D:Seminoma

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Disease Term
Synonyms SEMINOMAS
Documents 148
Hot Single Events 82
Hot Interactions 2

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Seminoma. They are ordered first by their relevance to Seminoma and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT253935 Binding of PTPLA and Trpv1 1 0.14 1.25 0.65 93.44
2 INT196439 ALPPL2 Regulation of Localization of ALPP 1 0.21 0.65 0 93.04
3 INT192955 Binding of KIT and VCAM1 1 0.05 0.63 0 46.96
4 INT192956 Binding of CD2 and KIT 1 0.03 0.62 0 46.32
5 INT279145 Binding of VHL and RNF139 1 0.30 1.87 0 26.76
6 INT272418 CGA Regulation of Gene_expression of PROK1 1 0.01 0.34 0 25.68
7 INT279144 RNF139 Regulation of TSN 1 0.24 3.47 0 16.24
8 INT223828 Binding of GSTP1 and MAPK8 1 0.06 1.8 0.21 14.32
9 INT223827 MAPK8 Positive_regulation of Gene_expression of GSTP1 1 0.12 0.88 0.1 9.00
10 INT256629 Binding of Ptch1 and Shh 7 0.42 4.22 0.19 5.68
11 INT190702 CD40 Positive_regulation of Gene_expression of F3 1 0.00 1.4 0.55 5.00
12 INT339532 FGF2 Positive_regulation of YWHAZ 1 0.00 1.26 0.54 5.00
13 INT263917 Binding of SST and Sstr5 2 0.02 0.56 0.45 5.00
14 INT223829 Binding of GSTM1 and GSTP1 2 0.41 2.78 0.39 5.00
15 INT339570 Gene_expression of Positive_regulation of Gene_expression of CYP4A11 1 0.00 0.5 0.23 5.00
16 INT339535 FGF2 Positive_regulation of Gene_expression of CYP4A11 1 0.00 0.55 0.22 5.00
17 INT263901 Binding of Ighg1 and Slc3a2 1 0.00 0.89 0.16 5.00
18 INT244116 ELAVL3 Negative_regulation of MUC1 1 0.09 3.41 0.15 5.00
19 INT243468 Binding of SSTR1 and SSTR5 1 0.05 0.99 0.1 5.00
20 INT196444 Binding of ALPP and ALPPL2 1 0.17 0.59 0.1 5.00
21 INT339533 VEGFA Positive_regulation of Gene_expression of CYP2C8 1 0.09 0.57 0.09 5.00
22 INT243465 Binding of GH1 and GOPC 1 0.02 0.99 0.09 5.00
23 INT272439 Binding of ARAF and Prokr2 1 0.01 0.59 0.09 5.00
24 INT243466 POU1F1 Regulation of GH1 1 0.11 1.26 0.08 5.00
25 INT243464 POU1F1 Regulation of PRL 1 0.28 1.26 0.08 5.00
26 INT244640 AGK Negative_regulation of KIT 1 0.00 0.69 0.08 5.00
27 INT244639 AGK Negative_regulation of PDGFRB 1 0.01 0.69 0.08 5.00
28 INT339534 VEGFA Positive_regulation of CYP2C18 1 0.04 0.57 0.08 5.00
29 INT244638 AGK Negative_regulation of KDR 1 0.00 0.68 0.08 5.00
30 INT223825 GSTP1 Negative_regulation of MAPK8 1 0.11 1.53 0.06 5.00
31 INT244641 PDGFA Regulation of MTOR 1 0.07 2.55 0.06 5.00
32 INT272417 Binding of PROK1 and Positive_regulation of MAPK1 1 0.01 0.08 0.05 5.00
33 INT339569 VEGFA Positive_regulation of Litaf 1 0.18 0.6 0.04 5.00
34 INT223826 GSTM1 Negative_regulation of MAP3K5 1 0.02 0.71 0.03 5.00
35 INT223824 Binding of GSTM1 and MAP3K5 1 0.02 0.68 0.03 5.00
36 INT352840 Binding of Miox and Mirlet7a-1 1 0.00 0 0 5.00
