D:Sciatic Neuropathy

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Disease Term
Synonyms Lesion Of Sciatic Nerve, Nerve Disease Sciatic, NERVE DISEASES SCIATIC, Nerve Lesion Sciatic, NERVE LESIONS SCIATIC, Nerve Palsies Sciatic, NERVE PALSY SCIATIC, Neuralgia Neuritides Sciatic Nerve, Neuralgia Neuritis Sciatic Nerve, NEURITIDES SCIATIC, Neuritis Sciatic
Documents 138
Hot Single Events 57
Hot Interactions 2

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Sciatic Neuropathy. They are ordered first by their relevance to Sciatic Neuropathy and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT224282 Binding of Bdnf and Il6 1 0.08 0.26 0.45 97.04
2 INT79759 Ngf Regulation of Il6 1 0.60 4.62 5.62 87.76
3 INT224284 BDNF Positive_regulation of Ephb1 1 0.36 0.22 0.36 78.96
4 INT224285 BDNF Positive_regulation of Trib3 1 0.06 0.22 0.36 78.56
5 INT51260 Calca Negative_regulation of Nts 1 0.10 0.08 1.01 77.72
6 INT51261 Calca Negative_regulation of Sst 1 0.20 0.08 1.01 77.72
7 INT224280 Bdnf Positive_regulation of Creb1 3 0.30 0.62 0.77 16.80
8 INT349658 Nos2 Regulation of Gene_expression of Nos1 1 0.63 2.86 1.84 5.00
9 INT349657 Nos2 Regulation of Regulation of Nos1 1 0.24 0.9 0.8 5.00
10 INT224281 Bdnf Regulation of Gene_expression of Gap43 1 0.36 0.4 0.77 5.00
11 INT224283 Bdnf Regulation of Gene_expression of Calca 1 0.19 0.35 0.76 5.00
12 INT204943 Il6 Regulation of Slc39a14 1 0.00 0.54 0.36 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Sciatic Neuropathy. They are ordered first by their pain relevance and then by number of times they were reported in Sciatic Neuropathy. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT16259 Positive_regulation of Bdnf 336 0.70 183.48 209.82 99.98
2 INT47685 Positive_regulation of Positive_regulation of Bdnf 32 0.70 20.05 27.03 99.98
3 INT61541 Positive_regulation of Gene_expression of Ngfr 7 0.53 2.87 2.75 99.98
4 INT63936 Positive_regulation of Phosphorylation of Ephb1 131 0.70 49.38 73.16 99.98
5 INT224279 Positive_regulation of Positive_regulation of Gap43 3 0.39 2.08 0.57 99.98
6 INT14306 Positive_regulation of Gal 36 0.70 21.66 18.51 99.92
7 INT10241 Positive_regulation of Gap43 26 0.70 9.89 8.54 99.84
8 INT55908 Gene_expression of Ngfr 74 0.78 34.46 28.8 99.56
9 INT172789 Regulation of Gene_expression of Nos3 15 0.53 16.23 7.86 99.40
10 INT77433 Regulation of Gene_expression of Nos2 49 0.62 35.07 16.33 99.40
11 INT16260 Gene_expression of Bdnf 671 0.78 283.44 339.1 99.32
12 INT49651 Gene_expression of Creb1 276 0.78 114.77 111.96 99.08
13 INT63934 Phosphorylation of Ephb1 377 0.82 150.52 188.66 99.08
14 INT66280 Gene_expression of Nos2 534 0.78 330.78 157.07 98.80
15 INT77434 Positive_regulation of Gene_expression of Nos2 151 0.69 96.76 38.94 98.80
16 INT65245 Gene_expression of Nos3 121 0.78 98.14 41.56 98.44
