D:Scurvy

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pChart

Disease Term
Synonyms Scorbutus, SCURVIES
Documents 62
Hot Single Events 10
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Scurvy. They are ordered first by their relevance to Scurvy and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT181740 Il1 Positive_regulation of Csf2 1 0.02 0 0.12 5.00
2 INT346695 Negative_regulation of SOD1 Positive_regulation of Negative_regulation of Hist3h2a 1 0.00 0.41 0.08 5.00
3 INT217922 Binding of GSTA4 and SULT1D1P 1 0.29 0 0 5.00
4 INT217923 Positive_regulation of Binding of GSTA4 and SULT1D1P 1 0.37 0 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Scurvy. They are ordered first by their pain relevance and then by number of times they were reported in Scurvy. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT22781 Binding of COL7A1 76 0.48 41.59 6.66 93.88
2 INT2144 Localization of COL7A1 36 0.74 20.92 4.67 93.48
3 INT57274 Positive_regulation of Gene_expression of COL7A1 50 0.69 24.19 4.72 90.08
4 INT9094 Gene_expression of COL7A1 277 0.77 143.42 38.73 90.08
5 INT217947 Negative_regulation of CTF2P 1 0.17 0.37 0 88.96
6 INT97145 Positive_regulation of TBK1 14 0.12 15.32 5.43 88.56
7 INT63349 Gene_expression of PECAM1 199 0.75 166.03 36.76 87.44
8 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 86.12
9 INT8629 Positive_regulation of COL7A1 72 0.69 40.66 12.09 85.64
10 INT173876 Positive_regulation of Positive_regulation of COL7A1 3 0.25 1.57 0.24 85.64
11 INT217958 Negative_regulation of MBOAT1 3 0.01 0.26 0.04 71.76
12 INT164975 Binding of ELN 6 0.35 6.38 0.64 67.96
13 INT22871 Gene_expression of ELN 30 0.68 14.86 1.33 67.00
14 INT15490 Negative_regulation of Gene_expression of COL7A1 40 0.58 25.97 7.18 58.52
15 INT62669 Positive_regulation of COL1A2 13 0.49 6.89 1.4 49.16
16 INT155865 Positive_regulation of Transcription of COL1A2 2 0.46 0.6 0.34 49.16
17 INT155867 Transcription of COL1A2 8 0.69 2.9 0.94 48.40
18 INT90674 Negative_regulation of LOX 56 0.57 38.01 8.58 21.60
19 INT97132 Negative_regulation of Positive_regulation of TBK1 5 0.08 6.54 2.76 20.24
20 INT61363 Positive_regulation of TFAM 43 0.69 26.43 8.14 19.76
21 INT11380 Negative_regulation of IL1B 215 0.59 125.62 72.35 15.44
22 INT5905 Negative_regulation of ELANE 113 0.59 47.43 22.09 10.48
23 INT17582 Negative_regulation of Localization of ELANE 17 0.53 6.11 4.89 10.48
24 INT2609 Localization of ELANE 111 0.81 50.22 26.63 10.12
25 INT49238 Protein_catabolism of COL1A2 30 0.97 15.64 3.45 9.20
26 INT15144 Protein_catabolism of IL1B 11 0.92 4.67 2.58 9.20
27 INT209937 Negative_regulation of Protein_catabolism of IL1B 2 0.24 1.15 0.32 9.20
28 INT217925 Positive_regulation of 5330437I02Rik 1 0.26 0.22 0 6.96
29 INT217929 Negative_regulation of 5330437I02Rik 1 0.22 0.22 0 6.96
30 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
31 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
32 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 5.00
33 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 5.00
