D:Rickettsiaceae Infection

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Disease Term
Synonyms Apanese River Fever, BRILL ZINSESER DISEASE, CRUB MITE BORNE TYPHUS, Crub Typhus Disorder, Disease Caused By Rickettsia, Eastern Tick Borne Rickettsioises, Edani Fever, Epidemic Typhus, Ickettsia Tsutsugamushi Infection, Infection Rickettsiaceae, INFECTIONS RICKETTSIACEAE
Documents 247
Hot Single Events 73
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Rickettsiaceae Infection. They are ordered first by their relevance to Rickettsiaceae Infection and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT308896 Binding of Babr and Lmrq1 1 0.01 1.24 0 74.72
2 INT323332 Binding of Ighm and Chd7 1 0.02 0 0 50.00
3 INT323333 Binding of Ighm and Ict1 1 0.02 0 0 50.00
4 INT208461 Binding of CD4 and IL16 1 0.05 3.04 0.41 5.00
5 INT310255 Tlr4 Positive_regulation of Gene_expression of Cd86 2 0.18 0.06 0.27 5.00
6 INT347012 Hand2 Positive_regulation of Il4 1 0.01 0 0.14 5.00
7 INT347015 Hand2 Regulation of Cd86 1 0.06 0 0.14 5.00
8 INT347018 Cd80 Regulation of Hand2 1 0.03 0.05 0.13 5.00
9 INT347019 Cd80 Regulation of Hand1 1 0.01 0.05 0.13 5.00
10 INT347007 Cd86 Regulation of Hand2 1 0.06 0.05 0.13 5.00
11 INT347014 Cd86 Regulation of Hand1 1 0.02 0.05 0.13 5.00
12 INT347017 Cd86 Positive_regulation of Gene_expression of Il4 1 0.03 0 0.13 5.00
13 INT347006 Tlr4 Positive_regulation of Cd86 1 0.17 0 0.09 5.00
14 INT347021 Cd86 Positive_regulation of Gene_expression of IGHE 1 0.03 0.18 0.05 5.00
15 INT347011 Negative_regulation of Mdk Negative_regulation of Regulation of Cd86 1 0.05 0 0.04 5.00
16 INT319111 Binding of Yy1 and Sap30 1 0.01 0 0.04 5.00
17 INT347016 Cd86 Regulation of Gene_expression of Il4 1 0.03 0.19 0.04 5.00
18 INT347020 Hand2 Regulation of Gene_expression of Cd86 1 0.08 0.19 0.04 5.00
19 INT347009 Hand2 Regulation of Gene_expression of Il4 1 0.01 0.19 0.04 5.00
20 INT347013 Il4 Regulation of Gene_expression of Cd86 1 0.02 0.07 0 5.00
21 INT319094 Binding of polymerase and RNPC3 1 0.00 0.13 0 5.00
22 INT347008 Tlr4 Positive_regulation of Phosphorylation of Mapk14 1 0.02 0.06 0 5.00
23 INT176919 Binding of DLD and Bpifa2 1 0.00 0.08 0 5.00
24 INT176920 DLD Positive_regulation of Binding of Bpifa2 1 0.00 0.08 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Rickettsiaceae Infection. They are ordered first by their pain relevance and then by number of times they were reported in Rickettsiaceae Infection. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT3796 Gene_expression of Ighm 130 0.77 69.61 13.78 100.00
2 INT199208 Gene_expression of Ict1 7 0.08 3.92 0.08 100.00
3 INT39301 Gene_expression of Chd7 50 0.26 27.06 8.13 100.00
4 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 99.98
5 INT9852 Positive_regulation of Gpt 563 0.70 364.64 146.82 99.98
6 INT76924 Positive_regulation of Slc17a5 71 0.70 41.21 19.31 99.98
7 INT20205 Binding of IgG 108 0.46 66.68 8.57 99.64
8 INT350311 Positive_regulation of Gene_expression of Gspt1 1 0.05 1.09 0 99.62
9 INT3952 Negative_regulation of ALB 116 0.59 72.18 18.35 99.58
