D:Sezary Syndrome

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Disease Term
Synonyms Erythroderma Sezary, Sezary Erythroderma, SYNDROME SEZARY
Documents 9
Hot Single Events 14
Hot Interactions 2

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Sezary Syndrome. They are ordered first by their relevance to Sezary Syndrome and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT350906 Twist1 Positive_regulation of Gene_expression of Cd4 1 0.10 1.49 0 97.20
2 INT350907 Twist1 Positive_regulation of Gene_expression of Cd7 1 0.05 1.49 0 97.20
3 INT277692 Binding of Atp9a and Tnfrsf10b 1 0.00 1.47 0.1 5.00
4 INT350909 Binding of Pcsk4 and Twist1 1 0.02 1.91 0.08 5.00
5 INT350908 Binding of Bcl2 and Twist1 1 0.04 1.9 0.08 5.00
6 INT350905 Binding of Bcl2 and Pcsk4 1 0.03 0.96 0.04 5.00
7 INT277693 Stat6 Positive_regulation of Positive_regulation of Casp3 1 0.01 1.01 0 5.00
8 INT277691 Cdkn1a Negative_regulation of Positive_regulation of Casp3 1 0.00 1.01 0 5.00
9 INT297614 ZNF275 Positive_regulation of Gene_expression of TSC1 1 0.00 1.56 0 5.00
10 INT297613 Negative_regulation of ZNF275 Positive_regulation of Gene_expression of TSC1 1 0.00 1.66 0 5.00
11 INT297615 Binding of TSC1 and HDAC9 1 0.01 0.4 0 5.00
12 INT277694 Cdkn1a Positive_regulation of Positive_regulation of Casp3 1 0.00 1.01 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Sezary Syndrome. They are ordered first by their pain relevance and then by number of times they were reported in Sezary Syndrome. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT77307 Gene_expression of Bcl2 399 0.77 319.77 38 99.56
2 INT81640 Positive_regulation of Gene_expression of Bcl2 106 0.69 84.58 11.63 99.56
3 INT59962 Gene_expression of Pcsk4 2 0.49 3 0 97.92
4 INT49214 Gene_expression of Cd4 269 0.78 154.22 34.05 96.84
5 INT135527 Negative_regulation of Gene_expression of Cd4 17 0.43 6.72 1.09 96.84
6 INT350901 Positive_regulation of Pcsk4 1 0.08 1.59 0 96.72
7 INT350902 Negative_regulation of Cd7 1 0.15 1.87 0 96.40
8 INT350903 Gene_expression of Cd7 1 0.23 1.48 0 96.12
9 INT174515 Negative_regulation of CD7 2 0.14 2.15 0.39 92.64
10 INT43820 Positive_regulation of Twist1 75 0.59 42.15 8.47 92.00
11 INT22900 Positive_regulation of Cd4 126 0.67 82.77 16.43 91.64
12 INT350899 Positive_regulation of Cd7 1 0.14 0.78 0 91.24
13 INT79395 Gene_expression of Twist1 193 0.77 100.06 26.34 91.04
14 INT80222 Negative_regulation of Bcl2 82 0.58 69.16 13.18 89.72
15 INT50051 Regulation of Pcsk4 2 0.24 1.07 0.13 79.72
16 INT64234 Regulation of Bcl2 41 0.54 31.88 3.16 75.28
17 INT83236 Localization of PGR 14 0.73 8.26 2.23 75.08
18 INT61619 Gene_expression of IL12A 194 0.77 146.07 41.97 71.84
19 INT83119 Negative_regulation of Gene_expression of IL12A 24 0.42 17.52 5.69 71.84
20 INT16322 Gene_expression of Il2rb 19 0.51 15.88 12.18 71.48
21 INT275245 Positive_regulation of HIST2H2BE 2 0.15 1.94 0 71.44
22 INT297621 Positive_regulation of RLN3 1 0.05 2.79 0 71.44
23 INT18909 Positive_regulation of Cd8a 92 0.60 56.55 7.35 62.08
24 INT279323 Binding of Il2rb 1 0.09 1.86 0 61.80
25 INT133647 Negative_regulation of HDAC9 149 0.57 106.84 17.9 47.88
26 INT59964 Localization of Pcsk4 3 0.59 2.25 0.23 36.08
