D:Second Primary Neoplasms

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Disease Term
Synonyms Cancer Second, Cancer Second Primary, Cancer Therapy Associated, Cancer Therapy Related, CANCER TREATMENT ASSOCIATED, CANCER TREATMENT RELATED, Cancers Second, Cancers Second Primary, Cancers Therapy Associated, CANCERS THERAPY RELATED, Cancers Treatment Associated
Documents 114
Hot Single Events 20
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Second Primary Neoplasms. They are ordered first by their relevance to Second Primary Neoplasms and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT191814 PDLIM7 Positive_regulation of TNFRSF8 1 0.08 1.16 0.08 34.40
2 INT191813 PDLIM7 Positive_regulation of FUT4 1 0.09 1.16 0.08 34.40
3 INT197040 SERPINE1 Regulation of PLAU 1 0.31 0.68 0 13.16
4 INT192332 UBR7 Negative_regulation of TXK 1 0.00 1.38 0.63 5.00
5 INT222301 Binding of ERBB2 and ESR1 5 0.36 5.07 0.29 5.00
6 INT192331 UBR7 Negative_regulation of INSRR 1 0.00 0.54 0.23 5.00
7 INT192333 PDGFA Positive_regulation of Gene_expression of FN1 2 0.11 1.26 0.18 5.00
8 INT339116 CNA1 Regulation of RSF1 1 0.00 0.3 0.13 5.00
9 INT192330 UBR7 Negative_regulation of Positive_regulation of PDGFRB 1 0.01 0.54 0.12 5.00
10 INT339111 Binding of ERBB2 and JUP 1 0.38 0.62 0.07 5.00
11 INT339108 Binding of ESR1 and JUP 1 0.38 0.62 0.07 5.00
12 INT192329 UBR7 Negative_regulation of Phosphorylation of PDGFRB 1 0.01 0.06 0.07 5.00
13 INT339101 ERBB2 Positive_regulation of TGFA 1 0.33 0.68 0.06 5.00
14 INT339099 ERBB2 Positive_regulation of IGF2R 1 0.33 0.67 0.06 5.00
15 INT122480 Binding of SERPINE1 and PLAU 4 0.40 2.75 0.06 5.00
16 INT339105 ERBB2 Positive_regulation of EGFR 1 0.37 0.68 0.06 5.00
17 INT339110 ERBB2 Positive_regulation of GATA6 1 0.31 0.67 0.06 5.00
18 INT339112 Binding of ERBB2 and TAB2 1 0.00 0.05 0.04 5.00
19 INT339113 Binding of ASIP and ERBB2 1 0.00 0.64 0 5.00
20 INT339104 Binding of ERBB2 and GRB7 1 0.30 1.29 0 5.00
21 INT197043 Positive_regulation of Binding of PLAU and BCAS1 1 0.05 1.01 0 5.00
22 INT339107 Binding of BCS1L and PAK1 1 0.01 0.08 0 5.00
23 INT339117 Binding of EGFR and GRB7 1 0.28 1.18 0 5.00
24 INT192328 UBR7 Regulation of Phosphorylation of PDGFA 1 0.00 0 0 5.00
25 INT339102 Binding of ESR1 and PVT1 1 0.34 0.3 0 5.00
26 INT197044 Binding of FBN1 and PLAU 1 0.02 0.44 0 5.00
27 INT339118 Binding of MYC and PVT1 1 0.21 0.76 0 5.00
28 INT339115 Binding of ERBB2 and PVT1 1 0.43 1.11 0 5.00
29 INT339098 Binding of ESR1 and TRPS1 1 0.30 0.3 0 5.00
30 INT339103 Binding of ERBB2 and TRPS1 1 0.39 0.3 0 5.00
31 INT339109 Binding of BCS1L and GDPD4 1 0.02 0.08 0 5.00
32 INT339106 Binding of BCS1L and ERBB2 1 0.04 0.17 0 5.00
33 INT197041 Binding of BCS1L and PLAU 1 0.16 0.44 0 5.00
34 INT339100 Binding of ASIP and EGFR 1 0.00 0.58 0 5.00
35 INT339114 Binding of ERBB2 and MYC 1 0.22 0.81 0 5.00
36 INT197042 Binding of PLAU and BCAS1 1 0.04 1.01 0 5.00
37 INT339120 Binding of ERBB2 and MIEN1 1 0.31 0.42 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Second Primary Neoplasms. They are ordered first by their pain relevance and then by number of times they were reported in Second Primary Neoplasms. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT206198 Negative_regulation of ESRRG 1 0.18 6.21 0 99.06
