D:Sclerosing Cholangitis

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Disease Term
Synonyms CHOLANGIITIDES SCLEROSING, Cholangiitis Sclerosing, Cholangitides Sclerosing, Sclerosing Cholangiitides, Sclerosing Cholangiitis, SCLEROSING CHOLANGITIDES
Documents 127
Hot Single Events 28
Hot Interactions 1

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Sclerosing Cholangitis. They are ordered first by their relevance to Sclerosing Cholangitis and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT287794 Binding of IGHG3 and AIP 1 0.05 2.8 0.24 92.96
2 INT101942 Binding of CD40 and CD40LG 16 0.23 15.24 4.01 5.00
3 INT83422 Binding of FANCB and IGHG3 3 0.12 5.09 1.22 5.00
4 INT225067 Binding of ETF1 and IGHG3 1 0.03 4.52 1.17 5.00
5 INT185997 Binding of FANCB and fc 2 0.01 2.51 0.63 5.00
6 INT225065 Binding of ETF1 and FANCB 1 0.01 2.07 0.59 5.00
7 INT225083 Binding of ETF1 and fc 1 0.00 2.13 0.57 5.00
8 INT225082 Binding of IGHG3 and fc 6 0.01 3.6 0.55 5.00
9 INT254360 Binding of EPAS1 and HIF1A 3 0.39 3.36 0.46 5.00
10 INT277995 TNF Positive_regulation of Gene_expression of Tnfrsf1a 1 0.03 1.48 0.22 5.00
11 INT277996 TNF Positive_regulation of Tnfrsf1a 1 0.03 1.48 0.22 5.00
12 INT276301 Binding of CCL21 and CXCL13 1 0.04 1.85 0.18 5.00
13 INT198307 IL10 Positive_regulation of Gene_expression of IGHG3 2 0.01 1.21 0.15 5.00
14 INT227400 Binding of DLAT and HCC 1 0.01 2.82 0.11 5.00
15 INT276304 PRDM1 Regulation of TSC1 1 0.01 1.29 0.09 5.00
16 INT276391 Prdm1 Regulation of TSC1 1 0.00 1.29 0.09 5.00
17 INT199031 Binding of ALB and F2 1 0.05 1.78 0.08 5.00
18 INT276375 Binding of Prdm1 and MIR9-1 1 0.12 1.12 0.08 5.00
19 INT276383 Binding of PRDM1 and Mirlet7a-1 1 0.39 1.12 0.08 5.00
20 INT276334 Binding of Prdm1 and Mirlet7a-1 1 0.12 1.13 0.08 5.00
21 INT276384 Binding of Mirlet7a-1 and MIR9-1 1 0.39 1.12 0.08 5.00
22 INT227418 Binding of DLAT and Pdc 1 0.05 1.01 0.07 5.00
23 INT225068 Binding of FCAR and IGHG3 1 0.02 0.27 0.07 5.00
24 INT225081 Binding of FCAR and fc 1 0.00 0.27 0.07 5.00
25 INT225064 Binding of IGHA1 and IGHG3 1 0.01 1.54 0.07 5.00
26 INT276337 Timp1 Positive_regulation of Il10 1 0.01 0.76 0.05 5.00
27 INT276386 Gtf3a Regulation of PTPN6 1 0.00 0.86 0.04 5.00
28 INT276381 Timp1 Positive_regulation of CD44 1 0.07 0.72 0.04 5.00
29 INT276392 Timp1 Regulation of PTPN6 1 0.02 0.87 0.04 5.00
30 INT276376 Gtf3a Regulation of CD44 1 0.00 0.86 0.04 5.00
31 INT276385 Timp1 Regulation of CD44 1 0.04 0.87 0.04 5.00
32 INT276377 Binding of Lgals1 and KRT20 1 0.00 1.11 0.03 5.00
33 INT276388 Il22 Positive_regulation of STAT3 1 0.03 1.3 0.03 5.00
34 INT276305 Binding of LGALS1 and KRT20 1 0.01 1.11 0.03 5.00
35 INT276389 Binding of Trp53 and KRT20 1 0.01 0.97 0.03 5.00
36 INT276382 Binding of CIB1 and Skp2 1 0.01 0.57 0 5.00
