D:Rheumatic Fever

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Disease Term
Synonyms ACUTE ARTICULAR RHEUMATISM, Acute Articular Rheumatisms, Acute Rheumatic Arthritides, Acute Rheumatic Arthritis, Acute Rheumatic Arthritis Disorder, ACUTE RHEUMATISM, Arthritides Acute Rheumatic, Arthritis Acute Rheumatic, Arthritis Rheumatic Acute, Articular Rheumatism Acute, ARTICULAR RHEUMATISMS ACUTE
Documents 217
Hot Single Events 29
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Rheumatic Fever. They are ordered first by their relevance to Rheumatic Fever and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT101942 Binding of CD40 and CD40LG 16 0.23 15.24 4.01 5.00
2 INT236365 Binding of CD40LG and IL6 3 0.20 4.16 1.42 5.00
3 INT278292 Binding of CRP and ESR1 6 0.09 10.92 0.96 5.00
4 INT282506 ocd Positive_regulation of Gene_expression of Comt 1 0.32 1.26 0.84 5.00
5 INT236364 CD40LG Positive_regulation of Gene_expression of IL6 1 0.25 1.37 0.72 5.00
6 INT282505 Binding of ocd and Slc1a1 1 0.39 4.22 0.4 5.00
7 INT282501 Negative_regulation of Cyp19a1 Negative_regulation of Gene_expression of Aaiq4 1 0.01 0.6 0.27 5.00
8 INT226073 Binding of CRP and SHBG 2 0.10 2.14 0.24 5.00
9 INT283520 Binding of DLAT and Pain1 1 0.27 0.65 0.22 5.00
10 INT259023 CADPS Positive_regulation of Binding of SH2B2 1 0.06 2.05 0.14 5.00
11 INT283460 Binding of CTLA4 and DLAT 1 0.06 3.14 0.09 5.00
12 INT283521 PREB Regulation of Fam89b 1 0.00 1.08 0.07 5.00
13 INT283464 Binding of CD4 and DLAT 1 0.07 0.69 0.04 5.00
14 INT296893 Nps Negative_regulation of Gene_expression of REN 1 0.00 1.05 0.04 5.00
15 INT278291 Binding of CRP and DBP 1 0.12 1.57 0.03 5.00
16 INT278289 Binding of DBP and ESR1 1 0.03 0.82 0.03 5.00
17 INT283463 Binding of DLAT and GAGE4 1 0.00 1.1 0.03 5.00
18 INT282503 Binding of ocd and Dlgap3 1 0.28 1.58 0.03 5.00
19 INT283462 Binding of DLAT and HLA-DRB1 1 0.07 1.06 0.03 5.00
20 INT278294 Binding of ESR1 and SHBG 1 0.01 0.82 0.03 5.00
21 INT278290 Binding of CRP and PADI4 1 0.11 1.2 0.03 5.00
22 INT352175 USE1 Regulation of NAGA 1 0.01 0.33 0 5.00
23 INT180164 Gast Positive_regulation of Nfasc 1 0.02 1.31 0 5.00
24 INT278295 DBP Positive_regulation of SHBG 1 0.02 0.92 0 5.00
25 INT252020 Binding of HLA-A and ELOVL1 1 0.01 1.41 0 5.00
26 INT282504 Binding of Grik2 and Grik3 1 0.27 0.61 0 5.00
27 INT278293 Binding of DBP and SHBG 2 0.02 1.34 0 5.00
28 INT282507 Binding of Grik3 and ocd 1 0.25 0.61 0 5.00
29 INT282502 Negative_regulation of Binding of ocd and Slc1a1 1 0.30 0.48 0 5.00
30 INT283461 Binding of IL2 and SLC4A2 1 0.01 0.98 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Rheumatic Fever. They are ordered first by their pain relevance and then by number of times they were reported in Rheumatic Fever. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT2105 Negative_regulation of Rhd 10 0.41 4.9 3.4 100.00
2 INT2103 Localization of Rhd 35 0.77 3.16 23.5 100.00
3 INT61140 Regulation of Negative_regulation of Rf 1 0.05 1.45 0.1 100.00
4 INT9837 Negative_regulation of Rf 12 0.11 8.41 4.55 100.00
5 INT61076 Gene_expression of RHD 9 0.65 3.52 1.39 100.00
