D:Rod Or Cone Dystrophy

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Disease Term
Synonyms Cone Dystrophy, Rod Dystrophy
Documents 15
Hot Single Events 9
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Rod Or Cone Dystrophy. They are ordered first by their relevance to Rod Or Cone Dystrophy and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT306339 Binding of CRX and PAX6 1 0.53 0.27 0 75.04
2 INT315030 Binding of Cav1 and Tmie 1 0.03 0.25 0.14 5.00
3 INT315032 Binding of Cav1 and Ryr1 1 0.27 0.2 0.14 5.00
4 INT236531 Binding of Cacna1f and Flna 1 0.08 0 0.07 5.00
5 INT339583 Binding of ABCA1 and RPE 1 0.03 1.38 0.05 5.00
6 INT339587 Positive_regulation of Binding of ABCA1 and RPE 1 0.04 1.38 0.05 5.00
7 INT315034 Ass1 Positive_regulation of Cacna1f 1 0.00 0 0.03 5.00
8 INT339582 AMD1 Regulation of C1QTNF5 1 0.07 2 0 5.00
9 INT277555 Clrn1 Regulation of Localization of Pdc 1 0.05 0.7 0 5.00
10 INT315033 Binding of Calm3 and Vsig2 1 0.00 0 0 5.00
11 INT236528 Binding of Cav1 and Flna 1 0.06 0.09 0 5.00
12 INT339581 Binding of TIMP1 and TIMP3 1 0.30 0.54 0 5.00
13 INT338162 Positive_regulation of Binding of YWHAQ and Nxnl1 1 0.49 0.26 0 5.00
14 INT227399 Binding of D5Mit424 and Alms1 1 0.01 0.71 0 5.00
15 INT315029 Binding of Calm3 and Cacna1f 1 0.04 0 0 5.00
16 INT339580 TIMP3 Positive_regulation of ABCA1 1 0.16 0.73 0 5.00
17 INT339585 Binding of AMD1 and MDM1 1 0.06 2.02 0 5.00
18 INT315035 Binding of NAE1 and Cav1 1 0.01 0.7 0 5.00
19 INT339586 TIMP3 Positive_regulation of RPE 1 0.16 0.72 0 5.00
20 INT236529 Binding of Om and Flna 1 0.00 0.09 0 5.00
21 INT315031 Binding of Cacna1f and Vsig2 1 0.02 0 0 5.00
22 INT227398 Binding of H2afy and Alms1 1 0.01 1.42 0 5.00
23 INT338161 Binding of YWHAQ and Nxnl1 1 0.37 0.26 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Rod Or Cone Dystrophy. They are ordered first by their pain relevance and then by number of times they were reported in Rod Or Cone Dystrophy. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT287345 Positive_regulation of CORD1 1 0.26 0.71 0 100.00
2 INT277542 Negative_regulation of Pdc 1 0.03 1.61 0 99.44
3 INT186637 Regulation of ABCA4 3 0.37 2.02 0.07 92.56
4 INT186641 Localization of SYT4 1 0.33 0.28 0.32 88.24
5 INT186647 Localization of SYN2 1 0.34 0.28 0.32 87.76
6 INT115303 Localization of SNAP25 8 0.73 1.43 1.82 87.28
7 INT186650 Localization of VAMP2 1 0.40 0.39 0.38 87.28
8 INT315026 Gene_expression of Csn2 1 0.30 0.24 0.12 86.20
9 INT236516 Regulation of Cacna1f 3 0.44 0.23 0 84.48
10 INT173878 Gene_expression of ACAN 32 0.75 9.35 3.55 79.72
11 INT277526 Gene_expression of Clrn1 1 0.78 29.02 0.17 79.28
12 INT115659 Gene_expression of ABCB6 29 0.75 13.59 1.43 73.84
13 INT112089 Gene_expression of Cav1 73 0.75 23.8 1.97 73.36
14 INT236517 Gene_expression of Cacna1f 8 0.65 5.18 0.77 72.60
15 INT24519 Negative_regulation of ERG 15 0.38 6.98 1.33 67.04
16 INT24225 Gene_expression of Alms1 93 0.62 52.75 16.93 65.24
