binding of HLA-B and ERAP1 1 0.14 0.92 0.49 91.20
18 INT231767 Positive_regulation of CD14 Positive_regulation of Binding of IRF6 1 0.04 1.6 0.11 88.72
19 INT231769 TNF Negative_regulation of Gene_expression of HMOX1 1 0.26 4.75 1.15 88.48
20 INT231770 CD14 Positive_regulation of Binding of IRF6 1 0.04 1.59 0.11 88.04
21 INT231755 CD14 Positive_regulation of Binding of IRF6 and TLR4 1 0.03 1.6 0.11 88.04
22 INT254357 Binding of IFNA1 and IL1B 1 0.00 1.88 0.51 87.36
23 INT254356 Binding of IFNG and IL1B 1 0.00 1.87 0.51 86.96
24 INT182124 Binding of IRF6 and TLR4 14 0.10 16.11 4.65 85.92
25 INT202038 MMP9 Positive_regulation of IL8 1 0.05 0.29 0.59 84.88
26 INT285748 PRL Positive_regulation of Positive_regulation of C6orf25 1 0.01 1.01 0.31 84.60
27 INT36084 Binding of HLA-DRB4 and Igkv16-104 1 0.04 1.01 0.51 83.52
28 INT239474 Binding of ACR and Ifx 1 0.02 0.36 0.45 82.28
29 INT183781 Binding of IL6 and INS 6 0.22 8.97 1.87 81.44
30 INT329956 Binding of IL2 and IL23R 1 0.33 4.58 1.21 80.24
31 INT329963 Binding of IL21 and IL23R 1 0.30 2.28 0.6 80.24
32 INT182266 EDN1 Positive_regulation of Gene_expression of MMP13 1 0.35 2.03 0.63 79.36
33 INT173945 Hrt1 Positive_regulation of Positive_regulation of IGF1 1 0.01 0.32 0.21 76.72
34 INT352269 Binding of Jund and Adora1 1 0.15 1.2 1.25 76.08
35 INT340437 Binding of SERPINH1 and HLA-DRB4 1 0.00 2.26 0.84 75.72
36 INT237679 IRF6 Positive_regulation of MAPK8 1 0.00 0.56 0.28 75.32
37 INT4339 Binding of OLAH and Cea 1 0.00 0.79 0.29 75.00
38 INT19645 Binding of HLA-B and KLRD1 1 0.00 0.73 0.15 75.00
39 INT313650 Binding of C8A and TRGC1 1 0.01 0.49 0.5 72.48
40 INT173936 Hrt1 Regulation of Gtf3a 1 0.00 1.16 0.44 69.92
41 INT122163 Binding of TNF and TNFRSF1B 6 0.44 6.06 2.41 68.32
42 INT243626 Twist1 Regulation of Hand1 1 0.15 1.55 0.72 67.64
43 INT248244 Binding of IL8 and SDC2 1 0.02 1.57 0.72 67.56
44 INT231763 Binding of HSPD1 and TLR2 1 0.12 2 0.19 66.88
45 INT231765 Binding of HSPD1 and TLR4 1 0.13 1.94 0.16 66.88
46 INT348175 Binding of NIDDM1 and PTPN22 1 0.01 2.36 0.99 62.64
47 INT220155 IL1RN Regulation of IL1B 2 0.50 0.93 0.61 60.56
48 INT231761 TNF Negative_regulation of HMOX1 1 0.19 1.2 0.12 60.56
49 INT121651 Binding of CXCL12 and CXCR4 13 0.48 17.61 3.52 59.28
50 INT175596 Binding of ACAT1 and HGF 1 0.01 1.58 0.18 58.64
51 INT254352 Binding of CXCR4 and Positive_regulation of Gene_expression of CXCL12 1 0.14 1.8 0.66 55.56
52 INT86179 TNF Positive_regulation of Localization of IL6 5 0.35 1.66 2.17 53.92
53 INT66257 Negative_regulation of Ptgs1 Positive_regulation of Gene_expression of Tnf 1 0.03 0.44 0.25 53.36
54 INT110315 Negative_regulation of ALOX5 Negative_regulation of Gene_expression of TNF 1 0.47 0.74 0.85 52.32
55 INT338940 Fpgs Positive_regulation of Mtx1 1 0.32 0.32 0.47 50.64
56 INT339819 SRP72 Regulation of SRP54 1 0.38 0.37 0.08 50.16
57 INT149117 Binding of CD80 and CTLA4 31 0.52 12.7 7.73 50.00
58 INT239037 Binding of Cd28 and Cd86 9 0.16 3.69 2.14 50.00
59 INT254355 PF4 Positive_regulation of IFNA1 1 0.04 1.23 1.26 50.00
60 INT139069 Binding of CTLA4 and Cd86 3 0.16 0.65 0.7 50.00
61 INT254348 Binding of ANGPT1 and TEK 1 0.04 1.72 0.48 50.00
62 INT254360 Binding of EPAS1 and HIF1A 3 0.39 3.36 0.46 50.00
