D:Serositis

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Disease Term
Synonyms SEROSITIDES
Documents 114
Hot Single Events 33
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Serositis. They are ordered first by their relevance to Serositis and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT231796 Binding of Fcr and Sle1 1 0.01 1.62 0.33 60.48
2 INT220905 Cfb Positive_regulation of C3 1 0.06 0.91 0.11 58.80
3 INT277765 Binding of BCR and Abl1 1 0.18 1.55 0.03 50.12
4 INT115367 Binding of IL6 and IL6R 12 0.07 8.16 2.36 26.76
5 INT352970 IL4 Negative_regulation of Positive_regulation of TH1L 1 0.01 0.91 0.4 24.44
6 INT352972 IL4 Negative_regulation of Gene_expression of IL8 1 0.07 1.01 0.43 19.08
7 INT352985 IL4 Negative_regulation of Gene_expression of Il6 1 0.01 1 0.43 19.08
8 INT151849 IL10 Negative_regulation of Gene_expression of IL8 4 0.14 3.26 1.54 18.72
9 INT352986 IL10 Negative_regulation of Gene_expression of Il6 1 0.01 1 0.43 18.72
10 INT102130 Il6 Positive_regulation of Gene_expression of Crp 4 0.05 7.39 1.91 5.00
11 INT194644 Tlr4 Positive_regulation of TNF 6 0.58 2.42 0.76 5.00
12 INT320152 IL6 Positive_regulation of IL1RN 2 0.23 2.59 0.66 5.00
13 INT194641 Binding of IL10 and TNF 2 0.14 1.09 0.35 5.00
14 INT231797 Glrb Regulation of Negative_regulation of TNF 1 0.02 1.49 0.25 5.00
15 INT320153 Negative_regulation of Binding of IL6 and IL6R 1 0.02 0.37 0.24 5.00
16 INT220903 Regulation of Binding of Crp and Cd40 1 0.05 0.37 0.05 5.00
17 INT220906 Binding of Crp and Cd40 1 0.04 0.37 0.05 5.00
18 INT188432 Negative_regulation of Binding of ABCA1 and IL6 1 0.02 0.47 0.05 5.00
19 INT188431 Binding of ABCA1 and IL6 1 0.02 0.47 0.05 5.00
20 INT194642 IL10 Positive_regulation of TNF 1 0.18 0.22 0.04 5.00
21 INT220901 Regulation of Binding of Saa1 and Cd40 1 0.04 0.36 0 5.00
22 INT220902 Binding of C4b and C4bp 1 0.45 1.02 0 5.00
23 INT194645 Negative_regulation of Tlr4 Positive_regulation of TNF 1 0.01 0.27 0 5.00
24 INT220907 Binding of C4bp and Cfb 1 0.08 0.52 0 5.00
25 INT220900 Binding of C4bp and Cd40 1 0.21 0.72 0 5.00
26 INT306764 Binding of Aes and ZMYND10 1 0.04 0.21 0 5.00
27 INT220908 Binding of Saa1 and Cd40 1 0.04 0.36 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Serositis. They are ordered first by their pain relevance and then by number of times they were reported in Serositis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT69985 Positive_regulation of Negative_regulation of TNF 21 0.50 13.26 6.31 100.00
2 INT45975 Positive_regulation of SAA1 17 0.67 19.7 4.15 100.00
3 INT69981 Positive_regulation of Negative_regulation of Il1rn 2 0.09 3.28 2.48 100.00
4 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 99.68
5 INT69980 Negative_regulation of Il1rn 11 0.33 7.75 6.7 99.68
6 INT1901 Binding of Mefv 24 0.48 32.26 4.5 99.20
7 INT97513 Localization of Mefv 6 0.71 8.14 1.55 98.92
8 INT174653 Localization of MEFV 15 0.70 12.06 1.93 96.84
9 INT8243 Positive_regulation of Il6 451 0.70 358.24 119.28 95.88
10 INT37390 Regulation of Crp 39 0.46 28.74 11.45 95.00