37 INT225084 IGHG3 Negative_regulation of fc 1 0.01 0.24 0 5.00
38 INT276300 TAT Regulation of Gene_expression of VEGFA 1 0.14 1.58 0 5.00
39 INT276390 Positive_regulation of CD40 Positive_regulation of Gene_expression of Pdcd1 1 0.01 1.06 0 5.00
40 INT276378 CD40 Positive_regulation of Gene_expression of Pdcd1 1 0.01 1.06 0 5.00
41 INT276387 ALK Positive_regulation of Gene_expression of Il22ra1 1 0.00 1.55 0 5.00
42 INT276380 Binding of PIM1 and Trp53 1 0.01 0.66 0 5.00
43 INT276379 Binding of SKP2 and Cdkn1b 1 0.02 0.57 0 5.00
44 INT276303 Negative_regulation of AKT1 Negative_regulation of CCND1 1 0.01 0.58 0 5.00
45 INT276336 Skp2 Regulation of Cdkn1b 1 0.00 0.57 0 5.00
46 INT276374 Skp2 Regulation of Protein_catabolism of CIB1 1 0.00 0.58 0 5.00
47 INT276335 Binding of Cdkn1b and Skp2 1 0.00 0.57 0 5.00
48 INT276333 Binding of Il10rb and Il22ra1 1 0.00 1.25 0 5.00
49 INT276302 Binding of SKP2 and CIB1 1 0.03 0.57 0 5.00
50 INT225080 Positive_regulation of IGHG3 Negative_regulation of fc 1 0.01 0.24 0 5.00
51 INT276393 Skp2 Regulation of CIB1 1 0.00 0.57 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Sclerosing Cholangitis. They are ordered first by their pain relevance and then by number of times they were reported in Sclerosing Cholangitis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT120062 Binding of AIP 4 0.42 28.86 3.91 99.98
2 INT1125 Positive_regulation of IGHG3 130 0.69 112.07 13.18 99.88
3 INT4003 Positive_regulation of Gene_expression of IGHG3 31 0.46 20.38 3.16 99.88
4 INT287799 Positive_regulation of Gene_expression of AIP 1 0.42 7.39 1.19 99.80
5 INT4004 Gene_expression of IGHG3 321 0.71 221.03 42.33 99.58
6 INT4420 Positive_regulation of GOT1 103 0.64 88.4 18.38 98.70
7 INT1624 Gene_expression of Cea 212 0.76 180.44 34.21 98.52
8 INT15514 Negative_regulation of Crp 275 0.59 194.6 64.86 95.68
9 INT49266 Positive_regulation of Arigg4 37 0.47 53.79 11.2 95.00
10 INT5398 Positive_regulation of ALPP 178 0.70 110.52 19.18 94.00
11 INT285 Positive_regulation of Salpa1 73 0.68 61.47 9.19 93.40
12 INT105114 Gene_expression of Arigg4 16 0.52 21.88 4.56 92.92
13 INT37530 Regulation of Salpa1 8 0.59 4.79 1.19 92.88
14 INT287798 Localization of AIP 1 0.63 5.96 1.31 92.60
15 INT287797 Phosphorylation of AIP 1 0.78 2.04 0.16 92.52
16 INT112989 Gene_expression of AIP 3 0.56 25.4 4.23 92.32
17 INT10016 Negative_regulation of CD8A 81 0.42 56.68 13.15 89.28
18 INT10709 Negative_regulation of CD4 106 0.59 95.6 14.89 88.96
19 INT287795 Localization of FAM190B 1 0.05 2.71 0.33 88.92
20 INT2723 Gene_expression of Salpa1 16 0.64 11.78 3.5 86.96
21 INT57720 Localization of IGHG3 33 0.74 20.24 6.25 86.76
22 INT13960 Gene_expression of GGT6 5 0.62 4.18 3.01 86.32
23 INT12265 Positive_regulation of IgG 168 0.63 104.89 19.76 85.28
24 INT121801 Binding of Aip 18 0.36 24.1 5.26 84.64