17 INT108761 Localization of Alms1 24 0.70 13.92 3.74 65.24
18 INT15459 Gene_expression of TRH 17 0.78 4.89 8.17 64.04
19 INT262546 Positive_regulation of Binding of Calm3 2 0.11 0.3 0.39 62.68
20 INT134864 Binding of Calm3 20 0.27 1.86 6.86 62.16
21 INT216380 Gene_expression of PAX6 49 0.78 15.63 1.22 53.52
22 INT287346 Negative_regulation of CORD1 2 0.24 0.4 0.27 50.00
23 INT287344 Regulation of NDUFB11 1 0.01 0.33 0 50.00
24 INT206982 Negative_regulation of TDO2 2 0.19 1.51 0 43.12
25 INT181614 Positive_regulation of TDO2 2 0.45 2.18 0.18 38.28
26 INT102839 Gene_expression of Pdc 15 0.52 6.3 1.87 33.60
27 INT36453 Binding of ABCA1 48 0.45 19.9 10.84 28.68
28 INT170444 Binding of Gopc 172 0.39 45.05 20.71 23.00
29 INT186661 Regulation of ARR3 1 0.13 0.07 0 19.28
30 INT186653 Regulation of SAG 1 0.06 0.07 0 19.28
31 INT109124 Positive_regulation of TIMP3 8 0.61 5.57 5.72 17.76
32 INT186652 Gene_expression of SAG 1 0.14 0.07 0 16.96
33 INT134175 Gene_expression of ARR3 2 0.29 0.36 0.19 16.76
34 INT206980 Gene_expression of Ambn 1 0.50 1.96 0.03 10.16
35 INT315024 Positive_regulation of Cacna1f 1 0.41 0.5 0.17 9.52
36 INT161027 Negative_regulation of RPE 7 0.37 4.34 0.38 9.04
37 INT5379 Gene_expression of Fos 656 0.78 255.5 292.54 5.00
38 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 5.00
39 INT5380 Positive_regulation of Gene_expression of Fos 243 0.70 105.65 131.05 5.00
40 INT85640 Gene_expression of Tg(CAG-EGFP)D4Nagy 1138 0.72 311.58 119.18 5.00
41 INT7944 Positive_regulation of Fos 193 0.70 60.69 98.31 5.00
42 INT3537 Positive_regulation of Car2 413 0.56 103.51 94.35 5.00
43 INT11318 Gene_expression of Gtf3a 274 0.52 183.82 60.89 5.00
44 INT169926 Positive_regulation of Gopc 416 0.46 157.8 58.67 5.00
45 INT8528 Negative_regulation of Gene_expression of Fos 100 0.59 41.15 55.6 5.00
46 INT111051 Negative_regulation of Nav1 64 0.59 25.51 47.27 5.00
47 INT30170 Gene_expression of Car2 330 0.66 77.26 46.76 5.00
48 INT17561 Localization of Car2 303 0.79 60.95 44.52 5.00
49 INT170054 Negative_regulation of Gopc 280 0.38 117.89 42.4 5.00
50 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 5.00
51 INT666 Gene_expression of Jun 124 0.78 54.61 33.67 5.00
52 INT11014 Phosphorylation of CREB1 72 0.81 26.35 25.64 5.00
53 INT111401 Positive_regulation of Gene_expression of Tg(CAG-EGFP)D4Nagy 134 0.61 34.87 20.15 5.00
54 INT170051 Positive_regulation of Gene_expression of Gopc 150 0.43 56.75 16.93 5.00
55 INT69769 Positive_regulation of Pscs 61 0.56 39.32 15.93 5.00
56 INT20420 Gene_expression of MYC 99 0.75 49.32 14.36 5.00
57 INT11696 Gene_expression of HLA-A 50 0.78 41.25 14.1 5.00
58 INT67653 Gene_expression of Om 46 0.36 15.28 13.32 5.00
59 INT14510 Gene_expression of SOD1 208 0.76 88.56 12.4 5.00
60 INT55687 Localization of TIMP1 47 0.74 30.24 12.31 5.00
61 INT25963 Gene_expression of DES 122 0.75 98.81 11.25 5.00
62 INT25170 Positive_regulation of Localization of Car2 78 0.67 15.25 11.24 5.00