11 INT150395 Binding of MEFV 55 0.44 31.18 3.42 92.96
12 INT159248 Positive_regulation of Binding of MEFV 2 0.46 2.54 0.2 92.96
13 INT6481 Binding of TNF 624 0.48 510.2 214.82 92.76
14 INT17417 Positive_regulation of Ighd 16 0.69 24.29 2.8 91.60
15 INT57545 Positive_regulation of Positive_regulation of Ighd 1 0.15 1.78 0.24 91.60
16 INT8413 Gene_expression of Ptgs1 248 0.78 110.17 108.58 90.40
17 INT45840 Positive_regulation of Gene_expression of Ptgs1 35 0.50 16.07 20.49 90.40
18 INT167056 Gene_expression of CALR 29 0.75 20.05 1.25 90.36
19 INT204019 Negative_regulation of C2 10 0.26 6.23 2.44 90.24
20 INT3987 Positive_regulation of IGHE 316 0.70 283.2 40.16 90.20
21 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 90.20
22 INT23147 Negative_regulation of MRI1 26 0.38 14.33 8.96 89.28
23 INT50058 Negative_regulation of Cpox 907 0.58 426.28 428.29 88.72
24 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 88.16
25 INT9082 Positive_regulation of ESR1 238 0.69 148.51 36.69 88.08
26 INT67374 Gene_expression of Mefv 15 0.74 49.1 8.07 87.52
27 INT3361 Positive_regulation of Esr1 273 0.69 208.53 44.81 84.08
28 INT156975 Gene_expression of SLEB1 31 0.65 38.83 6.73 83.12
29 INT23246 Gene_expression of HLA-DRB4 37 0.64 36.79 6.61 82.84
30 INT144020 Positive_regulation of Pdgfrb 30 0.69 24.8 1.92 82.72
31 INT13354 Transcription of TNF 108 0.72 85.81 42.32 82.60
32 INT13520 Binding of HLA-DRB4 30 0.42 32.65 6.74 80.92
33 INT88053 Gene_expression of IGHD@ 2 0.61 4.41 0.17 80.76
34 INT103638 Negative_regulation of MEFV 7 0.39 5.88 0.54 77.64
35 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 77.36
36 INT60526 Gene_expression of IL10 449 0.78 292.71 107.84 76.72
37 INT184365 Negative_regulation of C3 19 0.43 13.86 2.89 74.96
38 INT184341 Negative_regulation of C4b 12 0.50 7.66 0.75 74.96
39 INT111205 Positive_regulation of Mefv 3 0.43 4.07 0.66 74.08
40 INT86411 Negative_regulation of Negative_regulation of TNF 24 0.42 17.6 7.89 72.00
41 INT63349 Gene_expression of PECAM1 199 0.75 166.03 36.76 71.96
42 INT24876 Gene_expression of CD34 172 0.78 91.02 12.39 71.96
43 INT152681 Gene_expression of PDPN 29 0.65 23.06 0.18 71.96
44 INT72651 Gene_expression of TH1L 114 0.75 80.15 35.15 69.60
45 INT347444 Gene_expression of KRTAP5-2 1 0.16 1.4 0.09 69.04
46 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 68.88
47 INT90406 Gene_expression of IL6R 27 0.38 15.74 3.64 68.88
48 INT162478 Gene_expression of KRT6B 2 0.75 1.39 0.08 68.36
49 INT181973 Positive_regulation of MAS1 8 0.49 7.64 1.07 66.36
50 INT4960 Positive_regulation of CSF2 285 0.70 256.73 65.73 65.36
51 INT89404 Regulation of Negative_regulation of TNF 30 0.45 24.47 12.71 64.84
52 INT67373 Regulation of Gene_expression of Mefv 2 0.39 6.28 0.75 64.32
53 INT179542 Positive_regulation of C3 27 0.52 19.39 3.83 60.44
54 INT22112 Positive_regulation of Localization of TNF 164 0.70 115.66 52.18 60.00
55 INT6852 Localization of TNF 883 0.81 705.95 270.84 59.00
56 INT181015 Gene_expression of C3ar1 12 0.58 8.9 2.18 57.64
57 INT220894 Positive_regulation of C3ar1 4 0.09 3.75 0.41 57.64
