D:Serotonin Syndrome

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Disease Term
Synonyms SEROTONERGIC SYNDROME, Serotonin Disorder, Serotonin Syndromes, Syndrome Serotonin, Syndromes Serotonin
Documents 206
Hot Single Events 24
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Serotonin Syndrome. They are ordered first by their relevance to Serotonin Syndrome and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT264568 Binding of STS and CYP1A2 1 0.20 0.18 0.06 29.84
2 INT235604 Binding of Htr1a and Htr3a 1 0.01 0 0.74 5.00
3 INT261517 Binding of HTR2A and USH1C 1 0.01 0 0.66 5.00
4 INT330984 Negative_regulation of CYP2D6 Positive_regulation of Localization of CYP1A2 1 0.46 0 0.62 5.00
5 INT286708 Negative_regulation of Mapk1 Negative_regulation of Casp3 1 0.12 0 0.31 5.00
6 INT286702 Positive_regulation of Mapk1 Positive_regulation of Positive_regulation of Rps6ka5 1 0.37 0.18 0.29 5.00
7 INT286705 Positive_regulation of Mapk1 Positive_regulation of Phosphorylation of Rps6ka5 1 0.37 0.18 0.29 5.00
8 INT286703 Mapk1 Positive_regulation of Phosphorylation of Hist1h3f 1 0.22 0.18 0.29 5.00
9 INT286706 Mapk1 Positive_regulation of Phosphorylation of Rps6ka5 1 0.37 0.18 0.29 5.00
10 INT286699 Positive_regulation of Mapk1 Positive_regulation of Phosphorylation of Creb1 1 0.22 0.18 0.28 5.00
11 INT286704 Mapk1 Positive_regulation of Phosphorylation of Creb1 1 0.32 0.18 0.28 5.00
12 INT286709 Mapk1 Positive_regulation of Rps6ka5 Positive_regulation of Rps6ka5 1 0.36 0.18 0.28 5.00
13 INT286701 Rps6ka5 Positive_regulation of Phosphorylation of Creb1 1 0.20 0.18 0.28 5.00
14 INT286707 Mapk1 Positive_regulation of Positive_regulation of Rps6ka5 1 0.37 0.18 0.28 5.00
15 INT264569 Binding of STS and ATF7IP 1 0.03 0.15 0.25 5.00
16 INT330986 CYP2C9 Positive_regulation of Gene_expression of CYP3A4 1 0.39 0 0.18 5.00
17 INT330985 CYP2C9 Positive_regulation of Gene_expression of CYP2C19 1 0.34 0 0.18 5.00
18 INT261518 Binding of DLG4 and HTR4 1 0.01 0 0.16 5.00
19 INT261521 Binding of ADCY1 and GLUL 1 0.01 0.09 0.15 5.00
20 INT261520 Binding of DLG4 and HTR2A 1 0.06 0 0.14 5.00
21 INT261519 Binding of HTR4 and USH1C 1 0.00 0 0.13 5.00
22 INT273063 Negative_regulation of Fas Negative_regulation of Positive_regulation of Bcl2 1 0.01 0.72 0.11 5.00
23 INT261556 Binding of USH1C and Olr1746 1 0.01 0 0.06 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Serotonin Syndrome. They are ordered first by their pain relevance and then by number of times they were reported in Serotonin Syndrome. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT59969 Positive_regulation of Htr1a 12 0.67 5.07 5.73 99.80
2 INT3812 Negative_regulation of Avpr1a 8 0.59 1.42 2.8 99.12
3 INT14124 Negative_regulation of Adra1a 34 0.59 7.48 10.85 99.12
4 INT20071 Positive_regulation of HTR2A 33 0.67 10.89 14 98.96
5 INT31116 Gene_expression of Casp3 192 0.78 78.21 57.43 96.28
6 INT78697 Negative_regulation of Gene_expression of Casp3 33 0.57 11.22 16.16 96.28
7 INT18121 Binding of Maoa 20 0.48 2.4 9.3 95.36
8 INT84059 Negative_regulation of Negative_regulation of Avpr1a 1 0.41 0.64 0.46 92.60