34 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 5.00
35 INT6481 Binding of TNF 624 0.48 510.2 214.82 5.00
36 INT19472 Gene_expression of Il1 554 0.76 419.75 175.35 5.00
37 INT867 Gene_expression of IFNA1 930 0.78 594.85 168.03 5.00
38 INT9852 Positive_regulation of Gpt 563 0.70 364.64 146.82 5.00
39 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 5.00
40 INT8243 Positive_regulation of Il6 451 0.70 358.24 119.28 5.00
41 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61 5.00
42 INT62124 Gene_expression of NOS1 444 0.78 218.08 114.85 5.00
43 INT48593 Positive_regulation of NOS1 420 0.68 226.15 114.71 5.00
44 INT11051 Positive_regulation of Gene_expression of IL6 415 0.69 319.21 109.3 5.00
45 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83 5.00
46 INT10272 Gene_expression of Il1b 194 0.78 121.02 103.03 5.00
47 INT12720 Positive_regulation of Il1 246 0.70 195.97 72.05 5.00
48 INT3375 Gene_expression of IGHE 535 0.77 387.47 65.46 5.00
49 INT11807 Gene_expression of Il2 266 0.78 112 64.97 5.00
50 INT11937 Localization of Il6 228 0.81 139.83 64.39 5.00
51 INT5058 Positive_regulation of IFNA1 356 0.70 245.75 60.52 5.00
52 INT546 Binding of ALB 311 0.48 85.98 60.14 5.00
53 INT19775 Localization of Il1 183 0.78 145.5 50.91 5.00
54 INT2604 Positive_regulation of Got1 223 0.70 154.78 49.51 5.00
55 INT25383 Gene_expression of Csf2 222 0.76 152.93 43.32 5.00
56 INT52732 Negative_regulation of CRP 169 0.59 138.47 40.33 5.00
57 INT3987 Positive_regulation of IGHE 316 0.70 283.2 40.16 5.00
58 INT3252 Negative_regulation of INS 428 0.59 271.65 39.52 5.00
59 INT10248 Gene_expression of KRT20 436 0.78 231.96 32.88 5.00
60 INT9993 Positive_regulation of Gene_expression of IL2 131 0.69 46.27 30.04 5.00
61 INT3286 Positive_regulation of Gpt 90 0.69 45.08 28.34 5.00
62 INT11361 Gene_expression of SERPINE1 183 0.78 136.45 27.97 5.00
63 INT11804 Positive_regulation of Gene_expression of Il2 70 0.70 33 21.63 5.00
64 INT12951 Negative_regulation of Cat 126 0.57 64.39 20.61 5.00
65 INT3952 Negative_regulation of ALB 116 0.59 72.18 18.35 5.00
66 INT9246 Positive_regulation of Cat 113 0.70 52.73 18.04 5.00
67 INT1284 Negative_regulation of Mmp13 20 0.57 36.21 14.91 5.00
68 INT39733 Localization of NFKB1 59 0.79 22.76 13.99 5.00
69 INT25076 Negative_regulation of Gene_expression of Il1 41 0.52 30.58 13.85 5.00
70 INT18773 Localization of ALB 117 0.80 69.18 13.8 5.00
71 INT69435 Negative_regulation of ROS1 74 0.51 50.38 13.71 5.00
72 INT14572 Binding of INS 205 0.48 175.43 13.38 5.00
73 INT31990 Positive_regulation of SOD1 124 0.69 67.79 12.52 5.00
74 INT27268 Localization of Gtf3a 71 0.21 56.93 12.51 5.00
75 INT90909 Negative_regulation of Gene_expression of NOS1 44 0.55 23.83 12.47 5.00
76 INT14510 Gene_expression of SOD1 208 0.76 88.56 12.4 5.00
77 INT94784 Binding of ROS1 113 0.40 71.57 10.26 5.00
78 INT3988 Positive_regulation of Gene_expression of IGHE 98 0.68 91.46 9.61 5.00
79 INT36449 Negative_regulation of G6PD 74 0.59 54.15 8.85 5.00
80 INT5194 Positive_regulation of Lpo 63 0.70 26.44 8.37 5.00
