D:Secondary Pulmonary Hypertension

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Disease Term
Synonyms Ayerza Arrilaga Syndrome, Ayerza S Syndrome, Ayerza Syndrome, AYERZAS SYNDROME, HYPERTENSION PULMONARY, PULMONARY HYPERTENSION, Secondary Pulmonary Artery Hypertension, Secondary Pulmonary Hypertensions, Spah, SYNDROME AYERZA, Syndrome Ayerza Arrilaga
Documents 19
Hot Single Events 24
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Secondary Pulmonary Hypertension. They are ordered first by their relevance to Secondary Pulmonary Hypertension and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT286901 Binding of HBM and VEGFA 1 0.05 1.08 0.14 75.52
2 INT286900 Binding of HBM and PDGFA 1 0.04 1.08 0.14 75.52
3 INT286898 Binding of HBM and IL6 1 0.01 1.09 0.14 75.52
4 INT286902 Binding of PDGFA and VEGFA 1 0.24 1.1 0 73.36
5 INT183781 Binding of IL6 and INS 6 0.22 8.97 1.87 10.40
6 INT121651 Binding of CXCL12 and CXCR4 13 0.48 17.61 3.52 5.00
7 INT254355 PF4 Positive_regulation of IFNA1 1 0.04 1.23 1.26 5.00
8 INT254352 Binding of CXCR4 and Positive_regulation of Gene_expression of CXCL12 1 0.14 1.8 0.66 5.00
9 INT254356 Binding of IFNG and IL1B 1 0.00 1.87 0.51 5.00
10 INT254357 Binding of IFNA1 and IL1B 1 0.00 1.88 0.51 5.00
11 INT254348 Binding of ANGPT1 and TEK 1 0.04 1.72 0.48 5.00
12 INT254360 Binding of EPAS1 and HIF1A 3 0.39 3.36 0.46 5.00
13 INT230437 Binding of PDX1 and HRCT1 1 0.04 2.45 0.43 5.00
14 INT254347 FASLG Negative_regulation of Gene_expression of CHI3L1 1 0.13 0.92 0.42 5.00
15 INT254350 FASLG Negative_regulation of Gene_expression of VEGFA 1 0.06 0.92 0.42 5.00
16 INT273617 Gene_expression of Slc6a4 Positive_regulation of Pah 1 0.02 0.93 0.38 5.00
17 INT230438 Binding of PDX1 and HAUS7 1 0.02 2.29 0.35 5.00
18 INT254353 Binding of VEGFA and MMRN1 1 0.00 0.81 0.28 5.00
19 INT254359 IL1B Positive_regulation of Localization of VEGFA 1 0.01 0.87 0.26 5.00
20 INT254349 Positive_regulation of Binding of EPAS1 and HIF1A 1 0.00 0.92 0.23 5.00
21 INT254351 Binding of ANGPT2 and TEK 1 0.04 0.87 0.22 5.00
22 INT286899 Binding of IL6 and CCL2 1 0.03 0.92 0.08 5.00
23 INT273616 PVR Positive_regulation of Pah 1 0.10 0.86 0.07 5.00
24 INT256210 NPPB Regulation of PVR 1 0.24 1.14 0 5.00
25 INT171404 ISYNA1 Positive_regulation of Negative_regulation of Ppap2a 1 0.05 0.23 0 5.00
26 INT256209 AVP Regulation of PVR 1 0.06 0.99 0 5.00
27 INT256211 NPPB Regulation of PDAP1 1 0.28 1.14 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Secondary Pulmonary Hypertension. They are ordered first by their pain relevance and then by number of times they were reported in Secondary Pulmonary Hypertension. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT171060 Gene_expression of PDX1 72 0.75 72.57 17.97 100.00
2 INT183065 Positive_regulation of Gene_expression of PDX1 7 0.54 6.58 1.29 100.00
3 INT9210 Regulation of IL6 166 0.62 125.61 49.95 99.36
4 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 99.24
5 INT68683 Regulation of Gene_expression of VEGFA 143 0.62 104.19 20.14 99.24
6 INT99688 Negative_regulation of Gene_expression of VEGFA 274 0.58 201.8 31.1 98.24
7 INT95118 Negative_regulation of Gene_expression of PDGFA 4 0.54 5.03 0.76 98.24
8 INT95117 Gene_expression of PDGFA 71 0.71 51.17 6.9 97.52
9 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 95.60