17 INT121242 Positive_regulation of Gene_expression of Nos3 37 0.69 31.96 12.71 98.44
18 INT51163 Gene_expression of Gal 119 0.78 67.48 49.23 98.16
19 INT15229 Positive_regulation of CNDP1 21 0.69 15.86 4.06 98.16
20 INT5228 Positive_regulation of Fos 934 0.70 209.8 503.87 98.16
21 INT63932 Positive_regulation of Ephb1 537 0.70 259.67 296.14 98.04
22 INT66038 Positive_regulation of Ngfr 32 0.69 26.07 11.75 97.40
23 INT97254 Positive_regulation of Gap43 22 0.46 7.36 4.48 97.40
24 INT96557 Binding of Bdnf 46 0.47 21.74 24.26 97.04
25 INT48923 Gene_expression of Ephb1 211 0.77 106.23 109.9 96.98
26 INT25334 Negative_regulation of Pla2g2a 16 0.56 9.01 4.23 96.76
27 INT51474 Binding of Il6 55 0.48 44.99 20.52 96.68
28 INT170025 Gene_expression of Fig4 588 0.67 183.27 113.32 96.44
29 INT67682 Localization of Bdnf 204 0.81 72.36 88.92 96.12
30 INT142667 Localization of RPL4P5 1 0.04 0.29 0.24 95.80
31 INT142666 Binding of RPL4P5 1 0.02 0.28 0.23 95.80
32 INT79758 Regulation of Gene_expression of Gal 6 0.54 5.45 3.22 95.76
33 INT4891 Transcription of Calca 81 0.72 35.27 53.75 95.16
34 INT18457 Transcription of Sst 25 0.69 4.28 18.25 95.16
35 INT48761 Transcription of Gal 13 0.69 8.53 8.61 95.16
36 INT61542 Positive_regulation of Ngfr 15 0.70 6.35 7.34 93.56
37 INT79093 Positive_regulation of Nos1 101 0.70 46.89 59.61 93.16
38 INT75921 Negative_regulation of Ngfr 13 0.59 8.58 8.35 92.40
39 INT10240 Gene_expression of Gap43 58 0.78 22.11 24.45 92.00
40 INT11014 Phosphorylation of CREB1 72 0.81 26.35 25.64 91.60
41 INT87687 Positive_regulation of Trpv1 409 0.70 210.24 257.59 91.08
42 INT79406 Negative_regulation of Pde4a 20 0.59 25.26 8.35 86.88
43 INT157399 Localization of Pcyt1b 9 0.69 2.3 2.54 86.80
44 INT56047 Negative_regulation of Transcription of Bdnf 16 0.59 8.02 5.67 86.40
45 INT2910 Regulation of Abat 169 0.62 36.95 153.53 85.84
46 INT10534 Positive_regulation of Trib3 209 0.60 78.75 81.48 85.80
47 INT79737 Positive_regulation of Ntrk1 12 0.49 3.98 6.24 85.80
48 INT89854 Regulation of Nos2 49 0.61 42.58 24.1 85.28
49 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 84.60
50 INT4958 Gene_expression of Pcyt1b 18 0.65 3.4 5.66 84.56
51 INT140247 Negative_regulation of Negative_regulation of Ngfr 3 0.33 3.15 1.59 83.52
52 INT16261 Transcription of Bdnf 101 0.72 49.41 40.64 83.52
53 INT77435 Positive_regulation of Nos2 343 0.70 208.49 91.43 82.12
54 INT24527 Negative_regulation of Gal 12 0.59 7.16 6.29 82.12
55 INT47690 Regulation of Bdnf 118 0.62 53.02 64.5 81.28
56 INT16253 Positive_regulation of Gene_expression of Bdnf 196 0.70 92.67 113.01 80.32
57 INT224278 Transcription of Pcyt1b 1 0.29 0.41 0.45 80.12
58 INT48929 Regulation of Ephb1 71 0.62 24.42 42.11 78.96
59 INT83229 Regulation of Regulation of Bdnf 6 0.45 4.62 0.92 77.44
60 INT51392 Negative_regulation of Insr 18 0.27 14.75 4.84 75.52