63 INT254347 FASLG Negative_regulation of Gene_expression of CHI3L1 1 0.13 0.92 0.42 50.00
64 INT254350 FASLG Negative_regulation of Gene_expression of VEGFA 1 0.06 0.92 0.42 50.00
65 INT181995 TIMP1 Negative_regulation of Mmp9 1 0.01 1.38 0.4 50.00
66 INT254353 Binding of VEGFA and MMRN1 1 0.00 0.81 0.28 50.00
67 INT254359 IL1B Positive_regulation of Localization of VEGFA 1 0.01 0.87 0.26 50.00
68 INT254349 Positive_regulation of Binding of EPAS1 and HIF1A 1 0.00 0.92 0.23 50.00
69 INT254351 Binding of ANGPT2 and TEK 1 0.04 0.87 0.22 50.00
70 INT260099 Binding of COMP and IL4 1 0.00 0.18 0.09 50.00
71 INT172118 Binding of HSPA1B and C4b 1 0.39 0.92 0 50.00
72 INT260127 Binding of CD4 and Trav6-3 1 0.03 0 0 50.00
73 INT260128 Binding of ISG20 and Trav6-3 1 0.01 0 0 50.00
74 INT100274 IL1RN Negative_regulation of IL1B 5 0.53 1.79 1.65 49.92
75 INT186128 Binding of CD2 and CD58 8 0.10 7.59 2.76 49.16
76 INT186125 Negative_regulation of Binding of CD2 and CD58 3 0.12 3.04 1.06 49.16
77 INT262377 Binding of Comt and Fmod 1 0.06 1.47 1.29 48.92
78 INT62164 Il1b Positive_regulation of PTGS2 1 0.00 0.49 0.47 47.12
79 INT62163 Il1b Positive_regulation of Positive_regulation of PTGS2 1 0.00 0.49 0.47 47.12
80 INT240123 MIR885 Negative_regulation of IL1B 1 0.01 1.57 0.96 45.04
81 INT231771 Binding of HMOX1 and TNF 2 0.14 1.41 0.04 41.68
82 INT285750 IL1B Positive_regulation of Localization of PRL 1 0.05 1.51 0.39 39.72
83 INT285744 IL1B Regulation of Localization of PRL 1 0.05 1.51 0.39 39.72
84 INT285746 IL6 Regulation of Localization of PRL 1 0.08 1.51 0.39 39.48
85 INT285749 IL6 Positive_regulation of Localization of PRL 1 0.08 1.51 0.39 39.48
86 INT339822 SRP68 Positive_regulation of SRP72 1 0.33 0.28 0.05 38.56
87 INT181998 TNFRSF11B Negative_regulation of Gene_expression of CTSK 1 0.07 1.98 0.27 37.60
88 INT231772 TNF Positive_regulation of Gene_expression of HMOX1 1 0.21 0.96 0.1 35.04
89 INT211127 Regulation of Binding of MTX1 and TNF 1 0.22 0.71 0.74 34.16
90 INT211130 Binding of MTX1 and TNF 1 0.18 0.7 0.73 32.64
91 INT329297 Binding of Cd226 and Aff3 1 0.18 1.54 0.64 29.52
92 INT115367 Binding of IL6 and IL6R 12 0.07 8.16 2.36 27.92
93 INT264504 Binding of CRYGD and PTPN22 1 0.04 0.42 0.31 20.16
94 INT231758 IRF6 Regulation of Gene_expression of HMOX1 1 0.08 0.23 0.05 18.80
95 INT237683 Positive_regulation of LDHA Positive_regulation of MAPK8 1 0.02 0.16 0.03 17.84
96 INT182200 Binding of CXCR5 and CXCL13 1 0.37 2.89 2.07 17.52
97 INT237682 LDHA Positive_regulation of MAPK14 1 0.02 0.16 0.03 17.28
98 INT237680 LDHA Positive_regulation of MAPK8 1 0.02 0.16 0.03 17.28
99 INT182264 EDN1 Positive_regulation of Positive_regulation of MAPK14 1 0.26 0.1 0.05 16.68
100 INT202020 Binding of TYROBP and NCR1 1 0.01 0.36 0.09 15.60
101 INT180560 Binding of COMP and CYP27A1 1 0.12 0.47 0.18 14.32
102 INT248298 Binding of Cd40 and Rf 1 0.08 0 0 14.16
103 INT194647 Binding of CD28 and CD80 15 0.40 4.9 3.22 13.28
104 INT194646 Binding of CD28 and CD86 7 0.40 2.69 2.21 13.28
105 INT299793 Positive_regulation of Binding of CD86 and CTLA4 1 0.17 1.64 0.63 11.04
106 INT299792 Positive_regulation of Binding of CD80 and CTLA4 1 0.17 1.63 0.63 11.04
107 INT155484 Binding of CD86 and CTLA4 15 0.52 8.85 6.09 10.72
108 INT158400 Binding of CD80 and CD86 3 0.36 0.76 0.48 10.04