10 INT45342 Binding of AVSD1 6 0.31 7.23 0.27 95.44
11 INT188317 Positive_regulation of Gene_expression of PDGFA 15 0.46 12.7 0.91 94.96
12 INT68681 Transcription of VEGFA 132 0.71 80.47 17.03 94.88
13 INT15540 Positive_regulation of PDGFA 24 0.47 19.01 2.5 93.96
14 INT130176 Positive_regulation of Gene_expression of CRP 125 0.66 137.06 25.9 92.80
15 INT133214 Regulation of PDX1 9 0.34 10.26 3.36 92.00
16 INT53500 Negative_regulation of Ppap2a 11 0.45 3.31 1.92 92.00
17 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 91.48
18 INT19541 Gene_expression of Ptgir 22 0.65 15.42 5.39 91.36
19 INT11051 Positive_regulation of Gene_expression of IL6 415 0.69 319.21 109.3 87.56
20 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 87.16
21 INT171402 Positive_regulation of Positive_regulation of Ppap2a 4 0.36 0.81 0.04 85.44
22 INT17879 Positive_regulation of Ppap2a 17 0.53 9.72 3.8 85.04
23 INT10838 Positive_regulation of IL8 381 0.70 295.51 101.62 80.92
24 INT73502 Positive_regulation of IL10 154 0.69 124.87 43.5 80.32
25 INT48692 Binding of VEGFA 345 0.48 210.3 21.31 75.76
26 INT1149 Binding of ecs 19 0.37 13.67 3.9 74.56
27 INT210390 Binding of PDGFA 12 0.36 6.78 0.63 73.36
28 INT242346 Negative_regulation of Positive_regulation of PDAP1 2 0.45 2.43 0.15 73.00
29 INT22429 Positive_regulation of PDAP1 34 0.61 22.58 2.91 72.04
30 INT254372 Negative_regulation of TEK 1 0.12 1.05 0.31 68.24
31 INT79598 Regulation of PDE5A 16 0.60 8.68 1.17 68.20
32 INT143230 Gene_expression of CRYGD 61 0.65 52.11 15.93 64.32
33 INT254367 Transcription of TEK 1 0.14 1.08 0.36 62.56
34 INT230440 Gene_expression of HAUS7 1 0.04 4.13 1.02 60.80
35 INT60526 Gene_expression of IL10 449 0.78 292.71 107.84 58.88
36 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 57.36
37 INT9234 Negative_regulation of Gene_expression of IL6 171 0.59 101.61 53.15 46.56
38 INT15746 Negative_regulation of PDAP1 13 0.52 6.45 1.12 41.56
39 INT100861 Binding of CRP 179 0.48 175.2 26.45 40.32
40 INT3128 Negative_regulation of PON1 30 0.59 26.19 4.57 36.68
41 INT3723 Binding of PON1 9 0.46 5.83 2.13 36.28
42 INT53502 Regulation of Ppap2a 6 0.34 1.42 0.32 34.96
43 INT103095 Binding of ISYNA1 10 0.28 6.17 2.03 32.96
44 INT171403 Regulation of Binding of ISYNA1 1 0.05 0.15 0 32.96
45 INT41892 Gene_expression of HBM 48 0.64 28.32 5.64 32.72
46 INT149138 Binding of PDX1 27 0.37 32.62 9.33 21.60
47 INT171058 Negative_regulation of PDX1 5 0.32 9.31 2.72 20.16
48 INT205998 Binding of PDAP1 3 0.33 2.66 0.03 16.80
49 INT211830 Binding of PVR 3 0.32 2.26 0.03 16.40
50 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 11.76
51 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 11.36
52 INT76336 Negative_regulation of PDE5A 192 0.59 112.02 20.09 10.80
53 INT61680 Positive_regulation of PVR 23 0.60 23.27 3.86 7.24
54 INT62124 Gene_expression of NOS1 444 0.78 218.08 114.85 5.00
55 INT1635 Gene_expression of Vip 245 0.78 53.36 88.13 5.00
56 INT56298 Gene_expression of IL4 306 0.78 182.18 72.92 5.00
57 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 5.00
58 INT46637 Gene_expression of CXCL10 172 0.78 121.94 57.74 5.00
59 INT4216 Gene_expression of CD40LG 328 0.78 256.02 44.23 5.00
60 INT101992 Localization of VEGFA 413 0.81 258.23 36.15 5.00
61 INT3679 Gene_expression of AVP 171 0.78 72.9 35.23 5.00