63 INT111992 Gene_expression of Pscs 40 0.76 27.47 10.74 5.00
64 INT82769 Positive_regulation of Grm1 20 0.00 7.78 9.82 5.00
65 INT28312 Gene_expression of ABCA1 85 0.72 37.69 9.27 5.00
66 INT13010 Gene_expression of TYR 38 0.65 14.81 8.84 5.00
67 INT170504 Positive_regulation of Gene_expression of Car2 60 0.41 19.1 8.45 5.00
68 INT18185 Gene_expression of Tyr 32 0.76 12.52 8.17 5.00
69 INT156396 Localization of Tg(CAG-EGFP)D4Nagy 61 0.55 13.63 8.17 5.00
70 INT87271 Positive_regulation of Phosphorylation of CREB1 27 0.66 12.87 7.91 5.00
71 INT64816 Transcription of Jun 31 0.69 16.01 7.64 5.00
72 INT155680 Gene_expression of Slc1a3 22 0.66 6.76 7.23 5.00
73 INT14637 Negative_regulation of MBP 19 0.43 7.06 7.18 5.00
74 INT39516 Gene_expression of Alb 81 0.75 30.08 6.59 5.00
75 INT94649 Gene_expression of Grm1 19 0.77 5.11 6.58 5.00
76 INT186623 Negative_regulation of Mag 13 0.42 12.22 6.48 5.00
77 INT11258 Gene_expression of Gnas 58 0.58 21.6 6.33 5.00
78 INT67635 Negative_regulation of Gnas 29 0.04 11.4 6.32 5.00
79 INT49027 Gene_expression of TYRP1 35 0.75 9.81 6.06 5.00
80 INT26585 Gene_expression of Vim 117 0.77 39.97 6 5.00
81 INT131378 Negative_regulation of FN1 20 0.35 33.98 5.85 5.00
82 INT18681 Gene_expression of Thy1 80 0.71 38.8 5.23 5.00
83 INT80038 Positive_regulation of Gene_expression of MYC 24 0.67 13.93 5.17 5.00
84 INT74051 Negative_regulation of Localization of Car2 27 0.38 9.58 5.1 5.00
85 INT44608 Gene_expression of C2 45 0.75 15.84 5.05 5.00
86 INT155681 Negative_regulation of Gene_expression of Slc1a3 5 0.36 2.26 4.86 5.00
87 INT72703 Gene_expression of Ide 79 0.70 45.04 4.47 5.00
88 INT47766 Transcription of Fos 25 0.69 8.78 4.42 5.00
89 INT154527 Gene_expression of POU5F1 180 0.78 34.01 4.34 5.00
90 INT4360 Gene_expression of Hypism 29 0.22 38.1 4.07 5.00
91 INT64163 Negative_regulation of Gene_expression of Jun 13 0.58 3.86 4.03 5.00
92 INT43931 Binding of CFH 49 0.48 31.85 3.96 5.00
93 INT170455 Gene_expression of Atp8a1 66 0.75 24.63 3.94 5.00
94 INT189629 Negative_regulation of TIMP3 14 0.48 7.63 3.91 5.00
95 INT14091 Binding of Vsig2 8 0.42 3.21 3.91 5.00
96 INT66585 Gene_expression of IER3 13 0.63 7.39 3.48 5.00
97 INT5286 Gene_expression of ANTXR2 46 0.75 21.06 3.41 5.00
98 INT18670 Negative_regulation of ABCA1 16 0.54 5.8 3.39 5.00
99 INT18396 Positive_regulation of Ryr1 10 0.58 2.45 3.38 5.00
100 INT78297 Gene_expression of CD59 31 0.72 24.11 3.18 5.00
101 INT27446 Negative_regulation of CTSA 11 0.57 5.58 3.08 5.00
102 INT92632 Gene_expression of Vsig2 48 0.50 19.93 3.04 5.00
103 INT30171 Gene_expression of Calm3 13 0.73 0.58 2.96 5.00
104 INT69768 Negative_regulation of Pscs 7 0.51 4.76 2.82 5.00
105 INT185898 Gene_expression of MMP10 8 0.49 5.36 2.68 5.00
106 INT50080 Binding of APOE 38 0.45 29.61 2.67 5.00
107 INT153492 Gene_expression of Gmcl1 44 0.65 15.77 2.56 5.00
108 INT131456 Negative_regulation of MMRN1 14 0.19 9.49 2.29 5.00