37 INT263900 Binding of Col1a1 and Cea 1 0.01 0.63 0 5.00
38 INT241500 Binding of Kit and Kitl 1 0.08 0.92 0 5.00
39 INT242015 Binding of Mdm2 and Trp53 3 0.16 5.74 0 5.00
40 INT243467 PCSK1 Positive_regulation of POMC 1 0.08 1.62 0 5.00
41 INT279143 Binding of TSN and RNF139 1 0.31 0.83 0 5.00
42 INT263918 Binding of PTPRC and Cea 1 0.00 0.37 0 5.00
43 INT272416 PROK1 Positive_regulation of Gene_expression of VEGFA 1 0.26 0 0 5.00
44 INT196441 Binding of ALPP and PAEP 1 0.02 0 0 5.00
45 INT256632 Binding of PTCH1 and Jkamp 1 0.00 2.32 0 5.00
46 INT352841 Binding of Miox and Lin28a 1 0.00 0 0 5.00
47 INT352842 Binding of Lin28a and Mirlet7a-1 1 0.03 0 0 5.00
48 INT263899 Binding of PTPRC and TMED7-TICAM2 1 0.00 0.85 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Seminoma. They are ordered first by their pain relevance and then by number of times they were reported in Seminoma. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT339552 Positive_regulation of Gene_expression of EPHX2 1 0.16 5.37 0 99.84
2 INT156794 Gene_expression of CISH 41 0.58 23.09 5.03 99.64
3 INT27222 Gene_expression of ALPPL2 4 0.52 24.57 2.05 99.56
4 INT196469 Negative_regulation of Gene_expression of ALPPL2 1 0.28 3.43 0.1 99.56
5 INT34590 Gene_expression of ALPP 199 0.75 89.85 15.1 99.40
6 INT34594 Negative_regulation of Gene_expression of ALPP 12 0.50 5.04 1.41 99.40
7 INT339551 Gene_expression of EPHX2 1 0.18 8.11 0.03 99.28
8 INT192962 Positive_regulation of Transcription of KIT 1 0.46 2.74 0 99.24
9 INT108799 Regulation of Gene_expression of ALPP 9 0.27 2.98 0.62 99.12
10 INT196473 Regulation of Gene_expression of ALPPL2 1 0.30 1.96 0 99.12
11 INT69264 Gene_expression of KIT 207 0.78 179.41 8.95 99.04
12 INT134811 Gene_expression of ICA1 22 0.44 6.47 2.42 99.04
13 INT196471 Negative_regulation of Gene_expression of ICA1 2 0.10 1.51 0.32 99.04
14 INT192957 Transcription of KIT 5 0.69 2.19 0.23 99.04
15 INT2614 Gene_expression of CGA 187 0.78 105.89 24.77 98.88
16 INT119102 Gene_expression of PDGFRA 13 0.75 11.99 0.81 98.88
17 INT124185 Negative_regulation of Kit 57 0.59 35.43 3.61 98.74
18 INT160392 Negative_regulation of Tnfrsf8 2 0.08 3.06 0.12 98.74
19 INT8145 Localization of CGB5 13 0.74 3.68 6.47 98.72
20 INT104220 Positive_regulation of Gene_expression of PPIG 14 0.49 7.38 1.7 98.64
21 INT91891 Gene_expression of Kit 268 0.78 158.89 22.67 97.76
22 INT151450 Positive_regulation of Gene_expression of Kit 23 0.69 13.11 1.43 97.76
23 INT154527 Gene_expression of POU5F1 180 0.78 34.01 4.34 97.44
24 INT90021 Gene_expression of IGKV2D-40 6 0.13 3.07 1.31 97.44
25 INT69029 Gene_expression of PTPRC 127 0.75 74.26 11.57 97.44
26 INT6510 Gene_expression of AFP 130 0.78 119.2 9.19 97.00
27 INT1792 Positive_regulation of CGA 123 0.70 64.73 20.79 96.92
