D:Secondary Adrenal Insufficiency

Disease Term Synonyms Acth Deficiency Documents 19 Hot Single Events 15 Hot Interactions 1

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Secondary Adrenal Insufficiency. They are ordered first by their relevance to Secondary Adrenal Insufficiency and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No	Page link	Interaction String	Documents	TM Confidence	Disease Relevance	Overall Pain Relevance	Term Relevance
1	INT6131	INSIG1 Positive_regulation of POMC	1	0.06	0.61	0	80.44
2	INT179237	Binding of SERPINA6 and POMC	1	0.03	1.15	0.49	5.00
3	INT179233	IRF6 Negative_regulation of Binding of GSR	1	0.03	0.83	0.25	5.00
4	INT179230	Binding of MAPK14 and GSR	1	0.03	0.5	0.23	5.00
5	INT179229	Binding of GSR and NR3C2	1	0.03	0.37	0.23	5.00
6	INT179234	Binding of SERPINA6 and ELANE	1	0.01	0.22	0.12	5.00
7	INT179232	Binding of CREM and GSR	1	0.00	0	0.06	5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Secondary Adrenal Insufficiency. They are ordered first by their pain relevance and then by number of times they were reported in Secondary Adrenal Insufficiency. Please click on the 'INT' link to display more detailed information on each interaction.