58 INT220897 Gene_expression of Cfi 1 0.01 0.91 0.11 57.64
59 INT231794 Binding of Fcr 4 0.07 3.08 1.07 57.40
60 INT131488 Binding of MAS1 9 0.36 8.49 1.01 54.36
61 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 54.04
62 INT8483 Positive_regulation of Positive_regulation of TNF 73 0.67 60.35 22.03 52.40
63 INT22882 Negative_regulation of IMPA1 10 0.57 5.19 0.31 51.84
64 INT9660 Regulation of TNF 363 0.62 312.94 139.99 47.04
65 INT73497 Regulation of IL10 33 0.45 22.6 9.19 46.40
66 INT142162 Binding of IL10 30 0.37 21.9 4.84 46.40
67 INT199563 Negative_regulation of Abl1 38 0.46 21.5 0.87 45.04
68 INT6596 Positive_regulation of HLA-DRB1 33 0.61 27.01 7.26 41.72
69 INT162057 Negative_regulation of TNFSF11 14 0.58 9.78 1.46 41.64
70 INT19775 Localization of Il1 183 0.78 145.5 50.91 41.52
71 INT183967 Positive_regulation of Btg3 9 0.58 9.04 1.03 39.36
72 INT46389 Positive_regulation of Cfb 20 0.23 8.29 1.49 37.60
73 INT223080 Binding of Pdgfa 8 0.18 7.21 2.44 36.92
74 INT352983 Protein_catabolism of IL10 1 0.13 1.04 0.41 35.64
75 INT236270 Binding of Hhex 2 0.07 1.55 0.29 35.60
76 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 35.20
77 INT55698 Regulation of Binding of TNF 13 0.44 8.98 4.74 34.44
78 INT218463 Negative_regulation of Binding of Cfb 7 0.08 2.31 0.28 34.00
79 INT220895 Negative_regulation of Binding of C3 3 0.28 0.95 0.16 34.00
80 INT220889 Negative_regulation of Binding of C4b 1 0.36 0.53 0.07 34.00
81 INT155160 Binding of C3 20 0.47 7.77 2.61 33.40
82 INT184378 Binding of Cfb 54 0.20 12.49 2.36 33.40
83 INT172104 Binding of C4b 4 0.41 3.89 0.13 32.04
84 INT320154 Phosphorylation of IL6R 1 0.04 1.13 0.21 28.24
85 INT86437 Binding of IL6 154 0.48 121.22 29.3 26.76
86 INT174816 Binding of IL6R 14 0.09 11.26 3.63 26.76
87 INT17564 Gene_expression of Gpt 322 0.75 208.51 60.36 23.76
88 INT20622 Gene_expression of LDHA 107 0.76 77.97 16.3 23.76
89 INT80657 Gene_expression of SLC17A5 50 0.75 39.98 5.44 23.76
90 INT80656 Regulation of SLC17A5 15 0.26 6.89 3.19 23.76
91 INT75540 Positive_regulation of TH1L 62 0.67 43.45 15.02 23.72
92 INT11380 Negative_regulation of IL1B 215 0.59 125.62 72.35 23.24
93 INT68702 Negative_regulation of C4bp 6 0.57 7.44 0.5 22.80
94 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61 22.16
95 INT183966 Localization of Btg3 2 0.63 2.94 0.45 21.04
96 INT135722 Positive_regulation of Gene_expression of ANGPTL5 5 0.39 4.52 1.05 18.96
97 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 17.92
98 INT8548 Gene_expression of HP 86 0.77 47.62 11.94 17.92
99 INT9951 Gene_expression of ANGPTL5 45 0.53 37.2 6.44 17.92
100 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 17.48
101 INT60527 Transcription of IL10 16 0.56 13.57 6.42 14.56
102 INT56299 Transcription of IL4 15 0.64 10.2 5.44 14.56
103 INT220893 Gene_expression of C4bp 1 0.74 3.37 0.29 12.04
104 INT11685 Regulation of CSF2 99 0.59 58.82 15.9 6.44
105 INT16260 Gene_expression of Bdnf 671 0.78 283.44 339.1 5.00
106 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 5.00
107 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 5.00