10 INT35460 Gene_expression of IL16 45 0.75 48.71 10.5 99.56
11 INT303530 Gene_expression of Gspt1 2 0.07 1.23 0.1 99.38
12 INT10019 Binding of CD8A 57 0.36 31.49 10.08 99.36
13 INT47805 Positive_regulation of Gspt1 5 0.11 1.02 0.47 99.20
14 INT145266 Gene_expression of IL17A 154 0.75 109.83 45.33 98.80
15 INT9408 Positive_regulation of Crp 296 0.69 242.27 57.35 98.76
16 INT546 Binding of ALB 311 0.48 85.98 60.14 98.68
17 INT35461 Positive_regulation of Gene_expression of IL16 22 0.67 25.57 4.24 98.64
18 INT208467 Positive_regulation of IL16 31 0.67 40.09 2.56 98.64
19 INT3760 Positive_regulation of ALB 142 0.70 87.46 26.7 98.46
20 INT47804 Negative_regulation of Gspt1 3 0.29 1.94 2.04 98.00
21 INT45753 Localization of CD40LG 45 0.79 32.31 5.28 98.00
22 INT67981 Positive_regulation of CCL2 165 0.70 136.84 61.85 97.88
23 INT62868 Gene_expression of Ifna 15 0.67 5.37 0.51 97.76
24 INT12265 Positive_regulation of IgG 168 0.63 104.89 19.76 97.66
25 INT1125 Positive_regulation of IGHG3 130 0.69 112.07 13.18 97.60
26 INT3361 Positive_regulation of Esr1 273 0.69 208.53 44.81 97.24
27 INT11560 Positive_regulation of CASP3 236 0.70 184.33 39.38 97.04
28 INT75540 Positive_regulation of TH1L 62 0.67 43.45 15.02 96.88
29 INT108588 Gene_expression of CASP3 126 0.78 84.49 16.2 96.64
30 INT284 Positive_regulation of Ggt6 18 0.67 13.56 4.62 96.24
31 INT22019 Regulation of GHR 9 0.62 2.56 2.39 96.24
32 INT22020 Regulation of Positive_regulation of GHR 1 0.39 1.03 0.14 96.24
33 INT30738 Negative_regulation of Gene_expression of ALB 32 0.59 19.01 5.04 95.96
34 INT4509 Gene_expression of IgG 426 0.76 293.69 56.64 95.28
35 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 95.04
36 INT199209 Regulation of Ict1 4 0.05 2.53 0.03 94.64
37 INT56785 Positive_regulation of SP110 2 0.54 3.85 0.3 94.48
38 INT5148 Regulation of CD40LG 25 0.44 21.58 4.05 94.08
39 INT214514 Gene_expression of SP110 1 0.77 5.65 0 93.60
40 INT3795 Positive_regulation of Ighm 46 0.68 22.43 6.47 92.72
41 INT16286 Positive_regulation of GHR 8 0.60 4.04 2.31 92.68
42 INT61501 Transcription of FN1 6 0.68 4.6 0.39 92.16
43 INT16996 Gene_expression of PRTN3 113 0.75 85.61 22.57 91.96
44 INT71918 Gene_expression of ACTA1 16 0.75 7.73 1.45 91.12
45 INT181637 Gene_expression of CMA1 10 0.66 4.16 0.72 90.76
46 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 88.56
47 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 88.56
48 INT11051 Positive_regulation of Gene_expression of IL6 415 0.69 319.21 109.3 88.56
49 INT57201 Localization of ACTA1 2 0.73 1.53 0.56 87.48
50 INT194298 Gene_expression of DHPS 1 0.62 8.84 0.37 87.44
51 INT4216 Gene_expression of CD40LG 328 0.78 256.02 44.23 86.56
52 INT14737 Gene_expression of FN1 117 0.78 78.74 18.99 86.16
53 INT57273 Positive_regulation of Gene_expression of FN1 26 0.47 17.83 4.2 86.16
54 INT20207 Binding of Ighm 14 0.46 2.88 1.79 86.00
55 INT46637 Gene_expression of CXCL10 172 0.78 121.94 57.74 85.08
56 INT94335 Positive_regulation of CXCL10 71 0.58 50.69 23 85.08
57 INT92237 Positive_regulation of Gene_expression of CXCL10 43 0.70 43.67 13.65 85.08