61 INT2540 Negative_regulation of Calca 538 0.59 172.11 384.38 75.00
62 INT2649 Regulation of Calca 433 0.62 146.05 330.95 75.00
63 INT613 Gene_expression of Alb 268 0.78 149.84 42.78 75.00
64 INT3971 Positive_regulation of Alb 175 0.70 98.46 36.45 75.00
65 INT6361 Localization of Edn1 30 0.81 19.09 9.7 75.00
66 INT4422 Positive_regulation of Gene_expression of Alb 30 0.50 18.56 6.12 75.00
67 INT65640 Positive_regulation of Localization of Edn1 2 0.42 2.16 1.48 75.00
68 INT74232 Binding of RPSAP8 1 0.06 0.93 0.07 70.40
69 INT27798 Gene_expression of Ntrk2 111 0.78 56.08 42.68 70.08
70 INT67116 Gene_expression of Ntrk3 20 0.59 7.64 8.94 70.08
71 INT49171 Gene_expression of Nos1 241 0.78 140.7 104.76 68.56
72 INT64110 Positive_regulation of Gene_expression of Nos1 68 0.70 58.11 51.64 68.56
73 INT5207 Negative_regulation of Alms1 70 0.41 41.56 13.68 65.52
74 INT76660 Gene_expression of Trpv1 691 0.78 329.46 386.42 60.88
75 INT103320 Positive_regulation of Positive_regulation of Trpv1 44 0.70 27.73 25.28 58.72
76 INT75999 Gene_expression of BDNF 344 0.78 114.19 83.12 56.72
77 INT103469 Positive_regulation of Gene_expression of BDNF 59 0.67 24.39 18.36 56.72
78 INT6852 Localization of TNF 883 0.81 705.95 270.84 54.16
79 INT147896 Negative_regulation of Gene_expression of Gap43 6 0.58 1.01 1.94 53.84
80 INT94118 Localization of Tnfrsf1a 9 0.72 7.24 5.81 53.60
81 INT94119 Localization of Tnfrsf1b 8 0.75 5.66 2.42 53.20
82 INT1912 Gene_expression of Calca 1152 0.78 453.25 739.84 51.40
83 INT96299 Positive_regulation of Localization of Bdnf 35 0.70 15.67 16.09 49.60
84 INT13897 Localization of Sst 65 0.81 14.91 32.24 48.96
85 INT67620 Negative_regulation of Gene_expression of Bdnf 53 0.59 22.45 28.5 48.32
86 INT114025 Transcription of Nos1 20 0.70 16.48 15.63 48.32
87 INT114023 Positive_regulation of Transcription of Nos1 7 0.60 5.35 8.06 48.32
88 INT64112 Regulation of Gene_expression of Nos1 22 0.62 21.45 14.76 47.28
89 INT112190 Regulation of Negative_regulation of Nos2 8 0.62 5.83 5.09 42.68
90 INT86062 Positive_regulation of Tnfrsf1a 51 0.69 40.69 26.2 40.24
91 INT85943 Negative_regulation of Nos2 161 0.59 108.56 42.65 39.56
92 INT183212 Positive_regulation of Regulation of Bdnf 4 0.45 1.57 3.14 38.88
93 INT49172 Regulation of Nos1 43 0.52 27.53 23.66 24.24
94 INT116605 Binding of Nos2 28 0.37 16.88 8.18 13.52
95 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
96 INT797 Regulation of Penk 812 0.62 111.13 542.24 5.00
97 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 5.00
98 INT6665 Gene_expression of FOS 520 0.77 165.31 217.66 5.00
99 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 5.00
100 INT9660 Regulation of TNF 363 0.62 312.94 139.99 5.00
101 INT8243 Positive_regulation of Il6 451 0.70 358.24 119.28 5.00
102 INT8357 Gene_expression of KNG1 153 0.75 77.26 68.66 5.00