109 INT352970 IL4 Negative_regulation of Positive_regulation of TH1L 1 0.01 0.91 0.4 9.44
110 INT339816 SRP72 Regulation of Binding of SRP72 and UCN2 1 0.16 0.08 0 9.28
111 INT339817 Binding of SRP72 and UCN2 1 0.12 0.08 0 9.28
112 INT186126 Binding of CD28 and CTLA4 9 0.52 4.13 3.12 8.24
113 INT299785 CTLA4 Negative_regulation of Binding of CD28 2 0.17 1.8 0.5 8.24
114 INT299791 Negative_regulation of Binding of CD28 and CTLA4 1 0.18 0.77 0.32 8.24
115 INT288003 Binding of COL2A1 and PADI1 1 0.09 0.11 0.06 5.56
116 INT176477 Binding of CXCR3 and CXCL10 14 0.25 10.61 5.87 5.00
117 INT64718 IL1B Positive_regulation of Gene_expression of IL6 15 0.59 9.37 4.48 5.00
118 INT182194 Binding of IL8 and CXCR2 10 0.56 7.14 4.16 5.00
119 INT64719 IL1B Positive_regulation of IL6 7 0.41 6.84 3.14 5.00
120 INT130721 Binding of IL1B and IL1RN 6 0.05 5.29 2.85 5.00
121 INT175329 Binding of ICAM1 and ITGAL 14 0.18 10.06 2.81 5.00
122 INT31513 Crh Regulation of POMC 3 0.29 5.06 2.78 5.00
123 INT350148 Binding of IL12A and ERAL1 1 0.21 8.23 2.26 5.00
124 INT148704 Binding of TNF and TNFRSF1A 5 0.44 3.3 2.09 5.00
125 INT196586 Negative_regulation of Mapk14 Negative_regulation of TNF 2 0.04 2.02 2.08 5.00
126 INT97208 Binding of Gabrg1 and Gabbr1 2 0.07 0.31 1.94 5.00
127 INT102130 Il6 Positive_regulation of Gene_expression of Crp 4 0.05 7.39 1.91 5.00
128 INT89379 TNF Positive_regulation of Gene_expression of IL6 5 0.50 4.37 1.69 5.00
129 INT174503 Binding of HLA-B and KIR3DL1 6 0.37 3.48 1.61 5.00
130 INT254243 Binding of HOMER1 and MRI1 1 0.03 1.99 1.57 5.00
131 INT151849 IL10 Negative_regulation of Gene_expression of IL8 4 0.14 3.26 1.54 5.00
132 INT91456 IL1B Positive_regulation of Gene_expression of CPOX 6 0.17 3.36 1.53 5.00
133 INT201950 IFNA1 Positive_regulation of Binding of DPP4 1 0.12 2.17 1.47 5.00
134 INT201946 IFNA1 Positive_regulation of DPP4 1 0.17 2.16 1.46 5.00
135 INT131156 Binding of RUNX1 and TNF 2 0.03 3.44 1.42 5.00
136 INT240730 Binding of CRYGD and MTRF1 4 0.03 4.18 1.39 5.00
137 INT218309 Binding of CRP and IL6 3 0.23 4.78 1.36 5.00
138 INT201942 DPP4 Negative_regulation of CXCL10 1 0.33 0.9 1.3 5.00
139 INT202042 CAMK2N2 Negative_regulation of MMP9 1 0.01 0.73 1.25 5.00
140 INT202041 CAMK2N2 Negative_regulation of PPP1R11 1 0.00 0.74 1.25 5.00
141 INT202039 CAMK2N2 Negative_regulation of MMP1 1 0.00 0.73 1.24 5.00
142 INT202036 CAMK2N2 Negative_regulation of MMP3 1 0.00 0.73 1.24 5.00
143 INT202040 CAMK2N2 Negative_regulation of MMP7 1 0.00 0.73 1.24 5.00
144 INT197092 TNF Regulation of VEGFA 4 0.21 2.78 1.22 5.00
145 INT328743 TNF Positive_regulation of Mapk14 1 0.04 1.4 1.21 5.00
146 INT328742 Il1 Positive_regulation of Mapk14 1 0.01 1.4 1.2 5.00
147 INT340439 Binding of HLA-DMA and SUGT1 1 0.00 4.1 1.16 5.00
148 INT230019 Binding of HLA-B and ERAL1 1 0.00 2.23 1.1 5.00
149 INT119108 Binding of LTBR and TNF 2 0.15 1.47 1.07 5.00
150 INT329962 Binding of C5 and HEPACAM 1 0.03 2.25 1.06 5.00
151 INT329959 Binding of TRAF1 and HEPACAM 1 0.03 2.25 1.06 5.00
152 INT176474 Binding of CXCR3 and CXCL9 3 0.22 1.9 1.05 5.00
153 INT271875 IL1RN Negative_regulation of Binding of IL1B 1 0.01 1.3 1.01 5.00
154 INT206074 Binding of IL6 and IL6ST 7 0.32 3.79 1.01 5.00
155 INT228498 Il10 Negative_regulation of Hand1 1 0.03 1.4 0.99 5.00