28 INT196464 Localization of ALPPL2 1 0.50 2.22 0.09 96.72
29 INT4342 Localization of ALPP 27 0.69 15.19 5.32 96.72
30 INT272430 Localization of PROK1 4 0.66 2.01 0.14 96.12
31 INT54438 Binding of ALPP 25 0.39 14.02 0.96 96.04
32 INT196461 Binding of ALPPL2 1 0.32 4.1 0.2 95.84
33 INT70877 Gene_expression of PPIG 72 0.75 22.39 10.93 95.84
34 INT246978 Binding of PTPLA 3 0.18 3.62 2.79 94.80
35 INT188166 Transcription of ALPP 9 0.56 4.34 0.62 94.20
36 INT6511 Positive_regulation of AFP 76 0.70 70.15 7.28 94.12
37 INT8571 Gene_expression of B3GAT1 54 0.75 36.85 15.98 93.52
38 INT4830 Binding of Trpv1 158 0.48 45.11 84.2 93.44
39 INT4953 Positive_regulation of CGB5 16 0.60 7.63 2.49 92.96
40 INT129783 Positive_regulation of Gene_expression of KIT 16 0.50 18.12 0.58 92.60
41 INT88278 Binding of Kit 33 0.37 24.45 4.13 92.56
42 INT142184 Regulation of TXK 10 0.11 8.25 0.59 91.68
43 INT10094 Negative_regulation of ALPP 36 0.37 20.45 6.45 90.92
44 INT108800 Negative_regulation of ALPPL2 2 0.28 1.83 0.99 90.92
45 INT91890 Positive_regulation of Kit 36 0.50 25.44 3.06 90.68
46 INT196470 Regulation of ALPPL2 1 0.30 2.21 0 89.28
47 INT16235 Positive_regulation of CGB 27 0.70 15.71 4.06 88.96
48 INT125592 Negative_regulation of Negative_regulation of CDKN1A 2 0.42 2.07 0.41 88.80
49 INT104330 Negative_regulation of CDKN1A 57 0.58 39.93 5.88 88.80
50 INT323284 Negative_regulation of EPHX2 4 0.14 8.25 0.54 88.44
51 INT160606 Localization of AFP 6 0.74 3.39 1.29 88.40
52 INT281250 Negative_regulation of Negative_regulation of CDKN2D 1 0.08 1.49 0 88.16
53 INT251628 Negative_regulation of CDKN2D 2 0.15 1.83 0 88.16
54 INT272438 Gene_expression of PROK1 32 0.63 15.06 1.01 88.16
55 INT200107 Gene_expression of SDHA 9 0.37 5.29 1.02 88.00
56 INT23104 Positive_regulation of Cga 20 0.70 10.35 8.03 87.84
57 INT281253 Negative_regulation of Negative_regulation of LAMTOR1 1 0.09 1.49 0 87.76
58 INT281251 Negative_regulation of LAMTOR1 1 0.12 1.42 0 87.76
59 INT190696 Gene_expression of Prame 1 0.75 2.4 0.03 87.76
60 INT64797 Regulation of ALPP 18 0.24 9.71 2.24 87.60
61 INT281254 Negative_regulation of Negative_regulation of CDKN2A 1 0.08 1.44 0 87.36
62 INT92141 Negative_regulation of CDKN2A 53 0.57 44.23 2.48 87.36
63 INT58061 Gene_expression of Trpv1 1117 0.78 451.54 637.59 85.84
64 INT39357 Binding of Afp 5 0.48 3.58 0.85 85.64
65 INT51066 Binding of S100B 24 0.48 13.5 0.97 85.64
66 INT160391 Binding of Tnfrsf8 2 0.07 2.52 0.07 85.64
67 INT62331 Gene_expression of TNFRSF8 26 0.72 17.75 2.08 84.64
68 INT3913 Positive_regulation of ABAT 47 0.69 22.73 33.4 84.60
69 INT17739 Gene_expression of S100B 226 0.78 132.7 26.4 84.16
70 INT4988 Gene_expression of KRT1 64 0.77 43.4 4.12 83.44
71 INT247431 Positive_regulation of Negative_regulation of RB1 2 0.45 2.58 0 83.36