2 INT745 Gene_expression of Afp 65 0.78 52.89 4.24 99.06
3 INT206199 Gene_expression of ESRRG 1 0.20 0.85 0 99.06
4 INT70134 Negative_regulation of TXK 124 0.23 81.96 9.59 98.44
5 INT202203 Positive_regulation of GSTT1 4 0.47 1.26 0 98.28
6 INT69561 Positive_regulation of GSTM1 23 0.50 5.69 6.36 97.88
7 INT6624 Gene_expression of Pth 135 0.76 110.27 27.54 97.80
8 INT86219 Negative_regulation of GSTK1 25 0.41 8.99 4.97 93.40
9 INT115370 Gene_expression of PSIP1 22 0.65 9.45 5.68 93.00
10 INT115369 Positive_regulation of Gene_expression of PSIP1 4 0.49 4.92 1.88 93.00
11 INT11634 Regulation of SERPINE1 24 0.62 20.06 4.26 90.80
12 INT113565 Regulation of PLAU 6 0.58 5.8 0.66 90.80
13 INT11354 Regulation of Gene_expression of SERPINE1 11 0.61 8.66 4.42 90.80
14 INT11364 Regulation of Gene_expression of PLAU 4 0.58 3.23 1.92 90.80
15 INT11359 Gene_expression of PLAU 84 0.76 49.54 12.31 90.44
16 INT11361 Gene_expression of SERPINE1 183 0.78 136.45 27.97 90.12
17 INT16323 Gene_expression of pr 62 0.66 36.14 38.26 80.72
18 INT36798 Gene_expression of Mki67 178 0.77 132 8.24 80.72
19 INT69435 Negative_regulation of ROS1 74 0.51 50.38 13.71 80.52
20 INT1706 Negative_regulation of PCa 33 0.47 10.7 15.27 80.48
21 INT164756 Negative_regulation of PDGFRB 32 0.57 21.69 0.72 76.48
22 INT8669 Positive_regulation of Afp 66 0.70 58.21 7.67 73.76
23 INT15046 Positive_regulation of Gene_expression of Afp 6 0.46 5.95 0.52 73.76
24 INT8801 Gene_expression of Csf3 71 0.74 45.6 10.83 72.24
25 INT78202 Binding of GSTK1 17 0.31 5.44 1.66 67.84
26 INT59891 Positive_regulation of GSTK1 46 0.67 17.66 5.33 67.40
27 INT60542 Positive_regulation of Gene_expression of GSTK1 11 0.39 6.21 1.13 67.40
28 INT57645 Gene_expression of GSTK1 54 0.62 21.05 4.2 67.04
29 INT74563 Positive_regulation of Gene_expression of ROS1 258 0.61 168.18 34.08 62.00
30 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83 61.56
31 INT112003 Localization of ROS1 94 0.73 66.32 12.16 61.56
32 INT195206 Binding of BCC1 15 0.41 21.3 0.62 58.80
33 INT197045 Gene_expression of PPIB 6 0.70 2.32 0.05 58.44
34 INT70265 Regulation of MRI1 42 0.39 30.95 14.18 55.36
35 INT232465 Positive_regulation of ZMYND10 4 0.67 2.07 0.71 55.36
36 INT13510 Gene_expression of ERBB2 530 0.78 405.68 16.79 51.60
37 INT11159 Gene_expression of EGFR 698 0.78 548.93 25.69 51.60
38 INT49128 Gene_expression of IGF1R 35 0.63 23.48 1.39 51.60
39 INT339156 Gene_expression of FOXA1 1 0.33 9.37 0.23 51.60
40 INT106022 Negative_regulation of GSTP1 5 0.59 2.12 0.55 49.20
41 INT28872 Positive_regulation of CSRP1 49 0.70 47.23 11.7 44.36
42 INT50268 Gene_expression of FBN1 13 0.65 10.73 2.72 40.68
43 INT157846 Gene_expression of BCS1L 13 0.50 15.89 0.83 40.68
44 INT87406 Gene_expression of GSTP1 16 0.77 11.37 0.35 34.80
45 INT120767 Negative_regulation of Gene_expression of GSTP1 3 0.42 1.15 0.09 34.80
46 INT284764 Positive_regulation of Transcription of BCC1 1 0.42 1.58 0 33.08
47 INT63905 Regulation of RB1 13 0.62 12.67 1.28 32.72
48 INT284767 Transcription of BCC1 1 0.57 1.58 0 32.20
49 INT92388 Gene_expression of ALK 16 0.78 22.46 2.26 32.12
50 INT180264 Positive_regulation of BCC1 11 0.59 12.81 0.2 31.20
51 INT149031 Gene_expression of Tjp1 43 0.75 19.1 2.06 31.12