156 INT228496 Il4 Negative_regulation of Hand1 1 0.02 1.4 0.99 5.00
157 INT91813 Binding of FAS and FASLG 4 0.23 9.89 0.99 5.00
158 INT228495 Il13 Negative_regulation of Hand1 1 0.01 1.4 0.98 5.00
159 INT103796 IL1B Positive_regulation of Gene_expression of SELE 2 0.08 1 0.98 5.00
160 INT103651 IL1B Positive_regulation of Gene_expression of IL8 6 0.78 1.23 0.98 5.00
161 INT103133 TNF Positive_regulation of Gene_expression of IL8 2 0.48 1.26 0.96 5.00
162 INT182203 Binding of CXCL1 and CXCR2 1 0.14 1.25 0.95 5.00
163 INT182190 Binding of IL8 and CXCR4 1 0.26 1.25 0.95 5.00
164 INT182207 Binding of CXCR2 and CXCL13 1 0.42 1.26 0.95 5.00
165 INT182208 Binding of CXCR2 and CXCL12 1 0.29 1.26 0.95 5.00
166 INT182210 Binding of CXCR4 and CXCL13 1 0.32 1.25 0.95 5.00
167 INT182193 Binding of CXCR2 and CXCL5 1 0.30 1.25 0.94 5.00
168 INT182206 Binding of CXCR5 and IL8 1 0.30 1.25 0.94 5.00
169 INT182188 Binding of CXCR5 and CXCL5 1 0.34 1.24 0.94 5.00
170 INT182199 Binding of CXCR5 and CXCL1 1 0.16 1.24 0.94 5.00
171 INT182197 Binding of CXCR2 and CCL16 1 0.00 1.24 0.94 5.00
172 INT182205 Binding of CXCL5 and CXCR4 1 0.29 1.24 0.94 5.00
173 INT133050 TNF Positive_regulation of Gene_expression of ICAM1 3 0.67 1.91 0.94 5.00
174 INT182198 Binding of CXCR5 and CXCL12 1 0.33 1.25 0.94 5.00
175 INT182195 Binding of CXCL1 and CXCR4 1 0.13 1.25 0.94 5.00
176 INT336017 Vip Regulation of Tlr4 1 0.22 1.23 0.93 5.00
177 INT182189 Binding of CXCL1 and CXCL13 1 0.14 1.24 0.93 5.00
178 INT182209 Binding of CXCL12 and CXCL13 1 0.30 1.24 0.93 5.00
179 INT182196 Binding of IL8 and CXCL13 1 0.27 1.24 0.93 5.00
180 INT182204 Binding of CXCL5 and CXCL13 1 0.30 1.24 0.93 5.00
181 INT254242 TNF Positive_regulation of Gene_expression of DKK1 1 0.14 1.24 0.91 5.00
182 INT211128 Binding of P4HB and TNF 1 0.09 0.97 0.9 5.00
183 INT211129 Negative_regulation of Binding of P4HB and TNF 1 0.10 0.97 0.9 5.00
184 INT277832 Binding of TNFRSF1B and NPEPPS 1 0.01 1.1 0.88 5.00
185 INT277831 Binding of TNFRSF1A and NPEPPS 1 0.01 1.1 0.87 5.00
186 INT209881 Binding of TNFRSF11B and TNFSF11 8 0.36 8.92 0.86 5.00
187 INT232417 Binding of Mtx1 and Ifx 1 0.04 0.99 0.86 5.00
188 INT271511 Binding of Phb2 and Glrb 1 0.04 1.7 0.84 5.00
189 INT182636 Binding of TNFSF11 and TNFRSF11A 16 0.29 17.5 0.84 5.00
190 INT287494 CRP Positive_regulation of Gene_expression of CCL2 2 0.30 2.33 0.83 5.00
191 INT320120 MTX1 Positive_regulation of PTEN 1 0.04 0.09 0.82 5.00
192 INT231693 Binding of IGKV2-19 and BDNF-AS 1 0.00 2.39 0.81 5.00
193 INT201945 Binding of CXCR1 and CXCR2 3 0.14 0.84 0.8 5.00
194 INT239064 Binding of Mbl1 and IgG 1 0.03 2.59 0.78 5.00
195 INT207391 Il17a Positive_regulation of Gene_expression of Tnfsf11 2 0.05 1.19 0.77 5.00
196 INT348174 Binding of STAT3 and IL23R 1 0.40 1.9 0.76 5.00
197 INT173112 IL1B Positive_regulation of Gene_expression of VCAM1 2 0.43 1.34 0.76 5.00
198 INT149192 TNF Positive_regulation of Gene_expression of VCAM1 3 0.57 1.4 0.76 5.00
199 INT176473 IL10 Positive_regulation of Gene_expression of PECAM1 1 0.05 1.1 0.75 5.00
200 INT201941 IFNA1 Positive_regulation of Gene_expression of CXCL10 1 0.14 1.09 0.74 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Rheumatic Diseases. They are ordered first by their pain relevance and then by number of times they were reported in Rheumatic Diseases. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT1878 Binding of HLA-B 440 0.48 321.16 127.36 100.00