72 INT94165 Negative_regulation of RB1 30 0.52 27.29 0.51 83.36
73 INT76531 Transcription of Trpv1 62 0.72 23.69 34.77 82.52
74 INT8669 Positive_regulation of Afp 66 0.70 58.21 7.67 81.96
75 INT52937 Gene_expression of Cd68 37 0.67 31.33 7.54 81.64
76 INT117662 Gene_expression of ABL1 21 0.69 18.76 0.39 81.52
77 INT80421 Positive_regulation of IFI27 26 0.65 15.32 3.93 81.28
78 INT11203 Gene_expression of BCR 30 0.75 33.49 1.22 81.20
79 INT161794 Negative_regulation of Gene_expression of Cd68 4 0.27 3.97 1.59 81.08
80 INT272437 Positive_regulation of Transcription of PROK2 1 0.30 1.67 0 81.08
81 INT281256 Positive_regulation of CCND2 1 0.20 1.42 0 80.64
82 INT272435 Transcription of PROK2 1 0.34 1.66 0 80.48
83 INT9908 Negative_regulation of IAPP 29 0.57 19.37 2.12 77.76
84 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 75.00
85 INT5398 Positive_regulation of ALPP 178 0.70 110.52 19.18 75.00
86 INT172678 Gene_expression of NUPL2 20 0.75 5.06 2.85 74.92
87 INT200109 Positive_regulation of Gene_expression of NUPL2 1 0.49 0.44 0.1 74.92
88 INT192960 Regulation of Gene_expression of KIT 3 0.45 4.16 0 74.88
89 INT83531 Gene_expression of KITLG 54 0.65 26 7.07 74.28
90 INT272427 Regulation of Gene_expression of ARAF 2 0.02 1.33 0.12 72.80
91 INT268379 Gene_expression of ARAF 22 0.16 9.34 1.07 71.60
92 INT216123 Negative_regulation of Cd68 2 0.41 1.96 1.48 69.80
93 INT196472 Transcription of ALPPL2 1 0.46 0.95 0.07 68.48
94 INT272436 Negative_regulation of Gene_expression of PROK1 3 0.40 2.3 0.17 67.76
95 INT182465 Negative_regulation of Cd1d1 4 0.28 1.72 0.29 67.72
96 INT60126 Regulation of Trpv1 186 0.62 85.53 133.4 67.12
97 INT155036 Localization of NT5E 6 0.73 4.1 1.35 64.52
98 INT148207 Gene_expression of CTLA4 53 0.77 29.13 12.07 63.76
99 INT90094 Gene_expression of Cytl1 14 0.75 12.75 2.81 63.76
100 INT165066 Gene_expression of GAGE4 3 0.09 2.82 0.57 63.76
101 INT85085 Positive_regulation of KIT 36 0.53 30.08 2.17 61.60
102 INT120761 Positive_regulation of GSTP1 3 0.50 3.4 0.19 61.28
103 INT136180 Binding of MTOR 9 0.35 5.01 0.38 60.16
104 INT955 Gene_expression of GHRH 126 0.78 59.91 20.74 58.96
105 INT64201 Negative_regulation of Trpv1 203 0.59 79.18 119.75 57.52
106 INT64202 Positive_regulation of Trpv1 643 0.70 249.66 397.42 55.76
107 INT136182 Negative_regulation of PDGFRA 3 0.43 2.43 0.08 55.68
108 INT249 Localization of GHRH 215 0.80 78.02 51.87 55.60
109 INT110550 Regulation of CYP2C8 3 0.45 1.59 1.34 54.84
110 INT252 Localization of GH1 529 0.80 227.4 122.05 54.56
111 INT68372 Regulation of CYP2C9 28 0.62 5.64 9.53 54.40
112 INT95116 Negative_regulation of PDGFA 24 0.57 19.56 1.29 54.24
113 INT279147 Negative_regulation of RNF139 1 0.53 5.41 0.06 54.00
114 INT109327 Negative_regulation of KIT 42 0.57 43.2 2.15 51.04