62 INT8905 Gene_expression of EDN1 215 0.78 157.1 34.19 5.00
63 INT73498 Gene_expression of IL13 117 0.44 83.85 32.26 5.00
64 INT86437 Binding of IL6 154 0.48 121.22 29.3 5.00
65 INT17825 Gene_expression of Flvcr2 44 0.68 12.58 28.08 5.00
66 INT7894 Negative_regulation of Vip 59 0.59 11.76 27.36 5.00
67 INT76095 Positive_regulation of ISYNA1 117 0.55 79.73 25.86 5.00
68 INT76743 Gene_expression of Slc6a4 55 0.76 13.53 24.9 5.00
69 INT10835 Regulation of IL8 79 0.49 53.04 24.14 5.00
70 INT6726 Positive_regulation of Edn1 118 0.70 65.96 24.07 5.00
71 INT9079 Gene_expression of PPBP 52 0.75 31.2 21.52 5.00
72 INT79349 Gene_expression of Sert1 58 0.77 12.7 20.65 5.00
73 INT157463 Gene_expression of CX3CL1 55 0.62 69.05 19.75 5.00
74 INT5160 Localization of PTAFR 61 0.80 42.6 19.16 5.00
75 INT6728 Gene_expression of Ednra 43 0.65 13.41 17.38 5.00
76 INT116465 Gene_expression of Birc5 241 0.78 192.31 15.32 5.00
77 INT9191 Localization of EDN1 94 0.81 57.01 14.78 5.00
78 INT105387 Gene_expression of HIF1A 116 0.77 98.62 14.66 5.00
79 INT88544 Gene_expression of MMRN1 102 0.75 68.8 14.55 5.00
80 INT8904 Positive_regulation of Gene_expression of EDN1 66 0.70 65.4 14.42 5.00
81 INT20420 Gene_expression of MYC 99 0.75 49.32 14.36 5.00
82 INT91544 Gene_expression of CHI3L1 60 0.75 77.72 13.9 5.00
83 INT108485 Gene_expression of CXCL12 61 0.75 49.34 13.79 5.00
84 INT90909 Negative_regulation of Gene_expression of NOS1 44 0.55 23.83 12.47 5.00
85 INT92574 Gene_expression of CXCL5 51 0.78 24.87 11.89 5.00
86 INT176607 Gene_expression of Cx3cl1 27 0.75 19.51 11.32 5.00
87 INT157466 Gene_expression of CX3CR1 14 0.76 20.6 10.76 5.00
88 INT100379 Positive_regulation of HIF1A 69 0.69 57.31 10.4 5.00
89 INT94859 Negative_regulation of Pde5a 67 0.43 33.66 10.28 5.00
90 INT17824 Positive_regulation of Gene_expression of Flvcr2 15 0.41 6.66 10.23 5.00
91 INT10139 Positive_regulation of F13A1 64 0.56 44.75 9.69 5.00
92 INT55014 Positive_regulation of Ednrb 31 0.70 16.61 9.68 5.00
93 INT22965 Positive_regulation of Pah 42 0.61 41.41 8.84 5.00
94 INT131788 Positive_regulation of NPPB 87 0.67 86.1 8.81 5.00
95 INT6727 Positive_regulation of Ednra 27 0.64 18.75 8.71 5.00
96 INT18025 Binding of Pah 32 0.45 30.72 7.93 5.00
97 INT127691 Gene_expression of CXCL1 23 0.66 18.11 7.04 5.00
98 INT32783 Gene_expression of Pah 33 0.60 30.55 6.86 5.00
99 INT34767 Gene_expression of PTGIR 36 0.42 14.79 6.69 5.00
100 INT62950 Gene_expression of NPPB 73 0.75 65.91 6.54 5.00
101 INT78178 Gene_expression of Ednrb 21 0.75 7.1 6.37 5.00
102 INT117189 Binding of CXCR4 34 0.37 24.27 5.81 5.00
103 INT60776 Regulation of EDNRA 20 0.51 16.62 5.36 5.00
104 INT80038 Positive_regulation of Gene_expression of MYC 24 0.67 13.93 5.17 5.00
105 INT7298 Gene_expression of NPPA 35 0.70 18.23 4.76 5.00
106 INT17324 Negative_regulation of Plg 26 0.38 13.5 4.05 5.00
107 INT191807 Gene_expression of CD24 75 0.78 53.92 3.34 5.00
108 INT47949 Positive_regulation of ELOVL1 19 0.42 29.78 3.3 5.00
109 INT79345 Positive_regulation of Gene_expression of Sert1 8 0.58 2.98 3.26 5.00
110 INT127455 Positive_regulation of Gene_expression of Slc6a4 9 0.59 5.62 3.2 5.00
111 INT175262 Binding of SH2B2 18 0.36 22.85 3.18 5.00
112 INT131472 Regulation of Pde5a 11 0.42 6.95 3.06 5.00
113 INT105390 Positive_regulation of Gene_expression of HIF1A 27 0.49 26.3 2.88 5.00