6 INT90 Localization of Gast 400 0.81 137.67 113 99.28
7 INT7253 Negative_regulation of Localization of Gast 70 0.59 21.06 20.06 99.28
8 INT180160 Positive_regulation of Binding of Gast 2 0.32 2.72 0.12 99.24
9 INT233 Binding of Gast 31 0.42 17.07 5.21 99.24
10 INT2093 Gene_expression of GAST 50 0.78 32.32 7.98 99.16
11 INT13556 Gene_expression of CD4 367 0.78 230.82 41.74 99.16
12 INT131788 Positive_regulation of NPPB 87 0.67 86.1 8.81 98.96
13 INT4137 Positive_regulation of C3 73 0.69 48.57 12.63 95.36
14 INT1123 Positive_regulation of CD79A 74 0.70 51.96 7.14 95.36
15 INT4075 Positive_regulation of Gene_expression of Gast 24 0.68 19.99 4.02 94.44
16 INT62950 Gene_expression of NPPB 73 0.75 65.91 6.54 93.80
17 INT93789 Gene_expression of Tnnc1 28 0.76 17.3 1.99 93.80
18 INT30 Gene_expression of Gast 158 0.78 99 41.45 93.52
19 INT68829 Binding of ELF3 14 0.47 7.96 2 90.96
20 INT6481 Binding of TNF 624 0.48 510.2 214.82 87.16
21 INT9408 Positive_regulation of Crp 296 0.69 242.27 57.35 87.12
22 INT82768 Binding of MLRG 5 0.23 0.54 2.22 86.96
23 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 86.68
24 INT183746 Positive_regulation of Positive_regulation of NNT 1 0.29 0.63 0 86.32
25 INT183747 Positive_regulation of NNT 1 0.44 0.63 0 86.32
26 INT50058 Negative_regulation of Cpox 907 0.58 426.28 428.29 85.12
27 INT56985 Gene_expression of MEFV 56 0.71 46.71 9.47 83.04
28 INT6473 Positive_regulation of Gene_expression of IL1B 204 0.70 117.23 50.86 82.64
29 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 82.28
30 INT129358 Gene_expression of ELOVL1 23 0.66 29.39 2.83 76.80
31 INT636 Binding of MRAP 54 0.48 40.36 18.77 75.00
32 INT259952 Negative_regulation of Negative_regulation of ALB 1 0.42 1.24 0.04 74.88
33 INT3952 Negative_regulation of ALB 116 0.59 72.18 18.35 74.60
34 INT10207 Gene_expression of PADI4 22 0.75 23.49 1.74 71.96
35 INT175262 Binding of SH2B2 18 0.36 22.85 3.18 69.44
36 INT282483 Regulation of ocd 1 0.33 2.43 0.24 66.96
37 INT1125 Positive_regulation of IGHG3 130 0.69 112.07 13.18 64.24
38 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 61.12
39 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 60.40
40 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 60.40
41 INT18010 Positive_regulation of CD40LG 122 0.70 100.8 18.46 59.56
42 INT16671 Gene_expression of MBTPS1 7 0.30 4.8 0.52 58.56
43 INT16184 Negative_regulation of CHKB 20 0.53 10.61 1.42 53.88
44 INT24816 Binding of CD40LG 68 0.47 45.48 11.56 50.76
45 INT11051 Positive_regulation of Gene_expression of IL6 415 0.69 319.21 109.3 50.56
46 INT304592 Regulation of Spir1 1 0.04 0.94 0.03 48.08
47 INT160576 Gene_expression of Psgb1 3 0.35 1.63 1.08 41.12
48 INT128376 Binding of KIT 26 0.48 14.24 0.47 37.00
49 INT66423 Binding of ELOVL1 52 0.40 61.63 5.16 36.96
50 INT66191 Gene_expression of DBP 42 0.66 22.25 3.18 36.24
51 INT749 Gene_expression of HLA-B 341 0.75 224.12 77.37 34.08
52 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 33.92
53 INT18773 Localization of ALB 117 0.80 69.18 13.8 33.92
54 INT355025 Positive_regulation of Binding of HPD 1 0.10 0.63 0 30.56