58 INT9256 Gene_expression of SELPLG 30 0.75 16.44 3.66 85.00
59 INT173851 Localization of FN1 20 0.76 13.95 1.97 84.80
60 INT55879 Gene_expression of CCL2 421 0.78 240.74 166.02 84.68
61 INT81498 Positive_regulation of Gene_expression of CCL2 107 0.70 53.89 45.22 84.68
62 INT17564 Gene_expression of Gpt 322 0.75 208.51 60.36 83.80
63 INT14732 Positive_regulation of FN1 46 0.69 31.17 7.33 83.68
64 INT318974 Gene_expression of Zc3hav1 1 0.01 3.67 0.09 83.36
65 INT58288 Positive_regulation of Gene_expression of Crp 83 0.61 82.23 23.7 83.00
66 INT15516 Gene_expression of Crp 711 0.77 615.33 173.09 83.00
67 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 83.00
68 INT12035 Regulation of F2 21 0.45 12.66 1.47 82.88
69 INT46087 Regulation of F3 4 0.45 3.49 0.68 82.88
70 INT89935 Regulation of SERPINC1 5 0.37 5.11 0.41 82.88
71 INT725 Negative_regulation of IgG 62 0.41 37.21 8.16 82.48
72 INT8683 Positive_regulation of F3 31 0.67 42.89 6.21 81.48
73 INT11710 Positive_regulation of SERPINC1 6 0.59 6.15 1.47 81.48
74 INT16349 Positive_regulation of alp 25 0.60 16.74 4.34 79.48
75 INT846 Positive_regulation of B2M 42 0.70 29.78 8.06 78.08
76 INT10612 Localization of NLRP3 13 0.78 8.91 2.27 77.92
77 INT257406 Localization of TNFRSF1A 3 0.46 2.6 0.55 77.92
78 INT257407 Localization of MVK 1 0.22 1.78 0.18 77.92
79 INT255650 Phosphorylation of FN1 1 0.52 2.58 0 77.68
80 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 77.68
81 INT80005 Gene_expression of MVK 4 0.09 1.79 1.34 77.48
82 INT284164 Localization of Chd7 3 0.25 1.32 0.41 77.44
83 INT140063 Binding of IDH2 2 0.32 1.35 0.19 77.40
84 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 77.28
85 INT15132 Gene_expression of TNFRSF1A 33 0.75 20.09 5.93 77.28
86 INT23174 Gene_expression of NLRP3 51 0.72 35.49 6.47 76.72
87 INT258462 Localization of Ict1 2 0.09 0.74 0 76.56
88 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 76.32
89 INT1705 Gene_expression of pCA 126 0.65 88.65 34.81 74.96
90 INT4498 Gene_expression of F2 83 0.65 57.4 10.8 74.52
91 INT327085 Regulation of RNR1 1 0.00 0.68 0.06 74.04
92 INT4004 Gene_expression of IGHG3 321 0.71 221.03 42.33 73.96
93 INT61500 Binding of FN1 39 0.48 27.33 3.13 73.72
94 INT37912 Negative_regulation of Chd7 10 0.26 5.84 4.46 73.36
95 INT45818 Gene_expression of C4A 35 0.75 26.4 3.52 73.12
96 INT331308 Gene_expression of PLEKHG4 1 0.15 0.81 0 72.92
97 INT331307 Negative_regulation of Gene_expression of PLEKHG4 1 0.10 0.87 0 72.92
98 INT199206 Negative_regulation of Ict1 9 0.05 3.67 0.21 72.48
99 INT100698 Regulation of Chd7 6 0.34 1.85 0.49 67.68
100 INT255213 Gene_expression of DUH 1 0.06 0.68 0 65.04
101 INT285 Positive_regulation of Salpa1 73 0.68 61.47 9.19 64.12
102 INT242263 Regulation of ACAT1 4 0.09 0.66 0.1 60.64
103 INT17110 Gene_expression of PSMD1 60 0.65 19.57 4.69 59.24
104 INT106745 Localization of CRP 65 0.81 66.44 15.21 50.00
105 INT11788 Positive_regulation of Rrsv 36 0.46 10.08 9.68 50.00
106 INT15999 Regulation of Rrsv 14 0.23 6.06 7.48 50.00