81 INT5195 Negative_regulation of Lpo 32 0.59 14.45 7.3 5.00
82 INT22834 Negative_regulation of CYP21A2 28 0.58 23.07 7.13 5.00
83 INT14903 Negative_regulation of SOD1 81 0.57 42.02 6.91 5.00
84 INT38672 Binding of KRT20 69 0.39 48.01 6.31 5.00
85 INT168383 Positive_regulation of Mmp13 27 0.67 17.9 6.27 5.00
86 INT34370 Positive_regulation of Cfp 26 0.46 15.21 6.12 5.00
87 INT25123 Negative_regulation of COL7A1 42 0.58 19.98 5.96 5.00
88 INT47976 Protein_catabolism of NFKBIA 17 0.88 7.57 5.79 5.00
89 INT38671 Positive_regulation of KRT20 62 0.53 40.17 5.6 5.00
90 INT183467 Negative_regulation of TBK1 6 0.12 9.89 5.41 5.00
91 INT9095 Regulation of Gene_expression of COL7A1 24 0.57 10.55 4.88 5.00
92 INT11565 Gene_expression of Tf 24 0.68 5.89 4.36 5.00
93 INT11635 Positive_regulation of Gene_expression of SERPINE1 35 0.68 24.57 4.26 5.00
94 INT155039 Gene_expression of ADAMTS5 23 0.67 7.85 3.22 5.00
95 INT104902 Regulation of ASIC1 6 0.51 5.17 3.13 5.00
96 INT37590 Regulation of COL7A1 15 0.54 9.4 3.12 5.00
97 INT92335 Gene_expression of TBK1 11 0.28 8.98 3 5.00
98 INT38673 Negative_regulation of KRT20 38 0.42 22.49 2.77 5.00
99 INT177459 Negative_regulation of RCT 13 0.25 7.9 2.7 5.00
100 INT21721 Gene_expression of Lpo 25 0.60 16.33 2.57 5.00
101 INT183468 Localization of TBK1 6 0.32 4.35 2.36 5.00
102 INT174028 Negative_regulation of ADAMTS5 10 0.19 3.18 1.99 5.00
103 INT83329 Regulation of Gene_expression of Tf 4 0.16 1.83 1.93 5.00
104 INT48722 Negative_regulation of Gene_expression of SERPINE1 12 0.43 7.66 1.85 5.00
105 INT183753 Regulation of HBM 24 0.39 13.13 1.79 5.00
106 INT64821 Positive_regulation of SLPI 11 0.67 5.08 1.48 5.00
107 INT258048 Regulation of TBK1 4 0.05 3.81 1.44 5.00
108 INT75746 Regulation of ZMYND10 3 0.44 0.5 1.31 5.00
109 INT167056 Gene_expression of CALR 29 0.75 20.05 1.25 5.00
110 INT183790 Binding of TBK1 2 0.04 2.97 1.16 5.00
111 INT132531 Positive_regulation of TAPBP 8 0.49 2.84 1.09 5.00
112 INT125356 Negative_regulation of Negative_regulation of Cat 4 0.42 2.66 1.06 5.00
113 INT217950 Positive_regulation of Negative_regulation of CYP21A2 2 0.03 1.34 0.97 5.00
114 INT47055 Gene_expression of RBP1 8 0.75 7.85 0.86 5.00
115 INT96012 Gene_expression of EBP 3 0.67 0.8 0.85 5.00
116 INT122160 Transcription of Adamts4 1 0.40 1.14 0.81 5.00
117 INT184216 Negative_regulation of Gene_expression of ADAMTS5 3 0.20 1.76 0.8 5.00
118 INT352771 Positive_regulation of Localization of TBK1 1 0.05 0.98 0.78 5.00
119 INT61474 Gene_expression of Prkcdbp 3 0.65 0.39 0.75 5.00
120 INT21720 Negative_regulation of Positive_regulation of Lpo 8 0.43 2.98 0.69 5.00
121 INT132528 Gene_expression of TAPBP 17 0.65 5.93 0.69 5.00
122 INT140711 Positive_regulation of EBP 1 0.29 0.72 0.68 5.00
123 INT333595 Negative_regulation of Gene_expression of TBK1 2 0.12 0.91 0.67 5.00
124 INT202140 Protein_catabolism of ROS1 7 0.28 2.58 0.62 5.00
125 INT127291 Transcription of ALB 7 0.67 4.26 0.55 5.00
126 INT202120 Binding of Lipo1 1 0.36 0.86 0.53 5.00
127 INT265005 Localization of Sds 4 0.35 1.15 0.47 5.00