55 INT269716 Binding of HPD 3 0.31 1.42 0.08 29.48
56 INT169173 Gene_expression of ocd 9 0.50 4.49 1.28 20.40
57 INT11183 Negative_regulation of SH2B2 4 0.34 6.99 2.12 20.04
58 INT31 Negative_regulation of Gene_expression of Gast 10 0.42 5.3 3.34 19.04
59 INT153300 Negative_regulation of Gene_expression of CRP 48 0.58 39.97 7.58 18.04
60 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 17.84
61 INT100861 Binding of CRP 179 0.48 175.2 26.45 16.80
62 INT20944 Gene_expression of Mcf2l 13 0.58 5.96 4.76 16.48
63 INT9694 Positive_regulation of Csf2 102 0.68 70.09 33.07 6.24
64 INT9082 Positive_regulation of ESR1 238 0.69 148.51 36.69 5.40
65 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 5.00
66 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 5.00
67 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 5.00
68 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 5.00
69 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 5.00
70 INT15516 Gene_expression of Crp 711 0.77 615.33 173.09 5.00
71 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 5.00
72 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 5.00
73 INT60526 Gene_expression of IL10 449 0.78 292.71 107.84 5.00
74 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 5.00
75 INT12082 Localization of IL6 365 0.81 241.78 105.78 5.00
76 INT10838 Positive_regulation of IL8 381 0.70 295.51 101.62 5.00
77 INT11381 Positive_regulation of IL1B 330 0.70 209.31 100.9 5.00
78 INT1724 Negative_regulation of ACE 437 0.59 315.64 74.48 5.00
79 INT56298 Gene_expression of IL4 306 0.78 182.18 72.92 5.00
80 INT14049 Positive_regulation of GRIN1 102 0.70 48.31 71.06 5.00
81 INT5374 Gene_expression of Esr1 412 0.77 263.89 67.34 5.00
82 INT546 Binding of ALB 311 0.48 85.98 60.14 5.00
83 INT35975 Regulation of Cpox 109 0.39 57.88 49.69 5.00
84 INT51163 Gene_expression of Gal 119 0.78 67.48 49.23 5.00
85 INT16364 Gene_expression of HLA-DRA 234 0.78 118.81 45.01 5.00
86 INT3361 Positive_regulation of Esr1 273 0.69 208.53 44.81 5.00
87 INT4216 Gene_expression of CD40LG 328 0.78 256.02 44.23 5.00
88 INT73502 Positive_regulation of IL10 154 0.69 124.87 43.5 5.00
89 INT89 Positive_regulation of Gast 187 0.70 80.49 42.07 5.00
90 INT16455 Gene_expression of Drd2 116 0.78 22.71 38.47 5.00
91 INT9239 Regulation of Gene_expression of IL6 106 0.61 75.24 36.53 5.00
92 INT6484 Binding of IL1B 122 0.47 75.84 35.07 5.00
93 INT1705 Gene_expression of pCA 126 0.65 88.65 34.81 5.00
94 INT47710 Negative_regulation of GRIN1 71 0.57 25.57 34.24 5.00
95 INT10763 Localization of IL2 157 0.80 81.11 33.21 5.00
96 INT73498 Gene_expression of IL13 117 0.44 83.85 32.26 5.00
97 INT7538 Negative_regulation of IL2 95 0.57 47.31 31.7 5.00
98 INT9053 Negative_regulation of ALOX5 97 0.58 40.34 29.94 5.00
99 INT91 Positive_regulation of Localization of Gast 96 0.70 23.22 29.36 5.00
100 INT86437 Binding of IL6 154 0.48 121.22 29.3 5.00
101 INT67912 Gene_expression of GRIN1 75 0.77 28.99 29.28 5.00
102 INT8097 Gene_expression of EGF 122 0.77 75.94 28.47 5.00
103 INT69157 Gene_expression of IL5 127 0.77 102.58 26.81 5.00
104 INT3760 Positive_regulation of ALB 142 0.70 87.46 26.7 5.00