2 INT1873 Gene_expression of MRAP 51 0.76 31.75 13.92 100.00
3 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 100.00
4 INT118095 Regulation of COMP 7 0.43 9.69 3.33 100.00
5 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 100.00
6 INT344052 Negative_regulation of Positive_regulation of Btg3 1 0.36 1.44 0.19 100.00
7 INT2249 Negative_regulation of Binding of HLA-B 5 0.54 6.82 2.94 100.00
8 INT3055 Binding of OLAH 9 0.28 7.14 3.99 100.00
9 INT43874 Negative_regulation of Binding of OLAH 1 0.03 0.97 0.43 100.00
10 INT172020 Localization of Acr 1 0.06 0.61 0.31 100.00
11 INT9660 Regulation of TNF 363 0.62 312.94 139.99 99.96
12 INT64065 Gene_expression of Btg3 5 0.65 12.62 1.41 99.92
13 INT183967 Positive_regulation of Btg3 9 0.58 9.04 1.03 99.92
14 INT311029 Positive_regulation of Gene_expression of Btg3 2 0.42 2.43 0.17 99.92
15 INT237703 Phosphorylation of IRF6 2 0.05 0.91 0.47 99.92
16 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 99.88
17 INT10285 Binding of ADRA1D 102 0.47 25.82 31.11 99.84
18 INT34904 Negative_regulation of Gtf3a 48 0.15 38.88 13.73 99.80
19 INT1973 Positive_regulation of NAGLU 36 0.65 14.78 7 99.80
20 INT6021 Binding of PRL 18 0.48 12.55 4.3 99.80
21 INT238902 Binding of TGS1 3 0.07 2.86 0.36 99.80
22 INT749 Gene_expression of HLA-B 341 0.75 224.12 77.37 99.70
23 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 99.66
24 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 99.64
25 INT86705 Gene_expression of BTG3 41 0.65 37.29 8.29 99.64
26 INT288274 Transcription of MTRF1 1 0.04 0.59 0.14 99.64
27 INT288272 Transcription of AFA 1 0.55 0.58 0.14 99.64
28 INT39406 Positive_regulation of OLR1 45 0.70 37.8 7.72 99.64
29 INT94437 Positive_regulation of Gene_expression of OLR1 17 0.70 16.04 2.8 99.64
30 INT100582 Positive_regulation of Stil 2 0.49 1.69 1.33 99.64
31 INT288271 Transcription of CRYGD 1 0.17 0.53 0.14 99.64
32 INT279122 Regulation of Gene_expression of COMP 3 0.39 8.82 3.19 99.60
33 INT116528 Gene_expression of HMOX1 106 0.78 86.13 12.8 99.56
34 INT16720 Negative_regulation of Xdh 35 0.59 14 6.67 99.54
35 INT6488 Gene_expression of Tnf 484 0.78 339.61 191.58 99.52
36 INT23402 Binding of HLA-DOA 74 0.48 52.01 10.89 99.52
37 INT77955 Negative_regulation of PCS 55 0.43 39.32 5.76 99.48
38 INT133826 Negative_regulation of Kdm5d 15 0.16 7.88 1.83 99.48
39 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 99.46
40 INT3179 Positive_regulation of SCT 15 0.50 4.79 1.98 99.44
41 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 99.40
42 INT100912 Regulation of Kdm5d 52 0.32 20.39 4.72 99.40
43 INT8541 Gene_expression of Csrp1 42 0.76 23.72 6.9 99.36
44 INT5788 Gene_expression of IL2RA 60 0.75 40.67 9.98 99.32
45 INT46637 Gene_expression of CXCL10 172 0.78 121.94 57.74 99.30
46 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 99.30
47 INT123701 Negative_regulation of VDR 61 0.59 48.94 9.67 99.28
48 INT82398 Binding of HLA-DMB 3 0.35 3.82 1.66 99.28
49 INT15132 Gene_expression of TNFRSF1A 33 0.75 20.09 5.93 99.28
50 INT284037 Localization of Dhdds 1 0.24 1.14 0.35 99.28
51 INT115002 Binding of ELAVL2 1 0.31 0.29 0.15 99.28