9 INT88571 Positive_regulation of Tcas1 4 0.34 2.08 4.42 88.72
10 INT232667 Binding of Pd 17 0.16 20.76 3.58 88.72
11 INT50405 Negative_regulation of CYP3A4 238 0.59 53.65 51.51 88.48
12 INT35744 Binding of MAOB 13 0.46 7.52 4.26 87.32
13 INT15913 Negative_regulation of CYP2D6 174 0.59 22.45 70.91 85.40
14 INT2040 Positive_regulation of CYP2B6 95 0.69 34.3 25.6 84.96
15 INT56337 Regulation of Cyp1a2 8 0.27 1.09 2.33 83.24
16 INT40857 Positive_regulation of MAOA 6 0.49 2.51 1.71 82.72
17 INT60779 Negative_regulation of CYP3A 63 0.59 8.38 21.27 82.48
18 INT235710 Binding of SSR1 2 0.36 0.86 1.75 82.24
19 INT129505 Regulation of Slc17a7 5 0.37 1.09 2.11 81.88
20 INT128273 Regulation of Gene_expression of Slc17a7 3 0.62 0.82 1.72 81.88
21 INT261850 Regulation of Positive_regulation of Slc17a7 1 0.10 0.49 0.58 81.88
22 INT67855 Negative_regulation of PPIG 64 0.57 17.83 13.54 81.24
23 INT96533 Gene_expression of Slc1a3 72 0.78 26.85 55.31 81.16
24 INT107930 Gene_expression of Slc17a7 39 0.78 6.53 18.86 81.16
25 INT2435 Negative_regulation of Cyp1a1 15 0.58 3.32 5.16 79.44
26 INT128269 Positive_regulation of Slc17a7 3 0.50 1.06 1.82 78.84
27 INT39914 Negative_regulation of Cyp1a2 44 0.58 10.04 22 77.20
28 INT158 Localization of Prl 2431 0.81 378.96 952.2 76.88
29 INT159 Negative_regulation of Localization of Prl 416 0.59 55.34 171.8 76.88
30 INT330997 Regulation of Positive_regulation of CYP2C19 1 0.35 0.3 0.47 75.68
31 INT331000 Regulation of Positive_regulation of CYP2D6 1 0.43 0.3 0.47 75.68
32 INT175262 Binding of SH2B2 18 0.36 22.85 3.18 75.52
33 INT50403 Negative_regulation of CYP2C19 55 0.59 8.97 17.79 73.60
34 INT62653 Positive_regulation of CYP2C19 8 0.54 1.23 2.41 73.60
35 INT10798 Positive_regulation of CYP2D6 24 0.56 5.82 11.31 72.72
36 INT58841 Gene_expression of HTR2A 33 0.75 9.01 9.07 71.52
37 INT62141 Positive_regulation of Gene_expression of HTR2A 8 0.67 2.47 2.42 71.52
38 INT1281 Negative_regulation of Maoa 203 0.59 22.47 91.66 71.12
39 INT71465 Gene_expression of HIST1H1B 9 0.58 4.69 0.36 69.60
40 INT157 Positive_regulation of Localization of Prl 790 0.70 104.54 374.78 68.96
41 INT546 Binding of ALB 311 0.48 85.98 60.14 67.44
42 INT2416 Negative_regulation of MAOA 92 0.59 42.24 36.5 64.72
43 INT4148 Gene_expression of HRH1 11 0.77 2.71 4.22 55.60
44 INT76336 Negative_regulation of PDE5A 192 0.59 112.02 20.09 52.72
45 INT224353 Localization of NMS 1 0.30 1.83 0.2 50.80
46 INT6177 Binding of Htr1a 65 0.47 17.65 30.59 48.64
47 INT12334 Positive_regulation of CYP3A 34 0.70 6.77 7.85 48.32
48 INT5704 Binding of Slc3a1 78 0.43 8.52 51.78 47.92
49 INT207780 Positive_regulation of NMS 2 0.28 3.2 0.61 45.80
50 INT92434 Phosphorylation of Mapk1 287 0.82 91.65 83.46 39.60
51 INT65600 Positive_regulation of Casp3 376 0.70 198.44 128.03 36.80
52 INT158593 Negative_regulation of Negative_regulation of CYP3A4 5 0.43 1.16 4.01 33.68
53 INT110551 Negative_regulation of Negative_regulation of CYP2D6 3 0.40 0.25 1.38 33.68
54 INT202715 Binding of NMS 3 0.27 6.92 0.65 31.28
55 INT49783 Negative_regulation of Cyp1a1 3 0.37 0.63 1.3 28.00
56 INT202577 Localization of DIO2 9 0.56 1.3 2.97 27.36
57 INT216731 Localization of HIST1H1B 2 0.19 1 0.59 27.04