105 INT17739 Gene_expression of S100B 226 0.78 132.7 26.4 5.00
106 INT101120 Gene_expression of Comt 63 0.77 34.75 26.13 5.00
107 INT130176 Positive_regulation of Gene_expression of CRP 125 0.66 137.06 25.9 5.00
108 INT61664 Regulation of GRIN1 38 0.60 16.45 25.35 5.00
109 INT11659 Gene_expression of COL2A1 164 0.78 78.49 22.58 5.00
110 INT16996 Gene_expression of PRTN3 113 0.75 85.61 22.57 5.00
111 INT3299 Positive_regulation of AGT 126 0.68 79.45 21.91 5.00
112 INT34488 Negative_regulation of MMP2 85 0.59 41.98 21.72 5.00
113 INT5916 Positive_regulation of HTR1A 51 0.67 18.27 21.38 5.00
114 INT5328 Positive_regulation of CD4 191 0.69 133.43 21.31 5.00
115 INT129987 Phosphorylation of Gria1 63 0.80 20.65 21.02 5.00
116 INT955 Gene_expression of GHRH 126 0.78 59.91 20.74 5.00
117 INT62042 Positive_regulation of Gene_expression of IL4 67 0.56 42.05 20.39 5.00
118 INT105021 Binding of GOPC 187 0.40 60.39 20.38 5.00
119 INT9237 Regulation of Gene_expression of IL1B 49 0.62 30.69 20.34 5.00
120 INT125312 Positive_regulation of COPD 134 0.59 162.55 20.27 5.00
121 INT78024 Gene_expression of ACLY 73 0.75 59.15 18.54 5.00
122 INT14306 Positive_regulation of Gal 36 0.70 21.66 18.51 5.00
123 INT73252 Positive_regulation of Mthfd1 124 0.59 59.48 18.35 5.00
124 INT17442 Gene_expression of ALOX5 110 0.75 51.55 18.29 5.00
125 INT14724 Negative_regulation of CYP19A1 233 0.59 96.56 18.26 5.00
126 INT80755 Gene_expression of CD40 88 0.75 53.68 17.86 5.00
127 INT59365 Gene_expression of HTR1A 41 0.75 16.31 16.57 5.00
128 INT10000 Regulation of Gene_expression of IL2 56 0.45 15.33 16.2 5.00
129 INT3793 Regulation of CEBPZ 59 0.61 20.91 15.83 5.00
130 INT5333 Gene_expression of NPEPPS 45 0.65 26.34 15.25 5.00
131 INT7997 Gene_expression of Ltc4s 51 0.76 34.28 13.8 5.00
132 INT65697 Positive_regulation of GRIN3B 23 0.69 12.52 13.78 5.00
133 INT18012 Gene_expression of EPO 169 0.78 108.36 13.75 5.00
134 INT56651 Binding of HLA-DRB1 58 0.48 52.25 13.68 5.00
135 INT33358 Gene_expression of Cysltr1 46 0.62 24.18 13.36 5.00
136 INT86383 Negative_regulation of EGFR 258 0.59 173.94 13.32 5.00
137 INT122812 Gene_expression of SNRNP70 130 0.75 67 12.5 5.00
138 INT22030 Negative_regulation of Cysltr1 31 0.39 21.83 12.49 5.00
139 INT148207 Gene_expression of CTLA4 53 0.77 29.13 12.07 5.00
140 INT159127 Gene_expression of Nps 49 0.75 16.91 12.06 5.00
141 INT93715 Negative_regulation of MMP9 69 0.55 36.05 11.73 5.00
142 INT1735 Gene_expression of HSD11B1 199 0.75 257.87 11.5 5.00
143 INT661 Gene_expression of REN 100 0.78 48.21 11.36 5.00
144 INT79656 Positive_regulation of NR3C1 14 0.68 6.38 10.83 5.00
145 INT111335 Gene_expression of HSPD1 57 0.75 55.51 10.38 5.00
146 INT145875 Gene_expression of Grm2 28 0.58 6.81 10.19 5.00
147 INT5788 Gene_expression of IL2RA 60 0.75 40.67 9.98 5.00
148 INT180163 Positive_regulation of Nfasc 49 0.40 31.96 9.41 5.00
149 INT64346 Positive_regulation of S100B 95 0.70 63.11 9.17 5.00
150 INT48978 Negative_regulation of FOS 41 0.57 11.94 9.14 5.00
151 INT51165 Binding of Gal 10 0.48 2.56 8.41 5.00
152 INT169015 Gene_expression of FOXP3 50 0.60 33.18 8.4 5.00