115 INT123877 Negative_regulation of ABL1 40 0.57 27.94 1.17 50.64
116 INT1921 Gene_expression of CEACAM7 47 0.78 43.23 2.53 50.00
117 INT200108 Binding of CGB 2 0.11 1.22 0 50.00
118 INT136181 Negative_regulation of BCR 5 0.42 2.94 0 49.92
119 INT62002 Regulation of Cd68 6 0.35 7.89 0.86 49.20
120 INT101068 Negative_regulation of CDCP1 27 0.03 17.67 3.45 48.72
121 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 47.40
122 INT352832 Regulation of Miox 1 0.00 0.51 0.05 45.92
123 INT66061 Positive_regulation of Gene_expression of AFP 6 0.70 8.67 0.81 45.04
124 INT76735 Positive_regulation of CGB7 3 0.38 2.91 0.28 45.04
125 INT150123 Positive_regulation of Gene_expression of CGB7 2 0.40 1.64 0.19 45.04
126 INT196475 Positive_regulation of Gene_expression of ALPPL2 1 0.33 2.3 0.03 39.84
127 INT32107 Gene_expression of PTPLA 14 0.47 8.06 6.76 39.76
128 INT76732 Gene_expression of CGB7 4 0.63 4.14 0.37 39.28
129 INT34592 Positive_regulation of Gene_expression of ALPP 51 0.67 20.62 5.68 39.04
130 INT109208 Gene_expression of Miox 3 0.15 1.19 1.16 38.72
131 INT44378 Gene_expression of GSTM1 69 0.76 34.61 8.81 37.64
132 INT467 Gene_expression of POMC 1048 0.78 332.8 394.16 37.36
133 INT205973 Binding of SHH 3 0.35 1.03 0.07 37.20
134 INT128376 Binding of KIT 26 0.48 14.24 0.47 36.76
135 INT213515 Binding of Shh 8 0.37 1.92 0.08 36.56
136 INT1579 Gene_expression of PRL 279 0.78 119.2 55.41 35.92
137 INT142416 Binding of Ptch1 6 0.34 4.92 0.74 34.48
138 INT272432 Regulation of PROK1 2 0.42 1.16 0.18 33.20
139 INT272426 Regulation of Regulation of PROK1 1 0.21 0.33 0 33.20
140 INT200219 Positive_regulation of VHL 18 0.50 15.38 0.67 33.00
141 INT218956 Regulation of RNF123 3 0.01 1.06 0.03 31.60
142 INT186998 Negative_regulation of Gene_expression of KIT 20 0.43 16.77 0.46 31.44
143 INT71602 Negative_regulation of Trp53 84 0.59 67.77 3.68 30.68
144 INT71789 Positive_regulation of MAPK1 396 0.70 234.44 89.27 27.00
145 INT188047 Positive_regulation of Wnt2 51 0.58 31.41 2.94 27.00
146 INT272433 Regulation of Gene_expression of PROK1 1 0.49 0.7 0 25.68
147 INT135299 Binding of PTCH1 10 0.48 12.16 0.84 22.32
148 INT279159 Regulation of RNF139 1 0.56 2.98 0 22.04
149 INT89054 Positive_regulation of Gene_expression of Trpv1 156 0.70 90.78 102.03 17.32
150 INT324396 Negative_regulation of Miox 1 0.05 0 0 17.04
151 INT140037 Positive_regulation of Positive_regulation of Notch1 2 0.22 1.34 0.69 15.28
152 INT279151 Regulation of TSN 1 0.37 3.34 0 15.04
153 INT208561 Gene_expression of Shh 51 0.78 9.57 1.77 14.56
154 INT232799 Regulation of Gene_expression of Shh 3 0.27 1.04 0.16 14.56
155 INT135077 Binding of GSTP1 11 0.48 7.03 1.8 14.32
156 INT123726 Positive_regulation of Notch1 23 0.70 7.2 5.65 14.04
157 INT116950 Negative_regulation of MAPK8 103 0.57 44.48 17.53 13.12