52 INT159141 Negative_regulation of Gene_expression of Tjp1 7 0.57 5.44 0.62 31.12
53 INT131378 Negative_regulation of FN1 20 0.35 33.98 5.85 28.60
54 INT38672 Binding of KRT20 69 0.39 48.01 6.31 26.08
55 INT131931 Binding of KRT7 13 0.36 19.24 0.5 26.08
56 INT274661 Positive_regulation of Binding of KRT7 1 0.45 3.5 0.15 26.08
57 INT274662 Positive_regulation of Binding of KRT20 3 0.39 4.32 0.15 26.08
58 INT5374 Gene_expression of Esr1 412 0.77 263.89 67.34 26.00
59 INT53475 Gene_expression of MRI1 116 0.59 77.68 33.98 25.60
60 INT105884 Binding of Bcl2 19 0.35 15.67 3 20.76
61 INT86672 Negative_regulation of Bcl2 50 0.53 34.16 8.37 14.56
62 INT11357 Negative_regulation of Gene_expression of PLAU 10 0.56 5.3 2.38 13.64
63 INT48722 Negative_regulation of Gene_expression of SERPINE1 12 0.43 7.66 1.85 13.64
64 INT334692 Localization of Igf1r 1 0.09 0.89 0.03 11.92
65 INT16321 Gene_expression of Cd3e 111 0.72 49.9 14.21 9.76
66 INT15054 Gene_expression of Mme 48 0.77 42.52 10.63 9.76
67 INT190935 Gene_expression of Cd5 2 0.25 3.02 0.04 9.76
68 INT177586 Positive_regulation of Gene_expression of MRI1 9 0.33 4.97 2.91 9.68
69 INT28361 Gene_expression of TP53 443 0.78 384.86 28.8 9.28
70 INT139556 Positive_regulation of Chrna4 10 0.25 4.52 2.36 5.60
71 INT14737 Gene_expression of FN1 117 0.78 78.74 18.99 5.40
72 INT1912 Gene_expression of Calca 1152 0.78 453.25 739.84 5.00
73 INT49750 Negative_regulation of CPOX 735 0.58 360.06 274.19 5.00
74 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
75 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 5.00
76 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 5.00
77 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 5.00
78 INT48408 Gene_expression of ICAM1 494 0.78 340.08 88.6 5.00
79 INT39565 Gene_expression of Ptger2 424 0.75 229.28 72.68 5.00
80 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 5.00
81 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64 5.00
82 INT73048 Gene_expression of MMP9 268 0.77 159.75 57.81 5.00
83 INT82650 Gene_expression of Bcl2 312 0.78 211.71 55.03 5.00
84 INT26500 Gene_expression of MMP2 201 0.78 110.57 46.9 5.00
85 INT71786 Phosphorylation of MAPK1 256 0.82 110.09 46.17 5.00
86 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53 5.00
87 INT69437 Positive_regulation of ROS1 328 0.58 222.83 40.56 5.00
88 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 5.00
89 INT9082 Positive_regulation of ESR1 238 0.69 148.51 36.69 5.00
90 INT10248 Gene_expression of KRT20 436 0.78 231.96 32.88 5.00
91 INT62830 Gene_expression of VCAM1 149 0.78 125.23 32.4 5.00
92 INT83708 Negative_regulation of MAPK1 156 0.57 84.93 27.85 5.00
93 INT20462 Binding of ESR1 210 0.44 102.7 26.34 5.00
94 INT823 Negative_regulation of ESR1 144 0.58 63.72 22.52 5.00
95 INT93734 Positive_regulation of Gene_expression of Bcl2 76 0.70 61.95 18.46 5.00
96 INT116950 Negative_regulation of MAPK8 103 0.57 44.48 17.53 5.00
97 INT4067 Negative_regulation of Esr1 97 0.50 43.45 17.52 5.00
98 INT32515 Negative_regulation of B4GALNT1 82 0.43 28.1 17.46 5.00
99 INT86673 Positive_regulation of Bcl2 77 0.70 57.74 17.37 5.00
100 INT65856 Positive_regulation of TP53 138 0.67 112.65 16.71 5.00
101 INT109929 Phosphorylation of MAPK8 102 0.81 39.98 16.54 5.00