52 INT117223 Gene_expression of TLR4 348 0.78 206.18 54.42 99.24
53 INT45324 Positive_regulation of Otc 8 0.59 3.94 3.36 99.24
54 INT8798 Positive_regulation of Csrp1 61 0.69 63.86 14.14 99.24
55 INT143158 Negative_regulation of Gene_expression of TLR4 31 0.56 20.62 5.69 99.24
56 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07 99.22
57 INT37430 Gene_expression of Gpi1 61 0.63 54.63 13.87 99.20
58 INT69396 Gene_expression of H2-K1 72 0.65 38.16 4.56 99.16
59 INT69397 Regulation of Gene_expression of H2-K1 9 0.23 6.32 0.91 99.16
60 INT71786 Phosphorylation of MAPK1 256 0.82 110.09 46.17 99.12
61 INT109929 Phosphorylation of MAPK8 102 0.81 39.98 16.54 99.12
62 INT110178 Phosphorylation of MAPK14 40 0.68 19.38 10.37 99.12
63 INT4509 Gene_expression of IgG 426 0.76 293.69 56.64 99.04
64 INT116527 Positive_regulation of Gene_expression of HMOX1 29 0.70 25.79 4.87 99.00
65 INT127283 Regulation of Gene_expression of HMOX1 14 0.61 11.8 1.28 99.00
66 INT37193 Negative_regulation of BDNF-AS 21 0.37 15.06 3.12 99.00
67 INT211970 Negative_regulation of Best1 49 0.14 37.33 2.32 98.96
68 INT18954 Negative_regulation of OLAH 9 0.09 8.31 3.67 98.94
69 INT9261 Gene_expression of CR1 15 0.73 15.58 1.85 98.92
70 INT306748 Gene_expression of Stil 1 0.58 1.47 0.84 98.92
71 INT82829 Gene_expression of COMP 104 0.78 57 9.81 98.88
72 INT162258 Negative_regulation of Gene_expression of COMP 35 0.58 19.14 3.55 98.88
73 INT22916 Negative_regulation of CR1 12 0.57 6.31 2.42 98.88
74 INT163134 Gene_expression of ACR 78 0.65 30.39 38.48 98.88
75 INT23126 Regulation of HTR3A 10 0.60 5.42 4.81 98.88
76 INT116465 Gene_expression of Birc5 241 0.78 192.31 15.32 98.84
77 INT6852 Localization of TNF 883 0.81 705.95 270.84 98.72
78 INT636 Binding of MRAP 54 0.48 40.36 18.77 98.72
79 INT94438 Gene_expression of OLR1 86 0.78 80.38 11.03 98.72
80 INT131488 Binding of MAS1 9 0.36 8.49 1.01 98.72
81 INT16404 Regulation of CD4 54 0.61 33.05 10.29 98.64
82 INT50212 Gene_expression of Ifx 33 0.75 32.17 7.26 98.64
83 INT915 Positive_regulation of PRL 342 0.70 141.96 104.31 98.56
84 INT180353 Binding of AMELX 10 0.04 15.34 0.4 98.56
85 INT180355 Binding of AIRE 1 0.06 7.13 0.05 98.56
86 INT83886 Negative_regulation of HMOX2 27 0.43 11.69 10.78 98.36
87 INT135773 Negative_regulation of Gene_expression of HMOX1 31 0.53 28.31 3.32 98.32
88 INT344053 Negative_regulation of Gene_expression of Btg3 1 0.36 2.95 0.22 98.32
89 INT30117 Gene_expression of Calm1 18 0.71 17.45 13.18 98.32
90 INT11699 Binding of HLA-E 85 0.47 52.51 13.41 98.28
91 INT114084 Binding of ATP8A1 1 0.01 0.42 0.1 98.28
92 INT6580 Negative_regulation of Ptgs1 929 0.59 381.53 376.26 98.20
93 INT16364 Gene_expression of HLA-DRA 234 0.78 118.81 45.01 98.12
94 INT63035 Gene_expression of CSTA 10 0.56 11.56 0.57 98.12
95 INT34585 Negative_regulation of Positive_regulation of HSD11B1 31 0.57 43.54 2.47 98.12
96 INT96663 Binding of FABP6 1 0.47 3.17 1.45 98.04
97 INT111223 Positive_regulation of HMOX1 47 0.70 39.14 10.92 98.04
98 INT28300 Gene_expression of GHR 10 0.78 4.29 1.5 98.00
99 INT184168 Localization of GHR 1 0.08 0.34 0.05 98.00
100 INT748 Transcription of HLA-B 6 0.67 1.56 0.91 97.88
101 INT70619 Regulation of Bmp2 6 0.60 3.1 1.29 97.76
102 INT145301 Regulation of Gene_expression of Bmp2 1 0.32 1.16 0.48 97.76