158 INT80690 Positive_regulation of MAPK8 223 0.68 125.63 36.75 12.24
159 INT279152 Positive_regulation of RNF139 1 0.46 1.29 0 10.88
160 INT109908 Localization of MAPK8 10 0.73 3.86 2.14 9.80
161 INT223834 Localization of GSTP1 2 0.70 1.28 0.1 9.80
162 INT87406 Gene_expression of GSTP1 16 0.77 11.37 0.35 7.68
163 INT116842 Negative_regulation of CYP2J2 4 0.39 3.31 0 7.60
164 INT272419 Regulation of Prokr1 1 0.08 0.29 0 6.16
165 INT443 Localization of POMC 1020 0.81 284.52 443.17 5.00
166 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
167 INT720 Positive_regulation of POMC 807 0.70 237.37 353.83 5.00
168 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
169 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 5.00
170 INT22548 Positive_regulation of Casp3 483 0.70 258.78 213.07 5.00
171 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 5.00
172 INT425 Localization of PRL 455 0.81 189.64 144.8 5.00
173 INT65600 Positive_regulation of Casp3 376 0.70 198.44 128.03 5.00
174 INT14151 Gene_expression of Casp3 311 0.78 140.26 120.68 5.00
175 INT50674 Gene_expression of PTGS2 459 0.78 253.33 118.51 5.00
176 INT12339 Localization of IL8 437 0.81 251.87 117.39 5.00
177 INT27096 Positive_regulation of Nfkb1 325 0.70 195.11 109.06 5.00
178 INT12082 Localization of IL6 365 0.81 241.78 105.78 5.00
179 INT915 Positive_regulation of PRL 342 0.70 141.96 104.31 5.00
180 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83 5.00
181 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
182 INT10838 Positive_regulation of IL8 381 0.70 295.51 101.62 5.00
183 INT38731 Localization of Trpv1 138 0.81 52.73 90.49 5.00
184 INT914 Positive_regulation of GH1 292 0.69 100.7 84.91 5.00
185 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 5.00
186 INT920 Localization of PLOD1 223 0.81 42.25 78.7 5.00
187 INT56298 Gene_expression of IL4 306 0.78 182.18 72.92 5.00
188 INT10837 Positive_regulation of Gene_expression of IL8 294 0.70 190.08 70.34 5.00
189 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 5.00
190 INT8347 Gene_expression of SST 181 0.78 104.59 65.45 5.00
191 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64 5.00
192 INT103924 Positive_regulation of Akt1 359 0.69 158.94 60.34 5.00
193 INT69876 Negative_regulation of Nfkb1 147 0.58 89.81 55.5 5.00
194 INT7093 Negative_regulation of CYP2B6 146 0.58 37.3 48.39 5.00
195 INT106525 Phosphorylation of Akt1 436 0.82 183.81 47.82 5.00
196 INT531 Gene_expression of GH1 376 0.75 193.45 46.24 5.00
197 INT1726 Positive_regulation of Kitl 65 0.70 38.81 44.85 5.00
198 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53 5.00
199 INT73502 Positive_regulation of IL10 154 0.69 124.87 43.5 5.00
200 INT5130 Regulation of GNRH1 139 0.62 31.95 42.08 5.00
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