Int No	Page link	Event String	Documents	TM Confidence	Disease Relevance	Overall Pain Relevance	Term Relevance
1	INT739	Negative_regulation of POMC	358	0.59	102.28	166.77	99.84
2	INT50405	Negative_regulation of CYP3A4	238	0.59	53.65	51.51	99.76
3	INT738	Regulation of POMC	459	0.62	111.19	243.74	99.12
4	INT467	Gene_expression of POMC	1048	0.78	332.8	394.16	98.92
5	INT6947	Negative_regulation of Gene_expression of POMC	37	0.59	10.32	14.14	98.92
6	INT7082	Gene_expression of CRH	180	0.78	64.66	31.74	98.92
7	INT2144	Localization of COL7A1	36	0.74	20.92	4.67	94.24
8	INT1197	Negative_regulation of Localization of POMC	109	0.59	28.29	48.02	92.00
9	INT5454	Localization of CRH	124	0.79	79.18	41.53	91.32
10	INT443	Localization of POMC	1020	0.81	284.52	443.17	90.84
11	INT38686	Binding of NR3C1	20	0.48	9.25	5.99	85.24
12	INT16868	Gene_expression of Il6	807	0.78	499.48	256.57	85.04
13	INT52818	Localization of NR3C1	13	0.69	7.65	4.57	84.24
14	INT682	Negative_regulation of AVP	97	0.59	50.67	23.91	81.36
15	INT6132	Regulation of INSIG1	1	0.03	1.23	0	80.84
16	INT3118	Negative_regulation of Positive_regulation of POMC	33	0.59	9.42	18.07	79.60
17	INT50579	Binding of CYP3A4	84	0.48	17.52	17.45	75.00
18	INT163259	Positive_regulation of Tpo	1	0.14	1.16	0.17	69.04
19	INT720	Positive_regulation of POMC	807	0.70	237.37	353.83	66.32
20	INT170886	Gene_expression of AIRE	2	0.49	4.63	0.19	64.72
21	INT812	Localization of INS	1026	0.81	515.6	145.31	59.12
22	INT63057	Regulation of CYP3A4	31	0.61	5.75	6.92	50.00
23	INT6129	Positive_regulation of Localization of AVP	63	0.70	30.44	16.64	42.80
24	INT1196	Positive_regulation of Positive_regulation of POMC	51	0.70	15.99	28.58	42.20
25	INT214	Localization of AVP	370	0.81	208.51	91.09	41.12
26	INT115963	Negative_regulation of Gene_expression of CRH	9	0.59	4.53	1.48	28.28
27	INT9408	Positive_regulation of Crp	296	0.69	242.27	57.35	25.32
28	INT48593	Positive_regulation of NOS1	420	0.68	226.15	114.71	23.12
29	INT9660	Regulation of TNF	363	0.62	312.94	139.99	20.56
30	INT11288	Negative_regulation of CRH	44	0.00	16.69	12.37	18.32
31	INT9235	Negative_regulation of Gene_expression of TNF	346	0.59	252.98	118.61	16.44
32	INT6483	Gene_expression of TNF	3152	0.78	2515.62	929.82	16.20
33	INT695	Binding of POMC	304	0.48	56.66	126.85	14.84
34	INT63534	Binding of CRH	23	0.47	6.84	3.43	14.84
35	INT9238	Gene_expression of IL6	1575	0.78	1135.66	424.22	5.00
36	INT5059	Positive_regulation of TNF	1050	0.70	896.51	322.81	5.00
37	INT5972	Gene_expression of IL1B	948	0.78	510.91	263.97	5.00
38	INT6481	Binding of TNF	624	0.48	510.2	214.82	5.00
39	INT6482	Positive_regulation of Gene_expression of TNF	659	0.70	569.88	210	5.00
40	INT11051	Positive_regulation of Gene_expression of IL6	415	0.69	319.21	109.3	5.00
41	INT90091	Gene_expression of GOPC	967	0.67	366.22	103.6	5.00
42	INT11381	Positive_regulation of IL1B	330	0.70	209.31	100.9	5.00
43	INT6473	Positive_regulation of Gene_expression of IL1B	204	0.70	117.23	50.86	5.00
44	INT531	Gene_expression of GH1	376	0.75	193.45	46.24	5.00
45	INT1931	Positive_regulation of Gene_expression of POMC	116	0.70	37.26	38.67	5.00
46	INT3679	Gene_expression of AVP	171	0.78	72.9	35.23	5.00
47	INT10763	Localization of IL2	157	0.80	81.11	33.21	5.00
48	INT234	Binding of Alb	151	0.48	52.34	32.97	5.00
49	INT22045	Gene_expression of IRF6	158	0.75	58.07	27.81	5.00
50	INT703	Positive_regulation of Pth	177	0.70	127.09	27.26	5.00
51	INT2609	Localization of ELANE	111	0.81	50.22	26.63	5.00
52	INT3330	Gene_expression of AGT	149	0.76	98.65	22.73	5.00
53	INT5905	Negative_regulation of ELANE	113	0.59	47.43	22.09	5.00
54	INT8580	Gene_expression of ELANE	132	0.75	62.98	21.79	5.00
55	INT105021	Binding of GOPC	187	0.40	60.39	20.38	5.00
56	INT86187	Positive_regulation of AKT1	199	0.69	122.13	19.44	5.00
57	INT69158	Localization of IL4	48	0.71	31.3	11.98	5.00
58	INT170601	Positive_regulation of Gene_expression of GOPC	122	0.43	42.79	11.68	5.00
59	INT66606	Gene_expression of CXCR1	34	0.75	27.79	11.36	5.00
60	INT3845	Gene_expression of GSR	79	0.76	44.69	11.19	5.00
61	INT3846	Positive_regulation of GSR	60	0.50	35.16	9.37	5.00
62	INT52924	Negative_regulation of GSR	49	0.58	28.08	9.28	5.00
63	INT44550	Positive_regulation of Gene_expression of AVP	38	0.70	22.27	8.62	5.00
64	INT6625	Negative_regulation of Pth	96	0.58	57.6	8.24	5.00
65	INT132822	Localization of IL13	26	0.67	22.85	6.66	5.00
66	INT76096	Positive_regulation of Gene_expression of IRF6	37	0.49	14.24	6.39	5.00
67	INT57502	Positive_regulation of Gene_expression of CRH	30	0.70	23.37	5.7	5.00
68	INT29138	Positive_regulation of Localization of IL2	25	0.50	10.06	3.89	5.00
69	INT179261	Gene_expression of SERPINA6	12	0.14	3.53	3.82	5.00
70	INT26233	Binding of GSR	45	0.46	18.22	3.74	5.00
71	INT69155	Positive_regulation of Localization of IL4	13	0.40	10.18	3.56	5.00
72	INT91070	Regulation of GSR	27	0.59	16.64	3.42	5.00
73	INT83351	Positive_regulation of Gene_expression of GSR	15	0.64	12.03	2.97	5.00
74	INT173179	Binding of MAPK14	13	0.29	4.51	2.92	5.00
75	INT79658	Transcription of GSR	8	0.68	3.59	2.19	5.00
76	INT179256	Positive_regulation of Localization of IL13	7	0.42	7.04	2.14	5.00
77	INT179257	Binding of SERPINA6	5	0.10	2.09	1.24	5.00
78	INT177629	Negative_regulation of SERPINA6	5	0.57	2.1	1.22	5.00
79	INT110582	Localization of GSR	10	0.79	4.03	1.19	5.00
80	INT179262	Localization of SERPINA6	4	0.16	1.29	1.1	5.00
81	INT76757	Positive_regulation of SERPINA6	3	0.59	1.19	0.97	5.00
82	INT160056	Positive_regulation of AKT2	3	0.48	1.43	0.88	5.00
83	INT83353	Negative_regulation of Binding of NR3C1	3	0.24	1.09	0.57	5.00
84	INT179248	Positive_regulation of Positive_regulation of GSR	3	0.40	4.65	0.56	5.00
85	INT83349	Negative_regulation of Binding of GSR	3	0.39	1.48	0.49	5.00
86	INT177628	Protein_catabolism of SERPINA6	2	0.96	1.2	0.42	5.00
87	INT179227	Positive_regulation of Crisp1	3	0.45	1.15	0.3	5.00
88	INT34058	Gene_expression of FMR1	5	0.75	5.11	0.26	5.00
89	INT179228	Localization of Crisp1	2	0.73	0.9	0.2	5.00
90	INT179250	Negative_regulation of Transcription of GSR	2	0.56	1.7	0.18	5.00
91	INT179247	Negative_regulation of Localization of GSR	1	0.24	0.65	0.18	5.00
92	INT179260	Binding of AKT2	2	0.27	1.8	0.15	5.00
93	INT179259	Negative_regulation of Localization of SERPINA6	1	0.08	0.5	0.13	5.00
94	INT179253	Regulation of SERPINA6	1	0.06	0.57	0.12	5.00
95	INT179252	Localization of CYP11A1	1	0.07	0.83	0.1	5.00
96	INT99034	Negative_regulation of CYP11A1	2	0.41	0.92	0.1	5.00
97	INT179255	Negative_regulation of Localization of CYP11A1	1	0.04	0.84	0.1	5.00
98	INT180359	Localization of AIRE	3	0.54	3.94	0.03	5.00