58 INT635 Negative_regulation of MAOB 51 0.59 24.5 12.66 26.72
59 INT477 Localization of Avp 813 0.81 131.58 300.4 25.00
60 INT161 Regulation of Localization of Prl 615 0.62 65.37 298.66 25.00
61 INT4358 Positive_regulation of Localization of Avp 195 0.70 30.79 77.58 25.00
62 INT1319 Gene_expression of Oprl1 65 0.78 9.34 42.41 25.00
63 INT60764 Positive_regulation of PPIG 39 0.67 17.08 13.48 25.00
64 INT91709 Positive_regulation of PGP 4 0.69 1.09 0.77 25.00
65 INT25152 Gene_expression of SAA1 37 0.75 53.56 8.07 24.56
66 INT32515 Negative_regulation of B4GALNT1 82 0.43 28.1 17.46 20.04
67 INT9027 Positive_regulation of Ddc 24 0.66 6.04 10.19 16.44
68 INT2442 Localization of Mb 38 0.80 24.74 6.33 14.48
69 INT19181 Gene_expression of Bche 35 0.68 16.93 1.52 10.80
70 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 10.32
71 INT240680 Negative_regulation of Binding of HIST1H1B 2 0.10 0.55 0.41 9.84
72 INT31450 Binding of HIST1H1B 20 0.37 10.21 2.84 8.76
73 INT102187 Gene_expression of SH2B2 23 0.59 26.54 4.39 8.12
74 INT796 Gene_expression of Penk 1902 0.78 275.47 1057.59 5.00
75 INT7114 Positive_regulation of Ltp 1192 0.62 290.76 755.77 5.00
76 INT16260 Gene_expression of Bdnf 671 0.78 283.44 339.1 5.00
77 INT34869 Negative_regulation of PTGS2 778 0.59 366.76 319.85 5.00
78 INT9158 Gene_expression of Tnf 722 0.78 522.01 277.68 5.00
79 INT9987 Gene_expression of Abat 296 0.78 95.46 226.34 5.00
80 INT626 Localization of CALCA 289 0.81 125.39 221.15 5.00
81 INT95787 Positive_regulation of Mapk1 568 0.70 226.51 220.94 5.00
82 INT22548 Positive_regulation of Casp3 483 0.70 258.78 213.07 5.00
83 INT16259 Positive_regulation of Bdnf 336 0.70 183.48 209.82 5.00
84 INT2391 Negative_regulation of PTGS1 501 0.59 207.62 205.6 5.00
85 INT798 Positive_regulation of Gene_expression of Penk 394 0.70 78.53 203.07 5.00
86 INT7506 Negative_regulation of Ltp 267 0.46 91.01 176.8 5.00
87 INT49134 Gene_expression of Grin1 270 0.78 84.78 148.61 5.00
88 INT7628 Gene_expression of Ltp 273 0.77 70.21 147.87 5.00
89 INT2451 Positive_regulation of Avp 355 0.70 102.66 147.69 5.00
90 INT9852 Positive_regulation of Gpt 563 0.70 364.64 146.82 5.00
91 INT1273 Gene_expression of Avp 356 0.78 90.56 138.7 5.00
92 INT85640 Gene_expression of Tg(CAG-EGFP)D4Nagy 1138 0.72 311.58 119.18 5.00
93 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 5.00
94 INT7341 Positive_regulation of Grin1 169 0.70 65.86 118.38 5.00
95 INT16253 Positive_regulation of Gene_expression of Bdnf 196 0.70 92.67 113.01 5.00
96 INT7627 Negative_regulation of Positive_regulation of Ltp 162 0.50 41.2 106.27 5.00
97 INT74058 Gene_expression of Nos1 260 0.78 80.04 95.71 5.00
98 INT214 Localization of AVP 370 0.81 208.51 91.09 5.00
99 INT75999 Gene_expression of BDNF 344 0.78 114.19 83.12 5.00
100 INT12476 Negative_regulation of TRPV1 124 0.59 47.95 77.98 5.00
101 INT13036 Positive_regulation of Positive_regulation of Ltp 105 0.51 23.71 77.66 5.00
102 INT1724 Negative_regulation of ACE 437 0.59 315.64 74.48 5.00
103 INT79506 Gene_expression of Grin2b 122 0.78 43.71 73.42 5.00
104 INT1080 Negative_regulation of Ache 343 0.59 108.51 72.4 5.00