103 INT11937 Localization of Il6 228 0.81 139.83 64.39 5.00
104 INT9657 Positive_regulation of Gene_expression of Il6 237 0.70 180.45 63.6 5.00
105 INT49170 Negative_regulation of Nos1 116 0.59 60.66 58.87 5.00
106 INT11491 Positive_regulation of KNG1 128 0.67 60.41 58.74 5.00
107 INT17458 Negative_regulation of Gene_expression of FOS 98 0.57 36.77 55.69 5.00
108 INT771 Regulation of Nts 93 0.61 13.13 53.57 5.00
109 INT47683 Negative_regulation of Bdnf 92 0.59 47.53 43.55 5.00
110 INT170054 Negative_regulation of Gopc 280 0.38 117.89 42.4 5.00
111 INT9655 Regulation of Il6 98 0.62 70.92 31.95 5.00
112 INT92837 Negative_regulation of Gene_expression of Nos2 116 0.59 59.67 31.82 5.00
113 INT1613 Binding of Nts 58 0.48 10.55 28.18 5.00
114 INT66281 Transcription of Nos2 81 0.71 39.49 20.37 5.00
115 INT46016 Gene_expression of Ngfr 69 0.77 41.22 19.8 5.00
116 INT11938 Positive_regulation of Localization of Il6 61 0.70 35.72 18.25 5.00
117 INT8379 Regulation of Qrfp 26 0.60 2.56 15.82 5.00
118 INT8210 Positive_regulation of Gene_expression of INS 188 0.68 146.57 12.83 5.00
119 INT65057 Regulation of Nfkb1 28 0.47 16.48 11.62 5.00
120 INT104441 Binding of NOVA2 72 0.42 16.41 10.51 5.00
121 INT6574 Negative_regulation of Pla2g1b 35 0.59 11.4 10.44 5.00
122 INT71381 Localization of Nos1 33 0.79 11.46 8.05 5.00
123 INT26551 Positive_regulation of Gene_expression of KNG1 19 0.67 11.05 7.98 5.00
124 INT64111 Negative_regulation of Gene_expression of Nos1 22 0.57 8.96 6.02 5.00
125 INT62336 Positive_regulation of Hdc 38 0.70 14.45 5.51 5.00
126 INT49375 Regulation of Localization of Il6 16 0.62 4.54 5.08 5.00
127 INT10138 Negative_regulation of Gene_expression of KNG1 13 0.57 9.57 4.9 5.00
128 INT15648 Positive_regulation of RYR1 30 0.67 12.03 3.26 5.00
129 INT6578 Regulation of Pla2g1b 11 0.49 3.94 3.19 5.00
130 INT116235 Negative_regulation of Transcription of Nos2 23 0.58 7.91 3.14 5.00
131 INT82913 Regulation of Ppara 15 0.61 10.66 3.03 5.00
132 INT98607 Regulation of Regulation of TNF 8 0.44 6.95 2.56 5.00
133 INT89852 Localization of Nos2 22 0.78 14.89 2.56 5.00
134 INT145101 Transcription of Nos3 8 0.70 6.04 2.47 5.00
135 INT73809 Regulation of Nos3 18 0.45 10.05 2.27 5.00
136 INT144792 Negative_regulation of Transcription of Nos1 2 0.43 1.74 2.27 5.00
137 INT105824 Regulation of Casq1 4 0.07 2.66 2.1 5.00
138 INT6508 Gene_expression of RYR1 34 0.77 11.11 2.04 5.00
139 INT59244 Regulation of Pla2g2a 5 0.57 3.02 1.82 5.00
140 INT92547 Regulation of Localization of Nos1 2 0.43 0.61 0.7 5.00
141 INT108735 Regulation of Localization of Nos2 3 0.42 0.52 0.46 5.00
142 INT204941 Protein_catabolism of Timp2 1 0.03 0.35 0.32 5.00
143 INT166811 Regulation of Casq1 3 0.04 1.18 0.1 5.00
144 INT204938 Positive_regulation of Casq1 1 0.08 0.17 0.03 5.00
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