103 INT145304 Regulation of Gene_expression of Sox9 1 0.43 1.04 0.46 97.76
104 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 97.72
105 INT47915 Negative_regulation of NAGLU 2 0.22 0.66 0.42 97.72
106 INT120371 Gene_expression of FEZF2 12 0.66 4.97 1.38 97.72
107 INT117598 Regulation of ACR 118 0.26 41.25 48.01 97.68
108 INT82451 Negative_regulation of HMOX1 18 0.51 13.29 5.74 97.68
109 INT183966 Localization of Btg3 2 0.63 2.94 0.45 97.68
110 INT8640 Positive_regulation of HSD11B1 332 0.67 377.84 22.36 97.68
111 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61 97.60
112 INT92236 Regulation of Gene_expression of CXCL10 6 0.42 7.12 4.92 97.52
113 INT184171 Localization of FEZF2 1 0.12 0.34 0.05 97.50
114 INT2604 Positive_regulation of Got1 223 0.70 154.78 49.51 97.48
115 INT22223 Positive_regulation of Xdh 18 0.67 5.87 3.84 97.48
116 INT190418 Positive_regulation of AAVS1 15 0.49 4.71 0.98 97.48
117 INT3361 Positive_regulation of Esr1 273 0.69 208.53 44.81 97.40
118 INT764 Gene_expression of OLAH 25 0.67 25.58 8.07 97.36
119 INT4067 Negative_regulation of Esr1 97 0.50 43.45 17.52 97.28
120 INT134646 Gene_expression of Tnfsf11 19 0.69 14.77 4.16 97.24
121 INT294998 Positive_regulation of Gene_expression of Tnfsf11 5 0.62 2.98 0.79 97.24
122 INT51921 Gene_expression of Cpox 501 0.73 229.81 157.81 97.16
123 INT106745 Localization of CRP 65 0.81 66.44 15.21 97.16
124 INT192762 Localization of SAA1 10 0.78 12.63 1.44 97.16
125 INT220216 Gene_expression of HUNK 1 0.41 14.77 4.24 97.12
126 INT15516 Gene_expression of Crp 711 0.77 615.33 173.09 97.12
127 INT84464 Gene_expression of DPP4 101 0.78 56.15 17.53 97.12
128 INT546 Binding of ALB 311 0.48 85.98 60.14 97.08
129 INT79395 Gene_expression of Twist1 193 0.77 100.06 26.34 97.08
130 INT637 Positive_regulation of MRAP 23 0.67 21.13 9.97 97.04
131 INT76838 Binding of Asprv1 7 0.36 1.42 3.13 97.04
132 INT3374 Positive_regulation of Positive_regulation of MRAP 1 0.49 0.7 0.07 97.04
133 INT4697 Positive_regulation of Gene_expression of HLA-B 32 0.61 17.32 5.97 96.92
134 INT1127 Negative_regulation of IGHG3 32 0.28 21.1 7.37 96.84
135 INT1124 Negative_regulation of CD40LG 53 0.57 36.26 7 96.84
136 INT231694 Negative_regulation of IGKV2-19 14 0.03 7.09 2.64 96.80
137 INT8662 Positive_regulation of EDN1 144 0.70 125.34 19.59 96.80
138 INT3128 Negative_regulation of PON1 30 0.59 26.19 4.57 96.74
139 INT79167 Localization of TNC 8 0.78 4.15 1.44 96.72
140 INT16996 Gene_expression of PRTN3 113 0.75 85.61 22.57 96.52
141 INT3623 Negative_regulation of CTSB 49 0.55 27.39 13.52 96.52
142 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 96.48
143 INT171997 Gene_expression of ERAL1 5 0.25 4.97 1.67 96.36
144 INT6481 Binding of TNF 624 0.48 510.2 214.82 96.32
145 INT955 Gene_expression of GHRH 126 0.78 59.91 20.74 96.32
146 INT77675 Gene_expression of Saa 40 0.58 43.37 18.69 96.28
147 INT93663 Positive_regulation of MMP1 72 0.67 33.38 19.86 96.28
148 INT123779 Positive_regulation of MMP13 42 0.65 24.3 12.45 96.28
149 INT260118 Regulation of Regulation of CD4 1 0.44 1.66 0.4 96.24
150 INT107599 Negative_regulation of Enpp1 8 0.51 6.02 1.24 96.24
151 INT71878 Protein_catabolism of Nfkb1 24 0.65 10.85 9.46 96.20
152 INT65474 Positive_regulation of Binding of TNFRSF13C 1 0.41 1.21 0.07 96.16