108 INT16259 Positive_regulation of Bdnf 336 0.70 183.48 209.82 5.00
109 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 5.00
110 INT19472 Gene_expression of Il1 554 0.76 419.75 175.35 5.00
111 INT15516 Gene_expression of Crp 711 0.77 615.33 173.09 5.00
112 INT867 Gene_expression of IFNA1 930 0.78 594.85 168.03 5.00
113 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 5.00
114 INT7533 Gene_expression of Tlr4 720 0.78 343.22 121.57 5.00
115 INT118381 Gene_expression of Il17a 405 0.76 306.97 112.06 5.00
116 INT11051 Positive_regulation of Gene_expression of IL6 415 0.69 319.21 109.3 5.00
117 INT12082 Localization of IL6 365 0.81 241.78 105.78 5.00
118 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
119 INT10838 Positive_regulation of IL8 381 0.70 295.51 101.62 5.00
120 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 5.00
121 INT82448 Gene_expression of S100a8 246 0.77 236.72 84.02 5.00
122 INT749 Gene_expression of HLA-B 341 0.75 224.12 77.37 5.00
123 INT9236 Regulation of Gene_expression of TNF 204 0.62 162.66 72.99 5.00
124 INT10837 Positive_regulation of Gene_expression of IL8 294 0.70 190.08 70.34 5.00
125 INT6849 Localization of IL1B 229 0.81 112.56 69.63 5.00
126 INT7534 Gene_expression of Ifng 193 0.78 111.02 68.6 5.00
127 INT9657 Positive_regulation of Gene_expression of Il6 237 0.70 180.45 63.6 5.00
128 INT11318 Gene_expression of Gtf3a 274 0.52 183.82 60.89 5.00
129 INT5058 Positive_regulation of IFNA1 356 0.70 245.75 60.52 5.00
130 INT1759 Gene_expression of TIMP1 267 0.77 133.87 59.29 5.00
131 INT48901 Negative_regulation of IL6 186 0.57 136.33 57.87 5.00
132 INT73048 Gene_expression of MMP9 268 0.77 159.75 57.81 5.00
133 INT78899 Gene_expression of CCL5 155 0.77 84.02 55.09 5.00
134 INT20382 Gene_expression of Hand2 211 0.66 142.26 51.05 5.00
135 INT9210 Regulation of IL6 166 0.62 125.61 49.95 5.00
136 INT18522 Positive_regulation of Gene_expression of IFNA1 248 0.67 160.85 44.87 5.00
137 INT73502 Positive_regulation of IL10 154 0.69 124.87 43.5 5.00
138 INT13556 Gene_expression of CD4 367 0.78 230.82 41.74 5.00
139 INT97596 Localization of S100a8 94 0.78 90.69 40.41 5.00
140 INT52732 Negative_regulation of CRP 169 0.59 138.47 40.33 5.00
141 INT92517 Gene_expression of Grin1 105 0.78 29.53 39.43 5.00
142 INT12892 Negative_regulation of TIMP1 136 0.58 83.13 36.54 5.00
143 INT9239 Regulation of Gene_expression of IL6 106 0.61 75.24 36.53 5.00
144 INT53577 Negative_regulation of Localization of TNF 110 0.59 59.28 35.23 5.00
145 INT47710 Negative_regulation of GRIN1 71 0.57 25.57 34.24 5.00
146 INT81289 Positive_regulation of Gene_expression of Tlr4 192 0.69 104.5 33.89 5.00
147 INT6302 Binding of IFNA1 196 0.48 133.85 32.73 5.00
148 INT99610 Localization of MMP9 126 0.79 48.46 32.67 5.00
149 INT62830 Gene_expression of VCAM1 149 0.78 125.23 32.4 5.00
150 INT11554 Negative_regulation of CSF2 129 0.59 108.55 29.44 5.00
151 INT37296 Binding of Esr1 117 0.43 62.51 27.33 5.00
152 INT14690 Localization of CSF2 124 0.80 85.17 27.26 5.00
153 INT3760 Positive_regulation of ALB 142 0.70 87.46 26.7 5.00