27 INT214706 Gene_expression of Bok 3 0.09 7.22 0.11 30.44
28 INT10873 Localization of Twist1 21 0.74 10.43 1.37 29.40
29 INT350904 Localization of TSPYL2 1 0.03 1.04 0.04 28.48
30 INT90792 Localization of Il10 144 0.80 87.88 30.03 27.72
31 INT20379 Localization of Il4 85 0.73 51.22 20.55 27.72
32 INT19509 Localization of Ifng 55 0.78 28.25 18.67 27.72
33 INT20381 Localization of Il2 71 0.77 34.23 13.03 27.72
34 INT35086 Positive_regulation of Gene_expression of Ifng 40 0.69 22.55 18.35 26.16
35 INT7532 Negative_regulation of Gene_expression of Ifng 33 0.59 18.56 13.14 25.84
36 INT21532 Negative_regulation of Gene_expression of Il2 47 0.59 20.43 16.96 24.52
37 INT141275 Negative_regulation of Gene_expression of Hand1 18 0.34 15.83 5.05 24.52
38 INT7534 Gene_expression of Ifng 193 0.78 111.02 68.6 24.12
39 INT11807 Gene_expression of Il2 266 0.78 112 64.97 24.12
40 INT20375 Gene_expression of Hand1 213 0.60 148.51 54.53 24.12
41 INT3988 Positive_regulation of Gene_expression of IGHE 98 0.68 91.46 9.61 15.76
42 INT3375 Gene_expression of IGHE 535 0.77 387.47 65.46 15.36
43 INT174753 Gene_expression of Apoa2 15 0.75 13.82 0.41 14.16
44 INT65600 Positive_regulation of Casp3 376 0.70 198.44 128.03 5.00
45 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53 5.00
46 INT28215 Gene_expression of CDKN1A 196 0.76 113.9 18.3 5.00
47 INT10187 Gene_expression of Il2ra 91 0.78 52.67 16.66 5.00
48 INT3400 Positive_regulation of pr 57 0.68 36.9 16.24 5.00
49 INT59929 Negative_regulation of CYP2C9 60 0.59 16.33 15.39 5.00
50 INT81627 Gene_expression of Fas 120 0.78 115.51 15.36 5.00
51 INT75502 Positive_regulation of CDKN1A 123 0.68 70.75 14.74 5.00
52 INT62269 Gene_expression of Cdkn1a 60 0.73 35.78 9.84 5.00
53 INT57162 Positive_regulation of Gene_expression of CDKN1A 64 0.68 35.3 9.69 5.00
54 INT114874 Gene_expression of Stat3 78 0.76 53.99 9.49 5.00
55 INT53487 Gene_expression of TSC1 81 0.58 77.71 7.94 5.00
56 INT102572 Gene_expression of Ccnd1 79 0.69 56.37 7.34 5.00
57 INT192225 Gene_expression of HDAC9 35 0.58 32.82 6.36 5.00
58 INT17892 Gene_expression of Myc 57 0.75 36.37 5.82 5.00
59 INT62270 Positive_regulation of Gene_expression of Cdkn1a 30 0.47 18.73 5.69 5.00
60 INT125066 Negative_regulation of HDAC4 56 0.49 41.55 5.42 5.00
61 INT55114 Gene_expression of CRS 42 0.58 26.86 4.69 5.00
62 INT56562 Positive_regulation of Gene_expression of Il2rb 6 0.45 3.17 4.34 5.00
63 INT12923 Negative_regulation of Atp9a 17 0.35 7.87 3.52 5.00
64 INT89966 Negative_regulation of Fas 26 0.58 24.83 3.5 5.00
65 INT62268 Positive_regulation of Cdkn1a 33 0.67 14.12 3.26 5.00
66 INT61087 Positive_regulation of Gene_expression of Il2ra 12 0.35 9.1 3.25 5.00
67 INT76024 Negative_regulation of Cyp3a11 7 0.53 2.96 3.16 5.00
68 INT31450 Binding of HIST1H1B 20 0.37 10.21 2.84 5.00
69 INT41721 Negative_regulation of MTOR 40 0.58 32.49 2.83 5.00
70 INT36100 Positive_regulation of Il2rb 7 0.49 4.18 2.32 5.00
71 INT133648 Regulation of HDAC9 14 0.60 10.01 2.18 5.00
72 INT109971 Positive_regulation of Tpt1 23 0.69 13.69 2.14 5.00
73 INT191154 Binding of HDAC9 20 0.36 14.12 1.83 5.00
74 INT158374 Negative_regulation of Aadac 13 0.07 7.19 1.76 5.00