153 INT25152 Gene_expression of SAA1 37 0.75 53.56 8.07 96.16
154 INT279130 Negative_regulation of Localization of COMP 5 0.51 3.75 0.69 96.12
155 INT118097 Localization of COMP 18 0.70 9.99 1.42 96.12
156 INT32203 Negative_regulation of Crp 48 0.58 32.77 11.89 96.08
157 INT1474 Regulation of Localization of Ins1 132 0.61 25.96 43.07 96.00
158 INT168600 Binding of Mmp9 14 0.44 12.79 6.92 96.00
159 INT91527 Gene_expression of CTSK 38 0.78 22.21 7.42 95.88
160 INT145767 Negative_regulation of TLR4 18 0.43 11.03 5.25 95.88
161 INT65473 Binding of TNFRSF13C 1 0.31 1.2 0.07 95.80
162 INT48901 Negative_regulation of IL6 186 0.57 136.33 57.87 95.68
163 INT2006 Gene_expression of fc 104 0.34 64.91 19.08 95.68
164 INT19185 Negative_regulation of Cd4 80 0.51 61.32 8.51 95.64
165 INT1114 Localization of Ins1 748 0.80 192.95 165.48 95.56
166 INT15849 Gene_expression of FRTS 27 0.58 7.14 5.14 95.36
167 INT81530 Gene_expression of Nfkb1 93 0.78 48.58 32.58 95.24
168 INT81531 Positive_regulation of Gene_expression of Nfkb1 27 0.69 13.9 11.04 95.24
169 INT96423 Gene_expression of Bmp2 61 0.78 25.07 3.01 95.16
170 INT145306 Gene_expression of Sox9 5 0.54 2.47 0.8 95.16
171 INT23465 Gene_expression of S100b 31 0.76 15.09 6.2 95.04
172 INT79693 Regulation of Il4 30 0.51 21.96 8.6 94.84
173 INT69985 Positive_regulation of Negative_regulation of TNF 21 0.50 13.26 6.31 94.80
174 INT1876 Positive_regulation of HLA-B 82 0.69 52.16 21.08 94.72
175 INT11823 Positive_regulation of GGT1 53 0.67 45.84 7.55 94.56
176 INT9852 Positive_regulation of Gpt 563 0.70 364.64 146.82 94.52
177 INT38814 Positive_regulation of Aspt1 9 0.63 6.89 3.06 94.52
178 INT65054 Positive_regulation of Nfkb1 285 0.70 149.33 126.73 94.48
179 INT137180 Binding of CXCR3 10 0.41 4.24 3.53 94.48
180 INT201958 Negative_regulation of Binding of CXCR3 1 0.24 0.81 0.47 94.48
181 INT66029 Negative_regulation of Tnf 100 0.59 84.28 48.16 94.44
182 INT113186 Gene_expression of Prf1 46 0.53 21.06 5.32 94.36
183 INT95369 Positive_regulation of Gene_expression of NOS2 36 0.55 25.09 11.37 94.36
184 INT148207 Gene_expression of CTLA4 53 0.77 29.13 12.07 94.28
185 INT52795 Regulation of Btg3 3 0.38 1.58 1.77 94.24
186 INT64725 Regulation of Transcription of IL6 9 0.45 7.96 3.49 94.24
187 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 94.16
188 INT49214 Gene_expression of Cd4 269 0.78 154.22 34.05 94.12
189 INT68299 Binding of Tnf 17 0.39 12.55 7.49 94.08
190 INT94335 Positive_regulation of CXCL10 71 0.58 50.69 23 94.04
191 INT187158 Positive_regulation of Positive_regulation of CXCL10 2 0.38 1.6 1.03 94.04
192 INT34869 Negative_regulation of PTGS2 778 0.59 366.76 319.85 94.00
193 INT67597 Negative_regulation of Das 17 0.37 9.95 5.05 93.92
194 INT28950 Positive_regulation of Gene_expression of IGF1 99 0.69 46.9 16.47 93.92
195 INT61626 Transcription of IL6 73 0.72 42.04 17.86 93.88
196 INT171096 Transcription of PDGFA 5 0.47 4.42 0.79 93.88
197 INT79060 Gene_expression of NOS2 116 0.78 69.25 34.84 93.84
198 INT7126 Negative_regulation of PLA2G2A 26 0.58 12.97 5.64 93.80
199 INT1759 Gene_expression of TIMP1 267 0.77 133.87 59.29 93.76
200 INT313673 Negative_regulation of C8A 1 0.04 0.85 0.82 93.60
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