105 INT57380 Phosphorylation of Creb1 213 0.82 66.8 71.26 5.00
106 INT14049 Positive_regulation of GRIN1 102 0.70 48.31 71.06 5.00
107 INT13276 Regulation of Ltp 107 0.53 30.78 69.13 5.00
108 INT6176 Positive_regulation of Htr1a 117 0.67 28.23 66.17 5.00
109 INT1599 Positive_regulation of ADCY1 146 0.67 30.05 64.9 5.00
110 INT47690 Regulation of Bdnf 118 0.62 53.02 64.5 5.00
111 INT12175 Positive_regulation of PDYN 86 0.69 18.27 62.04 5.00
112 INT1169 Negative_regulation of Bche 322 0.59 149.22 61.27 5.00
113 INT3920 Localization of Ldha 241 0.81 83.08 58.72 5.00
114 INT119528 Positive_regulation of Camk2a 135 0.70 26.13 54.7 5.00
115 INT4957 Negative_regulation of Grin1 87 0.59 24.51 53.21 5.00
116 INT19775 Localization of Il1 183 0.78 145.5 50.91 5.00
117 INT4985 Positive_regulation of Tac1 81 0.69 35.79 50.67 5.00
118 INT51627 Gene_expression of Grin2a 82 0.76 25.09 47.6 5.00
119 INT374 Positive_regulation of Ldha 212 0.70 107.08 47.43 5.00
120 INT8713 Regulation of Tac1 56 0.60 25.29 45.94 5.00
121 INT9039 Negative_regulation of Htr1a 69 0.57 9.56 41.84 5.00
122 INT16261 Transcription of Bdnf 101 0.72 49.41 40.64 5.00
123 INT122953 Gene_expression of COMT 65 0.77 25.84 40.49 5.00
124 INT114751 Gene_expression of Mapk1 137 0.76 60.14 39.98 5.00
125 INT16455 Gene_expression of Drd2 116 0.78 22.71 38.47 5.00
126 INT56870 Gene_expression of CYP2D6 87 0.78 8.83 37.53 5.00
127 INT82054 Positive_regulation of Grin2b 56 0.70 17.45 37.14 5.00
128 INT10796 Gene_expression of CYP2B6 131 0.77 30.14 35.27 5.00
129 INT3679 Gene_expression of AVP 171 0.78 72.9 35.23 5.00
130 INT4403 Binding of CYP2B6 113 0.48 21.17 33.83 5.00
131 INT666 Gene_expression of Jun 124 0.78 54.61 33.67 5.00
132 INT117112 Negative_regulation of Mapk1 87 0.56 40.34 31.18 5.00
133 INT10797 Binding of CYP2D6 86 0.48 15.09 31.16 5.00
134 INT65597 Negative_regulation of Casp3 69 0.59 39.19 29.32 5.00
135 INT67912 Gene_expression of GRIN1 75 0.77 28.99 29.28 5.00
136 INT22211 Positive_regulation of CYP3A4 110 0.70 22 28.27 5.00
137 INT91775 Gene_expression of Slc6a4 102 0.78 26.45 28.23 5.00
138 INT12129 Gene_expression of CYP3A4 107 0.78 23.11 27.6 5.00
139 INT73314 Gene_expression of Arc 133 0.78 67.78 27.44 5.00
140 INT80470 Negative_regulation of Gene_expression of Grin1 33 0.59 10.22 27.15 5.00
141 INT6594 Gene_expression of HTR1D 60 0.75 10.15 27.13 5.00
142 INT32826 Positive_regulation of Gene_expression of Ltp 52 0.45 10.34 26.8 5.00
143 INT63444 Regulation of Gene_expression of Abat 26 0.51 14.65 26.29 5.00
144 INT276 Regulation of Ache 83 0.62 16.75 25.99 5.00
145 INT95788 Positive_regulation of Positive_regulation of Mapk1 83 0.69 24.75 25.84 5.00
146 INT9781 Binding of INSRR 64 0.31 19.1 25.2 5.00
147 INT57192 Binding of Ltp 43 0.41 17.48 24.96 5.00
148 INT100423 Gene_expression of Bax 141 0.75 98.43 24.48 5.00
149 INT13838 Positive_regulation of Drd1a 48 0.70 9.83 23.42 5.00
150 INT47741 Negative_regulation of Flvcr2 43 0.51 5.72 23.37 5.00
151 INT9282 Gene_expression of HTR1B 48 0.75 12.15 22.94 5.00
152 INT110638 Negative_regulation of COMT 43 0.59 21.03 21.05 5.00
153 INT93485 Negative_regulation of Slc1a2 27 0.59 10.65 20.9 5.00