109 INT127756 Negative_regulation of Map2k1 10 0.41 6.69 2.04 5.00
110 INT104564 Gene_expression of Aqp3 8 0.65 4.92 1.99 5.00
111 INT173512 Positive_regulation of Gene_expression of Alms1 12 0.44 8.66 1.95 5.00
112 INT114734 Localization of ANTXR2 5 0.73 3.28 1.62 5.00
113 INT135955 Positive_regulation of Cav1 17 0.48 7.73 1.61 5.00
114 INT37037 Positive_regulation of ANTXR2 6 0.50 5.75 1.56 5.00
115 INT185649 Regulation of ERG 17 0.20 10.14 1.49 5.00
116 INT111996 Positive_regulation of Gene_expression of Pscs 8 0.34 4.37 1.42 5.00
117 INT22871 Gene_expression of ELN 30 0.68 14.86 1.33 5.00
118 INT282590 Positive_regulation of Gene_expression of POU5F1 40 0.70 8.42 1.32 5.00
119 INT260525 Gene_expression of AMD1 25 0.66 24.58 1.32 5.00
120 INT170507 Localization of Tmie 27 0.43 6.25 1.31 5.00
121 INT178795 Positive_regulation of Zmat3 8 0.04 5.31 1.28 5.00
122 INT209417 Gene_expression of ERG 21 0.20 6.69 1.26 5.00
123 INT143759 Gene_expression of SOX2 46 0.55 11.12 1.24 5.00
124 INT144843 Regulation of Gmcl1 5 0.37 2.76 1.15 5.00
125 INT147909 Gene_expression of Lpl 21 0.58 9.35 1.14 5.00
126 INT170511 Regulation of Localization of Car2 11 0.21 2.18 1.09 5.00
127 INT147336 Gene_expression of HLA-G 12 0.75 7.27 1.08 5.00
128 INT21546 Regulation of ABCA1 16 0.40 4.21 1.04 5.00
129 INT99767 Regulation of THBS1 18 0.42 11.51 1.03 5.00
130 INT128609 Gene_expression of C1S 18 0.75 17.36 0.98 5.00
131 INT198324 Gene_expression of Rn28s1 5 0.65 1.3 0.96 5.00
132 INT166715 Gene_expression of Sox9 16 0.65 6.39 0.92 5.00
133 INT116831 Binding of Ryr1 11 0.47 0.12 0.9 5.00
134 INT134753 Gene_expression of TIMP3 19 0.68 15.24 0.88 5.00
135 INT191831 Positive_regulation of Slc1a3 6 0.49 3.66 0.87 5.00
136 INT112090 Negative_regulation of Gene_expression of Cav1 8 0.57 3.5 0.78 5.00
137 INT45722 Negative_regulation of CFHR1 6 0.56 1.43 0.78 5.00
138 INT85168 Negative_regulation of Om 5 0.02 0.32 0.72 5.00
139 INT201216 Negative_regulation of LAMB2 6 0.04 3.75 0.71 5.00
140 INT200750 Gene_expression of Rho 19 0.65 6.52 0.69 5.00
141 INT2384 Regulation of CTSA 4 0.44 2.22 0.69 5.00
142 INT109925 Gene_expression of RPE 11 0.65 12.46 0.68 5.00
143 INT248968 Regulation of Csn2 2 0.20 0.09 0.68 5.00
144 INT257447 Binding of TBCE 4 0.08 4.68 0.66 5.00
145 INT170503 Positive_regulation of Localization of Tmie 11 0.29 3.27 0.61 5.00
146 INT197512 Gene_expression of ABCA4 19 0.75 7.08 0.57 5.00
147 INT202940 Binding of AMD1 13 0.41 16.43 0.56 5.00
148 INT109904 Localization of RPE 5 0.73 4.9 0.56 5.00
149 INT315028 Regulation of Cav2 2 0.43 0.86 0.54 5.00
150 INT141706 Localization of HLA-DRB1 9 0.75 4.87 0.48 5.00
151 INT109903 Positive_regulation of Gene_expression of RPE 3 0.49 0.59 0.46 5.00
152 INT220504 Positive_regulation of Gene_expression of Cav1 11 0.39 6.26 0.43 5.00
153 INT277529 Positive_regulation of Gmcl1 5 0.19 3.67 0.42 5.00
154 INT277550 Positive_regulation of Gm14374 2 0.49 1.5 0.42 5.00