25 INT11657 Gene_expression of ALPI 11 0.71 5.13 0.74 83.92
26 INT163592 Localization of CISH 5 0.54 5.9 1.26 82.80
27 INT182667 Binding of DLAT 11 0.31 40.75 2.8 81.68
28 INT171666 Regulation of GOPC 117 0.39 40.41 15.47 80.20
29 INT68244 Positive_regulation of Ighg1 60 0.61 48.86 5.01 79.76
30 INT154613 Regulation of Aip 5 0.21 3.86 0.55 79.68
31 INT16449 Binding of IGHG3 67 0.48 39.55 10.59 79.64
32 INT127645 Positive_regulation of CD200 3 0.39 1.97 0.58 75.76
33 INT9852 Positive_regulation of Gpt 563 0.70 364.64 146.82 70.40
34 INT138685 Positive_regulation of IGHG4 1 0.01 1.02 0.18 68.00
35 INT149158 Positive_regulation of Sema4g 1 0.00 1.2 0.31 66.48
36 INT138683 Regulation of Ighg1 15 0.30 7.95 0.94 64.16
37 INT138684 Regulation of Iresp3 1 0.00 1 0.18 64.16
38 INT9223 Localization of Ighg1 22 0.78 11.03 3.67 59.68
39 INT90300 Gene_expression of Abcb1a 56 0.78 11.05 22.89 56.48
40 INT78659 Gene_expression of Thim 17 0.28 14.34 4.4 55.36
41 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 51.96
42 INT52021 Regulation of IGHG3 34 0.39 22.43 3.3 21.56
43 INT21999 Regulation of Gene_expression of IGHG3 8 0.30 3.26 1.84 21.56
44 INT287796 Regulation of Positive_regulation of IGHG3 1 0.02 1.19 0.03 21.56
45 INT210020 Localization of Abcb4 3 0.71 1.65 0.34 9.84
46 INT272794 Positive_regulation of Positive_regulation of IGHG3 3 0.04 2.84 0.17 6.28
47 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
48 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 5.00
49 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
50 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
51 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 5.00
52 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 5.00
53 INT6481 Binding of TNF 624 0.48 510.2 214.82 5.00
54 INT15516 Gene_expression of Crp 711 0.77 615.33 173.09 5.00
55 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 5.00
56 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 5.00
57 INT812 Localization of INS 1026 0.81 515.6 145.31 5.00
58 INT20374 Gene_expression of Il4 515 0.76 306.15 114.12 5.00
59 INT118381 Gene_expression of Il17a 405 0.76 306.97 112.06 5.00
60 INT60526 Gene_expression of IL10 449 0.78 292.71 107.84 5.00
61 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
62 INT5056 Gene_expression of IFNG 216 0.78 137.52 74.57 5.00
63 INT56298 Gene_expression of IL4 306 0.78 182.18 72.92 5.00
64 INT3375 Gene_expression of IGHE 535 0.77 387.47 65.46 5.00
65 INT11937 Localization of Il6 228 0.81 139.83 64.39 5.00
66 INT11318 Gene_expression of Gtf3a 274 0.52 183.82 60.89 5.00
67 INT9408 Positive_regulation of Crp 296 0.69 242.27 57.35 5.00
68 INT4509 Gene_expression of IgG 426 0.76 293.69 56.64 5.00
69 INT20375 Gene_expression of Hand1 213 0.60 148.51 54.53 5.00