153 INT146343 Regulation of Slc6a3 17 0.60 7.33 8.27 5.00
154 INT63401 Gene_expression of Il5 33 0.72 18.66 8.2 5.00
155 INT69460 Positive_regulation of Grm2 12 0.49 6.54 8.18 5.00
156 INT132278 Binding of CTLA4 32 0.39 18.69 8.17 5.00
157 INT112104 Binding of Grin2b 21 0.44 6.78 8.16 5.00
158 INT86411 Negative_regulation of Negative_regulation of TNF 24 0.42 17.6 7.89 5.00
159 INT177759 Negative_regulation of IFN1@ 51 0.57 31.81 7.76 5.00
160 INT17501 Negative_regulation of F2 70 0.58 32.23 7.51 5.00
161 INT101121 Regulation of Comt 19 0.53 10.66 7.22 5.00
162 INT35584 Binding of ACLY 22 0.35 31.78 7.17 5.00
163 INT93003 Binding of CD40 28 0.47 20.25 7.13 5.00
164 INT1124 Negative_regulation of CD40LG 53 0.57 36.26 7 5.00
165 INT1973 Positive_regulation of NAGLU 36 0.65 14.78 7 5.00
166 INT11747 Positive_regulation of IL2RA 22 0.67 16.55 6.95 5.00
167 INT95117 Gene_expression of PDGFA 71 0.71 51.17 6.9 5.00
168 INT2111 Gene_expression of LIF 34 0.77 16.82 6.76 5.00
169 INT8101 Binding of INCENP 42 0.31 16.2 6.68 5.00
170 INT73499 Positive_regulation of IL13 23 0.39 20.03 6.53 5.00
171 INT83451 Positive_regulation of Gene_expression of CD40LG 26 0.60 22.81 6.25 5.00
172 INT8683 Positive_regulation of F3 31 0.67 42.89 6.21 5.00
173 INT57562 Gene_expression of GLA 52 0.77 24.62 6.14 5.00
174 INT4144 Gene_expression of SHBG 64 0.68 39.94 6.08 5.00
175 INT188844 Gene_expression of AES 44 0.58 33.94 5.85 5.00
176 INT65150 Gene_expression of Drb1 10 0.44 12.97 5.82 5.00
177 INT69153 Positive_regulation of Gene_expression of IL5 22 0.32 23.59 5.7 5.00
178 INT103260 Positive_regulation of Nps 35 0.48 23.8 5.67 5.00
179 INT148968 Gene_expression of Gpbar1 29 0.56 11.9 5.66 5.00
180 INT45753 Localization of CD40LG 45 0.79 32.31 5.28 5.00
181 INT19271 Binding of Aap 6 0.30 0.88 5.27 5.00
182 INT3550 Negative_regulation of GLA 52 0.59 33.93 5.26 5.00
183 INT107386 Negative_regulation of AGTR1 37 0.55 35.94 5.15 5.00
184 INT10605 Positive_regulation of Ltc4s 21 0.68 17.22 4.8 5.00
185 INT4146 Binding of SHBG 49 0.47 31 4.71 5.00
186 INT4679 Negative_regulation of RAPGEF5 55 0.57 47.51 4.55 5.00
187 INT102187 Gene_expression of SH2B2 23 0.59 26.54 4.39 5.00
188 INT322999 Binding of SSD 10 0.39 3.86 4.28 5.00
189 INT9098 Positive_regulation of DBP 30 0.69 15.77 4.26 5.00
190 INT5219 Negative_regulation of DBP 43 0.57 23.35 4.26 5.00
191 INT85677 Positive_regulation of Gpbar1 24 0.68 8.41 4.09 5.00
192 INT104221 Regulation of Gene_expression of CRP 30 0.45 20.01 4.07 5.00
193 INT172197 Positive_regulation of Gene_expression of Comt 12 0.69 7.61 4.06 5.00
194 INT120810 Binding of Dlg4 38 0.41 3.55 4.03 5.00
195 INT183207 Negative_regulation of USE1 14 0.18 10.97 4 5.00
196 INT269961 Gene_expression of Hoxb8 3 0.69 14.28 3.91 5.00
197 INT92653 Gene_expression of IL12B 21 0.75 17.28 3.89 5.00
198 INT20743 Positive_regulation of Gene_expression of Ltc4s 13 0.60 12.3 3.86 5.00
199 INT34720 Positive_regulation of SHBG 58 0.69 32.4 3.83 5.00
200 INT44254 Regulation of Gene_expression of ALOX5 12 0.43 7.06 3.65 5.00
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