154 INT105021 Binding of GOPC 187 0.40 60.39 20.38 5.00
155 INT135629 Binding of COMT 33 0.48 16.68 19.37 5.00
156 INT90612 Positive_regulation of Grin2a 33 0.65 15.11 18.84 5.00
157 INT4420 Positive_regulation of GOT1 103 0.64 88.4 18.38 5.00
158 INT50579 Binding of CYP3A4 84 0.48 17.52 17.45 5.00
159 INT86673 Positive_regulation of Bcl2 77 0.70 57.74 17.37 5.00
160 INT50404 Negative_regulation of CYP1A2 49 0.59 8.61 17.35 5.00
161 INT26972 Negative_regulation of Tenc1 57 0.57 56.71 16.87 5.00
162 INT77620 Gene_expression of Fas 146 0.78 72.4 16.61 5.00
163 INT59365 Gene_expression of HTR1A 41 0.75 16.31 16.57 5.00
164 INT1020 Negative_regulation of BCHE 109 0.59 44.86 16.4 5.00
165 INT4616 Regulation of Maoa 40 0.62 6.09 15.94 5.00
166 INT47742 Binding of Flvcr2 26 0.42 3.28 15.87 5.00
167 INT4340 Positive_regulation of Localization of Ldha 46 0.70 14.52 15.66 5.00
168 INT9783 Gene_expression of INSRR 81 0.50 32.99 15.52 5.00
169 INT170855 Negative_regulation of GOPC 188 0.38 70.92 15.41 5.00
170 INT11945 Regulation of Chat 38 0.62 7.75 14.97 5.00
171 INT74098 Negative_regulation of Gene_expression of Nos1 36 0.59 16.25 14.82 5.00
172 INT11340 Positive_regulation of SLC17A5 120 0.67 113.52 14.5 5.00
173 INT42979 Positive_regulation of INSRR 47 0.32 12.24 14.38 5.00
174 INT4736 Gene_expression of Chat 67 0.77 17.15 14.24 5.00
175 INT7342 Positive_regulation of Positive_regulation of Grin1 18 0.50 9.22 13.76 5.00
176 INT18012 Gene_expression of EPO 169 0.78 108.36 13.75 5.00
177 INT100655 Regulation of BDNF 51 0.60 21.49 13.14 5.00
178 INT9231 Binding of Htr3a 27 0.47 7.29 13.04 5.00
179 INT30961 Binding of HTR2A 33 0.47 11.44 12.86 5.00
180 INT35467 Gene_expression of DIO2 37 0.65 9.56 12.61 5.00
181 INT12191 Negative_regulation of Localization of Ldha 35 0.59 13.71 12.35 5.00
182 INT50580 Binding of PPIG 39 0.36 11.17 12.34 5.00
183 INT541 Positive_regulation of MBP 31 0.67 28.56 12.24 5.00
184 INT15756 Positive_regulation of Gene_expression of Jun 29 0.69 16.58 12.06 5.00
185 INT2415 Binding of MAOA 26 0.47 13.26 11.86 5.00
186 INT56048 Positive_regulation of Transcription of Bdnf 24 0.70 8.33 11.83 5.00
187 INT170601 Positive_regulation of Gene_expression of GOPC 122 0.43 42.79 11.68 5.00
188 INT1190 Positive_regulation of F2 53 0.70 46.41 11.64 5.00
189 INT54466 Negative_regulation of Gene_expression of Ltp 19 0.38 5.44 10.91 5.00
190 INT22210 Gene_expression of CYP1A2 45 0.78 4.95 10.66 5.00
191 INT55418 Regulation of CYP2D6 29 0.61 1.83 10.21 5.00
192 INT31780 Binding of DIO2 17 0.36 10.07 10 5.00
193 INT7044 Positive_regulation of Positive_regulation of Htr1a 17 0.67 3.5 10 5.00
194 INT17741 Gene_expression of MBP 67 0.78 23.67 9.65 5.00
195 INT72789 Gene_expression of Cpa1 29 0.50 12.36 9.47 5.00
196 INT1218 Negative_regulation of Maob 24 0.59 9.76 9.39 5.00
197 INT95342 Gene_expression of GRIN2B 21 0.75 4.99 9.32 5.00
198 INT7090 Gene_expression of pcp 50 0.66 13.54 8.96 5.00
199 INT108931 Negative_regulation of BDNF 38 0.59 19.61 8.84 5.00
200 INT52243 Phosphorylation of Ltp 13 0.54 2.84 8.7 5.00
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