70 INT22112 Positive_regulation of Localization of TNF 164 0.70 115.66 52.18 5.00
71 INT20382 Gene_expression of Hand2 211 0.66 142.26 51.05 5.00
72 INT2604 Positive_regulation of Got1 223 0.70 154.78 49.51 5.00
73 INT16364 Gene_expression of HLA-DRA 234 0.78 118.81 45.01 5.00
74 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53 5.00
75 INT4216 Gene_expression of CD40LG 328 0.78 256.02 44.23 5.00
76 INT73502 Positive_regulation of IL10 154 0.69 124.87 43.5 5.00
77 INT100939 Gene_expression of Il13 176 0.73 125.1 43.38 5.00
78 INT13556 Gene_expression of CD4 367 0.78 230.82 41.74 5.00
79 INT3987 Positive_regulation of IGHE 316 0.70 283.2 40.16 5.00
80 INT168410 Gene_expression of Cxcr3 81 0.75 84.03 37.01 5.00
81 INT9082 Positive_regulation of ESR1 238 0.69 148.51 36.69 5.00
82 INT3253 Negative_regulation of Localization of INS 205 0.59 130.39 36.61 5.00
83 INT12892 Negative_regulation of TIMP1 136 0.58 83.13 36.54 5.00
84 INT60710 Gene_expression of Col7a1 217 0.78 113.2 35.2 5.00
85 INT20380 Gene_expression of Il5 172 0.78 104.75 34.78 5.00
86 INT666 Gene_expression of Jun 124 0.78 54.61 33.67 5.00
87 INT10248 Gene_expression of KRT20 436 0.78 231.96 32.88 5.00
88 INT7538 Negative_regulation of IL2 95 0.57 47.31 31.7 5.00
89 INT99688 Negative_regulation of Gene_expression of VEGFA 274 0.58 201.8 31.1 5.00
90 INT65960 Gene_expression of BCL2 352 0.78 312.03 30.73 5.00
91 INT90792 Localization of Il10 144 0.80 87.88 30.03 5.00
92 INT6660 Positive_regulation of Jun 148 0.69 67.58 29.73 5.00
93 INT17331 Positive_regulation of JUN 132 0.69 60.4 27.03 5.00
94 INT59449 Negative_regulation of Timp1 76 0.42 54.86 26.99 5.00
95 INT69157 Gene_expression of IL5 127 0.77 102.58 26.81 5.00
96 INT19856 Gene_expression of CD8A 240 0.75 147.86 26.39 5.00
97 INT11159 Gene_expression of EGFR 698 0.78 548.93 25.69 5.00
98 INT4877 Gene_expression of MME 184 0.78 122.82 24.78 5.00
99 INT8775 Binding of IGHE 167 0.48 102.61 23.54 5.00
100 INT93738 Gene_expression of Tnfrsf1a 63 0.74 57.66 23.09 5.00
101 INT5055 Positive_regulation of IFNG 89 0.69 64.03 23.05 5.00
102 INT1558 Positive_regulation of Dnahc8 30 0.69 5.78 22.19 5.00
103 INT8483 Positive_regulation of Positive_regulation of TNF 73 0.67 60.35 22.03 5.00
104 INT5328 Positive_regulation of CD4 191 0.69 133.43 21.31 5.00
105 INT1561 Negative_regulation of Dnahc8 59 0.59 18.12 20.99 5.00
106 INT160564 Gene_expression of Il22 64 0.55 59.29 20.9 5.00
107 INT20379 Localization of Il4 85 0.73 51.22 20.55 5.00
108 INT86187 Positive_regulation of AKT1 199 0.69 122.13 19.44 5.00
109 INT18311 Positive_regulation of CD8A 145 0.69 113.48 19.44 5.00
110 INT56301 Positive_regulation of IL4 68 0.56 54.51 18.65 5.00
111 INT18010 Positive_regulation of CD40LG 122 0.70 100.8 18.46 5.00
112 INT112017 Regulation of Hand2 77 0.36 62.23 18.04 5.00