114 INT129358 Gene_expression of ELOVL1 23 0.66 29.39 2.83 5.00
115 INT29651 Regulation of Pah 11 0.37 9.95 2.79 5.00
116 INT208588 Binding of CXCR2 11 0.48 6.43 2.68 5.00
117 INT72165 Gene_expression of CXCL6 8 0.52 4.76 2.6 5.00
118 INT257299 Binding of Pde5a 14 0.27 4.31 2.45 5.00
119 INT108482 Positive_regulation of Gene_expression of CXCL12 7 0.53 9.72 2.36 5.00
120 INT78177 Negative_regulation of Gene_expression of Ednrb 4 0.41 1.04 2.16 5.00
121 INT112364 Negative_regulation of HIF1A 22 0.57 16.95 2.13 5.00
122 INT153718 Gene_expression of ANGPT1 15 0.45 10.82 2.13 5.00
123 INT37394 Localization of ecs 9 0.34 6.41 2.11 5.00
124 INT11390 Gene_expression of PF4 5 0.65 3.09 2.07 5.00
125 INT10976 Negative_regulation of ENPP3 13 0.42 5.11 1.92 5.00
126 INT171059 Localization of PDX1 8 0.56 6.7 1.9 5.00
127 INT133269 Positive_regulation of PDX1 10 0.54 9.77 1.9 5.00
128 INT183450 Positive_regulation of GUCY2C 6 0.04 4.45 1.88 5.00
129 INT153719 Gene_expression of TEK 10 0.49 9.82 1.88 5.00
130 INT200223 Positive_regulation of EPAS1 21 0.17 21.95 1.7 5.00
131 INT119346 Positive_regulation of PTGIR 9 0.58 6.2 1.61 5.00
132 INT35132 Gene_expression of PDAP1 18 0.52 9.05 1.5 5.00
133 INT93956 Binding of HBM 20 0.35 8.86 1.48 5.00
134 INT273613 Negative_regulation of PVR 7 0.17 5.06 1.26 5.00
135 INT210392 Regulation of PDGFA 10 0.36 11.41 1.12 5.00
136 INT28929 Negative_regulation of PVR 22 0.57 16.64 1.07 5.00
137 INT127459 Negative_regulation of PAH 18 0.56 15.15 1.05 5.00
138 INT254370 Gene_expression of THBS2 1 0.06 2.24 1 5.00
139 INT129971 Regulation of PVR 5 0.60 3.96 0.97 5.00
140 INT213722 Positive_regulation of PVR 3 0.25 2.4 0.94 5.00
141 INT36978 Localization of Pah 9 0.73 7.43 0.82 5.00
142 INT128889 Regulation of Gene_expression of Ptgir 3 0.51 2.38 0.81 5.00
143 INT30314 Negative_regulation of Ptgir 3 0.34 1.08 0.76 5.00
144 INT246524 Binding of QPCT 4 0.05 3.65 0.72 5.00
145 INT22385 Positive_regulation of Ptgir 8 0.41 5.16 0.71 5.00
146 INT254369 Negative_regulation of COL18A1 2 0.16 1.61 0.61 5.00
147 INT254368 Gene_expression of XCR1 1 0.20 1.03 0.55 5.00
148 INT142006 Positive_regulation of COL18A1 2 0.41 3.01 0.53 5.00
149 INT126442 Negative_regulation of Gene_expression of Ednra 3 0.33 1.94 0.51 5.00
150 INT240020 Regulation of Binding of IL6 4 0.36 4.38 0.46 5.00
151 INT202424 Gene_expression of HRCT1 3 0.07 3.47 0.36 5.00
152 INT179214 Binding of AMIGO2 4 0.32 3.9 0.35 5.00
153 INT449 Localization of PDAP1 4 0.66 2.29 0.33 5.00
154 INT230442 Binding of HAUS7 1 0.02 2.2 0.3 5.00
155 INT273611 Positive_regulation of Localization of Pah 1 0.40 0.75 0.24 5.00
156 INT273610 Positive_regulation of Positive_regulation of PVR 1 0.14 1.15 0.23 5.00
157 INT95576 Gene_expression of GUCY2C 4 0.42 1.78 0.21 5.00
158 INT273614 Regulation of PVR 1 0.17 0.84 0.14 5.00
159 INT273612 Negative_regulation of Gene_expression of Ptgir 1 0.05 0.65 0.13 5.00
160 INT230441 Positive_regulation of HRCT1 1 0.05 0.74 0.12 5.00
161 INT184790 Positive_regulation of Gene_expression of Ptgir 3 0.04 2.57 0.12 5.00
162 INT286904 Regulation of Binding of PDGFA 1 0.30 0.74 0.04 5.00
163 INT273620 Positive_regulation of Gene_expression of GUCY2C 1 0.01 1.48 0 5.00
164 INT273619 Negative_regulation of Gene_expression of GUCY2C 1 0.01 0.79 0 5.00
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