128 INT129503 Positive_regulation of Enpp3 2 0.07 0.26 0.45 5.00
129 INT202138 Positive_regulation of Gene_expression of VIT 1 0.10 0.9 0.37 5.00
130 INT14569 Positive_regulation of Negative_regulation of INS 4 0.36 3.52 0.37 5.00
131 INT202137 Gene_expression of VIT 1 0.12 0.89 0.37 5.00
132 INT202139 Positive_regulation of VIT 1 0.07 0.86 0.36 5.00
133 INT181739 Gene_expression of Tpsg1 2 0.56 0.76 0.35 5.00
134 INT36751 Gene_expression of ZMYND10 7 0.75 3.92 0.32 5.00
135 INT181738 Positive_regulation of Localization of Gtf3a 4 0.02 2.46 0.25 5.00
136 INT88003 Gene_expression of MYH7 3 0.57 0.65 0.24 5.00
137 INT168380 Positive_regulation of Positive_regulation of Mmp13 2 0.49 0.48 0.22 5.00
138 INT316566 Negative_regulation of Hist3h2a 2 0.01 1.43 0.19 5.00
139 INT74573 Regulation of CTNND1 1 0.26 0.59 0.12 5.00
140 INT217951 Gene_expression of MYH16 3 0.62 0.25 0.1 5.00
141 INT341107 Negative_regulation of Localization of ELN 1 0.41 0.66 0.1 5.00
142 INT274185 Localization of ELN 4 0.73 1.25 0.1 5.00
143 INT217942 Negative_regulation of DARC 3 0.06 3.65 0.09 5.00
144 INT180293 Binding of EBP 3 0.37 0.06 0.09 5.00
145 INT217952 Negative_regulation of MYH7 2 0.01 1.85 0.09 5.00
146 INT346049 Localization of Aldh5a1 1 0.08 0.08 0.07 5.00
147 INT112219 Positive_regulation of CASP12 2 0.63 2.27 0.06 5.00
148 INT304993 Binding of CTNND1 1 0.02 0.19 0.06 5.00
149 INT217940 Negative_regulation of Gene_expression of MYH7 1 0.01 0.41 0.05 5.00
150 INT217955 Negative_regulation of Negative_regulation of DARC 1 0.06 0.38 0.05 5.00
151 INT194269 Gene_expression of NEPNP 3 0.50 1.1 0.05 5.00
152 INT259952 Negative_regulation of Negative_regulation of ALB 1 0.42 1.24 0.04 5.00
153 INT304992 Regulation of Binding of EBP 1 0.26 0 0.03 5.00
154 INT217939 Localization of RCHY1 1 0.14 0 0 5.00
155 INT217948 Localization of CATSPER2 1 0.45 0.23 0 5.00
156 INT217954 Negative_regulation of NEPNP 1 0.31 0.07 0 5.00
157 INT217945 Regulation of RCHY1 1 0.09 0 0 5.00
158 INT217938 Negative_regulation of CASP12 1 0.53 0.88 0 5.00
159 INT217943 Positive_regulation of Gene_expression of NEPNP 1 0.37 0.55 0 5.00
160 INT217957 Positive_regulation of Gene_expression of CETN4P 1 0.04 0.48 0 5.00
161 INT217949 Negative_regulation of GPR33 1 0.38 0 0 5.00
162 INT217928 Binding of Pfpl 2 0.19 0.52 0 5.00
163 INT192535 Negative_regulation of GUCY2D 2 0.41 1.38 0 5.00
164 INT217961 Positive_regulation of Gene_expression of MYH16 1 0.41 0 0 5.00
165 INT217956 Negative_regulation of GULOP 1 0.45 0 0 5.00
166 INT217944 Negative_regulation of HTR5BP 1 0.28 0 0 5.00
167 INT338134 Positive_regulation of Gene_expression of ZMYND10 1 0.49 0.58 0 5.00
168 INT217927 Binding of Bpifb5 1 0.18 0 0 5.00
169 INT217926 Binding of Abca14 1 0.17 0 0 5.00
170 INT217941 Gene_expression of CETN4P 1 0.06 0.94 0 5.00
171 INT217960 Transcription of MYH16 1 0.57 0.24 0 5.00
172 INT217946 Negative_regulation of CMAHP 1 0.37 0 0 5.00
173 INT217953 Positive_regulation of Positive_regulation of CASP12 1 0.42 0.54 0 5.00
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