113 INT38056 Localization of Crp 71 0.78 53.14 17.03 5.00
114 INT104045 Regulation of Hand1 65 0.35 51.32 16.26 5.00
115 INT65659 Positive_regulation of STAT3 132 0.70 69.56 15.95 5.00
116 INT9220 Gene_expression of Ighg1 125 0.77 85.74 15.92 5.00
117 INT25223 Positive_regulation of Gene_expression of IFNG 41 0.67 36.97 15.89 5.00
118 INT81627 Gene_expression of Fas 120 0.78 115.51 15.36 5.00
119 INT34590 Gene_expression of ALPP 199 0.75 89.85 15.1 5.00
120 INT109535 Gene_expression of Vegfa 116 0.75 84.61 14.89 5.00
121 INT105387 Gene_expression of HIF1A 116 0.77 98.62 14.66 5.00
122 INT60197 Gene_expression of JUN 90 0.78 42.32 14.61 5.00
123 INT124372 Gene_expression of Gsk3b 164 0.75 95.64 14.35 5.00
124 INT3796 Gene_expression of Ighm 130 0.77 69.61 13.78 5.00
125 INT56651 Binding of HLA-DRB1 58 0.48 52.25 13.68 5.00
126 INT20378 Localization of Hand1 53 0.71 41.96 13.31 5.00
127 INT89395 Negative_regulation of AKT1 127 0.58 70.27 12.54 5.00
128 INT148207 Gene_expression of CTLA4 53 0.77 29.13 12.07 5.00
129 INT69029 Gene_expression of PTPRC 127 0.75 74.26 11.57 5.00
130 INT23402 Binding of HLA-DOA 74 0.48 52.01 10.89 5.00
131 INT108479 Positive_regulation of CCL21 18 0.67 19.93 10.76 5.00
132 INT701 Localization of IGHE 87 0.80 40.5 10.62 5.00
133 INT1934 Positive_regulation of Cys1 68 0.68 60.56 10.47 5.00
134 INT35164 Negative_regulation of IGHE 96 0.58 76.3 9.74 5.00
135 INT3988 Positive_regulation of Gene_expression of IGHE 98 0.68 91.46 9.61 5.00
136 INT87193 Gene_expression of Tnfrsf1b 30 0.58 29.4 9.22 5.00
137 INT1118 Gene_expression of C6orf25 73 0.77 47.24 9.1 5.00
138 INT20371 Gene_expression of Cd8a 125 0.60 67.59 8.97 5.00
139 INT59165 Binding of fc 67 0.36 37.51 8.68 5.00
140 INT119831 Gene_expression of PTEN 55 0.75 40.37 8.57 5.00
141 INT169015 Gene_expression of FOXP3 50 0.60 33.18 8.4 5.00
142 INT86705 Gene_expression of BTG3 41 0.65 37.29 8.29 5.00
143 INT36798 Gene_expression of Mki67 178 0.77 132 8.24 5.00
144 INT725 Negative_regulation of IgG 62 0.41 37.21 8.16 5.00
145 INT80220 Positive_regulation of Bcl2 71 0.58 57.73 7.86 5.00
146 INT276358 Gene_expression of MIR150 42 0.74 38.44 7.82 5.00
147 INT11823 Positive_regulation of GGT1 53 0.67 45.84 7.55 5.00
148 INT39417 Gene_expression of Fcer2a 65 0.76 32.1 7.37 5.00
149 INT67112 Positive_regulation of fc 27 0.58 21.17 7.2 5.00
150 INT93003 Binding of CD40 28 0.47 20.25 7.13 5.00
151 INT13520 Binding of HLA-DRB4 30 0.42 32.65 6.74 5.00
152 INT84685 Regulation of BCL2 67 0.60 72.96 6.65 5.00
153 INT23246 Gene_expression of HLA-DRB4 37 0.64 36.79 6.61 5.00
154 INT181525 Localization of Il13 24 0.66 21.51 6.55 5.00
155 INT10094 Negative_regulation of ALPP 36 0.37 20.45 6.45 5.00
156 INT38672 Binding of KRT20 69 0.39 48.01 6.31 5.00