107 INT77852 Binding of Chd7 8 0.31 4.1 2.51 50.00
108 INT3797 Positive_regulation of Gene_expression of Ighm 16 0.47 9.4 2.01 50.00
109 INT80798 Positive_regulation of Chd7 16 0.14 7.95 1.95 50.00
110 INT61076 Gene_expression of RHD 9 0.65 3.52 1.39 50.00
111 INT81934 Gene_expression of Il4i1 4 0.22 1.91 0.65 50.00
112 INT255212 Localization of IRS4 1 0.08 0.93 0.08 50.00
113 INT255215 Gene_expression of IRS4 1 0.19 0.92 0.08 50.00
114 INT323331 Binding of Ict1 1 0.02 0 0 50.00
115 INT255214 Gene_expression of RPA4 1 0.11 1.26 0 50.00
116 INT258461 Positive_regulation of Ict1 3 0.06 0.37 0 50.00
117 INT84080 Localization of MDH2 2 0.55 0.57 0.45 49.16
118 INT108902 Localization of GNAS 5 0.13 1.31 0.23 49.16
119 INT131378 Negative_regulation of FN1 20 0.35 33.98 5.85 42.48
120 INT214515 Regulation of Transcription of SELPLG 1 0.09 0.16 0 42.08
121 INT214518 Regulation of Transcription of SP110 1 0.61 1.02 0 42.08
122 INT214516 Transcription of SP110 1 0.72 2.5 0 40.80
123 INT214512 Transcription of SELPLG 1 0.14 0.16 0 40.80
124 INT214517 Positive_regulation of Transcription of SP110 1 0.47 1.45 0 39.92
125 INT52264 Gene_expression of IK 180 0.77 90.87 51.87 37.12
126 INT296992 Gene_expression of MLST8 19 0.07 18.39 0.73 33.00
127 INT214519 Positive_regulation of Gene_expression of SP110 1 0.50 1.18 0 30.72
128 INT102845 Localization of CASP3 7 0.81 2.81 1.06 28.08
129 INT208466 Positive_regulation of Localization of CASP3 1 0.01 0.98 0 28.08
130 INT4420 Positive_regulation of GOT1 103 0.64 88.4 18.38 25.00
131 INT59194 Gene_expression of STS 18 0.59 6.74 1.89 21.80
132 INT214513 Negative_regulation of Gene_expression of SP110 1 0.43 0.46 0 21.80
133 INT32933 Gene_expression of GNAS 57 0.32 10.58 4.03 7.92
134 INT867 Gene_expression of IFNA1 930 0.78 594.85 168.03 5.00
135 INT9660 Regulation of TNF 363 0.62 312.94 139.99 5.00
136 INT7533 Gene_expression of Tlr4 720 0.78 343.22 121.57 5.00
137 INT20374 Gene_expression of Il4 515 0.76 306.15 114.12 5.00
138 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 5.00
139 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 5.00
140 INT92434 Phosphorylation of Mapk1 287 0.82 91.65 83.46 5.00
141 INT1498 Gene_expression of Gh 521 0.75 220.84 81.16 5.00
142 INT13276 Regulation of Ltp 107 0.53 30.78 69.13 5.00
143 INT3375 Gene_expression of IGHE 535 0.77 387.47 65.46 5.00
144 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64 5.00
145 INT1951 Positive_regulation of Tlr4 345 0.70 176.99 62.42 5.00
146 INT5058 Positive_regulation of IFNA1 356 0.70 245.75 60.52 5.00
147 INT96914 Phosphorylation of Mapk14 168 0.82 108.46 53.32 5.00
148 INT20382 Gene_expression of Hand2 211 0.66 142.26 51.05 5.00
149 INT7093 Negative_regulation of CYP2B6 146 0.58 37.3 48.39 5.00
150 INT20492 Gene_expression of MMP12 89 0.76 81.36 46.12 5.00
151 INT3987 Positive_regulation of IGHE 316 0.70 283.2 40.16 5.00
152 INT70437 Negative_regulation of Mdk 115 0.57 41.03 35.72 5.00
153 INT13186 Positive_regulation of Il4 113 0.68 71.22 31.4 5.00
154 INT56809 Binding of Tlr4 184 0.48 106.02 31.18 5.00