102 INT108780 Positive_regulation of Gene_expression of Ptger2 94 0.49 59.71 16.22 5.00
103 INT92354 Localization of ESR1 77 0.75 33.04 15.51 5.00
104 INT170855 Negative_regulation of GOPC 188 0.38 70.92 15.41 5.00
105 INT109535 Gene_expression of Vegfa 116 0.75 84.61 14.89 5.00
106 INT11636 Positive_regulation of SERPINE1 85 0.69 68.73 14.8 5.00
107 INT42979 Positive_regulation of INSRR 47 0.32 12.24 14.38 5.00
108 INT94774 Regulation of CDKN2A 43 0.60 44.41 13.99 5.00
109 INT18012 Gene_expression of EPO 169 0.78 108.36 13.75 5.00
110 INT78472 Gene_expression of CDKN2A 223 0.78 173.76 13.61 5.00
111 INT86383 Negative_regulation of EGFR 258 0.59 173.94 13.32 5.00
112 INT27242 Gene_expression of PGR 153 0.75 98.77 12.79 5.00
113 INT158124 Gene_expression of COL5A2 136 0.69 72.3 12.44 5.00
114 INT8547 Gene_expression of MUC16 116 0.78 75.97 12.18 5.00
115 INT79545 Positive_regulation of Gene_expression of ESR1 82 0.64 39.42 12.18 5.00
116 INT19795 Positive_regulation of EGFR 161 0.70 103.69 11.55 5.00
117 INT8546 Positive_regulation of MUC16 99 0.69 74.98 11.26 5.00
118 INT2378 Negative_regulation of SERPINE1 47 0.59 34.55 9.9 5.00
119 INT33099 Negative_regulation of INSRR 32 0.40 13.82 9.85 5.00
120 INT64346 Positive_regulation of S100B 95 0.70 63.11 9.17 5.00
121 INT44378 Gene_expression of GSTM1 69 0.76 34.61 8.81 5.00
122 INT113845 Protein_catabolism of PARP1 54 0.88 43.86 8.77 5.00
123 INT8903 Gene_expression of IFNA2 58 0.71 38.23 8.68 5.00
124 INT70896 Gene_expression of PDGFB 48 0.65 33.55 8.39 5.00
125 INT15687 Regulation of ESR1 91 0.60 40.42 7.95 5.00
126 INT32210 Gene_expression of Mif 13 0.75 28.48 7.79 5.00
127 INT111607 Gene_expression of CDH1 103 0.75 90.45 7.77 5.00
128 INT1150 Gene_expression of ecs 42 0.59 29.38 7.73 5.00
129 INT93607 Binding of CHPT1 8 0.32 5.93 7.58 5.00
130 INT78320 Gene_expression of EPCAM 57 0.75 50.34 7.53 5.00
131 INT57748 Positive_regulation of Gene_expression of TP53 85 0.69 79.55 7.49 5.00
132 INT91445 Regulation of Bcl2 50 0.56 38.8 7.41 5.00
133 INT48626 Positive_regulation of Csf3 33 0.66 29.79 7.34 5.00
134 INT14732 Positive_regulation of FN1 46 0.69 31.17 7.33 5.00
135 INT96994 Phosphorylation of EGFR 99 0.82 52.75 7.33 5.00
136 INT91509 Localization of CYC1 39 0.78 34.74 7.17 5.00
137 INT88079 Gene_expression of Chrna4 20 0.76 8.52 6.98 5.00
138 INT95117 Gene_expression of PDGFA 71 0.71 51.17 6.9 5.00
139 INT93101 Regulation of Gene_expression of Bcl2 26 0.62 18.45 6.71 5.00
140 INT60700 Gene_expression of Itgax 93 0.71 51.89 6.57 5.00
141 INT185879 Gene_expression of CDC6 9 0.39 5.18 6.46 5.00
142 INT29561 Binding of GSTM1 35 0.48 25.86 6.24 5.00
143 INT79425 Gene_expression of SMN1 42 0.65 36.37 6.1 5.00
144 INT9779 Gene_expression of Glb1 23 0.58 8.01 6.04 5.00
145 INT134346 Binding of PCS 51 0.37 22.27 5.67 5.00
146 INT11360 Localization of SERPINE1 41 0.80 33.98 5.61 5.00
147 INT105960 Gene_expression of Cdh1 41 0.76 22.28 5.56 5.00
148 INT125467 Positive_regulation of Gene_expression of CDKN2A 35 0.63 39.07 5.56 5.00
149 INT15376 Positive_regulation of Gene_expression of ERBB2 215 0.70 168.54 5.23 5.00
150 INT60585 Regulation of TP53 59 0.59 54.55 5.21 5.00
151 INT24080 Negative_regulation of Mtor 64 0.37 41.56 5.19 5.00