157 INT69985 Positive_regulation of Negative_regulation of TNF 21 0.50 13.26 6.31 5.00
158 INT93359 Positive_regulation of Trp53 90 0.70 69.77 6.24 5.00
159 INT17551 Positive_regulation of Gene_expression of HLA-DRA 31 0.70 15.39 6 5.00
160 INT75501 Gene_expression of CCND1 90 0.76 60.86 5.93 5.00
161 INT236839 Positive_regulation of CXCL13 14 0.44 19.27 5.81 5.00
162 INT77146 Binding of IL4 23 0.36 13.69 5.39 5.00
163 INT22907 Positive_regulation of Ggt1 33 0.67 17.82 5.28 5.00
164 INT76313 Gene_expression of CD38 30 0.64 20.74 5.27 5.00
165 INT34358 Binding of MME 13 0.37 7.25 5.14 5.00
166 INT2065 Binding of BTG3 15 0.36 10.9 4.65 5.00
167 INT57338 Gene_expression of ITGAX 31 0.75 24.62 4.39 5.00
168 INT103155 Gene_expression of KDR 78 0.66 50.53 4.38 5.00
169 INT187836 Binding of Tnfrsf1a 19 0.46 18.08 4.33 5.00
170 INT19449 Binding of FANCB 22 0.47 7.4 4.27 5.00
171 INT20372 Localization of Il5 26 0.41 18.33 4.27 5.00
172 INT64157 Positive_regulation of EPCAM 11 0.44 9.09 4.24 5.00
173 INT72747 Localization of IgG 55 0.53 30.88 4.19 5.00
174 INT91371 Negative_regulation of STAT3 34 0.59 25 4.08 5.00
175 INT149623 Negative_regulation of fc 17 0.12 10.56 4.05 5.00
176 INT92653 Gene_expression of IL12B 21 0.75 17.28 3.89 5.00
177 INT99509 Gene_expression of CFLAR 25 0.75 22.59 3.78 5.00
178 INT14717 Gene_expression of TAT 20 0.75 10.67 3.66 5.00
179 INT3564 Positive_regulation of Aip 11 0.58 15.38 3.62 5.00
180 INT62386 Negative_regulation of Gene_expression of IGHG3 12 0.20 7.94 3.62 5.00
181 INT135373 Regulation of Gsk3b 35 0.62 18.11 3.53 5.00
182 INT19491 Gene_expression of CD19 44 0.75 28.8 3.47 5.00
183 INT28359 Gene_expression of Pdcd1 39 0.57 34.09 3.4 5.00
184 INT59433 Gene_expression of PASK 24 0.68 25.13 3.21 5.00
185 INT80656 Regulation of SLC17A5 15 0.26 6.89 3.19 5.00
186 INT93913 Positive_regulation of CD40 21 0.58 23.47 3.1 5.00
187 INT45971 Negative_regulation of GOT1 9 0.51 6.2 2.84 5.00
188 INT181386 Positive_regulation of Cxcl12 12 0.69 15.35 2.84 5.00
189 INT38673 Negative_regulation of KRT20 38 0.42 22.49 2.77 5.00
190 INT134375 Gene_expression of Cflar 14 0.58 8.4 2.66 5.00
191 INT182224 Binding of CCL21 6 0.34 5.91 2.54 5.00
192 INT109968 Positive_regulation of Positive_regulation of Trp53 6 0.47 3.57 2.51 5.00
193 INT169765 Gene_expression of Mir16-1 6 0.63 3.21 2.47 5.00
194 INT4879 Positive_regulation of Gene_expression of MME 17 0.69 12.48 2.46 5.00
195 INT72782 Positive_regulation of HCC 41 0.40 63.74 2.46 5.00
196 INT100399 Gene_expression of CCL17 22 0.77 9.38 2.43 5.00
197 INT182238 Binding of CXCL13 5 0.33 5.32 2.37 5.00
198 INT70242 Localization of HCC 18 0.66 23.95 2.35 5.00
199 INT26434 Localization of MME 17 0.81 8.67 2.3 5.00
200 INT54615 Gene_expression of GPER 25 0.75 8.23 2.27 5.00
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