155 INT54302 Positive_regulation of Gene_expression of Il4 126 0.68 86.18 30.75 5.00
156 INT90792 Localization of Il10 144 0.80 87.88 30.03 5.00
157 INT21900 Gene_expression of Mthfd1 150 0.75 69.47 27.03 5.00
158 INT100861 Binding of CRP 179 0.48 175.2 26.45 5.00
159 INT20462 Binding of ESR1 210 0.44 102.7 26.34 5.00
160 INT2040 Positive_regulation of CYP2B6 95 0.69 34.3 25.6 5.00
161 INT55583 Localization of IFNA1 135 0.78 85.07 24.13 5.00
162 INT4781 Gene_expression of TH 68 0.73 26.92 24.01 5.00
163 INT134651 Binding of TLR4 89 0.48 66.96 23.19 5.00
164 INT84732 Positive_regulation of Hand2 81 0.69 62.07 22 5.00
165 INT96156 Gene_expression of Cd40 144 0.77 56.95 21.7 5.00
166 INT7535 Negative_regulation of Tlr4 111 0.56 56.84 21.37 5.00
167 INT14701 Negative_regulation of IFNA1 118 0.54 84.19 20.08 5.00
168 INT73252 Positive_regulation of Mthfd1 124 0.59 59.48 18.35 5.00
169 INT112017 Regulation of Hand2 77 0.36 62.23 18.04 5.00
170 INT23635 Positive_regulation of MMP12 31 0.59 28.19 17.95 5.00
171 INT111531 Negative_regulation of Phosphorylation of Mapk14 37 0.50 20 17.68 5.00
172 INT96155 Gene_expression of Cd86 134 0.77 50.56 17.13 5.00
173 INT104045 Regulation of Hand1 65 0.35 51.32 16.26 5.00
174 INT98647 Positive_regulation of Mdk 65 0.59 32.93 15.67 5.00
175 INT111462 Negative_regulation of Phosphorylation of Mapk1 45 0.57 19.49 15.59 5.00
176 INT69952 Positive_regulation of IK 45 0.32 16.08 14.59 5.00
177 INT13752 Binding of Scn4a 24 0.36 5.68 14.16 5.00
178 INT120828 Localization of CXCL10 29 0.68 18.01 12.17 5.00
179 INT96157 Gene_expression of Cd80 74 0.77 31.19 9.78 5.00
180 INT15722 Positive_regulation of PPAP2A 25 0.43 4.83 9.65 5.00
181 INT3988 Positive_regulation of Gene_expression of IGHE 98 0.68 91.46 9.61 5.00
182 INT69264 Gene_expression of KIT 207 0.78 179.41 8.95 5.00
183 INT79693 Regulation of Il4 30 0.51 21.96 8.6 5.00
184 INT75841 Binding of Trav6-3 66 0.47 29.14 7.63 5.00
185 INT18524 Regulation of Gene_expression of IFNA1 37 0.44 18.79 7.62 5.00
186 INT1952 Negative_regulation of Positive_regulation of Tlr4 33 0.51 15.8 7.41 5.00
187 INT44920 Negative_regulation of IK 18 0.41 9.9 7.16 5.00
188 INT93046 Positive_regulation of Gene_expression of Hand2 27 0.47 24.54 7.01 5.00
189 INT125143 Gene_expression of EPHB2 40 0.71 13.27 6.97 5.00
190 INT35462 Negative_regulation of Gene_expression of IL16 9 0.53 2.04 6.83 5.00
191 INT160562 Localization of Cd4 49 0.71 27.58 6.78 5.00
192 INT56149 Localization of CD8A 56 0.74 30.41 5.75 5.00
193 INT6601 Gene_expression of PPAP2A 21 0.27 3.13 5.52 5.00
194 INT142607 Positive_regulation of Gene_expression of Cd40 41 0.62 13.85 5.51 5.00
195 INT12324 Positive_regulation of PRTN3 26 0.70 18.82 4.55 5.00
196 INT135990 Positive_regulation of Gene_expression of Cd86 34 0.69 12.02 4.53 5.00
197 INT108342 Negative_regulation of EPHB2 18 0.57 9.48 4.46 5.00
198 INT35765 Gene_expression of TXNRD1 47 0.56 9.16 4.43 5.00
199 INT20372 Localization of Il5 26 0.41 18.33 4.27 5.00
200 INT2723 Gene_expression of Salpa1 16 0.64 11.78 3.5 5.00
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