152 INT128161 Gene_expression of DDIT3 20 0.75 17.14 5.13 5.00
153 INT11158 Positive_regulation of Gene_expression of EGFR 165 0.70 131.26 4.93 5.00
154 INT20121 Negative_regulation of CYBB 34 0.54 15.5 4.44 5.00
155 INT26404 Positive_regulation of ATM 15 0.49 10.94 4.39 5.00
156 INT101957 Transcription of Bcl2 30 0.69 16.57 4.3 5.00
157 INT10374 Gene_expression of RARA 39 0.75 22.59 4.28 5.00
158 INT11635 Positive_regulation of Gene_expression of SERPINE1 35 0.68 24.57 4.26 5.00
159 INT57273 Positive_regulation of Gene_expression of FN1 26 0.47 17.83 4.2 5.00
160 INT21681 Positive_regulation of CD34 54 0.66 33.95 4.14 5.00
161 INT110181 Negative_regulation of Phosphorylation of MAPK8 20 0.57 9.43 4.06 5.00
162 INT10992 Gene_expression of PARP1 32 0.76 22.22 3.74 5.00
163 INT19491 Gene_expression of CD19 44 0.75 28.8 3.47 5.00
164 INT163832 Negative_regulation of Gene_expression of EGFR 50 0.59 39.71 3.45 5.00
165 INT60541 Regulation of GSTK1 12 0.61 6.76 3.31 5.00
166 INT22375 Localization of PDGFA 21 0.75 15.46 3.25 5.00
167 INT61500 Binding of FN1 39 0.48 27.33 3.13 5.00
168 INT53065 Negative_regulation of Gene_expression of EPO 15 0.49 16.39 3.12 5.00
169 INT96542 Negative_regulation of SMN1 14 0.51 10.72 3.11 5.00
170 INT24926 Regulation of Csf3 17 0.52 10.41 3.04 5.00
171 INT19335 Positive_regulation of CYC1 11 0.67 9.82 2.92 5.00
172 INT133080 Gene_expression of GATA3 15 0.61 5.64 2.89 5.00
173 INT27652 Gene_expression of TG 36 0.78 22.36 2.74 5.00
174 INT126454 Gene_expression of Msln 15 0.55 11.82 2.63 5.00
175 INT67884 Positive_regulation of PLAU 15 0.68 11.21 2.61 5.00
176 INT136093 Regulation of FBN1 10 0.14 4.39 2.52 5.00
177 INT15187 Positive_regulation of Gene_expression of Csf3 17 0.66 10.97 2.51 5.00
178 INT15540 Positive_regulation of PDGFA 24 0.47 19.01 2.5 5.00
179 INT96876 Gene_expression of AHR 20 0.77 10.43 2.39 5.00
180 INT192337 Positive_regulation of DDR1 11 0.41 10.34 2.38 5.00
181 INT22679 Binding of SERPINE1 25 0.36 17.33 2.36 5.00
182 INT25208 Gene_expression of IGF2 43 0.74 30.64 2.31 5.00
183 INT83236 Localization of PGR 14 0.73 8.26 2.23 5.00
184 INT40565 Gene_expression of SLPI 15 0.75 7.25 2.21 5.00
185 INT163545 Gene_expression of PDGFRB 39 0.78 25.5 2.2 5.00
186 INT76304 Positive_regulation of Zap70 5 0.67 1.43 2.19 5.00
187 INT85085 Positive_regulation of KIT 36 0.53 30.08 2.17 5.00
188 INT37394 Localization of ecs 9 0.34 6.41 2.11 5.00
189 INT48444 Localization of Csf3 28 0.72 14.85 2.11 5.00
190 INT169705 Negative_regulation of Gene_expression of Cdh1 10 0.57 8.8 2.1 5.00
191 INT108335 Phosphorylation of EGF 17 0.80 7.3 2.09 5.00
192 INT177778 Gene_expression of SQLE 28 0.40 16.42 2.08 5.00
193 INT123253 Localization of Chrna4 4 0.44 1.31 1.99 5.00
194 INT173851 Localization of FN1 20 0.76 13.95 1.97 5.00
195 INT117934 Gene_expression of Cd38 11 0.68 6.5 1.95 5.00
196 INT57272 Negative_regulation of Gene_expression of FN1 16 0.43 11.42 1.93 5.00
197 INT11033 Positive_regulation of Gene_expression of MUC16 21 0.69 15.75 1.89 5.00
198 INT56925 Negative_regulation of TSC1 54 0.52 63.39 1.87 5.00
199 INT136503 Negative_regulation of KDR 46 0.48 43.1 1.86 5.00
200 INT48792 Regulation of ERBB2 48 0.57 36.56 1.8 5.00
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