155 INT94173 Positive_regulation of CTSA 3 0.53 3.22 0.4 5.00
156 INT220506 Binding of Cav1 13 0.45 5.46 0.38 5.00
157 INT315006 Regulation of Localization of Tmie 2 0.04 0.26 0.37 5.00
158 INT114313 Binding of RHO 7 0.36 1.45 0.36 5.00
159 INT226933 Gene_expression of Rhod 2 0.46 0.2 0.35 5.00
160 INT165400 Positive_regulation of TST 13 0.68 4.25 0.35 5.00
161 INT186622 Negative_regulation of Chol1 9 0.42 3.86 0.32 5.00
162 INT236527 Localization of Cacna2d1 2 0.41 0.45 0.31 5.00
163 INT315011 Gene_expression of Cacna1d 1 0.57 4.47 0.29 5.00
164 INT174519 Gene_expression of C1R 4 0.35 0.51 0.29 5.00
165 INT111676 Phosphorylation of MYH14 5 0.48 2.14 0.28 5.00
166 INT236513 Regulation of Cacna2d1 2 0.15 0.42 0.27 5.00
167 INT166753 Gene_expression of Cacna2d1 2 0.21 1.41 0.25 5.00
168 INT277530 Binding of Gmcl1 4 0.22 1.27 0.25 5.00
169 INT186629 Gene_expression of HLA-F 2 0.22 0.9 0.24 5.00
170 INT339593 Gene_expression of FBLN1 2 0.14 3.01 0.24 5.00
171 INT186656 Gene_expression of C1QA 1 0.48 0.35 0.23 5.00
172 INT112838 Gene_expression of PRDX6 2 0.19 0.54 0.23 5.00
173 INT186662 Gene_expression of C1QC 3 0.46 10.44 0.23 5.00
174 INT135956 Phosphorylation of Cav1 5 0.64 2.24 0.22 5.00
175 INT186624 Localization of Atp8a1 5 0.73 1.06 0.22 5.00
176 INT135954 Positive_regulation of Phosphorylation of Cav1 2 0.40 0.64 0.22 5.00
177 INT186628 Gene_expression of DCT 5 0.46 3.79 0.21 5.00
178 INT273279 Negative_regulation of Localization of Tmie 2 0.07 1.72 0.2 5.00
179 INT63067 Localization of MYC 13 0.78 6.93 0.19 5.00
180 INT328636 Localization of ERG 2 0.06 0.62 0.19 5.00
181 INT220497 Regulation of Gene_expression of Cav1 4 0.36 1.84 0.18 5.00
182 INT186648 Negative_regulation of OLIG2 1 0.23 0.75 0.18 5.00
183 INT186655 Negative_regulation of OLIG1 1 0.23 0.74 0.18 5.00
184 INT315025 Gene_expression of Cacna1s 3 0.48 2.3 0.18 5.00
185 INT208539 Positive_regulation of Gene_expression of Gnas 4 0.08 2.76 0.18 5.00
186 INT189564 Binding of TIMP3 4 0.31 2.45 0.17 5.00
187 INT230969 Negative_regulation of COL4A4 3 0.14 2.66 0.16 5.00
188 INT315022 Regulation of Cacna1d 1 0.20 0.32 0.16 5.00
189 INT227405 Localization of Pdc 4 0.32 2.87 0.15 5.00
190 INT145253 Negative_regulation of Cav1 9 0.46 3.02 0.15 5.00
191 INT228607 Negative_regulation of Gene_expression of ERG 2 0.03 1.1 0.15 5.00
192 INT109930 Positive_regulation of RPE 4 0.49 5.88 0.15 5.00
193 INT186632 Regulation of TWIST1 4 0.37 5.28 0.14 5.00
194 INT315023 Transcription of Cacna1d 1 0.50 0.26 0.13 5.00
195 INT186664 Localization of HLA-DRB4 2 0.16 1.89 0.13 5.00
196 INT186649 Localization of HLA-DRB5 1 0.02 0.3 0.13 5.00
197 INT186633 Localization of HLA-DPB1 1 0.32 0.3 0.13 5.00
198 INT214975 Localization of Cav1 7 0.75 2.7 0.13 5.00
199 INT315027 Positive_regulation of Gene_expression of Cacna1f 1 0.41 0.27 0.12 5.00
200 INT315018 Positive_regulation of Gene_expression of Csn2 1 0.22 0 0.12 5.00
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