75 INT108327 Negative_regulation of Gene_expression of Ccnd1 18 0.38 14.36 1.31 5.00
76 INT133898 Binding of HSP90AA1 17 0.30 8.83 1.12 5.00
77 INT172855 Binding of Bcl2 37 0.32 23.41 1.09 5.00
78 INT200738 Gene_expression of HIST2H4A 7 0.18 4.65 0.91 5.00
79 INT124850 Gene_expression of Tpt1 42 0.77 14.51 0.79 5.00
80 INT169911 Phosphorylation of Rb1 35 0.73 18.58 0.79 5.00
81 INT176606 Gene_expression of Stat6 9 0.65 6.87 0.77 5.00
82 INT129115 Negative_regulation of Cdkn2a 16 0.50 17.03 0.76 5.00
83 INT144390 Positive_regulation of Negative_regulation of CYP2C9 4 0.49 2.03 0.72 5.00
84 INT154491 Phosphorylation of pr 2 0.79 1.94 0.7 5.00
85 INT228246 Negative_regulation of Gene_expression of Stat3 10 0.58 8.11 0.64 5.00
86 INT144701 Gene_expression of Cdkn2a 15 0.75 8.42 0.53 5.00
87 INT97606 Negative_regulation of Cdkn1a 7 0.43 4.24 0.42 5.00
88 INT243603 Localization of Stat6 6 0.68 2.96 0.4 5.00
89 INT64977 Gene_expression of TFF3 9 0.75 3.54 0.39 5.00
90 INT297626 Gene_expression of RLN3 3 0.11 5.07 0.3 5.00
91 INT256540 Regulation of Gene_expression of TSC1 4 0.07 4.74 0.3 5.00
92 INT228477 Positive_regulation of Gene_expression of Cdkn2a 2 0.11 1.3 0.29 5.00
93 INT265661 Positive_regulation of Gene_expression of HIST2H4A 2 0.09 2.69 0.28 5.00
94 INT102071 Negative_regulation of Gene_expression of Myc 8 0.57 3.5 0.22 5.00
95 INT170847 Gene_expression of Ccne2 6 0.58 2.98 0.21 5.00
96 INT120615 Negative_regulation of TFF3 2 0.42 1.5 0.13 5.00
97 INT261118 Binding of Tnfrsf10b 3 0.07 4.03 0.1 5.00
98 INT124852 Positive_regulation of Gene_expression of Tpt1 10 0.50 3.95 0.1 5.00
99 INT350932 Positive_regulation of Gene_expression of Bok 1 0.03 2.46 0.09 5.00
100 INT154423 Regulation of CDAN1 2 0.60 1.55 0.09 5.00
101 INT350931 Gene_expression of Rad23b 1 0.27 1.89 0.08 5.00
102 INT297627 Positive_regulation of Gene_expression of RLN3 3 0.08 3.06 0.08 5.00
103 INT350900 Protein_catabolism of Twist1 1 0.22 0.78 0.05 5.00
104 INT284979 Binding of HIST2H4A 2 0.05 2 0.04 5.00
105 INT277669 Positive_regulation of Negative_regulation of Cyp3a11 1 0.09 1.46 0.03 5.00
106 INT277672 Localization of Cdkn1a 1 0.07 0.95 0 5.00
107 INT274683 Localization of HIST2H4A 5 0.12 1.54 0 5.00
108 INT297623 Localization of HDAC11 1 0.29 0.26 0 5.00
109 INT277667 Positive_regulation of Gene_expression of Ccne2 1 0.01 0.52 0 5.00
110 INT297619 Binding of RLN3 1 0.02 1.4 0 5.00
111 INT297620 Negative_regulation of Positive_regulation of RLN3 1 0.03 1.04 0 5.00
112 INT277670 Negative_regulation of Gene_expression of Stat6 1 0.14 2.12 0 5.00
113 INT277668 Positive_regulation of Localization of Stat6 1 0.14 2 0 5.00
114 INT350933 Gene_expression of Hdac11 1 0.33 0.12 0 5.00
115 INT297625 Positive_regulation of Binding of RLN3 1 0.03 1.42 0 5.00
116 INT279322 Regulation of Gene_expression of Il2rb 1 0.14 0.3 0 5.00
117 INT297628 Negative_regulation of ZNF275 1 0.00 3.2 0 5.00
118 INT277673 Positive_regulation of Localization of Cdkn1a 1 0.05 1.01 0 5.00
119 INT297622 Positive_regulation of Binding of HIST2H4A 1 0.06 1.42 0 5.00
120 INT297624 Localization of RLN3 1 0.05 1 0 5.00
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