154 INT16428 Positive_regulation of Gtf3a 135 0.20 106.44 26.67 5.00
155 INT73047 Positive_regulation of MMP9 133 0.68 73.22 26.42 5.00
156 INT17739 Gene_expression of S100B 226 0.78 132.7 26.4 5.00
157 INT69036 Gene_expression of IL18 99 0.77 77.92 25.95 5.00
158 INT70048 Positive_regulation of Gene_expression of IL10 90 0.55 71.34 25.66 5.00
159 INT122570 Negative_regulation of Akt1 173 0.59 91.44 25.53 5.00
160 INT55583 Localization of IFNA1 135 0.78 85.07 24.13 5.00
161 INT74423 Localization of IL10 91 0.80 61.6 22.95 5.00
162 INT49196 Gene_expression of SELE 105 0.78 107.29 22.92 5.00
163 INT19330 Binding of HLA-A 99 0.48 76.26 22.85 5.00
164 INT23257 Regulation of CRP 127 0.62 100.05 21.87 5.00
165 INT150022 Positive_regulation of Il17a 69 0.64 70.04 21.87 5.00
166 INT14700 Regulation of IFNA1 111 0.45 66.16 21.52 5.00
167 INT5328 Positive_regulation of CD4 191 0.69 133.43 21.31 5.00
168 INT78901 Localization of CCL5 67 0.78 40.79 20.59 5.00
169 INT86751 Negative_regulation of Il10 62 0.59 40.1 20.51 5.00
170 INT14701 Negative_regulation of IFNA1 118 0.54 84.19 20.08 5.00
171 INT51055 Positive_regulation of TIMP1 103 0.69 50.07 19.86 5.00
172 INT18311 Positive_regulation of CD8A 145 0.69 113.48 19.44 5.00
173 INT756 Gene_expression of C3 138 0.75 100.6 19.2 5.00
174 INT5398 Positive_regulation of ALPP 178 0.70 110.52 19.18 5.00
175 INT78024 Gene_expression of ACLY 73 0.75 59.15 18.54 5.00
176 INT112017 Regulation of Hand2 77 0.36 62.23 18.04 5.00
177 INT2216 Gene_expression of SELL 92 0.77 59.29 17.71 5.00
178 INT34057 Negative_regulation of Gene_expression of IFNA1 65 0.58 43.46 17.25 5.00
179 INT19929 Negative_regulation of Positive_regulation of TNF 52 0.59 38.16 16.51 5.00
180 INT1020 Negative_regulation of BCHE 109 0.59 44.86 16.4 5.00
181 INT10721 Gene_expression of BDNF-AS 119 0.76 72.8 16.29 5.00
182 INT899 Gene_expression of F13A1 122 0.70 78.02 16.26 5.00
183 INT9220 Gene_expression of Ighg1 125 0.77 85.74 15.92 5.00
184 INT170855 Negative_regulation of GOPC 188 0.38 70.92 15.41 5.00
185 INT81627 Gene_expression of Fas 120 0.78 115.51 15.36 5.00
186 INT12087 Regulation of Localization of TNF 44 0.62 28.71 15.17 5.00
187 INT19963 Gene_expression of COL1A1 118 0.59 42.11 15.15 5.00
188 INT18513 Binding of GRIN1 32 0.47 9.44 15.08 5.00
189 INT10709 Negative_regulation of CD4 106 0.59 95.6 14.89 5.00
190 INT133156 Binding of Cd40 77 0.48 45.92 13.77 5.00
191 INT56651 Binding of HLA-DRB1 58 0.48 52.25 13.68 5.00
192 INT5207 Negative_regulation of Alms1 70 0.41 41.56 13.68 5.00
193 INT6478 Negative_regulation of Binding of TNF 36 0.58 30.42 13.31 5.00
194 INT87235 Negative_regulation of Il4 54 0.48 31.51 13.15 5.00
195 INT10016 Negative_regulation of CD8A 81 0.42 56.68 13.15 5.00
196 INT7532 Negative_regulation of Gene_expression of Ifng 33 0.59 18.56 13.14 5.00
197 INT81629 Positive_regulation of Fas 58 0.70 59.63 12.94 5.00
198 INT35801 Regulation of Alms1 34 0.38 20.88 12.38 5.00
199 INT55687 Localization of TIMP1 47 0.74 30.24 12.31 5.00
200 INT4047 Binding of F13A1 105 0.43 66.54 11.81 5.00
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